Rapid advances in high throughput genomic technologies and next generation sequencing are making medical genomic research more readily accessible and affordable, including the sequencing of patient and control whole genomes and exomes in order to elucidate genetic factors underlying disease. Over the next five years, the Human Heredity and Health in Africa (H3Africa) Initiative, funded by the Wellcome Trust (United Kingdom) and the National Institutes of Health (United States of America), will contribute greatly towards sequencing of numerous African samples for (...) biomedical research. (shrink)

Previous research has identified different moral judgments in liberals and conservatives. While both care about harm/fairness (‘individualizing’ foundations), conservatives emphasize in-group/authority/purity (‘binding’ foundations) more than liberals. Thus, some argue that conservatives have a more complex morality. We suggest an alternative view—that consistent with conservatism as ‘motivated social cognition’, binding foundation activation satisfies psychological needs for social structure/security/certainty. Accordingly, we found that students who were dispositionally threat-sensitive showed stronger binding foundation activation, and that conservatives are more dispositionally threat-sensitive than liberals. We (...) also found that in a heightened threat situation liberals (especially social liberals) showed increased binding foundation activation. These results support the view that the binding foundations function differently in our moral cognition than the individualizing foundations. (shrink)

Psyche and Soma is a multi-disciplinary exploration of the conceptions of the human soul or mind and body, through the course of more than two thousand years of Western history. Thirteen specially commissioned chapters, each written by a recogized expert, discuss figures such as the physicians Hippocrates, Galen, Stahl, and Cabanis; theologians St Paul, Augustine, and Aquinas; and philosophers from Plato and Aristotle to Descartes, Leibniz, and La Mettrie. The chapters explore in chronlogical sequence the views of these writers (...) on such questions as the soul's immortality, the control it exerts over the body, how mental disturbances arise out of bodily imbalances, and the roles of the priest and the physician in promoting spiritual and mental health. Psyche and Soma will be a key point of reference and a rich source of illumination in this central area of human inquiry. (shrink)

Psyche and Soma is a multi-disciplinary exploration of the history of understanding of the human mind or soul and its relationship to the body, through the course of more than two thousand years. Thirteen specially commissioned chapters, each written by a recognized expert, discuss such figures as the doctors Hippocrates and Galen, the theologians St Paul, Augustine, and Aquinas, and philosophers from Plato to Leibniz.

In this article I contrast 17th and 18th explanations of hysteria including those of Sydenham and Willis with those given by Plato and pre-modern medicine. I show that beginning in the second decade of the 17th century the locus of the disorder was transferred to the nervous system and it was no longer connected with the womb as in Hippocrates and Galen; hysteria became identified with hypochondria, and was a disease contracted by men as well as women. I discuss (...) the purely mechanical explanation of hysteria given by Robert Boyle who attributed its cause to corporeal ideas as well as overly sensitive disposition of the nervous system. I relate this the mechanical theory of the nervous system prominent in Descartes' writings on physiology. The paper closes with a discussion of the contrast between early modern explanations of hysteria and the nature of man with those of Freud in the early 20th century. (shrink)

This is a multi-disciplinary exploration of the history of understanding of the human mind or soul and its relationship to the body, through the course of more than two thousand years. Thirteen specially commissioned chapters, each written by a recognized expert, discuss such figures as the doctors Hippocrates and Galen, the theologians St Paul, Augustine, and Aquinas, and philosophers from Plato to Leibniz.

Here, Bob Hale and Crispin Wright assemble the key writings that lead to their distinctive neo-Fregean approach to the philosophy of mathematics. In addition to fourteen previously published papers, the volume features a new paper on the Julius Caesar problem; a substantial new introduction mapping out the program and the contributions made to it by the various papers; a section explaining which issues most require further attention; and bibliographies of references and further useful sources. It will be recognized as (...) the most powerful presentation yet of a neo-Fregean program. (shrink)

