Data are lacking with regard to participants' perspectives on return of genetic research results to relatives, including after the participant's death. This paper reports descriptive results from 3,630 survey respondents: 464 participants in a pancreatic cancer biobank, 1,439 family registry participants, and 1,727 healthy individuals. Our findings indicate that most participants would feel obligated to share their results with blood relatives while alive and would want results to be shared with relatives after their death.

Background: Genomic analysis may reveal both primary and secondary findings with direct relevance to the health of probands’ biological relatives. Researchers question their obligations to return findings not only to participants but also to family members. Given the social value of privacy protection, should researchers offer a proband’s results to family members, including after the proband’s death? Methods: Preferences were elicited using interviews and a survey. Respondents included probands from two pancreatic cancer research resources, plus biological and nonbiological family members. (...) Hypothetical scenarios based on actual research findings from the two cancer research resources were presented; participants were asked return of results preferences and justifications. Interview transcripts were coded and analyzed; survey data were analyzed descriptively. Results: Fifty-one individuals (17 probands, 21 biological relatives, 13 spouses/partners) were interviewed. Subsequently, a mailed survey was returned by 464 probands, 1,040 biological family members, and 399 spouses/partners. This analysis highlights the interviews, augmented by survey findings. Probands and family members attribute great predictive power and lifesaving potential to genomic information. A majority hold that a proband’s genomic results relevant to family members’ health ought to be offered. While informants endorse each individual’s choice whether to learn results, most express a strong moral responsibility to know and to share, particularly with the younger generation. Most have few concerns about sharing genetic information within the family; rather, their concerns focus on the health consequences of not sharing. Conclusions: Although additional studies in diverse populations are needed, policies governing return of genomic results should consider how families understand genomic data, how they value confidentiality within the family, and whether they endorse an ethics of sharing. A focus on respect for individual privacy—without attention to how the broad social and cultural context shapes preferences within families—cannot be the sole foundation of policy. (shrink)

Genomic research results and incidental findings with health implications for a research participant are of potential interest not only to the participant, but also to the participant's family. Yet investigators lack guidance on return of results to relatives, including after the participant's death. In this paper, a national working group offers consensus analysis and recommendations, including an ethical framework to guide investigators in managing this challenging issue, before and after the participant's death.

Returning genomic research results to family members raises complex questions. Genomic research on life-limiting conditions such as cancer, and research involving storage and reanalysis of data and specimens long into the future, makes these questions pressing. This author group, funded by an NIH grant, published consensus recommendations presenting a framework. This follow-up paper offers concrete guidance and tools for implementation. The group collected and analyzed relevant documents and guidance, including tools from the Clinical Sequencing Exploratory Research Consortium. The authors then (...) negotiated a consensus toolkit of processes and documents. That toolkit offers sample consent and notification documents plus decision flow-charts to address return of results to family of living and deceased participants, in adult and pediatric research. Core concerns are eliciting participant preferences on sharing results with family and on choice of a representative to make decisions about sharing after participant death. (shrink)

As we look to the future in a world with porous borders and boundaries transgressed by technologies, an inevitable question is:Can there be a single, global bioethics? Intimately intertwined with this question is a second one: How might a global bioethics account for profound - and constantly transforming - sources of cultural difference? Can a uniform, global bioethics be relevant cross-culturally? These are not simple questions, rather, a multi-dimensional answer is required. It is important to distinguish between two meanings of (...) bioethics: the academic discipline of bioethics as opposed to bioethics as a set of practices governing clinical care and scientific research. There is growing evidence to support the notion of a shared global understanding of bioethics as a field of inquiry focused on the moral dimensions of science and biomedicine. (shrink)

As we look to the future in a world with porous borders and boundaries transgressed by technologies, an inevitable question is:Can there be a single, global bioethics? Intimately intertwined with this question is a second one: How might a global bioethics account for profound - and constantly transforming - sources of cultural difference? Can a uniform, global bioethics be relevant cross-culturally? These are not simple questions, rather, a multi-dimensional answer is required. It is important to distinguish between two meanings of (...) bioethics: the academic discipline of bioethics as opposed to bioethics as a set of practices governing clinical care and scientific research. There is growing evidence to support the notion of a shared global understanding of bioethics as a field of inquiry focused on the moral dimensions of science and biomedicine. (shrink)

