Plasmodium falciparum is the most deadly human malarial parasite, responsible for an estimated 207 million cases of disease and 627,000 deaths in 2012. Recent studies reveal that the parasite actively regulates a large fraction of its genes throughout its replicative cycle inside human red blood cells and that epigenetics plays an important role in this precise gene regulation. Here, we discuss recent advances in our understanding of three aspects of epigenetic regulation in P. falciparum: changes in histone modifications, nucleosome occupancy (...) and the three‐dimensional genome structure. We compare these three aspects of the P. falciparum epigenome to those of other eukaryotes, and show that large‐scale compartmentalization is particularly important in determining histone decomposition and gene regulation in P. falciparum. We conclude by presenting a gene regulation model for P. falciparum that combines the described epigenetic factors, and by discussing the implications of this model for the future of malaria research. (shrink)

Infants are sensitive to statistics in spoken language that aid word‐form segmentation and immediate mapping to referents. However, it is not clear whether this sensitivity influences the formation and retention of word‐referent mappings across a delay, two real‐world challenges that learners must overcome. We tested how the timing of referent training, relative to familiarization with transitional probabilities (TPs) in speech, impacts English‐learning 23‐month‐olds’ ability to form and retain word‐referent mappings. In Experiment 1, we tested infants’ ability to retain TP information (...) across a 10‐min delay and use it in the service of word learning. Infants successfully mapped high‐TP but not low‐TP words to referents. In Experiment 2, infants readily mapped the same words even when they were unfamiliar. In Experiment 3, high‐ and low‐TP word‐referent mappings were trained immediately after familiarization, and infants readily remembered these associations 10 min later. In sum, although 23‐month‐old infants do not need strong statistics to map word forms to referents immediately, or to remember those mappings across a delay, infants are nevertheless sensitive to these statistics in the speech stream, and they influence mapping after a delay. These findings suggest that, by 23 months of age, sensitivity to statistics in speech may impact infants’ language development by leading word forms with low coherence to be poorly mapped following even a short period of consolidation. (shrink)

It is common to designate Lamarck and Lamarckism as the main historical references for conceptualizing the relationship between organisms and the environment. The Lamarckian principle of the inheritance of acquired characters is often considered to be the central aspect of the “environmentalism” developed in this lineage, up to recent debates concerning the possible Lamarckian origins of epigenetics. Rather than focusing only on heredity, this article will explore the materialist aspect of the Lamarckian conception of the environment, seeking to highlight that (...) the life-supporting function of physicochemical milieux was its cornerstone. Indeed, compared to the Darwinian conception of the environment, which focuses on interindividual and interspecific relationships in a given habitat, Lamarck’s emphasis on the dependencies of organisms on physicochemical environments appears to have given rise to a very active philosophical environmentalism. Studying the environmental Lamarckism of 19th-century philosophers and social scientists in France, Great Britain, and the United States, such as Comte, Quatrefages, Spencer, and Ward, I propose to analyze their contribution to the conceptualization of the environment. The social, moral, or psychological conceptions of human environments that proliferated in the second half of the 19th century deviated from Lamarck’s more material approach, but they were still referencing Lamarck. Examining the scope of their “Lamarckism,” this article seeks to highlight the common context of life sciences and social philosophy, in which the environment emerged as a central issue in the 19th century. (shrink)

It is common to designate Lamarck and Lamarckism as the main historical references for conceptualizing the relationship between organisms and the environment. The Lamarckian principle of the inheritance of acquired characters is often considered to be the central aspect of the “environmentalism” developed in this lineage, up to recent debates concerning the possible Lamarckian origins of epigenetics. Rather than focusing only on heredity, this article will explore the materialist aspect of the Lamarckian conception of the environment, seeking to highlight that (...) the life-supporting function of physicochemical milieux was its cornerstone. Indeed, compared to the Darwinian conception of the environment, which focuses on interindividual and interspecific relationships in a given habitat, Lamarck’s emphasis on the dependencies of organisms on physicochemical environments appears to have given rise to a very active philosophical environmentalism. Studying the environmental Lamarckism of 19th-century philosophers and social scientists in France, Great Britain, and the United States, such as Comte, Quatrefages, Spencer, and Ward, I propose to analyze their contribution to the conceptualization of the environment. The social, moral, or psychological conceptions of human environments that proliferated in the second half of the 19th century deviated from Lamarck’s more material approach, but they were still referencing Lamarck. Examining the scope of their “Lamarckism,” this article seeks to highlight the common context of life sciences and social philosophy, in which the environment emerged as a central issue in the 19th century. (shrink)

