Tumour‐associated genetic changes frequently involve DNA translocation or deletion. Many of these events will have arisen from initial genomic damage, induced by either the activity of endogenous metabolic processes or from exposure to environmental genotoxic agents. Although initial genomic damage will have been widely distributed, tumorigenic events are confined to certain DNA target sites. Furthermore, within these target sites there appear to be regions of preferential DNA rearrangement, and examination of these sites implies that the location and extent of such (...) rearrangement may be influenced by DNA primary and secondary structure rather than simply by the point of damage. We selectively review evidence relating to DNA structures that may predispose certain regions of the genome to damage‐induced rearrangement, and discuss the possible role of interstitial, inverted telomere‐like sequence arrays in promoting chromosomal events of a type known to be associated with some human and animal tumours. (shrink)

Which political principles should govern global politics? In his new book, Simon Caney engages with the work of philosophers, political theorists, and international relations scholars in order to examine some of the most pressing global issues of our time. Are there universal civil, political, and economic human rights? Should there be a system of supra- state institutions? Can humanitarian intervention be justified?

State-reduction and the notion of actuality are compared to passage through time and the notion of the present; already in classical relativity the latter give rise to difficulties. The solution proposed here is to treat both tense and value-definiteness as relational properties or facts as relations; likewise the notions of change and probability. In both cases essential characteristics are absent: temporal relations are tenselessly true; probabilistic relations are deterministically true. The basic ideas go back to Everett, although the technical development (...) makes use of the decoherent histories theory of Griffiths, Omnès, and Gell-Mann and Hartle. Alternative interpretations of the decoherent histories framework are also considered. (shrink)

Discussions of habit in Hegel’s thought usually focus on his subjective spirit since this is where the most extended discussion of this issue takes place. This paper argues that habit is also important for understanding Hegel’s Philosophy of Right. The discussion of habit and second nature occur at a critical juncture in the text. This discussion is important for understanding his notion of ethical life and his account of freedom.

There seems to be an interesting difference between judging someone to be good and judging them to be kind. Both judgements are typically positive, but the latter seems to offer more description of the person: we get a slightly more specific sense of what they are like. Very general evaluative concepts are referred to as thin concepts, whilst more specific ones are termed thick concepts. Examples of the former include good, bad, right and wrong, whilst there are countless examples of (...) the latter: brave, rude, gracious, wicked, sympathetic, mean. Marking this distinction opens up some interesting questions. How do the descriptive and evaluative elements of thick concepts combine? Are these elements separable in the first place? Is there a sharp division between thin and thick concepts? Can we mark interesting further distinctions between how thick ethical concepts work and how their aesthetic and epistemic counterparts work? How, if at all, are thick and thin concepts related to reasons and action?.These questions, and others, touch on some of the deepest philosophical issues about the evaluative and normative. They force us to think hard about the place of the evaluative in a (seemingly) nonevaluative world, and they also raise fascinating issues about how language works.This volume of twelve papers explores the phenomenon of thin and thick concepts. They are accompanied by a large introduction that offers an overview of the current and historic field.Authors: Simon Blackburn, Jonathan Dancy, Timothy Chappell, Matti Eklund, Edward Harcourt and Alan Thomas, Simon Kirchin, Debbie Roberts, Michael Smith, Valerie Tiberius, Pekka Väyrynen Eric Wiland, and Nick Zangwill. (shrink)

We review the decoherent histories approach to the interpretation of quantum mechanics. The Everett relative-state theory is reformulated in terms of decoherent histories. A model of evolutionary adaptation is shown to imply decoherence. A general interpretative framework is proposed: probability and value-definiteness are to have a similar status to the attribution of tense in classical spacetime theory.

The descriptions 'good' and 'bad' are examples of thin concepts, as opposed to 'kind' or 'cruel' which are thick concepts. Simon Kirchin provides one of the first full-length studies of the crucial distinction between 'thin' and 'thick' concepts, which is fundamental to many debates in ethics, aesthetics and epistemology.

