Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network function implicated in major depression. Because a prominent clinical feature of depression is anhedonia--the inability to experience pleasure from previously pleasurable activities--and because there is clear evidence of dysfunctions of the reward system in depression, DBS to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. Three patients suffering from extremely resistant forms of depression, who did not respond to pharmacotherapy, psychotherapy, (...) and electroconvulsive therapy, were implanted with bilateral DBS electrodes in the nucleus accumbens. Stimulation parameters were modified in a double-blind manner, and clinical ratings were assessed at each modification. Additionally, brain metabolism was assessed 1 week before and 1 week after stimulation onset. Clinical ratings improved in all three patients when the stimulator was on, and worsened in all three patients when the stimulator was turned off. Effects were observable immediately, and no side effects occurred in any of the patients. Using FDG-PET, significant changes in brain metabolism as a function of the stimulation in fronto-striatal networks were observed. No unwanted effects of DBS other than those directly related to the surgical procedure (eg pain at sites of implantation) were observed. Dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. These preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression. (shrink)

Transcranial magnetic stimulation is a relatively non-invasive technique to interfere with the function of small cortical areas through currents induced by alternating magnetic fields emanating from a handheld coil placed directly above the targeted area. This technique has clear effects on a whole range of measures of brain function and has become an important research tool in neuropsychiatry. More recently, TMS has been studied in psychiatry mainly to assess its putative therapeutic effects in the treatment of refractory major depression. Most (...) studies indicate that both low-frequency TMS and higher frequency repetitive TMS may have some antidepressant properties. This is most interesting and opens a whole new avenue of low invasive techniques to stimulate the brain in major depression. However, definite therapeutic effects of clinical significance still remain to be demonstrated. (shrink)

The notion of reduction continues to play a key role in philosophy of mind and philosophy of cognitive science. Supporters of reductionism claim that psychological properties or explanations reduce to neural properties or explanations, while antireductionists claim that such reductions are not possible. In this book, I apply recent developments in philosophy of science, particularly the mechanistic explanation paradigm and the interventionist theory of causation, to reassess the traditional approaches to reduction in philosophy of mind. I then elaborate and defend (...) a pluralistic framework for philosophy of mind, and show how reductionist ideas can be incorporated into it. This leads to a novel synthesis of pluralism and reductionism that I call pluralistic physicalism. (shrink)

Recently Kenneth Kendler and Peter Zachar have raised doubts about the correspondence theory of truth and scientific realism in psychopathology. They argue that coherentist or pragmatist approaches to truth are better suited for understanding the reality of psychiatric disorders. In this article, I show that rejecting realism based on the correspondence theory is deeply problematic: It makes psychopathology categorically different from other sciences, and results in an implausible view of scientific discovery and progress. As an alternative, I suggest a robustness-based (...) approach that can accommodate the significance of coherence and pragmatic factors without rejecting scientific realism and the correspondence theory of truth. (shrink)

I propose a new way of understanding Kant’s doctrine of freedom. My reading seeks to combine features of two popular opposed lines of interpretation, namely, of metaphysical and anti-metaphysical readings. I defend the view that Kant’s idealist attempt to ‘save’ human freedom involves substantive metaphysical commitments. However, I show that this interpretation can fruitfully integrate important insights that are standardly associated with deflationary readings: first, the idea that for Kant freedom and natural necessity can be ascribed to one and the (...) same human being; and second, the idea that for Kant the belief in freedom and the belief in natural necessity belong to two different standpoints. (shrink)

Finding causes is a central goal in psychological research. In this paper, I argue based on the interventionist approach to causal discovery that the search for psychological causes faces great obstacles. Psychological interventions are likely to be fat-handed: they change several variables simultaneously, and it is not known to what extent such interventions give leverage for causal inference. Moreover, due to problems of measurement, the degree to which an intervention was fat-handed, or more generally, what the intervention in fact did, (...) is difficult to reliably estimate. A further complication is that the causal findings in psychology are typically made at the population level, and such findings do not allow inferences to individual-level causal relationships. I also discuss the implications of these problems for research, as well as various ways of addressing them, such as focusing more on the discovery of robust but non-causal patterns. (shrink)

We propose that the fundamental mechanism underlying resilience is the integration of novel or negative experiences into internal schemata. This process requires a switch from reactive to predictive control modes, from the brain's salience network to the default mode network. Reappraisal, among other mechanisms, is suggested to facilitate this process.

