The historical background of the discovery of adverse health effects of medicines, food additives, pesticides, and other chemicals is reviewed, and the development of national and international regulations and testing procedures to protect the public against the toxic effects of these drugs and chemicals is outlined. Ethical considerations of the safety evaluation of drugs and chemicals by human experimentation and animal toxicity studies, ethical problems associated with clinical trials, with the falsification of clinical and toxicological data, and with inadequate experimental (...) methodology, are reviewed, and the ethics of the marketing of drugs and their post-marketing surveillance, are similarly considered. These ethical problems are illustrated with many specific examples, including the drugs neoarsphenamine, chloramphenicol, thalidomide, diethyl stilboestrol and benoxaprofen. (shrink)

The historical background of the discovery of adverse health effects of medicines, food additives, pesticides, and other chemicals is reviewed, and the development of national and international regulations and testing procedures to protect the public against the toxic effects of these drugs and chemicals is outlined. Ethical considerations of the safety evaluation of drugs and chemicals by human experimentation and animal toxicity studies, ethical problems associated with clinical trials, with the falsification of clinical and toxicological data, and with inadequate experimental (...) methodology, are reviewed, and the ethics of the marketing of drugs and their post-marketing surveillance, are similarly considered. These ethical problems are illustrated with many specific examples, including the drugs neoarsphenamine, chloramphenicol, thalidomide, diethyl stilboestrol and benoxaprofen. (shrink)

The practice of medicine frequently involves the unconsented restriction of liberty. The reasons for unilateral liberty restrictions are typically that being confined, strapped down, or sedated are necessary to prevent the person from harming themselves or others. In this paper, we target the ethics of chemical restraints, which are medications that are used to intentionally restrict the mental states associated with the unwanted behaviors, and are typically not specifically indicated for the condition for which the patient is being (...) treated. Specifically, we aim to identify the conditions under which chemical restraints are ethically permissible. It is wrong to assume that what is morally true of physical restraints is also true of chemical restraints. Our aim is thus to identify the conditions under which chemical restraints are permissible while distinguishing these conditions from those of the application of physical restraints. (shrink)

There are some who would question the need to republish papers that have already appeared elsewhere. Walter Pauel once said that scholars should think in terms of books rather than research papers since the latter become lost in the literature. When he told me this year ago I was not entirely convinced. Surely the young scholar must publish papers to secure his academic position. In addition, throughout his career he attends conferences many of which will require the publication of his (...) papers in the resultant conference volumes. By their very nature such papers often discuss topics in greater detail than that scholar's subsequent books. In this case also the papers tend to become "lost" even when there exit extensive guides to the literature such as the Critical Bibliography published annually in Isis for historians of science. Many of my own papers over the past forty-five years have indeed appeared in such conference volumes as in journals. (shrink)

Medical expertise plays a major role in large-scale welfare arrangements, for example, in private insurance companies. It symbolizes the objectivity and reliability of the procedures of risk selection and legitimates the acceptance and rejection of clients. To understand "reliability" in this context, this article discusses the introduction of chemical urine analysis for life insurance examination between 1880 and 1920. The article argues that reliability of urine analysis is not an intrinsic characteristic of the technology and thus cannot serve as (...) the explanation for the relevance of this technology as a means of risk selection. The construction of a "reliable technology" went hand in hand with the development of a standardized, uniform, and predictable performance of the test and an emergence of specific network—namely, a large-scale, bureaucratic insurance practice in which examination rooms of physicians became connected to the head offices of insurance companies by administrative means. During this process, the balance of power between medical examiners and insurance companies was reversed. Insurance compa nies depended on medicine for risk selection, but physicians increasingly had to act according to the rules set by life insurance companies. (shrink)

This article begins with three problems of “dual loyalties” in medicine, the supposed fact that military physicians are, as medical officers, sometimes required to do what violates ordinary medical ethics—for example, ignore medical need in order to treat their own wounded before civilians or wounded enemy, help make chemical or biological weapons more deadly, or assist at a rough interrogation. These problems are analyzed as special cases of a problem that could arise in any profession, a problem easily (...) resolved using a theory of professional ethics absent from medical ethics until now though common outside. Employing a physician—rather than an ordinary officer, some other kind of healer, or scientist—is to enter a sort of “Ulysses contract” requiring the physician’s professional standards to preempt obligations otherwise applying to an employee. In this way, the article also illustrates the benefits that might accrue to medical ethics from drawing on other fields of practical ethics. (shrink)

A world awash in little understood chemicals tragically harms adults and children alike. Laws keep health agencies in the dark about toxicants, slow, well motivated research hampers protections, and strenuous vested opposition exacerbates the harm. How science is used in the tort law can facilitate or frustrate redress of harm. This book recommends better approaches.

