Integrating concepts of maintenance and of origins is essential to explaining biological diversity. The unified theory of evolution attempts to find a common theme linking production rules inherent in biological systems, explaining the origin of biological order as a manifestation of the flow of energy and the flow of information on various spatial and temporal scales, with the recognition that natural selection is an evolutionarily relevant process. Biological systems persist in space and time by transfor ming energy from one state (...) to another in a manner that generates structures which allows the system to continue to persist. Two classes of energetic transformations allow this; heat-generating transformations, resulting in a net loss of energy from the system, and conservative transformations, changing unusable energy into states that can be stored and used subsequently. All conservative transformations in biological systems are coupled with heat-generating transformations; hence, inherent biological production, or genealogical proesses, is positively entropic. There is a self-organizing phenomenology common to genealogical phenomena, which imparts an arrow of time to biological systems. Natural selection, which by itself is time-reversible, contributes to the organization of the self-organized genealogical trajectories. The interplay of genealogical (diversity-promoting) and selective (diversity-limiting) processes produces biological order to which the primary contribution is genealogical history. Dynamic changes occuring on times scales shorter than speciation rates are microevolutionary; those occuring on time scales longer than speciation rates are macroevolutionary. Macroevolutionary processes are neither redicible to, nor autonomous from, microevolutionary processes. (shrink)

This article sketches a theory of time-binding communication, which is to say communication that unifies widely separated times much as space-binding communication unifies widely separated places. Drawing from the work of Harold Innis, it first describes the function and character of time-binding communication as a means to social continuity. Then, following Alasdair MacIntyre and Michael Oakshott, it explains the nature and necessary circumstances of this sort of time-binding communication, or tradition. It discusses the character, consequences, and causes of decadence - (...) radical discontinuity - as these have been described by Richard Weaver, C. E. M. Joad, and Jacques Barzun. Finally, it turns to David Lowenthal's notion of the past as a 'foreign country' in an effort to explain the relations between modernity and both tradition and decadence, as well as the geography of tradition and decadence in the modern world. (shrink)

The modern university is a demoralizing institution, largely devoted to the propagation of nihilism and liberation of desire. The apotheosis of this hungry god of the untrammeled will has taken more than 200 years, but the slow ascent has given humanistic scholarship its basic shape. The ascent of 'reason' over tradition and religion, at the end of the eighteenth century, caused conservative thought to emerge, reluctantly, and frame rational defenses of natural (i.e. spontaneously evolved) social institutions and belief systems. This (...) has always been handicapped by the need to fight rationalism with reason. This same ascent inspired revolutionary theorists to frame their ringing denunciations and inspiring panaceas, most of which proved purely destructive because of the tragic inability of revolutionary practice to produce the promised and indispensable metanoia. Partly due to the limited success of conservative thought and revolutionary theory, untrammeled will has, more recently, ascended over reason, tradition, and religion, to give us the postmodern nihilism of Luciferian scholars. (shrink)

F. H. Bradley has assured us that where all is bad it must be good to know the worst. In the case before us the worst is that Jonathan Edwards, from whatever perspective he is viewed, represents an imposing enigma. I confess at the outset that the enigma is one I am unable entirely to dispel, although I am confident that I can explain what is enigmatic about his thought, his approach, his caste of mind, and that I can (...) do so "not through a glass darkly." The central problem is this: Edwards, on the one hand, accepted totally the tradition established by the Reformers with respect to the absolute primacy and authority of the Bible, and he could approach the biblical writings with that conviction of their inerrancy and literal truth which one usually associates with Protestant fundamentalism. On the other hand, Edwards insisted vigorously on the criteria of reason and experience, and he was without equal on the American scene up to the time of Charles Peirce in his capacity for philosophical analysis, for sustaining a logical argument, and for expressing his conclusions with the most painstaking attention to subtle nuances of meaning and rhetorical effectiveness. Moreover, he insisted on the use of philosophical concepts and principles in considering the "things of religion" and his speculations about creation, his estheticism, and pantheism caused deep anxiety in the minds of traditional Calvinists, whose theology was as literal as their biblical exegesis. This double-barrelled character of his approach has led critics to define him as a reactionary and "medieval" thinker who had lost touch with those currents of thought which would eventually lead to the "modern" point of view. Without pausing to evaluate that charge at this point, one thing at least is clear: in relation to his contemporaries Edwards was alone in his attempt to make the religious tradition intelligible in those philosophical terms first laid down by Augustine and Anselm in their enterprise of "faith seeking understanding.". (shrink)

