Cognitive Science, Volume 46, Issue 5, May 2022.

Plasmodium falciparum is the most deadly human malarial parasite, responsible for an estimated 207 million cases of disease and 627,000 deaths in 2012. Recent studies reveal that the parasite actively regulates a large fraction of its genes throughout its replicative cycle inside human red blood cells and that epigenetics plays an important role in this precise gene regulation. Here, we discuss recent advances in our understanding of three aspects of epigenetic regulation in P. falciparum: changes in histone modifications, nucleosome occupancy (...) and the three‐dimensional genome structure. We compare these three aspects of the P. falciparum epigenome to those of other eukaryotes, and show that large‐scale compartmentalization is particularly important in determining histone decomposition and gene regulation in P. falciparum. We conclude by presenting a gene regulation model for P. falciparum that combines the described epigenetic factors, and by discussing the implications of this model for the future of malaria research. (shrink)

Economics is probably the most subtle, precise and powerful of the social sciences and its theories have deep philosophical import. Yet the dominant alliance between economics and philosophy has long been cheerfully simple. This is the textbook alliance of neo-Classicism and Positivism, so crucial to the defence of orthodox economics against by now familiar objections. This is an unusual book and a deliberately controversial one. The authors cast doubt on assumptions which neo-Classicists often find too obvious to defend or, indeed, (...) to mention. They set out to disturb an influential concensus and to champion an unpopular cause. Although they go deeper into both philosophy and economics than is usual in interdisciplinary works, they start from first principles and the text is provokingly clear. This will be a stimulating book for all economic theorists and philosophers interested in the philosophy of science and social science. (shrink)

Randomized controlled trials are often considered the gold standard for estimating causal effect, but they may lack external validity when the population eligible to the RCT is substantially different from the target population. Having at hand a sample of the target population of interest allows us to generalize the causal effect. Identifying the treatment effect in the target population requires covariates to capture all treatment effect modifiers that are shifted between the two sets. Standard estimators then use either weighting, outcome (...) modeling, or combine the two in doubly robust approaches. However, such covariates are often not available in both sets. In this article, after proving L 1 {L}^{1} -consistency of these three estimators, we compute the expected bias induced by a missing covariate, assuming a Gaussian distribution, a continuous outcome, and a semi-parametric model. Under this setting, we perform a sensitivity analysis for each missing covariate pattern and compute the sign of the expected bias. We also show that there is no gain in linearly imputing a partially unobserved covariate. Finally, we study the substitution of a missing covariate by a proxy. We illustrate all these results on simulations, as well as semi-synthetic benchmarks using data from the Tennessee student/teacher achievement ratio, and a real-world example from critical care medicine. (shrink)

There is a bustling, fluorescent clamor that governs hospital hallways during the day and so fills the air that any sound wanting attention has to vie for it, each alarm louder and more cacophonous than the last. But at night, an altogether different temper settles over the hospital. A restrained, low-lit quiet descends, transforming those long corridors into a space that seems smaller and almost comforting. Almost any sound stands out at night. I was once trudging down one of those (...) subdued nighttime hallways after many busy hours on call, allowing the glimpse of sleeping patients in each passing room to give me hope for a nap that night, too. My head was down and my thoughts were elsewhere, but the .. (shrink)

