This essay explores a variety of important Chinese conceptions of the actual and ideal relationship between human beings and the rest of the natural world. It presents views from the earliest period of historical China, the latter part of the Shang dynasty (ca. 1200–1050 bce), and from representative thinkers of other periods, extending down to the last imperial era, the Qing dynasty (1644–1911 ce). There is a fairly clear line of development from the earliest period, when the Chinese saw the (...) natural realm as chaotic, dangerous and largely inscrutable, to a later view of the world as well ordered, inclined toward human good and more open to understanding. This later view was first expressed during the “Eastern Zhou” (770–221 bce), and reached a mature and systematic form in the following Han dynasty (206 bce–220 ce). Subsequent periods saw remarkable variation in the specific features of this view but its general form – a belief in a well ordered and manageable world, inclined toward human good and open to human understanding – remained dominant throughout subsequent Chinese history. (shrink)

Mitotic recombination is a repair process which is known to repair double strand breaks and to fill double‐strand gaps by copying a homologous sequence. Meiotic recombination is a process of heteroduplex formation which sometimes generates crossovers. Evidence is presented that the later stages of meiotic recombination have some characteristics of mitotic repair recombination, leading to the conclusion that mismatch repair may be a recombinogenic repair process. The evidence suggests that the recombinational repair process generates hetero‐duplex bubbles which can move. Some (...) bubbles become crossovers. Others cease to exist, perhaps because topoisomerase activity breaks them down. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Dharma Bums: The Beat Generation and the Making of Countercultural PilgrimageP. J. JohnstonI believe in the sweetness of Jesus And Buddha— I believe, In St. Francis, Avaloki Tesvara, the Saints Of First Century India A D And Scholars Santidevan And Otherwise Santayanan Everywhere.(Kerouac 1959: 15)Preliminary Polemics“PILGRIM, n. A traveler that is taken seriously.”—Ambrose Bierce, The Devil’s Dictionary 2007: 133As Beat commentator Stephen Prothero describes in his article “On the (...) Holy Road: The Beat Movement as Spiritual Protest” (1991), the Beats and their pilgrimages have most emphatically not been taken seriously. Both critics and scholars have been unkind to members of the Beat generation, and this unkindness has manifested itself in relative neglect of the Beats in all possible aspects of scholarly investigation. But nowhere does this appear more pronounced than in the area of Beat religion. Though some recent scholarship has been picking up from this earlier neglect and it is now [End Page 165] possible to find serious biographies of most of the major Beat writers and some belated attention to the movement as a literary phenomenon, the only book-length treatment of Beat Buddhism I was able to locate (Tonkinson 1995) hardly qualifies as a scholarly work and was published not by an academic press but as a special feature of the Buddhist magazine Tricycle. Prothero hypothesizes that this is because of the movement’s reputation as rebellious and antinomian—in its heyday the movement was characterized in identical unsavory terms by publications representing interests as diverse as Life and Playboy, with the latter describing the Beats as “nihilists” and the former claiming that the Beats were at war with “Mom, Dad, Politics, Marriage, the Savings Bank, Organized Religion, Literary Elegance, Law, the Ivy League Suit and Higher Education, to say nothing of the Automatic Dishwasher, the Cellophane-wrapped Soda Cracker, the Split-Level House and the clean, or peace-provoking H-bomb” (Prothero 1991: 206). Norman Podhoretz of Partisan Review went further still, claiming that the Beats were “hostile to civilization” and that the movement as a whole amounted to “a revolt of the spiritually underprivileged and crippled of soul” and “an affirmation of death” (ibid., 206). One couldn’t ask for a more passionate disavowal of the Beats or a more thorough polemic that the movement was profoundly antireligious.This could not contrast more with the Beats’ representation of their movement and its aims, with Jack Kerouac going so far as to reinterpret the crucial term “Beat” (a term for someone down and out originally borrowed from criminal street jive) as a noun derived from the adjective “beatific,” a specifically religious term familiar from such phrases as “the beatific vision” (ibid., 206–207). Several of the representative Beat writers were practicing Buddhists, influencing the entire movement to such an extent that Buddhist ideas and imagery suffused Beat literature as a whole. Ginsberg and Kerouac especially emphasized the positive and constructive elements of their spiritual vision, arguing that literature such as On the Road and Howl should be understood as religious affirmations of what is good and holy rather than as purely critical undertakings: “For the crucifix I speak out, for the Star of Israel I speak out, for the divinest man who ever lived who was German (Bach) I speak out, for sweet Mohammed I speak out, for Buddha I speak out, for Lao-tse and Chuang-tse I speak out” (ibid., 206–207). Or, as Allen Ginsberg put it less lyrically (and rather more bluntly): “Howl is an ‘Affirmation’ by individual experience of God, sex, drugs, and absurdity... the poems are religious and I meant them to be” (ibid., 207).But for the most part, Beat asseverations in no way diminished scholarly wariness about the Beat movement and its spirituality—as Prothero concludes, “the tendency among literary scholars is to see these [religious] concerns as tangential rather than constitutive” while “historians of American religion who have explored beat spirituality have tended to focus almost exclusively on the beats’ engagement with Zen and then to dismiss that engagement as haphazard” (ibid., 207).It is my contention that the mainstream scholarly neglect of Beat spirituality is in some part... (shrink)

The Reverend Hozen Seki, President of the American Buddhist Academy, says in his two-page preface that this book is the result of the transcription of five lectures given by Suzuki in the New York Buddhist Church in 1958. It is a detailing of Suzuki's own personal view of what Shin Buddhism is. This is the system that stems from the Japanese saint Shinran of the thirteenth century who was a follower of Honen, the founder of the Pure Land doctrine in (...) Japan. The aim of the book is not to trace down the background of the Pure Land teaching in India, nor is it to present Shinran's teaching as is. Rather, it is an expression of Suzuki's own insights into the Pure Land teaching.--P. J. H. (shrink)

