First Published in 2004. Routledge is an imprint of Taylor & Francis, an informa company.

Plasmodium falciparum is the most deadly human malarial parasite, responsible for an estimated 207 million cases of disease and 627,000 deaths in 2012. Recent studies reveal that the parasite actively regulates a large fraction of its genes throughout its replicative cycle inside human red blood cells and that epigenetics plays an important role in this precise gene regulation. Here, we discuss recent advances in our understanding of three aspects of epigenetic regulation in P. falciparum: changes in histone modifications, nucleosome occupancy (...) and the three‐dimensional genome structure. We compare these three aspects of the P. falciparum epigenome to those of other eukaryotes, and show that large‐scale compartmentalization is particularly important in determining histone decomposition and gene regulation in P. falciparum. We conclude by presenting a gene regulation model for P. falciparum that combines the described epigenetic factors, and by discussing the implications of this model for the future of malaria research. (shrink)

Although the commentary on Aristotle’s problematic discussion of slavery is vast, his discussion of nobility receives little attention. The fragments of his dialogue On Noble Birth constitute his most extensive examination of nobility, and while their similarity to the παμβασιλεύς of the Politics has recently been recognized, their relevance to natural slavery has hitherto gone unnoticed. Yet by declaring that true nobles – particularly the god-like ἀρχηγός – preternaturally possess superhuman characteristics, Aristotle precludes their easy inclusion in the kind (...) “human” in a manner inversely mirroring the preternatural subhumanity of natural slaves. Building on recent scholarship which argues that Aristotle’s “defense” of natural slaves is better understood as an indictment, On Noble Birth becomes most coherent if read as a hypothetical investigation into what would be required for “nobility” to name something true rather than equivocal, with the conclusion that “true nobility” is an empty set. (shrink)

The tradition of the political lie infamously commences with Platos Noble Lie in the Republic. It is woven with great care into his utopian state on the premise that Philosopher-Rulers are incorruptible wielders of political power.Most treatments of the Noble Lie understand this and then proceed to dismiss Plato on the basis of his unrealistic assumptions about human nature. But when consideration is extended to the Laws, one finds a far more nuanced and relevant Plato uncomfortable with the (...) > practice of political deception. This article elaborates on the Noble Lie and its assumptions, and then explains how the later Platos increased scepticism about human nature informed a different policy in his Laws. (shrink)

In American Poetic Materialism from Whitman to Stevens, Mark Noble examines writers who rethink the human in material terms. Do our experiences correlate to our material elements? Do visions of a common physical ground imply a common purpose? Noble proposes new readings of Walt Whitman, Ralph Waldo Emerson, William James, George Santayana and Wallace Stevens that explore a literary history wrestling with the consequences of its own materialism. At a moment when several new models of the relationship (...) between human experience and its physical ground circulate among critical theorists and philosophers of science, this book turns to poets who have long asked what our shared materiality can tell us about our prospects for new models of our material selves. (shrink)

Imprint covered by label which reads : Barnes & Noble Books, Totowa, N.J. Includes bibliographical references and index.

Philosophers are often praised for their insight even if they are found wanting in their powers of analysis. The noble edifices of thought raised by the famous have been reduced to more or less noble ruins, if we consider what disintegrating, analytical time and tide have done to the weaker members of the structures. Some of the palaces of thought even seem to stand without any foundations. Yet they stand. They are admired no longer for their utility or (...) for their massiveness, but for the beauty of their conception. Their conception is said to represent the insight of their authors. (shrink)

This book, first published 1931, examines the attitudes surrounding the natural sciences at the time of writing, and contends that an unreflective belief in the power of science, and especially in humanity's capacity to turn such knowledge to noble ends, could lead to catastrophic results for human civilisation. Commenting on the forced industrialisation in Russia, India and China that was proceeding with little regard for human life at the time, the unsustainable inequality generated by modern Western capitalism and many (...) other related issues, the author argues that it is necessary to devote the same energy to the resolution of social problems as to scientific research and development. His thesis, though expounded with reference to concrete situation different from our own, is nonetheless as relevant today as it was when first published. (shrink)

This chapter contains sections titled: Acknowledgments References.

