Recently, Quyn et al. demonstrated that cells within the stem cell zone of human and mouse intestinal crypts tend to align their mitotic spindles perpendicular to the basal membrane of the crypt. This is associated with asymmetric division, whereby particular proteins and individual chromatids are preferentially segregated to one daughter cell. In colonic mucosa containing a heterozygous adenomatous polyposis coli gene (APC) mutation the asymmetry is lost. Here, we discuss asymmetric stem cell division as an anti‐tumourigenic mechanism. We describe how (...) hierarchical tissue structures suppress somatic evolution, and discuss the relative merits of template strand retention to limit the accumulation of DNA replication errors. We suggest experiments to determine whether somatic mutations resulting in loss of spindle alignment confer an advantage within the stem cell niche. Finally, we discuss whether lack of spindle alignment constitutes an oncogenic event per se, with particular reference to studies in model organisms, and the timing of chromosomal instability in human cancers. (shrink)

The Canadian province of Ontario introduced philosophy as a secondary school subject in 1995 (Pinto, McDonough, & Boyd, 2009). Since publicly-funded Catholic schools teach approximately 32% of all students in Ontario (Ontario Ministry of Education, 2022), the question arises regarding how teachers in those schools coordinate philosophy and Catholic teachings. This study employs a secondary analysis of interviews with six teachers from Ontario’s Catholic schools, and employs two of Avery Dulles’ (2002) conceptions of church (institution and mystical communion) to determine (...) how they consider the choices available within their own tradition that could answer this question. Rather than looking only at the shortcomings of treating magisterial teaching as philosophy, this paper argues that there are also conceptual problems that these courses must address in order to improve their ecclesiological adequacy, and illustrates how an apparent null curriculum privileges the institutional ecclesiology. (shrink)

"This innovative volume argues that any particular kind of music can only be understood in terms of the criteria of the group which makes and appreciates that music. This theme is in sharp contrast to established attitudes to music which utilize 'objectively' conceived aesthetic. These attitudes are revealed in the assumptions underlying most musicology and musical aesthetics including, perhaps paradoxically, the work of a number of cultural radicals such as Lukacs and Adorno. On a more practical level, they manifest themselves (...) both in music education policies and in the policies of arts and broadcasting administrators, who have the power to promote some kinds of music above others. (shrink)

Constraints on the types of speech errors observed can be accounted for by a frame/content distinction, but connectionist modeling shows that they do not require this distinction. The constraints may arise instead from the statistical properties of our language, in particular, the sequential biases observed in the vocabulary. Nevertheless, there might still be a role for the frame/content distinction in syntactic planning.

This paper considers the claim that imagination is implicated in our most apparently straightforward human transactions with the world, that our 'knowing' of the world (both in experience and our subsequent symbolic ordering of it) is in some sense imaginatively constructed from the outset. Second, drawing in particular on the work of Mark Johnson, it explores the senses in which such imaginative transactions are both experience constituted and experience constitutive (that, in Ricoeur's words, imagination 'invents in both senses of the (...) word'). Third, it attends to one apparent theological cost of ascribing to human imagination a 'creative' role in relation to the human world. Fourth, it focuses in particular on Charles Taylor's account of the imaginative construction of the self as a moral entity. And finally, it considers just one example of how the arts may be active in shaping moral identity, and thereby the human world in which we live and move and have our being. (shrink)

The Problem of Consciousness This chapter will introduce you to consciousness and its most important characteristics. We will look at definitions of consciousness, and examine what it means to say that consciousness is a private experience. We will look at the idea that it is like something to be you or me. The chapter mentions ideas and themes that will be covered in more detail in the rest of the book, and explains why the topic is an important one. Research (...) on consciousness is big on questions but shorter on answers. Nevertheless these questions are central to what it means to be human, or indeed at the heart of what it's like to be anything - what it's like to be conscious. Think of yourself just now. What does it feel like you to be you right at this moment? Think of a loved one. What do you think it is like to be them? Do they know exactly what they're feeling, and do you know just what they're feeling? We might have some idea, but the answer in both cases is no, and not only "no", we can't see how we ever could know for sure. It's my consciousness and your consciousness. (shrink)

I examine four core aspects of WEAVER ++. The necessity for lemmas is often overstated. A model can incorporate interaction between levels without feedback connections between them. There is some evidence supporting the absence of inhibition in the model. Connectionist modelling avoids the necessity of a nondecompositional semantics apparently required by the hypernym problem.