Introduction: The Dutch Euthanasia Act states that euthanasia is not punishable if the attending physician acts in accordance with the statutory due care criteria. These criteria hold that: there should be a voluntary and well-considered request, the patient’s suffering should be unbearable and hopeless, the patient should be informed about their situation, there are no reasonable alternatives, an independent physician should be consulted, and the method should be medically and technically appropriate. This study investigates whether physicians experience problems with these (...) criteria in medical practice.Methods: In 2006, questionnaires were sent to a random, stratified sample of 2100 Dutch physicians . Physicians were asked about problems in their decision-making related to requests for euthanasia or assisted suicide after enforcement of the 2002 Euthanasia Act.Results: Of all physicians who had received a request for euthanasia or assisted suicide , 25% had experienced problems in the decision-making with regard to at least one of the criteria of due care. Physicians who had experienced problems mostly indicated to have had problems related to evaluating whether or not the patient’s suffering was unbearable and hopeless and whether or not the patient’s request was voluntary or well considered .Discussion: Physicians in The Netherlands most frequently reported problems related to aspects in which they have to evaluate the patient’s subjective perspective. However, it can be questioned whether placing emphasis on these subjective aspects is an adequate fulfilment of the duties imposed on physicians, as laid down in the Dutch Euthanasia Act. (shrink)

Despite the frequency of stillbirths, the subsequent implications are overlooked and underappreciated. We present findings from comprehensive, systematic literature reviews, and new analyses of published and unpublished data, to establish the effect of stillbirth on parents, families, health-care providers, and societies worldwide. Data for direct costs of this event are sparse but suggest that a stillbirth needs more resources than a livebirth, both in the perinatal period and in additional surveillance during subsequent pregnancies. Indirect and intangible costs of stillbirth are (...) extensive and are usually met by families alone. This issue is particularly onerous for those with few resources. Negative effects, particularly on parental mental health, might be moderated by empathic attitudes of care providers and tailored interventions. The value of the baby, as well as the associated costs for parents, families, care providers, communities, and society, should be considered to prevent stillbirths and reduce associated morbidity. (shrink)

I criticize the view that top-down causation is a proper model for depicting and justifying belief in mental causation. When properly interpreted, I believe that there are no clear examples of top-down causation, and there is a persuasive case against it. In order to defend these claims, I, first, clarify three preliminary considerations; second, undermine alleged examples of top-down causation; third, present a case for why there is no top-down mental causation; fourth, explain an important option for moving forward in (...) preserving what we all know to be the case—that mental causation is real. (shrink)

In recent years, many philosophers of modern physics came to the conclusion that the problem of how objectivity is constituted (rather than merely given) can no longer be avoided, and therefore that a transcendental approach in the spirit of Kant is now philosophically relevant. The usual excuse for skipping this task is that the historical form given by Kant to transcendental epistemology has been challenged by Relativity and Quantum Physics. However, the true challenge is not to force modern physics into (...) a rigidly construed static version of Kant's philosophy, but to provide Kant's method with flexibility and generality. In this book, the top specialists of the field pin down the methodological core of transcendental epistemology that must be used in order to throw light on the foundations of modern physics. First, the basic tools Kant used for his transcendental reading of Newtonian Mechanics are examined, and then early transcendental approaches of Relativistic and Quantum Physics are revisited. Transcendental procedures are also applied to contemporary physics, and this renewed transcendental interpretation is finally compared with structural realism and constructive empiricism. The book will be of interest to scientists, historians and philosophers who are involved in the foundational problems of modern physics. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

The research addressed the issue of symbolic walls that divide, segregate, preserve and institutionalise. The way in which institutions and especially the Faculty of Theology at the University of Pretoria facilitated symbolic ‘walls’ was discussed in the overview of the Department of Science of Religion and Missiology in the first century of the Faculty of Theology. The concepts of ‘gatekeepers’ and ‘traders’ were then applied because walls, paradoxically, need gates to facilitate control, movement and, eventually, life. Gatekeepers were described as (...) the guardians of the status quo, and traders as agents who, in one way or another, facilitate movement, trade, flow and life in the midst of the shadows of walls. Missionaries are, by the very nature of the missionary enterprise, more traders than gatekeepers. Here, the work of Bosch – specifically his ground-breaking work on mission as contextualisation – provides an explanation of the art of mission as breaking down walls, opening gates and empowering traders. That is precisely why Missiology is particularly well suited to assist the church and theology in the art of breaking down walls. The theological imperative of contextualisation means that the life of the church, theology, and thus theological training, cannot do without Missiology. The concept of ‘deep contextualisation’ was discussed as a particularly relevant approach to include a post-anthropomorphic discourse in Missiology. It can assist with the reorientation of the history of mission on the whole of history and, thus, also deep history. The concept also provides a way to address the discourses on colonialisation and includes a reorientation on the future and embracing hope. (shrink)

These lines conclude the speech of Pompey to Cornelia when she met him on the shore of Lesbos after the disaster of Pharsalia. This speech Mr. Heitland in his excellent Introduction to Haskins' Lucan has stigmatised as ‘abominable’.1 So far as the bulk of the speech is concerned a plea may perhaps be urged in mitigation of this judgment. Cornelia has completely broken down at the sight of her unfortunate husband, and his first object should be to restore her to (...) herself. For this purpose, as all, not excluding Lucan, know, a tone of sharp chiding would be most effectual, and we learn from the sequel that it succeeded : ‘uocibus his correpta uiri uix aegra leuauit | membra solo’ . For the crude brutality of the statement in the last four words there is however no excuse. But happily it is not to be charged to Pompey or to Lucan, but to the editions. We should punctuate. (shrink)