Frames, i.e., recursive attribute-value structures, are a general format for the decomposition of lexical concepts. Attributes assign unique values to objects and thus describe functional relations. Concepts can be classified into four groups: sortal, individual, relational and functional concepts. The classification is reflected by different grammatical roles of the corresponding nouns. The paper aims at a cognitively adequate decomposition, particularly, of sortal concepts by means of frames. Using typed feature structures, an explicit formalism for the characterization of cognitive frames is (...) developed. The frame model can be extended to account for typicality effects. Applying the paradigm of object-related neural synchronization, furthermore, a biologically motivated model for the cortical implementation of frames is developed. Cortically distributed synchronization patterns may be regarded as the fingerprints of concepts. (shrink)

Zusammenfassung Wie kann Gottes Gegenwart trotz ihrer Verborgenheit wahrgenommen werden? In dem folgenden Beitrag möchte ich zeigen, wie Simone Weil die Erfahrungen der Verborgenheit und der Abwesenheit Gottes als Signatur des Unglücks und der Entwurzelung der Menschen in der Moderne analysiert. Des Weiteren wird dargestellt, wie Simone Weil vor diesem Hintergrund mit einer kreuzestheologischen Denkfigur reflektiert, wie die Gottesliebe in besonderer Weise im Unglück verborgen anwesend sein kann, trotz Erfahrung der Abwesenheit Gottes. Hier schließt sich die erkenntnistheoretische Frage nach der (...) Wahrnehmbarkeit der verborgenen Gegenwart Gottes an. So soll ausgeführt werden, wie Simone Weil aufzeigt, wie durch ästhetische Formen der Schönheit und Ordnung der Welt, durch ethische Formen von Nächstenliebe und Freundschaft und durch die religiöse Formen in Liturgie und Gebet als höchster Form der Aufmerksamkeit die verborgen gegenwärtige Gottesliebe indirekt wahrgenommen werden kann. Dies spricht schließlich für eine andere Deutung der Verborgenheit Gottes als im sog. Verborgenheitsargument von J. L. Schellenberg, mit dem von der Verborgenheit auf die Nichtexistenz Gottes geschlossen wird. (shrink)

Body checking, characterized by the repeated visual or physical inspection of particular parts of one’s own body (e.g. thighs, waist, or upper arms) is one of the most prominent behaviors associated with eating disorders, particularly Anorexia Nervosa (AN). In this paper, we explore the explanatory potential of the Recalcitrant Fear Model of AN (RFM) in relation to body checking. We argue that RFM, when combined with certain plausible auxiliary hypotheses about the cognitive and epistemic roles of emotions, is able to (...) explain key characteristics of body checking, including how body checking behavior becomes habitual and compulsive. (shrink)

In a recent paper in this journal, Carter and Peterson raise two distinctly epistemological puzzles that arise for anyone aspiring to defend the precautionary principle. The first puzzle trades on an application of epistemic contextualism to the precautionary principle; the second puzzle concerns the compatibility of the precautionary principle with the de minimis rule. In this note, I argue that neither puzzle should worry defenders of the precautionary principle. The first puzzle can be shown to be an instance of the (...) familiar but conceptually harmless challenge of adjudicating between relevant interests to reach assessments of threats when applying the precautionary principle. The second puzzle can be shown to rely on a subtle but crucial misrepresentation of the relevant probabilities at play when applying the precautionary principle. (shrink)

Standard epistemology takes it for granted that there is a special kind of value: epistemic value. This claim does not seem to sit well with act utilitarianism, however, since it holds that only welfare is of real value. I first develop a particularly utilitarian sense of “epistemic value”, according to which it is closely analogous to the nature of financial value. I then demonstrate the promise this approach has for two current puzzles in the intersection of epistemology and value theory: (...) first, the problem of why knowledge is better than mere true belief, and second, the relation between epistemic justification and responsibility. (shrink)

