Kant wrote two versions of the Transcendental Deduction, the first, “A-”Deduction in 1781, and the second, “B-”Deduction in 1787. Since Henrich's “The Proof Structure of Kant's Transcendental Deduction”, most work on the Transcendental Deduction attempts to make sense of the B-Deduction's two-step argument structure. Though the A-Deduction has suffered comparative neglect, it has received some attention from interpreters who take its extended treatment of the “subjective” side of cognition to amount to a brand of proto-functionalism. Whatever the merits and demerits (...) of these proto-functionalist approaches, they tend to deemphasize the two arguments that constitute the “objective” side of the A-Deduction, the “argument from above” and then the “argument from below”. Since Kant himself refers to this objective side of the A-Deduction as the “Deduction of the Pure Concepts of the Understanding”, it is surprising that the structure of these arguments has not received closer scrutiny. This is doubly true since Kant actually claims that his revisions for the 1787 version of the Deduction impacted only the “presentation” of it. Any lessons learned from the central arguments of the A-Deduction should help clarify the structure of its younger and more closely studied brother. (shrink)

I consider Kant’s theory of matter, examine his distinction between “formal” and “material” purposiveness, review the related secondary literature, and interpret the role of the stuff of which organs consist in his conception of the special characteristics of organisms. As organisms ingest or absorb compounds, they induce chemical changes among those materials to grow and repair organs. Those organs have their functions with respect to each other in part on account of the materials of which they are composed. A Kantian (...) biological law, I argue, is a coordinated system of lower-order chemical and mechanical regularities that an organism instantiates in the relations that its organs have to each other. I interpret Kant’s contention that organisms resist cognition as claiming that a “discursive understanding” can have no conception of why a particular biological law instantiates whichever lower-order mechanical and chemical regularities it does. (shrink)

In §66 of the Critique of the Teleological Power of Judgment, Kant presents a maxim for judging organisms. The maxim is a hybrid of empirical and a priori elements: Kant claims that though it is derived from experience, it asserts universality and necessity. The author substantiates the maxim and account for its hybrid nature by reconstructing Kant’s view, anchoring it in the text of and philosophical positions from neighboring sections of the Analytic. The reconstruction exposes a proper role for reflective (...) judgment, and for a relation between reason and the faculty of understanding; it shows how Kant’s conception of organisms and species concepts, his general conception of matter, and the systematicity of his conceptual hierarchy are fundamental to justifying the maxim. (shrink)

Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face transplantation must meet all the ethical requirements (...) usually applied to health care research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and transplantation. Finally, we maintain that the time has come to move facial transplantation research into the clinical phase. (shrink)

In the Critique of the Teleological Power of Judgment Kant argues that organisms have inner purposiveness. He introduces inner purposiveness in contrast to relative purposiveness. I examine Kant’s discussion of relative purposiveness in §63. I then argue that Kant establishes three theses in §63 that he subsequently modifies in §64 and further refines in §65. In my view, his discussion of relative purposiveness serves a broader purpose than just to present a contrast from which to consider inner purposiveness. The discussion (...) of relative purposiveness establishes a framework for a sustained thread of argument from §63 through §65, culminating in Kant’s often discussed claim that we must judge organisms to be natural ends. My interpretation exposes a more significant argumentative role for relative purposiveness than is typically recognized. (shrink)

In the Critique of the Teleological Power of Judgment Kant argues that organisms have inner purposiveness. He introduces inner purposiveness in contrast to relative purposiveness. I examine Kant’s discussion of relative purposiveness in §63. I then argue that Kant establishes three theses in §63 that he subsequently modifies in §64 and further refines in §65. In my view, his discussion of relative purposiveness serves a broader purpose than just to present a contrast from which to consider inner purposiveness. The discussion (...) of relative purposiveness establishes a framework for a sustained thread of argument from §63 through §65, culminating in Kant’s often discussed claim that we must judge organisms to be natural ends. My interpretation exposes a more significant argumentative role for relative purposiveness than is typically recognized. (shrink)