Cruelty is the deliberate infliction of physical or psychological pain on other living creatures, sometimes indifferently, but often with delight. Though cruelty is an overwhelming presence in the world, there is no neurobiological or psychological explanation for its ubiquity and reward value. This target article attempts to provide such explanations by describing three stages in the development of cruelty. Stage 1 is the development of the predatory adaptation from the Palaeozoic to the ethology of predation in canids, felids, and primates. (...) Stage 2, through palaeontological and anthropological evidence, traces the emergence of the hunting adaptation in the Pliocene, its development in early hominids, and its emotional loading in surviving forager societies. This adaptation provides an explanation for the powerful emotions – high arousal and strong affect – evoked by the pain-blood-death complex. Stage 3 is the emergence of cruelty about 1.5 million years ago as a hominid behavioural repertoire that promoted fitness through the maintenance of personal and social power. The resulting cultural elaborations of cruelty in war, in sacrificial rites, and as entertainment are examined to show the historical and cross-cultural stability of the uses of cruelty for punishment, amusement, and social control. Effective violence prevention must begin with perpetrators, not victims. If the upstream approaches to violence prevention advocated by the public-health model are to be effective, psychologists must be able to provide violence prevention workers with a fine-grained understanding of perpetrator gratifications. This is a distasteful task that will compel researchers to interact with torturers and abusers, and to acknowledge that their gratifications are rooted in a common human past. It is nonetheless an essential step in developing effective strategies for the primary prevention of violence. Key Words: compassion; cruelty; entertainment industry; evolutionary psychology; intraspecific killing; pain; predation; punishment; torture; violence prevention. Correspondence:c1 Correspondence to: West Hill House, 6 Swains Lane, Highgate, London N6 6QS, United Kingdom. (shrink)

Since 1991 government has harnessed mass media resources to tackle the problem of physical and sexual abuse, aiming its media messages specifically at men as potential perpetrators. This article examines the ways this new state responsibility has taken shape. The central theme here is the role played by women's studies as intermediary between feminist action and government policy. It looks at how physical and sexual abuse became part of the parliamentary political agenda and how a political and policy basis was (...) created. A guiding role was played by representative research commissioned by government on sexual abuse of girls and violence in heterosexual relationships. Data on the extent of the problem generated surprise and concern among the general public and downright disbelief in the press. Yet, government continued to pursue policy development, supported by the clearly demonstrated extensive physical and sexual abuse. One decisive result of the representative research – the relationships or family dynamics interwoven with violence – remained less easy to tackle through government policy. The more precise questions subsequently posed by women's studies on specific relationships and situations in which women can be affected by violence are re ected in government policy aimed at groups of women at risk. Those elements which apply to potential victims also apply to potential perpetrators. Here again, sociopsychological research among perpetrators has been initiated whereby sexual violence as an element of everyday reality becomes more transparent. These studies emphasize the significance of a dominant heterosexual pattern and the relationship dynamic this implies, and as such re ects the first representative studies. This concept has ultimately been incorporated into the mass media information programmes initiated by government. (shrink)

Despite a wealth of prior research, little consensus has arisen about the goals and effectiveness of business ethics education. Additionally, accounting academics have recently been questioned as to their commitment to accounting ethics education. The current study examines whether accounting students' perceptions of business ethics and the goals of accounting ethics education are fundamentally different from the perceptions of accounting faculty members. The study uses a survey instrument to elicit student and faculty responses to various questions concerning the importance of (...) business ethics and accounting ethics education. Statistical analyses indicate that students consider both business ethics and the goals of accounting ethics education to be more important than faculty members. Implications of these results for accounting faculty members interested in accounting ethics education are discussed. (shrink)

The aim of this note is to determine whether certain non-o-minimal expansions of o-minimal theories which are known to be NIP, are also distal. We observe that while tame pairs of o-minimal structures and the real field with a discrete multiplicative subgroup have distal theories, dense pairs of o-minimal structures and related examples do not.

The aim of this work is an analysis of distal and non‐distal behavior in dense pairs of o‐minimal structures. A characterization of distal types is given through orthogonality to a generic type in, non‐distality is geometrically analyzed through Keisler measures, and a distal expansion for the case of pairs of ordered vector spaces is computed.

