La tension problématique du concept de Gestalt dans la première pensée de l’art de Heidegger indique une autre provenance que celle, implicitement reconnue par Heidegger, de Nietzsche. La première interprétation du schématisme kantien programme le dépassement phénoménologique de sa dissimulation comme « art caché ». Cette phénoménologie de la temporalité originaire, formulée en termes de « schèmes horizontaux », révèle l’échec de ce dépassement, lié à celui de la Seinsfrage. La collusion entre le problème de la liberté et celui du (...) schématisme se résout, au-delà du phénoménologique, dans le motif de la figure, nous conduisant à voir dans le retrait du schématisme un « impensé » de Heidegger, auquel il aura répondu par une surdétermination « onto-typologique » de la finitude du figural.The problematical tenseness of the concept of Gestalt in Heidegger’s first philosophy of art indicates another source than Nietzsche’s influence, which was implicitly recognized by Heidegger. The first interpretation of Kant’s schematism programs a phenomenological overstepping of its dissimulation as « hidden art ». Such a phenomenology of original temporality, formulated in terms of « horizontal schemas », shows the stumble of this overstepping, related to that of « the question of being ». The connexion between the problematics of freedom and of schematism finds a resolution, beyond phenomenology, in the motif of the figure, leading us to see the withdrawal of schematism as an « unthought », to which Heidegger responded by « onto-typological » overdetermination of the finitude of figurality. (shrink)

Ecological communities around the world are under threat while a consensus theory of community structure remains elusive. In the last decade ecologists have struggled with two seemingly opposing theories: niche-based theory that explains diversity with species’ differences and the neutral theory of biodiversity that claims that much of the diversity we observe can be explained without explicitly invoking species’ differences. Although ecologists are increasingly attempting to reconcile these two theories, there is still much resistance against the neutral theory of biodiversity. (...) Here we argue that the dispute between the two theories is a classic example of the dichotomy between philosophical perspectives, realism and instrumentalism. Realism is associated with specific, small-scale and detailed explanations, whereas instrumentalism is linked to general, large-scale, but less precise accounts. Recognizing this will help ecologists get both niche-based and neutral theories in perspective as useful tools for understanding biodiversity patterns. (shrink)

Background: This study investigated the factors affecting the acceptability in France of abortions. Method: 80 study participants from Toulouse and 124 from Metz judged the acceptability of abortion in 64 vignettes composed of five factors: 1) the adolescent's age (15 or 17.5 years), 2) the adolescent's plans to continue schooling or not, 3) the fetus' age (1, 2, 3, or 4 months), 4) the adolescent's parents' agreement or not, and 5) the agreement or not of baby's father. Results: Three clusters (...) were noted: 1) abortion is never acceptable (8% of participants), 2) abortion is always acceptable (23%), and 3) acceptability of abortion depends on the circumstances (63%). In the majority cluster (3), all five factors had significant effects, but the fetus's age accounted for most of the variance (78%). Conclusion: Most subjects in this study judged, in accordance with French law, that the acceptability of induced abortion in minors depends on the circumstances and, in particular, on the fetus' age. (shrink)

Aim To explore the way people living with HIV and healthcare providers in Togo judge the priority of HIV-infected patients regarding the allocation of antiretroviral drugs. Method From June to September 2015, 200 adults living with HIV and 121 healthcare providers living in Togo were recruited for the study. They were presented with stories of a few lines depicting the situation of an HIV-infected patient and were instructed to judge the extent to which the patient should be given priority for (...) antiretroviral drugs. The stories were composed by systematically varying the levels of four factors: the severity of HIV infection, the financial situation of the patient, the patient's family responsibilities and the time elapsed since the first consultation. Results Five clusters were identified: 65% of the participants expressed the view that patients who are poor and severely sick should be treated as a priority, 13% prioritised treatment of patients who are poor and parents of small children, 12% expressed the view that the poor should be treated as a priority, 4% preferred that the sickest be treated as a priority and 6% wanted all patients to get treatment. Conclusions WHO's guideline regarding antiretroviral therapy allocation currently in use in many African countries does not reflect the preferences of Togolese people living with HIV. For most HIV-infected patients in Togo, patients who cannot get treatment on their own should be treated as a priority. (shrink)

