RÉSUMÉ: Bas van Fraassen soutient que le «Principe de Réflexion» constitue une contrainte sur la rationalité et il rattache ce principe à une sorte de volontarisme épistémologique, c’est-à-dire la doctrine selon laquelle la croyance est affaire de volonté. Je soutiens que la version du volontarisme qui est compatible à la fois avec le Principe de Réflexion et avec l’idée de van Fraassen que les jugements épistémiques constituent une forme d’engagement, est tout à fait différente du volontarisme qu’envisageaient William James ou (...) Blaise Pascal. En fait, la prétention de van Fraassen d’avoir établi une théorie libératrice et pragmatique de la connaissance est mise en question par sa propre thèse selon laquelle le Principe de Réflexion sert d’appui à son volontarisme. Van Fraassen ne peut sauver le Principe de Réflexion que dans le cadre d’une théorie de la connaissance plus restrictive que celle qu’il envisage. (shrink)

This article presents the findings of an empirical investigation into the role of third party interventions in the House of Lords. It examines all the judgments in that court from 1994 to 2009 and tests four hypotheses concerning the impact of the Human Rights Act 1998 upon the incidence of interventions and their influence on the decision-making of the Law Lords.

How to Pool Risks across Generations makes the case for the collective provision of pensions, on fair terms of social cooperation. Through the insurance of a mutual association which extends across society and over multiple generations, we share one another's fates by pooling risks across both space and time. Resources are transferred, not simply between different people, but also within the possible future lives of each person: from one's more fortunate to one's less fortunate future selves. The book opens (...) with an investigation of the longevity and investment risk that even a single individual on a desert island would face in providing for her old age. From this atomistic starting point, it builds up, within and across the chapters, to increasingly collective forms of pension provision. By joining together, it is possible to tame the risks we would face as individuals each with our own private pension pot. A collective pension can be justified as a 'social union of social unions': an enduring corporate body, which is formed by agreements to pool risks, in a manner that involves reciprocity between the various individuals that constitute the collective. Even though all individuals age and die, a collective pension scheme remains evergreen, as the average age of members remains relatively unchanged, through the influx of new members to replace those who retire. It is therefore possible to smooth risks indefinitely across as well as within generations, to the mutual advantage of each. (shrink)

Rawlsian justice as fairness is neither fundamentally luck egalitarian nor relational egalitarian. Rather, the most fundamental idea is that of society as a fair system of cooperation. Collective pensions provide a case study which illustrates the fruitfulness of conceiving justice in these latter terms. Those who have recently reached the age of majority do not now know how long they will live in retirement or how well any investments they try to save up for their retirement would fare. From the (...) perspective of the beginning of their working lives, it is therefore rational for each to enter into an agreement with others, who also do not yet know their fates, that, if one turns out to be among the unfortunate whose private pension pots would not have yielded enough for one’s retirement, one will receive much more in retirement, whereas those whose pension pots would have overflowed their retirements will receive somewhat less. These terms are to each person’s expected advantage, which is made possible by a fair sharing of the fruits of social cooperation which arise through the efficiencies reaped by the pooling of the risk of outliving what one could save for one’s retirement on one’s own. It is rational for each to agree to share one another’s fates by pooling risks across both space and time, on fair terms of social cooperation for mutual advantage. Even when collective pensions arise from, and are proportional to, a baseline of unequal income, they can be defended on grounds of reciprocity involving regard for one another as equals. (shrink)

For nearly two centuries, developmental biologists have known that body organs are derived from distinct germ layers. They have argued that adult stem cells formed in one of these, mesoderm for example, cannot give rise to cells that originate in another. We disagree. An exception to this “rule” has been described in crayfish recently. In this species, hemocytes appear to replenish neurogenic cells. This may happen in humans as well. In women who were given male bone marrow‐derived cells, Y chromosome (...) positive cheek cells and brain neurons were detected. While repopulation of these tissues by bone marrow derived cells may not occur normally, and while it does not appear to be terribly efficient, the phenomenon should be studied in more detail. Perhaps cells in the marrow could be used to regenerate tissues elsewhere. (shrink)