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 27.2 (2003) 402-414 [Access article in PDF] Past's Weight, Future's Promise:Reading Electra William Junker I SOPHOCLES' Electrapresents as its main character a woman who is tortured by the remembrance of things past: Even my pitiful bed remembers, there in that dreadful house, my long night-watches grieving my unlucky father who found no foreign resting place in war but died when my mother and Aegisthus, her (...) lover, took an axe to his head as a woodman does a tree. (85-95) 1The story she tells is a familiar one. Her father, Agamemnon, having returned from the Trojan War, is murdered by Clytemnestra and her lover Aegisthus. Clytemnestra's motives are complex and unclear, for Agamemnon had previously sacrificed their daughter, Iphigenia, in order to ensure military success, and it is an open question as to what extent maternal vengeance as opposed to romantic intrigue motivated [End Page 402] her action. After the murder, Electra rescues her brother Orestes from probable death by sending him abroad (Aegisthus fearing revenge would have killed the child) while she grows and lives as an outcast in her own home, awaiting the day when the grown Orestes will return and bring their father's murderers to justice.The story, and its ensuing consequences, had already been handled masterfully in Aeschylus' Oresteia; but in Sophocles' play there is considerably more interest shown in Electra herself. 2 This focus results in a magnification of Electra's mourning for her father along with a sustained meditation upon how this mourning results in her inability to live, in any full sense, with the knowledge of his death. She cannot escape the memory of the injustice done him, and this memory fuels her hopes for Orestes' return even as it renders her, for all practical purposes, incapacitated.Her character thus described draws continual attention during the course of the play, and in their first appearance the Chorus admonishes her: "When you go on too far with grief, / you come to endless anguish, and destroy yourself. / There is no salvation from your troubles here, / so why should you persist in suffering" (136-39). Electra herself views her persistent suffering as necessary and noble, a show of allegiance to her murdered father and a refusal to compromise with his killers. The Chorus and Chrysothemis, however, argue that by so carrying on Electra is in reality causing more damage to herself than her situation warrants. Her ragged appearance, quite noticeable stench, and public outcries do nothing to help redress her father's honor; they rather highlight her mania and point toward insanity. At one point Chrysothemis implies as much. To Electra's accusation that her position of political compromise is dishonorable, she rebuts: "There's honor in not letting madness defeat you" (395)—suggesting both a different conception of honor and a veiled appraisal of her sister's mental health. In the service of life and sanity, the Chorus and Chrysothemis seem to say, leave off your suffering. In the service of honor and the dead, Electra rejoins, I cannot. The movement of the play in fact continually juxtaposes the position of Electra with that of her critics, and this juxtaposition is one that calls for interpretive elucidation. 3An especially fertile way of adjudicating these issues in Electra is afforded us by Nietzsche, and, specifically, by his On the Advantage and Disadvantage of History for Life. This is the case because, as I want to suggest, Nietzsche's essay provides a framework which reconstructs, and in a unique way, the central problem of Electra. That problem is [End Page 403] essentially one of reconciling the conflicting claims of familial honor and memory with the claims of life. Through Nietzsche's exposition of history and its relation to life, this problem is both illumined and given greater subtlety—illumined, in that the potential agôn between history and life, while present in Sophocles' Electra, is not just obvious; and made subtle, in that Nietzsche's proposed solution to this agôn allows for a reading of the... (shrink)