AimTo examine the views of Guinean lay people and healthcare providers regarding the acceptability of HCPs’ refusal to provide care to Ebola patients.MethodFrom October to December 2015, lay people and HCPs in Conakry, Guinea, were presented with 54 sample case scenarios depicting a HCP who refuses to provide care to Ebola patients and were instructed to rate the extent to which this HCP’s decision is morally acceptable. The scenarios were composed by systematically varying the levels of four factors: the risk (...) of getting infected, the HCP’s working conditions, the HCP’s family responsibilities and the HCP’s professional status.ResultsFive clusters were identified: 18% of the participants expressed the view that HCPs have an unlimited obligation to provide care to Ebola patients; 38% held that HCPs’ duty to care is a function of HCPs’ working conditions; 9% based their judgments on a combination of risk level, family responsibilities and working conditions; 23% considered that HCPs do not have an obligation to provide care and 12% did not take a position.ConclusionOnly a small minority of Guinean lay people and HCPs consider that HCPs’ refusal to provide care to Ebola patients is always unacceptable. The most commonly endorsed position is that HCPs’ duty to provide care to Ebola patients is linked to society’s reciprocal duty to provide them with the working conditions needed to fulfil their professional duty. (shrink)

Aim To study the views on the acceptability of physician-assisted-suicide of lay people and health professionals in an African country, Togo.Method In February–June 2012, 312 lay people and 198 health professionals in Togo judged the acceptability of PAS in 36 concrete scenarios composed of all combinations of four factors: the patient's age, the level of incurability of the illness, the type of suffering and the patient's request for PAS. In all scenarios, the patients were women receiving the best possible care. (...) The ratings were subjected to cluster analysis and analyses of variance.Results Most lay people were not systematically opposed to PAS, whereas most health professionals were systematically opposed to it. The most important factors in increasing acceptability among people not systematically opposed were advanced age of the patient and incurability of the illness. Additional acceptability was provided by the patient's request to have her life ended, although much less so than in studies in Western countries, and by suffering characterised by complete dependence rather than by extreme physical pain.Conclusions These empirical findings—the first ones gathered in the African continent—suggest that most Togolese lay people are not categorically for or against PAS, but judge its degree of acceptability as a function of concrete circumstances. (shrink)

The way Cambodian patients and health professionals judge the priority of HIV-infected patients in relation to the allocation of antiretroviral drugs was examined. Participants were either HIV-infected patients attending the HIV/AIDS Care and Support Centre for People Living with HIV/AIDS in Phnom Penh (29 females and 21 males) or members of the staff (9 physicians, 6 pharmacists and 15 health counsellors and health educators). They were presented with stories of a few lines depicting a patient's situation and were instructed to (...) judge the extent to which the patient should be given priority for HIV drugs. The stories were composed according to a four within-subject factor design: (a) the patient's family responsibilities, (b) the severity of infection, (c) the time elapsed since the first consultation, and (d) the financial difficulties of the family. Most patients expressed the view that the drugs should be used for the patients who are most important from a familial point of view, namely, when the family contains small children and/or is already in a precarious financial condition. (shrink)

Background: This study investigated the factors affecting the acceptability in France of abortions. Method: 80 study participants from Toulouse and 124 from Metz judged the acceptability of abortion in 64 vignettes composed of five factors: 1) the adolescent's age (15 or 17.5 years), 2) the adolescent's plans to continue schooling or not, 3) the fetus' age (1, 2, 3, or 4 months), 4) the adolescent's parents' agreement or not, and 5) the agreement or not of baby's father. Results: Three clusters (...) were noted: 1) abortion is never acceptable (8% of participants), 2) abortion is always acceptable (23%), and 3) acceptability of abortion depends on the circumstances (63%). In the majority cluster (3), all five factors had significant effects, but the fetus's age accounted for most of the variance (78%). Conclusion: Most subjects in this study judged, in accordance with French law, that the acceptability of induced abortion in minors depends on the circumstances and, in particular, on the fetus' age. (shrink)

The way people at the receiving end of humanitarian assistance perceive this intervention may provide invaluable bottom-up feedback to improve the quality of the intervention. We analyzed and mapped Haitians’ views regarding international humanitarian aid in cases of natural disaster. Two hundred fifty participants–137 women and 113 men aged 18-67–who had suffered from the consequences of the earthquake in 2010 were presented with a series of vignettes depicting a humanitarian team's action and were asked to what extent these actions corresponded (...) to what ought to be expected from an international aid mission. Four factors were considered in the vignettes whether the team worked in close association with local institutions, whether it was composed of competent people who were prepared for their mission, whether they treated people as a function of immediate needs, and whether they behaved in a respectful way. Through cluster analysis, five qualitatively different positions were found: Complete hostility to any kind of humanitarian aid ; Strong hostility to humanitarian aid in the case of disrespectful attitudes or behaviors ; Technical competence is the only factor that matters ; Both manifestation of respect for the population and technical competence matter and Undetermined. Most Haitians expect humanitarian teams to be technically competent, but even very competent aid is not considered adequate if provided in an arrogant and disrespectful manner. (shrink)