In this paper, I first explore Hegel’s own distinctions between various types of idealism, most of which he explicitly rejects. I discuss his notions of subjective, transcendental and absolute idealism and present the outlines of his criticisms of the first two as well as the motivation behind his commitment to a version of absolute idealism. In particular, I argue that the latter does not share the defining features of what is now commonly called ‘idealism’, as Hegel neither denies the existence (...) of an external world nor even holds that we can only somehow indirectly infer the truth of propositions about the external world from the structure of some given mental material. I give a basic account of what Hegel’s concept of ‘the absolute idea’ is about, which lies behind his absolute idealism. In this context, I maintain that it is crucial for our understanding of Hegel and of his potential relevance for contemporary metaphysics and epistemology that the absolute idea is precisely not a mental or ‘spiritual’ (geistig) entity. Rather, it amounts to a set of methodological assumptions designed to guarantee the overall intelligibility of what there is, regardless of its actual natural, social or more broadly normative structure. (shrink)

Humans are unconditionally confronted with social expectations and norms, up to a degree that they, or some of them, have a hard time recognizing what they actually want. This renders them susceptible for introjection, that is, to unwittingly or “unconsciously” mistake social expectations for self-chosen goals. Such introjections compromise an individual’s autonomy and mental health and have been shown to be more prevalent in individuals with rumination tendencies and low emotional self-awareness. In this brain imaging study, we draw on a (...) source memory task and found that introjections, as indicated by imposed tasks that are falsely recognized as self-chosen, involved the bilateral medial prefrontal cortex and the dorsal anterior cingulate cortex. Notably, reduced right MPFC activation within this condition correlated with trait scores of ruminations and reduced emotional self-awareness, but also introversion. Moreover, correct recognition of tasks as self-chosen involved the right MPFC. Accordingly, the right MPFC may play a role in supporting the maintenance of psychological autonomy and counteract introjection, which individuals with certain personality traits seem to be prone to. This research has significant implications for the study of mechanisms underlying autonomous motivation, goal and norm internalization, decision-making, persuasion, education, and clinical conditions such as depression and burnout. (shrink)

Einer Welt ohne letzte Gründe bleibt, so scheint es, nur die Alternative zwischen Fundamentalismus und pragmatischer Indifferenz. Beides wird weder der Komplexität noch der ungebrochenen Notwendigkeit der Begründungssuche gerecht. Die Autoren denken Begründung konsequent als ein stets prekäres Unternehmen: Den Ungründen in Philosophie und Kunst nachzugehen meint nicht eine bloße Ablehnung von Gründen oder einen existenziell aufgeladenen Nihilismus. Im Unheimlichen, Unbegrifflichen oder Unbestimmten schwingt der Versuch (wie das Scheitern) der Entbergung, Konzeptionalisierung und Bestimmung immer mit. Genauso zeichnen sich Ungründe dadurch (...) aus, dass das Negierte als Negiertes stets mitgeführt wird und wirksam bleibt. Ungründe sind immer noch Gründe - aber es sind prekäre, prozessuale, endliche Gründe, die den Anspruch, einen "guten Grund" zu liefern, auf je spezifische Weise einlösen. (shrink)

Name der Zeitschrift: Kant-Studien Jahrgang: 105 Heft: 3 Seiten: 406-417.

Psychological measurement has received strong criticism throughout the history of psychological science. Nevertheless, measurements of attributes such as emotions or intelligence continue to be widely used in research and society. I address this puzzle by presenting a new causal perspective to psychological measurement. I start with assumptions that both critics and proponents of psychological measurement are likely to accept: a minimal causal condition and the observation that most psychological concepts are ill-defined or ambiguous. Based on this, I argue that psychological (...) measurement is fundamentally different from measurement in the physical sciences but can nevertheless be useful. (shrink)

Social enterprises, like almost all organizations, continuously strive for external legitimacy. To be perceived as externally legitimated by society, social enterprises often engage in strategic partnerships. However, scholars have only recently turned their attention to the legitimating function of such partnerships. The purpose of this article is to address the hitherto neglected construct of inter-partner legitimacy. Drawing on institutional theory, we hypothesize that such inter-partner legitimacy affects the resource transfer among partners, which will, in turn, be recognized by society and (...) will subsequently affect each partner’s external legitimacy. Dyadic data of 121 strategic partnerships between social enterprises and their key partners confirm our hypotheses. We add to institutional theory by integrating the often ignored dimension of inter-partner legitimacy into our analysis and demonstrate its relevance to each partner’s external legitimacy and to resource transfer. Further contributions to the literature on institutional theory, legitimacy, social entrepreneurship, and inter-organizational relationships are identified. (shrink)

