The focus on translational research in clinical trials has the potential to generate clinically relevant genetic data that could have importance to patients. This raises challenging questions about communicating relevant genetic research results to individual patients. An exploratory pharmacogenetic analysis was conducted in the international ovarian cancer phase III trial, AGO-OVAR 16, which found that patients with clinically important germ-line BRCA1/2 mutations had improved progression-free survival prognosis. Mechanisms to communicate BRCA results were evaluated, because these findings may be beneficial to (...) patients and their families. Communicating individual BRCA results was not anticipated during clinical trial design. Consequently, options were not available for patients to indicate their preference for receiving their individual results when they signed pharmacogenetic informed consent. Differences in local requirements, clinical practice, and opinion regarding the ethical aspects of how to convey genetic results to patients are all potential barriers to returning individual BRCA results to patients. Communicating the aggregate BRCA result from this study provided clinical investigators with a mechanism to disseminate the overall study finding to patients while taking individual circumstances, local guidelines and clinical practice into account. This study illustrates the importance of increasing the clarity and scope of informed consent and the need for patient engagement to ensure clinical trial participants can indicate their preference regarding receipt of potentially important individual pharmacogenetic results. This study was registered in the NCT Clinical Trial Registry under NCT00866697 on March 19, 2009, following approval from participating ethics committees. (shrink)

There are countless circumstances under which random individuals COULD act together to prevent something morally bad from happening or to remedy a morally bad situation. But when OUGHT individuals to act together in order to bring about a morally important outcome? Building on Philip Pettit’s and David Schweikard’s account of joint action, I will put forward the notion of joint duties: duties to perform an action together that individuals in so-called random or unstructured groups can jointly hold. I will show (...) how this account of joint duties is preferable to one which defends individual duties to cooperate. I then discuss the limits of joint duties and the ways in which one can fail to comply with them. It will become apparent that the circumstances under which individuals in random collectives acquire such joint duties are rare. (shrink)

"Deleuze plonge la critique kantienne transcendantale dans le bain dissolvant d'un empirisme renouvelé. Ce livre se propose de restituer cette entreprise, et d'analyser l'étonnante création de ce concept, que Deleuze mène depuis ses premières monographies jusqu'à Différence et Répétition dans un dialogue fécond avec l'histoire de la philosophie. Par quelles opérations de distorsion et de collage, Deleuze compose-t-il l'empirisme de Hume, la théorie du signe comme force de Nietzsche, le virtuel et les multiplicités de Bergson, les modes de Spinoza, les (...) individualisations impersonnelles de Simondon pour renouveler la théorie kantienne du transcendantal? C'est tout l'objet de cette enquête, qui permet d'entrer dans le laboratoire du penseur, pour saisir la philosophie se faisant, mais qui permet également d'expliquer l'insistance du transcendantal dans toute son oeuvre"--P. [4] of cover. (shrink)

The most remarkable about the continuity in Chomsky's thought about language is that it takes place against a theoretical landscape in constant flux, the landscape of generative grammar. Chomsky introduced a central distinction between E‐languages and I‐language, the internalized knowledge of language that each speaker has and which is the result of the interaction between his or her language faculty and the (limited) experience that he or she had of his or her mother tongue during language acquisition. The Faculty of (...) Language narrowly understood corresponds to “the abstract linguistic computational system alone, independent of the other systems with which it interacts”. This chapter aims to follow the trail of Chomsky's strongly reiterated claim throughout the years that language is not primarily a tool for communication, but rather, a tool for thought. (shrink)

Our moral obligations can sometimes be collective in nature: They can jointly attach to two or more agents in that neither agent has that obligation on their own, but they – in some sense – share it or have it in common. In order for two or more agents to jointly hold an obligation to address some joint necessity problem they must have joint ability to address that problem. Joint ability is highly context-dependent and particularly sensitive to shared (or even (...) common) beliefs. As such, joint ability can be deliberately generated in a given collection of agents by providing information related to collective goals and contributory actions. As moral agents, we regularly face problems wherein the outcome of our actions depends on how others choose. There are two ways of deliberating about our own choices in such cases. We can either think of our choices as best responses to others’ choices (I-mode reasoning). Or we can think of our own choices as contributions to the collectively best option (even when we do not know how others are (likely) to choose) (we-mode reasoning). In deliberating about the right (individual) course of action vis-à-vis collective action problems, agents regularly we-frame the case at hand, that is, they include options in their deliberation that are only collectively available, and they we-reason with regard to their individual contributory actions. It is a necessary condition for collective obligations that potential collaborators facing a joint necessity case have grounds to privilege we-reasoning over reasoning in I-mode. (shrink)

