Lower plasma levels of high-density lipoproteins in adolescents with type 2 diabetes have been associated with a higher pulse wave velocity, a marker of arterial stiffness. Evidence suggests that HDL proteins or particle subspecies are altered in T2D and these may drive these relationships. In this work, we set out to reveal any specific proteins and subspecies that are related to arterial stiffness in youth with T2D from proteomics data. Plasma and PWV measurements were previously acquired from lean and T2D (...) adolescents. Each plasma sample was separated into 18 fractions and evaluated by mass spectrometry. Then, we applied a validated network-based computational approach to reveal HDL subspecies associated with PWV. Among 68 detected phospholipid-associated proteins, we found that seven were negatively correlated with PWV, indicating that they may be atheroprotective. Conversely, nine proteins show positive correlation with PWV, suggesting that they may be related to arterial stiffness. Intriguingly, our results demonstrate that apoA-I and histidine-rich glycoprotein may reverse their protective roles and become antagonistic in the setting of T2D. Furthermore, we revealed two arterial stiffness-associated HDL subspecies, each of which contains multiple PWV-related proteins. Correlation and disease association analyses suggest that these HDL subspecies might link T2D to its cardiovascular-related complications. (shrink)

In his preface Mr Wilson writes 'I feel that a great many adults … would do better to spend less time in simply accepting the concepts of others uncritically, and more time in learning how to analyse concepts in general'. Mr Wilson starts by describing the techniques of conceptual analysis. He then gives examples of them in action by composing answers to specific questions and by criticism of quoted passages of argument. Chapter 3 sums up the importance of this kind (...) of mental activity. Chapter 4 presents selections for the reader to analyse, followed by questions of university entrance/scholarship type. This is a book to be worked through, in a sense a text-book. (shrink)

In this philosophically sophisticated and historically significant work, John H. Zammito reconstructs Kant's composition of The Critique of Judgment and reveals that it underwent three major transformations before publication. He shows that Kant not only made his "cognitive" turn, expanding the project from a "Critique of Taste" to a Critique of Judgment but he also made an "ethical" turn. This "ethical" turn was provoked by controversies in German philosophical and religious culture, in particular the writings of Johann Herder and (...) the Sturm und Drang movement in art and science, as well as the related pantheism controversy. Such topicality made the Third Critique pivotal in creating a "Kantian" movement in the 1790s, leading directly to German Idealism and Romanticism. The austerity and grandeur of Kant's philosophical writings sometimes make it hard to recognize them as the products of a historical individual situated in the particular constellation of his time and society. Here Kant emerges as a concrete historical figure struggling to preserve the achievements of cosmopolitan Aufkl-rung against challenges in natural science, religion, and politics in the late 1780s. More specifically Zammito suggests that Kant's Third Critique was animated throughout by a fierce personal rivalry with Herder and by a strong commitment to traditional Christian ideas of God and human moral freedom. "A work of extraordinary erudition. Zammito's study is both comprehensive and novel, connecting Kant's work with the aesthetic and religious controversies of the late eighteenth century. He seems to have read everything. I know of no comparable historical study of Kant's Third Critique."-Arnulf Zweig, translator and editor of Kant's ;IPhilosophical Correspondence, 1759-1799;X "An intricate, subtle, and exciting explanation of how Kant's thinking developed and adjusted to new challenges over the decade from the first edition of the Critique of Pure Reason to the appearance of the Critique of Judgment. "--John W. Burbidge, Review of Metaphysics "There has been for a long time a serious gap in English commentary on Kant's Critique of Judgment Zammito's book finally fills it. All students and scholars of Kant will want to consult it."--Frederick Beiser, Times Literary Supplement. (shrink)

In epistemology, the concept of knowledge is of distinctive interest. This fact is also reflected in the discussion of epistemic value, which focuses to a large extend on the value problem of knowledge. This discussion suggests that knowledge has an outstanding value among epistemic standings because its value exceeds the value of its constitutive parts. I will argue that the value of knowledge is not outstanding by presenting epistemic standings of checking, transferring knowledge, and proving in court, whose values exceed (...) the value of knowledge in certain contexts. Moreover, the values of these other epistemic standings do not always rely on the value of knowledge. In terms of value, knowledge is not an outstanding epistemic concept. Hence, in terms of value we cannot find support for the privileged position that knowledge enjoys in epistemology. (shrink)

