Neural Synchrony and Binding

While there is still a limited understanding of the Selfhood phenomenon, an emerging consensus is that the experiential Selfhood refers to a sense of the undergoing experience in its implicit first-person mode of givenness that is immediately and tacitly given as “mine”. It is also evident that there are phenomenological disruptions within self-consciousness ranging from normal everyday short-lived dissociative episodes to pathological, intense and prolonged forms of dissociative experience classified as depersonalization disorder (DD). In the present study we explored the (...) neurophenomenology of Selfhood (using the recently introduced neurophysiological three-dimensional construct model of experiential Selfhood, Fingelkurts et al., 2020) in a newly diagnosed and untreated 29-year-old female who suffers from DD. According to the triad model of Selfhood, three major components of Selfhood (phenomenal first-person agency – “Self”, embodiment – “Me”, and reflection/narration – “I”) are related to three operational modules (OMs) of the self-referential brain network (reliably estimated by electroencephalogram operational synchrony analysis). We have found that subject with DD exhibited a strong enhancement of functional integrity of the brain Self-module, a moderate decrease in the functional integrity of Me-module, and a pronounced decrease in the functional integrity of I-module, – all of which were associated with severity of specific DD symptoms. (shrink)

A new strategy for moving forward in the characterization of the Global Neuronal Workspace (GNW) is proposed. According to Dehaene, Changeux and colleagues, broadcasting is the main function of the GNW. However, the dynamic network properties described by recent graph-theoretic GNW models are consistent with many large-scale communication processes that are different from broadcasting. We propose to apply a different graph-theoretic approach, originally developed for optimizing information dissemination in communication networks, which can be used to identify the pattern of frequency (...) and phase-specific directed functional connections that the GNW would exhibit only if it were a broadcasting network. (shrink)

While we perceive events in our environment through multiple sensory systems, we nevertheless perceive all of these events as occupying a single unified timeline. Time, as we perceive it, is unified. I argue that existing accounts of the perceived unity of time fail. Instead, the perceived unity of time must be constructed by integrating our initially fragmented timekeeping capacities. However, existing accounts of multimodal integration do not tell us how this might occur. Something new is needed. I finish the paper (...) by articulating the hurdles that must be overcome to provide an account of the perceived unity of time. (shrink)

Color-motion asynchrony (CMA) refers to an apparent lag of direction of motion when a dynamic stimulus changes both color and direction at the same time. The subjective order of simultaneous events, however, is not only perceptual but also subject to illusions during voluntary actions. Self-initiated actions, for example, seem to precede their sensory outcomes following an adaptation to a delay between the action and the sensory feedback. Here, we demonstrate that the extent of the apparent asynchrony can be substantially reduced (...) when direction change is induced by a voluntary key press following a delay adaptation regime. We also show that the reduced color-motion asynchrony effect size following a motor-sensory recalibration is not a result of a change in the onset of perceived direction change relative to that of the color. This is particularly important as it implies, for the first time in the literature, that voluntary action is not only important in forming action-sensory outcome associations but may also act as a binding factor between the two perceptual features of a sensory event. (shrink)

One of the aspects of consciousness is the fact that it is formed from unifications of qualia. In this paper, unification will be shown to be a phenomenon that works based on the unformal nature of self-reference. Self-reference being an unformal entity, it is no-thing and every-thing both at the same time. These unformal properties will be shown to play an essential role in the existence and manifestation of unification. The best exemplification of the unformal workings of unification will be (...) shown to happen in the phenomenon of telepathy. Telepathy will be argued to be a case of consciousness unification and will be shown that its imperfection is not a reason for rejecting it, but is a door towards the workings of the phenomenon of unification. (shrink)