The landscape of seventeenth-century chemistry is complex, and it is impossible to find in it either a clear-cut distinction between alchemy and chemistry or a sort of simple identification of the two. The seventeenth-century cultural context contained a rich variety of "chemical" discourses with arguments ranging from specific experiments to the justification of the validity of chemistry and its novelty in terms of its extraordinary antiquity. On the basis of an analysis of the works by O. Borch, J.J. Glauber, (...) and J. J. Becher, this paper tries to demonstrate that a historical reconstruction of "chemistry" must consider these different levels of the chemical debate. Only then will it be possible to appreciate the outstanding role played by G.E. Stahl in founding modern chemistry. The paper argues in favor of a contextualization of the historical research on seventeenth-century chemistry. (shrink)

Summary James Watt (1736–1819) is best known as an engineer who dramatically improved the efficiency of the steam engine. What we take to be his chemical interests are conventionally seen as peripheral to his main line of work. He is usually treated as a chemist in three main contexts: his ‘practical’ chemical work relating to chlorine bleaching, varnishes, pottery, and so on; his work with Thomas Beddoes on the medicinal uses of various ‘airs’; his, much disputed, claim as (...) a chemical discoverer in the case of the composition of water. In this paper, I argue that Watt himself, and his contemporaries, saw the centrepiece of his steam engine work—the separate condenser—as a chemical invention. I also suggest more broadly that Watt understood the steam engine as a chemical device. For Watt and his Scottish friends, the study of steam and heat was a chemical enquiry. The subsequent changes in the place of heat in chemical enquiry in the early nineteenth century led to a reclassification of Watt's chemical investigations as ‘physics’. This, in turn, produced the sharp separation of his chemical and engineering activities characteristic of modern historiography. Watt's steam engine, which is usually placed in the lineage of machines understood as heat engines, and explained by the laws of thermodynamics, is better seen in context as a chemical device. Watt's ‘indicator diagram’ is reassessed in the light of this. (shrink)

The ArgumentThe status of the person is analyzed as represented by the life sciences under the influence of modern physico–chemical and molecular biology.At the same time the linguistic structure of reality as seen through formalized scientific discourse is not that of a language, but rather that of operational symbolisms, so that the judeo–Greek tradition of Verb as creating and Logos as procreating — which is probably at the origin of the surprising confidence in the possibility of dominating nature through (...) words and formulae — could be suc–cessful only through the depersonalization of language.Notwithstanding appearances, the phenomena of structural and functional self–organization do not really change this situation.In this context the question of the status of the person and of the intentional subject has to be dealt with pragmatically, giving up the notion of a unified scientific theory that would take into consideration at the same time the experi–mental sciences and the human sciences as linking subjectivity and intentionality. (shrink)

First responders to chemical, biological, radiological, or nuclear (CBRN) events face decisions having significant human consequences. Some operational decisions are supported by standard operating procedures, yet these may not suffice for ethical decisions. Responders will be forced to weigh their options, factoring-in contextual peculiarities; they will require guidance on how they can approach novel (indeed unique) ethical problems: they need strategies for “on the spot” ethical decision making. The primary aim of this paper is to examine how first responders (...) should approach on the spot ethical decision-making amid the stress and uncertainty of a CBRN event. Drawing on the long-term professional CBRN experience of one of the authors, this paper sets out a series of practical ethical dilemmas potentially arising in the context of a large-scale chemical incident. We propose a broadly consequentialist approach to on the spot ethical decision-making, but one which incorporates ethical values and rights as “side-constraints”. (shrink)