In Totality and Infinity Levinas presents the 'face to face' as an account of intersubjectivity, but one which maintains the absolute difference of the Other. This essay explores the genesis of the 'face to face' through a discussion of Levinas in relation to Buber. It is argued that Levinas' account of subjectivity shares much in common with Fichte's theory of subjectivity. It is further argued that while the 'face to face' clarifies and opposes traditional problems in social ontology, the 'face (...) to face' is unable to avoid the traditional problems of social ontology that it seeks to avoid. (shrink)

Practical mechanisms for aligning performance, ethics, and accountability are urgently needed. The context for this includes the organisational, technological, and regulatory transformations underlying current patterns of globalisation. These factors, combined with the associated emergence of civil action concerned with corporate accountability and deeper value-shifts, make such realignments a practical possibility.Social and ethical accounting, auditing, and reporting provides one of the few practical mechanisms for companies to integrate new patterns of civil accountability and governance with a business success model focused on (...) deepening stakeholder relationships around core non-financial as well as financial values and interests. (shrink)

The relational approach to tense holds that the now, passage, and becoming are to be understood in terms of relations between events. The debate over the adequacy of this framework is illustrated by a comparative study of the sense in which physical theories, (in)deterministic and (non)relativistic, can lend expression to the metaphysics at issue. The objective is not to settle the matter, but to clarify the nature of this metaphysics and to establish that the same issues are at stake in (...) the relational approach to value-definiteness and probability in quantum mechanics. They concern the existence of a unique present, respectively actuality, and a notion of identity over time that cannot be paraphrased in terms of relations. (shrink)

This book explores issues at the core of modern linguistics and cognitive science. Why are all languages similar in some ways and in others utterly different? Why do languages change and change variably? How did the human capacity for language evolve, and how far did it do so as an innate ability? Simon Kirby looks at these questions from a broad perspective, arguing that they can be studied together. The author begins by examining how far the universal properties of (...) language may be explained by examining the way it is used, and how far by the way it is structured. He then considers what insights may be gained by combining functional and formal approaches. In doing so he develops a way of treating language as an adaptive system, in which its communicative and formal roles are both crucial and complementary. In order to test the effectiveness of competing theories and explanations, Simon Kirby develops computational models to show what universals emerge given a particular theory of language use or acquisition. He presents here both the methodology and the results. Function, Selection, and Innateness is important for its argument, its methodology, and its conclusions. It is a powerful demonstration of the value of looking at language as an adaptive system and goes to the heart of current debates on the evolution and nature of language. (shrink)

What is the meaning of general covariance? We learn something about it from the hole argument, due originally to Einstein. In his search for a theory of gravity, he noted that if the equations of motion are covariant under arbitrary coordinate transformations, then particle coordinates at a given time can be varied arbitrarily - they are underdetermined - even if their values at all earlier times are held fixed. It is the same for the values of fields. The argument can (...) also be made out in terms of transformations acting on the points of the manifold, rather than on the coordinates assigned to the points. So the equations of motion do not fix the particle positions, or the values of fields at manifold points, or particle coordinates, or fields as functions of the coordinates, even when they are specified at all earlier times. It is surely the business of physics to predict these sorts of quantities, given their values at earlier times. The principle of general covariance therefore seems untenable. (shrink)

In thePhilosophy of RightHegel argues that modern life has produced an individualized freedom that conflicts with the communal forms of life constitutive of Greek ethical life. This individualized freedom is fundamentally unsatisfactory, but it is in modernity seemingly resolved into a more adequate form of social freedom in the family, aspects of civil society, and ultimately the state. This article examines whether Hegel’s state can function as a community and by so doing satisfy the need for a substantial ethical life (...) that runs through Hegel’s social thought. The article also examines why Hegel does not provide a detailed analysis of community, as a distinct sphere between the private and the public political sphere in thePhilosophy of Right, and why it is not a key platform of his social freedom. (shrink)

