SummaryJudith Montefiore's life has attracted attention principally by association with that of her husband Sir Moses Montefiore (1784–1885), the pre-eminent Jewish figure of his age. This article emphasises instead Judith's pioneering role as a Jewish woman travel-writer and influential female voice in the world of Jewish letters and international Jewish politics. To Jews in the Holy Cities of Palestine and the ghettos and shtetls of Eastern Europe, Judith was—like her husband—a beacon of hope, an example to follow and an instrument (...) of change. Her activities drew on a rich vein of Jewish tradition and a series of profound encounters with Middle Eastern and, to a lesser extent, Eastern European Jewries, which shaped her spiritual world. These paradoxes are easily conceptualised by the contrast between Judith's different worlds: the Jewish world that underpinned her marriage, structured her spirituality and infused her life with meaning, and the world of the English gentry and dissenting middle classes, with whom she mixed socially, and whose spiritual style, values, expectations, and mode of life shaped her in other, equally profound ways. This article argues, however, that it was the interaction and cross-fertilisation between these different worlds that enabled Judith to carve her distinctive path in life. (shrink)

This book updates and adds to the classic Social Movements of the Sixties and Seventies, showing how social movement theory has grown and changed.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Catharine Macaulay's Republican Enlightenment by Karen GreenAlan CoffeeKaren Green. Catharine Macaulay's Republican Enlightenment. London: Routledge, 2020. Pp. 276. Hardback, $160.00.Though she was once one of the most recognizable and celebrated public intellectuals in Britain and was read avidly in both revolutionary America and France, after her death in 1791, Catharine Macaulay's work fell into almost total obscurity for around two hundred years. This began to change in (...) the 1990s, since which time interest in Macaulay from historians, philosophers, and feminist scholars has gathered pace. In the last decade and a half, no one has likely done more to advance this scholarship than Karen Green, who has published numerous journal articles and book chapters probing deeply into Macaulay's thought and intellectual context, and who helpfully edited The Correspondence of Catharine Macaulay (Oxford: Oxford University Press, 2019), which had not previously been easily available to readers. As one would expect, Green's Catharine Macaulay's Republican Enlightenment builds on this depth of research. For a relatively slim volume, this is the most complete and detailed intellectual biography of Macaulay that I know of, an impressive feat given Macaulay's voluminous output.The aims of the book are twofold: first, to provide a narrative biography following Macaulay's life and the development of her works as they unfolded across her life, and second, to offer an overview and exposition of her ideas in their social and political context (4). These aims are important to bear in mind, since they establish what the book [End Page 158] is able to do and what it stops short of giving us. The volume is organized chronologically, divided into seven main chapters, each representing a short period in Macaulay's life, with an introduction and concluding chapter that considers her legacy, bringing the total chapters to nine. In each of the substantive chapters, Green mixes a biographical account of Macaulay's life with an often detailed analysis of one or more of her main works written during that period, as well as an assessment of how these works both engaged with, and were received within, some of the political and intellectual debates at the time. This is expertly done, with Green drawing on her intimate acquaintance with Macaulay's correspondence with many of the key figures of the period. The book, therefore, would make an excellent companion to anyone reading through the Correspondence as well as for those studying any of Macaulay's historical volumes, treatises, and tracts.An especially strong aspect of Green's book is the way she weaves an ongoing dialogue between Macaulay and several influential figures from her intellectual world across the chapters. One of these is David Hume, who, like Macaulay, had written an ideologically situated—even if both authors claimed impartiality—multivolume History of England. Though Hume's series was completed before Macaulay's had begun, hers can be seen as a philosophical and political rival to his. While the two would only correspond directly once on the subject, Green compares the impact that their respective philosophies have on their resulting political positions. In the 1760s, Green argues, Hume's naturalism, empiricism, and skepticism gave rise to a social conservative politics, whereas Macaulay's theological rationalism provided the basis for her optimistic and radical politics (50). By the 1790s, however, when Macaulay was writing her Letters on Education, Green detects some elements of a Humean philosophy of mind coming to influence Macaulay, albeit likely through David Hartley, particularly concerning the importance of sympathy on our moral psychology, even if there remain important differences between them (180–82). Green also analyzes Macaulay's engagement with Thomas Hobbes in her Loose Remarks and her two formal Observations on writings by Edmund Burke. Of particular value to historians of republicanism is Green's tracing and examination of Macaulay's ongoing intellectual relationship with key political figures, such as John Wilkes in Britain; Benjamin Franklin, Benjamin Rush, John and Abigail Adams, James Otis, Mercy Otis Warren, and George Washington in America; Anne-Robert Jacques Turgot and Jacques-Pierre Brissot de Warville in France, among many others. Though Macaulay's reputation as an influential political writer... (shrink)

