The mechanisms by which bacteria adapt to changes in their environment involve transcriptional regulation in which a transcriptional regulator responds to signal(s) from the environment and regulates (positively or negatively) the expression of several genes or operons. Some of these regulators exert a positive feedback on their own expression. This is a necessary (although not sufficient) condition for the occurrence of multistationarity. One biological consequence of multistationarity may be epigenetic modifications, a hypothesis unusual to microbiologists, in spite of some well-known (...) epigenetic modifications in bacteria. We propose here that the occurrence of mucoidy in the opportunistic pathogen Pseudomonas aeruginosa, which is currently attributed to mutations only, may also be an epigenetic modification. A theoretical approach using a generalised logical analysis lends credit to this hypothesis and suggests experiments to ascertain it. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Klossowski, Deleuze, and OrthodoxyEleanor Kaufman (bio)Among the many strange and wonderful things to be found there, Pierre Klossowski's oeuvre is a preeminent illustration of what divides univocity and equivocity and therefore serves as one of the twentieth century's most instructive models for thinking the complexity of the dialectic. Univocity and equivocity are significant both in their roots in Scholastic philosophy, as the idea that Being is expressed in (...) either one or several senses, and as belonging to a longstanding framework that helps demarcate the differences, nuanced yet significant, among members of the extraordinary generation of French intellectuals of which Klossowski was a part. Thus, these terms, apart from their theological and philosophical import, will serve as a heuristic for renarrating points of filiation and divergence among a series of prominent French thinkers, primarily Bataille, Klossowski, and Deleuze, but also extending backward to Sartre and forward to Badiou to frame the series. I will approach this in segmented fashion, first opposing Bataille's dialectic of transgression to Klossowski's more univocal method of disjunctive synthesis. When juxtaposed with Deleuze's Spinozist affirmation of univocity, however, Klossowski would seem to be more on the side of the equivocal. Whereas Deleuze criticizes the realm between the univocal and the equivocal as the lukewarm space of the analogical, my contention is that this middle realm allows for a space of movement and reversal that escapes the pitfalls Deleuze locates in the dialectic, and does so without a strict adherence to Spinozist univocity. Whereas Bataille and Deleuze remain closer to Klossowski in the tenor of their thought, I will nonetheless suggest in conclusion that Sartre and Badiou are actually closer to Klossowski on a formal level, in that each poses a similarly analogical challenge to the thought of the dialectic.For many reasons Bataille and Klossowski can be paired together. They were contemporaries, both born around the turn of the century, both writing in a variety of literary and philosophical genres, including pornographic or semi-pornographic fiction, and working outside the academy. Both wrote studies of Nietzsche, of Sade, and radical economic treatises. They were friends and fellow members in the late 1930s of the College of Sociology, which was modeled after a secret society, the members taking great interest in such topics as sacrifice and headlessness. Bataille and Klossowski wrote about each other. Both were at different points obsessed with Roman Catholicism, both at different points prepared to enter monastic orders, both in different fashions fell away. As might easily be imagined, their fiction is an outrageous mixture of the sacred and the profane, including sexual encounters and other desecrations staged at church alters and the like. Both work in that realm where pornography and theology come together. Yet while the more familiar Bataille uses pornography toward transgressive aims, the lesser-known Klossowski uses a more nuanced and interesting mechanism of boredom to elaborate an intrinsically disjunctive structure.Even boredom, for Bataille, partakes of the transgressive. In his novella The Story of the Eye, the narrator describes offhandedly how he and his companion Simone have just found their friend Marcelle's body. She has hung herself. The narrator and Simone [End Page 47] take the body down and have sex for the first time next to it. Then the narrator describes the boredom that ensues even in the face of death: "We were perfectly calm, all three of us, and that was the most hopeless part of it. Any boredom in the world is linked, for me, to that moment and, above all, to an obstacle as ridiculous as death. But that won't prevent me from thinking back to that time with no revulsion and even with a sense of complicity. Basically, the lack of excitement made everything far more absurd, and thus Marcelle was closer to me dead than in her lifetime, inasmuch as absurd existence, so I imagine, has all the prerogatives" [59–60]. This is actually an unusually meditative moment in Bataille's story of murder, priests, bullfights, and constant sex.1 Here his narrator links boredom to death, and to a reflection on the absurd boundary between life and death. But by commenting on boredom... (shrink)