Étienne Pouliot | Résumé : On convient aisément que tout témoignage peut renvoyer à une expérience, passée ou du moins présupposée, ou encore qu’il peut véhiculer en quelque sorte un message. Il ne se réduit pas pour autant à n’être qu’une fenêtre sur autre chose, voire sur lui-même. En vérité, parce qu’il est avant tout parole, le témoignage constitue toujours et se constitue précisément en un certain ratage de l’expérience là représentée, du message là livré, du vécu là offert. Un (...) examen de certaines conditions épistémologiques de cet enjeu de la représentation au coeur du témoignage, en écho à la philosophie de Paul Ricoeur mais pour en signaler le point aveugle, permet d’élucider que cet enjeu y est second — ce qui ne signifie en rien : secondaire — par rapport à un enjeu herméneutique bien plus originaire, bien plus radical et fondamental que la représentation elle-même : celui de la parole. Au travers du témoignage, une parole atteste autant qu’elle efface. |: We all agree that witnessing may refer back to experience — to something from the past or at least to something that is presupposed — or that it may be the vehicle for some message. This does not mean that witnessing is merely a window onto something else, or onto itself. Indeed, because it is first and foremost “word”, it always stands as a reminder of its inability to represent what it purports to represent and as a failure to deliver the message it intends to deliver. This examination of some of the epistemological underpinnings of representation — which echoes the philosophy of Paul Ricoeur even as it points to a blind spot in his position — intends to show that the issue of representation comes second in witnessing and that a far more radical and fundamental issue — a hermeneutical one — also comes into play here. Thus witnessing, and more precisely the word that is witnessing, both attests to and obliterates itself. (shrink)

The views on the acceptability of physician-assisted suicide of lay people in a Latin American country, Colombia, have been examined. In July 2019–January 2020, 134 lay people in Bogota judged the acceptability of physician-assisted suicide in 48 realistic scenarios composed of all combinations of four factors: the patient's age, the level of incurability of the illness, the type of suffering, and the patient's request for physician-assisted suicide. In all scenarios, the patients were women receiving the best possible care. The ratings (...) were subjected to cluster analysis and analyses of variance. Three qualitatively different positions were found: Never Acceptable, Depends on the Patient's Request, and Always Acceptable. The only important factor in increasing acceptability among people not systematically opposed was the patient's request to have her life ended. The young age of some patients did not affect participants’ positions. These empirical findings suggest that most Colombian lay people are not categorically for or against physician-assisted suicide, but judge its degree of acceptability as a function of patients’ requests and other circumstances. (shrink)

Les archives, bien que fondamentales dans la pratique des historiens, tiennent une faible place dans leur réflexion épistémologique, alors que la notion, employée le plus souvent au singulier, a été davantage analysée par certains philosophes, dont en dernier lieu Paul Ricoeur. Il s'agira donc de comprendre l'usage que ce dernier fait du concept d'archive dans son dernier ouvrage, La Mémoire, l'histoire, l'oubli, puis de montrer sa filiation avec les travaux de Michel Foucault et de Michel de Certeau. Enfin, on (...) voudrait montrer en quoi cette« archive», liée intimement à la notion de témoignage, peut conduire à des difficultés du point de vue de l'épistémologie historique, et qu'il semble possible de lui opposer un autre usage de la notion, soucieux d'en souligner l'historicité et la matérialité face à une interprétation plus textuelle et herméneutique. (shrink)

