Rapid advances in high throughput genomic technologies and next generation sequencing are making medical genomic research more readily accessible and affordable, including the sequencing of patient and control whole genomes and exomes in order to elucidate genetic factors underlying disease. Over the next five years, the Human Heredity and Health in Africa (H3Africa) Initiative, funded by the Wellcome Trust (United Kingdom) and the National Institutes of Health (United States of America), will contribute greatly towards sequencing of numerous African samples for (...) biomedical research. (shrink)

Previous research has identified different moral judgments in liberals and conservatives. While both care about harm/fairness (‘individualizing’ foundations), conservatives emphasize in-group/authority/purity (‘binding’ foundations) more than liberals. Thus, some argue that conservatives have a more complex morality. We suggest an alternative view—that consistent with conservatism as ‘motivated social cognition’, binding foundation activation satisfies psychological needs for social structure/security/certainty. Accordingly, we found that students who were dispositionally threat-sensitive showed stronger binding foundation activation, and that conservatives are more dispositionally threat-sensitive than liberals. We (...) also found that in a heightened threat situation liberals (especially social liberals) showed increased binding foundation activation. These results support the view that the binding foundations function differently in our moral cognition than the individualizing foundations. (shrink)

Psyche and Soma is a multi-disciplinary exploration of the history of understanding of the human mind or soul and its relationship to the body, through the course of more than two thousand years. Thirteen specially commissioned chapters, each written by a recognized expert, discuss such figures as the doctors Hippocrates and Galen, the theologians St Paul, Augustine, and Aquinas, and philosophers from Plato to Leibniz.

Psyche and Soma is a multi-disciplinary exploration of the conceptions of the human soul or mind and body, through the course of more than two thousand years of Western history. Thirteen specially commissioned chapters, each written by a recogized expert, discuss figures such as the physicians Hippocrates, Galen, Stahl, and Cabanis; theologians St Paul, Augustine, and Aquinas; and philosophers from Plato and Aristotle to Descartes, Leibniz, and La Mettrie. The chapters explore in chronlogical sequence the views of these writers (...) on such questions as the soul's immortality, the control it exerts over the body, how mental disturbances arise out of bodily imbalances, and the roles of the priest and the physician in promoting spiritual and mental health. Psyche and Soma will be a key point of reference and a rich source of illumination in this central area of human inquiry. (shrink)

In this article I contrast 17th and 18th explanations of hysteria including those of Sydenham and Willis with those given by Plato and pre-modern medicine. I show that beginning in the second decade of the 17th century the locus of the disorder was transferred to the nervous system and it was no longer connected with the womb as in Hippocrates and Galen; hysteria became identified with hypochondria, and was a disease contracted by men as well as women. I discuss (...) the purely mechanical explanation of hysteria given by Robert Boyle who attributed its cause to corporeal ideas as well as overly sensitive disposition of the nervous system. I relate this the mechanical theory of the nervous system prominent in Descartes' writings on physiology. The paper closes with a discussion of the contrast between early modern explanations of hysteria and the nature of man with those of Freud in the early 20th century. (shrink)

This is a multi-disciplinary exploration of the history of understanding of the human mind or soul and its relationship to the body, through the course of more than two thousand years. Thirteen specially commissioned chapters, each written by a recognized expert, discuss such figures as the doctors Hippocrates and Galen, the theologians St Paul, Augustine, and Aquinas, and philosophers from Plato to Leibniz.

For decades scholars thought they knew Hume's position on the existence of causes and objects he was a sceptic. However, this received view has been thrown into question by the `new readings of Hume as a sceptical realist. For philosophers, students of philosophy and others interested in theories of causation and their history, The New Hume Debate is the first book to fully document the most influential contemporary readings of Hume's work. Throughout, the volume brings the debate beyond textual issues (...) in Hume to contemporary philosophical issues concerning causation and knowledge of the external world and issues in the history of philosophy, offering the reader a model for scholarly debate. This revised paperback edition includes three new chapters by Janet Broughton, Peter Kail and Peter Millican. Contributors: Kenneth A. Richman, Barry Stroud, Galen Strawson, Kenneth P. Winkler, John P. Wright, Simon Blackburn, Edward Craig, Martin Bell, Daniel Flage, Anne Jaap Jacobson, Rupert Read, Janet Broughton, Peter Millican, Peter Kail. (shrink)

