Vaccinia virus, the world's oldest vaccine, was used originally for the eradication of smallpox. It is now being genetically engineered to create new live vaccines for use against other infectious agents of medical and veterinary importance. Genes coding for antigens of several pathogens have been linked to vaccinia virus transcriptional regulatory signals and inserted into the vaccinia virus genome. The resultant recombinant viruses are infectious, express the foreign gene, stimulate specific immune responses in vaccinated animals and can protect against disease (...) caused by the corresponding pathogen. (shrink)

Le livre de Nadine Bernard n’aborde pas un sujet neuf et ne comble pas un vide bibliographique. Les synthèses anciennes, telle celle de Claude Mossé, et plus récentes, comme le premier volume de l’Histoire des femmes paru sous la direction de Pauline Schmitt-Pantel ou encore le livre récent de Pierre Brulé, ont déjà beaucoup donné au lecteur, spécialiste ou non, qui s’intéresse à ce champ d’étude. Mais ce livre fait pourtant oeuvre utile. Procédant d’une bonne connaissance de la bibliographie...

Questo breve scritto si propone di ripercorrere sinteticamente alcuni nodi fondamentali del dibattito filosofico tra Bernard Williams e Martha Nussbaum sul significato e sul valore etico della rappresentazione tragica non tanto all’interno del mondo greco quanto per la contemporaneità. Si cercherà di mostrare lo scarto tra le diverse concezioni dei due autori a partire dalle differenti interpretazioni che essi forniscono dell’Agamennone di Eschilo, e dei diversi giudizi che essi formulano nei confronti del protagonista e della sua vicenda. Gli obiettivi (...) delle argomentazioni che seguono sono principalmente due: innanzitutto evidenziare come in alcune delle critiche mosse dalla filosofa americana al collega britannico siano rinvenibili spunti fondamentali per quella che si ritiene una più completa comprensione della tragedia come caso limite del conflitto tra soggetto etico e mondo; in secondo luogo, attraverso una riproposizione del conflitto di valori in termini di conflitto di ruoli, produrre una giustificazione del giudizio di Nussbaum su Agamennone compatibile con l’approccio di Williams. (shrink)

Traditional philosophical discussions of knowledge have focused on the epistemic status of full beliefs. In this book, Moss argues that in addition to full beliefs, credences can constitute knowledge. For instance, your .4 credence that it is raining outside can constitute knowledge, in just the same way that your full beliefs can. In addition, you can know that it might be raining, and that if it is raining then it is probably cloudy, where this knowledge is not knowledge of (...) propositions, but of probabilistic contents. -/- The notion of probabilistic content introduced in this book plays a central role not only in epistemology, but in the philosophy of mind and language as well. Just as tradition holds that you believe and assert propositions, you can believe and assert probabilistic contents. Accepting that we can believe, assert, and know probabilistic contents has significant consequences for many philosophical debates, including debates about the relationship between full belief and credence, the semantics of epistemic modals and conditionals, the contents of perceptual experience, peer disagreement, pragmatic encroachment, perceptual dogmatism, and transformative experience. In addition, accepting probabilistic knowledge can help us discredit negative evaluations of female speech, explain why merely statistical evidence is insufficient for legal proof, and identify epistemic norms violated by acts of racial profiling. Hence the central theses of this book not only help us better understand the nature of our own mental states, but also help us better understand the nature of our responsibilities to each other. (shrink)

This paper develops a precise understanding of the thesis of moral encroachment, which states that the epistemic status of an opinion can depend on its moral features. In addition, I raise objections to existing accounts of moral encroachment. For instance, many accounts fail to give sufficient attention to moral encroachment on credences. Also, many accounts focus on moral features that fail to support standard analogies between pragmatic and moral encroachment. Throughout the paper, I discuss racial profiling as a case study, (...) arguing that moral encroachment can help us identify one respect in which racial profiling is epistemically problematic. (shrink)

