Aging is an elusive property of life, and many important questions about aging depend on its definition. This article proposes to draw a definition from the scientific literature on aging. First, a broad review reveals five features commonly used to define aging: structural damage, functional decline, depletion, typical phenotypic changes or their cause, and increasing probability of death. Anything that can be called ‘aging’ must present one of these features. Then, although many conditions are not consensual instances of aging, aging (...) is consensually described as a process of loss characterized by a rate and resulting from the counteraction of protective mechanisms against mechanisms that limit lifespan. Beyond such an abstract definition, no one has yet succeeded in defining aging by a specific mechanism of aging because of an explanatory gap between such a mechanism and lifespan, a consensual explanandum of a theory of aging. By contrast, a sound theoretical definition can be obtained by revisiting the evolutionary theory of aging. Based on this theory, aging evolves thanks to the impossibility that natural selection eliminates late traits that are neutral mainly due to decreasing selective pressure. Yet, the results of physiological research suggest that this theory should be revised to also account for the small number of different aging pathways and for the existence of mechanisms counteracting these pathways, that must, on the contrary, have been selected. A synthetic, but temporary definition of aging can finally be proposed. (shrink)

In this paper we argue that questions about which mathematical ideas mathematicians are exposed to and choose to pay attention to are epistemologically relevant and entangled with power dynamics and social justice concerns. There is a considerable body of literature that discusses the dissemination and uptake of ideas as social justice issues. We argue that these insights are also relevant for the epistemology of mathematics. We make this visible by a journalistic exploration of relevant cases and embed our insights into (...) the larger question how mathematical ideas are taken up in mathematical practices. We argue that epistemologies of mathematics ought to account for questions of exposure to and choice of attention to mathematical ideas, and remark on the political relevance of such epistemologies. (shrink)

In _Life-Destroying Diagrams_, Eugenie Brinkema brings the insights of her radical formalism to bear on supremely risky terrain: the ethical extremes of horror and love. Through close readings of works of film, literature, and philosophy, she explores how diagrams, grids, charts, lists, abecedaria, toroids, tempos, patterns, colors, negative space, lengths, increments, and thresholds attest to formal logics of torture and cruelty, violence and finitude, friendship and eros, debt and care. Beginning with a wholesale rethinking of the affect of horror, orienting (...) it away from entrenched models of feeling toward impersonal schemes and structures, Brinkema moves outward to consider the relation between objects and affects, humiliation and metaphysics, genre and the general, bodily destruction and aesthetic generation, geometry and scenography, hatred and value, love and measurement, and, ultimately, the tensions, hazards, and speculative promise of formalism itself. Replete with etymological meditations, performative typography, and lyrical digressions, _Life-Destroying Diagrams_ is at once a model of reading without guarantee and a series of generative experiments in the writing of aesthetic theory. (shrink)

To those who have observed it for a long time, the People's Republic of China today has the appearance of a convalescent who has made his way back from a long illness and is slowly relearning to use his vital organs. And this is the consequence of the decisive and remarkable measures taken after the death of Mao Tse-tung and the subsequent elimination of his abusive widow, Chiang Ch'ing, by survivors of the great cultural revolution, now in the upper circles (...) of the Chinese Communist party. Explanations were provided in the “Resolution on the History of the Chinese Communist Party” adopted June 27, 1981, at the Sixth Plenary Session of the Central Committee of the Eleventh Party Congress. But the real turning point dates from 1978, in the historic third session of this same Eleventh Congress when the opposition to Mao's chosen successor, Hua Guo-feng, called upon participants to “liberate their minds and to seek truth in the facts”. A new People's China had begun to take shape, and although it is not yet possible to pass judgement on its future prospects, visitors who travel there today can only bear witness to the return of this immense population to existential reality, while little by little the “barracks socialism” of the ultra-leftists is dying out. (shrink)

