1. v. A história da filosofia portuguesa desde o seu coméc̣o até ao final do século xvi (exceptuada a restaurac̣ão da escolástica).

Three‐dimensional structured illumination microscopy (3D‐SIM) has opened up new possibilities to study nuclear architecture at the ultrastructural level down to the ∼100 nm range. We present first results and assess the potential using 3D‐SIM in combination with 3D fluorescence in situ hybridization (3D‐FISH) for the topographical analysis of defined nuclear targets. Our study also deals with the concern that artifacts produced by FISH may counteract the gain in resolution. We address the topography of DAPI‐stained DNA in nuclei before and after (...) 3D‐FISH, nuclear pores and the lamina, chromosome territories, chromatin domains, and individual gene loci. We also look at the replication patterns of chromocenters and the topographical relationship ofXist‐RNA within the inactive X‐territory. These examples demonstrate that an appropriately adapted 3D‐FISH/3D‐SIM approach preserves key characteristics of the nuclear ultrastructure and that the gain in information obtained by 3D‐SIM yields new insights into the functional nuclear organization. (shrink)

Present day neuroscience places the brain at the centre of study. But what if researchers viewed the brain not as the foundation of life, rather as a mediating organ? Ecology of the Brain addresses this very question. It considers the human body as a collective, a living being which uses the brain to mediate interactions.

Inequality is widely regarded as morally objectionable: T. M. Scanlon investigates why it matters to us. He considers the nature and importance of equality of opportunity, whether the pursuit of greater equality involves objectionable interference with individual liberty, and whether the rich can be said to deserve their greater rewards.

Seit Beginn der frühen Neuzeit ist das naturwissenschaftliche Verfahren maßgeblich durch ein neues Konzept geprägt: das Konzept des experimentellen, gestalterischen Eingriffs in die Natur. Es geht nun nicht mehr darum, eine Geschichte der "freien und ungebundenen Natur" (Bacon) zu erzählen, die in ihrem eigenen Lauf belassen und als vollkommene Bildung betrachtet wird. Es geht vielmehr darum, der "gebundenen und bezwungenen Natur" (Bacon) vermittels der experimentellen Tätigkeit des Menschen die Geheimnisse zu entreißen. Diese technisch-praktische Konzeption grenzt sich explizit von den klassischen (...) kontemplativen Wissenschaftsvorstellungen der Antike ab. Wie es Kant paradigmatisch in Bezug auf Bacon formuliert hat, ist diese "Revolution der Denkart" maßgeblich durch ein gewandeltes Verständnis des Verhältnisses des Menschen zur Natur geprägt. Der Mensch als Experimentator hat für Kant nicht mehr die "Qualität eines Schülers", der sich passiv von der Natur belehren läßt und an ihrem "Leitbande" (Kant) gegängelt wird. Seine neu gewonnene Autorität verleiht ihm vielmehr den Status eines Richters, der nun die Natur nötigen kann, auf gestellte Fragen zu antworten. Die Laborforschung der modernen Naturwissenschaft ist von den Formen der alten Naturwissenschaft so weit entfernt, daß sie den Vorwurf auf sich zog, sie untersuche Artekakte, aber nicht Natur. Die grundlegenden Theorien über Natur können in der Regel nur unter den künstlichen Bedingungen des Labors aufgestellt werden. Daraus darf aber nicht geschlossen werden, die anhand von Laborphänomenen aufgestellten und getesteten Theorien handelten nicht von der Natur außerhalb der Labore. Aber ihrer exakten und detaillierten Anwendung auf Prozesse außerhalb der Labore stehen eine Fülle von Schwierigkeiten entgegen. Insofern markiert das Labor sehr wohl eine Grenze exakter Naturforschung, die für den Umgang der wissenschaftlich-technischen Zivilisation mit der Natur wichtige Konsequenzen hat. Inhalt: Kristian Köchy / Gregor Schiemann: Natur im Labor Lothar Schäfer: Die Erscheinung der Natur unter Laborbedingungen Holm Tetens: Das Labor als Grenze der exakten Naturforschung Christoph Rehmann-Sutter: Genes in Labs - Concepts of Development and the Standard Environment Kristian Köchy: Lebewesen im Labor. Das Experiment in der Biologie Jutta Weber: Mannigfaltige Techno-Naturen. Von epistemischen Modellsystemen und situierten Maschinen Thomas Sören Hoffmann: Gezeigte versus sich zeigende Natur. Eine Skizze im Blick auf das Verhältnis von Labor und Natur Klaus Michael Meyer-Abich: Laborforschung im Erkenntnishandeln der Experimentiergesellschaft. Eine holistisch-pragmatische Perspektive für die Wissenschaftstheorie. (shrink)