An overview of the latest interdisciplinary research on human morality, capturing moral sensibility as a sophisticated integration of cognitive, emotional, and motivational mechanisms. Over the past decade, an explosion of empirical research in a variety of fields has allowed us to understand human moral sensibility as a sophisticated integration of cognitive, emotional, and motivational mechanisms shaped through evolution, development, and culture. Evolutionary biologists have shown that moral cognition evolved to aid cooperation; developmental psychologists have demonstrated that the elements that underpin (...) morality are in place much earlier than we thought; and social neuroscientists have begun to map brain circuits implicated in moral decision making. This volume offers an overview of current research on the moral brain, examining the topic from disciplinary perspectives that range from anthropology and neurophilosophy to justice and law. The contributors address the evolution of morality, considering precursors of human morality in other species as well as uniquely human adaptations. They examine motivations for morality, exploring the roles of passion, extreme sacrifice, and cooperation. They go on to consider the development of morality, from infancy to adolescence; findings on neurobiological mechanisms of moral cognition; psychopathic immorality; and the implications for justice and law of a more biological understanding of morality. These new findings may challenge our intuitions about society and justice, but they may also lead to more a humane and flexible legal system. Contributors Scott Atran, Abigail A. Baird, Nicolas Baumard, Sarah Brosnan, Jason M. Cowell, Molly J. Crockett, Ricardo de Oliveira-Souza, Andrew W. Delton, Mark R. Dadds, Jean Decety, Jeremy Ginges, Andrea L. Glenn, Joshua D. Greene, J. Kiley Hamlin, David J. Hawes, Jillian Jordan, Max M. Krasnow, Ayelet Lahat, Jorge Moll, Caroline Moul, Thomas Nadelhoffer, Alexander Peysakhovich, Laurent Prétôt, Jesse Prinz, David G. Rand, Rheanna J. Remmel, Emma Roellke, Regina A. Rini, Joshua Rottman, Mark Sheskin, Thalia Wheatley, Liane Young, Roland Zahn. (shrink)

For much of the twentieth century, philosophy and science went their separate ways. In moral philosophy, fear of the so-called naturalistic fallacy kept moral philosophers from incorporating developments in biology and psychology. Since the 1990s, however, many philosophers have drawn on recent advances in cognitive psychology, brain science, and evolutionary psychology to inform their work. This collaborative trend is especially strong in moral philosophy, and these three volumes bring together some of the most innovative work by both philosophers and psychologists (...) in this emerging interdisciplinary field. The neuroscience of morality is in its infancy, with the first brain imaging studies of moral development undertaken only in 2001. The contributors to volume 3 sample the best work in this very new field, discussing a variety of approaches, including functional imaging, lesion studies, abnormal psychology, and developmental neuroscience. Each chapter includes an essay, comments on the essay by other scholars, and a reply by the author of the original essay. Topics include the neural basis of moral emotions and moral judgments as well as comparisons of normal adult moral judgments with those made by children, adolescents, and people with psychopathy, brain damage, and autism. Contributors to volume 3:_ _Abigail Baird, William Casebeer, Cordelia Fine, Nathan Fox, Uta Frith, Jordan Grafman, Joshua Greene, Catherine Hynes, Fatima Azavedo Ignacio, Richard Joyce, Jerome Kagan, Leonard Katz, Kent Kiehl, Jeanette Kennett, Melanie Killen, Daniel Lapsley, Heidi Maibom, Victoria McGeer, John Mikhail, Jorge Moll, Shaun Nichols, Ricardo de Oliveira-Souza, Adina Roskies, Jana Schaich Borg, Katrina Sifferd, Walter Sinnott-Armstrong, Michael Smith, Mark Timmons, Frederick de Vignemont, Paul Whalen, Roland Zahn. (shrink)