From student protests over the teaching of canonical texts such as Plato's Republic to the use of images of classical Greek statues in white supremacist propaganda, the world of the ancient Greeks is deeply implicated in a heated contemporary debate about identity and diversity. In Plato's Caves, Rebecca LeMoine defends the bold thesis that Plato was a friend of cultural diversity, contrary to many contemporary perceptions. Through close readings of four Platonic dialogues--Republic, Menexenus, Laws, and Phaedrus--LeMoine shows that, (...) across Plato's dialogues, foreigners play a role similar to that of Socrates: liberating citizens from intellectual bondage. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 11.1 (2004) 87-94 [Access article in PDF] Talk and the Nature of Delusions:Defending Sociocultural Perspectives on Mental Illness Eugenie Georgaca Keywords discourse, social constructionism, delusions, psychosis, mental illness, context It is very pleasing to see writers from philosophy, psychiatry and psychology, the three disciplines represented by this journal, debating the issue of delusions. The majority of the papers in this volume set out to determine (...) the underlying mechanisms responsible for delusions. As such, they offer themselves as discussions of the etiological factors of the formation and maintenance of delusions. My paper analyzes the interactional presentation and negotiation of statements that would be considered as delusional. This led some commentators (Ghaemi 2004; Sass 2004) to argue that the analysis of talk about delusions is useful, but cannot be extended to claims about the nature of delusions. In the following section, I discuss the ways in which analyzing interactions can be useful in clinical research and practice. Subsequently, I identify and critically discuss the assumptions about the nature of delusions that underlie these criticisms and the majority of the papers in this volume. The Usefulness of the Study of Interaction My paper can be seen as part of a growing body of studies that attempt to elucidate the role of interactional and discursive processes in the identification and management of disorders (Barrett 1988; Coulter 1975; Hak 1989; Pollner 1975; Smith 1978; Soyland 1994). Microsociological and ethnographic studies look at the properties of client-professional interaction with the aim of clarifying the tacit skills and knowledges used in such encounters. Palmer (2000), for example, argues that the recognition of disorder is a social and interactional issue both in the sense that the judgment of disorder is based on social criteria and in the sense that diagnosis is an interpersonal process with its own inherent social order. The aim, therefore, of analyzing professional-client interactions would be to articulate the properties of this implicit social order. Other researchers argue that diagnosis is not a process of identification or recognition of disorder, but rather a process of active construction of disorder and of transforming the person to a mental patient. Barrett's (1988) analysis of the transformation of a [End Page 87] person to a "person suffering from schizophrenia" and subsequently a "schizophrenic" through interviewing and report writing is an excellent example of this kind of work.The application of this approach to the field of delusions would attempt to address the issue of how delusions are diagnosed and managed through the interactions between the delusional patient and the clinician. In this paper and in previous work (Georgaca 1996, 2000) I showed that statements that have been diagnosed as delusional are presented and argued through using appropriate conversational strategies, drawing on socially meaningful systems of knowledge and applying appropriate rules of evidence. Moreover, I argued that there was no way in which these disagreements over competing versions of reality could be definitely settled conversationally, and that instances of breakdown in communication were due not to the delusional version being proven wrong, but to lack of explanatory frameworks within which the competing versions could be negotiated. At least in the exchanges analyzed, the criteria of implausibility, conviction, and incorrigibility were shown not to apply.Clinicians do not customarily investigate the truth of patient claims against empirical data (Maher 1992), which means that they have to judge claims on the basis of the patient's presentation in the diagnostic interview. Because there are no technical guidelines for the assessment of truth and falsity, plausibility and implausibility, rationality and irrationality, clinicians have to rely on personal judgment. The question then is on what grounds the clinician's personal judgment is granted the status of determining the truth of someone else's claim and in what capacity clinicians are called to make such decisions. I will not pursue this argument any further here. The point I want to make is that the analysis of professional-client interactions foregrounds the active role of professionals in clinical decisions and questions the criteria upon which decisions are... (shrink)

