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  1. People With Parkinson’s Disease and Freezing of Gait Show Abnormal Low Frequency Activity of Antagonistic Leg Muscles.Maria-Sophie Breu, Marlieke Schneider, Johannes Klemt, Idil Cebi, Alireza Gharabaghi & Daniel Weiss - 2022 - Frontiers in Human Neuroscience 15.
    ObjectiveFreezing of gait is detrimental to patients with idiopathic Parkinson’s disease. Its pathophysiology represents a multilevel failure of motor processing in the cortical, subcortical, and brainstem circuits, ultimately resulting in ineffective motor output of the spinal pattern generator. Electrophysiological studies pointed to abnormalities of oscillatory activity in freezers that covered a broad frequency range including the theta, alpha, and beta bands. We explored muscular frequency domain activity with respect to freezing, and used deep brain stimulation to modulate these rhythms thereby (...)
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  2. Does Prefrontal Glutamate Index Cognitive Changes in Parkinson’s Disease?Isabelle Buard, Natalie Lopez-Esquibel, Finnuella J. Carey, Mark S. Brown, Luis D. Medina, Eugene Kronberg, Christine S. Martin, Sarah Rogers, Samantha K. Holden, Michael R. Greher & Benzi M. Kluger - 2022 - Frontiers in Human Neuroscience 16.
    IntroductionCognitive impairment is a highly prevalent non-motor feature of Parkinson’s disease. A better understanding of the underlying pathophysiology may help in identifying therapeutic targets to prevent or treat dementia. This study sought to identify metabolic alterations in the prefrontal cortex, a key region for cognitive functioning that has been implicated in cognitive dysfunction in PD.MethodsProton Magnetic Resonance Spectroscopy was used to investigate metabolic changes in the PFC of a cohort of cognitively normal individuals without PD, as well as PD participants (...)
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  3. Relationship Dynamics of Couples Facing Advanced-Stage Parkinson’s Disease: A Dyadic Interpretative Phenomenological Analysis.Emilie Constant, Elodie Brugallé, Emilie Wawrziczny, Céline Sokolowski, Charlotte Manceau, Bérengère Flinois, Guillaume Baille, Defebvre Luc, Kathy Dujardin & Pascal Antoine - 2022 - Frontiers in Psychology 12.
    Background/ObjectiveSeveral studies have examined the impact of Parkinson’s disease on the quality of couples’ relationships. To date, few studies have explored how couples experience their relationship dynamic by taking into account the disease stage. The objectives of this study were to understand the experience of each partner and to study the mechanisms that underlie their couple organization in the advanced stage of PD.MethodsSemistructured individual interviews conducted with fifteen patients and their partners were the subject of a dyadic interpretative phenomenological analysis.ResultsThree (...)
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  4. Perceptions on Using Surplus Embryos for the Treatment of Parkinson’s Disease Among the Swedish Population: A Qualitative Study.Jennifer Drevin & Åsa Grauman - 2022 - BMC Medical Ethics 23 (1):1-9.
    BackgroundHuman embryonic stem cells are currently used for developing treatment against Parkinson’s disease. However, the use of ES cells is surrounded with moral concerns. Research regarding the public's attitudes can form an important basis for policymaking. The aim was to explore the perceptions of the public on using donated human embryos for developing treatment of Parkinson’s Disease.MethodsSemi-structured individual qualitative interviews were conducted with 11 members of the general population in Sweden. Interviews were analyzed with thematic content analyses.ResultsFour categories and additional (...)
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  5. Commentary: A Longitudinal Randomized Controlled Trial Protocol to Evaluate the Effects of Wuqinxi on Dynamic Functional Connectivity in Parkinson's Disease Patients.Yifan Gong, Dongli Wang & Zhibin Liu - 2022 - Frontiers in Human Neuroscience 16.
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  6. Comparison of Shod and Unshod Gait in Patients With Parkinson's Disease With Subthalamic and Nigral Stimulation.Martin A. Horn, Alessandro Gulberti, Ute Hidding, Christian Gerloff, Wolfgang Hamel, Christian K. E. Moll & Monika Pötter-Nerger - 2022 - Frontiers in Human Neuroscience 15.
    Background: The Parkinsonian [i.e., Parkinson's disease ] gait disorder represents a therapeutical challenge with residual symptoms despite the use of deep brain stimulation of the subthalamic nucleus and medical and rehabilitative strategies. The aim of this study was to assess the effect of different DBS modes as combined stimulation of the STN and substantia nigra and environmental rehabilitative factors as footwear on gait kinematics.Methods: This single-center, randomized, double-blind, crossover clinical trial assessed shod and unshod gait in patients with PD with (...)
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  7. Using Motor Imagery to Access Alternative Attentional Strategies When Navigating Environmental Boundaries to Prevent Freezing of Gait – A Perspective.Daniella How, Heiko Wagner & Michael Brach - 2022 - Frontiers in Human Neuroscience 16.