Prison work creates ethical challenges for which a training program was initiated for Dutch prison staff to foster their Moral Craftsmanship (MCS). The concept of MCS is not yet defined and operationalized in literature. This explorative study aims to 1) define MCS, 2) identify conceptual elements of MCS, and 3) develop a measurement tool for MCS. A document and literature study provided input for the definition and selection of conceptual elements related within DCIA policy documents, identifying three conceptual levels of (...) MCS: individual (cognition, attitude, and actions), team, and leadership. This first MCSQ consists of seventy-one items distributed across the domains: values and norms, judgment and reasoning, consultation, implementation, looking back, interactions, and leadership. We tested its usability via ‘think-aloud interviews.’ Validation of the current version of the MCS-Questionnaire and consensus among experts about what to include or exclude in the concept of MCS are needed for further development. (shrink)

School-based education in England has undergone significant changes since 2010, with a huge expansion of academies, schools outside local authority control, funded directly by central government. Academies and local authority (LA) maintained schools are subject to different legislative and regulatory frameworks. This paper focuses on the governance of LA maintained schools, single academy trusts (SATs) and schools that are part of multi-academy trusts (MATs). The research involved analysing legislative provision, policy documents, and documents addressing the governance arrangements of a sample (...) of 23 secondary schools. Our findings reveal a fragmented state-funded secondary school system as regards overall governance, school admissions, the curriculum, and the use of funding. Significantly schools in MATs, which are governed by the trust board, lack the autonomy of either SATs or maintained schools and are instead under the ultimate control of the trust board. The paper argues that there is a need for greater consistency regarding the governance of state-funded schools. (shrink)

This book explores the way in which, working within the investigative tradition associated with the Royal Society, the philosopher John Locke (1632-1704) used ...

Think Like an Economist is a fun introduction to the main concepts of economics. It illustrates how the subject has a clear, practical purpose vital to our daily lives and thinking; includes stories of many of the world's greatest economists; and covers the history of economics from the early barter system through the Industrial Revolution to the emergence of globalization.

A reference volume and playful devotional object based on the author's research into color theory informed by psychology, mysticism, and early modernism. The Color-Word Value Index has 44 word pairings; 10 colors; 5 suits; and values of positive, negative, and neutral"--Women's Studio Workshop website, viewed December 14, 2021.

In close collaboration with the late Matthew Lipman, Ann Margaret Sharp pioneered the theory and practice of 'the community of philosophical inquiry' (CPI) as a way of practicing 'Philosophy for Children' and prepared thousands of philosophers and teachers throughout the world in this practice. In Community of Inquiry with Ann Margaret Sharp represents a long-awaited and much-needed anthology of Sharp's insightful and influential scholarship, bringing her enduring legacy to new generations of academics, postgraduate students and researchers in the fields of (...) education, philosophy, philosophy of education, Philosophy for Children and philosophy of childhood. Sharp developed a unique perspective on the interdependence of education, philosophy, personhood and community that remains influential in many parts of the world. This perspective was shaped not only by Sharp's work in philosophy and education, but also by her avid studies in literature, feminism, aesthetic theory and ecumenical spirituality. Containing valuable contributions from senior figures in the fields in which Sharp produced her most focused scholarship, the chapters in this book present a critical overview of how Sharp's ideas relate to education, philosophy of education, and the Philosophy for Children movement as a whole. The historical and philosophical nature of this collection means that it will be a vital resource for philosophers and educators. It should also be of great interest to teacher educators and those involved in the study of pragmatism and feminism, as well as the history of education across the globe, particularly in the United States of America. (shrink)

The effects of non-standard Philosophy on Epistemelogy.

