In the life sciences, there is an ongoing discussion about a perceived ‘reproducibility crisis’. However, it remains unclear to which extent the perceived lack of reproducibility is the consequence of issues that can be tackled and to which extent it may be the consequence of unrealistic expectations of the technical level of reproducibility. Large-scale, multi-institutional experimental replication studies are very cost- and time-intensive. This Perspective suggests an alternative, complementary approach: meta-research using sociological and philosophical methodologies to examine researcher trust in (...) data. An improved understanding of the criteria used by researchers to judge data reliability will provide crucial, initial evidence on the actual scale of the reproducibility crisis and on measures to tackle it. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Notre temps est, dit-on, celui des catastrophes. Sur les nouveaux fronts de l’écologie, du changement climatique ou de la menace nucléaire, les idéologies du progrès ont cédé la place à l’angoisse. Mais la résurgence des thèmes apocalyptiques est bien plus que le symptôme d’une période de crise : dès les XVIe et XVIIe siècles, avec la disparition du cosmos comme ordre hiérarchisé au sein duquel l’homme occupait une position privilégiée, est née une nouvelle inquiétude : celle de devoir vivre « (...) après la fin du monde ». Ce livre voudrait montrer que le plus urgent n’est pas d’éviter la catastrophe à venir, mais de repenser et de réinvestir le monde de manière nouvelle. Michaël Foessel interprète les peurs apocalyptiques actuelles à partir des expériences contemporaines où les sujets se sentent dépossédés du monde : triomphe de la technique sur l’action, du capital sur le travail, du besoin sur le désir. Pour cela, il propose une généalogie de l’idée de « fin du monde » qui distingue deux voies de la modernité : celle qui privilégie la vie et sa conservation, aujourd’hui à l’oeuvre dans la plupart des conceptions écologiques et précautionneuses du réel ; celle qui fait du monde le thème principal de la philosophie en même temps qu’un enjeu politique de premier ordre. Nous sommes désormais face à une alternative : perpétuer la vie ou édifier un monde. Les théories de la catastrophe ne se soucient plus de savoir quel monde mérite d’être défendu. En ce sens, le fait que la fin du monde a déjà eu lieu est une bonne nouvelle : cela nous invite à inventer des espaces pour l’action et à fonder un nouveau cosmopolitisme. (shrink)

" L'énigme, c'est précisément qu'il semble évident que le monde existe pour nous. " C'est à cette énigme que se confronte Kant dès ses premiers écrits. Le projet critique de Kant prend son origine dans la critique de la cosmologie classique. A chaque étape de son développement, des écrits pré-critiques à l'Opus postumum, le rapport au monde est spécifié, que ce soit du point de vue de la sensibilité, de la connaissance ou de la morale. Avec Kant s'ouvre un nouvel (...) horizon pour l'homme, comme " habitant du monde ". Le monde moral et surtout le concept de liberté dont l'origine est cosmologique prennent une nouvelle dimension et se substituent à un hypothétique " monde intelligible ". C'est l'occasion pour Michaël Foessel de revisiter la " maison Kant " dans ses coins et recoins, de mettre à l'épreuve la rationalité de l'édifice, dans une confrontation féconde entre Kant, Husserl et Heidegger. Une lecture forte et vivifiante. (shrink)

En 1789, la Révolution française met la liberté à l'ordre du jour. C'est un événement pour la philosophie qui, au siècle des Lumières, a activement participé à la critique du despotisme. C'est aussi un événement philosophique qui délivre à la pensée de nouveaux horizons où les maîtres-mots sont souveraineté politique du peuple et autonomie morale du sujet. De Rousseau, qui fait de la liberté le fondement de toute légitimité, à Hegel pour qui "l'esprit est liberté", en passant par Kant qui (...) consacre le droit inaliénable des peuples à disposer d'eux-mêmes, Michaël Foessel revient sur cette période philosophique si intense. Au cours de ces bouleversements historiques s'élabore une définition de la liberté irréductible au libéralisme. C'est parce que notre époque est incertaine sur le sens de la liberté qu'il vaut la peine d'entendre à nouveau l'exigence d'autonomie portée par la philosophie, de Rousseau à Hegel. (shrink)

v. 1. Opuscula logica, physica, allegorica, alia -- v. 2. Opuscula psychologica, theologica, daemonologica.

This book offers a new account of the origins of modern biblical criticism. Focusing on the scholarship of J. D. Michaelis , it shows how critics created a post-theological academic Bible to replace Europe's scriptural Bibles and assimilate biblical scholarship to the social goals of the Enlightenment.