    Freezing of gait can cause reduced independence and quality of life for many with Parkinson’s disease. Episodes frequently occur at points of transition such as navigating a doorway. Therapeutic interventions, i.e., drugs and exercise, do not always successfully mitigate episodes. There are several different, but not exclusive causes for freezing of gait. People with freezing of gait are able to navigate dynamic situations like stairways by utilizing a different attentional strategy to over-ground walking, but may freeze when passing through a (...)
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  8. Effects of Exercise on Parkinson’s Disease: A Meta-Analysis of Brain Imaging Studies.Jingwen Li, Jian Guo, Weijuan Sun, Jinjin Mei, Yiying Wang, Lihong Zhang, Jianyun Zhang, Jing Gao, Kaiqi Su, Zhuan Lv, Xiaodong Feng & Ruiqing Li - 2022 - Frontiers in Human Neuroscience 16.
    BackgroundExercise is increasingly recognized as a key component of Parkinson’s disease treatment strategies, but the underlying mechanism of how exercise affects PD is not yet fully understood.ObjectiveThe activation likelihood estimation method is used to study the mechanism of exercise affecting PD, providing a theoretical basis for studying exercise and PD, and promoting the health of patients with PD.MethodsRelevant keywords were searched on the PubMed, Cochrane Library, and Web of Science databases. Seven articles were finally included according to the screening criteria, (...)
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  9. Machine Learning-Based Analysis of Digital Movement Assessment and ExerGame Scores for Parkinson's Disease Severity Estimation.Dunia J. Mahboobeh, Sofia B. Dias, Ahsan H. Khandoker & Leontios J. Hadjileontiadis - 2022 - Frontiers in Psychology 13.
    Neurodegenerative Parkinson's Disease is one of the common incurable diseases among the elderly. Clinical assessments are characterized as standardized means for PD diagnosis. However, relying on medical evaluation of a patient's status can be subjective to physicians' experience, making the assessment process susceptible to human errors. The use of ICT-based tools for capturing the status of patients with PD can provide more objective and quantitative metrics. In this vein, the Personalized Serious Game Suite and intelligent Motor Assessment Tests, produced within (...)
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  10. Review—Emerging Portable Technologies for Gait Analysis in Neurological Disorders.Christina Salchow-Hömmen, Matej Skrobot, Magdalena C. E. Jochner, Thomas Schauer, Andrea A. Kühn & Nikolaus Wenger - 2022 - Frontiers in Human Neuroscience 16.
    The understanding of locomotion in neurological disorders requires technologies for quantitative gait analysis. Numerous modalities are available today to objectively capture spatiotemporal gait and postural control features. Nevertheless, many obstacles prevent the application of these technologies to their full potential in neurological research and especially clinical practice. These include the required expert knowledge, time for data collection, and missing standards for data analysis and reporting. Here, we provide a technological review of wearable and vision-based portable motion analysis tools that emerged (...)
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  11. Subthalamic Deep Brain Stimulation Lead Asymmetry Impacts the Parkinsonian Gait Disorder.Frederik P. Schott, Alessandro Gulberti, Hans O. Pinnschmidt, Christian Gerloff, Christian K. E. Moll, Miriam Schaper, Johannes A. Koeppen, Wolfgang Hamel & Monika Pötter-Nerger - 2022 - Frontiers in Human Neuroscience 16.
    BackgroundThe preferable position of Deep Brain Stimulation electrodes is proposed to be located in the dorsolateral subthalamic nucleus to improve general motor performance. The optimal DBS electrode localization for the post-operative improvement of balance and gait is unknown.MethodsIn this single-center, retrospective analyses, 66 Parkinson’s disease patients were assessed pre- and post-operatively by using MDS-UPDRS, freezing of gait score, Giladi’s gait and falls questionnaire and Berg balance scale. The clinical outcome was related to the DBS electrode coordinates in x, y, z (...)
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  12. Visual Perturbation Suggests Increased Effort to Maintain Balance in Early Stages of Parkinson’s to Be an Effect of Age Rather Than Disease.Justus Student, David Engel, Lars Timmermann, Frank Bremmer & Josefine Waldthaler - 2022 - Frontiers in Human Neuroscience 16.
    Postural instability marks a prevalent symptom of Parkinson’s disease. It often manifests in increased body sway, which is commonly assessed by tracking the Center of Pressure. Yet, in terms of postural control, the body’s Center of Mass, and not CoP is what is regulated in a gravitational field. The aim of this study was to explore the effect of early- to mid-stage PD on these measures of postural control in response to unpredictable visual perturbations. We investigated three cohorts: 18 patients (...)
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  13. Quantitative Analysis for the Delineation of the Subthalamic Nuclei on Three-Dimensional Stereotactic MRI Before Deep Brain Stimulation Surgery for Medication-Refractory Parkinson’s Disease.Chun-Yu Su, Alex Mun-Ching Wong, Chih-Chen Chang, Po-Hsun Tu, Chiung Chu Chen & Chih-Hua Yeh - 2022 - Frontiers in Human Neuroscience 16.