We present one of the first quantitative studies on auditory verbal experiences and auditory verbal agency voices or characters”) in healthy participants across states of consciousness. Tools of quantitative linguistic analysis were used to measure participants’ implicit knowledge of auditory verbal experiences and auditory verbal agencies, displayed in mentation reports from four different states. Analysis was conducted on a total of 569 mentation reports from rapid eye movement sleep, non-REM sleep, sleep onset, and waking. Physiology was controlled with the nightcap (...) sleep–wake mentation monitoring system. Sleep-onset hallucinations, traditionally at the focus of scientific attention on auditory verbal hallucinations, showed the lowest degree of VE and VA, whereas REM sleep showed the highest degrees. Degrees of different linguistic-pragmatic aspects of VE and VA likewise depend on the physiological states. The quantity and pragmatics of VE and VA are a function of the physiologically distinct state of consciousness in which they are conceived. (shrink)

We present one of the first quantitative studies on auditory verbal experiences (“hearing voices”) and auditory verbal agency (inner speech, and specifically “talking to (imaginary) voices or characters”) in healthy participants across states of consciousness. Tools of quantitative linguistic analysis were used to measure participants’ implicit knowledge of auditory verbal experiences (VE) and auditory verbal agencies (VA), displayed in mentation reports from four different states. Analysis was conducted on a total of 569 mentation reports from rapid eye movement (REM) sleep, (...) non‐REM sleep, sleep onset, and waking. Physiology was controlled with the nightcap sleep–wake mentation monitoring system. Sleep‐onset hallucinations, traditionally at the focus of scientific attention on auditory verbal hallucinations, showed the lowest degree of VE and VA, whereas REM sleep showed the highest degrees. Degrees of different linguistic‐pragmatic aspects of VE and VA likewise depend on the physiological states. The quantity and pragmatics of VE and VA are a function of the physiologically distinct state of consciousness in which they are conceived. (shrink)

The history of the Euclidean Steiner tree problem, which is the problem of constructing a shortest possible network interconnecting a set of given points in the Euclidean plane, goes back to Gergonne in the early nineteenth century. We present a detailed account of the mathematical contributions of some of the earliest papers on the Euclidean Steiner tree problem. Furthermore, we link these initial contributions with results from the recent literature on the problem.

2000 Years and Beyond brings together some of the most eminent thinkers of our time - specialists in philosophy, theology, anthropology and cultural theory. In a horizon-scanning work, they look backwards and forwards to explore what links us to the matrix of the Judaeo-Christian tradition from which Western cultural identity has evolved. Their plural reflections raise searching questions about how we move from past to future - and about who 'we' are. What do the catastrophes of the twentieth century signify (...) for hopes of progress? Can post - Enlightment humanism and its notion of human nature survive without faith? If the 'numinous magic global capitalism' is our own giant shadow cast abroad, does that shadow offer hope enough of a communal future? Has the modern, secularized West now outgrown its originating faith matrix? Often controversial and sometimes visionary, these seven new essays ask: how do we tell - and rewrite - the story of the Common Era? Introduced by Paul Gifford, and discussed in a lively dialogic conclusion, they add their distinctive voices to a debate of profound and urgent topicality. (shrink)

A principle that many have found attractive is one that goes by the name “'Ought' Implies 'Can'.” According to this principle, one morally ought to do something only if one can do it. This essay has two goals: to show that the principle is false and to undermine the motivations that have been offered for it. Toward the end, a proposal about moral obligation according to which something like a restricted version of 'Ought' Implies 'Can' is true is floated. Though (...) no full-fledged argument for this proposal is offered, that it fits with a rather natural and intuitive picture of the structure of morality and seems to explain certain salient features of the debate over whether the principle is true, goes some way toward recommending it. (shrink)

This paper critically examines several game theoretic interpretations of Hobbes' state of nature, including Prisoner's Dilemma and Assurance Game, and argues instead that the best matrix is that of a combination of the two, an Assurance Dilemma. This move is motivated by the fact that Hobbes explicitly notes two distinct personality types, with different preference structures, in the state of nature: dominators and moderates. The former play as if in a Prisoner's Dilemma, the latter play as if in an Assurance (...) Game. But when meeting one another, the Assurance Dilemma represents their differing strategies, and can explain various other features of Hobbes' state of nature, as well as a key informational role played the Sovereign. (shrink)

Counterfactuals are context-sensitive. However, we argue that various debates and doctrines in metaphysics and the philosophy of science are premised on ignoring the full extent of counterfactual context-sensitivity. Our focus is on the prominent "miracle" versus "no-miracle" debate about counterfactuals under the assumption that our laws of nature are deterministic. But we also discuss doctrines that employ counterfactuals in theories of rational decision, as well as doctrines that explain what it is to be a law of nature in terms of (...) counterfactuals. We conclude by drawing some morals about the use of counterfactuals in philosophical theorizing more generally. (shrink)

Understanding and managing trust is a critical competency for organisations that take their ethical values seriously. Organisations need to know how trust is won, developed and sustained, and also what to do when that trust is threatened or has broken down. This Report helps organisations understand what trust is and how it is established at the interpersonal and organisational level. It outlines strategies for building and sustaining a resilient reputation for organisational trustworthiness and, through the use of case studies, illustrates (...) good and poor practice in repairing internal trust after an organisational failure. (shrink)

This a general account of the school of Mo-tzu, its social basis as a movement of craftsmen, its isolated place in the Chinese tradition, and the nature of its later contributions to logic, ethics, and science. It assesses the relation of Mohist thinking to the structure of the Chinese language, and grapples with the textual dynamics of later Mohist writings, particularly in regard to grammar and style, technical terminology, the use and significance of stock examples, and overall organization. Includes edited (...) and annotated Chinese text with an English translation and commentary, a glossary, and a photographic reproduction of the unemended text from the Taoist Patrology. (shrink)

Graham Priest presents an original exploration of philosophical questions concerning the one and the many. He covers a wide range of issues in metaphysics--including unity, identity, grounding, mereology, universals, being, intentionality, and nothingness--and deploys the techniques of paraconsistent logic in order to offer a radically new treatment of unity. Priest brings together traditions of Western and Asian thought that are usually kept separate in academic philosophy: he draws on ideas from Plato, Heidegger, and Nagarjuna, among other philosophers.