Was passiert, wenn die Bevölkerung die Möglichkeit erhält, sich ungeschminkt und ungefiltert zu bioethischen Problemstellungen zu äußern?

This book offers a philosophical analysis of what it is to be a human being in all her aspects. It analyses what is meant by the self and the I and how this feeling of a self or an I is connected to the brain. It studies specific cases of brain disorders, based on the idea that in order to understand the common, one has to study the specific. The book shows how the self is thought of as a three-fold (...) emergent self, comprising a relationship between an objective neural segment, a subjective neural segment and a subjective transcendent segment. It explains that the self in the world tackles philosophical problems such as the problem of free will, the problem of evil, the problem of human uniqueness and empathy. It demonstrates how the problem of time also has its place here. For many people, the world includes ultimate reality; hence the book provides an analysis and evaluation of different relationships between human beings and Ultimate Reality (God). The book presents an answer to the philosophical problem of how one could understand divine action in the world. (shrink)

Visual Arts Practice and Affect brings together a group of artist scholars to explore how visual arts can offer unique insights into the understanding of place, memory and affect. Each contributor highlights the crucial role the creative arts play in envisaging new perspectives on the making of meaning, ones that are grounded in the practicalities, materialities and embodied knowing of artistic practice. Art offers other ways of seeing, thinking, understanding the world. It can be very messy, very challenging, but also (...) moving, exquisite, astounding. The book opens a space for experiential appreciation by offering a writing that allows both the writer and the reader to consider those sorts of embodied sensibilities. (shrink)

This comprehensive Research Handbook explores the wide variety of work conducted in legal semiotics, providing a thorough understanding of how the law works through signs and symbols. Demonstrating that the law is a strategical system of fluctuating signs, contributors critically analyse the ever-evolving conceptualisations of law and legal discourse. Bringing together leading international experts, this Research Handbook focuses on the material, everyday forms of law comprised by non-verbal legal semiotics. Contributors conduct culturally nuanced semiotic analyses of the modern world, covering (...) topics from COVID-19, religion, and human rights, to comic books and music. Chapters consider the foundations of semiotics, as well as the philosophy of law, identifying the cross-cultural similarities in how legal semiotics and visual legal semiotics intersect. Ultimately, the Research Handbook demonstrates that the law is in a state of perpetual flux, with many unique dimensions only made visible by semiotic analysis. The Research Handbook on Legal Semiotics will be an invaluable resource for students and scholars of law, jurisprudence, legal culture, linguistics, and semiotics. It will also be an important guide for legal practitioners seeking to better understand the nuances of the legal system. (shrink)

Contemplating friendship in Aristotle's Ethics -- Teleology, inequality and autonomy -- Moral virtue: possibilities and limits -- Justice: giving to each what is owed -- Intellectual virtue, Akrasia and political philosophy -- Citizens, friends and philosophers -- Happiness and maternal contemplation.

The examined life -- What is there? -- Is there a God? -- What is it to be human? -- What can we know? -- How should we live? -- How do we make a good society? -- At the end of the day.

Philosophen, Theologen und Soziologen deuteten in der ersten Hälfte des 20. Jahrhunderts die Technik als ein die gesamte Lebenswirklichkeit prägendes Phänomen. Dabei entwickelten sie sehr unterschiedliche Positionen. Walter Benjamin sah in der Technik einen Weg, die Wirklichkeit neu zu konstruieren; Rudolf Bultmann nahm die Technik zum Anlass, das Transzendente neu zu bestimmen. Der Band bietet in Teil I Rekonstruktionen klassischer Positionen der Technikdeutung: Max Weber, Ernst Troeltsch, Paul Tillich, Rudolf Bultmann, Dietrich Bonhoeffer, Walter Benjamin, Martin Heidegger. Die Beiträge in Teil (...) II des Bandes thematisieren neuere theologische Zugänge zur Technik. (shrink)

Introduction: Aristotle's phantasia and the ancient concept of imagination -- Visualization, vividness (enargeia) and realism -- Mathematical projection, copying and analogy -- Prophecy, inspiration and allegory -- Conclusion: ancient and modern imagination.