    Delineation of the subthalamic nuclei on MRI is critical for deep brain stimulation surgery in patients with Parkinson’s disease. We propose this retrospective cohort study for quantitative analysis of MR signal-to-noise ratio, contrast, and signal difference-to-noise ratio of the STN on pre-operative three-dimensional stereotactic MRI in patients with medication-refractory PD. Forty-five consecutive patients with medication-refractory PD who underwent STN-DBS surgery in our hospital from January 2018 to June 2021 were included in this study. All patients had whole-brain 3D MRI, including (...)
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  14. Case Report: Bilateral Deep Brain Stimulation Implantation on Different Targets for a Parkinson's Disease Patient With a Bullet in the Brain.Yu Tian, Jiaming Wang, Xin Shi, Zhaohai Feng, Lei Jiang & Yujun Hao - 2022 - Frontiers in Human Neuroscience 15.
    Patients requiring deep brain stimulation due to intracerebral metallic foreign substances have not been reported elsewhere in the world. Additionally, the long-term effects of metallic foreign bodies on deep brain stimulation are unknown. A 79-year-old man with a 5-year history of Parkinson's disease reported that, 40 years ago, while playing with a pistol, a metallic bullet was accidentally discharged into the left brain through the edge of the left eye, causing no discomfort other than blurry vision in the left eye. (...)
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  15. Dopamine-Related Reduction of Semantic Spreading Activation in Patients With Parkinson’s Disease.Hannes Ole Tiedt, Felicitas Ehlen & Fabian Klostermann - 2022 - Frontiers in Human Neuroscience 16.
    Impaired performance in verbal fluency tasks is a frequent observation in Parkinson’s disease. As to the nature of the underlying cognitive deficit, it is commonly attributed to a frontal-type dysexecutive syndrome due to nigrostriatal dopamine depletion. Whereas dopaminergic medication typically improves VF performance in PD, e.g., by ameliorating impaired lexical switching, its effect on semantic network activation is unclear. Data from priming studies suggest that dopamine causes a faster decay of semantic activation spread. The aim of the current study was (...)
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  16. Combined Subthalamic and Nigral Stimulation Modulates Temporal Gait Coordination and Cortical Gait-Network Activity in Parkinson’s Disease.Jonas R. Wagner, Miriam Schaper, Wolfgang Hamel, Manfred Westphal, Christian Gerloff, Andreas K. Engel, Christian K. E. Moll, Alessandro Gulberti & Monika Pötter-Nerger - 2022 - Frontiers in Human Neuroscience 16.
    BackgroundFreezing of gait is a disabling burden for Parkinson’s disease patients with poor response to conventional therapies. Combined deep brain stimulation of the subthalamic nucleus and substantia nigra moved into focus as a potential therapeutic option to treat the parkinsonian gait disorder and refractory FoG. The mechanisms of action of DBS within the cortical-subcortical-basal ganglia network on gait, particularly at the cortical level, remain unclear.MethodsTwelve patients with idiopathic PD and chronically-implanted DBS electrodes were assessed on their regular dopaminergic medication in (...)
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  17. The Smart Aging Platform for Assessing Early Phases of Cognitive Impairment in Patients With Neurodegenerative Diseases.Sara Bottiroli, Sara Bernini, Elena Cavallini, Elena Sinforiani, Chiara Zucchella, Stefania Pazzi, Paolo Cristiani, Tomaso Vecchi, Daniela Tost, Giorgio Sandrini & Cristina Tassorelli - 2021 - Frontiers in Psychology 12.
    Background: Smart Aging is a serious game platform that generates a 3D virtual reality environment in which users perform a set of screening tasks designed to allow evaluation of global cognition. Each task replicates activities of daily living performed in a familiar environment. The main goal of the present study was to ascertain whether Smart Aging could differentiate between different types and levels of cognitive impairment in patients with neurodegenerative disease.Methods: Ninety-one subjects —healthy older adults, patients with single-domain amnesic mild (...)
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  18. Mild Cognitive Impairment in de Novo Parkinson's Disease: Selective Attention Deficit as Early Sign of Neurocognitive Decay.Davide Maria Cammisuli, Cristina Pagni, Giovanni Palermo, Daniela Frosini, Joyce Bonaccorsi, Claudia Radicchi, Simona Cintoli, Luca Tommasini, Gloria Tognoni, Roberto Ceravolo & Ubaldo Bonuccelli - 2021 - Frontiers in Psychology 12.
    Background: In the present study, we aimed to better investigate attention system profile of Parkinson's disease-Mild Cognitive Impairment patients and to determine if specific attentional deficits are associated with 123I-FP-CIT SPECT.Methods: A total of 44 de novo drug-naïve PD patients [ with normal cognition and 17 with MCI ], 23 MCI patients and 23 individuals with subjective cognitive impairment were recruited at the Clinical Neurology Unit of Santa Chiara hospital. They were assessed by a wide neuropsychological battery, including Visual Search (...)