Commentaries on Aristotle's writings have been produced since the 2nd century AD. This edition contains Greek commentaries on his work from the 3rd to the 8th centuries AD by, among others, Alexander of Aphrodiensias, Themistios, Joh. Philoponus, Simplicius in Greek.

Seit dem 2. nachchristlichen Jahrhundert werden die Schriften von Aristoteles kommentiert. Diese Ausgabe enthält griechische Kommentare zu seinem Werk vom 3. bis 8. Jahrhundert n. Chr., u. a. von Alexander von Aphrodiensias, Themistios, Joh. Philoponus, Simplicius in griechischer Sprache.

Michael Walzer zahlt zu den bedeutendsten politischen Theoretikern der Gegenwart. Gleichwohl weist die weltweite Aufmerksamkeit einen `blinden` Fleck auf, wenn es darum geht, Walzers kommunitaristische Gerechtigkeitsphilosophie vor dem Hintergrund der judischen politischen Theorie zu situieren. Diese Lucke will der Sammelband schliessen, indem erstmals im deutschsprachigen Raum die vielschichtigen Interdependenzen zwischen Religion und Politik in Walzers Werk unter dem Stichwort der Politischen Theologie systematisch interpretiert werden. Mit Beitragen von:Edmund Arens, Thomas Bedorf, Micha Brumlik, Martin Hartmann, Michael Haus, Otto Kallscheuer, Joachim J. (...) Krause, Skadi Krause, Michael Kuhnlein, Jurgen Manemann, John Milbank, Peter Nitschke, Henning Ottmann, Rolf Schieder, Christoph Seibert, Michael Walzer, Jean-Pierre Wils und einer Replik von Michael Walzer. (shrink)

Die hiermit herausgegebene Briefsammlung des Bischofs von Athen Michael Choniates ist unter zweierlei Aspekten besonders wichtig: Einerseits wegen der Information, die uns über die Zustände im byzantinischen Reich im allgemeinen und in Athen und Umgebung bzw. auf einigen Inseln der Ägäis insbesondere sowie über die Gesellschaft jener Zeit (Ende des 12. – Anfang des 13. Jahrhunderts) bietet, andererseits wegen der Briefe selbst, die nicht nur die starke Orientierung der zeitgenössischen Gelehrten auf die Literatur des alten Hellas verraten, sondern auch unter (...) den anmutigsten und stilistisch interessantesten, die je in byzantinischer Zeit abgefaßt wurden, zählen. (shrink)

At Protagoras 353de, Socrates gives three possible reasons for calling some pleasures ‘wrong’. Scholarly attention has focused on the second of these, according to which pleasures are ‘wrong’ when they have negative consequences. This paper argues that the first reason corresponds to beliefs held by Democritus, among others; and that the third reason is the view adopted by Socrates in the dialogue.

Speakers’ perception of a visual scene influences the language they use to describe it—which objects they choose to mention and how they characterize the relationships between them. We show that visual complexity can either delay or facilitate description generation, depending on how much disambiguating information is required and how useful the scene's complexity can be in providing, for example, helpful landmarks. To do so, we measure speech onset times, eye gaze, and utterance content in a reference production experiment in which (...) the target object is either unique or non-unique in a visual scene of varying size and complexity. Speakers delay speech onset if the target object is non-unique and requires disambiguation, and we argue that this reflects the cost of deciding on a high-level strategy for describing it. The eye-tracking data demonstrate that these delays increase when speakers are able to conduct an extensive early visual search, implying that when speakers scan too little of the scene early on, they may decide to begin speaking before becoming aware that their description is underspecified. Speakers’ content choices reflect the visual makeup of the scene—the number of distractors present and the availability of useful landmarks. Our results highlight the complex role of visual perception in reference production, showing that speakers can make good use of complexity in ways that reflect their visual processing of the scene. (shrink)

The article examines philosophical conceptions of responsibility found in the contributions of Martin Buber, Hans Jonas and Emmanuel Levinas. It argues that, despite the significant differences of these contributions, they all share important goals, significant structural features, and corresponding challenges. All three thinkers try to overcome the solipsistic limitations of Edmund Husserl’s phenomenology as well as the egocentrism of Heidegger’s concept of "solicitude" or "self-care." All three try to overcome the Kantian subject-object dichotomy. All three understand responsibility as a bipolar (...) relation only. In consequence, all of them face similar challenges resulting from new forms of dichotomies and the exclusion of “thirdness” that are the result of their conceptual decisions. (shrink)