Objetivo. Verificar si el procesamiento semántico de estímulos visuales complejos, como la repetición, la identidad, el orden y la doble incongruencia, es recursivo o computable. Sujetos y métodos. Veintisiete universitarios respondieron a un paradigma adaptado N400 con cinco condiciones, cada una con 80 tareas, mientras se registraba su actividad cerebral con un gorro de 64 electrodos. Resultados. Dos ventanas temporales de 400 a 550 ms y de 550 a 800 ms se analizaron mediante un contraste ANOVA del factor condición por (...) regiones de interés. Además, se calculó la solución inversa de las ventanas mediante tomografía electromagnética de baja resolución para identificar las fuentes corticales subyacentes a los potenciales eléctricos. Se corroboran diferencias significativas (p< 0, 05) en los potenciales N400 y P600 en áreas frontales y centroparietales asociadas a los operadores lógicos estudiados. Conclusión. Se confirma que el procesamiento cerebral de imágenes complejas (congruentes/incongruentes) es modulado por la repetición, la identidad y el orden, pero no por la negación. Por consiguiente, se puede decir que el procesamiento semántico de imágenes complejas es semicomputable. (shrink)

The target paper of Schoeller, Perlovsky, and Arseniev is an essential and timely contribution to a current shift of focus in neuroscience aiming to merge neurophysiological, psychological and physical principles in order to build the foundation for the physics of mind. Extending on previous work of Perlovsky et al. and Badre, the authors of the target paper present interesting mathematical models of several basic principles of the physics of mind, such as perception and cognition, concepts and emotions, instincts and learning. (...) Their conceptualization helps to clarify the distinction between conscious and unconscious aspects of mind that is often neglected and further provide a clear description of the mental hierarchy, which extends from physical objects in the physical world to abstract ideas in the mental/subjective realm. While we agree that identification of a few fundamental principles is a first step toward developing the physics of the mind, and we concur with the selection of those principles in the target review paper, we think that the theory of the physics of mind would much benefit from considering also the most basic principles that are common for the physics/matter/brain and the mind/subjectivity/cognition. In this respect, such basic principles as time and space, as well as criticality, self-organization, and emergence seem to be the most interesting. (shrink)

Based on previous studies implicating increased functional connectivity within the self-referential brain network in major depressive disorder (MDD), and considering the functional roles of three distinct modules of such brain net (responsible for three-dimensional components of Selfhood) together with the documented abnormalities of self-related processing in MDD, we tested the hypothesis that patients with depression would exhibit increased connectivity within each module of the self-referential brain network and that the strength of these connections would correlate positively with depression severity. Applying (...) the electroencephalogram (EEG) operational synchrony analysis to extract three modules of the self-referential brain network in 12 medication-free depressive outpatients and 10 control subjects we have found an increase in the strength of EEG synchrony within all three modules in depressive patients (though non-significant for the right module). Furthermore, multiple regression analysis that used 3 factors (values of synchrony strength for all three modules) as input indicated that combined increase in the strength of synchrony in all three modules was positively associated with severity of depression. Taken together the findings of this study suggest that depression is primarily associated with hypersynchrony in all three modules of the brain self-referential network (the anterior module been responsible for “witnessing observation and first–person perspective”, the left posterior module been responsible for “reflective agency and narration” and the right posterior module been responsible for “bodily representational-emotional agency”), thus contributing to excessive self-focus, rumination, and body tension. (shrink)

In this brief overview paper, we analyse information flow in the brain. Although Shannon’s information concept, in its pure algebraic form, has made a number of valuable contributions to neuroscience, information dynamics within the brain is not fully captured by its classical description. These additional dynamics consist of self-organisation, interplay of stability/instability, timing of sequential processing, coordination of multiple sequential streams, circular causality between bottom-up and top-down operations, and information creation. Importantly, all of these processes are dynamic, hierarchically nested and (...) correspond to continuous brain state change, even if the external environment remains constant. This is where metastable coordination comes into play. In a metastable regime of brain functioning, as a result of the simultaneous co-existence of tendencies for independence and cooperation, information is continuously created, preserved for some time and then dissipated through the formation of dynamical and nested spatio-temporal coalitions among simple neuronal assemblies and larger coupled conglomerates of them—so-called delocalised operational modules. (shrink)

