The Drosophila tracheal system is a branched tubular structure that supplies air to target tissues. The elaborate tracheal morphology is shaped by two linked inductive processes, one involving the choice of cell fates, and the other a guided cell migration. We will describe the molecular basis for these processes, and the allocation of cell fate decisions to four temporal hierarchies. First, tracheal placodes are specified within the embryonic ectoderm. Subsequently, branch fates are allocated within the tracheal placodes, prior to migration. (...) Localized presentation of the FGF ligand, Branchless, to tracheal cells that express the FGF receptor, Breathless, guides migration. Once cell migration is initiated, distinct cell fates are determined within each migrating branch. Finally, inhibitory feedback mechanisms ensure the correct assignment of these fates. Tracheal cell fate choices are determined by signaling cascades triggered by signals emanating from the tracheal cells, as well as by ligands produced by adjacent tissues. BioEssays 22:219–226, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Cognitive Science, Volume 46, Issue 2, February 2022.

Explores how republican political thought can make a constructive and distinctive contribution to our understanding of democracy and the challenges it faces.

An examination of the statement, criticism, and reformulation of the Pirenne, Turner, and Weber theses as causal explanations makes possible a clarification of the nature and justification of causal theses in history. Criticisms of such theses typically attack either the description of the cause-phenomenon or the effect-phenomenon, or they attack the generalization or theory which justifies the claim of causal connection. Theses are defended by redescribing the phenomena so as to make the underlying theory a stronger justification. The analysis clarifies (...) the essential connection between description and explanation, and shows that "colligatory" descriptions are always theoretical relative to lower-level factual descriptions. (shrink)

With his characteristic wit, Zizek addresses the burning question of how to reformulate a leftist project in an era of global capitalism and liberal-democratic ...

In Less Than Nothing, the pinnacle publication of a distinguished career, Slavoj i ek argues that it is imperative that we not simply return to Hegel but that we repeat and exceed his triumphs, overcoming his limitations by being even more ...

Summary According to the contemporary hermeneutical school the distinguishing feature of the humanities is the capability of the inquirer to communicate with the object of his inquiry. This idea underlies K.-O. Apel's model for the humanities adopted from psycho-analytical therapy. It is argued (1) that there is no sense in which the object of the historical inquiry can be regarded as aKommunikationspartner of the historian; and (2) that when the traditionalVerstehen doctrine is re-interpreted counterfactually (e.g., If I were Caesar, then (...) ... substantiates my explanations of Caesar's actions), then the doctrine has an acceptable application to history and the charge of psychologism is removed. (shrink)

This chapter contains sections titled: The Counterfactual Character of Historiography Understanding Metaphysical Preliminaries Causal Counterfactual Analysis in Historiography Counterfactuals and Practical Reasoning Science and Counterfactuals References Further Reading.

“All history is the re-enactment of past thought in the historian’s own mind,” wrote Collingwood in one of his succinct expressions of what seemed to him a universal truth about history. Since the appearance of his posthumous book The Idea of History in 1946, allusions to the reenactment doctrine have been most popular among writers on methodology of history. In particular, re-enactment has evoked the warm response of working historians. In many cases, however, mention of re-enactment has not revealed any (...) serious interest in the question of its meaning and nature. Some clarifications have been made, but in my opinion, most of them have not been in the right direction. (shrink)

“All history is the re-enactment of past thought in the historian’s own mind,” wrote Collingwood in one of his succinct expressions of what seemed to him a universal truth about history. Since the appearance of his posthumous book The Idea of History in 1946, allusions to the reenactment doctrine have been most popular among writers on methodology of history. In particular, re-enactment has evoked the warm response of working historians. In many cases, however, mention of re-enactment has not revealed any (...) serious interest in the question of its meaning and nature. Some clarifications have been made, but in my opinion, most of them have not been in the right direction. (shrink)