The book introduces a conception of discourse ethics, an intersubjectivist version of Kantian ethics. Analyzing contributions from Jürgen Habermas, Karl-Otto Apel, Wolfgang Kuhlmann, Albrecht Wellmer, Robert Alexy, Klaus Günther, Rainer Forst, Marcel Niquet and others, it reconstructs critical discussions on the justification of the principle of morality (part I) and on the various proposals on how to apply it (part II). It defends an alternative model of how discourse ethics can provide guidance under non-ideal circumstances and avoid both arbitrariness and (...) rigorism. (shrink)

In der Technikethik spielt das Konzept der Verantwortung eine zentrale Rolle. ›Verantwortung‹ ist ein Basiskonzept, das, ähnlich wie die Konzepte ›Pflicht‹ oder ›Schuld‹, in vielfältigen Kontexten gebraucht wird. Dennoch lassen sich einige allgemeine Aussagen über seine Bedeutung treffen. Gerade Autoren, die im Bereich der Technik- und Wissenschaftsethik aktiv sind, haben sich nachdrücklich um eine Klärung des allgemeinen Verantwortungsbegriffs und seiner verschiedenen Aspekte und Gebrauchsweisen bemüht.

The playful discussion of 'horsemanship' that opens Sir Philip Sidney's Defence of Poesie has been variously interpreted as a straightforward anecdote about the chivalric arts, or an oblique rhetorical flourish, or something in between. This essay suggests a new context for Sidney's exordium by focusing primarily on its affiliation to the genre of the 'Art of Poetry'. In Horace's Ars poetica and other classical, scholastic and Renaissance treatises, horse–men and other unnatural hybrids embody the tension between decorum and poetic liberty. (...) Three major traditions inform this trope: by the Renaissance the centaur could be an allegory of reason's struggle with the passions, an emblem of the poetic imagination, or a figure for compositional hybridity associated, especially, with Lucianic satire. Reading Sidney in the light of these traditions, finally, this essay explores aspects of the centaur's significance in the Defence and the Arcadia, and suggests that this kind of attention to metaphor might provide a bridge between critical and creative modes of Renaissance poetic thought. (shrink)

According to the received account of guilt in the philosophical literature, one cannot feel guilt unless one takes oneself to have done something morally wrong. But ordinary people feel guilt in many cases in which they do not take themselves to have done anything morally wrong. In this paper, I focus on one kind of guilt without perceived wrongdoing, guilt about being merely causally responsible for a bad state-of-affairs. I go on to present a novel account of guilt that explains (...) guilt about mere causal responsibility, according to which guilt represents part of the self as bound up with what is bad. (shrink)

Hatte Jeremy Bentham den von ihm geprägten Begriff deontology in seinem gleichnamigen Werk noch im etymologisch buchstäblichen Sinne als »Lehre vom Sollen« verstanden und mit der »Wissenschaft von der Moral« gleichgesetzt, so dient das Adjektiv ›deontologisch‹ heutzutage ausschließlich der Kategorisierung einer spezifischen Teilklasse allgemeiner Konzeptionen normativer Ethik. ›Deontologische‹ Theorien normativer Ethik werden dann in der Regel ›teleologischen‹ Theorien, und/oder ›konsequentialistischen‹ Theorien gegenübergestellt.

The article reviews the various ramifications in the discussion on leadership, focusing on the view of leadership as relationships between leaders and followers. Three main types of leader-follower relations are discussed, and their specific characteristics are described: regressive relations, symbolic relations, and developmental relations. After analyzing the major implications, as well as the conceptual limitations, of these perspectives, the article suggests directions for a more integrative conceptualization of leader-follower relations.

Cet ouvrage est une réédition numérique d’un livre paru au XXe siècle, désormais indisponible dans son format d’origine.