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 61.3 (2000) 473-492 [Access article in PDF] Sainte-Beuve between Renaissance and Enlightenment Paul Nelles For a period of eight years in the 1840s Charles-Augustin de Sainte-Beuve held a post of conservateur at the Bibliothèque Mazarine. 1 Each day he traversed the gallery of hommes illustres which decorated the reading room. This held busts of major figures from history and literature. In one of (...) his portraits littéraires from these years Sainte-Beuve pretended to derive inspiration from this legion of intellectual heroes. Among the busts stood one of Gabriel Naudé, Mazarin's first librarian in the 1640s. Sainte-Beuve dreamt, he wrote at the time, of placing Naudé's bust beside that of Charron, or even better, between those of Montaigne and Bayle. Through Naudé, Sainte-Beuve avowed to discover the genius loci of the Bibliothèque Mazarine. Yet whatever local reasons there were for the presence of Naudé's bust at the Mazarine, Sainte-Beuve set out in this essay to find a place for Naudé among the pantheon of French thinkers on his own merits. Such playfulness with a biographical conceit of both the literary and visual arts belied serious purpose. If it fuelled Sainte-Beuve's claim to have found in the seventeenth-century thinker "un sceptique moraliste sous masque d'érudit," 2 it was also expressive of a critical campaign devoted to the revision of a received tradition of French thought and learning. Sainte-Beuve [End Page 473] juxtaposed a seventeenth-century tradition of "literary" skepticism independent of formal philosophy with an Enlightenment inheritance he was eager to disown. Central to this task was a disciplinary turn away from philosophical inquiry and the history of philosophy to literary history. This in turn entailed a full embrace of the shadowy inhabitants of the margins of pre-Enlightenment thought from the late Renaissance to Bayle.Sainte-Beuve's discovery of seventeenth-century precursors, as he clearly regarded them, was first sketched in a series of articles in the Revue des Deux Mondes in the 1830s and 1840s. Naudé was thus somewhat more than a random sighting in Sainte-Beuve's critical galaxy. Together with Bayle and a handful of other figures Naudé occupied a key position within the constellation of thinkers Sainte-Beuve charted in plotting a course for the practice of literary history and criticism in the middle years of the nineteenth century. The context of the development of Sainte-Beuve's enterprise illuminates an intriguing aspect of the historiography of skepticism in modern intellectual history. While functioning in part to legitimize literary history as a discipline, the circumstances of Sainte-Beuve's undertaking are rooted in wider contemporary currents of historiography and the philosophy of history. There is, then, a crucial disjuncture between the tradition Sainte-Beuve set out to describe and that established in the twentieth century under the rubric of libertinage. Sainte-Beuve did not seek to establish seventeenth-century origins for Enlightenment free thought. Rather, he turned to the seventeenth century in an effort to exhume a tradition of criticism and literary skepticism with which, on his account, the Enlightenment had openly broken. 3Sainte-Beuve's interest in Naudé, Bayle, and other figures derived from a need to differentiate the orientation and method of literary history from contemporary mechanisms for assessing the significance of France's intellectual and cultural heritage. For all concerned this was a heritage unquestioningly viewed through the prism of the political events of 1789 and their aftermath. According to Sainte-Beuve, la critique emerged in the seventeenth century with thinkers such as Charron, Naudé, and Bayle. From his standpoint, the significance of such figures inhered entirely in their pre-Enlightenment status. They vividly illustrate how the Enlightenment had deviated from a well-established tradition of la critique. The degree to which they served as a foil to the Enlightenment becomes evident when contrasted with Sainte-Beuve's characterization of mainstream Enlightenment figures. [End Page 474]For Sainte-Beuve and his contemporaries literature was not yet restricted to a narrow canon... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reclaiming the Works of Early Modern Women Authorship, Gender, and Interpretation in the Nouveau recueil de lettres des dames de ce temps (1635)1Aurora Wolfgang (bio) and Sharon Diane Nell (bio)Reclaiming the forgotten texts of women writers has been a major feminist undertaking of the last half-century. Indeed, believing in the importance of this sort of work, we have each spent much of our careers studying the women writers absent (...) from our own graduate-school education. What follows, however, is a cautionary tale about discovery and reclamation: first, our discovery of what we thought was a hitherto-neglected text by eminent seventeenth-century writer Madeleine de Scudéry—her Lettres amoureuses de divers auteurs de ce temps (1641); second, our discovery that the text was not (even as indexed in Gerritsen Collection of Women’s History microfilm collection) authored by Scudéry but was written instead by a Franciscan priest, Jacques Du Bosc. Clearly, our second discovery pointed out both our own rush to judgment as well as that of other literary scholars interested in the tenuous project of historical reclamation. In this essay, we seek to explore the implications of attribution and authorship for our cautionary tale. Does the fact that a work is not Scudéry’s Lettres amoureuses but instead Du Bosc’s Nouveau recueil de lettres des dames de ce temps (1635) diminish its importance to the history of women’s letters?The First DiscoveryWe became interested in Scudéry’s Lettres amoureuses because of a brief description of the text in Joan DeJean’s Tender Geographies, a pioneering study of women novelists of the seventeenth century. DeJean describes a one-volume work that constituted the first publication of one of the most important writers of the seventeenth century, Madeleine de Scudéry. This work was a reversal of and “forceful response to” the so-called Ovidian model of epistolary fiction in which a “seduced and abandoned” woman complains in letter form about the infidelity of her male lover. In Scudéry’s text, however, men wrote long letters complaining about the women who did not reciprocate their love (DeJean, Tender Geographies 79).We obtained a copy of the Lettres amoureuses from the Women’s History microfilm collection, which was created in the 1970s (published 1983) in order to make available [End Page 1] an extensive array of texts and documents relating to women’s lives. We were surprised to see that all of the letters in the Lettres amoureuses were written by women—not men. Moreover, most of the letters were written by women to other women. No letters by men were included at all. Our copy of Lettres amoureuses contained letters and responses written between women, meant to show the excellence of women’s writing skill. The letters discussed and debated a wide variety of topics of interest to seventeenth-century French women; more strikingly, however, they reflected a close-knit homosocial world of women who openly expressed love, devotion, desire, and longing for each other’s company.Given the differences between our copy of Lettres amoureuses and the text described by DeJean, we wondered if we were looking at the same book. Was our collection the one to which DeJean referred? Yes and no. In another DeJean article about the Lettres amoureuses, we discovered that DeJean had used a particular copy of the text, one found in the holdings of Harvard’s Houghton Library. Upon first obtaining a microfilm copy of the Houghton volume, and later examining the physical book itself in Houghton’s rare books room, we saw that it (unlike our own copy) did indeed contain only letters by men who complain about their female beloveds. At this point, we thought we had discovered a second volume to Scudéry’s work: it seemed clear to us that the Lettres amoureuses had been halved at some point in the last several centuries and that we had a chance to reunite the volumes. After all, the preface in the Houghton volume tells the reader, “Si vous receuez fauorablement ce volume, ie vous en prepare un second” [“If you receive this volume favorably, I will prepare a second one... (shrink)