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  19. Prediction of Freezing of Gait in Parkinson’s Disease Using a Random Forest Model Based on an Orthogonal Experimental Design: A Pilot Study.Zhonelue Chen, Gen Li, Chao Gao, Yuyan Tan, Jun Liu, Jin Zhao, Yun Ling, Xiaoliu Yu, Kang Ren & Shengdi Chen - 2021 - Frontiers in Human Neuroscience 15.
    PurposeThe purpose of this study was to introduce an orthogonal experimental design to improve the efficiency of building and optimizing models for freezing of gait prediction.MethodsA random forest model was developed to predict FOG by using acceleration signals and angular velocity signals to recognize possible precursor signs of FOG. An OED was introduced to optimize the feature extraction parameters.ResultsThe main effects and interaction among the feature extraction hyperparameters were analyzed. The false-positive rate, hit rate, and mean prediction time were 27%, (...)
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  20. C-Gait for Detecting Freezing of Gait in the Early to Middle Stages of Parkinson’s Disease: A Model Prediction Study.Zi-Yan Chen, Hong-Jiao Yan, Lin Qi, Qiao-Xia Zhen, Cui Liu, Ping Wang, Yong-Hong Liu, Rui-Dan Wang, Yan-Jun Liu, Jin-Ping Fang, Yuan Su, Xiao-Yan Yan, Ai-Xian Liu, Jianing Xi & Boyan Fang - 2021 - Frontiers in Human Neuroscience 15.
    GraphicalPatients with early- to middle-stage PD were enrolled for C-Gait assessment and traditional walking ability assessments. The correlation of C-Gait assessment and traditional walking tests were studied. Two models were established based on C-Gait assessment and traditional walking tests to explore the value of C-Gait assessment in predicting freezing of gait.ObjectiveEfficient methods for assessing walking adaptability in individuals with Parkinson’s disease are urgently needed. Therefore, this study aimed to assess C-Gait for detecting freezing of gait in patients with early- to (...)
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  21. BeatWalk: Personalized Music-Based Gait Rehabilitation in Parkinson’s Disease.Valérie Cochen De Cock, Dobromir Dotov, Loic Damm, Sandy Lacombe, Petra Ihalainen, Marie Christine Picot, Florence Galtier, Cindy Lebrun, Aurélie Giordano, Valérie Driss, Christian Geny, Ainara Garzo, Erik Hernandez, Edith Van Dyck, Marc Leman, Rudi Villing, Benoit G. Bardy & Simone Dalla Bella - 2021 - Frontiers in Psychology 12.
    Taking regular walks when living with Parkinson’s disease has beneficial effects on movement and quality of life. Yet, patients usually show reduced physical activity compared to healthy older adults. Using auditory stimulation such as music can facilitate walking but patients vary significantly in their response. An individualized approach adapting musical tempo to patients’ gait cadence, and capitalizing on these individual differences, is likely to provide a rewarding experience, increasing motivation for walk-in PD. We aim to evaluate the observance, safety, tolerance, (...)
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  22. Assistive HCI-Serious Games Co-Design Insights: The Case Study of I-PROGNOSIS Personalized Game Suite for Parkinson’s Disease.Sofia Balula Dias, José Alves Diniz, Evdokimos Konstantinidis, Theodore Savvidis, Vicky Zilidou, Panagiotis D. Bamidis, Athina Grammatikopoulou, Kosmas Dimitropoulos, Nikos Grammalidis, Hagen Jaeger, Michael Stadtschnitzer, Hugo Silva, Gonçalo Telo, Ioannis Ioakeimidis, George Ntakakis, Fotis Karayiannis, Estelle Huchet, Vera Hoermann, Konstantinos Filis, Elina Theodoropoulou, George Lyberopoulos, Konstantinos Kyritsis, Alexandros Papadopoulos, Anastasios Depoulos, Dhaval Trivedi, Ray K. Chaudhuri, Lisa Klingelhoefer, Heinz Reichmann, Sevasti Bostantzopoulou, Zoe Katsarou, Dimitrios Iakovakis, Stelios Hadjidimitriou, Vasileios Charisis, George Apostolidis & Leontios J. Hadjileontiadis - 2021 - Frontiers in Psychology 11.
    Human-Computer Interaction and games set a new domain in understanding people’s motivations in gaming, behavioral implications of game play, game adaptation to player preferences and needs for increased engaging experiences in the context of HCI serious games. When the latter relate with people’s health status, they can become a part of their daily life as assistive health status monitoring/enhancement systems. Co-designing HCI-SGs can be seen as a combination of art and science that involves a meticulous collaborative process. The design elements (...)
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  23. The Role of Social Cognition Abilities in Parkinson's Disease in the Era of COVID-19 Emergency.Alessandra Dodich, Costanza Papagno, Luca Turella, Claudia Meli, Francesca Zappini, Pamela Narduzzi, Alessandro Gober, Enrica Pierotti & Marika Falla - 2021 - Frontiers in Psychology 12.