The "New Hume" referred to in the title of this collection of essays is the Hume who is supposed to be a causal realist in Galen Strawson's and John Wright's senses of that term. There are, of course, other "New Humes." There is the "New Hume" who is not an inductive sceptic, the "New Hume" who is a moral realist, and the "New Hume" who is a causal realist of a very different kind, to name but a few. (...) Perhaps the book should have been called A New Hume Debate to acknowledge the many interesting and new interpretations of Hume that have very little to do with Strawson's and Wright's forms of causal realism and may even be incompatible with them. (shrink)

Jedną z centralnych kwestii dotyczących problemu wolnej woli stanowi zagadnienie moralnej odpowiedzialności. Na ogół utrzymuje się, iż ma ono najdalej idące konsekwencje dla życia społecznego oraz prawa. Jak jednak argumentuje Galen Strawson, nie można odpowiadać moralnie za własne działania. Argument przebiega następująco: dana osoba podejmuje decyzję w oparciu o swój charakter, osobowość lub inne czynniki umysłowe. Z drugiej strony, za czynniki te nie można ponosić odpowiedzialności, wydaje się bowiem oczywiste, że są one powodowane innymi czynnikami, takimi jak wychowanie czy (...) geny, za które nie jesteśmy odpowiedzialni. Jedynym wyjściem byłoby bycie causa sui, tj. bycie przyczyną samego siebie. Jednakże zgodnie z rozpowszechnioną opinią nic nie może być causa sui. W takim wypadku odpowiedzialność moralna jest niemożliwa. (shrink)

A book that pulls together the results of research by several scholars to provide a fresh look at the rich heritage of ideas that Wright contributed to the theory and practice of architecture, with special emphasis on the ordering of structuring of architectural experience. An attempt is made to convey an understanding of Wright's contributions through a direct analysis of his designs as they exist or existed in reality. The authors take a different look at Wright's work (...) in a search for clarity and understanding. (shrink)

Is experiential evidence irrelevant to acceptance or rejection of belief in the existence of a Divine Being? Charles Hartshorne answers that it is indeed irrelevant, and this answer has an initial and, for me, continuing surprising ring to it. Specifically, Hartshorne makes two distinguishable claims: the traditional allegedly a posteriori arguments, the teleological and cosmological, are in fact incompatible with empiricist methodology and are disguised ontological arguments; the conception of God as necessary being demands that belief in such a being's (...) existence or non-existence in no way depend upon empirical evidence. On the contrary, I shall argue, first, that empirical evidence for God is truly empirical and second, that there is no incompatibility between empirical evidence and necessary existence. My argument will involve an attempt to understand and clarify somewhat the very difficult concepts of ‘experience’ and ‘necessity’ as they arise in the context of religious epistemology. I wish to make clear at the outset that my aim is not to eliminate ontological arguments for God in favour of empirical arguments, for I believe that Hartshorne's work on the modal ontological argument contributes substantially to providing grounds for reasonable belief in theism. Rather, my purpose is to show that ontological and empirical patterns of theistic argumentation are neither incompatible with each other nor reducible to each other. (shrink)

-- v. 3. Truth, knowledge, and modality.

In Quod animi mores, Galen says both that there is an identity between the capacities of the soul and the mixtures of the body, and that the soul’s capacities ‘follow upon’ the bodily mixtures. The seeming tension in this text can be resolved by noting that the soul’s capacities are constituted by, and hence are nothing over and above, bodily mixtures, but bodily mixtures explain the soul’s capacities and not the other way around. Galen’s proposal represents a distinctive (...) position in the Ancient debate on the relationship between soul and body. (shrink)

It can be said that both Plato's tripartite soul and Hippocrates' theory of temperament were influential in Galen's perception of ethics. In this respect, Galen, who presents a kind of composition of the effective philosophical and medical traditions of his day, is outside the tradition with his understanding of physicalist psychology. Considering the capacities of the soul as depending on the temperament of the body, Galen generally displays a deterministic attitude towards ethics, that is, the development of (...) the soul. This is because the natural and physical structure is difficult to change. On the other hand, Galen, whom we can call both a physician and a "philosophical therapist", argues that character traits (ethos) can be changed "to the extent that nature allows" through education and habituation at an early age. This article will try to determine and evaluate the possibility Galen ascribes to ethical change and development in humans in the context of character traits. (shrink)