This article reconstructs Adam Smith’s contribution to the conversation on the nature and value of free government in the eighteenth century. Smith contributes to this conversation in two ways. First, by embedding the idea of free government in a narrative of the progress of government, which traces the interplay between natural progress and social circumstances, and culminates in the establishment of modern free government in Britain. Second, by offering a theory of the form of free government fit for modern commercial (...) states. Drawing on the “rational system of liberty” established in Britain, the Smithian model of free government is based on a “happy mixture” of republicanism and monarchism. Looking beyond the rational system, it merges the traditional concern for constitutional security against arbitrary power with a new science of policy intended to moderate the oppressive inclinations of legislators. The article contests Duncan Forbes’ reading of Smith as questioning the relation between individual liberty and free government, and brings Smith closer to Quentin Skinner’s work on the neo-Roman understanding of liberty. It suggests that Smith’s work may offer insight into some of the ways in which neo-Roman ideas were being creatively reformulated in the eighteenth century. (shrink)

The latest book by the Slovenian critic Slavoj Zizek takes the work of French philosopher Gilles Deleuze as the beginning of a dazzling inquiry into the realms of radical politics, philosophy, film (Hitchcock, Fight Club ), and psychoanalysis. Of Organs without Bodies Joan Copjec ( Imagine There's No Woman ) has written: "With all his ususal humor and invention, Zizek -- the acknowledged master of the 180 degree turn -- here takes a trip into "enemy" territory to deliver Deleuze of (...) a marvelously rebellious child, one that seriously challenges Deleuze's other progeny with a surprising but convincing bid for succession. Those who thought Deleuze's forward march into the future would follow a straight path are forced to rethink their stance. From now on all readings of Deleuze will have to take a detour through this important -- even necessary -- book." Eric Santner ( On the Psychopathology of Everyday Life ) describes Organs without Bodies as offering "an entirely new degree of conceptual clarity and political urgency. Through his deep engagement with the logic of Deleuze's project, Zizek opens up new possibilities of thought beyond the terms of the current political debates on globalization, democratization, war on terror. Once again, Zizek has produced an utterly timely and radically untimely meditation." Recently profiled in The New Yorker , and hailed by the Village Voice as "the giant of Ljubljana," Zizek is one of the most provocative and entertaining thinkers at work today. (shrink)

Book synopsis: In this combative major new work, philosophical sharpshooter Slavoj Zizek looks for the kernel of truth in the totalitarian politics of the past. Examining Heidegger's seduction by fascism and Foucault's flirtation with the Iranian Revolution, he suggests that these were the 'right steps in the wrong direction.' On the revolutionary terror of Robespierre, Mao and the bolsheviks, Zizek argues that while these struggles ended in historic failure and horror, there was a valuable core of idealism lost beneath the (...) bloodshed. A redemptive vision has been obscured by the soft, decentralized politics of the liberal-democratic consensus. Faced with the coming ecological crisis, Zizekk argues the case for revolutionary terror and the dictatorship of the proletariat. A return to past ideals is needed despite the risks. In the words of Samuel Beckett: 'Try again. Fail again. Fail better.'. (shrink)

This paper aims first and foremost to unravel and clarify an interesting 17th century controversy around superposition in projectiles, which allegedly existed between the French Jesuit Honoré Fabri and the Italian physicist and astronomer Giovanni Alfonso Borelli. This conflict – initially described by the English mathematician John Wallis in a letter from 1670 to the secretary of the Royal Society – has been erroneously identified with Fabri's Dialogi physici (1669), a work written in response to Borelli's De vi percussionis (1669). (...) In fact, this “conflict” was nothing but Wallis's account of a contradiction between Borelli's above mentioned work and Fabri's Tractatus physicus de motu locali from 1646, while Fabri's 1669 work expressed views very different from those contained in his Tractatus physicus. I will try here to reconstruct Fabri's change of heart between 1646 and 1669 concerning projectiles and superposition, while tracing the real bone of contention between (the later) Fabri and Borelli – superimposing contrary motions – to its Aristotelian origins. My analysis will lead me to problematize the way modern historians usually interpret the relation between Aristotle's physical thinking and projectile theories of early modern theoreticians (e.g. Nicollò Tartaglia's). (shrink)