Physics has been thought to truly represent reality since at least Galileo, and the foundations of physics are always established using philosophical ideas. In particular, the elegant naming of physical entities is usually very influential in the acceptance of physical theories. We here demonstrate (using current developments in thermodynamics as an example) that both the epistemology and the ontology of physics ultimately rest on poetic language. What we understand depends essentially on the language we use. We wish to establish our (...) knowledge securely, but strictly speaking this is impossible using only analytic language. Knowledge of the meanings of things must use a natural language designed to express meaning, that is, poetic language. Although the world is really there, and although we can indeed know it truly, this knowledge is never either complete or certain but ultimately must rest on intuition. Reading a recently discovered artefact with a palaeo-Hebrew inscription as from the first century, we demonstrate from it that this ontological understanding long predates the Hellenic period. Poetic language is primary, both logically and temporally. (shrink)

The Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to enhance accessibility to results of protein (...) research. PRO (http://pir.georgetown.edu/pro) is part of the Open Biomedical Ontologies (OBO) Foundry. (shrink)

Main Response Topics ? Introduction ? Open display and public evaluation ? Publicity versus patient privacy ? Facial tissue donation ? Validity of Louisville Instrument for Risk Acceptance ? Patients' understanding of risk ? Face versus hand transplantation ? Rejection rates/risks ? Patient compliance ? Exit strategy ? Functional recovery ? Societietal implications ? Psychological implications ? Conclusion: Uncertainty likely to persist.

Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala (...) and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p <.025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology. (shrink)

Over the last 2,300 years or so, many philosophers have believed that species are individuated by essences that are at least in part intrinsic. Psychologists tell us most folks also believe this view. But most philosophers of biology have abandoned the view, in light of evolutionary conceptions of species. In defiance, Michael Devitt has attempted in this journal to resurrect a version of the view, which he calls Intrinsic Biological Essentialism. I show that his arguments for the resurrection fail, (...) and I identify challenges that face anyone wishing to defend Intrinsic Biological Essentialism. (shrink)

Barker, Sue Review(s) of: The road to eternal life: Reflections on the prologue of Benedict's rule, by Michael Casey OCSO, (Mulgrave VIC: John Garratt Publishing, 2011), pp.182, $29.95.

In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 39.3 (2005) 44-57 [Access article in PDF] Literary Biography: The Cinderella of Literary Studies Michael Benton There are no prizes for guessing who are the two ugly sisters: Criticism, the elder one, dominated literary studies for the first half of the twentieth century; theory, her younger sister, flounced to the fore in the second half. Meanwhile, 'Cinders,' who had been doing the chores (...) for centuries, has been magically transformed in recent times, decked out in new clothes by Richard Holmes, Claire Tomalin, Juliet Barker, Peter Ackroyd et al., and, as the millennium approached, celebrated and admired on all sides. At the start of the new century, literary biography remains in vogue. The bibliography that carries it forward is rolling, and there is no sign of it turning into a pumpkin. Why is Cinderella so popular?One obvious if superficial answer might be that literary biography is where literary people go who find the contemporary preoccupation with theory to be personally undernourishing and critically unenlightening; they would rather stay with the literary works themselves and with the lives, the minds, and the times that produced them. Yet it is not only literary biography that is thriving; life writing in general is the fastest-growing area of mainstream publishing, evidence for which can be seen in Waterstone's flagship store in London's Piccadilly, which devotes its prime ground-floor site to thousands of biographies. This commercial high profile is responding to an evident, if unfocused, need to look at other lives and understand them. Individual reasons for the popularity of biography range from prurient interest and hero worship to a, perhaps unrecognized, search for coherence and purpose in an age that is often disinclined either to accept institutional values or to respect traditional authority. The motives for this search usually include the desire for recognizable success, to which end the invention of a convincing identity is essential. Biographies offer models of how others live, face challenges, and cope with change; they are prime sites for studying ourselves. Curiously, this justification for biography as providing [End Page 44] a model for living was felt most strongly when this literary genre first emerged in the eighteenth century. The difference today is that the model has changed: Biography as a moral exemplum based upon Christian principles has been replaced in today's celebrity culture by the demand for models of success provided by public personalities. Nonetheless, whatever the range of satisfactions readers seek in biography, life writing offers, in one form or another, detailed pictures of widely different ways of living and amid these, perhaps, some clues to how an individual sense of identity might be shaped.Literary biographies (i.e., biographies of writers, not biographies with a particular literary quality) are a significant and, in some respects, a unique subgenre since they purport to offer access to the creative imagination. They have a long and distinguished history from Johnson and Boswell to the present day; they are sometimes written by other novelists (Elizabeth Gaskell on Charlotte Bronte, Peter Ackroyd on Dickens); and autobiographical writing may take the form of poetry (Wordsworth) or fiction (Joyce).1 Furthermore recent writing in this field has increasingly introduced elements of metabiography in books by Adam Sisman2 and Lucasta Miller.3 It is evident, therefore, that literary biography offers a rich and varied area of study that raises issues about the relationships among biography, history, fiction, and poetry that are fundamental to aesthetic education.Yet despite this promise, it has become a truism to declare that biography has failed to establish any theoretical foundations upon which to build. Backscheider quotes Ira Nadel's remark on the absence of "a sustained theoretical discussion of biography incorporating some of the more probing and original speculations about language, structure, and discourse that have dominated post-structuralist thought."4 She goes on to lament the poverty of criticism; the absence of a cultivated readership; the failure to engage even with the practical questions of selection, organization, or presentation; and indicates that readers of biography are too easily... (shrink)