This article investigates the prospects of deliberative democracy through the analysis of small-scale deliberative events, or mini-publics, using empirical methods to understand the process of preference transformation. Evidence from two case studies suggests that deliberation corrects preexisting distortions of public will caused by either active manipulation or passive overemphasis on symbolically potent issues. Deliberation corrected these distortions by reconnecting participants’ expressed preferences to their underlying “will” as well as shaping a shared understanding of the issue.The article concludes by using these (...) insights to suggest ways that mini-public deliberation might be articulated to the broader public sphere so that the benefits might be scaled up. That mini-public deliberation does not so much change individual subjectivity as reconnect it to the expression of will suggests that scaling up the transformative effects should be possible so long as this involves communicating in the form of reasons rather than preferred outcome alone. (shrink)

A ubiquitous assumption about composite material objects is that—if they exist at all—they are single things. This chapter articulates and defends manyism, which rejects that assumption. According to manyism, each composite object is simply its many parts. Since manyism accepts the existence of composite objects, it is distinct from nihilism; since manyism denies that composite objects are each one in number in addition to being many in number, it is distinct from the view known as composition as identity (CAI). What’s (...) more, manyism is both coherent and attractive. Manyism is coherent because it can be underwritten by a defensible quasi-Quinean metaontology, and because it’s not analytic that objects are each one in number. Manyism is attractive because it shares all of the benefits of CAI without having to join CAI in objectionably positing many–one identities, and without incurring other serious costs. (shrink)

The problem of measurement is usually thought of as a problem of physics. Certainly the straightforward solutions modify or supplement the basic equations. One might instead conclude that theories are only instruments for coördinating observable phenomena, and perhaps that is what Bohr’s Copenhagen interpretation really comes down to. For most of us this sort of “philosophical” resolution of the problem of measurement is not acceptable.

This article examines Derrida's critique of Hegel. It argues that there are two key issues that Derrida misunderstands in Hegel's thought: first, Hegel's response to the concept-intuition dichotomy that plagued Kant's critical thought; second, that Hegel's notions of reason and the dialectic, when they are conceived non-metaphysically, are not tools employed to subsume differences but are, like Derrida's différance , fundamentally concerned with thought's instability. The article shows the way in which Derrida develops the notion of singularity by an examination (...) of the discussion of responsibility in his later writings. It is argued that the way that Hegel and Derrida consider the notion of singularity is a much better marker for distinguishing these two thinkers than Derrida's own interpretation of Hegel. Key Words: Jacques Derrida • dialectic • differance • G. W. F. Hegel • normativity • reason • responsibility • singularity. (shrink)

This volume has its roots in two recent developments within mainstream analytic epistemology: a growing recognition over the past two or three decades of the active and social nature of our epistemic lives; and, more recently still, the increasing appreciation of the various ways in which the epistemic practices of individuals and societies can, and often do, go wrong. The theoretical analysis of these breakdowns in epistemic practice, along with the various harms and wrongs that follow as a consequence, constitutes (...) an approach to epistemology that we refer to as non-ideal epistemology. In this introductory chapter we introduce and contextualise the ten essays that comprise this volume, situating them within four broad sub-fields: vice epistemology, epistemic injustice, inter-personal epistemic practices, and applied epistemology. We also provide a brief overview of several other important growth areas in non-ideal epistemology. (shrink)

Over the past few years the use of stimulants such as methylphenidate and modafinil among the student population has attracted considerable debate in the pages of bioethics journals. Under the rubric of cognitive enhancement, bioethicists have discussed this use of stimulants—along with future technologies of enhancement—and have launched a sometimes forceful debate of such practices. In the following paper, it is argued that even if we focus solely upon current practices, the term cognitive enhancement encompasses a wide range of ethical (...) considerations that can usefully be addressed without the need for speculation. In taking this position it is suggested that we divide cognitive enhancement into a series of empirically-constructed frameworks—medical risks and benefits, self-medication and under-prescription, prescription drug abuse and over-medication, and finally, the intention to cognitively enhance. These are not mutually exclusive frameworks, but provide a way in which to identify the scope of the issue at hand and particular ethical and medical questions that may be relevant to enhancement. By a process of elimination it is suggested that we can indeed talk of cognitive enhancement as an observable set of practices. However, in doing so we should be aware of how academic commentaries and discussion may be seen as both capturing reality and reifying cognitive enhancement as an entity. (shrink)