How can democratic governments be relied upon to achieve adequate political knowledge when they turn over their authority to those of no epistemic distinction whatsoever? This deep and longstanding concern is one that any proponent of epistemic conceptions of democracy must take seriously. While Condorcetian responses have recently attracted substantial interest, they are largely undermined by a fundamental neglect of agenda-setting. I argue that the apparent intractability of the problem of epistemic adequacy in democracy stems in large part from a (...) failure to appreciate the social character of political knowledge. A social point of view brings into focus a number of vital factors that bear on our understanding of democratic epistemology and our assessment of its prospects: the essential role of inclusive deliberation, the public's agenda-setting function, institutional provisions for policy feedback, the independence of expert communities, and the knowledge-pooling powers of markets. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Influence of Anxiety and Literature's Panglossian NoseMichael AustinIScheherazade may be the protagonist of The Thousand and One Nights, but her stories are the heroes. Her audience for these stories consists only of her sister and her husband, the great sultan Shahryar, who three years earlier had vowed to avenge his wife's infidelity by marrying a new woman each night and executing her the following morning. With the supply (...) of virgins in the kingdom running short, Scheherazade forces her father, the royal vizier, to allow her to marry the Sultan, assuring him that she has a plan to end his bloody practice. Her plan is simple: every night, Scheherazade tells Shahryar a piece of a story. Many of these stories are overtly didactic, and some are even thinly veiled allegories of Shahryar's own situation, but Scheherazade aims to do more than simply rehabilitate the sultan with pedagogically sound morality tales. She weaves her stories together, often using multiple frames and levels of embedded narrative, to make sure that the night always ends in the middle of at least one story, and, each morning, the Sultan postpones his sentence of death one day so he can hear the conclusion.Scheherazade's gambit succeeds—with the Sultan and with readers everywhere—because it taps into a very deep human need for literature, which, broadly defined, includes folk tales, songs, oral epics, and other forms of narrative expression. Stories have been a source of pleasure for human beings for a long time—much longer than there have been writing systems to record them. And, during all this time, as Paul Hernadi writes, "the pleasure of succumbing to literary seduction has long served as a psychological reward for what was once and perhaps still is [End Page 215] a biologically advantageous thing to do."1 Scheherazade's stories give Shahryar pleasure—more pleasure, arguably, than the sexual encounters that precede them. In more than a thousand marriages (assuming three full years since he began the practice), sexual pleasure never entices the sultan to suspend his vow. With an entire kingdom full of potential wives, of course, he need never fear an end to such pleasures. The pool of wives who can bring the pleasure of narrative to the marriage bed is much smaller indeed.But pleasure alone cannot explain Scheherazade's success; if it could, she would not have to end each night in the middle of a story. By doing so, she combines the pleasure of narrative with the anxiety of incompleteness. Scheherazade's cliffhangers work on Shahryar for the same reason that they work on us today: we expect to find out what happens in a story, and we experience anxiety when this expectation is frustrated. This anxiety is just as deeply rooted in biology and natural selection as the "pleasure of succumbing to literary seduction." Most of the things that produce great anxiety in people—such as snakes, spiders, fire, high places, large bodies of water, contaminated surfaces, and unknown social situations—constitute very real threats to our survival. Anxiety is nature's way of telling us to pay extra attention around potentially dangerous things or to take steps to avoid such things whenever possible. Pleasure and anxiety work hand in hand, as carrot and stick, to encourage, or discourage, the same fitness-enhancing behaviors. Eating when we are hungry gives us pleasure; wondering where our next meal is coming from gives us anxiety.The pleasure and anxiety that we experience in literature are neurologically indistinguishable from the same responses that we experience in the life-or-death situations for which they were designed. According to John Tooby and Leda Cosmides, "fictional worlds engage emotion systems while disengaging action systems.... An absorbing series of fictional events will draw out of our mental mechanisms a rich array of emotional responses—the same responses that would be appropriate to those same events and persons if they were real."2 The ability to respond in this way appears to be unique to human beings, but it also appears to be a universal element of human nature. People everywhere tell and respond to stories, and many people devote considerable... (shrink)

How can democratic governments be relied upon to achieve adequate political knowledge when they turn over their authority to those of no epistemic distinction whatsoever? This deep and longstanding concern is one that any proponent of epistemic conceptions of democracy must take seriously. While Condorcetian responses have recently attracted substantial interest, they are largely undermined by a fundamental neglect of agenda-setting. I argue that the apparent intractability of the problem of epistemic adequacy in democracy stems in large part from a (...) failure to appreciate the social character of political knowledge. A social point of view brings into focus a number of vital factors that bear on our understanding of democratic epistemology and our assessment of its prospects: the essential role of inclusive deliberation, the public's agenda-setting function, institutional provisions for policy feedback, the independence of expert communities, and the knowledge-pooling powers of markets. (shrink)

We discuss Herzberg’s :319–337, 2015) treatment of linear aggregation for profiles of infinitely many finitely additive probabilities and suggest a natural alternative to his definition of linear continuous aggregation functions. We then prove generalizations of well-known characterization results due to :410–414, 1981). We also characterize linear aggregation of probabilities in terms of a Pareto condition, de Finetti’s notion of coherence, and convexity.