Starting from the conceptual premises of Garrod, who as long ago as 1902 spoke of chemical individuality, and of Burnet (1949), who recognized as self one's own molecular antigenic structures (as opposed to the antigenic alien: the non- self), the discovery and understanding of HLA antigens and of their extraordinarily individual and differentiated polymorphisms have gained universal recognition. Transplant medicine has now dramatically stressed, within man's knowledge of himself, the characteristic of his biological uniqueness. Today man, having become (...) aware of being a biological antigenic-molecular individuality which is unique and different from that of all of his fellow men (except for monozygotic twins), can therefore easily consider himself a true biological Ego. (shrink)

Van Helmont's chemistry and medicine played a prominent part in the seventeenth-century opposition to Aristotelian natural philosophy and to Galenic medicine. Helmontian works, which rapidly achieved great notoriety all over Europe, gave rise to the most influential version of the chemical philosophy. Helmontian terms such as Archeus, Gas and Alkahest all became part of the accepted vocabulary of seventeenth-century science and medicine.

This dissertation reassesses the chemical revolution that occurred in eighteenth-century France from the pharmacists' perspective. I use French pharmacy to place the event in historical context, understanding this revolution as constituted by more than simply a change in theory. The consolidation of a new scientific community of chemists, professing an importantly changed science of chemistry, is elucidated by examining the changing relationship between the communities of pharmacists and chemists across the eighteenth century. This entails an understanding of the (...) class='Hi'>chemical revolution that takes into account social and institutional transformations as well as theoretical change, and hence incorporates the reforms brought about during and after the French Revolution. First, I examine the social rise of philosophical chemistry as a scientific pursuit increasingly independent of its practical applications, including pharmacy, and then relate this to the theoretical change brought about by Lavoisier and his oxygenic system of chemistry. Then, I consider the institutional reforms that placed Lavoisier's chemistry in French higher education. ;During the seventeenth century, chemistry was intimately entwined with pharmacy, and chemical manipulations were primarily intended to enhance the medicinal properties of a substance. An independent philosophical chemistry gained ground during the eighteenth century, and this development culminated in the work of Lavoisier who cast pharmacy out of his chemistry altogether. Fourcroy, one of Lavoisier's disciples, brought the new chemistry to the pharmacists in both his textbooks and his legislation. Under Napoleon, Fourcroy instituted a new system of education for pharmacists that placed a premium on formal scientific education. Fourcroy's successors, Vauquelin and Bouillon-Lagrange, taught the new chemistry to the elite pharmacists in the School of Pharmacy in Paris. These pharmacists also developed new analytical techniques that combined the aims of the new chemistry with traditional pharmaceutical extractive practices. The scientific pharmacist was created, who, although a respected member of the community of pharmacists, helped to define the new chemistry precisely by not being a true chemist. (shrink)

The practices of Galenic pharmacy that dominated the Western pharmaceutical tradition throughout the medieval and early modern periods generally eschewed methods of alchemical processing and the use of high heat. A unique 10th-century Arabic pharmaceutical treatise, the Kitab al Tasrif by al-Zahrāwī/Abulcasis, however, discussed thermo-chemical techniques of distillation, calcination, and sublimation at length and would go on to have a major impact on Galenic pharmacy. It included recipes, for example, for two highly important distilled substances – rosewater and Philosophers' (...) Oil – that were copied and revised in Latin texts from the later Middle Ages and early modern Spanish formularies. By the end of the 16th century, these recipes had formed the basis for two new categories of distilled medicines – distilled waters and distilled oils – in Galenic pharmacy. Their inclusion in the Galenic formulary indicates that apothecaries in the Latin West were familiar with and indeed practicing thermo-chemical operations during the medieval and early modern periods. (shrink)

This paper explores how a set of observations on the weight of lead were interpreted and assessed between the 1540s and the 1630s across three different interconnecting disciplines: medicine, mineralogy and chemistry. The epistemic import of these discussions will be demonstrated by showing: 1) the changing role and articulation of experience and quantification in the investigation of metals; and 2) the notions associated with weight in different disciplinary frameworks. In medicine and mineralogy, weight was not considered as a (...) specific subject of inquiry in itself, but as a “sign” indicating other relevant properties of metals. In contrast, the chemistry tradition was increasingly concerned with the specific investigation of weight as a property of matter, as seen in the debates that took place in the “chemical revolution.” In addition, this study will reveal the versatility, polysemy, and parallel purposes of the recourse to experiential knowledge in different contexts, where the same “facts” operate within different disciplines. (shrink)