Whenever the membranes of the egg in which the foetus emerges on its way to becoming a new-born are broken, imagine for a moment that something flies off, and that one can do it with an egg as easily as with a man, namely the hommelette, or the lamella. The lamella is something extra-flat, which moves like the amoeba. It is just a little more complicated. But it goes everywhere. And as it is something - I will tell you shortly (...) why - that is related to what the sexed being loses in sexuality, it is, like the amoeba in relation to sexed beings, immortal - because it survives any division, and scissiparous intervention. And it can turn around. Well! This is not very reassuring. But suppose it comes and envelopes your face while you are quietly asleep... I can't see how we would not join battle with a being capable of these properties. But it would not be a very convenient battle. This lamella, this organ, whose characteristic is not to exist, but which is nevertheless an organ - I can give you more details as to its zoological place - is the libido. It is the libido, qua pure life instinct, that is to say, immortal life, irrepressible life, life that has need of no organ, simplified, indestructible life. It is precisely what is subtracted from the living being by virtue of the fact that it is subject to the cycle of sexed reproduction. And it is of this that all the forms of the objet a that can be enumerated are the representatives, the equivalents. Every word has a weight here, in this deceivingly poetic description of the mythic creature called by Lacan "lamella". Lacan imagines lamella as a version of what Freud called "partial object": a weird organ which is magically autonomized, surviving without a body whose organ it should have been, like a hand that wonders around alone in early Surrealist films, or like the smile in Alice in Wonderland that persists alone, even when the Cheshire cat's body is no longer present: "'All right', said the Cat; and this time it vanished quite slowly, beginning with the end of the tail, and ending with the grin, which remained some time after the rest of it had gone. 'Well! I've often seen a cat without a grin', thought Alice; 'but a grin without a cat! It's the most curious thing I ever saw in my life!'" The lamella is an entity of pure surface, without the density of a substance, an infinitely plastic object that can not only incessantly change its form, but can even transpose itself from one to another medium: imagine a "something" that is first heard as a shrilling sound, and then pops up as a monstrously distorted body. A lamella is indivisible, indestructible, and immortal - more precisely, undead in the sense this term has in horror fiction: not the sublime spiritual immortality, but the obscene immortality of the "living dead" which, after every annihilation, re-composes themselves and clumsily goes on. As Lacan puts it in his terms, lamella does not exist, it insists: it is unreal, an entity of pure semblance, a multiplicity of appearances which seem to envelop a central void - its status is purely fantasmatic. This blind indestructible insistence of the libido is what Freud called "death drive," and one should bear in mind that "death drive" is, paradoxically, the Freudian name for its very opposite, for the way immortality appears within psychoanalysis: for an uncanny excess of life, for an "undead" urge which persist beyond the cycle of life and death, of generation and corruption. This is why Freud equates death drive with the so-called "compulsion-to-repeat," an uncanny urge to repeat painful past experiences which seems to outgrow the natural limitations of the organism affected by it and to insist even beyond the organism's death - again, like the living dead in a horror film who just go on. This excess inscribes itself into the human body in the guise of a wound which makes the subject "undead," depriving him of the capacity to die : when this wound is healed, the hero can die in peace. (shrink)

With a new introduction by the author In this deliciously polemical work, a giant of cultural theory immerses himself in the ideas of a giant of French thought.

This article reconsiders Bentham’s theory of liberty in relation to republican and democratic ideas in the Age of Revolution. It reinterprets his jurisprudential definitions of liberty as ideological weapons intended to “cut the throat” of pro-American and proto-democratic discourse. In particular, his negative definition of individual liberty and his democratic and international definitions of political liberty were designed and used to caricature and draw to absurdity the republican ideal of self-government. The early Bentham, according to this interpretation, was a subversive (...) critic of republicanism, who occupied its language of liberty and security while trying to neutralize its democratic potential. (shrink)