Public health responses to the Covid‐19 pandemic included various measures to mitigate the spread of the virus. Among these, the most restrictive was a broad category referred to as “lockdowns.” We argue that the reasoning offered in favor of extended lockdowns—those lasting several months or longer—did not adequately account for a host of countervailing considerations, including the impact on mental illness, education, employment, and marginalized communities as well as health, educational, and economic inequities. Furthermore, justifications offered for extended lockdowns set (...) aside a basic tenet of public health ethics: restrictions on liberty and autonomy should be the least intrusive means of achieving the desired end. Since it is now clear that extended lockdowns cause severe harm to many vulnerable populations, the burden of proof is on those who would advocate for them, and there must be a much higher bar to implement an extended lockdown, with high‐quality evidence that the benefit would substantially exceed its harm. (shrink)

Existing discussions of legal proof address a host of apparently disparate questions: What does it take to prove a fact beyond a reasonable doubt? Why is the reasonable doubt standard notoriously elusive, sometimes considered by courts to be impossible to define? Can the standard of proof by a preponderance of the evidence be defined in terms of probability thresholds? Why is statistical evidence often insufficient to meet the burden of proof? -/- This paper defends an account of proof that addresses (...) each of these questions. Where existing theories take a piecemeal approach to these puzzles, my theory develops an insight that unifies them—namely, the thesis that legal proof requires knowledge. Although this thesis may seem radical at first, I answer several common objections to it, and I argue that it does better than several competing accounts when it comes to making sense of our intuitions about what legal proof requires. (shrink)

Pt. I. The apparent good. Evaluative cognition -- Perceiving the good -- Phantasia and the apparent good -- pt. II. The apparent good and non-rational motivation. Passions and the apparent good -- Akrasia and the apparent good -- pt. III. The apparent good and rational motivation. Phantasia and deliberation -- Happiness, virtue, and the apparent good -- Practical induction -- Conclusion : Aristotle's practical empiricism.

This paper motivates and develops a novel semantics for several epistemic expressions, including possibility modals and indicative conditionals. The semantics I defend constitutes an alternative to standard truth conditional theories, as it assigns sets of probability spaces as sentential semantic values. I argue that what my theory lacks in conservatism is made up for by its strength. In particular, my semantics accounts for the distinctive behavior of nested epistemic modals, indicative conditionals embedded under probability operators, and instances of constructive dilemma (...) containing epistemic vocabulary. (shrink)

This paper argues that just as full beliefs can constitute knowledge, so can properties of your credence distribution. The resulting notion of probabilistic knowledge helps us give a natural account of knowledge ascriptions embedding language of subjective uncertainty, and a simple diagnosis of probabilistic analogs of Gettier cases. Just like propositional knowledge, probabilistic knowledge is factive, safe, and sensitive. And it helps us build knowledge-based norms of action without accepting implausible semantic assumptions or endorsing the claim that knowledge is interest-relative.

In dynamic epistemic logic and other fields, it is natural to consider relativization as an operator taking sentences to sentences. When using the ideas and methods of dynamic logic, one would like to iterate operators. This leads to iterated relativization. We are also concerned with the transitive closure operation, due to its connection to common knowledge. We show that for three fragments of the logic of iterated relativization and transitive closure, the satisfiability problems are fi1 11–complete. Two of these fragments (...) do not include transitive closure. We also show that the question of whether a sentence in these fragments has a finite (tree) model is fi0 01–complete. These results go via reduction to problems concerning domino systems. (shrink)

This paper defends an account of full belief, including an account of its relationship to credence. Along the way, I address several familiar and difficult questions about belief. Does fully believing a proposition require having maximal confidence in it? Are rational beliefs closed under entailment, or does the preface paradox show that rational agents can believe inconsistent propositions? Does whether you believe a proposition depend partly on your practical interests? My account of belief resolves the tension between conflicting answers to (...) these questions that have been defended in the literature. In addition, my account complements fruitful probabilistic theories of assertion and knowledge. (shrink)