As with any proposal for institutional reform, and especially one that has gained so much ground in such a short amount of time, this paper asks whether diversity, equity, and inclusion (DEI) movement is good for corporations. Are businesses stronger with DEI practices and ideas or weaker? We believe that the DEI movement is asking the right questions: How do we create more just and equitable institutions? The challenge, however, is whether this movement is giving the right answers to such (...) questions. The main premise of our paper is that without deeper principles than DEI itself, these qualities of corporate life will be misunderstood, misused, and disordered in our increasingly fragmented and politicized culture. We propose in this essay that “subsidiarity” serves as one of those deeper principles that can order and enrich our understanding of DEI. It serves as a gift principle that begins to reveal the deepest nature of our work, namely, that our work allows us to exercise our gifts in serving others. (shrink)

For at least three decades, philosophers have argued that general causation and causal explanation are contrastive in nature. When we seek a causal explanation of some particular event, we are usually interested in knowing why that event happened rather than some other specified event. And general causal claims, which state that certain event types cause certain other event types, seem to make sense only if appropriate contrasts to the types of events acting as cause and effect are specified. In recent (...) years, philosophers have extended the contrastive theory of causation to encompass singular causation as well. In this article, I argue that this extension of the theory was a mistake. Although general causation and causal explanation may well be contrastive in nature, singular causation is not. (shrink)

Inquiry is an aim-directed activity, and as such governed by instrumental normativity. If you have reason to figure out a question, you have reason to take means to figuring it out. Beliefs are governed by epistemic normativity. On a certain pervasive understanding, this means that you are permitted – maybe required – to believe what you have sufficient evidence for. The norms of inquiry and epistemic norms both govern us as agents in pursuit of knowledge and understanding, and, on the (...) surface, they do so in harmony. Recently, however, Jane Friedman (2020) has pointed out that they are in tension with each other. In this paper, I aim to resolve this tension by showing that reasons for acts of inquiry – zetetic reasons – and epistemic reasons for belief can both be understood as flowing from the same general normative principle: the transmission principle for instrumental reasons. The resulting account is a version of epistemic instrumentalism that offers an attractive unity between zetetic and epistemic normativity. (shrink)

Evidence on AI acceptance comes from a diverse field comprising public opinion research and largely experimental studies from various disciplines. Differing theoretical approaches in this research, however, imply heterogeneous ways of studying AI acceptance. The present paper provides a framework for systematizing different uses. It identifies three families of theoretical perspectives informing research on AI acceptance—user acceptance, delegation acceptance, and societal adoption acceptance. These models differ in scope, each has elements specific to them, and the connotation of technology acceptance thus (...) changes when shifting perspective. The discussion points to a need for combining the three perspectives as they have all become relevant for AI. A combined approach serves to systematically relate findings from different studies. And as AI systems affect people in different constellations and no single perspective can accommodate them all, building blocks from several perspectives are needed to comprehensively study how AI is perceived in society. (shrink)

Within the growing developmental literature on children's testimonial learning, the emphasis placed on children's evaluations of testimonial evidence has shielded from view some of the more collaborative dimensions of testimonial learning. Drawing on recent philosophical work on testimony and interpersonal trust, we argue for an alternative way of conceptualizing the social nature of testimonial learning. On this alternative, some testimonial learning is the result of a jointly collaborative epistemic activity, an activity that aims at the epistemic goal of true belief, (...) but that does so by means of an irreducibly social process. (shrink)

Das Buch weist in exemplarischen Fallstudien von der Antike bis zur Gegenwart die zentrale Rolle von Bildern für Prozesse der Vergemeinschaftung auf. Gegen Ende des 20. Jahrhunderts setzt in der akademischen Diskussion eine verstärkte Rückwendung zum Konzept der Gemeinschaft ein.

In this paper I propose a teleological account of epistemic reasons. In recent years, the main challenge for any such account has been to explicate a sense in which epistemic reasons depend on the value of epistemic properties. I argue that while epistemic reasons do not directly depend on the value of epistemic properties, they depend on a different class of reasons which are value based in a direct sense, namely reasons to form beliefs about certain propositions or subject matters. (...) In short, S has an epistemic reason to believe that p if and only if S is such that if S has reason to form a belief about p, then S ought to believe that p. I then propose a teleological explanation of this relationship. It is also shown how the proposal can avoid various subsidiary objections commonly thought to riddle the teleological account. (shrink)