Marr's levels of analysis—computational, algorithmic, and implementation—have served cognitive science well over the last 30 years. But the recent increase in the popularity of the computational level raises a new challenge: How do we begin to relate models at different levels of analysis? We propose that it is possible to define levels of analysis that lie between the computational and the algorithmic, providing a way to build a bridge between computational- and algorithmic-level models. The key idea is to push the (...) notion of rationality, often used in defining computational-level models, deeper toward the algorithmic level. We offer a simple recipe for reverse-engineering the mind's cognitive strategies by deriving optimal algorithms for a series of increasingly more realistic abstract computational architectures, which we call “resource-rational analysis.”. (shrink)

It is notoriously difficult to find an intuitively satisfactory rule for evaluating populations based on the welfare of the people in them. Standard examples, like total utilitarianism, either entail the Repugnant Conclusion or in some other way contradict common intuitions about the relative value of populations. Several philosophers have presented formal arguments that seem to show that this happens of necessity: our core intuitions stand in contradiction. This paper assesses the state of play, focusing on the most powerful of these (...) ‘impossibility theorems’, as developed by Gustaf Arrhenius. I highlight two ways in which these theorems fall short of their goal: some appeal to a supposedly egalitarian condition which, however, does not properly reflect egalitarian intuitions; the others rely on a background assumption about the structure of welfare which cannot be taken for granted. Nonetheless, the theorems remain important: they give insight into the difficulty, if not perhaps the impossibility, of constructing a satisfactory population axiology. We should aim for reflective equilibrium between intuitions and more theoretical considerations. I conclude by highlighting one possible ingredient in this equilibrium, which, I argue, leaves open a still wider range of acceptable theories: the possibility of vague or otherwise indeterminate value relations. (shrink)

We present a formal, mathematical model of argument structure and evaluation, taking seriously the procedural and dialogical aspects of argumentation. The model applies proof standards to determine the acceptability of statements on an issue-by-issue basis. The model uses different types of premises (ordinary premises, assumptions and exceptions) and information about the dialectical status of statements (stated, questioned, accepted or rejected) to allow the burden of proof to be allocated to the proponent or the respondent, as appropriate, for each premise separately. (...) Our approach allows the burden of proof for a premise to be assigned to a different party than the one who has the burden of proving the conclusion of the argument, and also to change the burden of proof or applicable proof standard as the dialogue progresses from stage to stage. Useful for modeling legal dialogues, the burden of production and burden of persuasion can be handled separately, with a different responsible party and applicable proof standard for each. Carneades enables critical questions of argumentation schemes to be modeled as additional premises, using premise types to capture the varying effect on the burden of proof of different kinds of questions. (shrink)

The reaction to Darwin's Origin of Species varied in many countries according to the roles played by national scientific institutions and traditions and the attitudes of religious and political groups. The contributors to this volume, including M. J. S. Hodge, David Hull, and Roberto Moreno, gathered in 1972 at an international conference on the comparative reception of Darwinism. Their essays look at early pro- and anti-Darwinism arguments, and three additional comparative essays and appendices add a larger perspective. For this paperback (...) edition, Thomas F. Glick has added a new preface commenting on recent research. (shrink)