Franco Eugeni remembers Bruno Rizzi: in this brief introduction, I would like to remember an afternoon spent in “ Roma Tre ” with Bruno, since we were both Ordinary Professors at that University. We passed it doing a dense program of work for the next three years. At 6.00 pm, I left for “Roseto degli Abruzzi”. At six o'clock a.m. of the next morning, I still have the voice in my ears. A phone call from the Headmaster Ciro d'Aniello, who (...) told me " The Professor is dead" In that afternoon, Emilio Ambrisi and I went to Rome; we were stunned and desperate. Not many days later, a conference was held at the University of Teramo; it was the conference that we had prepared for Bruno, to celebrate his 60th birthday, but it was his memory. In the opening conference, Prof. Antonino Giambo, also fraternal friend of Bruno, burst into a tearful cry, which expressed in a moment, the senses of friendship and love that we all had for the missing friend! Starting from this work with Fabrizio Maturo, the study of some problems left open by the works of Eugeni and Rizzi will be investigated. Sunto Ricordo di Franco Eugeni su Bruno Rizzi: in questa brevissima introduzione vorrei ricordare un pomeriggio passato a Roma Tre con Bruno, visto che allora eravamo entrambi Professori Ordinari in quella Università. Lo passammo a fare un denso programma di lavoro per i successivi tre anni. Alle 18.00 ripartii per Roseto degli Abruzzi. Alle sei del mattino successivo, ho ancora la voce nelle orecchie, una telefonata del Preside Ciro d’Aniello, che mi diceva “ Il Professore è morto” Nel pomeriggio Emilio Ambrisi ed io ci recammo a Roma, eravamo attoniti e disperati. Non molti giorni dopo si tenne presso l’Università di Teramo un Convegno, era il Convegno che avevamo preparato per Bruno, per festeggiare i suoi 60 anni, fu invece il ricordo. Nella conferenza di apertura il prof. Antonino Giambò, anche lui, come noi, fraterno amico di Bruno, scoppiò in un pianto dirotto, che espresse in un attimo, i sensi dell’amicizia e dell’amore, che tutti noi avevamo per l’amico scomparso! A partire da questo lavoro con Fabrizio Maturo verrà approfondito lo studio di alcune problematiche rimaste aperte dai lavori di Eugeni e Rizzi. (shrink)

Volume 10, Issue 3, September 2019, Page 457-461.

In Western countries today, a growing number of women delay motherhood until their late 30s and even 40s, as they invest time in pursuing education and career goals before starting a family. This social trend results from greater gender equality and expanded opportunities for women and is influenced by the availability of contraception and assisted reproductive technologies. However, advanced maternal age is associated with increased health risks, including infertility. While individual medical solutions such as ART and elective egg freezing can (...) promote reproductive autonomy, they entail significant risks and limitations. We thus argue that women should be better informed regarding the risks of advanced maternal age and ART, and that these individual solutions need to be supplemented by a public health approach, including policy measures that provide women with the opportunity to start a family earlier in life without sacrificing personal career goals. (shrink)

According to social constructionism factuality, the establishment of accounts as corresponding to an objective external reality, is an interactional accomplishment ordinarily achieved in everyday conversations. In cases of disagreement regarding the interpretation and nature of events, however, not only the plausibility of the account, but also the rationality, integrity, and accountability of the participants is at stake. Delusions present extreme cases of such disagreement. This paper analyzes extracts from an interview with an individual diagnosed as delusional focusing on the factualization (...) devices used in the negotiation of accounts. The question of whether the observation of conversational rules documented in the interview is sufficient to establish the plausibility of an account and the rationality of its teller leads to arguments around the necessity of shifting the focus from the grounded micro-analysis of talk to wider social and institutional processes. (shrink)

Harvey and Gurvir’s Law is a bill proposed to the Legislative Assembly of Ontario (Canada) to reduce stigma and bias associated with Down syndrome, by developing and disseminating quality information about Down syndrome in the context of prenatal testing.

Conceptual analysis of health and disease is portrayed as consisting in the confrontation of a set of criteria—a “definition”—with a set of cases, called instances of either “health” or “ disease.” Apart from logical counter-arguments, there is no other way to refute an opponent’s definition than by providing counter-cases. As resorting to intensional stipulation is not forbidden, several contenders can therefore be deemed to have succeeded. This implies that conceptual analysis alone is not likely to decide between naturalism and normativism. (...) An alternative to this approach would be to examine whether the concept of disease can be naturalized. (shrink)