Alterations in the p53 gene product appear to be a major factor in human tumorigenesis and may influence the responses of many human tumors to therapy. Much effort has focused on understanding the signals which normally initiate p53 growth‐suppressive functions. Though it has been known that DNA damage can induce p53, a recent publication reports data which suggest that p53 can be induced by depletion of ribonucleotide pools, even in the absence of detectable DNA damage(1). These observations provide new ideas (...) about how cells utilize the p53 signal and open up new avenues of investigation for manipulating p53 function. (shrink)

Electronics can be defined as electromagnetic technology dealing with information, and meta-electronics as a field encompassing all the synergistic technologies in which electronics plays a dominant role. Examining the broad field corresponding to this definition we realize that its history starts some seventy years earlier than the customarily accepted birth of electronics, and, what is more significant, that electronics undergoes a true evolution. This new evolution creates rich, diverse structures similar to those created by the biological evolution. Like biology, electronics (...) is non-teleological, which allows for its unlimited evolutionary development. We propose electronic analogies of all essential biological categories, at all levels: population, speciation, common ancestor, phenotype, extended phenotype, co-evolution, convergent evolution, evolutionary arms race, extinction and mass extinction, hierarchical levels, generative entrenchment, genes, alleles, genome, genetic pool, recombination, mutation, genetic drift, lateral gene transfer, etc. The evolutionary algorithm operating in electronics, like a Darwinian one, includes variation within a population of device models, heredity, natural selection, and a form of selection based on aesthetics and fashion which resembles sexual selection. Algorithm is especially similar to artificial selection, thus possessing directionality in the variational part. Electronic development is orders of magnitude faster than biological, accelerated by that directionality and by other distinct, identifiable mechanisms. Speciation in electronics, as in biology, is best represented on a phylogenetic tree, which starts from a common ancestor, but lately exhibits a unification trend. If continued, this trend may lead to the appearance of a common descendant absent in biology. Our analysis may explain emerging anti-social aspects of electronics and our conclusions add new urgency to recent concerns with unchecked development of Artificial Intelligence. (shrink)

The COVID-19 (Coronavirus disease of 2019) pandemic has led to intense conversations about ventilator allocation and reallocation during a crisis standard of care. Multiple voices in the media and multiple state guidelines mention reallocation as a possibility. Drawing upon a range of neuroscientific, phenomenological, ethical, and sociopolitical considerations, the authors argue that taking away someone’s personal ventilator is a direct assault on their bodily and social integrity. They conclude that personal ventilators should not be part of reallocation pools and that (...) triage protocols should be immediately clarified to explicitly state that personal ventilators will be protected in all cases. (shrink)

Merging of opinions results underwrite Bayesian rejoinders to complaints about the subjective nature of personal probability. Such results establish that sufficiently similar priors achieve consensus in the long run when fed the same increasing stream of evidence. Initial subjectivity, the line goes, is of mere transient significance, giving way to intersubjective agreement eventually. Here, we establish a merging result for sets of probability measures that are updated by Jeffrey conditioning. This generalizes a number of different merging results in the literature. (...) We also show that such sets converge to a shared, maximally informed opinion. Convergence to a maximally informed opinion is a (weak) Jeffrey conditioning analogue of Bayesian “convergence to the truth” for conditional probabilities. Finally, we demonstrate the philosophical significance of our study by detailing applications to the topics of dynamic coherence, imprecise probabilities, and probabilistic opinion pooling. (shrink)

The human brain is the only object in the universe, as far as we know, that has discovered its own origins. But what, if any, are the limits of our understanding? Epistemic pessimists, sobered by our humble evolutionary origins, have argued that some truths about the universe are perennial mysteries and will forever remain beyond our ken. Others have brushed this off as premature, a form of epistemic defeatism. In this paper we develop a conceptual toolbox for parsing different forms (...) of cognitive limitation that are often conflated in the literature. We distinguish between representational access and intuitive understanding. We also distinguish different modalities of cognitive limitation. If the scientific endeavor ever comes to a halt, will this feel like slamming into a brick wall, or rather like slowly getting bogged down in a swamp? By distinguishing different types and modalities of human cognitive limitation, we soften up the hypothesis of ‘cognitive closure’ and ultimate ‘mysteries’. Next, we propose specific mechanisms and strategies for overcoming our innate cognitive limitations. For a start, it is uninformative to think of the limits of a single, bare, unassisted brain. One of the central features of human intelligence is the capacity for mind extension and distributed cognition. We have developed various technologies for extending the reach of our naked brains and for pooling their cognitive resources, as witnessed by the history of science. We then discuss different cognitive mechanisms for overcoming the limits to our intuitive understanding, and argue that these are combinatorial and open-ended. In light of all these possibilities for extending the limits of our understanding, we conclude that there is no good reason to suspect the existence of an outer wall of human comprehension. (shrink)