The theory of belief, according to which believing that p essentially involves having as an aim or purpose to believe that p truly, has recently been criticised on the grounds that the putative aim of belief does not interact with the wider aims of believers in the ways we should expect of genuine aims. I argue that this objection to the aim theory fails. When we consider a wider range of deliberative contexts concerning beliefs, it becomes obvious that the aim (...) of belief can interact with and be weighed against the wider aims of agents in the ways required for it to be a genuine aim. (shrink)

Does transparency in doxastic deliberation entail a constitutive norm of correctness governing belief, as Shah and Velleman argue? No, because this presupposes an implausibly strong relation between normative judgements and motivation from such judgements, ignores our interest in truth, and cannot explain why we pay different attention to how much justification we have for our beliefs in different contexts. An alternative account of transparency is available: transparency can be explained by the aim one necessarily adopts in deliberating about whether to (...) believe that p. To show this, I reconsider the role of the concept of belief in doxastic deliberation, and I defuse 'the teleologian's dilemma'. (shrink)

According to the thesis of pragmatic encroachment, practical circumstances can affect whether someone is in a position to know or rationally believe a proposition. For example, whether it is epistemically rational for a person to believe that the bank will be open on Saturdays, can depend not only on the strength of the person’s evidence, but also on how practically important it is for the person not to be wrong about the bank being open on Saturdays. In recent years, philosophers (...) have argued that moral considerations can also affect the epistemic rationality of belief, thus giving rise to moral encroachment. In previous work (Steglich-Petersen, forthcoming a), I have developed an explanation of pragmatic encroachment grounded in an instrumentalist theory of epistemic reasons. Here, I argue that this explanation extends to moral encroachment as well, including so-called “radical” moral encroachment. I also show how this explanation dispels the worry raised by Gerken (2019), that pragmatic encroachment might give rise to morally adverse consequences in the form of epistemic injustice. (shrink)

Epistemic instrumentalists seek to understand the normativity of epistemic norms on the model practical instrumental norms governing the relation between aims and means. Non-instrumentalists often object that this commits instrumentalists to implausible epistemic assessments. I argue that this objection presupposes an implausibly strong interpretation of epistemic norms. Once we realize that epistemic norms should be understood in terms of permissibility rather than obligation, and that evidence only occasionally provide normative reasons for belief, an instrumentalist account becomes available that delivers the (...) correct epistemic verdicts. On this account, epistemic permissibility can be understood on the model of the wide-scope instrumental norm for instrumental rationality, while normative evidential reasons for belief can be understood in terms of instrumental transmission. (shrink)

A popular account of epistemic justification holds that justification, in essence, aims at truth. An influential objection against this account points out that it is committed to holding that only true beliefs could be justified, which most epistemologists regard as sufficient reason to reject the account. In this paper I defend the view that epistemic justification aims at truth, not by denying that it is committed to epistemic justification being factive, but by showing that, when we focus on the relevant (...) sense of ‘justification’, it isn’t in fact possible for a belief to be at once justified and false. To this end, I consider and reject three popular intuitions speaking in favor of the possibility of justified false beliefs, and show that a factive account of epistemic justification is less detrimental to our normal belief forming practices than often supposed. (shrink)

The alien invasive Red King Crab in the Barents Sea represents both a threat, via ecosystem impacts, and a gain as a revenue source from food sales. Uncertainties exist regarding the ecological impacts but debate in Norway has also emphasised the economic benefits to marginalised fisher communities. This paper reports on a Q-methodology study involving key stakeholders to probe the extent to which divisions exist between different groups. While divisions are indeed found and two groupings identified, these are not as (...) clear as suggested by the lines typically portrayed in the media and elsewhere -, i.e. economic gains versus ecological preservation. Stakeholder groups reported here generally agreed that biodiversity concerns should be central and that further invasion was undesirable due to potential impacts on ecosystem services. (shrink)

A popular account of luck, with a firm basis in common sense, holds that a necessary condition for an event to be lucky, is that it was suitably improbable. It has recently been proposed that this improbability condition is best understood in epistemic terms. Two different versions of this proposal have been advanced. According to my own proposal :361–377, 2010), whether an event is lucky for some agent depends on whether the agent was in a position to know that the (...) event would occur. And according to Stoutenburg :319–334, 2015, Synthese, 1–15, 2018), whether an event is lucky for an agent depends on whether the event was guaranteed or certain to occur in light of the agent’s evidence. In this paper, I argue that we should prefer the account in terms of knowledge over that in terms of evidential certainty. (shrink)