Keith Thomas: Gerald Edward Aylmer, 1926-2000 Adrian Hollis: William Spencer Barrett, 1914-2001 Bruce Williams: Charles Frederick Carter, 1919-2002 Malcolm Mackintosh: John Erickson, 1929-2002 J. H .R. Davis: Raymond William Firth, 1901-2002 F. M. L. Thompson: Hrothgar John Habakkuk, 1915-2002 A. W. Price: Richard Mervyn Hare, 1919-2002 Hugh Lloyd-Jones: Geoffrey Stephen Kirk, 1921-2003 Michael Lapidge and Peter Matthews: Vivien Anne Law, 1954-2002 Ann Moss: John Lough, 1913-2000 Terence Cave: Ian Dalrymple McFarlane, 1915-2002 Ludwig Paul: David Neil MacKenzie, 1926-2001 Peter Birks: (...) John Kieran Barry Moylan Nicholas, 1919-2002 Jonathan Shepard: Dimitri Dimitrievich Obolensky, 1918-2001 David Cannadine: John Harold Plumb, 1911-2001 Daniel Waley: Nicolai Rubinstein, 1911-2002 Ian Wood: John Michael Wallace-Hadrill, 1916-1985 R. G. M. Nisbet: William Smith Watt, 1913-2002 G. W. Bernard: Richard Bruce Wernham, 1906-1999. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:ContributorsMichael Bernard-Donals is the Nancy Hoefs Professor of English, and an affiliate member of the Mosse-Weinstein Center for Jewish Studies, at the University of Wisconsin—Madison. His most recent book is An Introduction to Holocaust Studies: History, Memory, and Representation.Oliver Marchart is a professor in the Department of Sociology, University of Lucerne, Switzerland. He is the author of books on Hannah Arendt (2005) and postfoundational political thought (2007) and (...) coeditor, with Simon Critchley, of Laclau: A Critical Reader (2004).Michèle Richman's research and publications focus primarily on the relations between Georges Bataille and other intellectuals with close ties to the French School of Sociology's founding figures, Emile Durkheim and Marcel Mauss. She is Professor of French Studies at the University of Pennsylvania.Anthony Sampson is a practicing psychoanalyst, member of the École lacanienne de psychanalyse, and teaches in the Institute of Psychology at the University del Valle, Cali, Colombia.An assistant professor of English at East Carolina University, Mikko Tuhkanen has published essays in American Literature, diacritics, African American Review, GLQ, Modern Fiction Studies, and elsewhere.Copyright © 2007 The Johns Hopkins University Press... (shrink)

Recently, von Fintel (2001) and Gillies (2007) have argued that certain sequences of counterfactuals, namely reverse Sobel sequences, should motivate us to abandon standard truth conditional theories of counterfactuals for dynamic semantic theories. I argue that we can give a pragmatic account of our judgments about counterfactuals without giving up the standard semantics. In particular, I introduce a pragmatic principle governing assertability, and I use this principle to explain a variety of subtle data concerning reverse Sobel sequences.

Recently many have argued that agents must sometimes have credences that are imprecise, represented by a set of probability measures. But opponents claim that fans of imprecise credences cannot provide a decision theory that protects agents who follow it from foregoing sure money. In particular, agents with imprecise credences appear doomed to act irrationally in diachronic cases, where they are called to make decisions at earlier and later times. I respond to this claim on behalf of imprecise credence fans. Once (...) we appreciate the complexity of our intuitions about rational decision making, we can see that diachronic cases are in fact evidence for the essential claims motivating imprecise credence models. I argue that our decision theory for imprecise agents should mirror our decision theory for agents in moral dilemmas, and I develop permissive norms that explain our intuitions about both sorts of agents. (shrink)

Something Aristotle calls ‘right logos’ plays a crucial role in his theory of virtue. But the meaning of ‘logos’ in this context is notoriously contested. I argue against the standard translation ‘reason’, and—drawing on parallels with Plato’s work, especially the Laws—in favor of its being used to denote what transforms an inferior epistemic state into a superior one: an explanatory account. Thus Aristotelian phronēsis, like his and Plato’s technē and epistēmē, is a matter of grasping explanatory accounts: in this case, (...) accounts that identify the right action and say why it is right. Arguably, Aristotelian rationality is a matter of being able to grasp accounts in general. (shrink)