This paper provides a thorough analysis of two often informally stated claims. First, successful argumentation in the sense of persuasive argumentation requires agreement between the interlocutors about the rationality of arguments. Second, a general agreement about rationality of arguments cannot itself be established via argumentation, since such an attempt leads to an infinite meta‐regress. Hence, agreement about the rationality of arguments is a precondition for successful argumentation. As the paper argues, these plausible claims hold under the assumption that interlocutors are (...) subjectively rational and follow their own standards of rationality when engaging in argumentation. (shrink)

This article aims to provide a structural analysis of the problems related to the easy knowledge problem. The easy knowledge problem is well known. If we accept that we can have basic knowledge via a source without having any prior knowledge about the reliability or accuracy of this source, then we can acquire knowledge about the reliability or accuracy of this source too easily via information delivered by the source. Rejecting any kind of basic knowledge, however, leads into an infinite (...) regress and, plausibly, to skepticism. The article argues that the third alternative, accepting basic knowledge but rejecting easy knowledge, entails closure failure. This is obviously the case for deductive bootstrapping, but, notably, the problem also arises for inductive bootstrapping. Hence, the set of problems related to the easy knowledge problem has the structure of a trilemma. We are forced to accept easy knowledge, closure failure, or skepticism. (shrink)

That bootstrapping and Moorean reasoning fail to instantiate persuasive argumentation is an often informally presented but not systematically developed view. In this paper, I will argue that this unpersuasiveness is not determined by principles of justification transmission but by two straightforward principles of rationality, understood as a concept of internal coherence. First, it is rational for S to believe the conclusion of an argument because of the argument, only if S believes sufficiently many premises of the argument. Second, if S (...) doubts that a source O is reliable and believes that information i is delivered by O, then S rationally suspends judgment about the truth of i. This paper aims to accomplish two tasks. First, it provides a thorough analysis of why bootstrapping argumentation is not an instance of rational persuasion. Second, it contains a more general theory about preconditions and limits of persuasive argumentation. (shrink)

The proof paradox results from conflicting intuitions concerning different types of fallible evidence in a court of law. We accept fallible individual evidence but reject fallible statistical evidence even when the conditional probability that the defendant is guilty given the evidence is the same, a seeming inconsistency. This paper defends a solution to the proof paradox, building on a sensitivity account of checking and settling a question. The proposed sensitivity account of legal proof not only requires sensitivity simpliciter but sensitivity (...) of each relevant step of the proof procedure and/or sensitivity concerning all relevant alternatives. This account avoids problems that have been identified for other sensitivity views of legal proof. Moreover, it is argued that sensitivity, rather than safety, is the crucial modal condition for legal proof. It is, finally, shown that the provided account can fruitfully support very different existing views on the relationship between knowledge and legal proof. (shrink)

Foreword I. Critical rationalism is a genuinely new philosophical perspective. It is not, however, one systematic view. The development of it by Popper and ...

I argue that incomprehensibility (what the ancient skeptics called acatalepsia) plays a central role in the skepticism of both Bayle and Hume. I challenge a commonly held view (recently argued by Todd Ryan) that Hume, unlike Bayle, does not present oppositions of reason--what Kant called antimonies.

Modal knowledge accounts that are based on standards possible-worlds semantics face well-known problems when it comes to knowledge of necessities. Beliefs in necessities are trivially sensitive and safe and, therefore, trivially constitute knowledge according to these accounts. In this paper, I will first argue that existing solutions to this necessity problem, which accept standard possible-worlds semantics, are unsatisfactory. In order to solve the necessity problem, I will utilize an unorthodox account of counterfactuals, as proposed by Nolan, on which we also (...) consider impossible worlds. Nolan’s account for counterpossibles delivers the intuitively correct result for sensitivity i.e. S’s belief is sensitive in intuitive cases of knowledge of necessities and insensitive in intuitive cases of knowledge failure. However, we acquire the same plausible result for safety only if we reject his strangeness of impossibility condition and accept the modal closeness of impossible worlds. In this case, the necessity problem can be analogously solved for sensitivity and safety. For some, such non-moderate accounts might come at too high a cost. In this respect, sensitivity is better off than safety when it comes to knowing necessities. (shrink)

