Philosophers of neuroscience have traditionally described interfield integration using reduction models. Such models describe formal inferential relations between theories at different levels. I argue against reduction and for a mechanistic model of interfield integration. According to the mechanistic model, different fields integrate their research by adding constraints on a multilevel description of a mechanism. Mechanistic integration may occur at a given level or in the effort to build a theory that oscillates among several levels. I develop this alternative model using (...) a putative exemplar of reduction in contemporary neuroscience: the relationship between the psychological phenomena of learning and memory and the electrophysiological phenomenon known as Long-Term Potentiation. A new look at this historical episode reveals the relative virtues of the mechanistic model over reduction as an account of interfield integration. (shrink)

_Not exercising as much as you should? Counting your calories in your sleep? Feeling ashamed for not being happier? You may be a victim of the wellness syndrome._ In this ground-breaking new book, Carl Cederström and André Spicer argue that the ever-present pressure to maximize our wellness has started to work against us, making us feel worse and provoking us to withdraw into ourselves. The Wellness Syndrome follows health freaks who go to extremes to find the perfect diet, corporate (...) athletes who start the day with a dance party, and the self-trackers who monitor everything, including their own toilet habits. This is a world where feeling good has become indistinguishable from being good. Visions of social change have been reduced to dreams of individual transformation, political debate has been replaced by insipid moralising, and scientific evidence has been traded for new-age delusions. A lively and humorous diagnosis of the cult of wellness, this book is an indispensable guide for everyone suspicious of our relentless quest to be happier and healthier. (shrink)

This article examines and critiques the use of the term “vulnerability” in U.S. and international regulations and guidelines on research ethics. After concluding that the term is currently used in multiple, often inconsistent, senses, it calls on regulators to differentiate between three distinct types of vulnerability: “consent-based vulnerability,”“risk-based vulnerability,” and “justice-based vulnerability.”.

Jonathan Weisberg claims that certain probability assessments constructed by Jeffrey conditioning resist subsequent revision by a certain type of after-the-fact defeater of the reasons supporting those assessments, and that such conditioning is thus “inherently anti-holistic.” His analysis founders, however, in applying Jeffrey conditioning to a partition for which an essential rigidity condition clearly fails. Applied to an appropriate partition, Jeffrey conditioning is amenable to revision by the sort of after-the-fact defeaters considered by Weisberg in precisely the way that he demands.

For the greater part of the last 50 years, it has been common for philosophers of mind and cognitive scientists to invoke the notion of realization in discussing the relationship between the mind and the brain. In traditional philosophy of mind, mental states are said to be realized, instantiated, or implemented in brain states. Artificial intelligence is sometimes described as the attempt either to model or to actually construct systems that realize some of the same psychological abilities that we and (...) other living creatures possess. The claim that specific psychological. (shrink)

It is a common assumption in contemporary cognitive neuroscience that discovering a putative realized kind to be dissociably realized (i.e., to be realized in each instance by two or more distinct realizers) mandates splitting that kind. Here I explore some limits on this inference using two deceptively similar examples: the dissociation of declarative and procedural memory and Ramachandran's argument that the self is an illusion.

Suppose that several individuals who have separately assessed prior probability distributions over a set of possible states of the world wish to pool their individual distributions into a single group distribution, while taking into account jointly perceived new evidence. They have the option of first updating their individual priors and then pooling the resulting posteriors or first pooling their priors and then updating the resulting group prior. If the pooling method that they employ is such that they arrive at the (...) same final distribution in both cases, the method is said to be externally Bayesian, a property first studied by Madansky . We show that a pooling method for discrete distributions is externally Bayesian if and only if it commutes with Jeffrey conditioning, parameterized in terms of certain ratios of new to old odds, as in Wagner , rather than in terms of the posterior probabilities of members of the disjoint family of events on which such conditioning originates. (shrink)

What are the relative epistemic merits of building prosthetic models versus building nonprosthetic models and simulations? I argue that prosthetic models provide a sufficient test of affordance validity, that is, of whether the target system affords mechanisms that can be commandeered by a prosthesis. In other respects, prosthetic models are epistemically on par with nonprosthetic models. I focus on prosthetics in neuroscience, but the results are general. The goal of understanding how brain mechanisms work under ecologically and physiologically relevant conditions (...) is narrow compared to the search for maker's knowledge about how the brain can be made to work for us. (shrink)

This paper gives a formalization of general topology in second-order arithmetic using countably based MF spaces. This formalization is used to study the reverse mathematics of general topology. For each poset P we let MF denote the set of maximal filters on P endowed with the topology generated by {Np | p ∈ P}, where Np = {F ∈ MF | p ∈ F}. We define a countably based MF space to be a space of the form MF for some (...) countable poset P. The class of countably based MF spaces includes all complete separable metric spaces as well as many nonmetrizable spaces. The following reverse mathematics results are obtained. The proposition that every nonempty Gδ subset of a countably based MF space is homeomorphic to a countably based MF space is equivalent to [Formula: see text] over ACA0. The proposition that every uncountable closed subset of a countably based MF space contains a perfect set is equivalent over [Formula: see text] to the proposition that [Formula: see text] is countable for all A ⊆ ℕ. The proposition that every regular countably based MF space is homeomorphic to a complete separable metric space is equivalent to [Formula: see text] over [Formula: see text]. (shrink)