The English School analytical framework concerning theformation of order in international relations posits that states establish orderthrough rules and institutions within the framework of common interests andvalues to protect against anarchy. State-centred orders with limited civil societycooperation are pluralistic, while their converse are solidarist. The Association of Southeast Asian Nations was established in 1967 by Malaysia, Thailand, the Philippines, Singapore,and Indonesia based on common interests, such as strengthening sovereigntyand creating stable relations in the face of anarchic problems like communismand internal (...) instability. In numerous conventions ASEAN has adopted variousnorms, such as respect for the sovereignty of the states, the rule of law, non-useof power, peaceful resolution of disputes, and non-interference in other states.All these norms showed that the primary purpose of ASEAN is to protect statesovereignty and interests and to establish peaceful regional relations. The factthat state sovereignty is at the forefront, with limited cooperation of non-stateactors, shows that the ASEAN regional order is pluralist. This article analysesthe emergence and appearance of the ASEAN regional order in the context of the ES. (shrink)

It is widely assumed that theism is superior to metaphysical naturalism in explaining moral phenomena, especially with regard to the practical aspect of morality. In this article, I will firstly clarify what this practical aspect amounts to and present two challenges against metaphysical naturalism, by John Mackie and Richard Joyce. Then, I will critically engage with two main attempts to argue for the superiority of theism over metaphysical naturalism: One of them is the appeal to the existence of afterlife, and (...) the other is Robert Merrihew Adams’ divine command metaethics. I will argue that both are problematic for different reasons. Relying on the main aspects of Adams’ metaethical framework, I will advance my proposal to maintain the practical aspect of morality which lends theism superiority over metaphysical naturalism, and then follow with certain implications of the proposal for theistic metaethics. (shrink)

Las fuentes hagiográficas de la Edad Media presentan un catálogo impresionante de enfermedades, pues Dios pone a prueba a sus fieles por medio de males espectaculares, signos visibles de la elección divina. Por su parte, el santo está en lucha perpetua con su cuerpo: vestidos que hieren la piel, privaciones de alimento, de sueño y de cualquier placer. A pesar de la debilidad física producida por estas privaciones y enfermedades, las capacidades de estos cuerpos son impresionantes. Cuanto más se domina (...) el cuerpo, más se domina el mundo material y más espectaculares son los milagros. El artículo examina también las virtudes y carisma del cuerpo muerto del santo y de su lugar de enterramiento, así como la relación entre maestro y discípulo, fuertemente emocional y casi física. (shrink)

Este artículo intenta demostrar la falta de sacralidad de los soberanos magrebíes, a los que no se atribuye ningún tipo de poder taumatúrgico o milagroso. Antes bien, el poder es considerado como algo pernicioso, sujeto siempre a la oposición de los círculos religiosos, santos y alfaquíes, oposición que se resuelve en el rechazo del contacto con el sultán o en las críticas a la fiscalidad del Majzan.

Tanrısal ön bilgi-özgür irade sorununa ilişkin Ockhamcı çözümler, 1960’lı yıllardan 1990’lı yıllara kadar analitik din felsefesi çevrelerinde önemli bir yer tutmuştur. Bu çalışmada, Ockhamlı William’ın geleceğe ilişkin olumsal önermeler ve tanrısal ön bilgi-özgür irade sorununa ilişkin görüşlerine kısaca değinildikten sonra, çağdaş analitik din felsefesinde tanrısal ön bilgi-özgür irade sorununa ilişkin Ockhamcı çözüm olarak adlandırılan görüş ve buna ilişkin tartışmalar ele alınacaktır. Bu kapsamda Ockhamcı çözüm olarak savunulan görüşlerin tanrısal ön bilgi ile insan özgür iradesini bağdaştırma açısından başarısız olduğu gösterilecektir. Ayrıca, (...) Ockhamcı çözümlerin geleceğe ilişkin olumsal önermeler konusunda varsaydığı görüşün karşılaştığı metafiziksel sorun ortaya konacak ve bu sorunun, tanrısal ön bilgi ile özgür iradeyi bağdaştırmaya yönelik herhangi bir girişim açısından sorun oluşturduğu vurgulanacaktır. (shrink)