: To honor Bernard Goldstein, this article highlights in the "Defense of Theon against George of Trebizond" by Regiomontanus (1436-1476) themes that resonate with leading strands of Goldstein's scholarship. I argue that, in this poorly-known work, Regiomontanus's mastery of Ptolemy's mathematical astronomy, his interest in making astronomy physical, and his homocentric ideals stand in unresolved tension. Each of these themes resonates with Gold- stein's fundamental work on the Almagest, the Planetary Hypotheses, and al-Bitruji's Principles of Astronomy. I flesh out these (...) tensions with an intriguing interpretation of the history of astronomy, in which Regiomontanus contrasts the two-dimensional "eccentric astronomy" attributed to the Almagest and the Arabs with the three-dimensional spheres of the "later" astronomers. A similar contrast reappears when Regiomontanus portrays as a "fictitious art" an astronomy that does not go beyond the accommodation of computations to the appearances. To conclude, I use Regiomontanus's expression to reinstate (pace Goldstein and Barker in this journal, 1998) fictionalism as an actor's category in Osiander and sixteenth-century astronomy. (shrink)

One form of argument from analogy is identified and Stephen Barker's remarks about a second kind of argument from analogy, non-inductive (and non-deductive) argument from analogy, are used as a springboard to identify a second form. That form is then refined, explained, exemplified, and related to the first form. It is argued that there is a spectrum of different forms of argument from analogy, with the two forms identified being end points on the spectrum. Except in terms of form, (...) however, there is no reason to speak of two different kinds of argument from analogy. (shrink)

These 17 essays covers all aspects of Bernard Stiegler's work, from poststructuralism, anthropology and psychoanalysis to his work on the politics of memory, 'libidinal economy', technoscience and aesthetics, keeping a focus on his key theory of technics throughout. Stiegler brings together key concepts from Plato, Freud, Derrida and Simondon to argue that the human is 'invented' through technics rather than a product of purely biological evolution. Stiegler is a thinker at the forefront of our contemporary concerns with consumerism, technology, inter-generational (...) division, political apathy and economic crisis. His ambitious project is to go beyond these sources of social distress to uncover and examine precisely 'what makes life worth living'. Contributors include: Stephen Barker, University of California Irvine and translator of Steigler; Richard Beardsworth, American University of Paris and translator of Stiegler; Miguel de Beistegui; University of Warwick; Marc Crepon, Ecole normale superieure and co-founder of Stiegler's think tank, Ars Industrialis and Daniel Ross, co-director of 'The Ister', the award-winning film on Heidegger, and translator of Stiegler. (shrink)

The Politics is one of the most influential texts in the history of political thought, and it raises issues which still confront anyone who wants to think seriously about the ways in which human societies are organized and governed. By examining the way societies are run--from households to city states--Aristotle establishes how successful constitutions can best be initiated and upheld. For this edition, Sir Ernest Barker's fine translation, which has been widely used for nearly half a century, has been (...) extensively revised to meet the needs of the modern reader. The accessible introduction and clear notes examine the historical and philosophical background of the work and discuss its significance for modern political thought. (shrink)