This paper focuses on Galen’s views about the formal cause against the wider background of his account of causation. In his works on the pulse, Galen provides an in-depth discussion of issues such as the theory of causes and the problem of definition. While Galen is inclined to incorporate Peripatetic doctrines and vocabulary, he neglects Aristotle’s formal cause both in his account of causes and in that of definition. Further parallels outside the corpus on the pulse confirm (...) Galen’s reserved attitude towards the (Peripatetic) formal cause. In his work That the Faculties of the Soul Follow the Mixtures of the Body, however, Galen refers favourably to the Peripatetic theory of hylomorphic form. More precisely, Galen equates the Peripatetic en-mattered form with the mixture of homoeomerous bodies (the ratio or proportion of the elementary qualities in them). Here I will attempt to provide an explanation of Galen’s mixed attitude towards the formal cause and I will argue that his general position is consistent after all. In addition to this, I will try to set Galen’s position against the background of the Peripatetic debates on the status of form. (shrink)

_Zettel, _ an en face bilingual edition, collects fragments from Wittgenstein's work between 1929 and 1948 on issues of the mind, mathematics, and language.

This article explores Galen's analysis of and response to the Rationalist and Empiricist medical sects. It argues that his interest in their debate concerning the epistemology of medicine and anatomy was key to his advancement of an experimental methodology.

Galen is well known as a critic of Stoicism, mainly for his massive attack on Stoic (or at least, Chrysippean) psychology in "On the Doctrines of Hippocrates and Plato" (PHP) 2-5. Galen attacks both Chrysippus' location of the ruling part of the psyche in the heart and his unified or monistic picture of human psychology. However, if we consider Galen's thought more broadly, this has a good deal in common with Stoicism, including a (largely) physicalist conception of (...) psychology and a strongly teleological view of natural entities, shared features which are acknowledged in several treatises outside "PHP." Why, then, is Galen such a remorseless and negative critic of Stoicism in "PHP"? Various factors are relevant, including the shaping influence on Galen of the Platonic-Aristotelian (part-based) psychological framework. But, it is suggested here, an important underlying factor is the contrast between two ways of thinking about the part-whole relationship, a 'composition' and a 'structure' approach or an atomistic and holistic approach. This contrast is most evident and explicit in one section of "PHP" 5, where Galen, criticising Chrysippus' holistic psychology, denies that the Stoic thinker is entitled to use the concept of part at all. But the contrast is also seen as pervading Galen's response to Stoic thought more generally, in "PHP" and elsewhere, in ways that inform his explicit disagreements with Stoic theory. Stoicism is presented here as having a consistently 'structure' (or holistic) approach. Galen's approach is seen as more mixed, sometimes sharing, or aspiring towards, a holistic picture, and yet sometimes (especially in "PHP" 5), adopting a strongly 'composition' or atomistic standpoint. This (partial) contrast in conceptual frameworks is presented as offering a new perspective on Galen's critique of Stoic psychology in "PHP" and on his relationship to Stoic thought more generally. (shrink)

In On my own opinions, Galen claims to agree with Aristotle that the soul is the form of the body. But should we take this statement at face value? After all, Galen says that the substance of the soul is a bodily mixture, and that the soul is the form of the body in the sense that it is the principle of mixing of the elementary qualities (i.e., hot, cold, wet, and dry). As is well known, Aristotle explicitly (...) rejects this sort of materialist account of the soul. In De Anima, he tells us that the soul cannot be a harmonia of bodily elements, understood either as the proportion according to which the elements are mixed, or as the mixtures themselves (I.4, 407b32-408a2). In this chapter, I argue that Galen rejects a substantive version of hylomorphism, in favor of a view according to which the soul’s substance is nothing other than a bodily mixture. Galen’s position contains a veiled objection to some central Aristotelian views and reveals a general suspicion regarding the Aristotelian notion of form as a genuine metaphysical and explanatory category. (shrink)

Crispin Wright in his 1982 paper argues for strict finitism, a constructive standpoint that is more restrictive than intuitionism. In its appendix, he proposes models of strict finitistic arithmetic. They are tree-like structures, formed in his strict finitistic metatheory, of equations between numerals on which concrete arithmetical sentences are evaluated. As a first step towards classical formalisation of strict finitism, we propose their counterparts in the classical metatheory with one additional assumption, and then extract the propositional part of ‘strict (...) finitistic logic’ from it and investigate. We will provide a sound and complete pair of a Kripke-style semantics and a sequent calculus, and compare with other logics. The logic lacks the law of excluded middle and Modus Ponens and is weaker than classical logic, but stronger than any proper intermediate logics in terms of theoremhood. In fact, all the other well-known classical theorems are found to be theorems. Finally, we will make an observation that models of this semantics can be seen as nodes of an intuitionistic model. (shrink)