Open Theist theologians argue that their view of divine foreknowledge and providence is the correct interpretation of the Bible, and suggest some biblical evidence to support this claim. Among these theologians, Gregory A. Boyd’s case is the most systematic, and also the most comprehensive and rigorous. Taking into consideration (1) the main philosophical claims of Open Theism and its main rivals, namely Calvinism and Molinism, and (2) Open Theist theologians’ interpretative principles for the Bible, the biblical evidence for Open Theism (...) suggested by Boyd can be classified into three groups according to their strength. I will argue that the first group of themes has no evidential value for Open Theism, since these themes can be interpreted just as plausibly from a Calvinist or Molinist perspective. By contrast, the second group of themes has some evidential value and thus constitutes prima facie evidence for Open Theism, since these themes make most sense under an Open Theist interpretation. However, these themes also make some sense on a Molinist reading. The third group of themes, I argue, has most evidential value for Open Theism, since it seems hard to reconcile these themes either with Calvinism or Molinism. (shrink)

Maʼamar "Hatsileni mi-pezur ha-nefesh": a praḳṭishe hilf far meḥankhim, elṭern, mener un froyen ... -- Derashat hitḥazḳut be-ʻinyan "ahavat ḥaverim" -- Yalḳuṭ igrot u-mikhtavim : liḳuṭ amarim u-khetavim, ratsuf be-tokham niṭfe ḥizuḳ ... .

Background:Attitudes of nurses towards death and related concepts influence end-of-life care. Determining nurses’ views and attitudes towards these concepts and the factors that affect them are necessary to ensure quality end-of-life care.Objectives:The purpose of this study was to determine nurses’ views and attitudes about death, dying patient, euthanasia and the relationships between nurses’ characteristics.Methods:Participants consist of the nurses who volunteered to take part in this descriptive study from 25 hospitals which has a paediatric or adult intensive care unit and located (...) within the boundaries of Ankara, Turkey. ‘Nurse Information Form’ and ‘Attitude Scale about Euthanasia, Death and Dying Patients ’ were used as data collection tool.Ethical consideration:Written permissions were received from the ‘Noninterventional Clinical Researches Ethics Board’ of authors’ university and education councils of each hospital. Informed consent was obtained from participants.Findings:It is found that there are statistically significant difference among the factors of marital status, having a child, years of experience, bereavement experience, affected by working with dying patient, definition of euthanasia, views about patients who are appropriate for euthanasia, views about patients who desire to die and feeling need for counselling on these concepts according to the mean total score of nurses’ attitudes about euthanasia, death and dying patient.Conclusion:The results indicate that nurses are negatively affected to face the concepts of death, euthanasia and work with dying patient. This is reflected in their attitude. In order to gain positive attitude towards death, dying patient and euthanasia, the implementation of training and consulting services to nurses at appropriate intervals during both education and professional life are required. (shrink)

Research suggests that organizational justice has important impacts on work-related attitudes and behaviors, such as organizational citizenship behavior. In this article, we explore the extent to which individualism moderates the relationship between organizational justice and OCB among citizens in Kyrgyzstan. We make additional contributions to the literature because we know very little about these constructs in this former Soviet Union country, Kyrgyzstan, an under-researched and under-represented region of the world. Results of our data collected from 402 managers and employees in (...) Kyrgyzstan offer the following new discoveries. All three justice constructs are related to OCB. Individualism moderates only the distributive and interactive justice to OCB relationships. We develop an intricate theory with provocative implications: Procedural justice produces obedience. For “individualists,” interactional justice inspires loyalty and, interestingly, distributive justice “can only buy” participation, but “can’t buy” loyalty. Therefore, for individualists, interactional justice outweighs distributive justice for organizational loyalty. Based on Kyrgyz citizens’ justice, OCB, and individualism, our theory reveals novel insights regarding culture, money attitude, and intrinsic motivation and provides critical and practical implications to the field of business ethics. (shrink)

A variety of semiotic resources makes the construction of scientific knowledge possible and meaning-making resources are conveyed by certain semiotic modes. Next, numerous studies have demonstrated the pedagogical importance of gestures in the demonstration of scientific knowledge in the classroom. Drawing on social semiotic systemic functional theory and legitimation code theory, this study explores the types and the role of gestures in the semiotic construction of scientific knowledge in pedagogic semiosis and their pedagogical values for the meaning-making of science content. (...) With this aim, a gesture observation protocol (GOP) is developed to annotate and analyze data. Two science lectures, which are broadcast remotely for middle school students including gifted students, are observed. Systemic Functional Multimodal Discourse Analysis (SF-MDA) method is employed to analyze and evaluate data. Results demonstrated that the deployment of gestures that contributes to the construction of scientific knowledge is low and deployed gestures mostly do not have pedagogical value. It is recommended that teachers should be more conscious and educated about deploying gestures to present scientific knowledge efficiently. (shrink)