What determines whether an action is right or wrong? Morality, Rules, and Consequences: A Critical Reader explores for students and researchers the relationship between consequentialist theory and moral rules. Most of the chapters focus on rule consequentialism or on the distinction between act and rule versions of consequentialism. Contributors, among them the leading philosophers in the discipline, suggest ways of assessing whether rule consequentialism could be a satisfactory moral theory. These essays, all of which are previously unpublished, provide students in (...) moral philosophy with essential material and ask key questions on just what the criteria for an adequate moral theory might be. (shrink)

The power of the application of bioinformatics across multiple publicly available transcriptomic data sets was explored. Using 19 human and mouse circadian transcriptomic data sets, we found that NR1D1 and NR1D2 which encode heme‐responsive nuclear receptors are the most rhythmic transcripts across sleep conditions and tissues suggesting that they are at the core of circadian rhythm generation. Analyzes of human transcriptomic data show that a core set of transcripts related to processes including immune function, glucocorticoid signalling, and lipid metabolism is (...) rhythmically expressed independently of the sleep‐wake cycle. We also identify key transcripts associated with transcription and translation that are disrupted by sleep manipulations, and through network analysis identify putative mechanisms underlying the adverse health outcomes associated with sleep disruption, such as diabetes and cancer. Comparative bioinformatics applied to existing and future data sets will be a powerful tool for the identification of core circadian‐ and sleep‐dependent molecules. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Some decades ago in his intriguing book on Jonathan Edwards, Perry Miller used to great effect the device of supposing a two-fold biography of Edwards, an external one consisting of the historical record embracing the major events of his life and times, and an internal one aimed at an interpretation of the mind of Edwards and the development of his thought.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Jonathan Edwards's Philosophy of History: The Reenchantment of the World in the Age of EnlightenmentJohn E. SmithAvihu Zakai. Jonathan Edwards's Philosophy of History: The Reenchantment of the World in the Age of Enlightenment. Princeton: Princeton University Press, 2003. Pp. xvii + 348. Cloth, $49.95.Edwards's History of Redemption is the focus of this study by Avihu Zakai—Professor of History at the Hebrew University in Jerusalem. The History (...) is a series of thirty sermons Edwards preached on Isaiah 51:8 "... my righteousness shall be forever... my salvation from generation to generation." For him, it was a "new method in divinity... thrown into the form of a history"—a narrative showing God's sovereignty in redemption "from the fall of man to the end of the world."Zakai gives a comprehensive account of Edwards's view of history meant to highlight his struggle against modern beliefs threatening Christian faith (308; passim). The discussion is not limited to history, but includes most of Edwards's writing from 1720-1750 with emphasis on his opposition to the Enlightenment. Zakai cannot interpret so many works with the accuracy needed; he repeats old errors such as opposing the "head" and "heart" in the Affections and minimizing Edwards's respect for "common morality" in the ethical writings. Zakai is right in saying that Edwards insisted on God's authority over the world and history, but he puts it in such absolutistic terms that he often seems to abandon historical analysis in favor of exhortation.Zakai's best contribution is in his search for the general framework of God's redemption of the "engine" driving history (120ff.; 213ff.). He finds the answer in "seasons" of revival such as the Great Awakening. This is true, but Edwards notes other special events like the Reformation that "promoted the work of redemption" (Works, 9. 272), but are not revivals in the usual sense. For Edwards, special events are of many kinds and are identified by interpretation based on God's Providence. As Miller claimed, interpretation is essential; without it we may have a chronicle of events, but no history. Zakai seems to underestimate this point and the many problems it poses.The book strikes me as one more attempt—George Marsden's recent book, Jonathan Edwards: A Life (New Haven, 2003), is another—to rescue Edwards from "profane" interpreters like Miller who saw that Edwards learned from the Enlightenment even though he challenged many of its ideas. In my view, Edwards can well take care of himself.John E. SmithYale UniversityCopyright © 2004 Journal of the History of Philosophy, Inc.... (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