For much of the twentieth century, philosophy and science went their separate ways. In moral philosophy, fear of the so-called naturalistic fallacy kept moral philosophers from incorporating developments in biology and psychology. Since the 1990s, however, many philosophers have drawn on recent advances in cognitive psychology, brain science, and evolutionary psychology to inform their work. This collaborative trend is especially strong in moral philosophy, and these three volumes bring together some of the most innovative work by both philosophers and psychologists (...) in this emerging interdisciplinary field. The neuroscience of morality is in its infancy, with the first brain imaging studies of moral development undertaken only in 2001. The contributors to volume 3 sample the best work in this very new field, discussing a variety of approaches, including functional imaging, lesion studies, abnormal psychology, and developmental neuroscience. Each chapter includes an essay, comments on the essay by other scholars, and a reply by the author of the original essay. Topics include the neural basis of moral emotions and moral judgments as well as comparisons of normal adult moral judgments with those made by children, adolescents, and people with psychopathy, brain damage, and autism. Contributors to Volume 3 Abigail Baird, William Casebeer, Cordelia Fine, Nathan Fox, Uta Frith, Jordan Grafman, Joshua Greene, Catherine Hynes, Fatima Azavedo Ignacio, Richard Joyce, Jerome Kagan, Leonard Katz, Kent Kiehl, Jeanette Kennett, Melanie Killen, Daniel Lapsley, Heidi Maibom, Victoria McGeer, John Mikhail, Jorge Moll, Shaun Nichols, Ricardo de Oliveira-Souza, Adina Roskies, Jana Schaich Borg, Katrina Sifferd, Walter Sinnott-Armstrong, Michael Smith, Mark Timmons, Frederick de Vignemont, Paul Whalen, Roland Zahn. (shrink)

The notion of an object file figures prominently in recent work in philosophy and cognitive science. Object files play a role in theories of singular reference, object individuation, perceptual memory, and the development of cognitive capacities. However, the philosophical literature lacks a detailed, empirically informed theory of object files. In this paper, we articulate and defend the multiple-slots view, which specifies both the format and architecture of object files. We argue that object files represent in a non-iconic, propositional format that (...) incorporates discrete symbols for separate features. Moreover, we argue that features of separate categories are stored in separate memory slots within an object file. We supplement this view with a computational framework that characterizes how information about objects is stored and retrieved. (shrink)

A common reductionist assumption is that macro-scale behaviors can be described "bottom-up" if only sufficient details about lower-scale processes are available. The view that an "ideal" or "fundamental" physics would be sufficient to explain all macro-scale phenomena has been met with criticism from philosophers of biology. Specifically, scholars have pointed to the impossibility of deducing biological explanations from physical ones, and to the irreducible nature of distinctively biological processes such as gene regulation and evolution. This paper takes a step back (...) in asking whether bottom-up modeling is feasible even when modeling simple physical systems across scales. By comparing examples of multi-scale modeling in physics and biology, we argue that the “tyranny of scales” problem presents a challenge to reductive explanations in both physics and biology. The problem refers to the scale-dependency of physical and biological behaviors that forces researchers to combine different models relying on different scale-specific mathematical strategies and boundary conditions. Analyzing the ways in which different models are combined in multi-scale modeling also has implications for the relation between physics and biology. Contrary to the assumption that physical science approaches provide reductive explanations in biology, we exemplify how inputs from physics often reveal the importance of macro-scale models and explanations. We illustrate this through an examination of the role of biomechanics modeling in developmental biology. In such contexts, the relation between models at different scales and from different disciplines is neither reductive nor completely autonomous, but interdependent. (shrink)