Un commerce intime, tantot exalte, tantot inavouable, entre l'oeuvre de Proust et celles de Merleau-Ponty, Sartre, Deleuze ou Barthes se joue au coeur des annees 1950-1970, au moment ou sont renouvelees les facons d'envisager la production theorique. Si le romancier les a particulierement captives, c'est que son oeuvre venait amplifier ou heurter non seulement leur pratique reflexive, mais le sens meme de leur existence et de leur engagement dans l'ecriture. Du roman au traite, de la vie de l'un a la (...) vie de l'autre, nait une etrange erotique des pensees, ou se creent des partages sereins, des negociations passionnees, des appariements effrayants. Trafics de Proust opere un enfoncement dans la duree longue de ces echanges, de ces prets sur gages et de ces resiliations. Son enjeu est de rendre compte des strategies qui menent un penseur lisant Proust a construire ou deconstruire ses cadres cognitifs, a s'articuler, dans la fluidite du jeu ou le coincement grincant, a une vie de la pensee ou (de)raison, emotion et fiction consonnent avec individuation. Sont ainsi restituees des pensees sensibles, comme autant de formes de soi traversees par le romanesque. (shrink)

Avant et pendant la Première Guerre mondiale, en Occident, ont fleuri des mouvements qui, parce qu'ils ont conjointement revendiqué un renouvellement radical des pratiques artistiques et une remise en question sociale plus large, ont a posteriori été appelés «avant-gardes». Ce sont ces mouvements qui, du futurisme italien à dada en passant par le futurisme russe, l'imagisme et le vorticisme, sont au centre de cet ouvrage. Aucun, au moment de sa fondation, ne s'est pensé d'«avant-garde». Tous ont en commun de s'être (...) définis sur le mode de l'action collective, d'avoir été fondés en tant que groupes et de s'être pensés les uns par rapport aux autres. L'analyse fait émerger, dans le contexte de la modernité et du modernisme occidentaux du premier XXe siècle, la spécificité de ces mouvements autoproclamés, qui les distingue à la fois d'auteurs individuels d'«avant-garde» qui ne se sont jamais reconnus dans aucun mouvement et aussi d'autres groupes contemporains qui ne se sont pas autoproclamés tels - le vorticisme vs Bloomsbury, le cubisme ou l'expressionnisme vs le futurisme ou le dadaïsme. (shrink)

Medicine, Power, and the Law demonstrates that criminal and civil justice interact with medicine and public health more than is presently understood. The book focuses on the role of healthcare practitioners and an array of other professionals across industries in identifying wrongdoers, reporting behavior, and testifying on behalf of the state or government agencies. It also covers circumstances in which law enforcement relies on medicine for evidence or support in ways that compromise medical ethics. By reporting or testifying as experts, (...) a range of people, from specialist pediatricians to flight attendants, can have a life-changing impact on individuals in the name of public health or medicine. People who work in hospitals, social work settings, and even airlines, often contribute to wrongful and aggressive criminal and civil actions against society's most vulnerable people, including parents, older adults, and people living with poverty. The book explores a number of examples, including police use of medicine as a restraint or the collection of blood as evidence and the risks of opting out of certain scientific discoveries, such as pharmaceuticals. It describes the harms that may come to those who engage in suboptimal but generally heretofore legal child-raising behaviors, and people opting to live independently as older adults. These can lead to civil and criminal charges when noticed by those in a position of power. Medicine, Power, and the Law is an important contribution for researchers and practitioners in medicine, the law, and the expanding field of bioethics. (shrink)

In this chapter I investigate the kinds of changes that psychiatric kinds undergo when they become explanatory targets of areas of sciences that are not “mature” and are in the early stages of discovering mechanisms. The two areas of science that are the targets of my analysis are cognitive neuroscience and cognitive neurobiology.