Evidence that minds are neural electromagnetic fields comes from research into how separate brain activities bind to form unified percepts and unified minds. Explanations of binding using synchrony, attention, and convergence are all problematic. But the unity of EM fields explains binding without these problems. These unified fields neatly explain correlations and divergences between synchrony, attention, convergence, and unified minds. The simplest explanation for the unity of both minds and fields is that minds are fields. Treating minds as the fields' (...) underlying, intrinsic nature has the further virtue of avoiding mind-body problems. There's also rising evidence that EM fields interact with brains. McFadden argues here that fields help shift the focus of attention by initiating synchrony in different neural networks, which boosts their own fields and thereby binds their activity. This evidence that minds are fields that bind and guide brain activities supports free will over epiphenomenalism and supervenience. (shrink)

The brain displays both the anatomical features of a vast amount of interconnected topological mappings as well as the functional features of a nonlinear, metastable system at the edge of chaos, equipped with a phase space where mental random walks tend towards lower energetic basins. Nevertheless, with the exception of some advanced neuro-anatomic descriptions and present-day connectomic research, very few studies have been addressing the topological path of a brain embedded or embodied in its external and internal environment. Herein, by (...) using new formal tools derived from algebraic topology, we provide an account of the metastable brain, based on the neuro-scientific model of Operational Architectonics of brain-mind functioning. We introduce a “topodynamic” description that shows how the relationships among the countless intertwined spatio-temporal levels of brain functioning can be assessed in terms of projections and mappings that take place on abstract structures, equipped with different dimensions, curvatures and energetic constraints. Such a topodynamical approach, apart from providing a biologically plausible model of brain function that can be operationalized, is also able to tackle the issue of a long-standing dichotomy: it throws indeed a bridge between the subjective, immediate datum of the naïve complex of sensations and mentations and the objective, quantitative, data extracted from experimental neuro-scientific procedures. Importantly, it opens the door to a series of new predictions and future directions of advancement for neuroscientific research. (shrink)

Electroencephalogram (EEG) recordings are increasingly used to evaluate patients with disorders of consciousness (DOC) or assess their prognosis outcome in the short-term perspective. However, there is a lack of information concerning the effectiveness of EEG in classifying long-term (many years) outcome in chronic DOC patients. Here we tested whether EEG operational architectonics parameters (geared towards consciousness phenomenon detection rather than neurophysiological processes) could be useful for distinguishing a very long-term (6 years) clinical outcome of DOC patients whose EEGs were registered (...) within 3 months post-injury. The obtained results suggest that EEG recorded at third month after sustaining brain damage, may contain useful information on the long-term outcome of patients in vegetative state: it could discriminate patients who remain in a persistent vegetative state from patients who reach a minimally conscious state or even recover a full consciousness in a long-term perspective (6 years) post-injury. These findings, if confirmed in further studies, may be pivotal for long-term planning of clinical care, rehabilitative programs, medical-legal decisions concerning the patients, and policy makers. (shrink)

It has been argued that complex subjective sense of self is linked to the brain default-mode network (DMN). Recent discovery of heterogeneity between distinct subnets (or operational modules - OMs) of the DMN leads to a reconceptualization of its role for the experiential sense of self. Considering the recent proposition that the frontal DMN OM is responsible for the first-person perspective and the sense of agency, while the posterior DMN OMs are linked to the continuity of ‘I’ experience (including autobiographical (...) memories) through embodiment and localization within bodily space, we have tested in this study the hypothesis that heterogeneity in the operational synchrony strength within the frontal DMN OM among patients who are in a vegetative state (VS) could inform about a stable self-consciousness recovery later in the course of disease (up to six years post-injury). Using EEG operational synchrony analysis we have demonstrated that among the three OMs of the DMN only the frontal OM showed important heterogeneity in VS patients as a function of later stable clinical outcome. We also found that the frontal DMN OM was characterized by the process of active uncoupling (stronger in persistent VS) of operations performed by the involved neuronal assemblies. (shrink)

Based on the finding in novices that four months of meditation training significantly increases frontal default mode network (DMN) module/subnet synchrony while decreasing left and right posterior DMN modules synchrony, the current study tested the prediction whether experienced meditators (those who are practising meditation intensively for several years) had a change in the DMN “trinity” of modules as a baseline trait characteristic and whether this change is in a similar direction as in the novice trainees who practised meditation for only (...) four months. Comparison of functional connectivity within DMN subnets (measured by electroencephalogram operational synchrony in the three separate DMN modules) between five experienced meditators and 10 naïve participants (who were about to start the meditation training) fully support the prediction. Interpretation that links such DMN subnets changes to the three-dimensional components of the experiential selfhood was proposed. (shrink)