We critically survey prominent recent scholarship on the question of whether fiction can be a source of epistemic value for those who engage with it fully and appropriately. Such epistemic value might take the form of knowledge (for ‘cognitivists’) or understanding (for ‘neo-cognitivists’). Both camps may be sorted according to a further distinction between views explaining fiction’s epistemic value either in terms of the author’s engaging in a form of telling, or instead via their showing some state of affairs to (...) obtain, a special case of which is the provision of self-knowledge. Fictional works that show rather than tell often employ thought experiments. The epistemic value of some fictional works is indicated by their enabling of empathy, itself illuminated via the psychological process of experience-taking. Whether a fictional work offers epistemic value by telling or showing, there is, in principle, no bar to its being able to deliver on what it offers, and consumers of fiction who exercise epistemic vigilance may gain either knowledge or some degree of understanding from their engagement with it. (shrink)

Prevention of age-related disorders is increasingly in focus of health policies, and it is hoped that early intervention on processes of deterioration can promote healthier and longer lives. New opportunities to slow down the aging process are emerging with new fields such as personalized nutrition. Data-intensive research has the potential to improve the precision of existing risk factors, e.g., to replace coarse-grained markers such as blood cholesterol with more detailed multivariate biomarkers. In this paper, we follow an attempt to develop (...) a new aging biomarker. The vision among the project consortium, comprising both research and industrial partners, is that the new biomarker will be predictive of a range of age-related conditions, which may be preventable through personalized nutrition. We combine philosophical analysis and ethnographic fieldwork to explore the possibilities and challenges of managing aging through bodily signs that are not straightforwardly linked to symptomatic disease. We document how the improvement of measurement brings about new conceptual challenges of demarcating healthy and unhealthy states. Moreover, we highlight that the reframing of aging as risk has social and ethical implications, as it is generative of normative notions of what constitutes successful aging and good citizenship. (shrink)

Many of the objects that we perceive have an important characteristic: When they move, they change shape. For instance, when you watch a person walk across a room, her body constantly deforms. I suggest that we exercise a type of perceptual constancy in response to changes of this sort, which I call structure constancy. In this paper I offer an account of structure constancy. I introduce the notion of compositional structure, and propose that structure constancy involves perceptually representing an object (...) as retaining its compositional structure over time. I argue that compositional structure is represented in visual phenomenology, and I also assemble empirical evidence in support of the claim that compositional structure is recovered by the visual system. Finally, I draw out consequences of this account. I argue that structure constancy has implications for the predictive capacities of perception, and that the phenomenon places important constraints on viable accounts of both the format and reference frame of visual experience. (shrink)

Philosophical theories of emotions, and to an extent some theories of scientific psychology, represent attempts to capture the essence of emotions basically as they are conceived in common sense psychology. Although there are problems, the success of explanations of our behavior in terms of believes, desires and emotions creates a presumption that, at some level of abstraction, they reflect important elements in our psychological nature. It is incumbent on a theory of emotions to provide an account of two salient facts (...) about emotions as conceived in common sense psychology. As intentional states, emotions have representational and rational properties: emotions represent states of affairs; and they are rationally related to other mental representations, figure in rational explanations of behavior, and are open to rational assessment. Emotions also have a close relationship to a range of non-intentional phenomena: in typical cases, emotions involve physiological changes, usually associated with the activation of the autonomic nervous system, which are proprioceptively experienced; and they often involve behavioral tendencies, as well. (shrink)