Since the time of Burman it has been amongst the aims of Phaedrian scholarship to endeavour to make good the imperfections of the direct tradition by recourse to the indirect. That losses have been sustained, one piece of evidence is enough to show. In the sixth line of his Preface to Book I. Phaedrus says that trees speak in his fables; but no trees speak in any fable now left to us, either in the five books as handed down in (...) PR or in the Perottine Appendix. (shrink)

How can cooperation be achieved between self-interested individuals in commonly-occurring asymmetric interactions where agents have different positions? Should agents use the same strategies that are appropriate for symmetric social situations? We explore these questions through the asymmetric interaction captured in the indefinitely repeated investment game (IG). In every period of this game, the first player decides how much of an endowment he wants to invest, then this amount is tripled and passed to the second player, who finally decides how much (...) of the tripled investment she wants to return to the first player. The results of three evolutionary studies demonstrate that the best-performing strategies for this asymmetric game differ from those for a similar but symmetric game, the indefinitely repeated Prisoner’s dilemma game. The strategies that enable cooperation for the asymmetric IG react more sensitively to exploitation, meaning that cooperation can more easily break down. Furthermore, once cooperation has stopped, it is much more difficult to reestablish than in symmetric situations. Based on these results, the presence of asymmetry in an interaction appears to be an important factor affecting adaptive behavior in these common social situations. (shrink)

Doctors are regularly confronted with requests for sterilisation of mentally handicapped people who cannot give consent for themselves. They ought to act in a medical vacuum because there doesn't exist a consensus about a model for decision making on this matter. In this article a model for decision making is proposed, based on a review of the literature and our own research data. We have attempted to select and classify certain factors which could enable us to arrive at an ethically (...) justifiable method of making a medical decision. In doing so we distinguish two major criteria: heredity and parenting competence, and six minor criteria: conception risk, IQ, age, personality, medical aspects and prognosis and finally support and guidance for the mentally handicapped person. The major criteria give rise to a "situation of necessity". In this situation the physician is confronted with a conflict of values and interests. The minor criteria are of an entirely different ethical order. They can only be considered once the major criteria have created a "situation of necessity". Ultimately it comes down to deciding whether the benefits of sterilisation outweigh the drawbacks and whether the means are appropriate to the end, where efficient contraception is the end and irreversible sterilisation is the means. (shrink)

We describe and analyse how large herbivores strongly diminished a woody vegetation, dominated by the unpalatable shrub Sambucus nigra L. and changed it into grassland. Density of woody species and cover of vegetation were measured in 1996, 2002 and 2012 in the grazed Oostvaardersplassen. In 2002 and 2012 we also measured density and cover in an ungrazed control site. In 2002 we measured intensity of browsing and bark loss of Sambucus shrubs in the grazed and control sites. In the grazed (...) site the density of Sambucus and Salix spp. declined significantly between 1996 and 2012, and large areas changed into grassland. In the control site the density of Sambucus increased significantly during this period, the density of Salix spp. did not change, and the vegetation consisted of a mixture of woody species and a field layer dominated by tall herbs. In 2002 and 2012 the percentages of dead Sambucus shrubs were significantly higher in the grazed site than in the control site. In 2002 the percentages of twigs browsed and ring barked stems of Sambucus shrubs were significantly higher in the grazed site than in the control site. Our results show that debarking caused mature Sambucus shrubs to die, but that heavy browsing may have helped this process. Our results also point to a significant neighbour effect on the break down of Sambucus, suggesting that Aggregational Resistance and Associational Palatability were both active. Essential conditions for the break down of this woody vegetation were the presence of large herbivores, the low ratio between the areas of summer and winter feeding habitats and the competition amongst herbivores. Browsing may have been responsible for seedling death, as seedlings were found only in the control site and not on the old and newly established grasslands in the grazed site. (shrink)

Cognitive Science, Volume 46, Issue 5, May 2022.