La conception traditionnelle des théories scientifiques en philosophie de langue anglaise, qu’on appelle la « received view », et qui culmine au début des années 1960, posait de nombreux obstacles à une conception des théories scientifiques en biologie et en médecine. La conception sémantique des théories scientifiques qui lui succéda permit de lever ces obstacles, mais pas de différencier les théories en biologie expérimentale et en médecine. Le présent article met en évidence comment, en s’appuyant sur cette conception, Schaffner établit (...) la spécificité des théories biologiques et médicales par rapport aux théories physiques, comment Thompson établit que c’est le savoir biologique et non le savoir clinique qui, véritablement théorique, fonde le caractère proprement scientifique de la médecine, et enfin, comment Sadegh-Zadeh peut proposer à son tour des caractéristiques des théories médicales qui leur sont potentiellement spécifiques et les distinguent des théories biologiques. (shrink)

This article explores the role of disgust in Kant’s aesthetic philosophy, Derrida’s deconstruction of Kant’s third Critique in his article 'Economimesis,' and the figure of vomit in two films by David Lynch in order to argue for the ethical possibilities of not giving ground relative to one’s disgust—what I term an ethics of the worse than the worst.

Following the neurophenomenological approach, we propose a model of emotional emergence that identifies the experimental structures of time involved in emotional experience and their plausible components in terms of cognition, physiology, and neuroscience. We argue that surprise, as a lived experience, and its physiological correlates of the startle reflex and cardiac defense are the core of the dynamic, and that the heart system sets temporally in motion the dynamic of emotional emergence. Finally, in reference to Craig’s model of emotion, we (...) propose an integrative model of the temporal dynamic of emotional emergence that allows emotions to be distinguished depending on each temporal phase and that involves the following three systems: the brain , the consciousness , and the doubled-sided continuum of the body-heart context, with the heart as the focus within the body during emotion. This model provides the framework for future developments in 1st- and 3rd-person approaches for an integrative understanding of the science of emotion, including the fields of psychophysiology and psychopathology. (shrink)

La réflexion sur l’éthique et la déontologie des médias en Afrique de l’Ouest suscite diverses questions. Il convient d’abord de clarifier les concepts pour alimenter le débat qui a ses moments forts, notamment pendant les périodes électorales.D’un côté, les professionnels de l’information, les acteurs des médias mettent l’accent sur la nécessaire liberté de la presse et peuvent être en porte-à-faux dans leur pratique avec la philosophie et les règles de la profession. D’un autre côté, différentes institutions, que ce soit les (...) institutions gouvernementales, la société civile ou de « simples » citoyens, s’appuient sur les médias, mais les interpellent au sujet d’une liberté qui ne saurait être sans responsabilité.Il s’agira donc de contextualiser l’environnement d’intervention des médias et d’examiner les réponses données aux problèmes posés y compris par les citoyens dans leurs rapports aux médias. La mise en place d’une législation et de structures institutionnelles – que ce soit les organes de régulation, dans leur diversité, ou de manière plus problématique, les organes d’autorégulation ou le tribunal des pairs – montre qu’il existe une dynamique à prendre en compte dans le dévelop­pement des médias en Afrique de l’Ouest.Enfin, nous nous attaquerons à quelques défis, qu’il s’agisse de la formation des professionnels, de la pratique des médias en période de conflit ou des technologies de l’information et de la communication, pour montrer que l’éthique et la déontologie sont au cœur du développement démocratique en Afrique de l’Ouest et en sont un élément constitutif. (shrink)

Our goal is to prove that the golden section, however important, is not the only key to understand a mathematical-formalizing approach to the idea of beauty. Having developed, from this point of view, reading keys linked to the post-modern, it is necessary to link together the multiple rivulets of knowledge that gather in this direction. Moreover the canons of the approaches presented up to now are very indicative for the understanding of many aspects of beauty, which however depends on the (...) historical moment and the cultures created in the various civilizations. Therefore we can affirm that there is no effective definition of "beauty" that can be codified through fixed canons, but that the concept is expressed by a series of stratifications and interpretations that tend to link several major variations, expressing the various answers given by man to the question: what is the beauty? (shrink)