Insight is Bernard Lonergan's masterwork. It aim is nothing less than insight into insight itself, a comprehensive view of knowledge and understanding, and to state what one needs to understand and how one proceeds to understand it. In Lonergan's own words: 'Thoroughly understand what it is to understand, and not only will you understand the broad lines of all there is to be understood but also you will possess a fixed base, and invariant pattern, opening upon all further developments (...) of understanding.' The editors of the Collected Works of Bernard Lonergan have established the definitive text for Insight after examining all the variant forms in Lonergan's manuscripts and papers. The volume includes introductory material and annotation to enable the reader to appreciate more fully this challenging work. (shrink)

Presents Bernard Lonergan's five "verbum" articles that originally appeared in Theological studies. For Thomist students and scholars this "verbum" study offers a careful appraisal of the Thomist theory of knowledge as well as an introduction to the concepts found in Father Lonergan's "Insight". Since the concept of "verbum" dynamically affects the thought of Aquinas, it is necessary to grasp this concept to understand Thomist metaphysics and rational psychology. Lonergan has carefully analyzed and explicitly outlined "verbum"--An integral part of the (...) Thomist theory of knowledge. "Verbum" is examined as a tool of definition and for its impact on understanding, logical thought procession and related ideas stemming from "verbum". Discusses "the word" and its relation to abstraction. Focusses on St. Thomas' immediate concern in finding in Aristotle the point of insertion for Augustinian thought and in fusing a phenomenology of the subject with a psychology of the soul. (shrink)

This paper argues that several leading theories of subjunctive conditionals are incompatible with ordinary intuitions about what credences we ought to have in subjunctive conditionals. In short, our theory of subjunctives should intuitively display semantic humility, i.e. our semantic theory should deliver the truth conditions of sentences without pronouncing on whether those conditions actually obtain. In addition to describing intuitions about subjunctive conditionals, I argue that we can derive these ordinary intuitions from justified premises, and I answer a possible worry (...) for my derivation by refuting a subjunctive triviality result modeled on (Lewis 1976). I conclude that the debate over the correct theory of subjunctive conditionals requires settling meta-philosophical questions about the relative value of various virtues of first-order theories of subjunctive conditionals. (shrink)

Contemporary philosophical discourse has deeply problematized the possibility of absolute existence. Hegel’s Foundation Free Metaphysics demonstrates that by reading Hegel’s Doctrine of the Concept in his Science of Logic as a form of Absolute Dialetheism, Hegel’s logic of the concept can account for the possibility of absolute existence. Through a close examination of Hegel’s concept of self-referential universality in his Science of Logic, Moss demonstrates how Hegel’s concept of singularity is designed to solve a host of metaphysical and epistemic (...) paradoxes central to this problematic. He illustrates how Hegel’s revolutionary account of universality, particularity, and singularity offers solutions to six problems that have plagued the history of Western philosophy: the problem of nihilism, the problem of instantiation, the problem of the missing difference, the problem of absolute empiricism, the problem of onto-theology, and the third man regress. Moss shows that Hegel’s affirmation and development of a revised ontological argument for God’s existence is designed to establish the necessity of absolute existence. By adopting a metaphysical reading of Richard Dien Winfield’s foundation free epistemology, Moss critically engages dominant readings and contemporary debates in Hegel scholarship. Hegel’s Foundation Free Metaphysics will appeal to scholars interested in Hegel, German Idealism, 19th- and 20th-century European philosophy, metaphysics, epistemology, and contemporary European thought. (shrink)

Interventions that are designed to stem plagiarism do not always override the motivation of individuals to cheat and, therefore, may not diminish misconduct. To inform more effective approaches, we conducted a systematic review to clarify the psychological causes of plagiarism. This review of 83 empirical papers showed that a specific blend of circumstances may foster plagiarism: an emphasis on competition and success rather than development and cooperation coupled with impaired resilience, limited confidence, impulsive tendencies, and biased cognitions. Fortunately, whenever students (...) feel their life and studies align to their future aspirations, many of these circumstances tend to dissipate. (shrink)