The ArgumentBoth “early chemistry” and “modern concepts” are imprecise. The earliest references to the materials involved in metallurgy, painting, ceramics, and the like, reveal an awareness that one group of materials were called “salts” because of their similarities. I consider this a chemical “concept.” Seeking another example I claim to have found it in the so-called “mineral acids.” The evidence for the existence of this concept is cumulative during the period just before the emergence of “modern chemistry,” of which (...) it may be considered a cause. That evidence is particularly found in the literature of pharmacy and of medicine, both of which belong to the practical arts. (shrink)

SUMMARYThis article considers how chemical analyses were employed not only to study and describe mineral waters, but also to promote new spas, and to reinforce the scientific authority of experts. Scientists, jointly with bath owners, visitors and local authorities, created a significant spa market by transforming rural spaces into social and economic sites. The paper analyses the role developed by the chemist Antonio Casares in the commodification of mineral water in mid-19th century Spain. His scientific publications and water analyses (...) put a new economic value on some Spanish mineral waters and rural springs. First the paper explores the relationship between geographic factors, regulation, and spa development in 19th century Spain, and considers how scientific work improved the economy of some rural areas. Then the transformation of numerous country springs into spas, and the commodification of baths as places between science and leisure is examined. Finally the location of spas across the borders of medicine and chemistry is shown, together with the complex field operations required to study mineral waters. This paper reveals an intense circulation of knowledge between the field, laboratories and scientific publications, as well as the essential role developed by experts like Casares, who not only contributed to the study of rural springs but also to their economic transformation. (shrink)

For years, legal scholars and environmental activists have maintained that traditional tort proof requirements create insurmountable obstacles to recovery for most plaintiffs in chemical exposure cases, be they pharmaceutical suits or environmental toxic tort cases. Generally, tort law requires a plaintiff to show that the defendant owed a duty, that the defendant breached that duty, and that the breach of that duty caused the injury that is the subject of the suit. In some cases those requirements can be relaxed, (...) as for example, when an injury is of a type that does not occur except as a result of negligence. (shrink)

ZusammenfassungDer Einsatz von Psychopharmaka im Altenpflegeheim unterliegt aufgrund institutioneller und struktureller Besonderheiten dieses Versorgungsbereiches, aber auch aufgrund der großen Abhängigkeit und Vulnerabilität eines großen Teils der Altenpflegeheimbewohner in besonderer Weise der Gefahr, in inadäquater und missbräuchlicher Weise durchgeführt zu werden. Die Beachtung der ethischen Grundprinzipien des Wohltuns und des Nichtschadendürfens sowie des Respekts vor der Autonomie der Bewohner (bzw. der Patienten) sollte für alle an der Versorgung unmittelbar und mittelbar Beteiligten handlungsleitend sein. Zum Schutz der Heimbewohner, aber auch mit dem (...) Ziel die Versorgungsqualität in diesem Bereich nachprüfbar zu verbessern, werden in diesem Beitrag Kriterien zur Definition einer inadäquaten bzw. adäquaten Anwendung von Psychopharmaka explizit formuliert, sowie deren Implementierung in prozessorientierte Handlungsalgorithmen und Behandlungsleitlinien vorgeschlagen. Darüber hinaus sollen die Möglichkeiten und Grenzen nicht-pharmakologischer, psychologischer Interventionen als Alternative zur Psychopharmakamedikation diskutiert und hinsichtlich ihrer ethischen Implikationen reflektiert werden. (shrink)