What is the self? Does it exist? If it does exist, what is it like? It's not clear that we even know what we're asking about when we ask these large, metaphysical questions. The idea of the self comes very naturally to us, and it seems rather important, but it's also extremely puzzling. As for the word "self"--it's been taken in so many different ways that it seems that you can mean more or less what you like by it and (...) come up with almost any answer. Galen Strawson proposes to approach the (seeming) problem of the self by starting from the thing that makes it seem there is a problem in the first place: our experience of the self, our experience of having or being a self, a hidden, inner mental presence or locus of consciousness. He argues that we should consider the phenomenology (experience) of the self before we attempt its metaphysics (its existence and nature). And when we have considered what it's like for human beings (assuming we can generalize about ourselves), we need to consider what it might be like for other possible creatures: what's the very least that might count as experience of oneself as a self? This, he proposes, will give us a good idea of what we ought to be looking for when we go on to ask whether there is such a thing-an idea worth following wherever it leads. It leads Strawson to conclude that selves, inner subjects of experience, do indeed exist. But they bear little resemblance to traditional conceptions of the self. (shrink)

This lucid book is the first to be wholly dedicated to Hume's theory of personal identity, and presents a bold new interpretation which bears directly on ...

‘Free will’ is the conventional name of a topic that is best discussed without reference to the will. It is a topic in metaphysics and ethics as much as in the philosophy of mind. Its central questions are ‘What is it to act (or choose) freely?’, and ‘What is it to be morally responsible for one’s actions (or choices)?’ These two questions are closely connected, for it seems clear that freedom of action is a necessary condition of moral responsibility, even (...) if it is not sufficient. (shrink)

This paper presents the data gathering of Matthew Fontine Maury at the U.S. Naval Observatory as pushing an epistemic boundary outside traditional laboratory walls. Maury's use and control of civilian navigators explicates the development of an astronomic epistemology deeply embedded in nineteenth century American society. In conclusion, following the movement of epistemic boundaries is offered as a guide to crucial moments in the development of a multifaceted modernity.

In this article I introduce a simple classroom exercise intended to help students better understand Robert Nozick’s famous Wilt Chamberlain thought experiment. I outline the setup and rules of the Basic Version of the Game and explain its primary pedagogical benefits. I then offer several more sophisticated versions of the Game which can help to illustrate the difference between Nozick’s libertarianism and luck egalitarianism.

One of the key achievements of critical realism has been to expose the modernist myth of universal reason, which holds that authentic knowledge claims must be objectively ‘pure’, uncontaminated by the subjectivity of local place, specific time and particular culture. Wright aims to address the lack of any substantial and sustained engagement between critical realism and theological critical realism with particular regard to: (a) the distinctive ontological claims of Christianity; (b) their epistemic warrant and intellectual legitimacy; and (c) scrutiny (...) of the primary source of the ontological claims of Christianity, namely the historical figure of Jesus of Nazareth. As such, it functions as a prolegomena to a much needed wider debate, guided by the under-labouring services of critical realism, between Christianity and various other religious and secular worldviews. This important new text will help stimulate a debate that has yet to get out of first gear. This book will appeal to academics, graduate and post-graduate students especially, but also Christian clergy, ministers and informed laity, and members of the general public concerned with the nature of religion and its place in contemporary society. (shrink)

Short version of 'Real materialism', given at Tucson III Conference, 1998. (1) physicalism is true (2) the qualitative character of experience is real, as most naively understood ... so (3) the qualitative character of experience (considered specifically as such) is wholly physical. ‘How can consciousness possibly be physical, given what we know about the physical?’ To ask this question is already to have gone wrong. We have no good reason (as Priestley and Russell and others observe) to think that we (...) know anything about the physical that gives us any reason to find any problem in the idea that consciousness is wholly physical. (shrink)

I Two Traditions. Scientific inquiry, seen in a very broad perspective, may be said to present two main aspects. One is the ascertaining and discovery of ...

Reply to commentators on the paper 'Realistic monism: why physicalism entails panpsychism'.