What is the relation between what we ought to do, on the one hand, and our epistemic access to the ought-giving facts, on the other? In assessing this,it is common to distinguish ‘objective’ from ‘subjective’ oughts. Very roughly, on the objectivist conception what an agent ought to do is determined by ought-giving facts in such a way that does not depend on the agent’s beliefs about, or epistemic access to, those facts; whereas on the subjectivist conception, what an agent ought (...) to do depends on his beliefs. This paper defends the need for, and explicates, a third category of ‘ought’: ‘warranted oughts’. Section 1 introduces the distinction between objective and subjective ‘oughts’. Sections 2–3 draw attention to some serious problems with each. Section 4 examines, though rejects, a recent attempt to replace subjective ‘oughts’ with objective ‘wide-scope oughts’ operating on belief-action combinations. Section 5 explicates the notion of a warranted ‘ought’ and defends the account against some possible objections. The resulting a picture is one in which an adequate analysis of practical normativity requires both objective and warranted ‘oughts’. Section 6 concludes by responding to a worry about countenancing both. (shrink)

After briefly describing the history and significance of the nature–reason dualism for philosophy this article examines why much of the Kantian inspired examination of norms and ethics continues to appeal to this division. It is argued that much of what is claimed to be rationally legitimated norms can, at least in part, be understood as binding on actions and beliefs, not because they are rationally legitimated, but because they are habituated. Drawing on Hegel’s discussion of ethical life and habit it (...) is argued that human subjects identify most practices and norms as their own through self-feeling, not reason. It is on this basis that norms are taken not just as the basis for action but are constitutive of human identity, an identity that is spiritual, embodied and affective. While habit is central to the way Hegel reconfigures ethics and norms, as well as the distinct model of freedom that he develops in his social and political thought, it will be argued that habit has its limits as a model for human freedom, limits of which Hegel is well aware. (shrink)

I here defend microphysical manyism. According to microphysical manyism, each composite or higher-level object is a mere plurality of microphysical particles. After clarifying the commitments of the view, I offer two physicalist-friendly arguments in its favour. The first argument appeals to the Canberra Plan. Here I argue that microphysical particles acting in unison play the theoretical roles associated with composite objects - that they do everything that we think of composite objects as doing - and thus that composite objects are (...) to be identified with pluralities of microphysical particles. Along the way I rebut the objections that pluralities of particles don’t display the right emergent, ‘lingering’, or modal properties to be good candidates for identification with higher-level objects. In the second argument I claim that microphysical manyism is uniquely able to capture a compelling and widespread physicalist intuition concerning the intimate nature of the relationship between higher-level, composite objects and the microphysical world. (shrink)

Psychological literature indicates that actions performed with the assistance of cognition‐enhancing biomedical technologies are often deemed to be less praiseworthy than similar actions performed without such assistance. This study examines (i) whether this result extends to the bioenhancement of moral capacities, and (ii) if so, what explains the effect of moral bioenhancement on perceived praiseworthiness. The findings indicate that actions facilitated by morally bioenhanced individuals are considered less deserving of praise than similar actions facilitated by ‘traditional’ moral enhancement—for example, moral (...) self‐education. This diminished praise does not seem to be driven by an aversion to (moral) bioenhancement per se. Instead, it appears to be primarily attributable to a perceived lack of effort exerted by bioenhanced individuals in the course of their moral enhancement. Our findings advance the philosophical discourse on the foundations of praise in the context of moral bioenhancement by elucidating the empirical basis underlying some assumptions commonly employed to argue for or against the permissibility of moral bioenhancement. (shrink)

There is a libertarian argument for live donor organ markets, according to which live donor organ markets would be permitted if we simply refrained from imposing any substantive and controversial moral assumptions on people who reasonably disagree about morality and justice. I argue that, to the contrary, this endorsement of live donor organ markets depends upon the libertarians’ adoption of a substantive and deeply controversial conception of strong, extensive property rights. This is shown by the fact that these rights would (...) prevent states intervening in cases of preventable and intuitively impermissible wronging of others that can arise when free individuals engage in voluntary offers and exchanges. I outline two forms of such wronging: discrimination and disrespectful demands. I argue that although these types of acts are morally impermissible, the policy question of whether and how they should be regulated by states is non-trivial. I then argue that there is good reason to think that organ markets would rely on disrespectful demands. This may help explain the widespread moral repugnance people feel toward organ trading. It also provides a prima facie, though not decisive, case for states to prohibit such markets. (shrink)