In Explanation and Understanding von Wright argues that if, as he suggests, a practical inference schema is adopted as an explanation model for actions, then it follows that historical explanations are non?causal. My criticisms are principally directed against his version of the Logical Connection Argument which attempts to show that the verification of the action description to be explained and the verification of the intention description which explains it are interdependent. Von Wright blurs the important distinctions (1) between acting with (...) an intention and acting intentionally; (2) between intention to perform an action and intention to bring about a consequence of it; and (3) between verification of intention descriptions in general and of a description of a specific intention. The ?conclusion? of his practical inference schema cannot be the appropriate historical explanandum and the explaining procedure that he suggests is shown to be ultimately circular. (shrink)

After more than a decade Alexandre Métraux is leaving his post as a co-editor of Science in Context and will remain as a member of the editorial board.

ArgumentThis paper discusses the theory of motion of the philosopher Honoré Fabri (1608–1688), a senior representative of early modern Jesuit scientists. It argues that the consensus prevailing among historians – according to which Fabri's theory of impetus is diametrically opposed to Galileo's or Descartes' concept of inertia – is false. It shows: that Fabri carefully constructed his concept of impetus in order to easily incorporate the principle of linear conservation of motion (designated here as “limited inertia”), by adopting formal (rather (...) than efficient) causality between impetus and motion and by allowing impetus to act only along straight lines; that he explicitly deemed Aristotle's famous “inertial paradox” not as a paradox at all; and that linear conservation of motion was not limited to “counterfactual” circumstances but played a significant part in his discrete theory of free fall and constituted an integral component of his general physical (and even mathematical) philosophy. However, the paper also shows that Fabri's notion of inertia was restricted to one dimension only, and therefore should indeed be considered “limited.” In his analysis of horizontal projectiles, Fabri explicitly rejected Galileo's important principle of superposition, and thus revealed significant constraints to his “inertial” thinking. (shrink)

As a slew of recent work in epistemology has brought out, there is a range of cases where there's a strong temptation to say that prudential and (especially) moral considerations affect what we ought to believe. There are two distinct models of how this can happen. On the first, “reasons pragmatist” model, the relevant prudential and moral considerations constitute distinctively practical reasons for (or against) belief. On the second, “pragmatic encroachment” model, the relevant prudential and moral considerations affect what one (...) is epistemically justified in believing. The pragmatic encroachment model appears to have several advantages over reasons pragmatism, and this has led many recent philosophers to endorse the former. However, in this paper we argue that a version of reasons pragmatism can be (at least largely) saved from these purported disadvantages once paired with an independently plausible permissivism about epistemically justified outright belief. This hybrid view—“permissivist pragmatism”—holds that when there is more than one epistemically permitted doxastic attitude, practical (including moral) considerations can determine which epistemically permitted doxastic attitude one all-things-considered ought to have. This view avoids both the problems faced by simple versions of reasons pragmatism, and those that distinctively attend pragmatic encroachment, while preserving the advantages of each view. (shrink)

On Islamic teachings, written by an army officer and educationist from Pakistan.

On the dominant contemporary accounts of how practical considerations affect what we ought to believe, practical considerations either encroach on epistemic rationality by affecting whether a belief is epistemically justified, or constitute distinctively practical reasons for belief which can only affect what we ought to believe by conflicting with epistemic rationality. This paper shows that a promising alternative view can be found in a surprising source: the writings of Søren Kierkegaard. I argue that in light of two of his central (...) epistemological commitments—belief-credence dualism and epistemic permissivism about outright belief—Kierkegaard holds that practical considerations can affect what we ought to believe without either encroaching on or (necessarily) conflicting with epistemic rationality. The central idea is that practical considerations can determine which among the epistemically permitted outright doxastic attitudes one should all-things-considered adopt. In addition to constituting a novel, systematic interpretation of Kierkegaard’s account of how practical considerations affect what we ought to believe, this suggests that Kierkegaard holds a distinctive and underexplored view that constitutes a serious philosophical rival to dominant contemporary views. (shrink)

We study structures equipped with generic predicates and/or automorphisms, and show that in many cases we obtain simple theories. We also show that a bounded PAC field is simple. 1998 Published by Elsevier Science B.V. All rights reserved.