Jacques Derrida is, in the words of the_ New York Times_, "perhaps the world's most famous philosopher—if not the only famous philosopher." He often provokes controversy as soon as his name is mentioned. But he also inspires the respect that comes from an illustrious career, and, among many who were his colleagues and peers, he inspired friendship. _The Work of Mourning_ is a collection that honors those friendships in the wake of passing. Gathered here are texts—letters of condolence, memorial essays, (...) eulogies, funeral orations—written after the deaths of well-known figures: Roland Barthes, Paul de Man, Michel Foucault, Louis Althusser, Edmond Jabès, Louis Marin, Sarah Kofman, Gilles Deleuze, Emmanuel Levinas, Jean-François Lyotard, Max Loreau, Jean-Marie Benoist, Joseph Riddel, and Michel Servière. With his words, Derrida bears witness to the singularity of a friendship and to the absolute uniqueness of each relationship. In each case, he is acutely aware of the questions of tact, taste, and ethical responsibility involved in speaking of the dead—the risks of using the occasion for one's own purposes, political calculation, personal vendetta, and the expiation of guilt. More than a collection of memorial addresses, this volume sheds light not only on Derrida's relation to some of the most prominent French thinkers of the past quarter century but also on some of the most important themes of Derrida's entire oeuvre-mourning, the "gift of death," time, memory, and friendship itself. "In his rapt attention to his subjects' work and their influence upon him, the book also offers a hesitant and tangential retelling of Derrida's own life in French philosophical history. There are illuminating and playful anecdotes—how Lyotard led Derrida to begin using a word-processor; how Paul de Man talked knowledgeably of jazz with Derrida's son. Anyone who still thinks that Derrida is a facetious punster will find such resentful prejudice unable to survive a reading of this beautiful work."—Steven Poole, _Guardian_ "Strikingly _simpa_ meditations on friendship, on shared vocations and avocations and on philosophy and history."—_Publishers Weekly _. (shrink)

Jacques Derrida is, in the words of the_ New York Times_, "perhaps the world's most famous philosopher—if not the only famous philosopher." He often provokes controversy as soon as his name is mentioned. But he also inspires the respect that comes from an illustrious career, and, among many who were his colleagues and peers, he inspired friendship. _The Work of Mourning_ is a collection that honors those friendships in the wake of passing. Gathered here are texts—letters of condolence, memorial essays, (...) eulogies, funeral orations—written after the deaths of well-known figures: Roland Barthes, Paul de Man, Michel Foucault, Louis Althusser, Edmond Jabès, Louis Marin, Sarah Kofman, Gilles Deleuze, Emmanuel Levinas, Jean-François Lyotard, Max Loreau, Jean-Marie Benoist, Joseph Riddel, and Michel Servière. With his words, Derrida bears witness to the singularity of a friendship and to the absolute uniqueness of each relationship. In each case, he is acutely aware of the questions of tact, taste, and ethical responsibility involved in speaking of the dead—the risks of using the occasion for one's own purposes, political calculation, personal vendetta, and the expiation of guilt. More than a collection of memorial addresses, this volume sheds light not only on Derrida's relation to some of the most prominent French thinkers of the past quarter century but also on some of the most important themes of Derrida's entire oeuvre-mourning, the "gift of death," time, memory, and friendship itself. "In his rapt attention to his subjects' work and their influence upon him, the book also offers a hesitant and tangential retelling of Derrida's own life in French philosophical history. There are illuminating and playful anecdotes—how Lyotard led Derrida to begin using a word-processor; how Paul de Man talked knowledgeably of jazz with Derrida's son. Anyone who still thinks that Derrida is a facetious punster will find such resentful prejudice unable to survive a reading of this beautiful work."—Steven Poole, _Guardian_ "Strikingly _simpa_ meditations on friendship, on shared vocations and avocations and on philosophy and history."—_Publishers Weekly _. (shrink)