This essay examines several important issues regarding Galen's depiction of the physiology of the arteries. In the process some of Galen's supporting doctrines on the blood and pulse will also be discussed in the context of a coherent scientific explanation. It will be the contention of this essay that though Galen may often have a polemical goal in mind, he correctly identifies the important and complex role of the arteries in human biological systems.

Here, Bob Hale and Crispin Wright assemble the key writings that lead to their distinctive neo-Fregean approach to the philosophy of mathematics. In addition to fourteen previously published papers, the volume features a new paper on the Julius Caesar problem; a substantial new introduction mapping out the program and the contributions made to it by the various papers; a section explaining which issues most require further attention; and bibliographies of references and further useful sources. It will be recognized as (...) the most powerful presentation yet of a neo-Fregean program. (shrink)

The author makes the case for sortition from a Marxist perspective, explaining how sortition could become part of an anticapitalist political strategy.

ABSTRACT Four philosophical concerns about higher-order logic in general and the specific demands placed on it by the neo-logicist project are distinguished. The paper critically reviews recent responses to these concerns by, respectively, the late Bob Hale, Richard Kimberly Heck, and myself. It is argued that these score some successes. The main aim of the paper, however, is to argue that the most serious objection to the applications of higher-order logic required by the neo-logicist project has not been properly understood. (...) The paper concludes by outlining a strategy, prefigured in recent work of Øystein Linnebo, for meeting this objection. (shrink)

The author examines the question of Galen's affinity with astrology, in view of Galen's extended astrological discussion in the De diebus decretoriis . The critical passages from Galen are examined, and shown to be superficial in understanding. The author performs a lexical sounding of Galen's corpus, using key terms with astrological valences drawn from the Critical Days, and assesses their absence in Galen's other works. He compares Galen's astrology with the astrology of Ptolemy's Tetrabiblos, (...) and evaluates their respective strategies of scientific reasoning. Three types of inference are introduced and applied to Galen's astrology. Finally, he concludes that the empirical side of Galen's science does not depend upon astrological methods or concepts, but that these were introduced for their rhetorical effect in presenting his new medical methodology. It is suggested that continued attention to Galen's astrology has obscured the truly important empirical scientific method that Galen developed. (shrink)

As a result of this case study, additional questions arise. These can be cast into at least three groups. The first concerns the development of critical empiricism in the ancient world: a topic of much interest in our own century, expecially with regard to the work of the logical empiricists. Many of the same arguments are present in the ancient world and were hotly debated from the Hippocratic writers through and beyond Galen. Some of the ways in which (...) class='Hi'>Galen reacts to Hippocratic and Aristotelian influences may, in part, be explained by Galen's own posture as a so-called Dogmatist. Both the Empirics and the Methodists offered alternative viewpoints on the place, role, and limits of observation in biomedical research. Though I have written on this relationship in the Hippocratic writers and Aristotle,44 it remains to be discussed in detailed fashion just how critical empiricism acted in Galen's evaluation of biomedical problems (aporiai). Contrasts between Galen and his predecessors might further clarify this issue both as a historical question and as it affects the construction of biological theory.The second area explores the question of how one develops comprehensive theories. In this respect Galen follows Aristotle's methodology rather closely. Both look at what theories are available to them and then systematically review the problems raised, at the same time refuting what they find inadequate. This is an effective strategy, for it permits utilizing the best features of earlier work to fashion a new whole. Indeed, Galen himself seems to attribute his use of such a methodology to his “ecletic” medical and philosophical training. Both Aristotle and Galen endeavor to employ techniques of theory integration. That is, they use aspects of theories they have already espoused to deal with new problems. This suggests the emergence of formal, logical coherence as an element in theory evaluation. The obvious drawback is that it can cause mistakes in one area to be repeated and ingrained in other areas. Such errors, because they are at the very core of an explanatory framework, may take centuries to correct. Future studies may shed light on how theory integration acts both in a positive and in a negative way.Finally, this case study offers a glimpse of how science progresses. Even though the advances in medical technology were comparatively minor, there is a great deal more sophistication in the conception theoreis of Aristotle and Galen than was present in the Hippocratic writers. Some of this (in Galen's case) had to do with increased anatomic and physiological knowledge, but most, I believe, is due to the evolution of scientific knowledge. If further work were done specifically on this question, it might document more completely how scientific knowledge on a specific topic evolves. The mode of advancement is primarily through gradual refinement of the types of questions being asked by these ancient authors, and the ramifications of their answers.Ancient theories of conception offer a fine case study in the history and philosophy of how a theory begins the develops. I have tried to suggest some interrelationships among the more important theories, as they focused upon Aristotle's own conception theory. There has been renewed interest in such cases in recent years. It is my hope that future specialized studies will increase our knowledge of method and practice in these important case studies and thereby augment our understanding of the genesis and application of biological theories. (shrink)