The tremendous influence Stoicism has exerted on ethical thought from early Christianity through Immanuel Kant and into the twentieth century is rarely understood and even more rarely appreciated. Throughout history, Stoic ethical doctrines have both provoked harsh criticisms and inspired enthusiastic defenders. The Stoics defined the goal in life as living in agreement with nature. Humans, unlike all other animals, are constituted by nature to develop reason as adults, which transforms their understanding of themselves and their own true good. The (...) Stoics held that virtue is the only real good and so is both necessary and, contrary to Aristotle, sufficient for happiness; it in no way depends on luck. The virtuous life is free of all passions, which are intrinsically disturbing and harmful to the soul, but includes appropriate emotive responses conditioned by rational understanding and the fulfillment of all one's personal, social, professional, and civic responsibilities. The Stoics believed that the person who has achieved perfect consistency in the operation of his rational faculties, the "wise man," is extremely rare, yet serves as a prescriptive ideal for all. The Stoics believed that progress toward this noble goal is both possible and vitally urgent. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 27.2 (2003) 402-414 [Access article in PDF] Past's Weight, Future's Promise:Reading Electra William Junker I SOPHOCLES' Electrapresents as its main character a woman who is tortured by the remembrance of things past: Even my pitiful bed remembers, there in that dreadful house, my long night-watches grieving my unlucky father who found no foreign resting place in war but died when my mother and Aegisthus, her (...) lover, took an axe to his head as a woodman does a tree. (85-95) 1The story she tells is a familiar one. Her father, Agamemnon, having returned from the Trojan War, is murdered by Clytemnestra and her lover Aegisthus. Clytemnestra's motives are complex and unclear, for Agamemnon had previously sacrificed their daughter, Iphigenia, in order to ensure military success, and it is an open question as to what extent maternal vengeance as opposed to romantic intrigue motivated [End Page 402] her action. After the murder, Electra rescues her brother Orestes from probable death by sending him abroad (Aegisthus fearing revenge would have killed the child) while she grows and lives as an outcast in her own home, awaiting the day when the grown Orestes will return and bring their father's murderers to justice.The story, and its ensuing consequences, had already been handled masterfully in Aeschylus' Oresteia; but in Sophocles' play there is considerably more interest shown in Electra herself. 2 This focus results in a magnification of Electra's mourning for her father along with a sustained meditation upon how this mourning results in her inability to live, in any full sense, with the knowledge of his death. She cannot escape the memory of the injustice done him, and this memory fuels her hopes for Orestes' return even as it renders her, for all practical purposes, incapacitated.Her character thus described draws continual attention during the course of the play, and in their first appearance the Chorus admonishes her: "When you go on too far with grief, / you come to endless anguish, and destroy yourself. / There is no salvation from your troubles here, / so why should you persist in suffering" (136-39). Electra herself views her persistent suffering as necessary and noble, a show of allegiance to her murdered father and a refusal to compromise with his killers. The Chorus and Chrysothemis, however, argue that by so carrying on Electra is in reality causing more damage to herself than her situation warrants. Her ragged appearance, quite noticeable stench, and public outcries do nothing to help redress her father's honor; they rather highlight her mania and point toward insanity. At one point Chrysothemis implies as much. To Electra's accusation that her position of political compromise is dishonorable, she rebuts: "There's honor in not letting madness defeat you" (395)—suggesting both a different conception of honor and a veiled appraisal of her sister's mental health. In the service of life and sanity, the Chorus and Chrysothemis seem to say, leave off your suffering. In the service of honor and the dead, Electra rejoins, I cannot. The movement of the play in fact continually juxtaposes the position of Electra with that of her critics, and this juxtaposition is one that calls for interpretive elucidation. 3An especially fertile way of adjudicating these issues in Electra is afforded us by Nietzsche, and, specifically, by his On the Advantage and Disadvantage of History for Life. This is the case because, as I want to suggest, Nietzsche's essay provides a framework which reconstructs, and in a unique way, the central problem of Electra. That problem is [End Page 403] essentially one of reconciling the conflicting claims of familial honor and memory with the claims of life. Through Nietzsche's exposition of history and its relation to life, this problem is both illumined and given greater subtlety—illumined, in that the potential agôn between history and life, while present in Sophocles' Electra, is not just obvious; and made subtle, in that Nietzsche's proposed solution to this agôn allows for a reading of the... (shrink)