Frank Miller and I recently argued that the common assertion that ‘brain dead’ patients merely appear to be alive, though in reality are dead, is false.1 This assertion relies on an inaccurate and overly simplistic understanding of the role of medical technology in the physiology of a ‘brain dead’ patient. In response, Symons and Chua endorsed our conclusions regarding the vital status of the ventilated ‘brain dead’ patient, and then pursued the question: what does this imply if we are to (...) preserve the dead donor rule?2 To their credit, Symons and Chua unflinchingly acknowledge that if we seek to maintain the dead donor rule then we must restrict not expand the donor pool because ‘brain dead’ individuals are still living. This would mean fewer organs, and hence more deaths of those on the waiting list. This is the price of holding to the conviction that doctors must never kill patients in order to procure organs for transplantation. Of course, that has always been the price: the dead donor rule is principally a deontic prohibition, not a consequentialist rule designed to maximise good outcomes. Symons’s and Chua’s view is a valid position in the debate on death and the ethics of vital organ procurement, and …. (shrink)

Prominent philosophers have argued that contradictions contain either too much or too little information to be useful. We dispute this with what we call the “Paradox of the Two Firefighters.” Suppose you are awakened in your hotel room by a fire alarm. You open the door. You see three possible ways out: left, right, straight ahead. You see two firefighters. One says there is exactly one safe route and it is to your left. The other says there is exactly one (...) safe route and it is to your right. While the two firemen are giving you contradictory information, they are also both giving you the perhaps useful information that there is a safe way out and it is not straight ahead. We give two analyses. The first uses the “Opinion Tetrahedron,” introduced by Dunn as a generalization of Audun Jøsang’s “Opinion Triangle.” The Opinion Tetrahedron in effect embeds the values of the “Belnap-Dunn 4-valued Logic” into a context of subjective probability generalized to allow for degrees of belief, disbelief, and two kinds of uncertainty—that in which the reasoner has too little information and that in which the reasoner has too much information. Jøsang had only a single value for uncertainty. We also present an alternative solution, again based on subjective probability but of a more standard type. This solution builds upon “linear opinion pooling.” Kiefer had already developed apparatus for assessing risk using expert opinion, and this influences the second solution. Finally, we discuss how these solutions might apply to “Big Data” and the World Wide Web. (shrink)

In 2016, Davis and Zhang surveyed 71 Chinese engineers to investigate the claim that the concept of “profession” may have a far wider range than the term. They concluded that China seems to have a profession of engineering even though the Chinese still lacked an exact translation of the English term. In part, the survey reported here simply continues the work of Davis and Zhang. It confirms their result using a much larger, better educated, demographically different pool of 229 (...) Chinese engineers. But, in part too, it does something else. It investigates the concept professional competence—the perceived knowledge, skill, and judgment that those surveyed attribute to themselves and other engineers. The article has four parts. The first part describes the basics of the survey. The second part describes some important features of the survey’s questions, explaining how the questions closely track both the concept of profession and the concept of professional competence. The third part reports and interprets the results relevant to the presence or absence of the concepts of profession and professional competence. The fourth part reports the conclusions. (shrink)

Decades of research conducted in Western, Educated, Industrialized, Rich, & Democratic (WEIRD) societies have led many scholars to conclude that the use of mental states in moral judgment is a human cognitive universal, perhaps an adaptive strategy for selecting optimal social partners from a large pool of candidates. However, recent work from a more diverse array of societies suggests there may be important variation in how much people rely on mental states, with people in some societies judging accidental harms (...) just as harshly as intentional ones. To explain this variation, we develop and test a novel cultural evolutionary theory proposing that the intensity of kin-based institutions will favor less attention to mental states when judging moral violations. First, to better illuminate the historical distribution of the use of intentions in moral judgment, we code and analyze anthropological observations from the Human Area Relations Files. This analysis shows that notions of strict liability—wherein the role for mental states is reduced—were common across diverse societies around the globe. Then, by expanding an existing vignette-based experimental dataset containing observations from 321 people in a diverse sample of 10 societies, we show that the intensity of a society's kin-based institutions can explain a substantial portion of the population-level variation in people's reliance on intentions in three different kinds of moral judgments. Together, these lines of evidence suggest that people's use of mental states has coevolved culturally to fit their local kin-based institutions. We suggest that although reliance on mental states has likely been a feature of moral judgment in human communities over historical and evolutionary time, the relational fluidity and weak kin ties of today's WEIRD societies position these populations' psychology at the extreme end of the global and historical spectrum. (shrink)