This title presents a comprehensive guide to interpretative phenomenological analysis (IPA) which is an increasingly popular approach to qualitative inquiry taught to undergraduate and postgraduate students today.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Jonathan Edwards's Philosophy of History: The Reenchantment of the World in the Age of EnlightenmentJohn E. SmithAvihu Zakai. Jonathan Edwards's Philosophy of History: The Reenchantment of the World in the Age of Enlightenment. Princeton: Princeton University Press, 2003. Pp. xvii + 348. Cloth, $49.95.Edwards's History of Redemption is the focus of this study by Avihu Zakai—Professor of History at the Hebrew University in Jerusalem. The History (...) is a series of thirty sermons Edwards preached on Isaiah 51:8 "... my righteousness shall be forever... my salvation from generation to generation." For him, it was a "new method in divinity... thrown into the form of a history"—a narrative showing God's sovereignty in redemption "from the fall of man to the end of the world."Zakai gives a comprehensive account of Edwards's view of history meant to highlight his struggle against modern beliefs threatening Christian faith (308; passim). The discussion is not limited to history, but includes most of Edwards's writing from 1720-1750 with emphasis on his opposition to the Enlightenment. Zakai cannot interpret so many works with the accuracy needed; he repeats old errors such as opposing the "head" and "heart" in the Affections and minimizing Edwards's respect for "common morality" in the ethical writings. Zakai is right in saying that Edwards insisted on God's authority over the world and history, but he puts it in such absolutistic terms that he often seems to abandon historical analysis in favor of exhortation.Zakai's best contribution is in his search for the general framework of God's redemption of the "engine" driving history (120ff.; 213ff.). He finds the answer in "seasons" of revival such as the Great Awakening. This is true, but Edwards notes other special events like the Reformation that "promoted the work of redemption" (Works, 9. 272), but are not revivals in the usual sense. For Edwards, special events are of many kinds and are identified by interpretation based on God's Providence. As Miller claimed, interpretation is essential; without it we may have a chronicle of events, but no history. Zakai seems to underestimate this point and the many problems it poses.The book strikes me as one more attempt—George Marsden's recent book, Jonathan Edwards: A Life (New Haven, 2003), is another—to rescue Edwards from "profane" interpreters like Miller who saw that Edwards learned from the Enlightenment even though he challenged many of its ideas. In my view, Edwards can well take care of himself.John E. SmithYale UniversityCopyright © 2004 Journal of the History of Philosophy, Inc.... (shrink)

The introduction explain the need for how an international, inclusive discussion about the range of different methodological approaches from different traditions of philosophy can be read alongside each other and be seen in sometimes very critical conversation with each other. In addition, the introduction identifies four broad themes in the volume: the largest group of chapters advocate methods that promote history of philosophy as an unapologetic, autonomous enterprise with its own criteria within philosophy. Second, three chapters can be seen as (...) historicizing the history of philosophy from within. Third, four chapters argue for history of philosophy as a means toward making contributions to contemporary philosophy. Finally, two chapters explore the relationship between the history of philosophy and the history of science. (shrink)

Foreword by Robert H. Bork -- Culture wars -- A distorted understanding of rights -- The right to privacy -- Griswold and contraception -- Roe and abortion -- Assisted suicide and homosexuality -- Political connections and natural consequences.

Introduction: Foundations of faith described -- Christian history : a brief overview -- The Apostolic Age (ca. A.D. 30-100 -- The Patristic Age (ca. A.D. 100-500) -- The Medieval Age (ca. A.D. 500-1500) -- The Reformation/counter-Reformation Age -- The Modern Age (ca. A.D. 1600-1950) -- The Postmodern Age (ca. A.D. 1950-present) -- Mormon and evangelical theology : a comparison -- Scripture and revelation -- God and humanity -- Church and temple -- Salvation and the afterlife -- Moral and social standards (...) -- Mormonism and Christianity -- Sociological foundations of faith -- Question 9: Who was or is the greatest influence on your religious beliefs? -- Question 10: What were the religious beliefs of your family when you were growing up? -- Question 13: How much do you associate with people that hold to other religious beliefs? -- Question 15: What would be the social consequences for you if you converted to another religion? -- Sociological foundations of faith : conclusion -- Spiritual foundations of faith -- Question 4: To what extent has spiritual or religious -- Question 6: Mormons and Evangelicals claim to have the witness of the Holy Ghost/Holy Spirit in their hearts confirming the Mormons and Evangelicals -- Truth of their faith : how do you know that the assurance you have in your heart is from God? -- Question 8: What do you think of the religious experiences of people outside your religion, especially those which seem to confirm their religious beliefs to them? -- Rational foundations of faith -- Question 16: To what extent do you have faith because you think that Mormonism/Evangelicalism is reasonable? -- Question 18: What do you consider to be the best proof or evidence for Mormonism/Evangelicalism? -- Question 19: Would you believe that Mormonism/Evangelicalism is true even if most of the evidence were against it? -- Question 20: How has your assurance changed over time? -- Question 21: What has caused your faith to become stronger or weaker over time? -- Question 22: To what extent do you ever doubt that Mormonism/Evangelicalism is true? -- Question 23: If you sometimes doubt that your beliefs are true, what causes you to doubt? -- Question 24: How do you respond to or deal -- Conversion stories -- Conclusion: Foundations of faith prescribed. (shrink)