Everyone loves something or somebody, and most people are concerned with loving another person like themselves, all equal. This book is based on the belief that getting clear about the concept and meaning of love between equals is essential for success in our practical lives. For how can we love properly unless we have a fairly clear idea of what love is? The book is written in ordinary language and for the ordinary person, without jargon or philosophical technicalities. It aims (...) to show that love between equals involves a single basic disposition, though that disposition expresses itself in various ways. Thus, after an introduction explaining the need for analysis and clarification, the author then deals in order with love as desire or need; with intrinsic friendship and sharing the self; with basic difficulties concerning power, dependence, altruism and paranoia; with sex and erotic love; and finally with the value in human life of love between equals. The work as a whole gives clear, coherent and practical guidance for all who wish to grasp what such love is really like. (shrink)

This book is primarily about checking and only derivatively about knowing. Checking is a very common concept for describing a subject’s epistemic goals and actions. Surprisingly, there has been no philosophical attention paid to the notion of checking. In Part I, I develop a sensitivity account of checking. To be more explicit, I analyze the internalist and externalist components of the epistemic action of checking which include the intentions of the checking subject and the necessary externalist features of the method (...) used. Crucially, successfully checking whether p is true requires using a method that is sensitive with respect to p, i.e. a method that would not indicate that p, if p were false. In Part II, I use the distinction between knowing and checking to explain central puzzles about knowledge, particularly puzzles centering on knowledge closure, puzzles concerning bootstrapping and the skeptical puzzle. Moreover, the book clarifies a dispute about modal epistemology, concerning the application of the sensitivity principle. By arguing that sensitivity is necessary for checking but not knowing, I explain where our persisting intuitions about sensitivity have their place in epistemology. (shrink)

This paper provides a reinterpretation of some of the most influential skeptical arguments, Agrippa’s trilemma, meta-regress arguments, and Cartesian external world skepticism. These skeptical arguments are reasonably regarded as unsound arguments about the extent of our knowledge. However, reinterpretations of these arguments tell us something significant about the preconditions and limits of persuasive argumentation. These results contribute to the ongoing debates about the nature and resolvability of deep disagreement. The variety of skeptical arguments shows that we must distinguish different types (...) of deep disagreement. Moreover, the reinterpretation of skeptical arguments elucidates that deep disagreement cannot be resolved via argumentation. (shrink)

The discussion about deep disagreement has gained significant momentum in the last several years. This discussion often relies on the intuition that deep disagreement is, in some sense, rationally irresolvable. In this paper, I will provide a theory of rationally irresolvable disagreement. Such a theory is interesting in its own right, since it conflicts with the view that rational attitudes and procedures are paradigmatic tools for resolving disagreement. Moreover, I will suggest replacing discussions about deep disagreement with an analysis of (...) rationally irresolvable disagreement, since this notion can be more clearly defined than deep disagreement and captures the basic intuitions underlying deep disagreement. I will first motivate this project by critically assessing the current debate about deep disagreement. I then detail the notions of rationality and resolvable disagreement which are crucial for a suitable theory of rationally irresolvable disagreement before sketching various instances of rationally irresolvable disagreement. Finally, I argue for replacing theories of deep disagreement with theories of rationally irresolvable disagreement, an approach that has significant advantages over existing theories of deep disagreement which focus on hinge propositions or fundamental epistemic principles. (shrink)

Discrimination is a central epistemic capacity but typically, theories of discrimination only use discrimination as a vehicle for analyzing knowledge. This paper aims at developing a self-contained theory of discrimination. Internalist theories of discrimination fail since there is no compelling correlation between discriminatory capacities and experiences. Moreover, statistical reliabilist theories are also flawed. Only a modal theory of discrimination is promising. Versions of sensitivity and adherence that take particular alternatives into account provide necessary and sufficient conditions on discrimination. Safety in (...) contrast is not sufficient for discrimination as there are cases of safety that are clearly instances of discrimination failure. The developed account of discrimination between objects will be extended to discrimination between kinds and between types. (shrink)