En France, l'épistémologie de la médecine est facilement réduite à l'étude du magistral essai de Canguilhem, Le normal et le pathologique. Toutefois, ce livre publié il y a plus de soixante-dix ans ne reflète plus l'état des sciences médicales contemporaines, ni celui des débats poursuivis par les philosophes des sciences depuis. Le présent livre, premier du genre en langue française, a pour ambition d'introduire le lecteur à la philosophie des sciences médicales. Ses dix chapitres initieront le lecteur aux débats qui (...) l'agitent, sans que soient requises des connaissances philosophiques ou médicales préalables. Il répond à la fois à la demande de médecins en quête d'une philosophie qui leur parle de leur discipline et de leurs pratiques, et de philosophes à la recherche d'un guide dans ce champ morcelé et dominé par la philosophie d'expression anglaise. [Payot]. (shrink)

In this paper, we provide a macro level analysis of the visibility of philosophy of science in the sciences over the last four decades. Our quantitative analysis of publications and citations of philosophy of science papers, published in 17 main journals representing the discipline, contributes to the longstanding debate on the influence of philosophy of science on the sciences. It reveals the global structure of relationships that philosophy of science maintains with science, technology, engineering and mathematics and social sciences and (...) humanities fields. Explored at the level of disciplines, journals and authors, this analysis of the relations between philosophy of science and a large and diversified array of disciplines allows us to answer several questions: what is the degree of openness of various disciplines to the specialized knowledge produced in philosophy of science? Which STEM and SSH fields and journals have privileged ties with philosophy of science? What are the characteristics, in terms of citation and publication patterns, of authors who get their philosophy of science papers cited outside their field? Complementing existing qualitative inquiries on the influence of specific authors, concepts or topics of philosophy of science, the bibliometric approach proposed in this paper offers a comprehensive portrait of the multiple relationships that links philosophy of science to the sciences. (shrink)

(2009). To cut, to split, to touch, to eat, as of a body or a text. Angelaki: Vol. 14, shadows of cruelty sadism, masochism and the philosophical muse – part one, pp. 131-145.

All logic instruments and tools in possession of, and used by researchers are generally considered as the results of bivalent logic. A common error to people interested in science is that, usually, they don’t known with certainty which things are true and which are false. But they are sure that things are true or false. No ways in the middle. The fuzzy principle asserts that this is completely a question of measure. Fuzziness is the opposite concept to bivalency, while fuzzy (...) quality means polyvalency. Fuzzy logic is able to manage uncertain knowledge and, more precisely, to manage those rules difficult to formalize. In many cases, such rules haven’t got, or cannot have, the necessary precision, required for a whole formalization. (shrink)

According to the received view, the transportation view, animal extrapolation consists in inductive prediction of the outcome of a mechanism in a target, based on an analogical mechanism in a model. Through an analysis of the failure of preclinical studies of TGN1412, an innovative drug, to predict the tragic consequences of its first-in-man trial in 2006, the received view is challenged by a proposed view of animal extrapolation, the chimera view. According to this view, animal extrapolation is based on a (...) hypothesis about how human organisms work, supported by the amalgamation of results drawn from various experimental organisms, and only predicting the ‘predictive grid’, that is, a global framework of the effects to be expected. (shrink)

Science starts by using terms such as ‘temperature’ or ‘fish’ or ‘gene’ to preliminarily delimitate the extension of a phenomenon, and concludes by giving most of them a technical meaning based on an explanatory model. This transforma- tion of the meaning of the term is an essential part of its naturalization. Debating on the definition of ‘disease’, what most philosophers of medicine have examined is the pre-naturalized meaning of the term: for that reason they have focused on the task of (...) delimiting disease and non-disease (health), mainly used conceptual analysis as a method of choice, and considered the nosological level of ‘disease judgments’ rather than the pathophysiological or psychopathological level of disease mechanisms, thus making them impervious to most scientific discoveries. By focusing instead on the naturalized concept of disease and following some suggestions by philosophers of biology and scientists in cutting-edge fields of biomedical research, they could gar- ner results from a comparison of the mechanisms of diseases. This would ultimately result in a general theory of disease linked with our most general theories on living beings, among them, systems biology and network medicine. Before undertaking such a task, preliminary questions arise: is it likely that there are biological features common to different types of disease? Is it a philosopher’s job to determine what they consist in? What use would such a general theoretical definition of disease be? (shrink)