How do separate brain processes bind to form unified, conscious percepts? This is the perceptual binding problem, which straddles neuroscience and psychology. In fact, two problems exist here: (1) the easy problem of how neural processes are unified, and (2) the hard problem of how this yields unified perceptual consciousness. Binding theories face familiar troubles with (1) and they do not come to grips with (2). This paper argues that neuroelectrical (electromagnetic-field) approaches may help with both problems. Concerning the easy (...) problem, standard accounts of neural binding by synchrony, attention, and convergence raise serious difficulties. These are avoided by neuroelectrical approaches in which the brain’s field binds distributed processes in myriad neurons. Concerning the hard problem, binding theories do not squarely address how to get from neural unity to unified consciousness. This raises metaphysical difficulties involving reductions, emergence, etc. Neuroelectrical (and Russellian) approaches may help avoid these difficulties too. These approaches may thus deserve further investigation as binding theories. (shrink)

In this article, I examine a new concept of “Twin Memory’ which has emerged in memory classification research of conscious and unconscious memory representations. It is to analyse the presence of twin memory among the various memory systems, and also to provide a platform for the twin memory “anatomy” in the field of cognitive science, neuropsychology and neuroscience.

Research on electroencephalogram (EEG) characteristics associated with major depressive disorder (MDD) has accumulated diverse neurophysiologic findings related to the content, topography, neurochemistry, and functions of EEG oscillations. Significant progress has been made since the first landmark EEG study on affective disorders by Davidson 35 years ago. A systematic account of these data is important and necessary for building a consistent neuropsychophysiologic model of MDD and other affective disorders. Given the extensive data on frequency-dependent functional significance of EEG oscillations, a frequency (...) domain approach may reveal the types of brain functions involved and disturbed in MDD. In this review, we systematize and integrate diverse and often unconnected observations on the content, topography, neurochemistry, and functions of EEG oscillations involved in MDD within the general concept of an EEG oscillatory pattern. (shrink)

It is the every person's daily phenomenal experience that conscious states represent their contents as occurring now. Following Droege (2009) we could state that consciousness has a peculiar affinity for presence. Some researchers even argue that conscious awareness necessarily demands that mental content is somehow held “frozen” within a discrete progressive present moment. Thus, phenomenal content seems to be minimally conscious if it is integrated into a single and coherent model of reality during a “virtual window” of presence.

Neuroimaging studies of the resting state continue to gather philosophical and scientific attention. Most discussions assume an identification between resting-state activity and activity in the so-called default mode network. I argue we should resist this identification, structuring my discussion around a dilemma first posed by Morcom and Fletcher. I offer an alternative view of rest as a state dominated by long-term processes and show how interaction effects might thereby let rest shed light on short-term changes in activation.

Unresponsive wakefulness syndrome (UWS, previously known as vegetative state) occurs after patients survive a severe brain injury. Patients suffering from UWS have lost awareness of themselves and of the external environment and do not retain any trace of their subjective experience. Current data demonstrate that neuronal functions subtending consciousness are not completely reset in UWS; however, they are reduced below the threshold required to experience consciousness. The critical factor that determines whether patients will recover consciousness is the distance of their (...) neuronal functions from this threshold level. Recovery of consciousness occurs through functional and/or structural changes in the brain, i.e., through neuronal plasticity. Although some of these changes may occur spontaneously, a growing body of evidence indicates that rehabilitative interventions can improve functional outcome by promoting adaptive functional and structural plasticity in the brain, especially if a comprehensive neurophysiological theory of consciousness is followed. In this review we will focus on the pathophysiological mechanisms involved in UWS and on the plastic changes operating on the recovery of consciousness. (shrink)

This paper briefly review a current trend in neuroscience aiming to combine neurophysiological and physical concepts in order to understand the emergence of spatio-temporal patterns within brain activity by which brain constructs knowledge from multiple streams of information. The authors further suggest that the meanings, which subjectively are experienced as thoughts or perceptions can best be described objectively as created and carried by large fields of neural activity within the operational architectonics of brain functioning.