I argue against two popular claims. The first is a descriptive, empirical thesis about the nature of ordinary human experience: ‘each of us constructs and lives a “narrative” . . . this narrative is us, our identities’ (Oliver Sacks); ‘self is a perpetually rewritten story . . . in the end, we become the autobiographical narratives by which we “tell about” our lives’ (Jerry Bruner); ‘we are all virtuoso novelists. . . . We try to make all of our material (...) cohere into a single good story. And that story is our autobiography. The chief fictional char- acter . . . of that autobiography is one’s self’ (Dan Dennett). The second is a normative, ethical claim: we ought to live our lives narratively, or as a story; a ‘basic condition of making sense of ourselves is that we grasp our lives in a narrative’ and have an understanding of our lives ‘as an unfolding story’ (Charles Taylor). A person ‘creates his identity [only] by forming an autobiographical narrative – a story of his life’, and must be in possession of a full and ‘explicit narrative [of his life] to develop fully as a person’ (Marya Schechtman). (shrink)

This paper is a reply to George Boolos's three papers (Boolos (1987a, 1987b, 1990a)) concerned with the status of Hume's Principle. Five independent worries of Boolos concerning the status of Hume's Principle as an analytic truth are identified and discussed. Firstly, the ontogical concern about the commitments of Hume's Principle. Secondly, whether Hume's Principle is in fact consistent and whether the commitment to the universal number by adopting Hume's Principle might be problematic. Also the so-called `surplus content' worry is discussed, (...) which points out that the conceptual resources to grasp Hume's Principle vastly outstrip the conceptual resources employed in arithmetical reasoning. And lastly whether Hume's Principle is in bad company with other unsuccessful implicit definitions. In the last section, an account towards our entitlement to Hume&'s Principle is sketched. (shrink)

Greek text, english translation and commentary on the surviving fragments of Empedocles (fragments as known in 1981, does not include more recent finds).

Many students struggle to enter moral debates in a productive way because they automatically think of moral claims as ‘just opinions’ and not something one could productively argue about. Underlying this response are various versions of a muddled distinction between ‘facts’ and ‘opinions.’ This paper outlines a way to help students overcome their use of this distinction, thereby clearing an obstacle to true moral debate. It explains why the fact-opinion distinction should simply be scrapped, rather than merely sharpened. It then (...) proposes a different distinction well suited to replace it. Finally, it outlines an activity which can be used to teach the new distinction, as well as a number of benefits to attempting the whole replacement process. (shrink)

Spinoza reasons about impossibilities on a regular basis. But he also says they're unthinkable and that reasoning is a mental process. How can he do this? The paper defends a linguistic account of counterpossible inferences in Spinoza's geometrical method.

Clarke attacks Spinoza's monism on the grounds that it cannot explain how a multiplicity of things follows from one substance, God. This article argues that Clarke assumes that Spinoza's God is countable. It then sketches a way in which multiplicity can follow from God's uncountable nature.

Marshall and colleagues (2024) contribute to the literature on autonomy and decision-making capacity by focusing on the case of individuals with opioid use disorder who refuse to remain in the hosp...

One worrying aspect of contemporary Western Society is the increasing prevalence of instances of ‘Science Denial’ in popular culture. Examples include both cases where well-attested scientific hypotheses are rejected and conversely, where scientifically discredited ideas are stubbornly retained. The paper raises the question whether the kind of argument for an anti-realist conception of empirical scientific theory considered in my contribution to the inaugural issue of this journal could in principle provide intellectual succour for these trends. The discussion proceeds through an (...) examination of the role of ‘takings for granted’ in all reflective enquiry to the conclusion that a trusting acceptance of the general credibility of informants is a precondition for the exercise of individual epistemic responsibility, and that in that context an acceptance of at least the empirical adequacy, if not the truth, realistically understood, of the teachings of scientists in general is rationally non-optional. (shrink)

Real Materialism is a collection of highly original essays on a set of related topics in philosophy of mind and metaphysics: consciousness and the mind-body problem; our knowledge of the world; the nature of the self or subject; free will and moral responsibility; the nature of thought and intentionality; causation and David Hume.