While Bayesian models have been applied to an impressive range of cognitive phenomena, methodological challenges have been leveled concerning their role in the program of rational analysis. The focus of the current article is on computational impediments to probabilistic inference and related puzzles about empirical confirmation of these models. The proposal is to rethink the role of Bayesian methods in rational analysis, to adopt an independently motivated notion of rationality appropriate for computationally bounded agents, and to explore broad conditions under (...) which Bayesian agents would be rational. The proposal is illustrated with a characterization of costs inspired by thermodynamics. (shrink)

Languages are transmitted from person to person and generation to generation via a process of iterated learning: people learn a language from other people who once learned that language themselves. We analyze the consequences of iterated learning for learning algorithms based on the principles of Bayesian inference, assuming that learners compute a posterior distribution over languages by combining a prior (representing their inductive biases) with the evidence provided by linguistic data. We show that when learners sample languages from this posterior (...) distribution, iterated learning converges to a distribution over languages that is determined entirely by the prior. Under these conditions, iterated learning is a form of Gibbs sampling, a widely-used Markov chain Monte Carlo algorithm. The consequences of iterated learning are more complicated when learners choose the language with maximum posterior probability, being affected by both the prior of the learners and the amount of information transmitted between generations. We show that in this case, iterated learning corresponds to another statistical inference algorithm, a variant of the expectation-maximization (EM) algorithm. These results clarify the role of iterated learning in explanations of linguistic universals and provide a formal connection between constraints on language acquisition and the languages that come to be spoken, suggesting that information transmitted via iterated learning will ultimately come to mirror the minds of the learners. (shrink)

Émile Durkheim zählt zu den Klassikern der Soziologie. Der Band greift erstmals unbekannte Rezeptionslinien Durkheims auf und zeigt ihn so in all seiner Komplexität und Aktualität: als Vorreiter einer transdisziplinären Sozialwissenschaft, als scharfsinnigen Theoretiker, als Denker des Materiellen und des Symbolischen. Neben ihm kommen auch seine Kollegen, Erben und zeitgenössischen Kritiker in den Blick. Dabei wird deutlich, dass Durkheims Werk nicht nur die Soziologie prägte, sondern auch der Ethnologie und der Philosophie grundlegende Impulse gab. Mit Beiträgen von Stéphane Baciocchi, Stefan (...) Beck, Tanja Bogusz, Heike Delitz, Emmanuel Désveaux, Jean-Louis Fabiani, Joachim Fischer, Marcel Fournier, Bruno Karsenti, Frédéric Keck, Wiebke Keim, Steven Lukes, Stephan Moebius, Lothar Peter, Devyani Prabhat, Anne W. Rawls, Thomas Scheffer, Michael Schillmeier, Robert Seyfert, Susan Stedman Jones und Jean Terrier. (shrink)

In a recent paper Weinberg (2007) claims that there is an essential mark of trustworthiness which typical sources of evidence as perception or memory have, but philosophical intuitions lack, namely that we are able to detect and correct errors produced by these “hopeful” sources. In my paper I will argue that being a hopeful source isn't necessary for providing us with evidence. I then will show that, given some plausible background assumptions, intuitions at least come close to being hopeful, if (...) they are reliable. If this is true, Weinberg's new challenge comes down to the claim that philosophical intuitions are not reliable since they are significantly unstable. In the second part of my paper I will argue that and why the experimentally established instability of folk intuitions about philosophical cases does not show that philosopher's expert intuitions about these cases are instable. (shrink)

In philosophy, as in many other disciplines and domains, stable disagreement among peers is a widespread and well-known phenomenon. Our intuitions about paradigm cases, e.g. Christensen's Restaurant Case, suggest that in such controversies suspension of judgment is rationally required. This would prima facie suggest a robust suspension of judgment in philosophy. But we are still lacking a deeper theoretical explanation of why and under what conditions suspension is rationally mandatory. In the first part of this paper I will focus on (...) this question. After a critical survey of some recent alternative approaches (diversity as a thread to the reliability, decision problem, acquisition of undercutting defeaters), I will argue that in fact discovering disagreement with an opponent provides me with a rebutting defeater, but only if some further non-trivial conditions are satisfied - among them my acknowledging her as my reliability peer. In the second part of the paper I will explore in more detail the skeptical implications this account has for philosophy. Here, I will defend two claims. First, skepticism about philosophy is mandatory only if the relevant peerness assumption can be justified. Second, in philosophy there is no basis available that would support the relevant peerness assumption. If this is correct, we are not forced into skepticism about philosophy and may rationally retain our philosophical beliefs even in the face of controversy. (shrink)