Infinite time register machines (ITRMs) are register machines which act on natural numbers and which are allowed to run for arbitrarily many ordinal steps. Successor steps are determined by standard register machine commands. At limit times register contents are defined by appropriate limit operations. In this paper, we examine the ITRMs introduced by the third and fourth author (Koepke and Miller in Logic and Theory of Algorithms LNCS, pp. 306–315, 2008), where a register content at a limit time is set (...) to the lim inf of previous register contents if that limit is finite; otherwise the register is reset to 0. The theory of these machines has several similarities to the infinite time Turing machines (ITTMs) of Hamkins and Lewis. The machines can decide all ${\Pi^1_1}$ sets, yet are strictly weaker than ITTMs. As in the ITTM situation, we introduce a notion of ITRM-clockable ordinals corresponding to the running times of computations. These form a transitive initial segment of the ordinals. Furthermore we prove a Lost Melody theorem: there is a real r such that there is a program P that halts on the empty input for all oracle contents and outputs 1 iff the oracle number is r, but no program can decide for every natural number n whether or not ${n \in r}$ with the empty oracle. In an earlier paper, the third author considered another type of machines where registers were not reset at infinite lim inf’s and he called them infinite time register machines. Because the resetting machines correspond much better to ITTMs we hold that in future the resetting register machines should be called ITRMs. (shrink)

Environmentalists have advocated the Precautionary Principle (PP) to help guide public and private decisions about the environment. By contrast, industry and its spokesmen have opposed this. There is not one principle, but many that have been recommended for this purpose. Despite the attractiveness of a core idea in all versions of the principle—that decision-makers should take some precautionary steps to ensure that threats of serious and irreversible damage to the environment and public health do not materialize into harm—even one of (...) the most widely endorsed principles needs considerable specification and refinement before it can be used. Moreover, the PP is an approach or guide to utilizing scientific evidence in social or legal decision-making contexts. In this it does not differ in kind from other approaches to using factual information such as in the law. The law provides some models for different strategies to guide decision-making under uncertainty when factual issues cannot be resolved with certainty. These in turn can help guide the formulation of different versions of PP and help clarify some presuppositions of the principle. Once some plausible versions of PP are articulated, I suggest some applications to existing environmental problems. (shrink)

Garber (1983) and Jeffrey (1991, 1995) have both proposed solutions to the old evidence problem. Jeffrey's solution, based on a new probability revision method called reparation, has been generalized to the case of uncertain old evidence and probabilistic new explanation in Wagner 1997, 1999. The present paper reformulates some of the latter work, highlighting the central role of Bayes factors and their associated uniformity principle, and extending the analysis to the case in which an hypothesis bears on a countable family (...) of evidentiary propositions. This extension shows that no Garber-type approach is capable of reproducing the results of generalized reparation. (shrink)

A simple rule of probability revision ensures that the final result of a sequence of probability revisions is undisturbed by an alteration in the temporal order of the learning prompting those revisions. This Uniformity Rule dictates that identical learning be reflected in identical ratios of certain new-to-old odds, and is grounded in the old Bayesian idea that such ratios represent what is learned from new experience alone, with prior probabilities factored out. The main theorem of this paper includes as special (...) cases Field's theorem on commuting probability-kinematical revisions and the equivalence of two strategies for generalizing Jeffrey 's solution to the old evidence problem to the case of uncertain old evidence and probabilistic new explanation. (shrink)

The question of legalizing physician-assisted suicide has become a serious public debate. Growing interest in assisted suicide reflects a public increasingly fearful of the process of dying, particularly the prospect of dying a painful, protracted, or undignified death. PAS has been proposed as a compassionate response to unrelievable suffering, designed to give terminally or incurably ill individuals direct control over the timing, manner, and circumstances of their death. Although the American Medical Association remains firmly opposed to legalizing PAS, many physicians (...) have begun to express support for the practice, and some have acknowledged that they have helped patients commit suicide despite the existing legal ban.As support for PAS grows, it becomes increasingly likely that the practice will be legalized in at least some states in the not-too-distant future. In 1994, Oregon voters approved a referendum legalizing PAS for competent, terminally ill patients; a federal court injunction preventing the referendum from going into effect is currently on appeal, and it is widely expected that the injunction will be lifted. (shrink)

In 1988, Michael Nyman composed the score for Peter Greenaway’s film Drowning by Numbers (or did something that we would ordinarily think of as composing that score). We can think of Nyman’s compositional activity as a “generative performance” and of the sound structure that Nyman indicated (or of some other abstract object that is appropriately related to that sound structure) as the product generated by that performance (ix).1 According to one view, Nyman’s score for Drowning by the Numbers—the musical work—is (...) the product generated by Nyman’s compositional activity (namely, an abstract object) and, more generally, artworks are identified with the products generated by compositional or other creative activities. Let’s call this view The Product Theory. By contrast, according to another view, Nyman’s score for Drowning by Numbers is the generative performance itself (namely, Nyman’s compositional activity) and, more generally, artworks are identified with generative performances themselves. Following David Davies in Art as Performance, let’s call this view The Performance Theory (80). In that book, Davies argues for The Performance Theory and against The Product Theory. (shrink)