We introduce new leader humility scales capturing a theoretically rich conceptualization of leader-expressed humility aligned with traditional and ethically-grounded philosophies. These scales draw from recent inductive research (Oc et al., 2015) identifying nine dimensions of leader-expressed humility: (1) having an accurate view of self, (2) recognizing follower strengths and achievements, (3) modeling teachability and being correctable, (4) leading by example, (5) showing modesty, (6) working together for the collective good, (7) empathy and approachability, (8) showing mutual respect and fairness, and (...) (9) mentoring and coaching. The first three dimensions overlap with the most prominent conceptualization of leader-expressed humility in the literature (i.e., Owens et al., 2013). However, the latter six dimensions are unique and represent an expanded understanding of the humble behaviors of leaders, which have implications for leaders and their ethical behavior in organizations. We conducted three studies resulting in two versions of the leader-expressed humility measure: 1) a 27-item scale with the nine dimensions (i.e., the “Leader-Expressed Humility” [LEH] scale) and 2) a 9-item brief scale (i.e., the “Brief LEH” scale) comprised of one item from each of the nine dimensions. As an initial step, we generated a pool of items that reflected each dimension. Next, we validated the LEH and Brief LEH scales in Study 1 and cross-validated the Brief LEH scale in Study 2 with two samples of subordinates in Singapore. As a final step, in Study 3, we cross-validated the Brief LEH scale with a sample of subordinates in the United States. (shrink)

Intra- and intergroup conflict are likely to have been recurrent features of human evolutionary history; however, little research has investigated the factors that affect men’s combat alliance decisions. The current study investigated whether features of previous one-on-one combat with an opponent affect men’s interest in allying with that opponent for future group combat. Fifty-eight undergraduate men recruited from a psychology department subject pool participated in a one-on-one laboratory fight simulation. We manipulated fight outcome, perceived fighter health asymmetry, and the (...) presence of a witness over six sets of five rounds of fighting. Following each set, we asked men how interested they would be in allying with their opponent for future group combat. We found that men were more interested in allying with their opponent for future group combat if their opponent won the fight or if a witness was present, but perceived fighter-health asymmetry did not affect men’s decision to ally with their opponent. Exploratory analyses revealed a two-way interaction between fight outcome and the presence of a witness, such that winners without a witness present expressed less interest in allying with their opponent for future group combat. Our findings suggest that men attend to the benefits of allying with a man who has demonstrated relatively superior fighting ability. Alliance with a previous opponent for group combat may vary with the relationship value of the opponent and the utility of demonstrating cooperativeness to third-party observers. These findings inform our understanding of coalition formation. (shrink)

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. (...) The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)

The output from motor neuron pools is influenced by the integration of synaptic inputs originating from descending corticomotor and spinal reflex pathways. In this study, using paired non-invasive brain and peripheral nerve stimulation, we investigated how descending corticomotor pathways influence the physiologic recruitment order of the soleus Hoffmann reflex. Eleven neurologically unimpaired adults completed an assessment of transcranial magnetic stimulation -conditioning of the soleus H-reflex over a range of peripheral nerve stimulation intensities. Unconditioned H-reflex recruitment curves were obtained by delivering (...) PNS pulses to the posterior tibial nerve. Subsequently, TMS-conditioned H-reflex recruitment curves were obtained by pairing PNS with subthreshold TMS at short and long intervals. We evaluated unconditioned and TMS-conditioned H-reflex amplitudes along the ascending limb, peak, and descending limb of the H-reflex recruitment curve. Our results revealed that, for long-interval facilitation, TMS-conditioned H-reflex amplitudes were significantly larger than unconditioned H-reflex amplitudes along the ascending limb and peak of the H-reflex recruitment curve. Additionally, significantly lower PNS intensities were needed to elicit peak H-reflex amplitude for long-interval facilitation compared to unconditioned. These findings suggest that the influence of descending corticomotor pathways, particularly those mediating long-interval facilitation, contribute to changing the recruitment gain of the motor neuron pool, and can inform future methodological protocols for TMS-conditioning of H-reflexes. By characterizing and inducing short-term plasticity in circuitry mediating short- and long-interval TMS-conditioning of H-reflex amplitudes, future studies can investigate supraspinal and spinal circuit contributions to abnormal motor control, as well as develop novel therapeutic targets for neuromodulation. (shrink)

We study shared intentions in what we call “loose groups”. These are groups that lack a codified organizational structure, and where the communication channels between group members are either unreliable or not completely open. We start by formulating two desiderata for shared intentions in such groups. We then argue that no existing account meets these two desiderata, because they assume either too strong or too weak an epistemic condition, that is, a condition on what the group members know and believe (...) about what the others intend, know, and believe. We propose an alternative, pooled knowledge, and argue that it allows formulating conditions on shared intentions that meet the two desiderata. (shrink)

In this paper, we explore how a conversational theory of moral responsibility can provide illuminating resources for building a theory about the nature and norms of moral forgiveness.