The idea that humans should abandon their individuality and use technology to bind themselves together into hivemind societies seems both farfetched and frightening – something that is redolent of the worst dystopias from science fiction. In this article, we argue that these common reactions to the ideal of a hivemind society are mistaken. The idea that humans could form hiveminds is sufficiently plausible for its axiological consequences to be taken seriously. Furthermore, far from being a dystopian nightmare, the hivemind society (...) could be desirable and could enable a form of sentient flourishing. Consequently, we should not be so quick to deny it. We provide two arguments in support of this claim – the axiological openness argument and the desirability argument – and then defend it against three major objections. (shrink)

Certain instances of contraction are provable in Zardini’s system $\mathbf {IK}^\omega $ which causes triviality once a truth predicate and suitable fixed points are available.

When one has both epistemic and practical reasons for or against some belief, how do these reasons combine into an all-things-considered reason for or against that belief? The question might seem to presuppose the existence of practical reasons for belief. But we can rid the question of this presupposition. Once we do, a highly general ‘Combinatorial Problem’ emerges. The problem has been thought to be intractable due to certain differences in the combinatorial properties of epistemic and practical reasons. Here we (...) bring good news: if we accept an independently motivated version of epistemic instrumentalism—the view that epistemic reasons are a species of instrumental reasons—we can reduce The Combinatorial Problem to the relatively benign problem of how to weigh different instrumental reasons against each other. As an added benefit, the instrumentalist account can explain the apparent intractability of The Combinatorial Problem in terms of a common tendency to think and talk about epistemic reasons in an elliptical manner. (shrink)

Nishi Shah has recently argued that transparency in doxastic deliberation supports a strict version of evidentialism about epistemic reasons. I argue that Shah's argument relies on a principle that is incompatible with the strict version of evidentialism Shah wishes to advocate.

Many have found it plausible that practical circumstances can affect whether someone is in a position to know or rationally believe a proposition. For example, whether it is rational for a person to believe that the bank will be open tomorrow, can depend not only on the person’s evidence, but also on how practically important it is for the person not to be wrong about the bank being open tomorrow. This supposed phenomenon is known as “pragmatic encroachment” on knowledge and (...) rational belief. Assuming that the phenomenon is real, I ask what explains it. I argue that a variant of instrumentalism about epistemic reasons offers a natural explanation, that at the same time is able avoid commitment to a more radical form of pragmatism. (shrink)

The predominant view in developmental psychology is that young children are able to reason with the concept of desire prior to being able to reason with the concept of belief. We propose an explanation of this phenomenon that focuses on the cognitive tasks that competence with the belief and desire concepts enable young children to perform. We show that cognitive tasks that are typically considered fundamental to our competence with the belief and desire concepts can be performed with the concept (...) of desire in the absence of competence with the concept of belief, whereas the reverse is considerably less feasible. (shrink)

It is widely agreed that obsessive-compulsive disorder involves irrationality. But where in the complex of states and processes that constitutes OCD should this irrationality be located? A pervasive assumption in both the psychiatric and philosophical literature is that the seat of irrationality is located in the obsessive thoughts characteristic of OCD. Building on a puzzle about insight into OCD (Taylor 2022), we challenge this pervasive assumption, and argue instead that the irrationality of OCD is located in the emotions that are (...) characteristic of OCD, such as anxiety or fear. In particular, we propose to understand the irrationality of OCD as a matter of harboring recalcitrant emotions. We argue that this account not only solves the puzzle about insight, but also makes better sense of how OCD sufferers experience and describe their condition and helps explain some otherwise puzzling features of compulsive behavior. (shrink)

In a recent article, I criticized Kathrin Glüer and Åsa Wikforss's so-called “no guidance argument” against the truth norm for belief, for conflating the conditions under which that norm recommends belief with the psychological state one must be in to apply the norm. In response, Glüer and Wikforss have offered a new formulation of the no guidance argument, which makes it apparent that no such conflation is made. However, their new formulation of the argument presupposes a much too narrow understanding (...) of what it takes for a norm to influence behaviour, and betrays a fundamental misunderstanding of the point of the truth norm. Once this is taken into account, it becomes clear that the no guidance argument fails. (shrink)