Several attempts have been done to distinguish “positive” information in an arbitrary first order theory, i.e., to find a well behaved class of closed sets among the definable sets. In many cases, a definable set is said to be closed if its conjugates are sufficiently distinct from each other. Each such definition yields a class of theories, namely those where all definable sets are constructible, i.e., boolean combinations of closed sets. Here are some examples, ordered by strength:Weak normality describes a (...) rather small class of theories which are well understood by now (see, for example, [P]). On the other hand, normalization is so weak that all theories, in a suitable context, are normalizable (see [HH]). Thus equational theories form an interesting intermediate class of theories. Little work has been done so far. The original work of Srour [S1, S2, S3] adopts a point of view that is closer to universal algebra than to stability theory. The fundamental definitions and model theoretic properties can be found in [PS], though some easy observations are missing there. Hrushovski's example of a stable non-equational theory, the first and only one so far, is described in the unfortunately unpublished manuscript [HS]. In fact, it is an expansion of the free pseudospace constructed independently by Baudisch and Pillay in [BP] as an example of a strictly 2-ample theory. Strong equationality, defined in [Hr], is also investigated in [HS]. (shrink)

I provide a sympathetic reconstruction of Kant’s motivation for endorsing incompatibilism about human freedom. On my interpretation, Kant holds that if all the determining grounds of our actions were subject to natural necessity, we would never be free to respect or defy laws of practical reason, and for Kant such freedom is a condition for the possibility that our actions are governed by categorical imperatives. I argue that his view rests on a gripping construal of the rational imperfection that afflicts (...) the human will. (shrink)

I examine how Kant argues for the transcendental ideality of space. I defend a reading on which Kant accepts the ideality of space because it explains our (actual) knowledge that mathematical judgments are necessarily true. I argue that this reading is preferable over the alternative suggestion that Kant can infer the ideality of space directly from the fact that we have an a priori intuition of space. Moreover, I argue that the reading I propose does not commit Kant to incoherent (...) modal views. If we carefully distinguish between different senses of modality, the fact that our spatial form of intuition is (in some sense) contingent does not undermine the claim that this form can explain how our mathematical judgments are (in some sense) necessary. (shrink)

Work has always been a significant source of ethical questions, philosophical reflection, and political struggle. Although the future of work in a sense is always at stake, the issue is particularly relevant right now, in light of the advent of advanced AI systems and the collective experience of the COVID-19 pandemic. This has reinvigorated philosophical discussion and interest in the study of the future of work. The purpose of this survey article is to provide an overview of the emerging philosophical (...) field that engages with the future of work, with a special focus on equality and justice, and to outline a research agenda that can help the field to develop further. Section 2 provides some historical context for the current surge in interest in the topic. Then, we discuss what work is and whether there is a philosophy of work (Section 3). The four main sub-debates we then turn to concern the value of work (Section 4), distributive justice and work (Section 5), productive justice (Section 6), and institutional reforms prompted by changes in how work is organized (Section 7). The final section discusses the importance of the distinction between ideal and non-ideal theory in philosophical investigations into the future of work. (shrink)

The aim to develop authentic forms of artistic lifestyle and self-expression played a formative role in the foundational period of post-punk in the late 1970s and early 1980s. The struggle for authenticity during that period was complicated by the artists’ growing awareness of the capitalist economy’s ability to coopt and assimilate the ideal of an authentic counter-culture, that is, to utilize this ideal for exclusively profit-oriented signing, marketing, and production strategies. In this essay, I consider what models of authenticity one (...) can glean from the early post-punk scene and whether some such model might yield a viable ideal of authenticity that is resilient against the threat of inauthentic mainstream cooption: an ideal that can, perhaps, inspire the ongoing contemporary struggle for authenticity. (shrink)

In this comment, I first point out some problems in McCauley's defense of the traditional conception of general analytical levels. Then I present certain reductionist arguments against explanatory pluralism that are not based on the New Wave model of intertheoretic reduction, against which McCauley is arguing. Reductionists that are not committed to this model might not have problems incorporating research on long-term diachronic processes in their analyses. In the last part of the paper, I briefly compare Robert N. McCauley's conception (...) of reduction to some other current accounts, highlighting the differences between them. (shrink)

In the paper the fragment transmitted by Ausonius and ascribed to Quintus Cicero on the signs of the zodiac is analysed in terms of language, transmission history and intertextuality. As a result, authorship by Q. Cicero must be regarded with great scepticism.

Religion, Metaphysik und Theologie sind durch das neuzeitliche Denken in besonderer Weise herausgefordert. Die Beiträge des Bandes befassen sich von verschiedenen Standpunkten aus mit der Spannung, die in Moderne und Postmoderne zwischen diesen Disziplinen entsteht.