Malebranche argues that we lack a clear idea of the mind because we cannot, even in principle, derive all the possible modes of mind solely from the idea of thought. But we can, in principle, derive all the possible modes of body from the idea of extension. Therefore, there is epistemic asymmetry between our ideas of mind and body. I offer a defense of Descartes whereby he can assert that we have a clear idea of mind despite this asymmetry. I (...) argue that he can do this by distinguishing the simplicity of mind from the divisibility of body. (shrink)

Contents: Introduction, Bibliography On the Sects for Beginners An Outline of Empiricism On Medical Experience Index of the Persons Mentioned in the Texts Index of the Subjects Mentioned in the Texts.

What does it mean to listen to someone respectfully, that is, insofar as they are due recognition respect? This paper addresses that question and gives the following answer: it is to listen in such a way that you are open to being surprised. A specific interpretation of this openness to surprise is then defended.

The concept of determinism proves to be a persistent stumbling block to student comprehension of issues surrounding free will. Students tend to commit two main errors. First, they often confuse determinism with the related but importantly different idea of fatalism. Second, students often do not adequately understand that mental states, such as desires or beliefs, can function as deterministic causes. This paper outlines a straightforward in-class exercise modeled after John Horton Conway’s “Game of Life” computer simulation. The exercise aims to (...) address the two main obstacles to understanding determinism and, as a result, improve student understanding of free will topics. (shrink)

ABSTRACTMost of Spinoza’s arguments for God’s existence do not rely on any special feature of God, but instead on merely general features of substance. This raises the following worry: those arguments prove the existence of non-divine substances just as much as they prove God’s existence, and yet there is not enough room in Spinoza’s system for all these substances. I argue that Spinoza attempts to solve this problem by using a principle of plenitude to rule out the existence of other (...) substances and that the principle cannot be derived from the PSR, as many claim.Abbreviation: PSR: Principle of Sufficient Reason. (shrink)

This paper considers Hume’s account of personal identity in his Treatise of Human Nature. It argues for three connected claims. Hume does not endorse a “bundle theory” of mind, according to which the mind or self is simply a “bundle” of perceptions; he thinks that “the essence of the mind [is] unknown to us.” Hume does not deny the existence of subjects of experience; he does not endorse a “no self” or “no ownership” view. Hume does not claim that the (...) subject of experience is not encountered in experience. The paper also examines Hume’s phenomenological account of self-experience—of what he comes across when he engages in mental self-examination by “entering intimately into what I call myself”—and his psychological account of how we come to believe in the existence of a persisting self as a result of the mind’s “sliding easily” along certain series of perceptions. (shrink)

ABSTRACTWe seem to have a direct experience of our freedom when we act. Many philosophers take this feeling of freedom as evidence that we possess libertarian free will. Spinoza denies that we have free will of any sort, although he admits that we nonetheless feel free. Commentators often attribute to him what I call the ‘Negative Account’ of the feeling: it results from the fact that we are conscious of our actions but ignorant of their causes. I argue that the (...) Negative Account is flawed. The feeling of freedom also depends on a vacillation of the mind. When the mind forms too many incompatible associations, it vacillates between them. When we act, the mind vacillates back and forth between the kinds of actions that we associate with our present mental state. We then mistake this subjective vacillation for an objective feature of ourselves—namely, the power to do otherwise. (shrink)

Method of Medicine, a systematic and comprehensive account of the principles of treating injury and disease and one of Galen's greatest and most influential works.