The orthodox view about sensitivity and induction has it that beliefs formed via induction are insensitive. Since inductive knowledge is highly plausible, this problem is usually regarded as a reductio argument against sensitivity accounts of knowledge. Some adherents of sensitivity defend sensitivity against this objection, for example by considering backtracking interpretations of counterfactuals. All these extant views about sensitivity and induction have to be revised, since the problem of sensitivity and induction is a different one. Regardless of whether we allow (...) backtracking interpretations of counterfactuals, some instances of induction yield insensitive beliefs whereas others yield sensitive ones. These results are too heterogenous for providing a plausible sensitivity-account of inductive knowledge. Induction remains a serious problem for sensitivity accounts of knowledge. (shrink)

Ed. Daniel Greenberger, 750pp May 1995 164.95.

John Webster provides a major scholarly analysis, the first in any language, of the final sections of the Church Dogmatics. He focuses on the theme of human agency in Barth's late ethics and doctrine of baptism, placing the discussion in the context of an interpretation of the Dogmatics as an intrinsically ethical dogmatics. The first two chapters survey the themes of agency, covenant and human reality in the Dogmatics as a whole; later chapters give a thorough analysis of Church (...) Dogmatics IV/4 and the posthumously published text The Christian Life. A final chapter examines the significance of Barth's work for contemporary accounts of moral selfhood. The book is important not only for a detailed analysis of a neglected part of Barth's oeuvre, but also because it casts into question much of what has hitherto been written about Barth's ethical dogmatics. (shrink)

Offering a solution to the skeptical puzzle is a central aim of Nozick's sensitivity account of knowledge. It is well-known that this account faces serious problems. However, because of its simplicity and its explanatory power, the sensitivity principle has remained attractive and has been subject to numerous modifications, leading to a of sensitivity accounts. I will object to these accounts, arguing that sensitivity accounts of knowledge face two problems. First, they deliver a far too heterogeneous picture of higher-level beliefs about (...) the truth or falsity of one's own beliefs. Second, this problem carries over to bootstrapping and Moorean reasoning. Some beliefs formed via bootstrapping or Moorean reasoning are insensitive, but some closely related beliefs in even stronger propositions are sensitive. These heterogeneous results regarding sensitivity do not fit with our intuitions about bootstrapping and Moorean reasoning. Thus, neither Nozick's sensitivity account of knowledge nor any of its modified versions can provide the basis for an argument that bootstrapping and Moorean reasoning are flawed or for an explanation why they seem to be flawed. (shrink)

Modal knowledge accounts like sensitivity or safety face a problem when it comes to knowing propositions that are necessarily true because the modal condition is always fulfilled no matter how random the belief forming method is. Pritchard models the anti-luck condition for knowledge in terms of the modal principle safety. Thus, his anti-luck epistemology faces the same problem when it comes to logical necessities. Any belief in a proposition that is necessarily true fulfills the anti-luck condition and, therefore, qualifies as (...) knowledge. Miščević shares Pritchard’s take on epistemic luck and acknowledges the resulting problem. In his intriguing article “Armchair Luck: Apriority, Intellection and Epistemic Luck” Miščević suggests solving the problem by supplementing safety with a virtue theoretic condition-“agent stability”-which he also spells out in modal terms. I will argue that Miščević is on the right track when he suggests adding a virtue-theoretic component to the safety condition. However, it should not be specified modally but rather in terms of performances that manifest competences. (shrink)

This book investigates the central role of reason in Islamic intellectual life. Despite widespread characterization of Islam as a system of belief based only on revelation, John Walbridge argues that rational methods, not fundamentalism, have characterized Islamic law, philosophy and education since the medieval period. His research demonstrates that this medieval Islamic rational tradition was opposed by both modernists and fundamentalists, resulting in a general collapse of traditional Islamic intellectual life and its replacement by more modern but far shallower (...) forms of thought. However, the resources of this Islamic scholarly tradition remain an integral part of the Islamic intellectual tradition and will prove vital to its revival. The future of Islam, Walbridge argues, will be marked by a return to rationalism"--Provided by publisher. (shrink)

We present several new studies focusing on “salience effects”—the decreased tendency to attribute knowledge to someone when an unrealized possibility of error has been made salient in a given conversational context. These studies suggest a complicated picture of epistemic universalism: there may be structural universals, universal epistemic parameters that influence epistemic intuitions, but that these parameters vary in such a way that epistemic intuitions, in either their strength or propositional content, can display patterns of genuine cross-cultural diversity.