    Introduction: Parkinson's Disease is characterized by motor and non-motor symptoms, among which deficits in social cognition might affect ~20% of patients. This study aims to evaluate the role of social cognitive abilities in the perceived impact of COVID-19 emergency, and the effects of lockdown measures on patients' social network and caregivers' burden.Methods: Fourteen PD patients performed a neuropsychological battery including sociocognitive tasks before the introduction of COVID-19 restrictive measures. A structured interview through an online platform was performed in the last (...)
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  24. ‘Woe Betides Anybody Who Tries to Turn me Down.’ A Qualitative Analysis of Neuropsychiatric Symptoms Following Subthalamic Deep Brain Stimulation for Parkinson’s Disease.Philip E. Mosley, Katherine Robinson, Terry Coyne, Peter Silburn, Michael Breakspear & Adrian Carter - 2021 - Neuroethics 14 (1):47-63.
    Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease can lead to the development of neuropsychiatric symptoms. These can include harmful changes in mood and behaviour that alienate family members and raise ethical questions about personal responsibility for actions committed under stimulation-dependent mental states. Qualitative interviews were conducted with twenty participants following subthalamic DBS at a movement disorders centre, in order to explore the meaning and significance of stimulation-related neuropsychiatric symptoms amongst a purposive sample of persons (...)
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  25. Incoming Ethical Issues for Deep Brain Stimulation: When Long-Term Treatment Leads to a ‘New Form of the Disease’.Frederic Gilbert & Mathilde Lancelot - 2021 - Journal of Medical Ethics 47 (1):20-25.
    Deep brain stimulation has been regarded as an efficient and safe treatment for Parkinson’s disease since being approved by the Food and Drug Administration in 1997. It is estimated that more than 150 000 patients have been implanted, with a forecasted rapid increase in uptake with population ageing. Recent longitudinal follow-up studies have reported a significant increase in postoperative survival rates of patients with PD implanted with DBS as compared with those not implanted with DBS. Although DBS tends to increase (...)
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  26. Trading Vulnerabilities: Living with Parkinson’s Disease Before and After Deep Brain Stimulation.Sara Goering, Anna Wexler & Eran Klein - 2021 - Cambridge Quarterly of Healthcare Ethics 30 (4):623-630.
    Implanted medical devices—for example, cardiac defibrillators, deep brain stimulators, and insulin pumps—offer users the possibility of regaining some control over an increasingly unruly body, the opportunity to become part “cyborg” in service of addressing pressing health needs. We recognize the value and effectiveness of such devices, but call attention to what may be less clear to potential users—that their vulnerabilities may not entirely disappear but instead shift. We explore the kinds of shifting vulnerabilities experienced by people with Parkinson’s disease who (...)
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  27. A Neuromotor to Acoustical Jaw-Tongue Projection Model With Application in Parkinson’s Disease Hypokinetic Dysarthria.Andrés Gómez, Pedro Gómez, Daniel Palacios, Victoria Rodellar, Víctor Nieto, Agustín Álvarez & Athanasios Tsanas - 2021 - Frontiers in Human Neuroscience 15.
    Aim: The present work proposes the study of the neuromotor activity of the masseter-jaw-tongue articulation during diadochokinetic exercising to establish functional statistical relationships between surface Electromyography, 3D Accelerometry, and acoustic features extracted from the speech signal, with the aim of characterizing Hypokinetic Dysarthria. A database of multi-trait signals of recordings from an age-matched control and PD participants are used in the experimental study. Hypothesis: The main assumption is that information between sEMG and 3D acceleration, and acoustic features may be quantified (...)
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  28. Cospeech Gestures Are a Window Into the Effects of Parkinson’s Disease on Action Representations.Stacey Humphries, Judith Holler, Trevor Crawford & Ellen Poliakoff - 2021 - Journal of Experimental Psychology: General 150 (8):1581-1597.
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  29. Voice Analysis to Differentiate the Dopaminergic Response in People With Parkinson's Disease.Anubhav Jain, Kian Abedinpour, Ozgur Polat, Mine Melodi Çalışkan, Afsaneh Asaei, Franz M. J. Pfister, Urban M. Fietzek & Milos Cernak - 2021 - Frontiers in Human Neuroscience 15.
    Humans' voice offers the widest variety of motor phenomena of any human activity. However, its clinical evaluation in people with movement disorders such as Parkinson's disease lags behind current knowledge on advanced analytical automatic speech processing methodology. Here, we use deep learning-based speech processing to differentially analyze voice recordings in 14 people with PD before and after dopaminergic medication using personalized Convolutional Recurrent Neural Networks and Phone Attribute Codebooks. p-CRNN yields an accuracy of 82.35% in the binary classification of ON (...)
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  30. Altered Inhibitory Mechanisms in Parkinson’s Disease: Evidence From Lexical Decision and Simple Reaction Time Tasks.Alban Letanneux, Jean-Luc Velay, François Viallet & Serge Pinto - 2021 - Frontiers in Human Neuroscience 15.
    IntroductionAlthough the motor signs of Parkinson’s disease are well defined, nonmotor symptoms, including higher-level language deficits, have also been shown to be frequent in patients with PD. In the present study, we used a lexical decision task to find out whether access to the mental lexicon is impaired in patients with PD, and whether task performance is affected by bradykinesia.Materials and MethodsParticipants were 34 nondemented patients with PD, either without medication or under optimum medication. A total of 19 age-matched control (...)