Cet essai n’a pas d’autre prétention que de proposer une périodisation de l’histoire du catholicisme, en France surtout, mais aussi en Europe occidentale au cours du dernier demi-siècle. Sur fond de sécularisation et de laïcisation plus ou moins poussées, il a connu quatre phases bien différentes: au malaise suscité par le raidissement de la fin du pontificat de Pie XII a succédé une brève euphorie née du concile Vatican II. Mais celle-ci n’a pas duré, battue en brèche par la crise (...) de civilisation des «années 68» et les difficultés d’application des textes conciliaires. La double contestation traditionaliste et progressiste a nourri la «crise catholique» des années 1970. Dans des styles différents, Paul VI, Jean-Paul II et Benoît XVI se sont efforcés de la conjurer par la restauration d’une Église prudemment réformée et accueillante aux nouveaux courants spirituels. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:IS GOD ESSENTIALLY DIFFERENT FROM HIS CREATURES? RAHNER'S EXPLANATION FROM REVELATION INTRODUCTION IN THIS PAPER we shall discuss two questions concerning the doctrine of God in the theology of Karl Rahner. What is it? On what is it based? In the process, we shall critically examine the relationship between the doctrine of God and Rahner's view of Christian revelation, focusing on the nature of theological method. Analysis will proceed (...) in two ways: comparison of Rahner's method with what I see as the method of scripture (faith seeking understanding) and with that of traditional Thomism as represented by Etienne Gilson. In Foundatians of Christian Faith, Chapter ~. "Man in the Presence of Absolute Mystery," Theological Investigations, volume 4, "The Concept of Mystery in Catholic Theology," and Theological ln1Yestigations, volume 11, "The Experience of God Today " Rabner develops his doctrine of God from his concept of absolute mystery which is drawn from human experience of reality according to his transcendental method. This method itself establishes the foundation for answering the first question, as we shall see. In answering the second question it is important that we examine carefully the foundation and determining element for any concept of God and of the creature's relation with God. The following issues will have to be discussed also: the nature of and need for Christian revelation, the role of faith and the kind of relation which exists between the Creator God and creatures. We shall discuss how Rahner deals with the free grace of God's revelation and presence in history while synthesizing creaturely self-tran575 576 PAUL D. MOLNAR scendent experience with grace and revelation according to his transcendental method. Such synthesis perceives the reality of God according to the constructs of natural theology and eliminates any practical need for revelation and faith in the triune God as the only true God. Moreover, we hope to show that the starting point for Rahner's transcendental method [human experience] is the very £actor which causes irreconcilable conflicts for a theology which claims to be a theology based on revelation. Rahner's analysis of experience is profound and has been useful for many in describing the creature's relation with the Creator. But as long as it is thought that our self-transcending experiences provide a point of departure for knowing the true God, Christian theologians will always have difficulty actually distinguishing God from their ideas about Hirn. For scriptural faith the point of departure for knowing the reality of God was and remains God's own free self-manifestation in His historical interventions within the realm of experience. As we shall see, this very point is what Rahner seeks to uphold. But in fact his method causes him to be inconsistent. While he would insist that this historical intervention is what happened in Israel, in Christ and in the Church; his method cannot a11ow him to hold consistently that the only point of departure for knowing the truth about our experiences is the Word of God revealed and active in Christ and the Spirit. Thus, true knowledge of God for Rahner is simultaneously ascribed to the grace of God and to our innate knowledge of absolute being. This claim is actually indebted to the Cartesian method and, as we shall see, it causes logical and theological problems for a theology that claims to be a theology of revelation. Concerning Rahner's doctrine of God, then, we return to the opening questions: What is it? On what is it based? Following Rahner's own outline in Fottndations of Christian Faith these questions can only be answered together by tracing the development of his own logic based upon the transcendental experience of our" horizon." Rahner's doctrine of God begins RAHNER'S EXPLANATION FROM REVELATION 577 from the assumption that an experience of one's "horizon " is an experience of God. And this assumption dictates what it is. Therefore, in Rahner's thought, these two questions cannot in fact be separated. Rahner provides no other foundation for this assumption than the idea that man must think and act in light of this horizon. Instead of pointing beyond the circle of human experience to show us... (shrink)

Entendant " rendre justice au droit ", Paul Ricoeur a placé le lieu propre du juridique à mi-chemin de l'éthique et du politique.Philosophes, linguistes, praticiens du droit, d'autres encore analysent et critiquent dans leur propre champ d'action...