Codes of ethics are directly aimed at behavioral control, but they also affect a company’s ethical culture, which in turn concerns compliance and ethical behavior. To positively influence a company’s ethical culture, employees must be familiar with its code of ethics, perceive that top management is committed to the code, and believe that their peers also comply with the code. The evidence on whether a code’s design affects a company’s ethical culture is limited. This study’s factorial survey experiment contributes to (...) this gap in two ways: first, it investigates whether a code’s design affects how easily the code can be learned and, therefore, contributes to code familiarity. Second, it examines how a code can convey expectations regarding top management’s commitment and peers’ behavior, both of which are part of ethical culture. The results indicate that a positive tone increases code familiarity, and a code signed by top managers sends a strong signal of their commitment to the code. Finally, various implications of the results for research and practice are discussed. (shrink)

This paper accomplishes two goals. First, I elucidate Edmund Husserl’s theory of inauthentic judgments from his 1890 “On the Logic of Signs.” It will be shown how inauthentic judgments are distinct from other signitive experiences, in such a manner that when Husserl seeks to account for them, he is forced to revise the general structure of his philosophy of meaning and in doing so, is also able to realize novel insights concerning the nature of signification. Second, these conclusions are revealed (...) to be the foundation of Husserl’s pure logical grammar, found in the 1901 “Fourth Logical Investigation.” In his analysis of inauthentic judgments, Husserl already recognized, albeit in a problematic way and for entirely different reasons, many of the central tenets of the 1901 work concerning categoremata and syncategoremata, matter and form, and the isomorphism between them. (shrink)

Descriptions of Gettier cases can be interpreted in ways that are incompatible with the standard judgment that they are cases of justified true belief without knowledge. Timothy Williamson claims that this problem cannot be avoided by adding further stipulations to the case descriptions. To the contrary, we argue that there is a fairly simple way to amend the Ford case, a standard description of a Gettier case, in such a manner that all deviant interpretations are ruled out. This removes one (...) major objection to interpreting our judgments about Gettier cases as strict conditionals. (shrink)

This paper presents a new approach to the class-theoretic paradoxes. In the first part of the paper, I will distinguish classes from sets, describe the function of class talk, and present several reasons for postulating type-free classes. This involves applications to the problem of unrestricted quantification, reduction of properties, natural language semantics, and the epistemology of mathematics. In the second part of the paper, I will present some axioms for type-free classes. My approach is loosely based on the Gödel–Russell idea (...) of limited ranges of significance. It is shown how to derive the second-order Dedekind–Peano axioms within that theory. I conclude by discussing whether the theory can be used as a solution to the problem of unrestricted quantification. In an appendix, I prove the consistency of the class theory relative to Zermelo–Fraenkel set theory. (shrink)

People are adept at inferring novel causal relations, even from only a few observations. Prior knowledge about the probability of encountering causal relations of various types and the nature of the mechanisms relating causes and effects plays a crucial role in these inferences. We test a formal account of how this knowledge can be used and acquired, based on analyzing causal induction as Bayesian inference. Five studies explored the predictions of this account with adults and 4-year-olds, using tasks in which (...) participants learned about the causal properties of a set of objects. The studies varied the two factors that our Bayesian approach predicted should be relevant to causal induction: the prior probability with which causal relations exist, and the assumption of a deterministic or a probabilistic relation between cause and effect. Adults’ judgments (Experiments 1, 2, and 4) were in close correspondence with the quantitative predictions of the model, and children’s judgments (Experiments 3 and 5) agreed qualitatively with this account. (shrink)