The aesthetics of everyday life, originally developed by Henri Lefebvre and other modernist theorists, is an extension of traditional aesthetics, usually confined to works of art. It is not limited to the study of humble objects but is rather concerned with all of the undeniably aesthetic experiences that arise when one contemplates objects or performs acts that are outside the traditional realm of aesthetics. It is concerned with the nature of the relationship between subject and object. One significant aspect of (...) everyday aesthetics is environmental aesthetics, whether constructed, as a building, or manipulated, as a landscape. Others, also discussed in the book, include sport, weather, smell and taste, and food. (shrink)

This volume collects contributions from leading scholars of early modern philosophy from a wide variety of philosophical and geographic backgrounds. The distinguished contributors offer very different, competing approaches to the history of philosophy.

Fundamentals -- Beginning-of-life issues -- Reproductive technologies -- Contraception, sterilization, and natural family planning -- End-of-life issues -- Cooperation with evil -- Respect for the body -- The ten commandments for health care professionals and patients.

Davidson's account of weakness of will dependsupon a parallel that he draws between practicaland theoretical reasoning. I argue that theparallel generates a misleading picture oftheoretical reasoning. Once the misleadingpicture is corrected, I conclude that theattempt to model akratic belief on Davidson'saccount of akratic action cannot work. Thearguments that deny the possibility of akraticbelief also undermine, more generally, variousattempts to assimilate theoretical to practicalreasoning.

The knowledge norm of assertion is mainly in competition with a high probability or rational credibility norm. The argument for the knowledge norm that I offer turns on cases in which a hearer responds to a speaker's assertion by asserting another sentence that would lower the probability of the speaker's assertion, were its probability less than one. In cases like this, though with qualifications, is the hearer's contribution a challenge to the speaker's assertion or complementary to it? My answer is (...) the latter, and that only the knowledge norm yields that answer.The cases that I rely on follow from an elementary probability relation, though one that is inconsistent with the still influential relevance criterion for confirmation and evidence . Assume, for illustrative purposes, that p is in your belief corpus, as a consequence of your believing ∨ ∨ . 1 You learn that ∼ & ∼ , which would lessen the probability of p, were its probability less than one, 2 since it eliminates two rows of the truth-table in which p holds. What conclusion do you reach about p?Rather than withdrawing p, you acquire the belief that p & ∼ s & ∼ r, even though Formula where pr would be the subjective or epistemic probability of p on a probabilistic view of the knowledge norm before learning ∼ & ∼ . Instead of withdrawal …. (shrink)

A critique of conversational epistemic contextualism focusing initially on why pragmatic encroachment for knowledge is to be avoided. The data for pragmatic encroachment by way of greater costs of error and the complementary means to raise standards of introducing counter-possibilities are argued to be accountable for by prudence, fallibility and pragmatics. This theme is sharpened by a contrast in recommendations: holding a number of factors constant, when allegedly higher standards for knowing hold, invariantists still recommend assertion (action), while contextualists do (...) not. Given the knowledge norm of assertion, if one recommendation is preferable to the other, the result favors the preferred recommendation's account of knowledge. In the final section, I offer a unification of these criticisms centering on the contextualist use of 'epistemic position'. Their use imposes on threshold notions of justification, warrant, or knowledge tests that are suitable only to unlimited comparative or scalar notions like confidence or certainty and places them at one with an important strand of sceptical reasoning. (shrink)

Fair lotteries offer familiar ways to pose a number of epistemological problems, prominently those of closure and of scepticism. Although these problems apply to many epistemological positions, in this paper I develop a variant of a lottery case to raise a difficulty with the reliabilist's fundamental claim that justification or knowledge is to be analyzed as a high truth-ratio (of the relevant belief-forming processes). In developing the difficulty broader issues are joined including fallibility and the relation of reliability to understanding.

This chapter contains sections titled: Epistemological Background Educational Applications On Not Addressing Epistemological Controversies.

Walter Sinnott-Armstrong has argued against moral intuitionism, according to which some of our moral beliefs are justified without needing to be inferred from any other beliefs. He claims that any prima facie justification some non-inferred moral beliefs might have enjoyed is removed because many of our moral beliefs are formed in circumstances where either (1) we are partial, (2) others disagree with us and there is no reason to prefer our moral judgement to theirs, (3) we are emotional in a (...) way that clouds our judgement, (4) the circumstances are conducive to illusion, or (5) the source of our moral beliefs is unreliable or disreputable. I take issue with the elements of Sinnott-Armstrong’s argument that centre on (1) to (3) and (5), concluding that his case against moral intuitionism is unpersuasive. (shrink)