A clearly written book by an accomplished teacher. Though obviously published as a textbook, it contains a kind of learning which can only be possessed by a mature philosopher, and perhaps appreciated in full only by a peer. The book is an introduction to philosophy, philosophy broadly and classically conceived, encompassing metaphysics, a theory of knowledge, and philosophical reflections on science, man, nature, and art. The ten chapters devoted to knowledge present to the beginner, simply and lucidly, a review of (...) some of the best work published in the fields of epistemology and the philosophy of science in recent decades. Abel’s approach is both systematic and historical. He allows philosophers to speak to each other across the ages where they have addressed common problems, but the focus is on the problems. His own viewpoint has obviously been shaped by the naturalism of Dewey and Woodbridge, but the book has the merit of being temperate and fair to other fundamentally different metaphysical positions. Throughout his presentation, the philosophical enterprise is seen, not as a critical one of tearing down, but as a collaborative effort in which the best minds of the past, through their various insights, have contributed to the solution of ancient problems relating to man and knowledge. In effect, the book is a refreshing synthesis, and is apt to be far more valuable as a teaching instrument than the usual heterogeneous anthology published for the same purpose.—J.P.D. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:714 BOOK REVIEWS The End of Life. By JAMES RACHELS. Oxford: Oxford University Press, 1986. Pp. 204. The rise of advanced medical technologies, especially life-sustaining ones, has brought to center stage the hioethical issues which arise in acute and long-term care contexts. Especially pressing have been problems about the nature and permissibility of euthanasia. Roughly speaking, there are two major views about euthanasia. The traditional view holds that it (...) is wrong intentionally to kill an innocent human being, hut that, given certain circumstances, it is permissible to withhold or withdraw treatment and allow a patient to die. A more radical view, embraced by groups like the Hemlock Society and the Society for the Right to Die, denies that there is a morally significant distinction between passive and active euthanasia. Further, mercy killing, assisted suicide, and the like are permissible. James Rachels's hook is the most articulate expression of the radical view. The work contains 'ten chapters which can he broken down into l:wo main sections. In chapters one through four, Rachels draws a distinction between what he calls biographical and biological life, and he maintains that, whereas ithe traditional view places emphasis on the latter, the former is what should he considered in euthanasia cases. In chapters five through ten, the distinction between active and passive euthanasia is analyzed. Rachels argues that ithere is no distinction between the two and that euthanasia is permissible in certain circumstances. Chapter one traces the rise of the traditional view in the west from 1the Greeks and Romans to the development of Christanity. According to Rachels, the Greeks and Romans allowed aotive euthanasia-infanticide, suicide-in some cases, because they believed that life held little value apart from the chance of a meaningful or happy existence. But the coming of Christianity caused the traditional doctrine to arise. Until Augustine, the Church taught ·that all killing was wrong. But Christendom during Augustine's time made a politically expedient decision to change its views in 1the face of pressure from the state. The Church adopted the position that all taking of innocent human life was wrong. Two observations should be made here. First, Rachels would have a difficult time proving that the Church changed its views for reasons of political expediency. He makes no attempt to analyze the theological aspects of the situation during Augustine's time, e.g. the shift from a premillenial to an amillenial eschatology with a concomitant change in how the two kingdoms should he related, Second, and more importantly, Rachels discussion of 1the Greeks and Romans contains a serious BOOK REVIEWS 715 omission which is quite revealing in light of later chapters. He does not distinguish happiness and the good life in its formal and material aspects. For many Greek and Roman thinkers, e.g. Aristotle, happiness was more than a mere formal principle. It contained substantive content, viz. the progressive embodiment of intellectual and moral virtues. For Rachels, the good life is whatever an individual finds to be in his own best interests. Chapter.two focuses on the sanctity of life. After surveying eastern views (all life is equally sacred, including that of insects), Rachels criticizes the sanctity-of-life view. As it is expressed in Christianity, this view, as understood by Rachels, holds that all human life is sacred merely because it is biological human life. Being homo sapiens is what gives value to human life. According to Rachels, this is a mistaken understanding of why life is valuable. The sanctity of life should he construed as protecting biographical life, not mere biological life. One's life has value from tlie individual's point of view because he has a biographical life; that is, he can pursue interests and goals that are important to him. The importance of being alive is derivative from the importance of having a life. The traditional view, says Rachels, has lost sight of the point of the rule against killing. H we fail to ask for the purpose of a moral rule, we may sometimes fulfill its letter by going against its spirit. For example, we are taught to drive on,the right side of the road. But if we... (shrink)

Based on the hypotheses that (1) a physiological organization exists inside each activity of daily life and (2) the pattern of evolution of physiological variables is characteristic of each activity, pattern changes should be detected on daily life physiological recordings. The present study aims at investigating whether a simple segmentation method can be set up to detect pattern changes on physiological recordings carried out during daily life. Heart and breathing rates and skin temperature have been non-invasively recorded in volunteers following (...) scenarios made of “daily life” steps (13 records). An observer, undergoing the scenario, wrote down annotations during the recording time. Two segmentation procedures have been compared to the annotations, a visual inspection of the signals and an automatic program based on a trends detection algorithm applied to one physiological signal (skin temperature). The annotations resulted in a total number of 213 segments defined on the 13 records, the best visual inspection detected less segments (120) than the automatic program (194). If evaluated in terms of the number of correspondences between the times marks given by annotations and those resulting from both physiologically based segmentations, the automatic program was better than the visual inspection. The mean time lags between annotation and program time marks remain <60 s (the precision of annotation times marks). We conclude that physiological variables time series recorded in common life conditions exhibit different successive patterns that can be detected by a simple trends detection algorithm. Theses sequences are coherent with the corresponding annotated activity. (shrink)

For anyone who teaches the philosophy of law this is an indispensible volume. Currie's intent is to provide a critical history of the Court's constitutional work for the first hundred years. In writing that history he displays the multiple methods of constitutional analysis and the techniques of opinion writing employed under seven Supreme Court justices. Not surprisingly, he concludes that judicial performance is not uniform. Currie makes no attempt to hide the vantage point from which he is writing. He assumes (...) that the Constitution is a law binding the judges no less than the other officials whose action the Court undertakes to review. He flatly states his conviction that judges have no right to ignore those constitutional limitations with which they disagree and adds that when Congress has acted within the powers granted by the Constitution, it is not for the Court to interfere. The same is true for state laws that do not offend the Constitution. "It follows," says Currie, "that the judges have no more right to invent limitations not found in the Constitution than to disregard those put there by the Framers. In short, when a judge swears to uphold the Constitution, he promises obedience to a set of rules laid down by someone else.". (shrink)

NIK1 is a receptor‐like kinase involved in plant antiviral immunity. Although NIK1 is structurally similar to the plant immune factor BAK1, which is a key regulator in plant immunity to bacterial pathogens, the NIK1‐mediated defenses do not resemble BAK1 signaling cascades. The underlying mechanism for NIK1 antiviral immunity has recently been uncovered. NIK1 activation mediates the translocation of RPL10 to the nucleus, where it interacts with LIMYB to fully down‐regulate translational machinery genes, resulting in translation inhibition of host and viral (...) mRNAs and enhanced tolerance to begomovirus. Therefore, the NIK1 antiviral immunity response culminates in global translation suppression, which represents a new paradigm for plant antiviral defenses. Interestingly, transcriptomic analyses in nik1 mutant suggest that NIK1 may suppress antibacterial immune responses, indicating a possible opposite effect of NIK1 in bacterial and viral infections. (shrink)