Aron Gurwitsch wants to introduce a theory of organization developed by Gestalt psychology into Husserlian phenomenology. The problem is to show how it is possible to introduce a theory developed within a positive science into philosophical phenomenology. His solution is to show that aspects of this theory already are or can be phenomenological through what he calls an incipient phenomenological reduction. Specifically, it is the dismissal of the constancy hypothesis in which he identifies the possibility moving from an explanatory science (...) to a descriptive one. If the temptation can be resisted of returning to an explanatory approach and description can be radicalized, Gurwitsch believes that this reduction can become phenomenological and even attain transcendental levels. This possibility of reduction makes it possible for scientists, especially psychologists, to have a firsthand understanding of phenomenology, perhaps to convince them of this approach and realize the continuity of philosophy and the sciences and the need to maintain cooperation via phenomenology. (shrink)

John Dewey and Ludwig Wittgenstein offer devastating critiques of the dominant model of human action that each inherited in their own time. Dewey, very early in his philosophical career, ostensibly put the stimulus–response mechanical understanding of action to rest with his “reflex-arc” concept article. Wittgenstein famously redescribed action as moves within language games that interconnect to constitute an interpretively open-ended form of life. In each case, these fundamental insights serve as heuristics, guiding our intellectual activity with regard to understanding our (...) practices, and as reminders in approaching problems. Several scholars have interpreted Dewey and Wittgenstein as allies in a grand project of... (shrink)

The main objective of this work is to contribute to the literature on memory in post-conflict societies by considering how the choice of an official language is entangled in memory politics. Particularly, in Timor-Leste, the choice of Portuguese as the official language reflects an effort to create a narrative of the heroism of the ‘Generation of 75’ whilst silencing the efforts and memories of the ‘Geração Foun’ (young generation)’ during the fight for independence. Therefore, in the constituency of the new (...) state, language plays a crucial role in post-conflict efforts to (re) establish political foundations for the state and define how individuals will be remembered. This paper analyses the case of Timor-Leste and disputes over the choice of an official language after the re-establishment of independence in 2002. (shrink)

In this article, I will discuss Aron Gurwitsch's criticism of Edmund Husserl's theory of hyletic data. First, Husserl’s doctrine will be summarized in its earliest complete formulation. It will then be seen that Gurwitsch's problem with this doctrine is primarily due to his acceptance of gestalt theoretic organization. He conceives of hyletic data as being a kind of formless stuff that undergoes organiza-tion by morphetic components of the noesis, which represents a dualism in percep-tion. Instead, Gurwitsch wants to show us (...) that the organization of these contents is autochthonous. I will consider Gurwitsch's criticism against Husserl's own writings, and especially those that were not available to Gurwitsch. It will be seen that Husserl continues to develop this doctrine and that it very interestingly undergoes a kind of noematization and exhibits certain displays of autochthonous organization that in the end are not far from Gurwitsch's own conception of these affairs.Este artículo versará sobre la crítica de Aron Gurwitsch de los data hylé-ticos de Edmund Husserl. En primer lugar, se resumirá la doctrina de Husserl en su primera formulación completa. A continuación, se verá que el problema de Gur-witsch con esta doctrina se debe principalmente a su aceptación de la organización teórica de la Gestalt. Él concibe los data hyléticos como una especie de material amorfo que se somete a organización por los componentes de morphé de la noesis, lo que representa un dualismo en la percepción. En cambio, Gurwitsch quiere mos-trarnos que la organización de estos contenidos es autóctona. Se examinará la críti-ca de Gurwitsch acerca de los escritos del propio Husserl y especialmente de aque-llos que no estuvieron al alcance de Gurwitsch. Se verá que Husserl sigue desarro-llando esta doctrina y que curiosamente sufre una especie de noematización y muestra ciertas manifestaciones de organización autóctona que, a la postre, no están lejos de la concepción gurwitscheana de estos asuntos. (shrink)