Since the publication of Kuhn’s The Structure of Scientific Revolutions in 1962, the notion of paradigms has shaped the way that philosophy views scientific discovery and how changes in what is regarded as empirical fact occur. This drew heavily on examples from the history of the natural sciences to support Kuhn’s hypothesis. However, some argue that medicine is different from the natural sciences. Gillies has proposed another theory of how paradigms apply to medicine; that of composite paradigms. In (...) doing so, Gillies uses the example of Helicobacter pylori and the shift from the excess-acid theory to the current bacterial-infection theory of gastric ulcers to illustrate these fundamental differences between medicine and the natural sciences.Upon analysis of Gillies’ claim, it is evident that traditional Kuhnian paradigms are also composite and that the manner in which Gillies proposes disease is classified is insufficient in describing medicine. Furthermore, new local paradigms are demonstrably introduced and the change was accompanied by many of the markers of paradigmatic change including changes in worldview, resistance, incommensurability and the introduction of new questions that could not have existed under the previous paradigm. Whilst this change may not be on the scale of the Chemical revolution, it can still be considered paradigm shift.Thagard also proposes an alternate view of discovery using the case of H. pylori. This has much in common with Kuhnian paradigms but Thagard’s theory offers further elucidation and refinement. This allows it to better characterise all of the associated features of discovery relevant in the case of H. pylori, thus provides a preferable tool for examination of this important recent discovery. (shrink)

This edited volume provides a biosemiotic analysis of the ecological relationship between food and medicine. Drawing on the origins of semiotics in medicine, this collection proposes innovative ways of considering aliments and treatments. Considering the ever-evolving character of our understanding of meaning-making in biology, and considering the keen popular interest in issues relating to food and medicines - fueled by an increasing body of interdisciplinary knowledge - the contributions here provide diverse insights and arguments into the larger ecology (...) of organisms’ engagement with and transformation through taking in matter. Bodies interpret molecules, enzymes, and alkaloids they intentionally and unintentionally come in contact with according to their pre-existing receptors. But their receptors are also changed by the experience. Once the body has identified a particular substance, it responds by initiating semiotic sequences and negotiations that fulfill vital functions for the organism at macro-, meso-, and micro-scales. -/- Human abilities to distill and extract the living world into highly refined foods and medicines, however, have created substances far more potent than their counterparts in our historical evolution. Many of these substances also lack certain accompanying proteins, enzymes, and alkaloids that otherwise aid digestion or protect against side-effects in active extracted chemicals. Human biology has yet to catch up with human inventions such as supernormal foods and medicines that may flood receptors, overwhelming the body’s normal satiation mechanisms. This volume discusses how biosemioticians can come to terms with these networks of meaning, providing a valuable and provocative compendium for semioticians, medical researchers and practitioners, sociologists, cultural theorists, bioethicists and scholars investigating the interdisciplinary questions stemming from food and medicine. (shrink)

The development of chemical warfare by the United States in World War I reveals the chaotic nature of American science in the period, and how attempts to overcome problems helped to establish the modern relationship of military-scientific research.

In 2008, Susan L. Smith published “Mustard Gas and American Race-Based Human Experimentation in World War II.” Research, undertaken by the US Army, attempted to quantify the effect of mustard gas and othe chemical agents on people from different racial groups. This was based on the idea that different races would respond differently to the toxins, and in particular that this would be evident through dermal reaction. In other words, different skin color might mean different skin constitution. Some of (...) the testing seemed reasonable, since new chemicals and equipment had been developed since 1919, and the racial issue added another dimension to the research. On closer examination, the testing was primarily based on old chemical agents such as mustard gas, Lewisite and phosgene, and thus the extent of the testing seemed scientifically and medically unnecessary. The chemical agents had been developed, tested, used in battle, the wounded treated and the dead subjected to detailed pathological study. The major combatants in World War I had all committed extensive scientific resources to the study of these agents looking at both offensive and defensive aspects of their use, including toxicity testing. The U.S. Chemical Warfare Service had been formed in 1918 to specifically deal with issues such as toxicity tests, so why was the U.S. Army revisiting the subject of chemical weapons testing during World War II? (shrink)