G. E. M. Anscombe’s Intention, meticulous in its detail and its structure, ends on a puzzling note. At its conclusion, Anscombe claims that when he denied Jesus, St. Peter intentionally did what he intended not to do. This essay will examine why Anscombe construes the case as she does and what it might teach us about the nature of practical rationality.

Originally published in 1980, this book examines the major issues in the philosophy of social science, paying specific attention to cross-cultural understanding, humanism versus scientism, individualism versus collectivism, and the shaping of theory by evaluative commitment. Arguing for a cross-cultural conception of human beings, the authors defend humanism and individualism, and reject the notion that social inquiry is necessarily vitiated by an adherence to values.

Standard sorites paradoxes can always be put into a simple canonical form, employing the sole inference modus ponens. For example, consider the following paradox. Take a continuum of colours going from red to blue, and let a1,..., am be a sequence of segments of this continuum such that each segment is phenomenologically indistinguishable in colour from its immediate neighbours. Let Fx be the predicate ‘x is red’. Then the untrue conclusion Fam can be inferred from the premises Fa0 and Fan (...) → Fan + 1. (shrink)

There is a growing interest in how people conceptualise the legal domain for the purpose of legal knowledge systems. In this paper we discuss four such conceptualisations (referred to as ontologies): McCarty's language for legal discourse, Stamper's norma formalism, Valente's functional ontology of law, and the ontology of Van Kralingen and Visser. We present criteria for a comparison of the ontologies and discuss the strengths and weaknesses of the ontologies in relation to these criteria. Moreover, we critically review the criteria.

Martin Heidegger is famous for his early analysis of tools, and equally famous for his later reflections on technology. This might suggest an easy literal reading of these themes in his work along the following lines: ‘Heidegger began his career fascinated by low-tech hardware such as hammers and drills, but later took an interest in advanced devices such as hydroelectric dams’. But such a literal interpretation would miss the point, since neither Heidegger's tool analysis nor his views on technology are (...) limited to a narrow range of specific kinds of entities. When he speaks of ‘tools’, his analysis holds for trees and monkeys no less than for hammers; when he speaks of ‘technology’, he has little to tell... (shrink)

In recent years, many people writing on set theory have invoked the notion of an indefinitely extensible concept. The notion, it is usually claimed, plays an important role in solving the paradoxes of absolute infinity. It is not clear, however, how the notion should be formulated in a coherent way, since it appears to run into a number of problems concerning, for example, unrestricted quantification. In fact, the notion makes perfectly good sense if one endorses a dialetheic solution to the (...) paradoxes. It then morphs from a supposed solution to the paradoxes into a diagnosis of their structure. In this paper I show how. (shrink)

This paper concerns two paradoxes involving propositions. The first is Russell's paradox from Appendix B of The Principles of Mathematics, a version of which was later given by Myhill. The second is a paradox in the framework of possible worlds, given by Kaplan. This paper shows a number of things about these paradoxes. First, we will see that, though the Russell/myhill paradox and the Kaplan paradox might appear somewhat different, they are really just variants of the same phenomenon. Though they (...) do this in different ways, the core of each paradox is to use the notion of a proposition to construct a function, f, from the power set of some set into the set itself. Next we will see how this paradox fits into the Inclosure Schema. Finally, I will provide a model of the paradox in question, showing its results to be non‐trivial, though inconsistent. (shrink)

This paper discusses the major theme of Adrian Moore’s The Evolution of Modern Metaphysics. Moore argues that the philosophical theories of many modern Western philosophers, seen as the project of making sense of the world—in the most general sense of that notion—lead to self-referential contradiction. I agree with him. Moore takes this as a sign that this project requires the need of some non-propositional notion of making sense. Contrary to this, I argue (as in Beyond the Limits of Thought) that (...) it simply indicates the dialetheias at the limits of the project. (shrink)

In this book, Graham Mayeda demonstrates how Watsuji Tetsuro and Kuki Shuzo, two twentieth-century Japanese philosophers, criticize and interpret Heideggerian philosophy, articulating traditional Japanese ethics in a modern idiom.

In this book, Graham Mayeda demonstrates how Watsuji Tetsuro and Kuki Shuzo, two twentieth-century Japanese philosophers, criticize and interpret Heideggerian philosophy, articulating traditional Japanese ethics in a modern idiom.