The AAR-SBL Women’s Caucus session on ‘Beyond Down and Dirty: From Good to Great Sex’ revisited the Good Sex: Feminist Perspectives from the World’s Religions project and book with the participation of two of its co-editors, Mary E. Hunt and Patricia Beattie Jung, and co-author and collaborator, Wanda Defeilt. Scholar colleagues, Brandy Daniels, Fitri Junoes, and Alicia Besa Panganiban, presented intriguing papers on feminist religious and ethical reflections on what constitutes great sex as they examined the issues discussed by feminist (...) scholars and activist authors of Good Sex. Moreover, the session was an exhilarating dialogue of international, interreligious, and intergenerational perspectives on what women think is great sex. It was an exciting starting ground for intergenerational discussion with senior scholars, associated with the Good Sex book, providing generous, constructive, and well-considered responses to the presentations of their colleagues. The diverse international audience of masters, doctoral and senior scholars – male and female – was included in the complex, fun, and challenging discussion of sex. Amidst various issues raised, there was a consensus that discussions on great sex must address issues of safety, justice, and pleasure. Overall the session was a success as the platform for the presentations modelled a feminist method that was intentionally designed to give more time for discussion, not only among panelists but also with the audience. (shrink)

Children's understanding of the human mind has been found to be related to many social and experiential factors such as interactions with peers (Astington & Jenkins, 1995), parental socioeconomic a...

This is a review article (15,000 words) of Putnam's Naturalism, Realism, and Normativity, (Harvard, 2016).

ABSTRACT The fact of pluralism has set a number of practical and theoretical problems for political theorists. One of the most serious difficulties is the question of the criteria for judgment. What critical standards are available when encountering a society's practices that are different from one's own? One strategy for dealing with this is to separate out questions of ethics from questions of morality. We argue that this is a particularly unfruitful conceptual strategy. Rather our position is that the concept (...) of real interests is already operant within the practices of judgment that constitute a community, or a form of life. Our strategy is to first explore the possibility of immanent normative critique of interests expressed in forms of life using Wittgenstein and Dewey in light of Rahel Jaeggi's Critique of Forms of Life. Properly understanding how these standards of immanent critique work dissolves the problem of how to apply these to external contexts. While Jaeggi's is an excellent contribution to the discourse on critique and justification, we find that there are commitments in her idea of “immanent critique” that require reformulation with respect to the question of real interests. (shrink)

Do people have free will, or this universal belief an illusion? If free will is more than an illusion, what kind of free will do people have? How can free will influence behavior? Can free will be studied, verified, and understood scientifically? How and why might a sense of free will have evolved? These are a few of the questions this book attempts to answer. People generally act as though they believe in their own free will: they don't feel like (...) automatons, and they don't treat one another as they might treat robots. While acknowledging many constraints and influences on behavior, people nonetheless act as if they (and their neighbors) are largely in control of many if not most of the decisions they make. Belief in free will also underpins the sense that people are responsible for their actions. Psychological explanations of behavior rarely mention free will as a factor, however. Can psychological science find room for free will? How do leading psychologists conceptualize free will, and what role do they believe free will plays in shaping behavior? In recent years a number of psychologists have tried to solve one or more of the puzzles surrounding free will. This book looks both at recent experimental and theoretical work directly related to free will and at ways leading psychologists from all branches of psychology deal with the philosophical problems long associated with the question of free will, such as the relationship between determinism and free will and the importance of consciousness in free will. It also includes commentaries by leading philosophers on what psychologists can contribute to long-running philosophical struggles with this most distinctly human belief. These essays should be of interest not only to social scientists, but to intelligent and thoughtful readers everywhere. (shrink)

Nielsen Busch and Mjaaland (2023) argue that controlled donation after circulatory death does not violate the dead donor rule because the dead donor rule “merely requires that procurement of organs...