A key question of the ‘maverick’ tradition of the philosophy of mathematical practice is addressed, namely what is mathematical progress. The investigation is based on an article by Penelope Maddy devoted to this topic in which she considers only contributions ‘of some mathematical importance’ as progress. With the help of a case study from contemporary mathematics, more precisely from tropical geometry, a few issues with her proposal are identified. Taking these issues into consideration, an alternative account of ‘mathematical importance’, broadly (...) within the framework of progress Maddy offers, is developed with a special focus on mathematicians’ peer-review practice. (shrink)

Debates over the significance of the particle concept, and the problem of locality-how do we represent localized phenomena?-appear to presuppose that particles and observed phenomena are things rather than events. Well-known theorems (Hergerfelt, Reeh-Schlieder), and a recent variant of Hergerfelt's theorem due to David Malement, present a problem of locality only given the tacit appeal to the concept of thing, in fact an individual, in a sense contrary to particle indistinguishability. There is no difficulty with the particle concept per se, (...) but it is a global construction more than one step removed from events actually observed, which are represented by local integrals over self-adjoint field densities. (shrink)

Empirical research on human–robot interaction has demonstrated how humans tend to react to social robots with empathic responses and moral behavior. How should we ethically evaluate such responses to robots? Are people wrong to treat non-sentient artefacts as moral patients since this rests on anthropomorphism and ‘over-identification’ —or correct since spontaneous moral intuition and behavior toward nonhumans is indicative for moral patienthood, such that social robots become our ‘Others’?. In this research paper, I weave extant HRI studies that demonstrate empathic (...) responses toward robots with the recent debate on moral status for robots, on which the ethical evaluation of moral behavior toward them is dependent. Patienthood for robots has standardly been thought to obtain on some intrinsic ground, such as being sentient, conscious, or having interest. But since these attempts neglect moral experience and are curbed by epistemic difficulties, I take inspiration from Coeckelbergh and Gunkel’s ‘relational approach’ to explore an alternative way of accounting for robot patienthood based on extrinsic premises. Based on the ethics of Danish theologian K. E. Løgstrup I argue that empathic responses can be interpreted as sovereign expressions of life and that these expressions benefit human subjects—even if they emerge from social interaction afforded by robots we have anthropomorphized. I ultimately develop an argument in defense of treating robots as moral patients. (shrink)

The reanalysis of genomic sequencing results has the potential to provide results that are of considerable medical and personal importance to recipients. Employing interviews with forty-seven predominantly medically underserved families and ethnographic observations we argue that there is pressing need to standardize the approach taken to reanalysis. Our findings highlight that study participants were unclear as to the likelihood of reanalysis happening, the process of initiating reanalysis, and whether they would receive revised results. Their reflections mirror the lack a specific (...) focus upon reanalysis within consent and results sessions as observed in clinical settings. Mechanisms need to be put into place that standardize the approach to reanalysis in research and in clinical contexts. This would enable clinicians and genetic counsellors to communicate clearly with research participants with respect to potential for reanalysis of results and the process of reanalysis. We argue that that the role of reanalysis is too important to be referred to in an ad-hoc manner. Furthermore, the ad-hoc nature of the current process may increase health inequities given the likelihood that only those families who have the means to press for reanalysis are likely to receive it. (shrink)

In recent times it has become common to encounter philosophers who recommend the replacement of one principle concerning theory choice, Ockham’s Razor, with another: the Laser. Whilst the Razor tells us not to multiply entities beyond necessity, the Laser tells us only to avoid multiplying fundamental entities beyond necessity. There appear to be seven arguments in the literature for the Laser. They divide into three categories: arguments from the nature of non-fundamentality attempt to motivate the Laser by appeal to various (...) observations about what it is to be non-fundamental; arguments from cases describe hypothetical or actual cases, and allege that only the Laser accords with our intuitive judgements about them; and arguments from analogy claim that ontological parsimony is analogous to conceptual economy, and that this analogy recommends the Laser. I provide novel responses to each of the extant arguments for the Laser, and conclude that there is currently no good reason for replacing the Razor with the Laser. (shrink)

Ethical decision-making is inherent to the research ethics committee deliberation process. While ethical codes, regulations, and research standards are indispensable in guiding this process,...