Some major figures of early (1977-1984) Post-Punk, such as Joy Divison’s Ian Curtis or The Fall’s Mark E. Smith, were strongly influenced by existentialist themes they encountered in the writings of philosophers such as Camus or Nietzsche. Central among these themes is the modern struggle with nihilism. Nietzsche (at times) felt hopeful that some of us still possess the strength to see our modern disorientation as a creative opportunity and to (eventually) overcome the threat of nihilism: in this vein he (...) declares that when "we hear the news that ‘the old god is dead’” it is “as if a new dawn shone on us." By contrast, I argue that foundational Post-Punk artists express a post-Nietzschean, 20th century stance of succumbing to nihilism, an overwhelming experience of defeat and self-disgust. They write and sing from a profound sense that the modern degeneration diagnosed by Nietzsche has now reached unprecedented lows so that our “disgust at life”, our “exhaustion and… wish for the ‘end’…for being otherwise, being elsewhere” has become wholly inescapable. Nietzsche's new dawn has faded. (shrink)

This essay is an attempt to interpret the behaviour of K. in Kafka's novel "Das Schloß". The focus is on three episodes that stand, respectively, at the beginning, the middle, and the end of the novel. In all of these episodes, the concepts of 'struggle' and 'victory' play a crucial role. By paying attention to the usage of these concepts, the passages under investigation can be shown to be interrelated in a significant way. Making these connections explicit allows one to (...) draw some far-reaching conclusions about K.'s personality. (shrink)

The article examines the relationship between Aby Warburg and his library by analysing the media which is involved: first, the arrangement of the books according to the library’s principle of the ‘law of thse good neighbour’, which helps to order the books on the shelves. Second, the handling of the library is even more determined by Aby Warburg’s use of index cards and card indexes. Like his card index which is situated between him and the library, Aby Warburg himself is (...) in between two library paradigms: on the one hand, as a person of the nineteenth century, Warburg belongs to the supporters of the systematic shelving instead of cataloguing the book collection. On the other hand his work is based on swift associations and direct responses to research questions, the associations not only thought up by words, but also visually, manually to be re-arranged on the shelves, which turns out to be a rather clumsy practice. The motor and initiator of these new orders is the card index with its mobile elements, allowing quick connections between the entities and resulting in enormous processes of re-shuffling of whole shelves and systematic arrangements in the book collection. It is especially the combination of these usually incompatible paradigms that makes the Kulturwissenschaftliche Bibliothek Warburg such a unique institution and rich example of knowledge practices in the twentieth century. (shrink)

This ‘technical memoir’ shares insider knowledge of a specific scholarly and scientific situation in the second half of the 1990s: how a group of students and researchers at Humboldt-University Berlin, together with their teacher, media historian Friedrich Kittler, combined historical questions with computer science. The discussions and projects developed in this circle constituted a scholarly practice which would be called today digital humanities.

Focusing on a subject the author has extensively engaged with over the years, the article develops the notion of service as a cultural technique, and the media-theoretical figure of the servant as its servomechanism. The analysis follows three distinct scenarios that highlight, via different channels of perception, the interplay between corporeal practices and media objects in the production of specific cultural effects. In each of the examples chosen, service implies highly regulated networks of recursive operational chains that regulate in their (...) turn the production and distribution of power and knowledge. Thus, Krajewski argues, despite, or rather, precisely because of their apparent marginality and invisibility, the ‘small gestures’ of service join the ranks of already established, elementary symbolic techniques such as reading or writing. (shrink)

Wiggins and Wilbanks (2019) provide an overview of what they consider to be different models of citizen science in health and biomedical research and highlight related ethical issues. They offer, h...

We propose that rapid eye movement (REM) and slow-wave sleep contribute differently to the formation of episodic memories. REM sleep is important for building up invariant object representations that eventually recur to gamma-band oscillations in the neocortex. In contrast, slow-wave sleep is more directly involved in the consolidation of episodic memories through replay of sequential neural activity in hippocampal place cells.

In the current theoretical discourse, human dignity as it is enshrined in the German Basic Law, is often interpreted as a special „right to non-instrumentalization“ which overturns any other human right. This interpretation usually refers to Kant’s concept of human dignity, according to which any person is an “end-in-itself”. By discussing the different possibilities on how to understand this idea, I want to point out that none of possible interpretations of Kant’s concept can give good reasons for an understanding of (...) human dignity as a special “right to non-instrumentalization”. Instead I propose to understand human dignity as the principle of and the reason for the absolute inviolability of basic human rights. (shrink)