Keith DeRose’s solution to the skeptical problem is based on his indirect sensitivity account. Sensitivity is not a necessary condition for any kind of knowledge, as direct sensitivity accounts claim, but the insensitivity of our beliefs that the skeptical hypotheses are false explains why we tend to judge that we do not know them. The orthodox objection line against any kind of sensitivity account of knowledge is to present instances of insensitive beliefs that we still judge to constitute knowledge. This (...) objection line offers counter-examples against the claim of direct sensitivity accounts that sensitivity is necessary for any kind of knowledge. These examples raise an easy problem for indirect sensitivity accounts that claim that there is only a tendency to judge that insensitive beliefs do not constitute knowledge, which still applies to our beliefs that the skeptical hypotheses are false. However, a careful analysis reveals that some of our beliefs that the skeptical hypotheses are false are sensitive; nevertheless, we still judge that we do not know them. Therefore, the fact that some of our beliefs that the skeptical hypotheses are false are insensitive cannot explain why we tend to judge that we do not know them. Hence, indirect sensitivity accounts cannot fulfill their purpose of explaining our intuitions about skepticism. This is the hard problem for indirect sensitivity accounts. (shrink)

In this paper, I defend the heterogeneity problem for sensitivity accounts of knowledge against an objection that has been recently proposed by Wallbridge in Philosophia. I argue in, 479–496, 2015) that sensitivity accounts of knowledge face a heterogeneity problem when it comes to higher-level knowledge about the truth of one’s own beliefs. Beliefs in weaker higher-level propositions are insensitive, but beliefs in stronger higher-level propositions are sensitive. The resulting picture that we can know the stronger propositions without being in a (...) position to know the weaker propositions is too heterogeneous to be plausible. Wallbridge objects that there is no heterogeneity problem because beliefs in the weaker higher-level propositions are also sensitive. I argue against Wallbridge that the heterogeneity problem is not solved but only displaced. Only some beliefs in the weaker higher-level propositions are sensitive. I conclude that the heterogeneity problem is one of a family of instability problems that sensitivity accounts of knowledge face and that Wallbridge’s account raises a further problem of this kind. (shrink)

1. 1735-1738 -- 2. 1738-1743 -- 3. 1743-1754 -- 4. 1755-1765 -- 5. 1765-1775 -- 6. 1776-1786 -- 7. 1787-91.

Whiskey Lao -- Fair warning -- Randomness at large -- We the addicted -- The best possible world -- The importance of being doomed -- Moral responsibility -- The upper limit to the value of possible worlds.

A brief account of educational aims, focussing on preparation for a life of autonomous well-being.

This analysis, reverting to the question of how ethical paragons emerge from situations encountered in war, concentrates on one historical example, the case Boy-Scout Soldiers, their system of values and moral opinions. Szare Szeregi was an educational organization active from September 27, 1939 to January 17, l945 in the General Government and the provinces annexed to the Reich. Its activity was conceived as continuation of the Boy-Scout program. Under military supervision by the Home Army groups of older boys, from Szare (...) Szeregi made part of Raid Formations of the Home Army during the Warsaw Uprising and in battalions Zośka and Parasol constituted their main force. (shrink)

La présente contribution analyse les deux risques auxquels sont confrontés l’administration pénitentiaire et son personnel, les surveillants notamment, dans leur lutte contre la radicalisation : le risque de la protection insuffisante de la société face à des conversions non repérées et susceptibles d’aboutir à des actes violents de type terroriste, d’une part, et, d’autre part, le risque du signalement systématique pouvant conduire au renforcement du sentiment de discrimination chez certains détenus et, paradoxalement, constituer un terrain favorable au développement de la (...) radicalisation violente. Pour dépasser ces deux risques, il est proposé, à partir de données de terrain, une application équilibrée du principe de précaution qui devrait reposer sur une meilleure formation des personnels par la pratique, entre autres, de l’interprétation croisée. (shrink)