BackgroundKinarm Standard Tests is a suite of upper limb tasks to assess sensory, motor, and cognitive functions, which produces granular performance data that reflect spatial and temporal aspects of behavior. We have previously used principal component analysis to reduce the dimensionality of multivariate data using the Kinarm End-Point Lab. Here, we performed PCA using data from the Kinarm Exoskeleton Lab, and determined agreement of PCA results across EP and EXO platforms in healthy participants. We additionally examined whether further dimensionality reduction (...) was possible by using PCA across behavioral tasks.MethodsHealthy participants were assessed using the Kinarm EXO and EP. Four behavioral tasks were performed that quantified arm sensory and motor function, including position sense [Arm Position Matching ] and three motor tasks [Visually Guided Reaching, Object Hit, and Object Hit and Avoid ]. The number of components to include per task was determined from scree plots and parallel analysis, and rotation type was decided on a per-task basis. To assess agreement, we compared principal components across platforms using distance correlation. We additionally considered inter-task interactions in EXO data by performing PCA across all six behavioral assessments.ResultsBy applying PCA on a per task basis to data collected using the EXO, the number of behavioral parameters were substantially reduced by 58–75% while accounting for 76–87% of the variance. These results compared well to the EP analysis, and we found good-to-excellent agreement values between PCs from the EXO and those from the EP. Finally, we were able to reduce the dimensionality of the EXO data across tasks down to 16 components out of a total of 76 behavioral parameters, which represents a reduction of 79% while accounting for 73% of the total variance.ConclusionPCA of Kinarm robotic assessment appears to capture similar relationships between kinematic features in healthy individuals and is agnostic to the robotic platform used for collection. Further work is needed to investigate the use of PCA-based data reduction for the characterization of neurological deficits in clinical populations. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Interpreting Arnauld ed. by Elmar J. KremerLisa DowningElmar J. Kremer, editor. Interpreting Arnauld. Toronto: University of Toronto Press, 1996. Pp. xi + 183. Cloth, $65.00.This attractive volume represents (with one exception) the proceedings of what was evidently a lively colloquium on Arnauld’s philosophy, held at the University of Toronto in 1994 to commemorate the three-hundredth anniversary of his death. Although Antoine Arnauld has been best known to contemporary (...) philosophers as the author of the fourth set of objections to Descartes’ Meditations, interest in Arnauld’s own philosophical thought appears to be on the rise within the Anglo-American philosophical community, as indicated by the publication, within the last eight years, of two new translations of his Des vrayes et des fausses idées (a philosophical polemic against Malebranche) and a new translation of the Port-Royal Logic that Arnauld co-authored with Pierre Nicole. This new collection, from an international group of contributors, is thus well-timed. The two main themes that emerge from the collection as a whole serve to indicate the potential importance of Arnauld scholarship to our understanding of seventeenth century philosophy.The first theme that unites most of the papers is that of the diversity of views that existed within the constellation of philosophers who identified in one way or another with the doctrines of René Descartes. Arnauld was, of course, one such Cartesian. Nevertheless, many of the papers take the differences between Descartes and Arnauld as their starting point. Peter Schouls sets up a general contrast between the modernity of Descartes’ thought, as founded on the validity of subjective consciousness, and the tradition-grounded character of Arnauld’s philosophy. Jill Vance Buroker focuses productively on Arnauld’s and Descartes’ opposing views on the nature of assertion and judgment. Alan Nelson uses Arnauld’s challenge to Descartes’ account of the material falsity of ideas as the basis for a controversial but fascinating reassessment of a range of crucial issues in Descartes scholarship: clarity and distinctness, objective reality, and representation, as well as material falsity. Jean-Luc Solère’s contribution (described further below) documents the fact that significant philosophical debates existed, not [End Page 367] just within Cartesianism, but even within the still narrower Jansenist community that agreed in taking Augustine and Descartes as their philosophical models. In thus highlighting and documenting the diversity and richness of Cartesianism, the collection provides a valuable contribution to the history of philosophy. This theme is also very much present in the essays by Ndiaye, Kremer, and Carraud, which are discussed below.The second theme, shared by the majority of the papers, is that of philosophical theology. As Elmar Kremer remarks in his editor’s introduction (p. ix), while Arnauld himself held that philosophy and theology are distinguishable disciplines, the volume as a whole documents their many interconnections in his work. These interconnections are especially well brought out in the contributions by Kremer, Solère, and Sleigh. Kremer argues that we can understand three of Arnauld’s key departures from Descartes (with respect to the nature of body, the production of sensory ideas, and divine omnipotence) as motivated by his Christian