This paper explores the claim made by Thomas Aquinas in Summa Theologiae, I, q. 1, a. 3 that ‘sacred doctrine’ is ‘scientific.’ After reviewing some of the key historical commentators on the question, I propose an examination of Thomas' treatment of the gift of prophecy as providing an important clue into discerning more clearly his evolution from an Aristotelian understanding of knowledge or ‘science’ to a fuller sense of the term scientia as used by Thomas. Chief among these is a (...) clue into how Thomas resolves the difficulty between necessity and history. His treatment of prophecy in the Summa Theologiae gives one a glimpse into how Thomas is a historical thinker, despite weighty authorities such as Etienne Gilson arguing otherwise. Closer attention to prophecy permits one to rethink Thomas' account of sacred doctrine in Question One and appreciate how pivotal the fact of divine revelation having been made to prophets in history is for its ‘scientific’ character. (shrink)

The writings of the French Marxist philosopher Louis Althusser and his associates have figured prominently in the development of contemporary social theory. The Althusserian school of Structural Marxism is a startlingly original synthesis of Marxism and Modernism, which has produced a large body of work that extends across the human sciences and the humanities to engage a wide variety of cultures, theoretical problems, and political issues. Despite the fact that Althusser himself is widely recognized as a major figure, the breadth, (...) coherence, and achievements of Structural Marxism as a whole have gone largely unrecognized. In this, the most systematic and wide-ranging assessment of Structural Marxism in any language, Resch provides a comprehensive and thematic introduction to the work of Althusser, Nicos Poulantzas, Pierre Macherey, Etienne Balibar, Emmanuel Terray, Terry Eagleton, Göran Therborn, Renée Balibar, Perry Anderson, Pierre-Philippe Rey, Michel Pêchaux, Guy Bois, and others. Resch's sympathetic and critical study demonstrates the enormous significance of Althusser's modernist renewal of Marxist social theory and its ongoing challenge to post-Marxist movements such as postmodernism and neo-liberalism. (shrink)

This study undertakes a reading of Etienne de La Boétie’s Discours de la servitude volontaire, endeavoring to bring to light the way it convergences with and diverges from the political thought of Paul Ricœur, around the central concept of the will. On the basis of the twin notions of “denaturation” and of “pathology,” a course unfolds which aims at helping establish the people, in comparison with the institution of the State, through a political process revitalised by friendship. But (...) the two thinkers differ when it comes to the resources of the will. This is reflected in the notion of freedom, conceived as absolute in La Boetie, while Ricœur emphasizes its contingency, which leads him to thematize it in terms of capabilities. (shrink)

: In this paper, the author will demarcate three main stages of the development of Étienne Gilson’s doctrine on Christian philosophy through an examination of some of Gilson’s key works, treated in chronological order. Thus, he proceeds to explicate how Gilson’s doctrine developed from its gestational stage in the 1920s through the first Christian philosophy debate of the 1930s, into its 2nd stage of birth and infancy from the 1930s through the early 1950s, ending with the 3rd stage of maturity (...) in the later 1950s and 1960s. Furthermore, he notes that implicit throughout those three stages are notions of Christian philosophy as existing in two modes: one as the philosophical component present within theology and the second properly speaking outside of theology though by no means outside of the influence of Christianity. Additionally, Gilson’s influence upon St. John Paul II’s treatment of Christian philosophy in Fides et Ratio is addressed. The paper culminates in showing how Gilson’s mature doctrine on Christian philosophy is relevant as a guide for doing Christian philosophy in this Third Christian Millennium. (shrink)

Being questioned about the nature of Christian faith, Mark Twain famously declared it as 'believing what you know ain't so'. Indeed, the role of reason for faith is a matter of dispute. Jesus, some argue, was not a philosopher or a teacher of wisdom. Rather, he is the saviour because of his unassuming sacrificial death and resurrection. Not reason, but the leap of faith is the ultimate condition of salvation. The Enlightenment however epitomises a Copernican revolution in favour of reason. (...) According to Charles Taylor, the dissemination of Jesus' message into Hellenistic culture contains within itself the risk of a secularisation of the faith. At the same time, voices opposing the overemphasis of reason have also been raised throughout the ages. Paul's speech to the Athenians was one such occasion that deals with the ambiguous relationship between faith and reason. Relying purely on divine grace and the Bible alone, Martin Luther rejected any form of speculative theology. According to the Reformer, it is a type of theology that trusts more in human reason than in God's revelation. In Luther's opinion, it also reverses the moral order because theological speculation justifies evil as good while professing as good what is evil. To such a theology of human glory, Luther prefers a theology of the cross that 'calls the thing what it actually is'. For the former Augustinian monk only God's grace is good beyond reasonable doubt. Hence true theologians are lovers of the cross while theologians of glory misuse their reason for the worst. Luther's theology of the cross, Marco Barone claims, has its root in Augustine. Hence, Luther's Augustinism appears to have decidedly broken with Aristotelian scholasticism. In this context, Thomas Aquinas was criticised for his threefold failure. First, the Dominican friar's speculative theology lacks an experiential human dimension. Secondly, it gives too much credit to Aristotle. Thirdly, Thomas is reprimanded for his serious deficiency of a theology of justification. (shrink)