Name der Zeitschrift: Apeiron Jahrgang: 50 Heft: 4 Seiten: 449-481.

This essay situates the French Jesuit missionary Joseph-François Lafitau's (1681–1746) ‘discovery’ of Canadian ginseng within its social, commercial and religious contexts, and illustrates how the missionary's upbringing and education in France shaped the way he perceived nature in the New World. It elucidates the manner in which Lafitau ‘Galenized’ Canadian flora, fauna and peoples. It explores the role of Lafitau's dual enculturation in both a mercantile household and later the Society of Jesus in his application of Galenic categories to Canadian (...) nature. The essay then examines the tensions between localism and universalism in Galenic medicine in the eighteenth century. It links these dichotomies to Lafitau's Galenization of Canadian ginseng. Finally, it suggests that since the Jesuits were prohibited from trading goods they had purchased, they sold medicinal plants they had cultivated themselves, which played a central role in financing the Society's missions in a manner they believed to be morally acceptable. (shrink)

Crispin Wright joins the ranks of those who have sought to refute mechanist theories of mind by invoking Gödel's Incompleteness Theorems. His predecessors include Gödel himself, J. R. Lucas and, most recently, Roger Penrose. The aim of this essay is to show that, like his predecessors, Wright, too, fails to make his case, and that, indeed, he fails to do so even when judged by standards of success which he himself lays down.

Fred Dretske notoriously claimed that knowledge closure sometimes fails. Crispin Wright agrees that warrant does not transmit in the relevant cases, but only because the agent must already be warranted in believing the conclusion in order to acquire her warrant for the premise. So the agent ends up being warranted in believing, and so knowing, the conclusion in those cases too: closure is preserved. Wright's argument requires that the conclusion's having to be warranted beforehand explains transmission failure. I (...) argue that it doesn't, and that the correct explanation does not imply that the agent will end up warranted in believing the conclusion when transmission fails. Those who agree that transmission does fail in those cases, therefore, might as well follow Dretske in denying knowledge closure too. (shrink)

All Galen's surviving shorter works on psychology and ethics - including the recently discovered Avoiding Distress, and the neglected Character Traits, extant only in Arabic - are here presented in one volume in a new English translation, with substantial introductions and notes and extensive glossaries. Original and penetrating analyses are provided of the psychological and philosophical thought, both of the above and of two absolutely central works of Galenic philosophy, Affections and Errors and The Capacities of the Soul, by (...) some of the foremost experts in the field. Each treatise has also been subjected to fresh textual study, taking account of the latest scholarly developments, and is presented with accompanying textual discussions, adding greatly to the value and accuracy of the work without detracting from its accessibility to a wider readership. The volume thus makes a major contribution to the understanding of the ancient world's most prominent doctor-philosopher in his intellectual context. (shrink)

Sewall Wright and Gustave Malécot developed important theories of isolation by distance. Wright’s theory was statistical and Malécot’s probabilistic. Because of this mathematical difference, they were not clear about the relationship between their theories. In this paper, I make two points to clarify this relationship. First, I argue that Wright’s theory concerns what I call ecological isolation by distance , whereas Malécot’s concerns what I call genetic isolation by distance . Second, I suggest that if Wright’s (...) theory is interpreted appropriately, a previously unnoticed connection between the two theories emerges. †To contact the author, please write to: Yoichi Ishida, Department of History and Philosophy of Science, University of Pittsburgh, 1017 Cathedral of Learning, Pittsburgh, PA 15260; e‐mail: [email protected]. (shrink)