Concepts of space and time are widely developed in physics. However, there is a considerable lack of biologically plausible theoretical frameworks that can demonstrate how space and time dimensions are implemented in the activity of the most complex life-system – the brain with a mind. Brain activity is organized both temporally and spatially, thus representing space-time in the brain. Critical analysis of recent research on the space-time organization of the brain’s activity pointed to the existence of so-called operational space-time in (...) the brain. This space-time is limited to the execution of brain operations of differing complexity. During each such brain operation a particular short-term spatio-temporal pattern of integrated activity of different brain areas emerges within related operational space-time. At the same time, to have a fully functional human brain one needs to have a subjective mental experience. Current research on the subjective mental experience offers detailed analysis of space-time organization of the mind. According to this research, subjective mental experience (subjective virtual world) has definitive spatial and temporal properties similar to many physical phenomena. Based on systematic review of the propositions and tenets of brain and mind space-time descriptions, our aim in this review essay is to explore the relations between the two. To be precise, we would like to discuss the hypothesis that via the brain operational space-time the mind subjective space-time is connected to otherwise distant physical space-time reality. (shrink)

In this paper we aim to show that phenomenal consciousness is realized by a particular level of brain operational organization and that understanding human consciousness requires a description of the laws of the immediately underlying neural collective phenomena, the nested hierarchy of electromagnetic fields of brain activity – operational architectonics. We argue that the subjective mental reality and the objective neurobiological reality, although seemingly worlds apart, are intimately connected along a unified metastable continuum and are both guided by the universal (...) laws of the physical world such as criticality, self-organization and emergence. (shrink)

In our contribution we will observe phenomenal architecture of a mind and operational architectonics of the brain and will show their intimate connectedness within a single integrated metastable continuum. The notion of operation of different complexity is the fundamental and central one in bridging the gap between brain and mind: it is precisely by means of this notion that it is possible to identify what at the same time belongs to the phenomenal conscious level and to the neurophysiological level of (...) brain activity organization, and what mediates between them. Implications for linguistic semantics, self-organized distributed computing algorithms, artificial machine consciousness, and diagnosis of dynamic brain diseases will be discussed briefly. (shrink)

Instead of using low-level neurophysiology mimicking and exploratory programming methods commonly used in the machine consciousness field, the hierarchical Operational Architectonics (OA) framework of brain and mind functioning proposes an alternative conceptual-theoretical framework as a new direction in the area of model-driven machine (robot) consciousness engineering. The unified brain-mind theoretical OA model explicitly captures (though in an informal way) the basic essence of brain functional architecture, which indeed constitutes a theory of consciousness. The OA describes the neurophysiological basis of the (...) phenomenal level of brain organization. In this context the problem of producing man-made “machine” consciousness and “artificial” thought is a matter of duplicating all levels of the operational architectonics hierarchy (with its inherent rules and mechanisms) found in the brain electromagnetic field. We hope that the conceptual-theoretical framework described in this paper will stimulate the interest of mathematicians and/or computer scientists to abstract and formalize principles of hierarchy of brain operations which are the building blocks for phenomenal consciousness and thought. (shrink)

We would like to thank all the commentators who responded to our target review paper for their thought-provoking ideas and for their initially positive characterization of our theorizing. Our position provoked a broad range of reactions, from enthusiastic support to some kind of opposition. Regardless of the type of the response, one common factor appears to be the plausibility of a presented attempt to apply insights from physics, biology (neuroscience), and phenomenology of mind to form a unified theoretical framework of (...) Operational Architectonics of brain-mind functioning. (shrink)

To build a true conscious robot requires that a robot’s “brain” be capable of supporting the phenomenal consciousness as human’s brain enjoys. Operational Architectonics framework through exploration of the temporal structure of information flow and inter-area interactions within the network of functional neuronal populations [by examining topographic sharp transition processes in the scalp electroencephalogram (EEG) on the millisecond scale] reveals and describes the EEG architecture which is analogous to the architecture of the phenomenal world. This suggests that the task of (...) creating the “machine” consciousness would require a machine implementation that can support the kind of hierarchical architecture found in EEG. (shrink)