Background: Patients in a vegetative state pose problems in diagnosis, prognosis and treatment. Currently, no prognostic markers predict the chance of recovery, which has serious consequences, especially in end-of-life decision-making. Objective: We aimed to assess an objective measurement of prognosis using advanced electroencephalography (EEG). Methods: EEG data (19 channels) were collected in 14 patients who were diagnosed to be persistently vegetative based on repeated clinical evaluations at 3 months following brain damage. EEG structure parameters (amplitude, duration and variability within quasi-stationary (...) segments, as well as the spatial synchrony between such segments and the strength of this synchrony) were used to predict recovery of consciousness 3 months later. Results: The number and strength of cortical functional connections between EEG segments were higher in patients who recovered consciousness (P < .05 – P < .001) compared with those who did not recover. Linear regression analysis confirms that EEG structure parameters are capable of predicting (P = .0025) recovery of consciousness 6 months post-injury, whereas the same analysis failed to significantly predict patient outcome based on aspects of their clinical history alone (P = .629) or conventional EEG spectrum power (P = .473). Conclusions: The result of this preliminary study demonstrates that structural strategy of EEG analysis is better suited for providing prognosis of consciousness recovery than existing methods of clinical assessment and of conventional EEG. Our results may be a starting point for developing reliable prognosticators in patients who are in vegetative state, with the potential to improve their day-to-day management, quality of life, and access to early interventions. (shrink)

In this paper we aim to show that phenomenal consciousness is realized by a particular level of brain operational organization and that understanding human consciousness requires a description of the laws of the immediately underlying neural collective phenomena, the nested hierarchy of electromagnetic fields of brain activity – operational architectonics. We argue that the subjective mental reality and the objective neurobiological reality, although seemingly worlds apart, are intimately connected along a unified metastable continuum and are both guided by the universal (...) laws of the physical world such as criticality, self-organization and emergence. (shrink)

One of the final obstacles to understanding consciousness in physical terms concerns the question of whether conscious states can exist in posterior regions of the brain without active connections to the brain's prefrontal lobes. If they can, difficult issues concerning our knowledge of our conscious states can be resolved. This paper contains a list of types of conscious states that may meet this criterion, including states of coma, states in which subjects are absorbed in a perceptual task, states in brains (...) with damaged prefrontal lobes, states of meditation and conscious states of some infants and animals. Recent evidence also suggests that conscious states of some people with autism may meet this criterion. (shrink)

Neuroscience investigates how neuronal processing circuits work, but it has problems explaining experiences this way. For example, it hasn’t explained how colour and shape circuits bind together in visual processing, nor why colours and other qualia are experienced so differently yet processed by circuits so similarly, nor how to get from processing circuits to pictorial images spread across inner space. Some theorists turn from these circuits to their electromagnetic fields to deal with such difficulties concerning the mind’s qualia, unity, privacy, (...) and causality. They include Kohler, Libet, Popper, Lindahl, Arhem, Charman, Pockett, John, McFadden, Fingelkurts, Maxwell, and Jones. They’re classifiable as computationalist, reductionist, dualist, realist, interactionist, epiphenomenalist, globalist, and localist. However, they’ve never been analysed together as a whole, which hinders evaluations of them. This article tries to rectify this. It concludes that while field theories face challenges, they aren’t easily dismissed, for they draw on considerable evidence and may avoid serious problems in neuroscience concerning the mind’s qualia, unity, causality, and ontology. (shrink)

This is an introduction to the syntax, semantics and pragmatics of binding, with a special focus on the so-called principles of linguistic economy. I shall first look at the Binding Principles, and stress some of their limitations. Consequently, additional constraints are needed to complement the robust syntactic generalisations already ensured by the Binding Principles and thus to overcome their limitations. Subsequently, we shall explore the basic mechanisms underlying the reconstruction of Binding Theory under the new set of constraints introduced by (...) the economy principles. It is this variety of principles of economy that is the main theme of the present paper. I spell out the idea of linguistic economy, its ramifications as well as its explanatory uses. (shrink)