When Festus said to Paul: ‘Much learning doth make thee mad’, Paul's answer was the instinctive defence of a scholar under attack: ‘I am not mad, most noble Festus, but speak forth the words of truth and soberness’. Whether poets were mad or sober has been a question for critics ever since Gorgias pointed out the incompatibility; it is less frequently debated why scholars unlike poets should need to affirm their sobriety. I should like to concentrate on one aspect (...) of ancient criticism, that of problem-solving, in order, as I hope, to put into a different perspective the whole business of what Alexandrians did with texts. Inevitably perhaps it will be argued that I am neglecting the vast philological and lexical labours of the Alexandrians and failing to appreciate their subtlety in textual criticism. I hope that my criticisms will not be construed in this way; yet I believe that the Alexandrians have been idealized and their critical attitudes over-simplified. By taking a problem from antiquity and setting it in its context, I will be trying to give what I consider to be a more correct perspective to the labours of our ancient predecessors. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Hannah Arendt and Theology by John KiessGregory WilliamsHannah Arendt and Theology John Kiess NEW YORK: BLOOMSBURY T&T CLARK, 2016. XI 1 249 PP. $21.99Of the great secular Jewish thinkers of the mid-twentieth century, none has occasioned quite so much recent attention among Christian theologians as Hannah Arendt. Arendt's popularity is due to a number of factors, not least of which is the ongoing revival of Augustine's thought in (...) political theology, and it is unlikely to subside any time soon. This is why John Kiess's most recent volume, Hannah Arendt and Theology, is of importance to the field of Christian ethics.After providing an intellectual biography of Arendt, the bulk of Kiess's text is devoted to the key loci that theological authors have highlighted in her work, [End Page 210] specifically her concepts of evil, citizenship, action, and thinking. In writing about each of these, Kiess articulates the ways in which theologians have underestimated Arendt. For example, in defending Arendt vis-à-vis Eric Gregory, Kiess argues that "Arendt points to a kind of love that Augustine appears to have overlooked, one which, if falling short of the love of God and neighbor, reaches higher than the love of self to the good of what is common to all" (121).At the same time, Kiess also points out the places where Arendt underestimates Christian theology. Possibly his biggest critique is that, in arguing that the evils of totalitarianism not only transcend but completely "break" traditional definitions of evil, Arendt assumes tradition to be a static article passed on intact from one generation to the next. Against this view, Kiess holds up Alasdair MacIntyre's definition of a tradition as an ongoing argument and shows how Arendt's efforts actually demonstrate the way traditions operate dynamically in contexts of ongoing crisis.Both of these examples also point to broader metaethical questions. In particular, Kiess's statement that Augustine "overlooked" the existence of a nonsalvific love that still rises above the level of the lust for domination that constitutes the telos of the earthly city, or even the love of human glory that gives rise to its greatest virtues, seems to elide the fact that neither Augustine nor his contemporary interpreters have simply forgotten about such a possibility; rather, a chief insight of Augustinian political thought is to deny it. This is precisely why Augustine, as Kiess notes, "longed for a more transformative founding" than Arendt does in her stress on human natality (178). Kiess, it seems, wants to have it both ways on this point. Either the loves of the earthly city can amount to something more than an ethics domination or glory, in which case Augustine's doubts about the founding of political entities based on those loves is overly pessimistic, or the loves and the goods of the earthly and heavenly cities are incommensurable, in which case Arendt's amor mundi, however noble its outcomes, is not immune to the degradations of the earthly city as a whole and must be regarded as one more penultimate earthly virtue.This brings us back to the question of tradition. For all his emphasis on how Arendt exemplifies the dynamism and responsiveness of traditions, Kiess never actually specifies to which tradition Arendt belonged. To put it bluntly, he does not treat it as relevant that Arendt was not a Christian. While she is an extensive and extremely helpful commentator on the Christian theological tradition, she wrote as a critic and an outsider. We can expect certain basic differences between Arendt and her Christian interlocutors to remain irresolvable because that is the nature of interreligious difference. That does not mean, however, that dialogue is not fruitful, and it is because of this that Kiess's text is, and is likely to remain, extremely generative. [End Page 211]Gregory WilliamsDuke UniversityCopyright © 2017 Society of Christian Ethics... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 155 Humanae Vitae: A Generation Later. By JANET SMITH. Washington, D.C.: The Catholic University of America Press, 1991. Pp. xvi + 425. $42.95 hardcover; $17.95 paper. This is an ambitious and important study. I will first offer an overview of the volume to indicate its scope and note some of its major features. I will then respond briefly to some of the major criticisms Smith makes of (...) the argument against contraception advanced by Germain Grisez, Joseph Boyle, John Finnis, and myself. The work contains 8 chapters and 4 appendices. Chapters 3 and 4, as Smith says, "provide an analysis of Humanae Vitae itself and thus constitute the heart of the hook" (p. xi). Since this is so I will first summarize briefly Chapters 1, 2, 5, 6, 7, and 8 and then center atten· tion on the two central chapters and the four appendices. Chapters 1 and 2 provide the context for Humanae Vitae. The first chapter is devoted largely to an account of the so-called " Minority " and "Majority" documents of the Papal Commission for the Study of Problems of the Family, Population, and Birth Rate, while the second seeks to summarize Catholic teaching on Christian marriage prior to the encyclical. This summary draws principally from Pius XI's Casti Connubii and from nn. 47-52 of Vatican II's Gaudium et Spes. Smith takes up in some detail the issue of the" primacy" of procreation, concluding that Gaudium et Spes " seems to sidestep " this issue which, in her judgment, is irrelevant to the question of contraception. She thinks that this central document of Vatican II sent " mixed signals " on the question of contraception, although she believes that several passages " can very plausibly he read to support the position that contraception is portrayed as a violation not only of the procreative good of marriage hut also of the values of conjugal love" (p. 66). Chapter 5 deals with a wide range of theological issues: the biblical foundations for the teaching found in Humanae Vitae, the relevance of the concept of munus for this teaching, the possibility of acting " in good conscience " in a way contrary to its teaching, and the infallibility of the teaching. Of special value is the extended discussion of the con· cept expressed by the Latin term munus. Smith examines the rich meaning of this term in several magisterial documents, including Gaudium et Spes as well as Humanae Vitae. While a munus implies duties, it is essentially a noble, honor-bringing "gift" or "reward," signifying a vocation and sublime honor. Paul VI, in developing the integral vision of marriage in his encyclical, uses this concept to show that God, in giving to spouses the munus of handing on new life, has conferred on them the honor of sharing with him in the work of bring· 156 BOOK REVIEWS ing new life into the world. Smith shows beautifully how the rich theological meaning of this term helps " illuminate and enrich " the teaching of the encyclical. Chapters 6 and 7 investigate the arguments presented by dissenting theologians after Humanae Vitae to justify their repudiation of its teaching. In Chapter 6 Smith considers the views of Charles Curran and Bernard Haering, while in Chapter 7 she examines the proportionalist approach to moral issues developed by Joseph Fuchs, Richard McCormick and others. She provides intelligent criticism both of Curran and Haering and of proportionalist thought, focusing on the repudiation of specific moral absolutes. In Chapter 8 Smith provides a very helpful summary of Pope John Paul II's understanding of the human person, human sexuality and marriage. In particular, she takes up his notion that in marriage and in the act proper rto it man and woman make a " gift " of themselves to one another. Simultaneously to choose to give themselves to each other in the marital act and to contracept is then seen to involve an inner contradiction, a falsification of the " language of the body " (pp. 230258 ). Smith also takes up some of the major criticisms levelled against John Paul II's thought, in particular Lisa Sowle Cahill's, which charges him with an overromantic view of love and a failure to recognize that... (shrink)

