Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease can lead to the development of neuropsychiatric symptoms. These can include harmful changes in mood and behaviour that alienate family members and raise ethical questions about personal responsibility for actions committed under stimulation-dependent mental states. Qualitative interviews were conducted with twenty participants following subthalamic DBS at a movement disorders centre, in order to explore the meaning and significance of stimulation-related neuropsychiatric symptoms amongst a purposive sample of persons (...) with PD and their spousal caregivers. Interview transcripts underwent inductive thematic analysis. Clinical and experiential aspects of post-DBS neuropsychiatric symptoms were identified. Caregivers were highly burdened by these symptoms and both patients and caregivers felt unprepared for their consequences, despite having received information prior to DBS, desiring greater family and peer engagement prior to neurosurgery. Participants held conflicting opinions as to whether emergent symptoms were attributable to neurostimulation. Many felt that they reflected aspects of the person’s “real” or “younger” personality. Those participants who perceived a close relationship between stimulation changes and changes in mental state were more likely to view these symptoms as inauthentic and uncontrollable. Unexpected and troublesome neuropsychiatric symptoms occurred despite a pre-operative education programme that was delivered to all participants. This suggests that such symptoms are difficult to predict and manage even if best practice guidelines are followed by experienced centres. Further research aimed at predicting these complications may improve the capacity of clinicians to tailor the consent process. (shrink)
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. (...) The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)
DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)
Peter Abelard was one of the most influential writers and thinkers of the twelfth century, famed for his skill in logic as well as his romance with Heloise. His Collationes - or Dialogue between a Christian, a Philosopher, and a Jew - is remarkable for the boldness of its conception and thought.
Peter Abelard (1079 – 21 April 1142) [‘Abailard’ or ‘Abaelard’ or ‘Habalaarz’ and so on] was the pre-eminent philosopher and theologian of the twelfth century. The teacher of his generation, he was also famous as a poet and a musician. Prior to the recovery of Aristotle, he brought the native Latin tradition in philosophy to its highest pitch. His genius was evident in all he did. He is, arguably, the greatest logician of the Middle Ages and is equally famous (...) as the first great nominalist philosopher. He championed the use of reason in matters of faith (he was the first to use ‘theology’ in its modern sense), and his systematic treatment of religious doctrines are as remarkable for their philosophical penetration and subtlety as they are for their audacity. Abelard seemed larger than life to his contemporaries: his quick wit, sharp tongue, perfect memory, and boundless arrogance made him unbeatable in debate — he was said by supporter and detractor alike never to have lost an argument — and the force of his personality impressed itself vividly on all with whom he came into contact. His luckless affair with Héloïse made him a tragic figure of romance, and his conflict with Bernard of Clairvaux over reason and religion made him the hero of the Enlightenment. For all his colourful life, though, his philosophical achievements are the cornerstone of his fame. (shrink)
The primary aim of this important study is to produce a reliable account of Peter Martyr’s life before he left Italy in 1542. Earlier biographers had been content to follow the Swiss Calvinist Josiah Simler, who knew Peter Martyr in later years, delivered his funeral oration and published it in 1563. Dr McNair has tried ‘to delve beneath Simler to contemporary records’. He has discovered, for example, that Peter Martyr was born in 1499 not, as is usually (...) said, in 1500. He has been concerned to find out when Peter Martyr left his order and his Church, suggesting that there is little reason to believe that his apostasy began in his years at the University of Padua, 1518-26; it was in Naples, between 1537 and 1540, when he came to know Juan de Valdés, that Peter Martyr’s conversion took place. ‘He arrived a reformer after the order of Ximénez, he left a reformer after the order of Zwingli’, writes Dr McNair, meaning by this the Zwingli of the years immediately before 1523, when he wished to go further than Erasmus but not so far as Luther. (shrink)
Chora L Works documents the unprecedented collaboration, initiated in 1985, between philosopher Jacques Derrida and architect Peter Eisenman on a project for the Parc de la Villette in Paris. Woven into the volume are discussion transcripts, candid correspondence, and essays, as well as sketches, presentation drawings, and models. Derrida and Eisenman's design process was guided by Plato's chora text from the Timeaus; their unique reciprocal relationship was an interchange - and transformation - of voices.