Drawing on work of the past decade, this volume brings together articles from the philosophy, history, and sociology of science, and many other branches of the biological sciences. The volume delves into the latest theoretical controversies as well as burning questions of contemporary social importance. The issues considered include the nature of evolutionary theory, biology and ethics, the challenge from religion, and the social implications of biology today (in particular the Human Genome Project).

Transformation of the sparrow and the butterfly -- Meeting the gods of poverty in a dream -- The greatest joys of the cicada and its cast-off shell -- The owl's understanding -- The centipede questions the snake -- The toad's way of the gods -- The mysterious technique of the cat -- Afterword by William Scott Wilson.

We are material beings in a material world, but we are also beings who have experiences and feelings. How can these subjective states be just a matter of matter? To defend materialism, philosophical materialists have formulated what is sometimes called "the phenomenal-concept strategy," which holds that we possess a range of special concepts for classifying the subjective aspects of our experiences. In Consciousness Revisited, the philosopher Michael Tye, until now a proponent of the the phenomenal-concept strategy, argues that the (...) strategy is mistaken. A rejection of phenomenal concepts leaves the materialist with the task of finding some other strategy for defending materialism. Tye points to four major puzzles of consciousness that arise: How is it possible for Mary, in the famous thought experiment, to make a discovery when she leaves her black-and-white room? In what does the explanatory gap consist and how can it be bridged? How can the hard problem of consciousness be solved? How are zombies possible? Tye presents solutions to these puzzles -- solutions that relieve the pressure on the materialist created by the failure of the phenomenal-concept strategy. In doing so, he discusses and makes new proposals on a wide range of issues, including the nature of perceptual content, the conditions necessary for consciousness of a given object, the proper understanding of change blindness, the nature of phenomenal character and our awareness of it, whether we have privileged access to our own experiences, and, if we do, in what such access consists. (shrink)

In _Reconstructing the Cognitive World_, Michael Wheeler argues that we should turn away from the generically Cartesian philosophical foundations of much contemporary cognitive science research and proposes instead a Heideggerian approach. Wheeler begins with an interpretation of Descartes. He defines Cartesian psychology as a conceptual framework of explanatory principles and shows how each of these principles is part of the deep assumptions of orthodox cognitive science. Wheeler then turns to Heidegger's radically non-Cartesian account of everyday cognition, which, he argues, (...) can be used to articulate the philosophical foundations of a genuinely non-Cartesian cognitive science. Finding that Heidegger's critique of Cartesian thinking falls short, even when supported by Hubert Dreyfus's influential critique of orthodox artificial intelligence, Wheeler suggests a new Heideggerian approach. He points to recent research in "embodied-embedded" cognitive science and proposes a Heideggerian framework to identify, amplify, and clarify the underlying philosophical foundations of this new work. He focuses much of his investigation on recent work in artificial intelligence-oriented robotics, discussing, among other topics, the nature and status of representational explanation, and whether cognition is computation rather than a noncomputational phenomenon best described in the language of dynamical systems theory. Wheeler's argument draws on analytic philosophy, continental philosophy, and empirical work to "reconstruct" the philosophical foundations of cognitive science in a time of a fundamental shift away from a generically Cartesian approach. His analysis demonstrates that Heideggerian continental philosophy and naturalistic cognitive science need not be mutually exclusive and shows further that a Heideggerian framework can act as the "conceptual glue" for new work in cognitive science. (shrink)

In Unnatural Doubts, Michael Williams constructs a masterly polemic against the very idea of epistemology, as traditionally conceived.

The two dominant theories of consciousness argue it appeared in living beings either suddenly, or gradually. Both theories face problems. The solution is the realization that a foundational consciousness was always here, yet varying conscious states were not, and appeared gradually. Michael Tye explores this idea and the key questions it raises.