The view that it is better for life to be created free of disability is pervasive in both common sense and philosophy. We cast doubt on this view by focusing on an influential line of thinking that manifests it. That thinking begins with a widely-discussed principle, Procreative Beneficence, and draws conclusions about parental choice and disability. After reconstructing two versions of this argument, we critique the first by exploring the relationship between different understandings of well-being and disability, and the second (...) by more briefly focusing on the idea of a significant reason. By placing these results against the broader historical and ongoing contexts in which the lives of those with disabilities have been deemed of inferior quality, we conclude with a call for greater humility about disability and well-being in thought and practice. (shrink)

Are the sculpture and the mass of gold which permanently makes it up one object or two? In this article, we argue that the monist, who answers ‘one object’, cannot accommodate the asymmetry of material constitution. To say ‘the mass of gold materially constitutes the sculpture, whereas the sculpture does not materially constitute the mass of gold’, the monist must treat ‘materially constitutes’ as an Abelardian predicate, whose denotation is sensitive to the linguistic context in which it appears. We motivate (...) this approach in terms of modal analyses of material constitution, but argue that ultimately it fails. The monist must instead accept a deflationary, symmetrical use of ‘materially constitutes’. We argue that this is a serious cost for her approach. (shrink)

This volume presents new work in history and historiography to the increasingly broad audience for studies of the history and philosophy of science. These essays are linked by a concern to understand the context of early modern science in its own context.

Living things are often plastic during their early development and are moulded by the environment. Many human fetuses have to adapt to a limited supply of nutrients, and in doing so they permanently change their physiology and metabolism. These programmed changes may be the origins of a number of diseases in later life, including coronary heart disease, stroke, diabetes and hypertension.

In this paper I want to examine a view of the Darwinian theory of evolution which was put forward fairly recently by A. R. Manser. His approach is of interest not only in itself, but also because it may be expanded to raise some fundamental questions about the nature of the science of biology in general. I shall not consider these further implications here, but shall concentrate on an examination of his thesis in the context in which it is raised. (...) My paper falls into two sections. In the first I shall state Manser's thesis and some of the arguments with which he supports it, and shall try to show how a series of objections raised by A. G. N. Flew and K. Connolly may be answered. In the second I shall offer on my own account a positive argument to provide a possible basis for his point of view, with the aim of indicating why the theory should be of the kind he suggests, and what form the study of evolution must take. (shrink)

Essentialism is widely regarded as a mistaken view of biological kinds, such as species. After recounting why (sections 2-3), we provide a brief survey of the chief responses to the “death of essentialism” in the philosophy of biology (section 4). We then develop one of these responses, the claim that biological kinds are homeostatic property clusters (sections 5-6) illustrating this view with several novel examples (section 7). Although this view was first expressed 20 years ago, and has received recent discussion (...) and critique, it remains underdeveloped and is often misrepresented by its critics (section 8). (shrink)

We argue that in contemporary business organizations, in which fundamental purpose is construed to be increased value—especially in ‘participative’ organizations, in which non–hierarchal interaction (for example, work teams) is the norm; and in ‘adaptive’ organizations, in which unpredictable change is the rule—a process of values covenanting will be much more valueable than just espoused values or even values covenants. We propose such a process model for organizational values covenanting and argue that such covenanting reflects an anthropomorphism of the human character (...) development process, validated in terms of the theory of viable systems. (shrink)

This paper concerns virtue-based ethical principles that bear upon agricultural uses of technologies, such as GM crops and CRISPR crops. It does three things. First, it argues for a new type of virtue ethics approach to such cases. Typical virtue ethics principles are vague and unspecific. These are sometimes useful, but we show how to supplement them with more specific virtue ethics principles that are useful to people working in specific applied domains, where morally relevant domain-specific conditions recur. We do (...) this while still fulfilling the need for principles and associated practical reasoning to flexibly respect variation between cases. Second, with our more detailed approach we criticize and improve upon a commonly discussed principle about ecosystemic external goods that are crucial for human flourishing. We show this principle is far more conservative than appreciated, as it would prohibit many technology uses that are uncontroversially acceptable. We then replace this principle with two more specific ones. One identifies specific conditions in which ecosystem considerations are against a technology use, the other identifies favorable conditions. Third, we uncover a humility-based principle that operates within an influential “hubris argument” against uses of several biotechnologies in agriculture. These arguments lack a substantive theory of the nature of humility. We clarify such a theory, and then use it to replace the uncovered humility-based principle with our own more specific one that shifts focus from past moral failings, to current epistemic limits when deciding whether to support new technologies. (shrink)