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  31. Intraoperative Characterization of Subthalamic Nucleus-to-Cortex Evoked Potentials in Parkinson’s Disease Deep Brain Stimulation.Lila H. Levinson, David J. Caldwell, Jeneva A. Cronin, Brady Houston, Steve I. Perlmutter, Kurt E. Weaver, Jeffrey A. Herron, Jeffrey G. Ojemann & Andrew L. Ko - 2021 - Frontiers in Human Neuroscience 15.
    Deep brain stimulation of the subthalamic nucleus is a clinically effective tool for treating medically refractory Parkinson’s disease, but its neural mechanisms remain debated. Previous work has demonstrated that STN DBS results in evoked potentials in the primary motor cortex, suggesting that modulation of cortical physiology may be involved in its therapeutic effects. Due to technical challenges presented by high-amplitude DBS artifacts, these EPs are often measured in response to low-frequency stimulation, which is generally ineffective at PD symptom management. This (...)
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  32. Revisiting the L-Dopa Response as a Predictor of Motor Outcomes After Deep Brain Stimulation in Parkinson’s Disease.Zhengyu Lin, Xiaoxiao Zhang, Linbin Wang, Yingying Zhang, Haiyan Zhou, Qingfang Sun, Bomin Sun, Peng Huang & Dianyou Li - 2021 - Frontiers in Human Neuroscience 15.
    Objective: To investigate the correlation between preoperative response to the L-dopa challenge test and efficacy of deep brain stimulation on motor function in Parkinson’s disease.Methods: We retrospectively reviewed the data of 38 patients with idiopathic PD who underwent DBS surgery with a median follow-up duration of 7 months. Twenty underwent bilateral globus pallidus interna DBS, and 18 underwent bilateral subthalamic nucleus DBS. The Movement Disorder Society Unified Parkinson Disease Rating Scale-Motor Part was assessed before surgery and at the last follow-up (...)
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  33. Arithmetic Errors in Financial Contexts in Parkinson’s Disease.Hannah D. Loenneker, Sara Becker, Susanne Nussbaum, Hans-Christoph Nuerk & Inga Liepelt-Scarfone - 2021 - Frontiers in Psychology 12.
    Research on dyscalculia in neurodegenerative diseases is still scarce, despite high impact on patients’ independence and activities of daily living function. Most studies address Alzheimer’s Disease; however, patients with Parkinson’s Disease also have a higher risk for cognitive impairment while the relation to arithmetic deficits in financial contexts has rarely been studied. Therefore, the current exploratory study investigates deficits in two simple arithmetic tasks in financial contexts administered within the Clinical Dementia Rating in a sample of 100 PD patients. Patients (...)
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  34. Global Variability in Deep Brain Stimulation Practices for Parkinson’s Disease.Abhimanyu Mahajan, Ankur Butala, Michael S. Okun, Zoltan Mari & Kelly A. Mills - 2021 - Frontiers in Human Neuroscience 15.
    IntroductionDeep brain stimulation has become a standard treatment option for select patients with Parkinson’s disease. The selection process and surgical procedures employed have, to date, not been standardized.MethodsA comprehensive 58-question web-based survey was developed with a focus on DBS referral practices and peri-operative management. The survey was distributed to the Parkinson’s Foundation Centers of Excellence, members of the International Parkinson’s Disease and Movement Disorders Society, and the Parkinson Study Group between December 2015 and May 2016.ResultsThere were 207 individual respondents drawn (...)
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  35. Closed-Loop Deep Brain Stimulation to Treat Medication-Refractory Freezing of Gait in Parkinson’s Disease.Rene Molina, Chris J. Hass, Stephanie Cernera, Kristen Sowalsky, Abigail C. Schmitt, Jaimie A. Roper, Daniel Martinez-Ramirez, Enrico Opri, Christopher W. Hess, Robert S. Eisinger, Kelly D. Foote, Aysegul Gunduz & Michael S. Okun - 2021 - Frontiers in Human Neuroscience 15.
    Background: Treating medication-refractory freezing of gait in Parkinson’s disease remains challenging despite several trials reporting improvements in motor symptoms using subthalamic nucleus or globus pallidus internus deep brain stimulation. Pedunculopontine nucleus region DBS has been used for medication-refractory FoG, with mixed findings. FoG, as a paroxysmal phenomenon, provides an ideal framework for the possibility of closed-loop DBS.Methods: In this clinical trial, five subjects with medication-refractory FoG underwent bilateral GPi DBS implantation to address levodopa-responsive PD symptoms with open-loop stimulation. Additionally, PPN (...)
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  36. Individual Magnetoencephalography Response Profiles to Short-Duration L-Dopa in Parkinson’s Disease.Edgar Peña, Tareq M. Mohammad, Fedaa Almohammed, Tahani AlOtaibi, Shahpar Nahrir, Sheraz Khan, Vahe Poghosyan, Matthew D. Johnson & Jawad A. Bajwa - 2021 - Frontiers in Human Neuroscience 15.