This essay addresses mineral water as a medical, experimental and economic material. It focuses on the career of the Reverend Dr William Laing , a physician and cleric who wrote two pamphlets about the water of provincial spa located in Peterhead, a town on the north-east coast of Scotland. I begin by outlining his education and I then reconstruct the medical theory that guided his efforts to identify tonics in the well’s water. Next, I explain why Laing and several other (...) local inhabitants thought themselves to be authorities on the palliative power of the water and I close by showing how such effects were commodified by local entrepreneurs. Although I concentrate primarily upon Peterhead Spa, this study touches upon several issues relevant to the types of medical theory and chemical experimentation that were being used in provincial Scotland during the late eighteenth and early nineteenth centuries. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:A Philosophical Path for Paracelsian Medicine: The Ideas, Intellectual Context, and Influence of Petrus Severinus (1540–1602)Dane T. DanielJole Shackelford. A Philosophical Path for Paracelsian Medicine: The Ideas, Intellectual Context, and Influence of Petrus Severinus (1540–1602). Copenhagen: Museum Tusculanum Press, 2004. Pp. 519. Cloth, $83.00.The Paracelsian and Danish royal physician Petrus Severinus complained, "If we can make more potent [drugs], extracted from metals and minerals,... I ask, (...) what age except this one will oppose our efforts?" (115). Indeed, early modern attempts to prepare and prescribe drugs forged in the alchemical laboratory often faced vehement opposition by the university-trained physicians who were weaned on the humoral theory and herbal materia medica of Galen. The orthodox Galenists disdained not only the "chemical poisons" of the Paracelsians, but also their theoretical speculations. After all, the Paracelsians dismissed the belief that disease was the result of humoral imbalances, and promoted both the analogy of microcosm (the human) and macrocosm (the natural world, including the stars), and the idea that diseases were essences or actual beings.Severinus was prescient in his prediction that chemical medicine would become popular, but—as Jole Shackelford notes in the introduction to his A Philosophical Path for Paracelsian Medicine—the concepts of Paracelsus and his followers continue to remain peripheral to the grand narratives of early modern intellectual history. This remains the case despite the illuminating studies of such scholars as the late-Enlightenment medical historian Kurt Polycarp Sprengel, Walter Pagel, and Allen Debus. Thus, Shackelford sheds much needed light on this significant strand of sixteenth- and seventeenth-century science and medicine. Via text-oriented study, particularly of Severinus's Idea medicinæ philosophicæ (Ideal of Philosophical Medicine), Shackelford provides a long-awaited and meticulous biographical account of Severinus and explains with refreshing clarity the sources and speculative theory behind his brand of chemical medicine. Like such recent scholars as Michael Walton and Charles Gunnoe, Shackelford presents Paracelsianism as an ideology, duly noting that the ideas of Severinus, reflecting the reception of Paracelsus in general, were frequently accepted or rejected on religious grounds.To begin, Shackelford establishes Severinus's importance, noting that the medical author and Wittenberg professor Daniel Sennert wrote in 1619 that most iatrochemists followed in the steps of Severinus, who had molded Paracelsus's ideas into a coherent philosophy. Shackelford then traces the story of how Severinus—after studying at such universities as Padua and Paris—joined his friend Pratensis (a recognized Paracelsian) and Tycho [End Page 488] Brahe in bringing an increasingly eclectic Denmark up to continental cultural and intellectual standards. Unfortunately, Severinus's appointment as physician to the king distracted him from completing most of his research projects, but he had already left for posterity his Idea medicinæ, published in 1571.As Shackelford writes, the Idea medicinæ promoted Severinus's belief that Paracelsian medicine was not only an alternative to humoral medicine, but also promised to cope better with "new" fevers. Also, Severinus invested Paracelsianism with authority by emphasizing its ancient forebears and by arguing that Paracelsus was the latest in the line of prisca theologia—one of the few to "ascend to the inner chambers of the Mosaic mysteries" (57). In his amalgamation of Neoplatonism, the Hippocratic tradition, and Paracelsus, Severinus's featured doctrine was efficient causation, or "semina theory." Unlike Robert Boyle's inertial, material corpuscles and their active principles, Severinus's semina were "intrinsically formal and immaterial, and were logically and ontologically prior to matter" (17). The characteristics of these "loci," which accounted for all change in the subvisible world, could be observed through chemical analysis, and they were uniquely attractive to Christians, who were drawn to Severinus's Paracelsian interpretation of Genesis and his idea that when the predestinations contained in the semina are completed, the world will reach its end.Shackelford engages the reader with such fascinating topics as why Tycho—who was not just an astronomer, but also a student of alchemy—departed Denmark, and how Paracelsians were involved in the effort to improve the Danish Bible by "cleansing" it of non-Lutheran elements. Very welcome too is Shackelford's discussion of the neglected topic of Paracelsian therapeutics, especially his evaluation of... (shrink)