While many experts and organizations have recognized infertility as a public health issue, most governments have not yet adopted a public health approach to infertility. This article argues in favor of such an approach by discussing the various implications of infertility for public health. We use a conceptual framework that focuses on the dual meaning of the term ‘public’ in this context: the health of the public, as opposed to that of individuals, and the public/collective nature of the required interventions. (...) This analysis highlights the need for a comprehensive public health approach toward infertility, points to some initiatives that are already in place and demonstrates that prevention is currently a neglected—yet much needed——element. We move on to discuss the sensitive nature of prevention initiatives as a probable explanation for their scarcity. We illustrate the complexity of prevention through an analysis of an infertility prevention campaign previously conducted in the United States, which provoked significant controversy. We use a public health communication ethics framework to expose the strengths and the shortcomings of this campaign, and conclude that prevention initiatives targeting infertility can indeed be conducted in a sensible way that promotes autonomy while improving public health. (shrink)

Since the turn of the twenty-first century, biomedical psychiatry around the globe has embraced the so-called precision medicine paradigm, a model for medical research that uses innovative techniques for data collection and analysis to reevaluate traditional theories of disease. The goal of precision medicine is to improve diagnostics by restratifying the patient population on the basis of a deeper understanding of disease processes. This paper argues that precision is ill-fitting for psychiatry for two reasons. First, in psychiatry, unlike in fields (...) like oncology, precision medicine has been understood as an attempt to improve medicine by casting out, rather than merely revising, traditional taxonomic tools. Second, in psychiatry the term “biomarker” is often used in reference to signs or symptoms that allow patients to be classified and then matched with treatments; however, in oncology “biomarker” usually refers to a disease mechanism that is useful not only for diagnostics, but also for discovering causal pathways that drug therapies can target. Given these differences between how the precision medicine paradigm operates in psychiatry and in other medical fields like oncology, while precision psychiatry may offer successful rhetoric, it is not a promising paradigm. (shrink)

Despite its vagueness Personalized, Precision, P4, P5, individualized, stratified medicine—or p-medicine in short—has become an increasingly popular term in biomedical literature. Philosophers have attempted to analyze what these various terms involve and have discussed consequences for medical practices. In this article, I argue that an important question remains unaddressed: what has made this project of p-medicine convincing to so many? My argument is that without real achievements, it would never have been. I also make the case that these achievements stem (...) from the domain of monoclonal antibodies, a new type of drug that justifies talks of personalized, precise, stratified, etc., medicine. In conclusion, while it may be possible to label any projection in the future of medicine as ‘p-medicine’, it is impossible to overlook mab-medicine as the spearhead. (shrink)

Contrairement aux idées reçues, Hegel n’est pas un précurseur de la pensée totalitaire, auquel on pourrait opposer un Bergson républicain et démocrate. Tous deux parlent de la communauté politique comme d’un organisme, doctrine affectionnée du totalitarisme. Ni chez l’un, ni chez l’autre, on ne peut atténuer la portée de l’affirmation en invoquant un usage métaphorique : il faut entendre, chez l’un comme chez l’autre, l’organisme au sens propre mais large. L’organicité du politique, loin de la menacer, est la seule forme (...) compatible avec la liberté des individus, grâce à la distinction que l’on peut faire entre organisation toute faite et organisation se faisant : si la première traite les individus en rouages d’un mécanisme, la seconde est l’expression immédiate de l’épanouissement de leurs libertés.Popper wrote that Hegel, as a thinker, is a forerunner of totalitarianism ; on the other hand, one cannot but regard Bergson as a true democrat. Both however considered the politic body as an organism, a doctrine supporters of the totalitarian state favoured. The assertion must not be underrated : neither thinker intended to use a metaphorical expression, hence a broad meaning of « organism ». As a matter of fact the organicity of a politic body, far from threatening individual freedom, is the only form that proves compatible with individuality. The important thing is to distinguish all-made « organized organisation » from selfmaking « organizing organisation » : the former treats individuals as mechanical entities, while the latter is the result of the self-development of their freedom. (shrink)