    Clinical responses to dopamine replacement therapy for individuals with Parkinson’s disease are often difficult to predict. We characterized changes in MDS-UPDRS motor factor scores resulting from a short-duration L-Dopa response, and investigated how the inter-subject clinical differences could be predicted from motor cortical magnetoencephalography. MDS-UPDRS motor factor scores and resting-state MEG recordings were collected during SDR from twenty individuals with a PD diagnosis. We used a novel subject-specific strategy based on linear support vector machines to quantify motor cortical oscillatory frequency (...)
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  37. The Space Between Words: On the Description of Parkinson’s Disease in Jonathan Franzen’s 'The Corrections'.Ben Rutter & Rodney Hermeston - 2021 - Medical Humanities 47 (1):56-60.
    Disability or health-related literature has potential to shape public understanding of disability and can also play an important role in medical curricula. However, there appears to be a gap between a health humanities approach which may embrace fictional accounts and a cultural disability studies approach which is deeply sceptical of fiction written by non-disabled authors. This paper seeks to reconcile these perspectives and presents an analysis of the language used by Jonathan Franzen in his description of Parkinson’s disease in the (...)
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  38. The Effect of Dopaminergic Replacement Therapy on Creative Thinking and Insight Problem-Solving in Parkinson's Disease Patients.Carola Salvi, Emily K. Leiker, Beatrix Baricca, Maria A. Molinari, Roberto Eleopra, Paolo F. Nichelli, Jordan Grafman & Joseph E. Dunsmoor - 2021 - Frontiers in Psychology 12.
    Parkinson's disease patients receiving dopaminergic treatment may experience bursts of creativity. Although this phenomenon is sometimes recognized among patients and their clinicians, the association between dopamine replacement therapy in PD patients and creativity remains underexplored. It is unclear, for instance, whether DRT affects creativity through convergent or divergent thinking, idea generation, or a general lack of inhibition. It is also unclear whether DRT only augments pre-existing creative attributes or generates creativity de novo. Here, we tested a group of PD patients (...)
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  39. 7T MRI and Computational Modeling Supports a Critical Role of Lead Location in Determining Outcomes for Deep Brain Stimulation: A Case Report.Lauren E. Schrock, Remi Patriat, Mojgan Goftari, Jiwon Kim, Matthew D. Johnson, Noam Harel & Jerrold L. Vitek - 2021 - Frontiers in Human Neuroscience 15.
    Subthalamic nucleus deep brain stimulation is an established therapy for Parkinson’s disease motor symptoms. The ideal site for implantation within STN, however, remains controversial. While many argue that placement of a DBS lead within the sensorimotor territory of the STN yields better motor outcomes, others report similar effects with leads placed in the associative or motor territory of the STN, while still others assert that placing a DBS lead “anywhere within a 6-mm-diameter cylinder centered at the presumed middle of the (...)
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  40. Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.Vinata Vedam-Mai, Karl Deisseroth, James Giordano, Gabriel Lazaro-Munoz, Winston Chiong, Nanthia Suthana, Jean-Philippe Langevin, Jay Gill, Wayne Goodman, Nicole R. Provenza, Casey H. Halpern, Rajat S. Shivacharan, Tricia N. Cunningham, Sameer A. Sheth, Nader Pouratian, Katherine W. Scangos, Helen S. Mayberg, Andreas Horn, Kara A. Johnson, Christopher R. Butson, Ro’ee Gilron, Coralie de Hemptinne, Robert Wilt, Maria Yaroshinsky, Simon Little, Philip Starr, Greg Worrell, Prasad Shirvalkar, Edward Chang, Jens Volkmann, Muthuraman Muthuraman, Sergiu Groppa, Andrea A. Kühn, Luming Li, Matthew Johnson, Kevin J. Otto, Robert Raike, Steve Goetz, Chengyuan Wu, Peter Silburn, Binith Cheeran, Yagna J. Pathak, Mahsa Malekmohammadi, Aysegul Gunduz, Joshua K. Wong, Stephanie Cernera, Aparna Wagle Shukla, Adolfo Ramirez-Zamora, Wissam Deeb, Addie Patterson, Kelly D. Foote & Michael S. Okun - 2021 - Frontiers in Human Neuroscience 15.
    We estimate that 208,000 deep brain stimulation devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. The (...)
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  41. Bodily Felt Freedom: an Ethical Perspective on Positive Aspects of Deep Brain Stimulation.Julia Sophia Voigt - 2021 - Neuroethics 14 (1):45-57.
    The critical aspects of deep brain stimulation are usually the focus of the ethical debate about the implantation of electrodes into the brain of patients with Parkinson’s disease. Above all, potential postoperative side effects on personality caused by DBS mark the debate. However, rehabilitation of agility and mobility by DBS can be posited against critical aspects. Therefore, the purpose of this article is to emphasize the hitherto neglected positive aspects of that technology. A detailed study of the rehabilitation of controlled (...)