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Rapid individual cognitive phenotyping holds the potential to revolutionize domains as wide‐ranging as personalized learning, employment practices, and precision psychiatry. Going beyond limitations imposed by traditional lab‐based experiments, new efforts have been underway toward greater ecological validity and participant diversity to capture the full range of individual differences in cognitive abilities and behaviors across the general population. Building on this, we developed Skill Lab, a novel game‐based tool that simultaneously assesses a broad suite of cognitive abilities while providing an engaging (...) narrative. Skill Lab consists of six mini‐games as well as 14 established cognitive ability tasks. Using a popular citizen science platform (N = 10,725), we conducted a comprehensive validation in the wild of a game‐based cognitive assessment suite. Based on the game and validation task data, we constructed reliable models to simultaneously predict eight cognitive abilities based on the users’ in‐game behavior. Follow‐up validation tests revealed that the models can discriminate nuances contained within each separate cognitive ability as well as capture a shared main factor of generalized cognitive ability. Our game‐based measures are five times faster to complete than the equivalent task‐based measures and replicate previous findings on the decline of certain cognitive abilities with age in our large cross‐sectional population sample (N = 6369). Taken together, our results demonstrate the feasibility of rapid in‐the‐wild systematic assessment of cognitive abilities as a promising first step toward population‐scale benchmarking and individualized mental health diagnostics. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

What the present work aimed to achieve is an assessment of the origin an d unity of Husserl s Logical Investigations. My approach was to take the history of its development as fundamental for the determination of its basic structure. Therefore, I proceeded to analyse Husserl s development between the Philosophy of Arithmetic and Logical Investigations with re spect to the fundamental issues in the justification of knowledge in mathematics and logic. In Husserl s own words, one of the concerns (...) that set him on the road to phenomenology was the clarification and analysis of the relation b etween the subjectivity of knowing and the objectivity of knowledge. Fro m my investigations it has, I hope, become apparent how this problem ori ginated in his earliest works and, through various influences and exchanges, led to his theory of intentionality in the first editio n of the Logical Investigations. The Logical Investigations is located between his Brentanist phase and t he ultimate development of transcendental phenomenology. It is the sedim ent of Husserl s logical investigations during the 1890s, which is the m ain period I analysed in the present work. Husserl himself often remarke s on the early origin of some of the issues he tried to deal with in the Logical Investigations. Still in his sketches for a new preface to the second edition of 1913, he took pains to point out the developmental his tory of the work from the Philosophy of Arithmetic onward. Regarding the Philosophy of Arithmetic, more often than not, Husserl remarks that it was just and elaboration of his Habilitationsschrift. Hence, following h is lead, we tried to embrace the whole period of his psychological and l ogical analyses from 1886/7 to 1900/01. Of course, I was certainly not the first, nor will I be the last, to be intrigued by Husserl s development in these years. Numerous books and articles have been written long before mine on precisely these issue s, often dealing with specific topics, such as the uneasy relation of psychology and psychologism in Husserl s work or fundamental inʂ 58;uences such as Bolzano s, which I therefore chose to leave aside. Not simply to duplicate or summarise such pre-existing scholarship, I tried to concentrate on the issues to which I felt I could contribute an orig inal insight, advancing the field. I would like to indicate ᤙ 7;ve points here, where I think I attained this goal: 1. The enduring relevance of Husserl s mathematical ba ckground. 2. Support for an early development of a theory of hig her order objects 3. A better evaluation of Frege s influence 4. A contextualisation of Schuhmann s thesis regarding the relevance of Twardowski for Husserl s notion of intentionality 5. The dependence of the unity of the Logical Investig ations on its historical development. Without understanding its developmental history we would misunderstand i ts internal coherence. In the first part we saw Husserl s early struggle to integrate the mathematical and psychological points of view on the philosophy of math ematics, a struggle that lasted from the Habilitationsschrift at least u p to and including his Doppelvortrag. The basic problem is the justi@ 257;cation of knowledge, in the case of mathematics, the justifica tion of knowledge in formal sciences, obtained with symbolic methods. Su ch problems regarding the subjectivity of knowing and the objectivity of knowledge guided the development of his position from Philosophy of Ari thmetic to Logical Investigations. In articulating his solution Husserl analysed the various relations betw een founding and founded layers of knowledge and whether and how one cou ld pass from on to the other. Already at the time of the Philosophy of A rithmetic he tried to account for higher order acts, relations and objec ts, the mature account of which would have to wait until the Logical Inv estigations and later. Among various influences on his progression towards phenomenology, Frege has been often considered to have provided the conversion to an ti-psychologism with his review of the Philosophy of Arithmetic. I think I have demonstrated that the review is almost entirely irrelevant in th is sense and that we should rather look at a much earlier influenc e on the Philosophy of Arithmetic. By showing that Brentano s conception of intentionality was already more sophisticated than until recently assumed, thanks to some recent public ations of unpublished material from Brentano s and Husserl s Nachlass, I think Schuhmann s thesis is right, but should be reinterpreted as being less radical than it would appear. Both Husserl and Twardowski were in& #64258;uenced by Brentano as his students. Following his and Meinong s l ead, they both elaborated a theory on intentionality, in connection with the other theories of intentionality in his school and the Brentano-Bol zano paradox. Furthermore, by providing a more continuous reading of Hus serl s development through the transcendental turn, I hope to have made clear that his later theory of the noema is not a return to a neo-Twardo wskian triadic position, but a reaffirmation, now in transcendental key, of his 1894 take on the matter. The Logical Investigations are uniquely determined by their historical c ontext in the middle of Husserl s development, falling almost exactly be tween the Habilitationsschrift and the Ideas. Due to their troubled hist ory, including changes in Husserl s earliest position around 1890, the f ailure of the second volume of the Philosophy of Arithmetic, various in& #64258;uences around 1894, and the subsequent reorientation and broadeni ng of his theories to a non-psychologistic logic and mathesis universali s, the Logical Investigations might at first seem to fall apart in two fundamentally disconnected books, the second one of which containin g six heterogeneous studies. It is my contention that it is exactly its troubled history that ties the Logical Investigations together, as Husse rl developed his logical investigations in the 1890s on the basis of a h andful thorny problems, including intentionality as centerpiece. From th e Habilitationsschrift to the Ideas it is the relation between subject a nd object, in all respects, ontological as well as epistemological, that guides his research. The Logical Investigations is a intermediate sedim ent of his struggles, containing an elaboration and improvement of his p osition in his early works and also pointing ahead towards the later pos ition of transcendental phenomenology as an implication and continuation of the solutions he proposes. Furthermore, I tried to address the problem that, while Husserl regarded his Logical Investigations as the breakthrough to phenomenology, many f undamental notions of the later transcendental phenomenology seem to be missing in the first edition of the Logical Investigations. The me thod of the reduction, the notion of a pure ego and a full account of th e noema are at most sketched or implied. Hence, I also looked ahead to t he further development of phenomenology after the Logical Investigations. As Husserl s influence has extended beyond the movement he found ed, I felt I could not bypass his significance for the currently d ominant analytical philosophy. Especially with respect to some of the co re topics of the Logical Investigations, but also earlier themes such as Husserl s semiotics, there is an interest in phenomenology from the ana lytic side. Nevertheless, precisely with regard to the unifying theme of intentionality, analytical philosophy often seems to miss the mark, and spectacularly so. I discussed Searle s influential, but in my opi nion, misguided and flawed approach, and I hope it is clear that I have chosen my method and approach in complete antithesis to his. The central contributions I was able to give, were only possible thanks to solid historical groundwork as necessary prerequisite for systematic analyses. Wherever possible, a reference to the original primary sources was provided, allowing the texts to speak for themselves and providing the reader with the critical instruments to evaluate my interpretations. As Husserl stood in a fruitful exchange with many other scholars, as st udent, colleague, friend and teacher, the intellectual context of his th oughts is essential to a correct understanding of his theories and aims. I hope to have found the right balance in the historical and the system atical aspects of my work to suit the interests of the reader and the re quirements of scholarship. (shrink)