I believe that some instances of civil disobedience are justifiable, even in a reasonably healthy democracy. This is a proposition with which most persons are inclined to agree intuitively, I think, and may therefore appear to be in no need of defense. In fact, however, the presentation of a solid defense of that thesis would be so complicated, and so inextricably entwined with factual questions about the circumstances in which the disobedience in question takes place, that I shall not even (...) attempt to provide it here. The provision of that defense is one ultimate object of mine, however, and my present purpose is to advance toward it by examining certain critical arguments that the defense of civil disobedience must meet. My aim here is to show that the major arguments, which are designed to establish the unjustifiability of civil disobedience, do not do that. (shrink)

Racial preferences are among the most contentious issues in our society, touching on fundamental questions of fairness and the proper role of racial categories in government action. Now two contemporary philosophers, in a lively debate, lay out the arguments on each side. Carl Cohen, a key figure in the University of Michigan Supreme Court cases, argues that racial preferences are morally wrong--forbidden by the 14th Amendment to the Constitution, and explicitly banned by the Civil Rights Act of 1964. He (...) also contends that such preferences harm society in general, damage the universities that use them, and undermine the minorities they were intended to serve. James P. Sterba counters that, far from being banned by the Constitution and the civil rights acts, affirmative action is actually mandated by law in the pursuit of a society that is racially and sexually just. The same Congress that adopted the 14th Amendment, he notes, passed race-specific laws that extended aid to blacks. Indeed, there are various kinds of affirmative action--compensation for past discrimination, remedial measures aimed at current discrimination, the guarantee of diversity--and Sterba reviews the Supreme Court cases that build a constitutional foundation for each. Affirmative action, he argues, favors qualified minority candidates, not unqualified ones. Both authors offer concluding comment on the University of Michigan cases decided in 2003. Half a century after Brown v. Board of Education, issues pertaining to racial discrimination continue to grip American society. Ideal for courses in political, social, ethical, and legal philosophy, this penetrating debate explores the philosophical and legal arguments on all sides of affirmative action, but also reveals the passions that drive the issue to the forefront of public life. (shrink)

Jeffrey conditionalization is generalized to the case in which new evidence bounds the possible revisions of a prior below by a Dempsterian lower probability. Classical probability kinematics arises within this generalization as the special case in which the evidentiary focal elements of the bounding lower probability are pairwise disjoint.

While David Hume explicitly elaborated on the development of a modern commercial society in the Political Discourses and the History of England, it is more difficult to discern whether Hume had a specific time period or societal transformation in mind when he laid out his political philosophy in A Treatise of Human Nature. In the Treatise, Hume unambiguously states that he did not believe in the existence of a pre-social stage of human development—he considered such elaborations mere philosophical fiction. The (...) lack of an abrupt demarcation between the pre-social and the social in Hume's thought makes his political philosophy incongruent with an original contract or a first social formation. In this sense, Hume's social theory might be considered a foundational theory for all human coexistence and the Treatise would thus read as an ahistorical text. However, it is plausible that Hume was instead providing a discussion of a particular historical transformation—that of commercial modernization—by emphasizing the construction of a new set of social institutions and ignoring or downplaying the social forms that came before. This paper challenges the ahistorical interpretations and suggests that Hume was indeed providing a philosophical elaboration of the. (shrink)

Can a man intend to do the impossible? That is, can a man undertake to do some action, A—and not merely to come as close as possible to doing A with the hope that the doing of A will result—when he believes he has no chance of doing A?

ABSTRACT The paper is a discussion of moral responsibility and excuses in regard to psychiatric disorders involving abnormal desires (e.g. impulse control disorders such as kleptomania and pyromania, psychosexual disorders such as exhibitionism, obsessive‐compulsive disorder and others). It points out problems with previous approaches to the question of whether or not to excuse persons with these disorders, and offers a new approach based on the concept of duress. There is a discussion of duress in regard to non‐psychiatric cases based on (...) the core notion of duress involving a choice between undesirables, and the paper concludes with an argument that moral blame for individuals with these sorts of disorders should often be lessened and in some cases removed entirely. (shrink)

It is argued that the tensed theory of the creative subject provides a natural formulation of the logic underlying Brouwer's notion of unextendable order and explains the link between that notion and virtual order. The tensed theory of the creative subject is also shown to be a useful tool for interpreting recent evidence about the stages of Brouwer's thinking concerning these two notions of order.

Among the many explanations for antibiotic overprescription, some doctors cite the risk of malpractice liability if they deny a patient's request for an antibiotic and the patient's condition worsens. In this paper, I examine the merits of this concern—i.e., whether physicians could, in fact, face malpractice liability for refusing to prescribe an antibiotic when, from a public health perspective, the use of the antibiotic would be considered inappropriate. I conclude that the potential for liability cannot be dismissed entirely, but the (...) risk is remote—even in cases where there is a chance that the antibiotic might have benefited the patient. (shrink)