Design thinking in general, and optimality modeling in particular, have traditionally been associated with adaptationism—a research agenda that gives pride of place to natural selection in shaping biological characters. Our goal is to evaluate the role of design thinking in non-evolutionary analyses. Specifically, we focus on research into abstract design principles that underpin the functional organization of extant organisms. Drawing on case studies from engineering-inspired approaches in biology we show how optimality analysis, and other design-related methods, play a specific methodological (...) role that is tangential to the study of adaptation. To account for the role of these reasoning strategies in contemporary biology, we therefore suggest a reevaluation of the connection between design thinking and adaptationism. (shrink)

In recent years, the philosophical focus of the modeling literature has shifted from descriptions of general properties of models to an interest in different model functions. It has been argued that the diversity of models and their correspondingly different epistemic goals are important for developing intelligible scientific theories. However, more knowledge is needed on how a combination of different epistemic means can generate and stabilize new entities in science. This paper will draw on Rheinberger’s practice-oriented account of knowledge production. The (...) conceptual repertoire of Rheinberger’s historical epistemology offers important insights for an analysis of the modelling practice. I illustrate this with a case study on network modeling in systems biology where engineering approaches are applied to the study of biological systems. I shall argue that the use of multiple means of representations is an essential part of the dynamic of knowledge generation. It is because of – rather than in spite of – the diversity of constraints of different models that the interlocking use of different epistemic means creates a potential for knowledge production. (shrink)

Many authors have posited an “object file” system, which underlies perceptual selection and tracking of objects. Several have proposed that this system internalizes principles specifying what counts as an object and relies on them during tracking. Here I consider a popular view on which the object file system is tuned to entities that satisfy principles of three-dimensionality, cohesion, and boundedness. I argue that the evidence gathered in support of this view is consistent with a more permissive view on which object (...) files select and track according to well-known perceptual organization criteria. Further evidence supplies positive support for the permissive view. (shrink)

Artificial Intelligence technology presents a multitude of ethical concerns, many of which are being actively considered by organizations ranging from small groups in civil society to large corporations and governments. However, it also presents ethical concerns which are not being actively considered. This paper presents a broad overview of twelve topics in ethics in AI, including function, transparency, evil use, good use, bias, unemployment, socio-economic inequality, moral automation and human de-skilling, robot consciousness and rights, dependency, social-psychological effects, and spiritual effects. (...) Each of these topics will be given a brief discussion, though each deserves much deeper consideration. (shrink)

The “practice turn” in philosophy of science has strengthened the connections between philosophy and scientific practice. Apart from reinvigorating philosophy of science, this also increases the relevance of philosophical research for science, society, and science education. In this paper, we reflect on our extensive experience with teaching mandatory philosophy of science courses to science students from a range of programs at University of Copenhagen. We highlight some of the lessons we have learned in making philosophy of science “fit for teaching” (...) outside of philosophy circles by taking selected cases from the students’ own field as the starting point. We argue for adapting philosophy of science teaching to particular audiences of science students, and discuss the benefits of drawing on research within science education to inform curriculum and course design. This involves reconsidering teaching resources, assumptions about students, intended learning outcomes, and teaching formats. We also argue that to make philosophy of science relevant and engaging to science students, it is important to consider their potential career trajectories. By anticipating future contexts and situations in which methodological, conceptual, and ethical questions could be relevant, philosophy of science can demonstrate its value in the education of science students. (shrink)

An approach is provided to the prediction and explanation of quantity implicata that, unlike the majority of approaches available, does not construe Quantity as requiring speakers to make the strongest claim that their evidence permits. Central to this treatment is an elaboration of the notion of what a conversation requires as appealed to in the Cooperative Principle and the Quantity maxim. What a conversation requires is construed as depending, at any given point, upon the aim of the conversation taking place, (...) the conversational record, which includes such features as common ground and salience relations among objects, and any proffered illocution calling for a reply. In accounting for this third dimension a partial characterization is provided of the speech acts of assertion and interrogation in terms of their role in constraining the progress of the conversation in which they occur. (shrink)