The System of Pragmatic Idealism is of special importance for Nicholas Rescher's philosophical work, because here he has presented the systematic approach at once. Dedicated to his 70th birthday a group of European and U.S-american philosophers discuss the main topics of Rescher's philosophical system. The contributions which are presented here for the first time and Nicholas Rescher's responses cover the most important topics of philosophy and give a deep and detailed insight into the strenght of Rescher's pragmatic idealism. This volume (...) is of interest for philosophers studying Rescher's philosophy and for all those who are interested in systematic philosophy and the vividnes of pragmatism and idealism in present philosophy. (shrink)

Anna J Dare,1 Anthony RJ Phillips,1–3 Michael Chu,1 Anthony JR Hickey,2 Adam SJR Bartlett1–31Department of Surgery, 2Maurice Wilkins Centre for Biodiscovery, University of Auckland, Auckland, New Zealand; 3New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New ZealandBackground: Hepatic steatosis is increasingly encountered among organ donors. Currently, there is no consensus guideline as to the type or degree of donor steatosis considered acceptable for liver transplantation, and little is known about local practices in this area. The aim of this (...) survey was to evaluate current clinical practices amongst liver transplant surgeons in Australia and New Zealand in the evaluation and use of steatotic donor livers in LT.Methods: An anonymous online twelve-question survey was emailed to all practicing LT surgeons in ANZ in January 2010.Results: The response rate was 83%. Estimated prevalence of steatosis in donor livers was between 40% and 60%. In determining suitability for LT, 90% of respondents reported rejecting organs with "severe" steatosis based on visual and palpation grounds alone. A total of 68% sought further histological assessment if the donor liver looked bad and there were risk factors for steatosis. The majority of respondents performed only one biopsy of the liver, using hematoxylin and eosin staining for fat assessment. There was wide variation in the upper limit of steatosis considered to be acceptable for LT. A total of 21% of respondents still considered microvesicular steatosis a risk factor for primary graft nonfunction.Conclusion: This survey highlights the significant variation in the appraisal and use of steatotic grafts by LT surgeons in ANZ. Accurate evaluation and judicious use of mild and moderately steatotic grafts is required if we are to utilize the available donor pool best.Keywords: liver transplantation, steatosis, fatty liver, organ donors. (shrink)

Disjunctivism about perceptual appearances, as I conceive of it, is a theory which seeks to preserve a naïve realist conception of veridical perception in the light of the challenge from the argument from hallucination. The naïve realist claims that some sensory experiences are relations to mind-independent objects. That is to say, taking experiences to be episodes or events, the naïve realist supposes that some such episodes have as constituents mind-independent objects. In turn, the disjunctivist claims that in a case of (...) veridical perception like this very kind of experience that you now have, the experiential episode you enjoy is of a kind which could not be occurring were you having an hallucination. The common strategy of arguments from hallucination set out to show that certain things are true of hallucinations, and hence must be true of perceptions. For example, it is argued that hallucinations must have non-physical objects of awareness, or that such states are not relations to anything at all, but are at best seeming relations to objects. In insisting that veridical perceptual experience is of a distinct kind from hallucination, the disjunctivist denies that any of these conceptions of hallucination challenges our conception of veridical perceptions as relations to mind-independent objects. More specifically, I assume that the disjunctivist advocates naïve realism because they think that this position best articulates how sensory experience seems to us to be just through reflection. If the disjunctivist is correct in this contention, then anyone who accepts the conclusion of the argument from hallucination must also accept that the nature of sensory experience is other than it seems to us to be. In turn, one may complain that any such error theory is liable to lead to sceptical consequences. A Humean scepticism about the senses launches a challenge about our knowledge of the world through questioning the conception we have of what sense experience is, and how it can provide knowledge of the world. (shrink)

A consideration of some of the most common questions about animal minds.Do birds have feelings? Can fish feel pain? Could a honeybee be anxious? For centuries, the question of whether or not animals are conscious like humans has prompted debates among philosophers and scientists. While most people gladly accept that complex mammals - such as dogs - share emotions and experiences with us, the matter of simpler creatures is much less clear. Meanwhile, the advent of the digital age and artificial (...) intelligence has created an added dimension to questions about non-human consciousness. In Tense Bees and Shell-Shocked Crabs, Michael Tye offers answers to some of today's most pressing questions about nonhuman consciousness. Blending the latest research about animal sensation with theories about the nature of consciousness, Tye develops a methodology for addressing the mysteries of the animal mind. Without endorsing any specific theory on the nature of consciousness, Tye tackles issues such as the animal experience of pain and fear, and the role of brain anatomy in determining consciousness. He then turns his attention to the artificial realm, considering whether complex robots could ever be considered conscious. Tye concludes with a discussion of how, if we consider animals conscious, this might impact our ethical obligations to them. From insects to crabs, fish to birds, Tense Bees and Shell-Shocked Crabs offers an insightful exploration of the ways in which animals relate to the world. Tense Bees and Shell-Shocked Crabs will appeal to students and scholars of philosophy and neuroscience, as well as general readers with an interest in animal and environmental ethics. (shrink)