commitments. Solère contends, in his intricate and illuminating essay, that Arnauld’s views about the metaphysical status of known truths (that they are relations in our minds, rather than entities in God grasped by us) are connected to a debate about the savability of non-Christians, and that his disputant, Pierre Nicole, developed an account of implicit or indirect knowledge in order to accommodate his commitment to general grace, a divine illumination had by everyone. Robert Sleigh’s essay considers the difficult question of how Arnauld wished to reconcile his doctrine of efficacious grace with human freedom: Arnauld clearly advocated some sort of compatibilism, but what sort, exactly? Although Sleigh admits that he cannot give an unambiguous defense of a single answer, his map of the territory is very valuable indeed. Other topics in philosophical theology touched on in the collection are the epistemology of papal infallibility (discussed by Thomas Lennon), miracles (discussed by Graeme Hunter) and divine omnipotence. This last topic (which is connected both to the question of the... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Interpreting Arnauld ed. by Elmar J. KremerLisa DowningElmar J. Kremer, editor. Interpreting Arnauld. Toronto: University of Toronto Press, 1996. Pp. xi + 183. Cloth, $65.00.This attractive volume represents (with one exception) the proceedings of what was evidently a lively colloquium on Arnauld’s philosophy, held at the University of Toronto in 1994 to commemorate the three-hundredth anniversary of his death. Although Antoine Arnauld has been best known to contemporary (...) philosophers as the author of the fourth set of objections to Descartes’ Meditations, interest in Arnauld’s own philosophical thought appears to be on the rise within the Anglo-American philosophical community, as indicated by the publication, within the last eight years, of two new translations of his Des vrayes et des fausses idées (a philosophical polemic against Malebranche) and a new translation of the Port-Royal Logic that Arnauld co-authored with Pierre Nicole. This new collection, from an international group of contributors, is thus well-timed. The two main themes that emerge from the collection as a whole serve to indicate the potential importance of Arnauld scholarship to our understanding of seventeenth century philosophy.The first theme that unites most of the papers is that of the diversity of views that existed within the constellation of philosophers who identified in one way or another with the doctrines of René Descartes. Arnauld was, of course, one such Cartesian. Nevertheless, many of the papers take the differences between Descartes and Arnauld as their starting point. Peter Schouls sets up a general contrast between the modernity of Descartes’ thought, as founded on the validity of subjective consciousness, and the tradition-grounded character of Arnauld’s philosophy. Jill Vance Buroker focuses productively on Arnauld’s and Descartes’ opposing views on the nature of assertion and judgment. Alan Nelson uses Arnauld’s challenge to Descartes’ account of the material falsity of ideas as the basis for a controversial but fascinating reassessment of a range of crucial issues in Descartes scholarship: clarity and distinctness, objective reality, and representation, as well as material falsity. Jean-Luc Solère’s contribution (described further below) documents the fact that significant philosophical debates existed, not [End Page 367] just within Cartesianism, but even within the still narrower Jansenist community that agreed in taking Augustine and Descartes as their philosophical models. In thus highlighting and documenting the diversity and richness of Cartesianism, the collection provides a valuable contribution to the history of philosophy. This theme is also very much present in the essays by Ndiaye, Kremer, and Carraud, which are discussed below.The second theme, shared by the majority of the papers, is that of philosophical theology. As Elmar Kremer remarks in his editor’s introduction (p. ix), while Arnauld himself held that philosophy and theology are distinguishable disciplines, the volume as a whole documents their many interconnections in his work. These interconnections are especially well brought out in the contributions by Kremer, Solère, and Sleigh. Kremer argues that we can understand three of Arnauld’s key departures from Descartes (with respect to the nature of body, the production of sensory ideas, and divine omnipotence) as motivated by his Christian commitments. Solère contends, in his intricate and illuminating essay, that Arnauld’s views about the metaphysical status of known truths (that they are relations in our minds, rather than entities in God grasped by us) are connected to a debate about the savability of non-Christians, and that his disputant, Pierre Nicole, developed an account of implicit or indirect knowledge in order to accommodate his commitment to general grace, a divine illumination had by everyone. Robert Sleigh’s essay considers the difficult question of how Arnauld wished to reconcile his doctrine of efficacious grace with human freedom: Arnauld clearly advocated some sort of compatibilism, but what sort, exactly? Although Sleigh admits that he cannot give an unambiguous defense of a single answer, his map of the territory is very valuable indeed. Other topics in philosophical theology touched on in the collection are the epistemology of papal infallibility (discussed by Thomas Lennon), miracles (discussed by Graeme Hunter) and divine omnipotence. This last topic (which is connected both to the question of the... (shrink)