Many have held that when a person visually attends to an object, her visual system deploys a representation that designates the object. Call the referential link between such representations and the objects they designate attentive visual reference. In this article I offer an account of attentive visual reference. I argue that the object representations deployed in visual attention—which I call attentive visual object representations —refer directly, and are akin to indexicals. Then I turn to the issue of how the reference (...) of an AVOR is determined relative to a context. After raising problems for existing accounts, I propose a mechanism of reference determination that is both causal and descriptive: For an AVOR to refer to a particular object, the object must appropriately cause the deployment of the AVOR, and the AVOR must be associated with descriptive information about some of the object's geometrical and mereological properties. (shrink)

Many biologists appeal to the so-called Krogh principle when justifying their choice of experimental organisms. The principle states that “for a large number of problems there will be some animal of choice, or a few such animals, on which it can be most conveniently studied”. Despite its popularity, the principle is often critiqued for implying unwarranted generalizations from optimal models. We argue that the Krogh principle should be interpreted in relation to the historical and scientific contexts in which it has (...) been developed and used. We interpret the Krogh Principle as a heuristic, i.e., as a recommendation to approach biological problems through organisms where a specific trait or physiological mechanism is expected to be most distinctively displayed or most experimentally accessible. We designate these organisms “Krogh organisms.” We clarify the differences between uses of model organisms and non-standard Krogh organisms. Among these is the use of Krogh organisms as “negative models” in biomedical research, where organisms are chosen for their dissimilarity to human physiology. Importantly, the representational scope of Krogh organisms and the generalizability of their characteristics are not fixed or assumed but explored through experimental studies. Research on Krogh organisms is steeped in the comparative method characteristic of zoology and comparative physiology, in which studies of biological variation produce insights into general physiological constraints. Accordingly, we conclude that the Krogh principle exemplifies the advantages of studying biological variation as a strategy to produce generalizable insights. (shrink)

Patient-derived xenografts are currently promoted as new translational models in precision oncology. PDXs are immunodeficient mice with human tumors that are used as surrogate models to represent specific types of cancer. By accounting for the genetic heterogeneity of cancer tumors, PDXs are hoped to provide more clinically relevant results in preclinical research. Further, in the function of so-called “mouse avatars”, PDXs are hoped to allow for patient-specific drug testing in real-time. This paper examines the circulation of knowledge and bodily material (...) across the species boundary of human and personalized mouse model, historically as well as in contemporary practices. PDXs raise interesting questions about the relation between animal model and human patient, and about the capacity of hybrid or interspecies models to close existing translational gaps. We highlight that the translational potential of PDXs not only depends on representational matching of model and target, but also on temporal alignment between model development and practical uses. Aside from the importance of ensuring temporal stability of human tumors in a murine body, the mouse avatar concept rests on the possibility of aligning the temporal horizons of the clinic and the lab. We examine strategies to address temporal challenges, including cryopreservation and biobanking, as well as attempts to speed up translation through modification and use of faster developing organisms. We discuss how featured model virtues change with precision oncology, and contend that temporality is a model feature that deserves more philosophical attention. (shrink)

This chapter contains sections titled: Literature, Fiction, and Truth Literary Cognitivism Thought Experiments Genres Learning by Supposing De se Suppositions.