This paper offers a critique of an account of explanatory integration that claims that explanations of cognitive capacities by functional analyses and mechanistic explanations can be seamlessly integrated. It is shown that achieving such explanatory integration requires that the terms designating cognitive capacities in the two forms of explanation are stable but that experimental practice in the mind-brain sciences currently is not directed at achieving such stability. A positive proposal for changing experimental practice so as to promote such stability is (...) put forward and its implications for explanatory integration are briefly considered. (shrink)

Der von Anne Tilkorn herausgegebene Sammelband Kant und Spinoza. Motivationen fur das Selbst beschaftigt sich mit den verborgenen Gemeinsamkeiten der beiden Philosophen in ihren Letztbegrundungen fur moralisches Handeln. Im Mittelpunkt stehen dabei die Begriffe der Selbstreferenz und Freiheit. Die Beitrage gehen den Folgen der sowohl bei Kant als auch bei Spinoza anzutreffenden Grundannahme einer "Ent-Aristotelisierung" auf dem Gebiet der Motivationstheorien, also der praktischen Philosophie nach. Dass zum Handeln auch eine Motivation gehort, ist fur beide Denker klar. Spinoza wie Kant (...) wussten um die Relevanz des Gefuhls - nicht als Fundament einer Moral, aber als notwendiger Beweggrund fur den Vollzug des moralischen Tuns. Und sie haben des Ofteren dieselbe Einschatzung hinsichtlich des Stellenwerts bestimmter Gefuhle: So sehen sie beide im Mitleid eine Schwache und keine Tugend, von beiden Philosophen ist der Ausspruch "Die Tugend ist ihr eigener Lohn" bekannt. Doch wo begegnen sich ihre Theoriestrukturen? Trotz der auf den ersten Blick so grossen Differenzen - Spinozas Determinismus versus Kants freier Wille, Spinozas Ansatz einer Einheit von Theorie und Praxis versus Kants strikte Unterscheidung zwischen theoretischer und praktischer Vernunft - lassen sich viele kongruente Linien in ihren Argumenten entdecken, die nun in fundierten Einzelstudien herausgestellt werden. (shrink)

Immortalité de l'âme, intelligence, distinction des substances, vie éternelle: ces questions, qui sont au coeur de la réflexion sur la nature de l'être humain, ont passionné les philosophes et les lettrés du Grand Siècle et du Siècle des Lumières. Un débat animé, polémique, s'est noué dans toute l'Europe savante et, notamment, de part et d'autre de la Manche. Avec pour fil conducteur l'émergence d'une conception laïque et matérielle de l'être humain, Ann Thomson nous fait partager l'effervescence féconde de ces échanges (...) et de ces débats. Elle nous initie aux polémiques théologico-politiques qui ont nourri la "crise de la conscience européenne" et ses prolongements, jusqu'au milieu du XVIIIesiècle. Consacrée à l'Angleterre après la Glorieuse Révolution de 1688, la première partie analyse les luttes idéologiques et religieuses de la fin du XVIIe et du début du XVIIIe siècle, replacées dans leur contexte historique, philosophique et scientifique, avant d'étudier la controverse sur Dieu, sur l'âme et sur la nature humaine. La deuxième partie, centrée sur les "premières Lumières" françaises, suit le cheminement des échos de ces controverses anglaises transmis par les passeurs huguenots et les voies clandestines de la circulation philosophique, puis analyse la spéculation scientifique et philosophique dans la première moitié du XVIIIe siècle. Ces vifs débats ont fait naître de multiples courants qui ont permis l'éclosion et l'épanouissement d'une pensée matérialiste qui s'affirma à partir des années 1760, dans le cadre, notamment, dune réflexion sur la génération. En soulignant le rôle joué par les polémiques théologiques protestantes mais également par la recherche médicale, cet essai d'histoire intellectuelle, transnationale, nous transporte au coeur de la philosophie des Lumières, et des "Lumières radicales". En même temps, il s'inscrit clans une histoire de longue durée, car les questions soulevées par ce livre continuent aujourd'hui d'interpeller les théologiens, les philosophes, les anthropologues, les neurobiologistes. Les penseurs des Lumières furent aux avant-postes d'une vertigineuse interrogation sur l'identité et la nature de l'homme. Pour la première fois, ce livre nous permet d'en explorer toutes les dimensions. (shrink)