This book addresses a very real gap in existing introductory texts that define, explore, and apply key theoretical concepts within the field of film studies.' Alison L. McKee, Assistant Professor, Department of Television-Radio-Film-Theatre, San Jose State University, USA 'This is the book that film students have long been waiting for: a clear, well-written and accessible introduction to film theory. Lucid theoretical exposition and case study film analysis offer readers the most intelligible summary of theory that I have yet encountered.' Paul (...) Sutton, Head of Media, Culture and Language, Roehampton University Film theory has a reputation for being difficult. It is challenging, it takes time and it can frequently leave students feeling inadequate and frustrated. Furthermore, theory can often seem intimidating and oldfashioned and therefore it can be difficult to appreciate its modern-day relevance. Understanding Film Theory aims to disassociate theory from these negative connotations and bring a fresh, modern and accessible approach to the discipline. Each of the fifteen chapters provides an insight into the main areas of debate by introducing key ideas and thinkers. Taking the application of theory as its central theme, the book incorporates a number of exciting and innovative features: 'Reflect and Respond' sections encourage readers to engage critically with theoretical concepts, while seminal texts are concisely summarized without oversimplifying key points. Throughout the book the authors illustrate why theory is important and demonstrate how it can be applied in a meaningful way, with relevant case studies drawn from both classic and contemporary cinema including: Once Upon a Time in the West (1968), Run Lola Run (1998), Moulin Rouge! (2001), Rabbit-Proof Fence (2002), Old Boy (2003), Brokeback Mountain (2005), Mamma Mia! (2008) and Avatar (2009). Additional case studies address key genres ('swashbucklers' and the film musical), film movements (Dogme 95), individual actors (Christian Bale, Judi Dench and Amitabh Bachchan) and directors (Alfred Hitchcock and Guillermo del Toro). Understanding Film Theory is an accessible and comprehensive introduction to film theory. It is the ideal entry point for any student studying film, using clear definitions and explaining complex ideas succinctly. Christine Etherington-Wright is a Senior Lecturer in Film Studies at University of Portsmouth (UK) where she teaches a course on Film Theory. She is the author of Gender, Professions, Discourse (Palgrave, 2008). Ruth Doughty is a Senior Lecturer in Film Studies at University of Portsmouth (UK). She is one of the co-founding editors of the journal Transnational Cinemas and co-edited Sound and Music in Film and Visual Media (2008). (shrink)

Introduction -- A default position -- Experience -- The character of experience -- Understanding-experience -- A note about dispositional mental states -- Purely experiential content -- An account of four seconds of thought -- Questions -- The mental and the nonmental -- The mental and the publicly observable -- The mental and the behavioral -- Neobehaviorism and reductionism -- Naturalism in the philosophy of mind -- Conclusion: The three questions -- Agnostic materialism, part 1 -- Monism -- The linguistic argument (...) -- Materialism and monism -- A comment on reduction -- The impossibility of an objective phenomenology -- Asymmetry and reduction -- Equal-status monism -- Panpsychism -- The inescapability of metaphysics -- Agnostic materialism, part 2 -- Ignorance -- Sensory spaces -- Experience, explanation, and theoretical integration -- The hard part of the mind-body problem -- Neutral monism and agnostic monism -- A comment on eliminativism, instrumentalism, and so on -- Mentalism, idealism, and immaterialism -- Mentalism -- Strict or pure process idealism -- Active-principle idealism -- Stuff idealism -- Immaterialism -- The positions restated -- The dualist options -- Frege's thesis -- Objections to pure process idealism -- The problem of mental dispositions -- Mental -- Shared abilities -- The sorting ability -- The definition of mental being -- Mental phenomena -- The view that all mental phenomena are experiential phenomena -- Natural intentionality -- E/c intentionality -- The experienceless -- Intentionality and abstract and nonexistent objects -- Experience, purely experiential content, and n/c intentionality -- Concepts in nature -- Intentionality and experience -- Summary with problem -- Pain and pain -- The neo-behaviorist view -- A linguistic argument for the necessary connection between pain and behavior -- A challenge -- The Sirians -- N.N. Novel -- An objection to the Sirians -- The Betelgeuzians -- The point of the Sirians -- Functionalism, naturalism, and realism about pain -- Unpleasantness and qualitative character -- The weather watchers -- The rooting story -- What is it like to be a weather watcher? -- The aptitudes of mental states -- The argument from the conditions for possessing the concept of space -- The argument from the conditions for language ability -- The argument from the nature of desire -- Desire and affect -- The argument from the phenomenology of desire -- Behavior -- A hopeless definition -- Difficulties -- Other-observability -- Neo-behaviorism -- The concept of mind. (shrink)