The claim that " Everyone's doing it" is frequently offered as a reason for engaging in behavior that is widespread but less-than-ideal. This is particularly true in business, where competitors' conduct often forces hard choices on managers. When is the claim " Everyone's doing it" a morally valid reason for following others' lead? This discussion proposes and develops five prima facie conditions to identify when the existence of prevalent but otherwise undesirable behavior provides a moral justification for our engaging in (...) such behavior ourselves. The balance of the discussion focuses on testing these conditions by applying them to aseries of representative cases in business ethics. (shrink)

An individual's health, genetic, or environmental-exposure data, placed in an online repository, creates a valuable shared resource that can accelerate biomedical research and even open opportunities for crowd-sourcing discoveries by members of the public. But these data become “immortalized” in ways that may create lasting risk as well as benefit. Once shared on the Internet, the data are difficult or impossible to redact, and identities may be revealed by a process called data linkage, in which online data sets are matched (...) to each other. Reidentification, the process of associating an individual's name with data that were considered deidentified, poses risks such as insurance or employment discrimination, social stigma, and breach of the promises often made in informed-consent documents. At the same time, re-ID poses risks to researchers and indeed to the future of science, should re-ID end up undermining the trust and participation of potential research participants. The ethical challenges of online data sharing are heightened as so-called big data becomes an increasingly important research tool and driver of new research structures. Big data is shifting research to include large numbers of researchers and institutions as well as large numbers of participants providing diverse types of data, so the participants’ consent relationship is no longer with a person or even a research institution. In addition, consent is further transformed because big data analysis often begins with descriptive inquiry and generation of a hypothesis, and the research questions cannot be clearly defined at the outset and may be unforeseeable over the long term. In this article, we consider how expanded data sharing poses new challenges, illustrated by genomics and the transition to new models of consent. We draw on the experiences of participants in an open data platform—the Personal Genome Project—to allow study participants to contribute their voices to inform ethical consent practices and protocol reviews for big-data research. (shrink)

Until recently, genetics counselors and medical geneticists considered themselves lucky if they could provide parents with predictive information about a small number of severe genetic disorders. Testing and counseling were indicated primarily for conditions of thithis s sort. Out of respect for the autonomy of parental reproductive decision making, the prevailing ethic of genetic counseling stressed nondirectiveness and value neutrality As summarized by Arthur Caplan, the hallmarks of this stance includea willingness to provide testing and counseling to all who voluntarily (...) seek it, the presentation of information concerning findings in a manner that is balanced and comprehensible to patients or clients, the fair and balanced presentation of all options for action if a problem is discovered, a willingness to answer all questions asked by those seeking services, and an obligation to protect privacy and confidentiality at all times regardless of societal needs or benefits. (shrink)

Proponents of the emerging field of P4 medicine argue that computational integration and analysis of patient-specific “big data” will revolutionize our health care systems, in particular primary care-based disease prevention. While many ambitions remain visionary, steps to personalize medicine are already taken via personalized genomics, mobile health technologies and pilot projects. An important aim of P4 medicine is to enable disease prevention among healthy persons through detection of risk factors. In this paper, we examine the current status of P4 medicine (...) in light of historical and current challenges to predictive and preventive medicine, including overdiagnosis and overtreatment. Moreover, we ask whether it is likely that in silico integration of patient-specific data will be able to better deal such challenges and to turn risk predictions into disease-preventive actions in a wider social context. Given the lack of evidence that P4 medicine can tip the balance between benefits and harms in preventive medicine, we raise concerns about the current promotion of P4 medicine as a solution to the current challenges in public health. (shrink)

In articles such as “Speech Acts without Propositions?” (2006), Marina Sbisà advocates a “strong” conception of speech acts as means by which speakers modify their own and others’ deontic statuses, including their rights, obligations, and commitments. On this basis Sbisà challenges an influential approach to speech acts as typically if not universally possessing propositional contents. Sbisà argues that such an approach leads to viewing speech acts as primarily aimed at communicating propositional attitudes rather than carrying out socially and normatively significant (...) action. For this reason she advocates eschewing propositions from speech act theory’s conceptual toolkit; she also proposes a liberalization of the distinction between illocutionary force and semantic content, which are widely thought to be mutually exclusive. In this chapter we examine Sbisà’s reasoning and argue that while it does justify denying propositional attitudes a central role in communication, it does not justify dispensing with propositions or other contents in our theorizing about speech acts. In addition, we endorse Sbisà’s proposal for liberalizing the force/content distinction, and show a variety of ways in which force indicators may also possess semantic content. (shrink)