K. J. Dover, in Greek Homosexuality , p. 125 n. 1, observes: ‘My interpretation ad loc. , that drosos is Cowper's secretion, appearing when the boy's penis has been erected by titillation, is far-fetched , but no other interpretation so far seems to me to pay enough attention to the semantics of drosos or to explain why Right regards the beauty of “drosos and down” as incompatible with anointing below the navel’.

K. J. Dover, in Greek Homosexuality, p. 125 n. 1, observes: ‘My interpretation ad loc., that drosos is Cowper's secretion, appearing when the boy's penis has been erected by titillation, is far-fetched, but no other interpretation so far seems to me to pay enough attention to the semantics of drosos or to explain why Right regards the beauty of “drosos and down” as incompatible with anointing below the navel’.

J. Kaerst, following a suggestion made by Ranke, conjectured that Diodorus' source for Alexander, whom he identified with Clitarchus, derived information from the mercenaries who served Darius. This conjecture has been developed into an elaborate theory by Sir William Tarn, a theory that has found some favour. He holds that the ‘mercenaries' source’, which I shall henceforth call M, was Diodorus' ‘principal guide [my italics] down to Issus’, and also ‘largely used’ by Curtius ; from certain texts in Curtius Tarn (...) infers that M went down to Darius' death, and he thinks that till that point both Diodorus and Curtius continued to draw upon him, as well as upon other authorities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Interpreting Arnauld ed. by Elmar J. KremerLisa DowningElmar J. Kremer, editor. Interpreting Arnauld. Toronto: University of Toronto Press, 1996. Pp. xi + 183. Cloth, $65.00.This attractive volume represents (with one exception) the proceedings of what was evidently a lively colloquium on Arnauld’s philosophy, held at the University of Toronto in 1994 to commemorate the three-hundredth anniversary of his death. Although Antoine Arnauld has been best known to contemporary (...) philosophers as the author of the fourth set of objections to Descartes’ Meditations, interest in Arnauld’s own philosophical thought appears to be on the rise within the Anglo-American philosophical community, as indicated by the publication, within the last eight years, of two new translations of his Des vrayes et des fausses idées (a philosophical polemic against Malebranche) and a new translation of the Port-Royal Logic that Arnauld co-authored with Pierre Nicole. This new collection, from an international group of contributors, is thus well-timed. The two main themes that emerge from the collection as a whole serve to indicate the potential importance of Arnauld scholarship to our understanding of seventeenth century philosophy.The first theme that unites most of the papers is that of the diversity of views that existed within the constellation of philosophers who identified in one way or another with the doctrines of René Descartes. Arnauld was, of course, one such Cartesian. Nevertheless, many of the papers take the differences between Descartes and Arnauld as their starting point. Peter Schouls sets up a general contrast between the modernity of Descartes’ thought, as founded on the validity of subjective consciousness, and the tradition-grounded character of Arnauld’s philosophy. Jill Vance Buroker focuses productively on Arnauld’s and Descartes’ opposing views on the nature of assertion and judgment. Alan Nelson uses Arnauld’s challenge to Descartes’ account of the material falsity of ideas as the basis for a controversial but fascinating reassessment of a range of crucial issues in Descartes scholarship: clarity and distinctness, objective reality, and representation, as well as material falsity. Jean-Luc Solère’s contribution (described further below) documents the fact that significant philosophical debates existed, not [End Page 367] just within Cartesianism, but even within the still narrower Jansenist community that agreed in taking Augustine and Descartes as their philosophical models. In thus highlighting and documenting the diversity and richness of Cartesianism, the collection provides a valuable contribution to the history of philosophy. This theme is also very much present in the essays by Ndiaye, Kremer, and Carraud, which are discussed below.The second theme, shared by the majority of the papers, is that of philosophical theology. As Elmar Kremer remarks in his editor’s introduction (p. ix), while Arnauld himself held that philosophy and theology are distinguishable disciplines, the volume as a whole documents their many interconnections in his work. These interconnections are especially well brought out in the contributions by Kremer, Solère, and Sleigh. Kremer argues that we can understand three of Arnauld’s key departures from Descartes (with respect to the nature of body, the production of sensory ideas, and divine omnipotence) as motivated by his Christian commitments. Solère contends, in his intricate and illuminating essay, that Arnauld’s views about the metaphysical status of known truths (that they are relations in our minds, rather than entities in God grasped by us) are connected to a debate about the savability of non-Christians, and that his disputant, Pierre Nicole, developed an account of implicit or indirect knowledge in order to accommodate his commitment to general grace, a divine illumination had by everyone. Robert Sleigh’s essay considers the difficult question of how Arnauld wished to reconcile his doctrine of efficacious grace with human freedom: Arnauld clearly advocated some sort of compatibilism, but what sort, exactly? Although Sleigh admits that he cannot give an unambiguous defense of a single answer, his map of the territory is very valuable indeed. Other topics in philosophical theology touched on in the collection are the epistemology of papal infallibility (discussed by Thomas Lennon), miracles (discussed by Graeme Hunter) and divine omnipotence. This last topic (which is connected both to the question of the... (shrink)

According to Jones & Love (J&L), Bayesian theories are too often isolated from other theories and behavioral processes. Here, we highlight examples of two types of isolation from the field of word learning. Specifically, Bayesian theories ignore emergence, critical to development theory, and have not probed the behavioral details of several key phenomena, such as the effect.

Critics comment on the simplicity of the jest here, not without reason.1 But the levity also has some sophistication, of a literary kind. For a start,andare aptly long and are carefully left to the end of their clauses and lines for maximum effect. In addition, these striking words, which appear for the first time in Sappho, may well have been deliberate adaptations of two adjectives which had previously occurred only in Homer,2 and they would in any case have called to (...) mind the Homeric ones, because of their close similarity and because there are no other variants of these compounds in surviving literature down to the time of the j poetess.3 At Odyssey11.312 the poet had said of Otus and Ephialtes and at Iliad 7.220, 222, 245, 266 and 11.545 he had described the shield of Ajax asSo, given the epic flavour of Sappho′s epithets, it was amusing of her to include them at all in such a light and frivolous context. There is also pawkiness in the poetess′s application of these terms I with their Homeric tinge to quite different and very mundane objects; and the humour is increased when one takes into account the associations that these words had .This strikes me as an early instance of witty adaptation of epic diction such as is found in Anacreon 358 and 417 PMG.4. (shrink)

Even though integrity is widely considered to be an essential aspect of research, there is an ongoing debate on what actually constitutes research integrity. The understanding of integrity ranges from the minimal, only considering falsification, fabrication and plagiarism, to the maximum, blending into science ethics. Underneath these obvious contrasts, there are more subtle differences that are not as immediately evident. The debate about integrity is usually presented as a single, universal discussion, with shared concerns for researchers, policymakers and ‘the public’. (...) In this article, we show that it is not. There are substantial differences between the language of research integrity in the scientific arena and in the public domain. Notably, scientists and policymakers adopt different approaches to research integrity. Scientists tend to present integrity as a virtue that must be kindled, while policy documents and newspapers stress norm enforcement. Rather than performing a conceptual analysis through philosophical reasoning and discussion, we aimed to clarify the discourse of ‘scientific integrity’ by studying its usage in written documents. To this end, large numbers of scientific publications, policy documents and newspaper articles were analysed by means of scientometric and content analysis techniques. The texts were analysed on their usage of the term ‘integrity’ and of frequently co-occurring terms and concepts. A comparison was made between the usage in the various media, as well as between different periods in which they were published through co-word analysis, mapping co-occurrence networks of significant terms and themes. (shrink)