El presente texto es un primer acercamiento a la tensión entre las necesidades y preferencias, a partir de dos pensadores significativos para la Teoría Crítica. Herbert Marcuse, miembro de la primera generación de la Escuela de Frankfurt, y Franz Hinkelammert, referente de una renovada Teoría Crítica nacida y continuada creativamente en América Latina. Pensadores que darán elementos esclarecedores para profundizar una problemática que nos preocupa hace tiempo: la cooptación de los deseos y su metamorfosis en necesidades como mecanismo de dominación (...) que opera, no ya en la conciencia sino en la misma sensibilidad humana. (shrink)

El presente estudio, centrado en el análisis del círculo he r menéutico de los t e xtos s e gún la f ilosofía de P aul Ricoeu r , tiene como f inalidad última la e xplicitación de la dob l e ta r e a que se le supone a toda filosofía hermenéutica que trate de superar de f init iv amente las presuposiciones psicológicas y e xistenciales en las que cae la vieja hermenéutica tradi- cional: por un lado, (...) se trata de buscar en el texto mismo , y no fuera de él, la " dinámica interna " de sentido que preside la est r uctura de toda obra de lenguaje; por el otro, el poder que tiene ésta de "p ro yectarse fue r a de sí misma y de engend r ar un mundo que será ve r dade r amente la "cosa" del text o ", y que lo distinguirá claramente de las relaciones orales. Esta do b le tarea hermenéutica, especi f icada en nuestro caso en el ámbito jurídic o , nos permitirá defender aquí una concepción textual del de r e c h o. (shrink)