Are we responsible for our misdeeds in dreams? The obvious answer would seem to be ‘No’. Dreams catch us with our defences down: just those critical and discriminative abilities which are distinctive of our waking lives as responsible moral agents seem out of play when we dream; el sueño de la razón produce monstruos . Moreover, if we are responsible for our dreamt misdeeds, then parity of reasoning demands that we be praised for dreaming noble dreams. But that is (...) absurd. Moral credit should not come that easily, and so neither should moral blame. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:William of Tyre, Livy, and the Vocabulary of ClassConor KostickThe most valuable source for the history of the early crusades and the Kingdom of Jerusalem is undoubtedly William of Tyre's A History of Deeds Done Beyond The Sea. A work of great scholarship and careful detail, it is particularly important in that William was Chancellor of the Kingdom of Jerusalem from 1174 and Archbishop of Tyre (...) from 1175 to his death c. 1185 and so was closely placed to the political decision making of the period. William was also a careful and highly educated scholar; although born in Jerusalem, he spent twenty years among the leading intellectuals of France and Italy and, after pursuing an avid interest in the liberal arts, devoted himself to civil law and the teachings of the masters at Bologna.1 In this respect William is far more than a narrator of crusading history, for which he would be highly regarded; he is also an important figure in the intellectual advances of the twelfth century. A close examination of William's vocabulary of social order shows that in his work he advanced the evolution of twelfth-century social concepts and also shed some light on the social structure of the Kingdom of Jerusalem.The History was commissioned by King Amalric of Jerusalem in 1167 and took its final form after redrafting by William in 1184, and it is clear that in his work William reveals a very rich vocabulary to describe social classes (see appendix). William actually uses the term classis to mean a social category of person. Current scholarship in history, sociology, and political theory would consider it anachronistic to talk about class in the twelfth century. Indeed, the use of classis as a term for social category must have been extremely rare as even such eminent scholars of lexicographers as Charles Dufresne Du Cange and Jan Frederik Niermeyer do not note it.Insofar as medieval writers before William discussed society, they referred to ordines, the orders of society. In the early part of the eleventh century even [End Page 353] the most advanced discussion of the subject of class had not progressed beyond the work of Adalbero, Bishop of Laon, and Gerard, Bishop of Cambrai, writing c. 1025, who had articulated the famous tripartite division of society according to function—those who pray, those who fight, and those who labor.2William uses the term ordo to mean order in the theological sense and ordines to indicate social order, but equally often he uses the term classis for the same purpose. For example, in describing the character of Baldwin III, he writes that "[Baldwin] acquired so great favor to himself from the commoners and the greater people that he was more popular with both classes [classis] than his predecessors."3 After the defeat of King Louis VII at Mount Cadmus, 7 January 1148, during the Second Crusade, William describes how the women fearfully cast about during for the return of fathers, lords, husbands, and sons: "and while they did not find what they sought they spent the night kept awake by the burden of their cares... nevertheless there returned in the night some of each of these classes [classis]."4Classis also appears in the phrase secundae classis homines, a phrase used three times to indicate a category of middle-class person. In describing the distant origins of the Hospitallers he says that it was a time when "there also flocked [to Jerusalem] some of the other nations, both nobles and the second class of men."5 At the fall of Balbis (3 November 1168) King Amalric's troops, "scarcely spared the old people and children, and were not any more merciful to the second class of persons."6 For his campaign beginning December 1170 the king's formidable opponent Saladin "increased his army with commoners and the second class of people."7 It is interesting to note that in these last two examples the term is referring to Muslim society, which William must have considered as socially diverse as his own. The existence and activity of a middle class of person as subjects of his history required William to use... (shrink)