In this article several justifications of what I call ‘the claim from adoption’ are examined. The claim from adoption is that, instead of expending resources on bringing new children into the world using reproductive technology and then caring for these children, we ought to devote these resources to the adoption and care of existing destitute children. Arguments trading on the idea that resources should be directed to adoption instead of assisted reproduction because already existing people can benefit from such a (...) use of resources whereas we cannot benefit individuals by bringing them into existence are rejected. It is then argued that a utilitarian argument proposed by Christian Munthe that supports the claim from adoption in some situations should be rejected because the support it offers does not extend to certain situations in which it seems morally obvious that resources should be expended on adoption rather than assisted reproduction. A version of the Priority View improves upon Munthe’s utilitarianism by supporting the claim from adoption in the cases in which Munthe’s argument failed. Some allegedly counterintuitive implications of the Priority View are then discussed, and it is concluded that the Priority View is more plausible than utilitarianism. n a concluding section on policy issues it is argued that, even though the claim from adoption can be justified in a variety of situations, it does not follow that, in these situations, governments should direct resources away from assisted reproduction and towards adoption. (shrink)

Cosmopolitics, the concept of a world politics based on shared democratic values, is in an increasingly fragile state.

It seems obvious that when higher-order evidence makes it rational for one to doubt that one’s own belief on some matter is rational, this can undermine the rationality of that belief. This is known as higher-order defeat. However, despite its intuitive plausibility, it has proved puzzling how higher-order defeat works, exactly. To highlight two prominent sources of puzzlement, higher-order defeat seems to defy being understood in terms of conditionalization; and higher-order defeat can sometimes place agents in what seem like epistemic (...) dilemmas. This chapter draws attention to an overlooked aspect of higher-order defeat, namely that it can undermine the resilience of one’s beliefs. The notion of resilience was originally devised to understand how one should reflect the ‘weight’ of one’s evidence. But it can also be applied to understand how one should reflect one’s higher-order evidence. The idea is particularly useful for understanding cases where one’s higher-order evidence indicates that one has failed in correctly assessing the evidence, without indicating whether one has over- or underestimated the degree of evidential support for a proposition. But it is exactly in such cases that the puzzles of higher-order defeat seem most compelling. (shrink)

In his influential discussion of the aim of belief, David Owens argues that any talk of such an ‘aim’ is at best metaphorical. In order for the ‘aim’ of belief to be a genuine aim, it must be weighable with other aims in deliberation, but Owens claims that this is impossible. In previous work, I have pointed out that if we look at a broader range of deliberative contexts involving belief, it becomes clear that the putative aim of belief is (...) capable of being weighed against other aims. Recently, however, Ema Sullivan-Bissett and Paul Noordhof have objected to this response on the grounds that it employs an undefended conception of the aim of belief not shared by Owens, and that it equivocates between importantly different contexts of doxastic deliberation. In this note, I argue that both of these objections fail. (shrink)

Epistemic instrumentalists think that epistemic normativity is just a special kind of instrumental normativity. According to them, you have epistemic reason to believe a proposition insofar as doing so is conducive to certain epistemic goals or aims—say, to believe what is true and avoid believing what is false. Perhaps the most prominent challenge for instrumentalists in recent years has been to explain, or explain away, why one’s epistemic reasons often do not seem to depend on one’s aims. This challenge can (...) arguably be met. But a different challenge looms: instrumental reasons in the practical domain have various properties that epistemic reasons do not seem to share. In this chapter, we offer a way for epistemic instrumentalists to overcome this challenge. Our main thesis takes the form of a conditional: if we accept an independently plausible transmission principle of instrumental normativity, we can maintain that epistemic reasons in fact do share the relevant properties of practical instrumental reasons. In addition, we can explain why epistemic reasons seem to lack these properties in the first place: some properties of epistemic reasons are elusive, or easy to overlook, because we tend to think and talk about epistemic reasons in an ‘elliptical’ manner. (shrink)