Erratum to: Philos Stud DOI 10.1007/s11098-013-0226-3Dear Reader, due to production systems the following changes could not be made to this article:In the paragraph immediately preceding the case description (ford-iii), the sentenceHere we explicitly state that Smith’s inference is based only on his belief that Jones owns a Ford, and that this logical inference provides Smith’s only justification for believing that someone in his office owns a Ford (to make things fully precise, we also add a time index).should be replaced withHere (...) we explicitly state that Smith’s inference is based only on his belief that Jones owns a Ford (plus the justified background belief that Jones is in his office), and that this logical inference provides Smith’s only justification for believing that someone in his office owns a Ford (to make things fully precise, we also add a time index).The added part is highlighted in boldface.And within the case description (ford-iii), the sentenceFrom this belief alone. (shrink)

Purpose Although surrogate decision-making is prevalent in intensive care units and concerns with decision quality are well documented, little is known about how clinicians help family members understand the surrogate role. We investigated whether and how clinicians provide normative guidance to families regarding how to function as a surrogate. Subjects and methods We audiorecorded and transcribed 73 ICU family conferences in which clinicians anticipated discussing goals of care for incapacitated patients at high risk of death. We developed and applied a (...) coding framework to identify normative statements by clinicians regarding what considerations should guide surrogates’ decisions, including whether clinicians explained one or more of Buchanan and Brock’s three standard principles of SDM to family members. Results Clinicians made at least one statement about how to perform the surrogate role in 24 conferences ). We observed three general types of normative guidance provided to surrogates, with some conferences containing more than one type of guidance: counselling about one or more standard principles of SDM ; counselling surrogates to make decisions centred on the patient as a person, without specifying how to accomplish that ; and counselling surrogates to make decisions based on the family’s values. Conclusions Clinicians did not provide normative guidance about the surrogate role in two-thirds of family conferences for incapacitated patients at high risk for death. When they did, clinicians’ guidance was often incomplete and sometimes conflicted with standard principles of SDM. Future work is needed to understand whether providing explicit guidance on how to perform the surrogate role improves decision-making or mitigates surrogates’ psychological distress. (shrink)

Cognitivism about trust says that it requires belief that the trusted is trustworthy; non-cognitivism denies this. At stake is how to make sense of the strong but competing intuitions that trust is an attitude that is evaluable both morally and rationally. In proposing that one's respect for another's agency may ground one's trusting beliefs, second-personal accounts provide a way to endorse both intuitions. They focus attention on the way that, in normal situations, it is the person whom I trust. My (...) task is to develop an account of the latter insight without the controversial theoretical commitments of the former. I propose a functional account for why the second and third-personal ‘systems’ operate not just in parallel, but in tandem, in support of a cognitivist account of trust. (shrink)

This is a survey article about epistemic defeaters: what is defeated, how defeaters work, different kinds of defeaters, indefeasibility and how defeaters fit into epistemic internalism and externalism.

The paper examines the place of power in the action theories of Francisco Suarez and Thomas Hobbes. Power is the capacity to produce or determine outcomes. Two cases of power are examined. The first is freedom or the power of agents to determine for themselves what they do. The second is motivation, which involves a power to which agents are subject, and by which they are moved to pursue a goal. Suarez, in the Metaphysical Disputations, uses Aristotelian causation to (...) model these two forms of power. Freedom is efficient causation, but in a special form that I explain as involving something that ordinary causation does not – the contingent determination of outcomes. Motivating power is final causation, which Suarez characterizes as the power of a goal or end to move us to attain it through its goodness or desirability. Suarez regards these two forms of power as consistent – we can be moved by the goodness of a goal freely to determine for ourselves that we act in order to attain it. Hobbes denied the existence of all forms of power beyond ordinary causation, the power of one motion in matter to determine another. So he denied the very existence both of freedom and of any form of motivating power beyond the ordinary causal power of desires as materially based psychological states to produce actions. The goodness itself of a goal never moves us, whether to desire the goal in the first place or to act in order to attain it. The paper examines Hobbes’s arguments and their consequence – establishing the foundations for Hume’s scepticism about practical reason. (shrink)

In the first part of this paper I will characterize the specific nature of rational intuition. It will be claimed that rational intuition is an evidential state with modal content that has an a priori source. This claim will be defended against several objections. The second part of the paper deals with the so-called explanationist objection against rational intuition as a justifying source. According to the best reading of this objection, intuition cannot justify any judgment since there is no metaphysical (...) explanation of its reliability. It will be argued that in the case of intuition the very demand of such an explanation is based on a category mistake. (shrink)

After presenting the major objections raised against standard formulations of the H-D method of theory testing, I identify what seems to be an important element of truth underlying the method. I then draw upon this element in an effort to develop a plausible formulation of the H-D method which avoids the various objections.