Human migration is nonrandom. In small scale societies of the past, and in the modern world, people tend to move to wealthier, safer, and more just societies from poorer, more violent, less just societies. If immigrants are assimilated, such nonrandom migration can increase the occurrence of culturally transmitted beliefs, values, and institutions that cause societies to be attractive to immigrants. Here we describe and analyze a simple model of this process. This model suggests that long run outcomes depend on the (...) relative strength of migration and local adaptation. When local adaption is strong enough to preserve cultural variation among groups, cultural variants that make societies attractive always predominate, but never drive alternative variants to extinction. When migration predominates, outcomes depend both on the relative attractiveness of alternative variants and on the initial sizes of societies that provide and receive immigrants. (shrink)

We introduce a linear analogue of Läuchli's semantics for intuitionistic logic. In fact, our result is a strengthening of Läuchli's work to the level of proofs, rather than provability. This is obtained by considering continuous actions of the additive group of integers on a category of topological vector spaces. The semantics, based on functorial polymorphism, consists of dinatural transformations which are equivariant with respect to all such actions. Such dinatural transformations are called uniform. To any sequent in Multiplicative Linear Logic (...) , we associate a vector space of“diadditive” uniform transformations. We then show that this space is generated by denotations of cut-free proofs of the sequent in the theory MLL + MIX. Thus we obtain a full completeness theorem in the sense of Abramsky and Jagadeesan, although our result differs from theirs in the use of dinatural transformations.As corollaries, we show that these dinatural transformations compose, and obtain a conservativity result: diadditive dinatural transformations which are uniform with respect to actions of the additive group of integers are also uniform with respect to the actions of arbitrary cocommutative Hopf algebras. Finally, we discuss several possible extensions of this work to noncommutative logic.It is well known that the intuitionistic version of Läuchli's semantics is a special case of the theory of logical relations, due to Plotkin and Statman. Thus, our work can also be viewed as a first step towards developing a theory of logical relations for linear logic and concurrency. (shrink)

In his ‘On t and u and what they can do’, Greg Restall presents an apparent problem for a handful of well-known non-classical solutions to paradoxes like the liar. In this article, we argue that there is a problem only if classical logic – or classical-enough logic – is presupposed. 1. Background Many have thought that invoking non-classical logic – in particular, a paracomplete or paraconsistent logic – is the correct response to the liar and related paradoxes. At the most (...) basic level, the target non-classical idea is that some expressions, like ‘all and only the true propositions’, do not behave as we would expect from classical logic. Non-classical theorists argue that the class of all and only the truths is either incomplete or inconsistent: when you truly speak of all and only truths , you're either leaving some truths out, or you're letting some untruths in. Truth, in a slogan, is either gappy or glutty. Non-classicality is not a glib or easy-way-out response to the paradoxes. Innocuous-seeming notions can turn out to be philosophically substantial. Moreover, apparently correct forms of reasoning can turn out to be incorrect. To take a example, a glut theorist must hold that the following argument form is not in general valid. Either p is true or q is true. But p is untrue. So q is true. This argument form may strike our ears as acceptable. But if p is a truth value glut, then the inference fails to preserve truth. According to glut theorists, the inference breaks down in inconsistent contexts: if the subject matter involves gluts, then the inference is to be rejected. And the liar paradox, according to such theorists, shows that truth is exactly the kind of subject matter that yields inconsistency. In the …. (shrink)

Following publication of this article [1] it was brought to our attention that we omitted to provide credit for Table 1. While the content of the table and the systematization of blinding in review have been referenced in the text as coming from [2], the credit line for Table 1 should have been added as follows: “Reproduced with permission from [2] licensed under a CC BY-NC-ND 3.0 License”. The original publication of this article has been corrected accordingly.

James Stacey Taylor urges academics to become qualitatively better at what we do in terms of scholarship. For while it will inevitably slow down our rush to publish our work for financial or careerist gains, the quality of published research will improve significantly as a result.In Part I, Taylor focuses on some details of a few salient philosophical discussions concerning the moral limits of markets, including the discussion of the Asymmetry Thesis—that there are some things that can legitimately be given (...) away, but which it would necessarily be wrongful to buy or sell—and how, among others, Michael Sandel's, Debra Satz's, and Elizabeth Anderson's respective works in the field have been misunderstood due to poor scholarship. This mis-ascription has caused confusion in the philosophical literature on markets and morals. As a result, Taylor argues, some scholars misattribute to these authors a view which ‘almost nobody holds’ (p. 29).In Part II, Taylor seeks to remedy the problem of poor scholarship as it ‘derails’ productive philosophical discussion: Higher educational research ought not to answer to market demands, but instead ought to answer to academic ones. (shrink)

The European Clinical Trials Directive was issued in 2001 and aimed to simplify and harmonise the regulatory framework of clinical trials throughout Europe, thus stimulating European research. However, significant complexity and inconsistency remains due to disparate interpretation by EU member states. Critical care research has been particularly impacted due to variable and often restrictive consenting procedures for incapacitated subjects, with some countries requiring a court-appointed representative, while others recognise consent from family members and occasionally professional representatives. Furthermore, the absence of (...) a waiver of consent threatened to put an end to emergency research in Europe and was met with varied responses. Approval procedures by ethics committees are equally inconsistent, particularly those relating to provision of a single opinion for multi-centre trials. Although evidence is somewhat mixed, this complexity as well as a general increase in administrative and financial burden following the Directive has been shown to cause a reduction in clinical trial activity in Europe, particularly academic trials. We aim to clarify some of these inconsistent procedures, particularly those relating to informed consent of incapacitated subjects, as well as discussing some general weaknesses and possible improvements of the Directive ahead of its planned revision in 2011. (shrink)