Si l'histoire de la pensee medievale inclut celle de ses influences, comme l'histoire de la pensee moderne celle de ses sources, il est alors doublement legitime de se demander ce que peut nous apprendre sur la pensee cartesienne sa confrontation historique avec la pensee medievale, au contact de laquelle elle s'est formee, et a l'encontre de laquelle elle s'est developpee. Prenant la suite de travaux anterieurs, cet ouvrage d'Etienne Gilson envisage tout d'abord la confrontation dans une perspective genetique (en (...) cherchant dans certaines doctrines medievales les sources de theses cartesiennes comme l'inneisme, l'etude des meteores ou de la circulation sanguine), avant de considerer plus precisement le rapport de la metaphysique cartesienne et de la metaphysique medievale a travers l'examen de certains points de doctrine particulierement delicats. C'est ici notamment que sont rencontres et eclaircis les problemes de la critique cartesienne des formes substantielles, du dialogue de Descartes avec saint Augustin a l'occasion du cogito, avec saint Thomas dans la preuve de l'existence de Dieu par la causalite de l'idee, et avec saint Anselme dans la preuve dite ontologique. Le caractere novateur de la pensee cartesienne se trouve ainsi etabli avec une acuite inedite. (shrink)

In this final edition of his classic study of St. Thomas Aquinas, Etienne Gilson presents the sweeping range and organic unity of Thomistic philosophical thought. The philosophical thinking of Aquinas is the result of reason being challenged to relate to many theological conceptions of the Christian tradition. Gilson carefully reviews how Aquinas grapples with the relation itself of faith and reason and continuing through the existence and nature of God and His creation, the world and its creatures, especially human (...) beings with their power of intellect, will, and moral life. He concludes this study by discussing the life of people in society, along with their purpose and final destiny. Gilson demonstrates that Aquinas drew from a wide spectrum of sources in the development of his thought-from the speculations of the ancient Greeks such as Aristotle, to the Arabic and Jewish philosophers of his time, as well as from Christian writers and scripture. The Christian Philosophy of St. Thomas Aquinas offers students of philosophy and medieval studies an insightful introduction to the thought of Aquinas and the Scholastic philosophy of the Middles Ages, insights that are still revelant for today. (shrink)

Despite clinical evidence of drug superiority, therapeutic modalities, like combination immunotherapy, are mostly considered cost-ineffective due to their high costs per life year(s) gained. This paper, taking an ethical stand, reevaluates the standard cost-effectiveness analysis with that of the more recent justice-enhanced methods and concludes by pointing out the shortcomings of the current methodologies.

Abstract3′ untranslated regions (3′ UTRs) of mRNAs have many functions, including mRNA processing and transport, translational regulation, and mRNA degradation and stability. These different functions require cis‐elements in 3′ UTRs that can be either sequence motifs or RNA structures. Here we review the role of secondary structures in the functioning of 3′ UTRs and discuss some of the trans‐acting factors that interact with these secondary structures in eukaryotic organisms. We propose potential participation of 3′‐UTR secondary structures in cytoplasmic polyadenylation in (...) the model organism Drosophila melanogaster. Because the secondary structures of 3′ UTRs are essential for post‐transcriptional regulation of gene expression, their disruption leads to a wide range of disorders, including cancer and cardiovascular diseases. Trans‐acting factors, such as STAU1 and nucleolin, which interact with 3′‐UTR secondary structures of target transcripts, influence the pathogenesis of neurodegenerative diseases and tumor metastasis, suggesting that they are possible therapeutic targets. (shrink)