Over the past decades, science funding shows a shift from recurrent block funding towards project funding mechanisms. However, our knowledge of how project funding arrangements influence the organizational and epistemic properties of research is limited. To study this relation, a bridge between science policy studies and science studies is necessary. Recent studies have analyzed the relation between the affordances and constraints of project grants and the epistemic properties of research. However, the potentially very different affordances and constraints of funding arrangements (...) such as awards, prizes and fellowships, have not yet been taken into account. Drawing on eight case studies of funding arrangements in high performing Dutch research groups, this study compares the institutional affordances and constraints of prizes with those of project grants and their effects on organizational and epistemic properties of research. We argue that the prize case studies diverge from project-funded research in three ways: 1) a more flexible use, and adaptation of use, of funds during the research process compared to project grants; 2) investments in the larger organization which have effects beyond the research project itself; and 3), closely related, greater deviation from epistemic and organizational standards. The increasing dominance of project funding arrangements in Western science systems is therefore argued to be problematic in light of epistemic and organizational innovation. Funding arrangements that offer funding without scholars having to submit a project-proposal remain crucial to support researchers and research groups to deviate from epistemic and organizational standards. (shrink)

Carneades is an open source argument mapping application and a programming library for building argumentation support tools. In this paper, Carneades’ support for argument reconstruction, evaluation and visualization is illustrated by modeling most of the factual and legal arguments in Popov v Hayashi.

Contemporary epistemologists typically define a priori justification as justification that is independent of sense experience. However, sense experience plays at least some role in the production of many paradigm cases of a priori justified belief. This raises the question of when experience is epistemically relevant to the justificatory status of the belief that is based on it. In this paper, I will outline the answers that can be given by the two currently dominant accounts of justification, i.e. evidentialism and reliabilism. (...) While for the evidentialist, experience is epistemically relevant only if it is used as evidence, the reliabilist requires that the reliability of the relevant process depends on the reliability of experiential processes. I will argue that the reliabilist account accommodates our pre-theoretic classifications much better. In the final part of my paper I will use the reliabilist criterion to defend the a priori—a posteriori distinction against recent challenges by Hawthorne and Williamson. (shrink)

Diese Analytische Einführung behandelt die wichtigsten Grundfragen und -probleme der Erkenntnistheorie und enthält eine ausführliche Darstellung von Positionen und Argumenten aus der gegenwärtigen Diskussion. Sie richtet sich an Studierende der Philosophie und anderer Fachgebiete, bietet aber auch für philosophische Kenner eine gewinnbringende kritische Orientierung. Für die zweite Auflage wurde der Text vollständig überarbeitet, um die jüngsten Entwicklungen im Themenfeld zu berücksichtigen. Am Ende jedes Kapitels gibt es nun Studienfragen zur selbständigen Rekapitulation und kommentierte Hinweise auf wichtige neue und weiterführende Literatur. (...) Im Anhang finden sich Vorschläge für thematisch fokussierte Lehrveranstaltungen auf der Grundlage dieses Buches. Behandelt werden u.a. die erkenntnistheoretischen Grundbegriffe sowie unterschiedliche Antworten auf die Fragen nach der Struktur, dem Umfang und den Quellen menschlichen Wissens. Die spezifischen Wissensarten kommen ausführlich zur Sprache. Ein besonderes Augenmerk liegt außerdem auf der Rolle der Erkenntnistheorie innerhalb der Philosophie sowie ihrem Verhältnis zu den Einzelwissenschaften. (shrink)