Herbert Lionel Adolphus Hart was born in Yorkshire in 1907 to second generation Jewish immigrants. Having won a scholarship to Oxford University, he went on to become the most famous legal philosopher of the twentieth century. From 1932-40 H.L.A Hart practised as a barrister in London. He was pronounced physically unfit for military service in 1940, and was recruited by MI5, where he worked until 1945. During his time at the Bar he had continued to study philosophy and at M15 (...) his interest was further stimulated by his philosopher colleagues in M16, Stuart Hampshire and Gilbert Ryle. After the war, Hart returned to Oxford to take up a philosophy fellowship, later to become Professor of Jurisprudence. H.L.A Hart single-handedly reinvented the philosophy of law and influenced the nation's thinking in the 1960s on abortion, the legalization of homosexuality, and on capital punishment. Hart's approach to legal philosophy was at once disarmingly simple and breathtakingly ambitious, combining as it did the insights of Austin and Bentham and the new linguistic philosophy of J.L. Austin and Ludwig Wittgenstein. He sought to elucidate a concept of law which would be of relevance to all forms of law, wherever or whenever they arose: his bestselling book, The Concept of Law, has sold tens of thousands of copies worldwide. In 1941, he married Jenifer Williams (a high-ranking civil servant, later an Oxford academic) with whom he had four children. Their relationship was an enduring if unconventional one. In the early 1950s, Jenifer was rumoured to be having a long-standing affair with Isaiah Berlin, one of Hart's closest friends. She was also, falsely, accused by the Sunday Times of having been a Russian spy, an allegation which was all the more scandalous given Hart's position at MI5 during the War. Nicola Lacey draws on Hart's previously unpublished diaries and letters to reveal a complex inner life. Outwardly successful, Hart was in fact tormented by doubts about his intellectual abilities, his sexual identity and his capacity to form close relationships. Her biography also sheds fascinating light on the origins of his ideas, and assesses his overall contribution. Above all, it chronicles of a life which had a depth ands impact far greater than many of Hart's readers have realized. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Epistemic Leaks and Epistemic Meltdowns: A Response to William Morris on Scepticism with Regard to Reason Mikael M. Karlsson I. In an excellent paper which appeared in the April, 1989 issue of this journal,2 William Morris attemptsto demonstrate thatthe arguments which make up Hume's notorious chapter, "Of scepticism with regard to reason, are, in the first place, coherent—both internally and with the overall strategy of the Treatise—and, (...) in the second place, successful. Morris' paper is an exercise in the noble art of what I style constructive exegesis, an enterprise to which many readers of Hume Studies, and myself as much as any, are committed. It is a guiding principle ofthis art that we donotunderstandaphilosophical textuntil we can interpret it in such a way as to render it both coherent and correct. From this point ofview, coherence and correctness are not as independent of one another as they may seem to be to others who are differently committed. Some texts, such as Hume's chapter, "Ofscepticism with regard to reason," are notoriously resistant to constructive exegesis, despite the formidable bag of tricks which scholars and interpreters have developed; so resistant, that in gloomier moments we may be brought to wonder about our interpretative enterprise itself. Constructive exegesis is indeed a strange, and peculiarly optimistic, enterprise. Someday, I imagine, in a leisurely moment, I will think more reflectively about the principles ofour art. But not now.6 As a fellow practitioner of constructive exegesis, I am in full sympathy with what Morris tries to do in his paper; and I think that he does contribute substantially to our understanding of what Hume is up to in the chapter, "Ofscepticism with regard to reason." The third section of Morris' paper is, in my judgement, particularly successful in showing how Hume's chapter fits into the larger framework of the Treatise: Hume is, we see, attacking both what Morris labels "intellectualist rationalism" and its counterpart, which we may call 'unmitigated scepticism', although the chapter's two main arguments go primarily to the former. I also think that Morris gives very helpful, Volume XVI Number 2 121 MIKAEL M. KARLSSON and to my mind accurate, accounts of these two arguments, which I dub, respectively, the epistemic leak argument, and the epistemic meltdown argument. However, I have personally never found either of these arguments remotely convincing; and I still do not, despite Morris' clarification and defense. In what follows, I shall indicate some ofthe reasons for my dissatisfaction.?. Theepistemicleakargumentpurportsto"prove"(in Hume's sense)that reason or demonstration cannot support knowledge. Morris rightlyreminds us that whatHume meansby knowledge is perfect assurance or conviction: Knowledge is, in short, subjective certainty. This has caused confusion, for this is not what we usually mean nowadays by knowledge; nor was it what people, philosophers included, generally meant prior to Descartes. In Hume itis the product ofthe attempttoresolve all epistemic statesintomental eventsorwhat he calls "perceptions." In any case, we must—as Morris rightly explains—be clear that the epistemic leak argument is aimed at showing that demonstration cannot supportperfect conviction. Inoutline, the argumentissimple: Itworks, asMorrismakes clear, by shifting attention away from the subject-matter or "objects" of demonstration, that is, relations of ideas, to the exercise of demonstrative reason by human agents. The necessity of relations of ideas may suggest to us that we can be certain about them. Against this, one may point out that people do err in the conclusions arrived at by demonstration; this presumably shows that our (rational) understandingis fallible. And once we recognize this, our confidence in any conclusion produced by exercising this facultyislessened—thus do we move from knowledge, or subjective certainty, toprobability: belief, or imperfect conviction. Arguments ofthis general type (we can call them, using Descartes' famous figure, Totten-apple arguments ) were around long before Hume, although they were more commonly directed against the senses than against reason. We find them in antiquity—in Plato and Sextus Empiricus, for instance —and in Descartes, in parallel passages in the Discourse on Method, the First Meditation and the Principles of Philosophy, wherein one can discern a version directed precisely against reason and demonstration.12 To find out what, if anything, Hume has... (shrink)