Recent years have witnessed a revival of scientific, political and philosophical discourse concerning the notion of ecological limits. This article provides a conceptual overview of descriptive ecological limit claims—i.e. claims that there are real, biophysical limits—and reviews work in political and social philosophy in which such claims form the basis of proposals for normative limits. The latter are classified in terms of three broad types of normative theorising: distributive justice, institutional/legal reform, and the good life. Within these three categories, the (...) article reviews normative proposals for limits on both aggregate‐level and individual‐level ecological exploitation. It also considers the relevance of political and ideological facts to the normative analysis of ecological limits, raising methodological questions about how normative theorists should respond to a world facing escalating ecological challenges. (shrink)

In the literature of philosophy and religious ethics, Kierkegaard's Fear and Trembling has, with few exceptions, been read as a work focused on ethical questions concerning the norms governing human conduct. However, ethical readings of this book not only miss important features of the text, they render its argument internally incoherent. These problems disappear when Fear and Trembling is understood primarily as a discussion of Christian soteriology that symbolically uses the Abraham story to develop the classical Pauline -Lutheran doctrine of (...) justification through faith alone. (shrink)

There is a substantial literature in epistemology concerning whether knowledge can be transmitted. So-called generative cases of testimony seem to show that testimony cannot transmit knowledge. This article defends the thesis that knowledge transmission by testimony is possible. Once one thinks more carefully about the model of transmission we are employing, however, the stage is set for two surprising results. Supposed counter-examples to knowledge transmission feature transmission in the relevant sense, and, more surprisingly, it is possible to transmit understanding, even (...) when we are construing understanding as an internalist good. (shrink)

ABSTRACTTwo footnotes added to the version of Catharine Cockburn’s Defence of the Essay Of Human Understanding reprinted in her Works have led to various accusations, including that s...

This chapter contains sections titled: Introduction Speech Acts, Acts of Speech, and Performatives Acts and Their Contents Speech Acts, What is Said, and Speaker Meaning Misfires, Abuses, and How Saying Makes It So Illocutions, Perlocutions, and Implicature Direct and Indirect Speech Acts References Further reading.

At first glance, Germaine de Staël and Immanuel Kant evince strikingly different attitudes to aesthetic judgment. Yet she promoted Kant's aesthetics and philosophy. This paper examines both Staël's early literary works and her later De l'Allemagne in order to tease out the relationship between their aesthetic theories.

In the Realm of Criminal Law, Antony Duff seeks to defend the view that we should criminalize conduct only if it is wrongful. Skeptics of legal moralism argue that this occurs all the time in supposedly overinclusive offenses whose definitions capture not only the kind of conduct that constitutes the target wrong, but also a wider class of conduct that is not wrongful prior to prohibition. An example is statutory rape. Duff, in response, contends that such offenses need not violate (...) the requirements of legal moralism. Having exploitative sex with juveniles is obviously wrong even prior to its legal regulation. But having non-exploitative sex with juveniles is also potentially wrong, inasmuch as it involves a violation of a prohibition that society has decided is justified for instrumental reasons. While Duff’s analysis offers an ingenious explanation for why offenses like statutory rape need not violate the bare minimum requirements of legal moralism, it simultaneously exposes separate, largely unacknowledged, problems of fair labeling and proportionality. By combining in a single offense wrongs that are primarily malum in se with ones that are primarily malum prohibitum—a process referred to as “wrongfulness conflation”—we risk treating unlike wrongs alike, imposing disproportionate punishments, and blurring offense labels. And such problems occur not just in the context of statutory rape, but also with respect to a host of other supposedly overinclusive offenses, including various forms of sexual assault. (shrink)

Journal of Political Philosophy, EarlyView.