Define ‘het’ as a predicate that truly applies to itself if and only if it does not truly apply to itself and which also truly applies to any predicate that does not truly apply to its own name. We know that the attempted definition of ‘hes’ is a failure, and so a fortiori is that of ‘het’. Similarly, there is no Qussell class which contains itself as a member if and only if it does not contain itself as a member, (...) so a fortiori there is no Russell Class which contains itself as a member if and only if it does not contain itself as a member and which also contains all and only non-self-membered classes (such as the class of dogs). The second conjunct in both the definition of ‘het’ and of the Russell class cannot revive a definition doomed to failure. Likewise, the ‘definition’ of n as ‘n > 1 iff n < 1’ fails, and the attempted definition of m as ‘m > 1 iff m < 1 and m is prime’ is hopeless too; its final clause buys it no respectability. (shrink)
The metaphysics of relations is still in its infancy. We use the idea of truthmaking to gain purchase on this metaphysics. Assuming a modest supervenience conception of truthmaking, where true relational predications require multiply dependent truthmakers, these are indispensable relations. Though some such relations are required, none are needed for internal relatedness, nor for several other kinds of relational predication. Discerning the metaphysically basic kinds of relations is fraught with uncertainties, but must be tackled if progress is to be made.
Peter Singer is probably the best-known and most controversial ethicist in the world today. He rigorously applies utilitarian moral theory to issues such as world poverty, the environment, abortion, euthanasia and, most famously, animal welfare. He has also written a book about his grandfather, David Oppenheim, who died in Theresienstadt concentration camp. He is Ira W. DeCamp Professor of Bioethics at Princeton University.
Written by eminent philosophers from Britain, Europe, America, and Australia, the essays of this collection are a tribute to Peter Winch, whose work is marked by his deep appreciation of the most fundamental aspect of Wittgenstein's legacy: that we cannot detach our concepts from their roots in human life. The voices in this volume unite in different tones of sympathy and criticism by discussing the theme of human conditioning: the human conditioning of what we can find intelligible, possible and (...) impossible, and the suspicion of an illusory transcendence. (shrink)
Histories of philosophy frequently depict the later eleventh century as the scene of a series of bouts between dialecticians and anti-dialecticians — Berengar vs. Lanfranc, Roscelin vs. Anselm — preliminaries to the twelfth century welterweight contest between Abelard and St. Bernard and — dare one say? — the thirteenth century heavy-weight championship between St. Thomas and St. Bonaventure.The bouts took place — no question about that — but whether the contestants can properly be characterized as dialecticians and anti-dialecticians is less (...) certain. Dialectics is logic, the third part of the trivium, and increasingly cultivated in the eleventh century; men like Berengar and Roscelin were plainly eager to apply the logical tools with which they had been equipped to the solution of intellectual problems. In particular they undertook the solution of certain central problems of theology — Berengar that of the Eucharist and Roscelin that of the Trinity — and it was this, we are told, that aroused the ire of the anti-dialecticians: if the aim of the dialecticians was to lay bare the mysteries of faith to the light of reason that of the anti-dialecticians was to protect those same mysteries from profanation. (shrink)
Peter Singer is probably the best-known and most controversial ethicist in the world today. He rigorously applies utilitarian moral theory to issues such as world poverty, the environment, abortion, euthanasia and, most famously, animal welfare. He has also written a book about his grandfather, David Oppenheim, who died in Theresienstadt concentration camp. He is Ira W. DeCamp Professor of Bioethics at Princeton University.
The idea of immanent transcendence is constitutive for Winch's philosophy of religion and his ethics. Winch's philosophy of religion insists on the ‘immanent’ dimension of religion. His ethics insists on the ‘transcendent’ dimension of ethics. In this sense, both religion and ethics embody a perspective ‘beyond’ this world and yet must have practical consequences in this world. Transcendence without immanence is idle, and immanence without transcendence is empty—this is the kernel of Winch's philosophy of religion and of his ethics.