On the centenary of Max Weber’s “Science as a Vocation,” his essay still performs interpretative work. In it, Weber argues that the vocation of a scientist is to produce specialized, rationalized knowledge that will be superseded. Weber says this vocation is a rationalized version of the Protestant conception of calling or vocation, tragically disenchanting the world and leaving the idea of calling as a worthless remains. A similar trajectory can be seen in the physician William Osler’s writings, especially his (...) essay “Internal Medicine as a Vocation,” in which the calling of a physician is described as both rational and noble. While Osler’s conception of the physician’s vocation has been formative for contemporary medicine, physicians are reporting burnout and leaving medical practice at escalating rates. As physicians abandon their noble vocations, an alternative conception of a physician’s vocation is needed. From the worthless remains of the physician’s rational and noble vocation, the labor of a physician can find grounding in humility. (shrink)

"The chief characteristic of poets," writes I. A. Richards in his well-known essay, "Science and Poetry," "is their amazing command of words".1 By this Richards does not mean that poetry can be written "by cunning and study, by craft and contrivance," that is, by "the technique of poetry added to a desire to write some"; his point is rather that "the ordering of the words" must spring from "an actual supreme ordering of experience." The true vocation of "genuine poetry" consists (...) in its attempt to give the reader "a response which is as passionate, noble and serene as the experience of the poet." It is, in other words, only by being "the master of experience" that a poet can be "the master of... (shrink)

We develop and apply a multi-dimensional conception of explanatory depth towards a comparative analysis of inflationary and bouncing paradigms in primordial cosmology. Our analysis builds on earlier work due to Azhar and Loeb (2021) that establishes initial condition fine-tuning as a dimension of explanatory depth relevant to debates in contemporary cosmology. We propose dynamical fine-tuning and autonomy as two further dimensions of depth in the context of problems with instability and trans-Planckian modes that afflict bouncing and inflationary approaches respectively. In (...) the context of the latter issue, we argue that the recently formulated trans-Planckian censorship conjecture leads to a trade-off for inflationary models between dynamical fine-tuning and autonomy. We conclude with the suggestion that explanatory preference with regard to the different dimensions of depth is best understood in terms of differing attitudes towards heuristics for future model building. (shrink)

The text of each poem is given in letterpress on the page facing the beautiful color reproductions of the plate. The book is printed on vellum.

Clinicians such as Sir William Osler reinvented Hippocrates and built the image of a noble, lone, professional man replete with black bag, minister...

Oliver Heaviside and Sir William Thomson stand in such contrast that the life of each serves to illuminate the life of the other. Thomson's talents, which were recognized at an early age, were cultivated with possibly unsurpassed educational opportunities, whereas Heaviside had scarcely any educational opportunities and was essentially self-taught. Nevertheless, Heaviside's published and unpublished works suggest that the breadth and depth of his learning were more or less comparable to Thomson's. Being an outstanding student at Cambridge brought Thomson (...) in contact with scientists of the first rank, and he learned without effort how to get along with his peers. That pleasing quality was essentially absent in Heaviside, whose personality was as prickly as a porcupine, almost without grace. But underneath this rough exterior was a noble genius who never exploited his rare talents to his own advantage, but instead dedicated them to learning the Truth for its own sake. As to personal temperament, educational opportunities, professional and social activities, Heaviside and Thomson were poles apart. But they maintained a correspondence which is significant, and Thomson's assistance to Heaviside is noteworthy. (shrink)

Book reviewed in this article: Beginning Lives, by Rosalind Hursthouse. On Moral Medicine:Theological Perspectives in Medical Ethics, edited by Stephen E. Lammers and Allen Verhey. Quantitative Risk Assessment, edited by James M. Humber and Robert F. A Theory of Value and Obligation, by Robin Attfield. Ethical Issues at the Outset of Life, edited by William B. Weil Jr. and Martin Benjamin. Legal Frontiers of Death and Dying by Norman L. Cantor Having Your Baby By Donor Insemination:A Complete Resource Guide, (...) by Elizabeth Noble. (shrink)