SummaryThis paper analyses the development of three methods for detecting bloodstains during the first half of the nineteenth-century in France. After dealing with the main problems in detecting bloodstains, the paper describes the chemical tests introduced in the mid-1820s. Then the first uses of the microscope in the detection of bloodstains around 1827 are discussed. The most controversial method is then examined, the smell test introduced by Jean-Pierre Barruel in 1829, and the debates which took place in French academies (...) and learned societies during ensuing years are surveyed. Moving to the courtrooms a review is conducted of how the different methods were employed in criminal trials. By reviewing these cases, the main arguments against Barruel's test during the 1830s are explored as well as the changes making possible the return of the microscope to legal medicine around 1840. By reconstructing the history of these three methods, the paper reveals how the senses of smell and vision were employed in order to produce convincing evidence in both academies and courts. The paper questions two linear master narratives that are organized in terms of progress and decline: the development of forensic science as a result of continued technological progress; and the supposed decline of smell in the history of the senses, particularly in the realm of chemistry and medicine. (shrink)

Medication reconciliation for pediatric oncology patientparticipants enrolled in clinical trials often reveals the use of chemical complementary medicine alongside protocol therapeutic agents. Considering the blurry delineation between clinical ethics and research ethics, this paper demonstrates how complementary medicine-related protocol violations introduce ethical questions of who should be included and excluded from clinical trials and offers recommendations on how to manage physician-patient-family interactions around these challenging issues.

After the events of 11 September 2001 and the anthrax letters, terrorism and bioterrorism have become the number one issue and motivation for all sorts of discussions and actions within the USA and in the rest of the world. Therefore, it is no wonder that bioterrorism and the threat of chemical weapons are prevalent issues in bioethical debates throughout the world and especially in the USA.In the Wake of Terror tries to give an American perspective on the most important (...) bioethical issues connected with terrorism and bioterrorism. The book is from the series Basic Bioethics published by the MIT press. The series editors …. (shrink)

Although the University of Leeds has attained something of a reputation for the quality of its scholarship in the history of science, few historians are aware of the impressive collection of early scientific and medical books and manuscripts to be found in the University libraries. In order to make the library resources more widely known, we embarked on a systematic survey of the contents of the main historical collections. We wanted not only to give a general impression of the particular (...) strengths and distinctive features of each collection, but also to mention the interesting or rare copies of individual works to be found in them. We have, therefore, examined every book related to the history of science and medicine in the relevant collections, and in doing so we have uncovered a number of important items. For example, we have identified a book which was once in Newton's library, and a previously unrecorded copy of Joseph Black's chemical lectures. More generally, we had not suspected the true size and range of the Chaston Chapman Collection, which makes it a valuable resource for the history of alchemy and early chemistry; nor were we initially aware of the strength of the Historical Collection of the Medical and Dental Library. The wealth of the legacies to the Brotherton and Special Collections also impressed us. (shrink)

As Dobzhansky wrote, nothing in biology makes sense outside the context of the evolutionary theory, and this truth has not been sufficiently explored yet by medicine. We comment on Shanks and Pyles' recently published paper, Evolution and medicine: the long reach of "Dr. Darwin", and discuss some recent advancements in the application of evolutionary theory to carcinogenesis. However, we disagree with Shanks and Pyles about the usefulness of animal experiments in predicting human hazards. Based on the darwinian observation (...) of inter-species and inter-individual variation in all biological functions, Shanks and Pyles suggest that animal experiments cannot be used to identify hazards to human health. We claim that while the activity of enzymes may vary among individuals and among species, this does not indicate that critical events in disease processes occurring after exposure to hazardous agents differ qualitatively between animal models and humans. In addition, the goal is to avoid human disease whenever possible and with the means that are available at a given point in time. Epidemics of cancer could have been prevented if experimental data had been used to reduce human exposures or ban carcinogenic chemicals. We discuss examples. (shrink)