In this paper I outline the PAIR account of joint attention as a perceptual-practical, affectively charged intentional relation. I argue that to explain joint attention we need to leave the received understanding of propositions and propositional attitudes and the picture of content connected to it behind and embrace the notions of subject mode and position mode content. I also explore the relation between joint attention and communication.

Given the increasing need for solid organ and tissue transplants and the decreasing supply of suitable allographic organs and tissue to meet this need, it is understandable that the hope for successful xenotransplantation has resurfaced in recent years. The biomedical obstacles to xenotransplantation encountered in previous attempts could be mitigated or overcome by developments in immunosuppression and especially by genetic manipulation of organ source animals. In this essay we consider the history of xenotransplantation, discuss the biomedical obstacles to success, explore (...) recent developments in transgenic sourcing of organs and tissues, and analyze the problem of infectious disease resulting from xenotransplantation (xenosis). We then apply a model of risk analysis to these risks. The conclusions of this risk analysis are used in an ethical evaluation of informed consent in xenotransplantation, with an ethical foundation in Kantian autonomy and Levinasian heteronomic alterity. Our conclusion is that individual and collective informed consent to the infectious disease risks of xenotransplantation requires an open, participatory and dialogical public policy process not yet seen in the United States and Europe. Until that process is created, we propose caution in xenotransplantation in general and a postponement of solid organ xenotransplants in particular. (shrink)

In this chapter I consider the prospects of globalizing expressivism. Expressivism is a position in the philosophy of language that questions the central role of representation in a theory of meaning or linguistic function. An expressivist about a domain D of discourse proposes that utterances of sentences in D should not be seen, at the level of analysis as representing how things are, but as expression of non-representational states. So, in the domain of value-utterances, the standard idea is that speakers (...) are expressing affective-states, such as approval or disapproval focused on objects or conditions. Global expressivism is the thesis that for all domains of discourse, we treat utterances, at the level of analysis, as expressing non-representational states. I set out several conceptions of how one might formulate this programme. The first involves minimalism about truth and semantic content – and only partially gives up representationalism (viz., the thesis that some utterances express representational states). The second is Price’s conception, which incorporates minimalism, Brandomian inferentalism, and concepts from Carnap, but still clings to representationalism. I then arrive at my favoured third conception, which does not employ minimalism or inferentialism, and eliminates vestiges of representationalism. It does the latter by embracing expressivism about meaning-attribution. Having set out key aspects of the approach I then address the question of metaphysics. What metaphysical conception of reality goes with global expressivism so understood? I argue it implies a form of metametaphysical nihilism. This is that idea that reality lacks any ultimate nature. (shrink)

English ethologist, evolutionary biologist, and writer Richard Dawkins opens Chapter 2 of his bestseller The God Delusion by saying that the God of the Old Testament is "arguably the most unpleasant character in all fiction" and goes on to list nineteen negative character traits. Now in God : the Most Unpleasant Character in All Fiction, Dan Barker, a former ordained minister and current atheist, proves that Dawkins was right."--Jacket.

Tracking theories of knowledge are widely known to have the consequence that knowledge is not closed. Recent arguments by Vogel and Hawthorne claim both that there are no legitimate examples of knowledge without closure and that the costs of theories that deny closure are too great. This paper considers the tracking theories of Dretske and Nozick and the arguments by Vogel and Hawthorne. We reject the arguments of Vogel and Hawthorne and evaluate the costs of closure denial for tracking theories (...) of knowledge. (shrink)

Morals from Motives develops a virtue ethics inspired more by Hume and Hutcheson's moral sentimentalism than by recently-influential Aristotelianism. It argues that a reconfigured and expanded "morality of caring" can offer a general account of right and wrong action as well as social justice. Expanding the frontiers of ethics, it goes on to show how a motive-based "pure" virtue theory can also help us to understand the nature of human well-being and practical reason.