F. H. Bradley (1846–1924) was the foremost philosopher of the British Idealist school, which came to prominence in the second half of the nineteenth century and remained influential into the first half of the twentieth. Bradley, who was influenced by Hegel and also reacted against utilitarianism, was recognised during his lifetime as one of the greatest intellectuals of his generation, and was the first philosopher to receive the Order of Merit, in 1924. In this major work, originally published in 1883, (...) Bradley discusses the basic principles of logic: judgment and inference. He rejects the idea of a separation between mind and body, arguing that human thought cannot be separated from its worldly context. In the second edition, published in 1922 and reissued here, Bradley added a commentary and essays, but left the text largely unaltered. Volume 1 contains Book 1 on judgment and Book 2 on inference. (shrink)

This work combines two early pamphlets by F. H. Bradley (1846–1924), the foremost philosopher of the British Idealist movement. The first essay, published in 1874, deals with the nature of professional history, and foreshadows some of Bradley's later ideas in metaphysics. He argues that history cannot be subjected to scientific scrutiny because it is not directly available to the senses, meaning that all history writing is inevitably subjective. Though not widely discussed at the time of publication, the pamphlet was influential (...) on historian and philosopher R. G. Collingwood. The second pamphlet is Bradley's critique of Henry Sidgwick's The Methods of Ethics. Sidgwick was the first to propose the paradox of hedonism, which is the idea in ethics that pleasure can only be acquired indirectly. Published in 1877, this work is divided into three parts, treating Sidgwick's definitions, arguments, and his view of ethical science. (shrink)

This commentary focuses on the stimulus-reinforcer hypothesis of resistance to change. The overall context of reinforcement can account for resistance to extinction. There are ways to systematically test the hypothesis that Pavlovian contingencies account for the behavioral “mass” of discriminated operant behavior.

_Heidegger_ is a classic introduction to Heidegger's notoriously difficult work. Truly accessible, it combines clarity of exposition with an authoritative handling of the subject-matter. Richard Polt has written a work that will become the standard text for students looking to understand one of the century's greatest minds.

This work combines two early pamphlets by F. H. Bradley , the foremost philosopher of the British Idealist movement. The first essay, published in 1874, deals with the nature of professional history, and foreshadows some of Bradley's later ideas in metaphysics. He argues that history cannot be subjected to scientific scrutiny because it is not directly available to the senses, meaning that all history writing is inevitably subjective. Though not widely discussed at the time of publication, the pamphlet was influential (...) on historian and philosopher R. G. Collingwood. The second pamphlet is Bradley's critique of Henry Sidgwick's The Methods of Ethics. Sidgwick was the first to propose the paradox of hedonism, which is the idea in ethics that pleasure can only be acquired indirectly. Published in 1877, this work is divided into three parts, treating Sidgwick's definitions, arguments, and his view of ethical science. (shrink)

"Not only one of the best but also the most comprehensive treatment of Stoicism written in this century." --Times Literary Supplement.

La posmodernidad es una tendencia emergente a lo largo del siglo XX, un proceso general de la cultura occidental que fue aglutinando síntomas contrapuestos, y que acabó por dominar la escena filosófico-cultural a medida que avanzaba el siglo. En la época de la multiplicación de los discursos y del triunfo universal del mercado, y tras la pérdida posmoderna de los horizontes totalizantes de la civilización, se impone cartografiar de nuevo nuestra comprensión de la realidad. Índice: Prólogo de Miguel Morey.- Introducción.- (...) Notas para una genealogía de la posmodernidad.- De la crítica de la alienación a la fragmentación de la subjetividad.- Últimas tribulaciones (¿la decadencia de la posmodernidad?).- Cronología filosófica del siglo posmoderno.- Bibliografía. (shrink)

This work combines two early pamphlets by F. H. Bradley, the foremost philosopher of the British Idealist movement. The first essay, published in 1874, deals with the nature of professional history, and foreshadows some of Bradley's later ideas in metaphysics. He argues that history cannot be subjected to scientific scrutiny because it is not directly available to the senses, meaning that all history writing is inevitably subjective. Though not widely discussed at the time of publication, the pamphlet was influential on (...) historian and philosopher R. G. Collingwood. The second pamphlet is Bradley's critique of Henry Sidgwick's The Methods of Ethics. Sidgwick was the first to propose the paradox of hedonism, which is the idea in ethics that pleasure can only be acquired indirectly. Published in 1877, this work is divided into three parts, treating Sidgwick's definitions, arguments, and his view of ethical science. (shrink)