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  42. The Effects of Working Memory Updating Training in Parkinson’s Disease: A Feasibility and Single-Subject Study on Cognition, Movement and Functional Brain Response.Lois Walton, Magdalena Eriksson Domellöf, Carl-Johan Boraxbekk, Erik Domellöf, Louise Rönnqvist, David Bäckström, Lars Forsgren & Anna Stigsdotter Neely - 2021 - Frontiers in Psychology 11.
    In Parkinson’s disease, the fronto-striatal network is involved in motor and cognitive symptoms. Working memory updating training engages this network in healthy populations, as observed by improved cognitive performance and increased striatal BOLD signal. This two-part study aimed to assess the feasibility of WM updating training in PD and measure change in cognition, movement and functional brain response in one individual with PD after WM updating training. A feasibility and single-subject study were performed in which patients with PD completed computerized (...)
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  43. Safety and Tolerability of Burst-Cycling Deep Brain Stimulation for Freezing of Gait in Parkinson’s Disease.Joshua K. Wong, Wei Hu, Ryan Barmore, Janine Lopes, Kathryn Moore, Joseph Legacy, Parisa Tahafchi, Zachary Jackson, Jack W. Judy, Robert S. Raike, Anson Wang, Takashi Tsuboi, Michael S. Okun & Leonardo Almeida - 2021 - Frontiers in Human Neuroscience 15.
    Background: Freezing of gait is a common symptom in Parkinson’s disease and can be difficult to treat with dopaminergic medications or with deep brain stimulation. Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation delivers current in various frequencies of bursts, while maintaining an intra-burst frequency identical to conventional DBS.Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG.Methods: Ten PD subjects with STN or GPi DBS (...)
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  44. Deep Brain Stimulation for Parkinson’s Disease During the COVID-19 Pandemic: Patient Perspective.Chencheng Zhang, Jing Zhang, Xian Qiu, Yingying Zhang, Zhengyu Lin, Peng Huang, Yixin Pan, Eric A. Storch, Bomin Sun & Dianyou Li - 2021 - Frontiers in Human Neuroscience 15.
    BackgroundPublic health guidelines have recommended that elective medical procedures, including deep brain stimulation surgery for Parkinson’s disease, should not be scheduled during the coronavirus pandemic to prevent further virus spread and overload on health care systems. However, delaying DBS surgery for PD may not be in the best interest of individual patients and is not called for in regions where virus spread is under control and inpatient facilities are not overloaded.MethodsWe administered a newly developed phone questionnaire to 20 consecutive patients (...)
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  45. Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson’s Disease.Guanyu Zhang, Jinghong Ma, Piu Chan & Zheng Ye - 2021 - Frontiers in Psychology 12.
    The ability to sequence thoughts and actions is impaired in Parkinson’s disease. In PD, a distinct error pattern has been found in the offline performance of sequential working memory. This study examined how PD’s performance of sequential working memory unfolds over time using mouse tracking techniques. Non-demented patients with mild PD and healthy controls completed a computerized digit ordering task with a computer mouse. We measured response dynamics in terms of the initiation time, ordering time, movement time, and area under (...)
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  46. Perspective: Evolution of Control Variables and Policies for Closed-Loop Deep Brain Stimulation for Parkinson’s Disease Using Bidirectional Deep-Brain-Computer Interfaces.Helen M. Bronte-Stewart, Matthew N. Petrucci, Johanna J. O’Day, Muhammad Furqan Afzal, Jordan E. Parker, Yasmine M. Kehnemouyi, Kevin B. Wilkins, Gerrit C. Orthlieb & Shannon L. Hoffman - 2020 - Frontiers in Human Neuroscience 14.
  47. Improving Self-Awareness of Motor Symptoms in Patients With Parkinson’s Disease by Using Mindfulness – A Study Protocol for a Randomized Controlled Trial.Timo Marcel Buchwitz, Franziska Maier, Andrea Greuel & Carsten Eggers - 2020 - Frontiers in Psychology 11.
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  48. “I Want to Do It, But I Want to Make Sure That I Do It Right.” Views of Patients with Parkinson’s Disease Regarding Early Stem Cell Clinical Trial Participation.Inmaculada de Melo-Martín, Michael Holtzman & Katrina S. Hacker - 2020 - AJOB Empirical Bioethics 11 (3):160-171.
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  49. Corticomotor Excitability Changes Associated With Freezing of Gait in People With Parkinson Disease.Ya-Yun Lee, Min-Hao Li, Chun-Hwei Tai & Jer-Junn Luh - 2020 - Frontiers in Human Neuroscience 14.
  50. Alterations of Interhemispheric Functional Connectivity in Parkinson’s Disease With Depression: A Resting-State Functional MRI Study.Haiyan Liao, Jie Fan, Qin Shen, Sainan Cai, Min Wang, Chunyu Wang, Hainan Zhang, Jun Liu, Xiongzhao Zhu & Changlian Tan - 2020 - Frontiers in Human Neuroscience 14.
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