Like other early modern missionaries, the Jesuits made much of their status as eye?witness observers, but the observational methods which missionaries employed in gaining knowledge of non?European cultures have received little consideration. The Jesuit case affords a glimpse of the observational tools and cognitive practices deployed in the overseas missions. Prayer, reading and some kind of writing or annotation constituted the backbone of Jesuit devotional practice, and writing formed a routine component of Jesuit mission life. Notes played an essential role (...) in bringing order to the onslaught of new experiences, alien customs, unfamiliar languages and unexpected circumstances routinely encountered. (shrink)

This response deals with seven of the major challenges the commentators have raised to the target article. First, I show that the historical-anecdotal method I have followed has its roots in sociology, and that there is a strong case for the development of a “psychology of history.” Next, the observational data suggesting that intentional cruelty cannot be restricted to humans is rebutted on the grounds that cruelty requires not only an intention to inflict pain, but to do so because that (...) pain would cause the victim to suffer – which requires a theory of mind. Third, in the light of the commentaries, I recognise that not only predation but also intraspecific aggression contributes to the development of cruelty. Fourth, I contrast nativists and environmentalists, the former regarding cruelty as a universal human capacity and the latter holding the view that cruelty is acquired through social learning, and argue that there is an otherworldly quality to the environmentalist view. I then show (the fifth challenge) that the target article does generate testable hypotheses. Sixth is a consideration of the implications of the target article for the re-admission of the concept of evil to the psychological lexicon; and seventh, a consideration of the commentaries which note that the cultivation of compassion is a tool for the prevention of cruelty. The last section of the response replies to questions of detail and rebuts some misrepresentations of my argument. Correspondence:c1 Correspondence to: West Hill House, 6 Swains Lane, Highgate, London N6 6QS, United Kingdom. (shrink)