Physicians make some medical decisions without disclosure to their patients. Nondisclosure is possible because these are silent decisions to refrain from screening, diagnostic or therapeutic interventions. Nondisclosure is ethically permissible when the usual presumption that the patient should be involved in decisions is defeated by considerations of clinical utility or patient emotional and physical well-being. Some silent decisions - not all - are ethically justified by this standard. Justified silent decisions are typically dependent on the physician's professional judgment, experience and (...) knowledge, and are not likely to be changed by patient preferences. We condemn the inappropriate exclusion of the patient from the decision-making process. However, if a test or treatment is unlikely to yield a net benefit, disclosure and discussion are at times unnecessary. Appropriate silent decisions are ethically justified by such considerations as patient benefit or economy of time. (shrink)

There is a simple story to be told about Derridarsquo;s relation to Hegel. He develops his core concepts such as diffeacute;rance and trace through an essentially negative relation to the central notions of the idealist tradition. Derrida has been particularly concerned to undermine what he takes to be the heart of the idealist projectmdash;the self-present subject. This paper examines the influence of Heidegger on the deconstructive critique of idealist subjectivity and presents Derridarsquo;s alternative to the metaphysical subject. It argues that (...) his critique of idealist subjectivity does not accord with Hegelrsquo;s presentation of subjectivity when one conceives that project as a response to problems in the view of subjectivity developed by Fichte and Kant. br /. (shrink)

A relationist will account for the use of ‘left’ and ‘right’ in terms of relative orientations, and other properties and relations invariant under mirroring. This analysis will apply whenever mirroring is a symmetry, so it certainly applies to classical mechanics; we argue it applies to any physical theory formulated on a manifold: it is in this sense an a priori symmetry. It should apply in particular to parity violating theories in quantum mechanics; mirror symmetry is only broken in such theories (...) as a special symmetry. (shrink)

SummaryThe celebrated Swedish natural philosopher and visionary theologian Emanuel Swedenborg (1688–1772) devoted major efforts to the establishment of a reliable method for the determination of longitude at sea. He first formulated a method, based on the astronomical observation of lunar position, while in London in 1710–12. He issued various versions of the method, both in Latin and in Swedish, throughout his career. In 1766, at the age of 78, he presented his scheme for judgment by the Board of Longitude in (...) London. The rich archive of Swedenborg's career allows an unusually detailed historical analysis of his longitude project, an analysis rather better documented than that available for the host of contemporary projectors who launched longitude schemes, submitted their proposals to the Board of Longitude, and have too often been ignored or dismissed by historians. This analysis uses the longitude work to illuminate key aspects of Swedenborg's wider enterprises, including his scheme to set up an astronomical observatory in southern Sweden to be devoted to lunar and stellar observation, his complex attitude to astronomical and magnetic cosmology, and his attempt to fit the notion of longitude into his visionary world-view. Swedenborg's programme also helps make better sense of the metropolitan and international networks of diplomatic and natural philosophical communication in which the longitude schemes were developed and judged. It emerges that his longitude method owed much to the established principles of earlier Baroque and Jesuit natural philosophy while his mature cosmology sought a rational and enlightened model of the universe. (shrink)

This study analyses the sensitivity of public goods contributions through the lens of psychological motives. We report the results of a public goods experiment in which subjects were induced with the motives of care and anger through autobiographical recall. Subjects’ preferences, beliefs, and perceptions under each motive are compared with those of subjects experiencing a neutral autobiographical recall control condition. We find, but only for those subjects with the highest comprehension of the game, that care elicits significantly higher contributions than (...) anger, with the control treatment in between. This positive influence of the care motive on unconditional giving is accounted for partly by preferences for giving and partly by beliefs concerning greater contributions by others. Anger also affects attention to own and other’s payoffs and perceptions of the game’s incentive structure. (shrink)