Managers vs. Owners: The Struggle for Corporate Control in American Democracy deals with a subject of profound importance: understanding the place of the modern corporation in a democratic society. This latest volume in the acclaimed Ruffin Series in Business Ethics describes how the balance between corporate power and government regulation has changed with the interests of society as a whole. The first section examines the debates over the rules that individuals or organized groups would agree to follow in their interactions (...) to accrue social advantages. The second section looks at management's point of view and tells how law promotes the need for managerial collective action and provides a vocabulary for articulating management as a profession. The authors conclude by looking at the impact of collective investor action - especially institutional investors - on the efforts by managers to preserve their autonomy. This examination of the inherent conflicts between the interests of corporate owners, the interests of the larger society, and the interests of managers who run corporations will be essential reading for students, scholars, and professionals concerned with the place of the large corporation in a democratic society. (shrink)

Deprivation offers a plausible explanation for the badness of death, so fear is not unreasonable. But horror at the prospect of one's death is not just extreme fear because horror is structurally different than fear. Horror requires a different explanation. For Sartre, horror is possible only in unique circumstances. I argue that Sartre's view, when combined with the subjective incomprehensibility of one's annihilation, can explain horror and other negative emotions that are not contingent on deprivation. Further, I argue that while (...) fear can be reasonable if one's death will deprive, Lucretius's Symmetry Argument shows that horror is unreasonable. (shrink)

The problem of punishment -- Punishment as crime prevention -- Can retributive punishment be justified? -- The mixed theory of punishment -- Retribution and revenge -- What is the purpose of retribution? -- Making sense of honor -- Is punishment justified?

Background A biobank is a structure which collects and manages biological samples and their associated data. The collected samples will then be made available for various uses. The sharing of those samples raised ethical questions which have been answered through specific rules. Thus, a Biobank functioning under tight ethical rules would be immensely valuable from a scientific and an economic view point. In 2009, Côte d’Ivoire established a biobank, which has been chosen to house the regional biobank of Economic Community (...) of West African States countries in 2018. To ensure optimal and efficient use of this biobank, the scientific community must be aware of its existence and its role. It was therefore necessary to evaluate the knowledge of laboratories staff on the role and activities of a biobank. Methods This descriptive study was done by questioning staff from laboratories working on human’s health, animals or plants. The laboratories were located in southern Côte d’Ivoire. Results A total of 205 people completed the questionnaire. Of these 205 people, 34.63% were biologists, 7.32% engineers, 48.78% technicians and 9.27% PhD students. The average length of work experience was 10.11 ± 7.83 years. In this study, 43.41% of the participants had never heard of biobanking. Only 48.78% of participants had a good understanding of the role of a biobank. Technicians and PhD students were less educated on the notion of biobank. Conclusion The level of knowledge of laboratory staff about biobanking needs to be improved. Training on the role, activities and interests of the biobank is important. (shrink)

This concluding essay offers reflections on core components of the faculty fellowship program, its outcomes and results, and program design and administration. Amid the current calls for reform in legal and other professional education, the lessons we learned and perspectives we gained during this fellowship program may be relevant to any faculty members and university administrations that are seeking to create more effective and engaged professional and graduate school programs, whatever may be their subject-matter discipline.

In this essay, I discuss philosophy's decline, in the context of disciplinization, scientism, and specialization, as well as possible ways in which it might renew itself.

In this volume, leading scholars present new and original essays to address controversies raised regarding the focus, structure and justification of the capabilities approach to equality.

The essays in this collection, written by prominent scholars, offer a new approach to their work.

Creativity is of rising interest to scholars and laypeople alike. Creativity in the arts, however, is very different from creativity in science, business, sports, cooking, or teaching. This book brings together top experts in the field from around the world to discuss creativity across many different domains. Each chapter includes clear definitions, intriguing research, potential measures, and suggestions for development or future directions. After a broad discussion of creativity across different domains, subsequent chapters look deeper into those individual domains to (...) explore how creativity varies when expressed in different ways. Ultimately, the book offers a future-looking perspective integrating the different variations of creativity across domains. (shrink)

Current discussions of “evidentialism” seem to presuppose essentially traditional theistic conceptions and formulations. For many theologians. however, these have become problematic because of (a) the rise of a new consciousness of the significance of religiouspluralism; (b) the emergence of theories about the ways in which our symbolic frames of orientation shape all our experiencing and thinking; (c) a growing awareness that significant responsibility for some of the major evils of the twentieth century must be laid to ourreligious traditions. Since recent (...) discussion of “evidentialism” continues to employ traditional symbols and concepts without sensitivity to these matters, it has not attracted much interest among contemporary theologians. (shrink)