A computable structure $\mathcal {A}$ is $\mathbf {x}$-computably categorical for some Turing degree $\mathbf {x}$ if for every computable structure $\mathcal {B}\cong\mathcal {A}$ there is an isomorphism $f:\mathcal {B}\to\mathcal {A}$ with $f\leq_{T}\mathbf {x}$. A degree $\mathbf {x}$ is a degree of categoricity if there is a computable structure $\mathcal {A}$ such that $\mathcal {A}$ is $\mathbf {x}$-computably categorical, and for all $\mathbf {y}$, if $\mathcal {A}$ is $\mathbf {y}$-computably categorical, then $\mathbf {x}\leq_{T}\mathbf {y}$. We construct a $\Sigma^{0}_{2}$ set whose degree (...) is not a degree of categoricity. We also demonstrate a large class of degrees that are not degrees of categoricity by showing that every degree of a set which is 2-generic relative to some perfect tree is not a degree of categoricity. Finally, we prove that every noncomputable hyperimmune-free degree is not a degree of categoricity. (shrink)

This paper uses some modest claims about knowledge to identify a significant problem for contemporary American trial procedure. First, suppose that legal proof requires knowledge. In particular, suppose that the defendant in a jury trial is proven guilty only if the jury knows that the defendant is guilty. Second, suppose that knowledge is subject to pragmatic encroachment. In particular, whether the jury knows the defendant is guilty depends on what’s at stake in their decision to convict, including the consequences that (...) the defendant may face if convicted. Then in order to know whether a defendant has been proven guilty, jurors may need to know something about the potential consequences of conviction. But in nearly every American criminal trial, this information is withheld from jurors. -/- In §1, I lay out the philosophical premises of my argument. In §2, I say more about why these premises present a problem for American trial procedure, and I identify social and political structures that exacerbate the problem. I describe the reasoning that has led courts to withhold sentencing information from jurors, and I diagnose the flaw in this reasoning. In §3, I expand my initial argument, strengthening its conclusions and offering alternative sets of premises that still entail them. I argue that the legal ramifications of pragmatic encroachment depend on highly controversial questions in epistemology, questions about the precise nature of practical stakes. In §4, I propose strategies for legal reform. (shrink)

Philosophy and Phenomenological Research, Volume 103, Issue 3, Page 620-638, November 2021.

The Prague Philosopher Bernard Bolzano (1781-1848) has long been admired for his groundbreaking work in mathematics: his rigorous proofs of fundamental theorems in analysis, his construction of a continuous, nowhere-differentiable function, his investigations of the infinite, and his anticipations of Cantor's set theory. He made equally outstanding contributions in philosophy, most notably in logic and methodology. One of the greatest mathematician-philosophers since Leibniz, Bolzano is now widely recognised as a major figure of nineteenth-century philosophy. Praised by Husserl as “one (...) of the greatest logicians of all times,” he has also been recognised by Michael Dummett as one of the first modern analytic philosophers and by Alberto Coffa as the founder of the “semantic tradition.” This volume contains English translations of the essay “On the Mathematical Method,” a concise introduction to Bolzano’s logic and philosophy of mathematics, as well as substantial selections from his correspondence with Franz Exner, Professor of Philosophy at the Charles University in Prague in the 1830s and 40s. It will be of interest to students of Austrian philosophy, the development of analytic philosophy, the philosophy of language, and the history and philosophy of logic and mathematics. (shrink)

Plato links pleasure with illusion, and this link explains his rejection of the view that all desires are rational desires for the good. The Protagoras and Gorgias show connections between pleasure and illusion; the Republic develops these into a psychological theory. One part of the soul is not only prone to illusions, but also incapable of the kind of reasoning that can dispel them. Pleasure appears good; therefore this part of the soul (the appetitive part) desires pleasures qua good but (...) ignores reasoning about what is really good. Hence the new moral psychology of the Republic: not all desires are rational, and thus virtue depends on bringing one's non-rational desires under the control of reason. (shrink)

If there is any consensus about knowledge in contemporary epistemology, it is that there is one primary kind: knowledge-that. I put forth a view, one I find in the works of Aristotle, on which knowledge-of – construed in a fairly demanding sense, as being well-acquainted with things – is the primary, fundamental kind of knowledge. As to knowledge-that, it is not distinct from knowledge-of, let alone more fundamental, but instead a species of it. To know that such-and-such, just like to (...) know a person or place, is to be well-acquainted with a portion of reality – in this case a fact. In part by comparing classic Gettier cases to cases in which one has true impressions of but fails to know a person, I argue that this account not only respects our intuitions about knowledge-that – in particular that it is or entails non-accidentally true justified belief – but also explains them, providing a compelling analysis. (shrink)