Hormonal changes associated with the human menstrual cycle have been previously found to affect female mate preference, whereby women in the late follicular phase of their cycle (i.e., at higher risk of conception) prefer males displaying putative signals of underlying genetic fitness. Past research also suggests that romantic kissing is utilized in human mating contexts to assess potential mating partners. The current study examined whether women in their late follicular cycle phase place greater value on kissing at times when it (...) might help serve mate assessment functions. Using an international online questionnaire, results showed that women in the follicular phase of their menstrual cycle felt that kissing was more important at initial stages of a relationship than women in the luteal phase of their cycle. Furthermore, it was found that estimated progesterone levels were a significant negative predictor for these ratings. (shrink)

The target paper of Dr. Feinberg is a testimony to an admirable scholarship and deep thoughtfulness. This paper develops a general theoretical framework of nested hierarchy in the brain that allows production of mind with consciousness. The difference between non-nested and nested hierarchies is the following. In a non-nested hierarchy the entities at higher levels of the hierarchy are physically independent from the entities at lower levels and there is strong constraint of higher upon lower levels. In a nested hierarchy, (...) higher levels are physically composed of lower levels, and there is no central control of the system resulting in weak constraint of higher upon lower levels. (shrink)

This chapter presents the following hypothesis: There is a perfectly sensible conception of the mind, consciousness, the self, what we mean by ‘I,’ how we perceive and know, and how we remember and decide, all of which cohere amongst one another as well as with what we know about the brain, according to which it is possible for one person to experience directly the conscious states of another person. Not only can one person be directly aware of the conscious states (...) of another person, he can be more aware of them than their original owner. He can even be aware of them when their original owner will never be aware of them. Mindmelding is possible, and this possibility removes much of the force from the mind-body problem by removing the impasse caused by the belief in privacy. It removes what some philosophers saw as a need to posit strange metaphysical categories. The subject's sense of self can be separated from the object of her conscious awareness which can be bound to another's sense of self. (shrink)

Gamma-ray bursts are the brightest--and, until recently, among the least understood--cosmic events in the universe. Discovered by chance during the cold war, these evanescent high-energy explosions confounded astronomers for decades. But a rapid series of startling breakthroughs beginning in 1997 revealed that the majority of gamma-ray bursts are caused by the explosions of young and massive stars in the vast star-forming cauldrons of distant galaxies. New findings also point to very different origins for some events, serving to complicate but enrich (...) our understanding of the exotic and violent universe. What Are Gamma-Ray Bursts? is a succinct introduction to this fast-growing subject, written by an astrophysicist who is at the forefront of today's research into these incredible cosmic phenomena. Joshua Bloom gives readers a concise and accessible overview of gamma-ray bursts and the theoretical framework that physicists have developed to make sense of complex observations across the electromagnetic spectrum. He traces the history of remarkable discoveries that led to our current understanding of gamma-ray bursts, and reveals the decisive role these phenomena could play in the grand pursuits of twenty-first century astrophysics, from studying gravity waves and unveiling the growth of stars and galaxies after the big bang to surmising the ultimate fate of the universe itself. What Are Gamma-Ray Bursts? is an essential primer to this exciting frontier of scientific inquiry, and a must-read for anyone seeking to keep pace with cutting-edge developments in physics today. (shrink)

We use a sequential voluntary contribution game to compare the relative impact of a first-mover’s non-binding announcement versus binding commitment on cooperation. We find that a non-binding announcement and a binding commitment increase individual contributions to a similar extent. Since announced contributions systematically exceed commitments, in sessions with a non-binding announcement, second-movers tend to contribute more to the group activity than in sessions with a binding commitment. Yet, second-movers appear to be more motivated towards achieving a social optimum when the (...) first-mover uses commitment. We also find that a non-binding announcement has a higher impact on individual propensity to cooperate than the ex post contribution of the first-mover. However, the failure to make announced contributions decreases cooperation even though the first-mover is reassigned in every period. (shrink)