Two questions are addressed in this article: 1. Why are people attracted to leaders? 2. How are leaders' images construed? The first question is analyzed by using the concept of “deity” as a frame of reference for an “ideal model” of leadership. God as a “screen of projections” can satisfy the believer's fundamental needs and desires, as well as serving as a reference for causal attributions and a provider of transcendental meaning. Using Construal Level Theory, deity, as a frame of (...) reference, also facilitates analysis of the second question. This analysis explains universal principles underlying the leadership construal, and the psychological principles and culture-bound processes relevant to construing different images of leadership in different collectives. (shrink)

Two questions are addressed in this article: 1. Why are people attracted to leaders? 2. How are leaders' images construed? The first question is analyzed by using the concept of “deity” as a frame of reference for an “ideal model” of leadership. God as a “screen of projections” can satisfy the believer's fundamental needs and desires, as well as serving as a reference for causal attributions and a provider of transcendental meaning. Using Construal Level Theory, deity, as a frame of (...) reference, also facilitates analysis of the second question. This analysis explains universal principles underlying the leadership construal, and the psychological principles and culture-bound processes relevant to construing different images of leadership in different collectives. (shrink)

The fact that Gilbert Ryle and J.L. Austin seem to disagree about the ordinary use of words such as ‘voluntary’, ‘involuntary’, ‘voluntarily’, and ‘involuntarily’ has been taken to cast doubt on the methods of ordinary language philosophy. As Benson Mates puts the worry, ‘if agreement about usage cannot be reached within so restricted a sample as the class of Oxford Professors of Philosophy, what are the prospects when the sample is enlarged?’ (Mates, Inquiry 1:161–171, 1958, p. 165). In this chapter, (...) we evaluate Mates’s criticism alongside Ryle’s and Austin’s specific claims about the ordinary use of these words, assessing these claims against actual examples of ordinary use drawn from the British National Corpus (BNC). Our evaluation consists in applying a combination of methods: first aggregating judgments about a large set of samples drawn from the corpus, and then using a clustering algorithm to uncover connections between different types of use. In applying these methods, we show where and to what extent Ryle’s and Austin’s accounts of the use of the target terms are accurate as well as where they miss important aspects of ordinary use, and we demonstrate the usefulness of this new combination of methods. At the heart of our approach is a commitment to the idea that systematically looking at actual uses of expressions is an essential component of any approach to ordinary language philosophy. (shrink)

1. In the opening chapter of his arresting book on Immanuel Kant’s philosophy of international and cosmopolitan right, Kant and the Law of War,1 Arthur Ripstein presents Kant’s position as a respon...

A l'été 2019, le parlement français se saisira de la loi sur la bioéthique. Ajouter une pierre au débat, tel est l'objectif de ce court livre qui aborde les différentes questions liées à l'éthique et aux sujets actuellement en débat au sein de la société française et sur lesquels le parlement sera amené à délibérer : - procréation (PMA, GPA), - fin de vie (assistance au suicide, accompagnement des malades en fin de vie), - dons d'organes, - intelligence artificielle.

Open access-introduction into moral philosophy in German language that contains chapters on the concept of morality, on the development and the main positions of normative ethics, on meta-ethics, and on the various fields of applied ethics. One of its distinctive features is that it explicitly reflects on the role of morality and ethics in modern society and that it analyses the import of alternative conceptual and normative positions for determining this role. The book can be freely downloaded from the publisher's (...) website via the URL below. (shrink)

Our aim in this paper is to present the distinct ways in which Wolff, Baumgarten, and Kant understand the relationship between necessitation, constraint, and reluctant action in an effort to illustrate the subtle ways in which their conceptions of obligation differ from each another. Whereas Wolff conceives of natural or moral obligation as incompatible with constraint, Baumgarten holds that constraint and reluctant action are, in some instances, compatible with natural obligation. Kant departs from Baumgarten by conceiving of obligation as necessarily (...) involving constraint: as Kant’s reply to Schiller’s famous objection reveals, obligation must take on the character of constraint to reluctant action on account of the fact that human beings possess inclinations that always threaten to impel them in directions that oppose morality. (shrink)

What is the relation between small-scale collaborative plans and the execution of those plans within interactive contexts? I argue here that joint attention has a key role in explaining how shared plans and shared intentions are executed in interactive contexts. Within singular action, attention plays the functional role of enabling intentional action to be guided by a prior intention. Within interactive joint action, it is joint attention, I argue, that plays a similar functional role of enabling the agents to act (...) in a collaborative way such that their actions are rationally guided by a prior shared intention. This understanding of joint attention – as having a key functional role of enabling the rational guidance of joint intentional action by a prior shared intention – allows for an alternative understanding of the kind of minimal cooperation that infants can engage in. On this understanding, infants’ capacity to engage in joint actions is already an incipient capacity to engage in rational and intentional joint actions, albeit a capacity that is necessarily scaffolded by an adult rational co-partner. (shrink)