The existence claim of a "genetic program" encoded in the DNA molecule which controls biological processes such as development has been examined. Sources of belief in such an entity are found in the rhetoric of Mendelian genetics, in the informationist speculations of Schrodinger and Delbruck, and in the instrumental efficacy found in the use of certain viral, and molecular genetic techniques. In examining specific research models, it is found that attempts at tracking the source of biological control always leads back (...) to the complex state of a cell as a whole, the organizational structure of which is not itself encoded in the DNA. It is argued that the "genetic program" is not an existing biological entity and its philosophical and heuristic status is challenged. (shrink)

This is a ground-breaking study of the way educated people were trained to think in Renaissance Europe. As Ann Moss demonstrates, the commonplace-book of quotations which every schoolboy of the period was taught to use opens a window on to the manner in which attitudes were structured, a moral consensus was established, and styles of writing evolved. Printed Commonplace-Books and the Structuring of Renaissance Thought is much more than an account of humanist classroom practice: it is a major work (...) of cultural history. (shrink)

New methods to analyse social media data provide a powerful way to know publics and capture what they say and do. At the same time, access to these methods is uneven, with corporations and governments tending to have best access to relevant data and analytics tools. Critics raise a number of concerns about the implications dominant uses of data mining and analytics may have for the public: they result in less privacy, more surveillance and social discrimination, and they provide new (...) ways of controlling how publics come to be represented and so understood. In this paper, we consider if a different relationship between the public and data mining might be established, one in which publics might be said to have greater agency and reflexivity vis-à-vis data power. Drawing on growing calls for alternative data regimes and practices, we argue that to enable this different relationship, data mining and analytics need to be democratised in three ways: they should be subject to greater public supervision and regulation, available and accessible to all, and used to create not simply known but reflexive, active and knowing publics. We therefore imagine conditions in which data mining is not just used as a way to know publics, but can become a means for publics to know themselves. (shrink)

I demonstrate that the theory of persistence defended in Sider [2001] does not accommodate our intuitions about counting sentences. I develop two theories that improve on Sider's: a contextualist theory and an error theory. I argue that the latter is stronger, simpler, and better fitted to some important ordinary language judgments than rival four-dimensionalist theories of persistence.

de Anima III.10 characterizes akrasia as a conflict between phantasia (“imagination”) on one side and rational cognition on the other: the akratic agent is torn between an appetite for what appears good to her phantasia and a rational desire for what her intellect believes good. This entails that akrasia is parallel to certain cases of perceptual illusion. Drawing on Aristotle's discussion of such cases in the de Anima and de Insomniis , I use this parallel to illuminate the difficult discussion (...) of akrasia in Nicomachean Ethics VII.3, arguing that its account of akrasia as involving ignorance is compatible with, and in fact crucially supplements, the more straightforward account we find elsewhere in the corpus of akrasia as a struggle between desires. (shrink)

From his earliest work forward, phenomenologist Maurice Merleau-Ponty attempted to develop a new ontology of nature that would avoid the antinomies of realism and idealism by showing that nature has its own intrinsic sense which is prior to reflection. The key to this new ontology was the concept of form, which he appropriated from Gestalt psychology. However, Merleau-Ponty struggled to give a positive characterization of the phenomenon of form which would clarify its ontological status. Evan Thompson has recently taken up (...) Merleau-Ponty’s ontology as the basis for a new, “enactive” approach to cognitive science, synthesizing it with concepts from dynamic systems theory and Francisco Varela’s theory of autopoiesis. However, Thompson does not quite succeed in resolving the ambiguities in Merleau-Ponty’s account of form. This article builds on an indication from Thompson in order to propose a new account of form as asymmetry, and of the genesis of form in nature as symmetry-breaking. These concepts help us to escape the antinomies of Modern thought by showing how nature is the autoproduction of a sense which can only be known by an embodied perceiver. (shrink)