The Gifford Lectures were established in 1885 at the universities of St Andrews, Glasgow, Aberdeen and Edinburgh to promote the discussion of 'Natural Theology in the widest sense of the term - in other words, the knowledge of God', and some of the world's most influential thinkers have delivered them. The 1901–2 lectures given in Edinburgh by American philosopher William James are considered by many to be the greatest in the series. The lectures were published in book form in (...) 1902 and have been reprinted many times. James, who was educated in the United States and Europe, and spent much of his career teaching philosophy at Harvard, was very influential in the development of modern psychology, and in these twenty lectures he explores the personal experience of religion. Some of the topics include religion and neurology, 'the sick soul', saintliness, and mysticism. (shrink)

Autobiography and Teacher Development in China investigates the roles of autobiography in teacher education, as several scholars in China recontextualize Western conceptions of teacher development, combining them with uniquely Chinese cultural conceptions to articulate a reconceptualization of teacher development that holds worldwide significance. Framed by the work of Zhang Hua and William F. Pinar, these theoretical and practical essays point to an internationally inflected reconceptualization of teachers' professional development, pre-service and in-service. This volume addresses multiple movements of teacher education (...) reform worldwide, focused on crafting a nationally distinctive course not only internationally, but also culturally, historically, and locally. (shrink)

Cognitivism is now rather clearly the dominant approach in psychology. Philosophers such as Putnam (1975), Dennett (1978), Lycan (1981), and Cummins (1983) have supported the cognitivist strategy by proposing that mental states are to be defined functionally in terms of their interactions with other mental states. One of the most prominent features of the cognitivist-functionalist position is the autonomy it is thought to bestow upon psychology. Psychology, as viewed from this perspective, describes the processing of mental representations within the mind-brain (...) and does not need to concern itself with the neurological activity that underlies its operation.The arguments that are raised to support the autonomy of psychology from neurophysiology are arguments against a strong reductionist position that makes psychology dispensable (a view held, for example, by P.S. Churchland (1980)). The arguments are designed to show that there are regularities in nature that are not captured in the laws of physics. (shrink)

A spread of opinion from all points of the religious compass to provide readers with an overview of what each tradition, either collectively or through individual thinkers, has to say.

My purpose in this talk is to give an overview of the rediscovery of Frege's theorem together with certain of the issues that this rediscovery has raised concerning the evaluation of Frege's logicism—the ‘old doctrine’ of my title.The contextual definition of the cardinality operator, suggested in §63 ofGrundlagen— what, after George Boolos, has come to be known as Hume's principle—assertsThe number of Fs = the number of Gs if, and only if, F ≈ G,where F ≈ G (the Fs and (...) the Gs are in one-to-one correspondence) has its usual, second order, explicit definition. The importance of this principle for the derivation of Peano's second postulate (‘Every natural number has a successor’) was emphasized by Crispin Wright (1983, §xix) who presented an extended argument showing that, in the context of the system of second-order logic of Frege'sBegriffsschrift,Peano's second postulate is derivable from Hume's principle. (shrink)

The study of the Second Sophistic is a relative newcomer to the Anglophone field of classics, and much of what characterizes it temporally and culturally remains a matter of legitimate contestation. This Handbook offers a diversity of scholarly voices that attempt to define the state of this developing field. Included are chapters that offer practical guidance on the wide range of valuable textual materials that survive, many of which are useful or even core to inquiries of particularly current interest (e.g., (...) gender studies, cultural history of the body, sociology of literary culture, history of education and intellectualism, history of religion, political theory, history of medicine, cultural linguistics, intersection of the classical traditions and early Christianity). (shrink)

You are, I am sure, just as aware as I am that the operational nodes of a complex problem, the points at which it can be split open to yield nuggets of new insight or achieve lasting advances, often lie in tediously technical details perhaps incomprehensible to all but specialists in the matter and anyways totally lacking in the romance and easy excitement which attract the topic's dilettantes. I would like you to hold fast to this appreciation, for the concerns (...) I shall raise here are technical indeed. They are, however,seminaltechnicalities which, as we seek to fathom them, should fundamentally reshape our comprehension of the logic of confirmation, causal connectedness, and the foundations of statistical inference. In brief, it will be seen that certain powerful everyday intuitions concerning which propositions are confirmationally irrelevant to which others are exceedingly difficult to justify. (shrink)

Animal behaviour and welfare research are part of a wider endeavour to optimize the health and wellbeing of humans, animals and ecosystems. As such, it is part of the One Health research agenda. This article applies ethical principles described by the One Health High Level Expert Panel to animal behaviour and welfare research. These principles entail that animal behaviour and welfare research should be valued equitably alongside other research in transdisciplinary and multisectoral collaboration. It should include and promote a multiplicity (...) of marginalized voices, including those of animals, and it should apply and describe a harmonious balance between human—animal-environment interactions. Lastly, it should describe how humans need to change behaviour, adopt sustainable solutions and recognize the importance of animal welfare and the integrity of the whole ecosystem. (shrink)