Dans sa these de 1913, La liberte chez Descartes et la theologie, Etienne Gilson inaugure le geste qu'il prolongera dans l'Index scolastico-cartesien et les Etudes sur le role de la pensee medievale dans la formation du systeme cartesien: situer l'oeuvre de Descartes dans le contexte intellectuel de son epoque. S'il est certain qu'avec Descartes la philosophie tout entiere semble prendre un nouveau depart, il n'en est pas moins sur que cette pensee s'est formee sous l'influence de la theologie scolastique (...) a laquelle Descartes fut initie lors de ses etudes chez les Jesuites. Etienne Gilson se propose ainsi d'eclairer de cette influence les definitions cartesiennes de la liberte. Notion cardinale de sa philosophie, la liberte fut en effet, avant Descartes, l'objet de nombreuses reflexions theologiques: elle se presente donc comme le point de rencontre privilegie de ces deux systemes de pensee. Par cette entree dans l'oeuvre de Descartes, Etienne Gilson nous invite a la lire d'un oeil neuf: c'est ainsi qu'il nous permet, par exemple, de deplacer le coeur de l'apport cartesien de la definition de la liberte humaine (pour laquelle il emprunte beaucoup aux grands penseurs scolastiques) a celle de la liberte divine. Des lors, Descartes se revele plus fidele a la tradition scolastique qu'il ne l'affirme: n'en transformant les cadres que lorsqu'il s'y trouve contraint par les exigences de sa physique, il s'efforce de minimiser autant que possible les modifications qu'il y applique. (shrink)

L'introduction proposee par Etienne Gilson a l'etude de saint Augustin a pour vocation de cerner l'esprit meme de l'augustinisme en relevant ce qui, dans la doctrine, a imprime a la pensee medievale l'impulsion dont tant d'oeuvres profondes sont les temoins. Cette etude se propose ainsi de degager les quelques theses essentielles qui, commandant l'ensemble de la doctrine, permettent d'en interpreter le detail. La table systematique des matieres annexee a ce volume permettra d'ailleurs au lecteur de l'utiliser a la maniere (...) d'un inventaire; la bibliographie raisonnee competant cette table l'aidera en outre a s'orienter dans une vaste litterature historique. Cependant, a la place de l'ordre synthetique et lineaire des doctrines qui suivent la norme de l'intellect, nous trouvons dans l'augustinisme un mode d'exposition necessairement autre, approprie a une doctrine dont le centre est dans la grace et dans la charite. La methode est digressive: l'ordre naturel de la doctrine augustinienne est ce rayonnement autour d'un centre, qui est l'ordre meme de la charite. Et s'il s'agit la moins de savoir que d'aimer, la tache propre du philosophe est moins de fiare connaitre que de faire desirer... On concoit alors que cet ouvrage, publie pour la premiere fois en 1929, promette aujourd'hui encore une decouverte originale de saint Augustin. (shrink)

When I began working on my dissertation on Kant’s aesthetic theory in 1971, I was able to read virtually all of the extant literature on the Critique of Judgment in English, German, andFrench going back to Hermann Cohen’s Kants Begr¨undung der A¨ sthetik of 1889, while also reading most of what I wanted to read of eighteenth-century British and German aesthetics before Kant—not because I had paid my dues to Evelyn Wood, but just because there was not all that much (...) to read.1 I pity the graduate student who sets out to write a dissertation on the third Critique now: since Donald Crawford, Francis Coleman, Jens Kulenkampff, Eva Schaper, and I published books on Kant’s aesthetics between 1974 and 1979 there has been a continuing flood of articles (this journal receives more submissions on Kant’s aesthetics annually than on any other historical topic) and books, a flood that has only accelerated since 2000. Confining myself only to monographs and anthologies on Kant’s aesthetics or the third Critique as a whole (but not those devoted exclusively to teleology) in English, German, and French on my shelves, and no doubt missing some, at least in German and French, I find twenty-eight monographs and anthologies published in the period between 1980 and 1999 and another twenty-seven just since 2000. (Indeed, two more have arrived on my desk since this article was written.)3 Someone setting out to work on the third Critique now has at least as many books from the last decade alone to read as I had in 1971 from the eight preceding decades. The present review will make only a small dent in this pile: I will discuss just five monographs and one introduction to the third Critique, all published in English in 2006 and 2007. (shrink)

The great philosopher and historian of philosophy, Etienne Gilson, sets out to show that final causality or purposiveness and formal causality are principles for those who think hard and carefully about the world, including the world of biology. Gilson insists that a completely rational understanding of organisms and biological systems requires the philosophical notion of teleology, the idea that certain kinds of things exist and have ends or purposes the fulfillment of which are linked to their natures-in other words, (...) formal and final causes. His approach relies on philosophical reflection on the facts of science, not upon theology or an appeal to religious authorities such as the Church or the Bible. (shrink)