First published in 1984, this book carefully dissects and convincingly demonstrates that conservative economics is incoherent in theory and disastrous in practice. The three main schools of thought supporting "free-market" policies – supply side economics, monetarism and rational expectations – are examined in turn and each is found defective. Three case studies of conservative policy in action follow: Reagan’s U.S., Thatcher’s U.K. and Pinochet’s Chile and their courses are charted in depth. In addition, Robert Heilbroner and Edward Nell analyse economic (...) conservatism’s ideology and social policy, and the book concludes with an assessment of the political reasons for the continuing appeal of free-market conservatism despite its theoretical incoherence and practical failure. This is a careful and comprehensive look at this subject which tackles both the theory and the practice head-on. It will make useful and stimulating reading for students of economics and political economy on courses of economic policy and macro-economics and in addition will be of keen interest to all those involved in the debate about one of the major policy issues of our time. (shrink)

The Streptococcus pyogenes CRISPR‐Cas system has gained widespread application as a genome editing and gene regulation tool as simultaneous cellular delivery of the Cas9 protein and guide RNAs enables recognition of specific DNA sequences. The recent discovery that Cas9 can also bind and cleave RNA in an RNA‐programmable manner indicates the potential utility of this system as a universal nucleic acid‐recognition technology. RNA‐targeted Cas9 (RCas9) could allow identification and manipulation of RNA substrates in live cells, empowering the study of cellular (...) gene expression, and could ultimately spawn patient‐ and disease‐specific diagnostic and therapeutic tools. Here we describe the development of RCas9 and compare it to previous methods for RNA targeting, including engineered RNA‐binding proteins and other types of CRISPR‐Cas systems. We discuss potential uses ranging from live imaging of transcriptional dynamics to patient‐specific therapies and applications in synthetic biology. (shrink)

Eleventh-century Europe was dominated by a single political and economic elite with position based on control of the means of coercion; by the end of the fifteenth. century there were various elites with power based on control of some form of production. Theories based on trade, population, and the class struggle have been advanced to account for this change but are inadequate because they posit causal relationships running from some single independent factor. A different form of explanation emphasizes the network (...) of relationships among economic and political units. Here economic power is crucial. The development of new technology shifted the economic leverage of the nobility to the mer chants, then to town craftsmen, with detailed effects on all other economic relationships. The argument is primarily theoretical, not a reconstruction of events, and a mathematical model is provided. (shrink)

Dominic Smith’s Exceptional Technologies has a specific project, a bridge it is hoping to build, between a philosophy of technology which has become too standardised and a continental tradition tha...

The large number of xenophobic attacks that broke out in different places in South Africa during 2008 was still continuing unabated 10 years later. We were stressed to come to terms with the reality that this occurred in a country that is globally considered to be an example of reconciliation. It is clear that we were confronted by the politics of fear, which were manifested in xenophobia and all the other -isms. In this article, the primary causes of these xenophobic (...) outbreaks were scrutinised and placed within the wider framework of a culture of fear. The central research question is: Why are we still struggling with this phenomenon more than a decade after it first appeared on South African soil? In-depth analysis will be performed on what is lying behind the culture of fear underlying these acts of violence. After exploring some of the factors related to a culture of fear by making use of a sociological frame, the author moved on to answer a second question: How do we, as preachers, researchers and practical theologians, respond in a theological way to the challenges posed by a xenophobic culture in our preaching activities? Finally, the impact of violence and fear on the practice of preaching within a Christian context was discussed. (shrink)