For almost 30 years the ion channel that initiates the ON visual pathway in vertebrate vision has remained elusive. Recent findings now indicate that the pathway, which begins with unbinding of glutamate from the metabotropic glutamate receptor 6 (mGluR6), ends with the opening of the transient receptor potential (TRP)M1 cation channel. As a component of the mGluR6 signal transduction pathway, mutations in TRPM1 would be expected to cause congenital stationary night blindness (CSNB), and several such mutations have already been identified (...) in CSNB families. Furthermore, expression of TRPM1 in both the retina and skin raises the possibility that a genetic link exists between certain types of visual and skin disorders. (shrink)

The French medical context is characterized by institutionalization of the ethical reflection in health care facilities and an important disparity between spaces of ethical reflection. In theory, the healthcare professional may mobilise an arsenal of resources to help him in his ethical reflection. But what happens in practice? We conducted semi-structured interviews with 22 health-care professionals who did and did not have recourse to clinical ethical committees. We also implemented two focus groups with 18 professionals involved in various spaces of (...) ethical reflection in order to let them debate about a better way to organize ethical reflection in their institutional contexts. The qualitative analysis allows to us to underline the coexistence of different conceptions of ethics among health care professionals. We also observed that the participants in our study shared the experience of ethically problematic situations as roadblocks in the process of communication and decision-making. We therefore report the factors which favour or inhibit the ethical course leading to the resolution or at the very least soothing of the situation at hand. Finally, we discuss methodological issues and underline the fact that while the patient is at the heart of the professional’s ethical preoccupations, this does not imply that they are actors in decisions that concern them. (shrink)

Recent studies claim that having an analytical cognitive style is correlated with reduced religiosity in western populations. However, in cultural contexts where social norms constrain behavior, such cognitive characteristics may have reduced influence on behaviors and beliefs. We labeled this the ‘constraining environments hypothesis.’ In a sample of 246 Muslims in Turkey, the hypothesis was supported for gender. Females face social pressure to be religious. Unlike their male counterparts, they were more religious, less analytical, and their analytical scores were uncorrelated (...) with religiosity. We had predicted an analogous effect for the comparison between monolingual and bilingual students, since English-proficient students are exposed to a wider social environment. The bilingual students were less religious than the monolingual students, yet they were also less analytical. Thus, being analytical was not the path to lower religiosity for the bilingual students. Cognitive styles need to be studied along with social norms in a variety of cultures, to understand religion-cognition relationships. (shrink)

The progression of research and scholarly inquiry does not occur in isolation and is wholly dependent on accurate reporting of methods and results, and successful replication of prior work. Without mechanisms to correct the literature, much time and money is wasted on research based on a crumbling foundation. These guidelines serve to outline the respective responsibilities of researchers, institutions, agencies, and publishers or editors in maintaining the integrity of the research record. Delineating these complementary roles and proposing solutions for common (...) barriers provide a foundation for best practices. (shrink)

In the past decade, the cognitive science of religion has worked to find an evolutionary explanation for supernatural belief. The explanations are convincing, but have created the stereotype that atheism is unnatural. In a similar way studies linking religious belief and health have vilified atheism as unhealthy. But belief is too complex, health is too nuanced, and the data are too varied to draw such a generalization. Catherine Caldwell-Harris has developed a psychological profile to understand nonbelief as an expected (...) outcome of individual difference and therefore natural. In a similar manner I argue that we should study the relationship between belief and health through the lens of individual differences. This approach is especially promising given recent research which indicates personality fully accounts for the relationship with well-being previously attributed to belief. This approach has the added benefit of neutralizing the conversation by understanding atheism as the healthy expression of a natural personality. (shrink)

In the seventeenth century the microscope opened up a new world of observation, and, according to Catherine Wilson, profoundly revised the thinking of scientists and philosophers alike. The interior of nature, once closed off to both sympathetic intuition and direct perception, was now accessible with the help of optical instruments. The microscope led to a conception of science as an objective, procedure-driven mode of inquiry and renewed interest in atomism and mechanism. Focusing on the earliest forays into microscopical research, (...) from 1620 to 1720, this book provides us with both a compelling technological history and a lively assessment of the new knowledge that helped launch philosophy into the modern era. Wilson argues that the discovery of the microworld--and the apparent role of living animalcula in generation, contagion, and disease--presented metaphysicians with the task of reconciling the ubiquity of life with human-centered theological systems. It was also a source of problems for philosophers concerned with essences, qualities, and the limits of human knowledge, whose positions are echoed in current debates about realism and instrument-mediated knowledge. Covering the contributions of pioneering microscopists (Leeuwenhoek, Swammerdam, Malpighi, Grew, and Hooke) and the work of philosophers interested in the microworld (Bacon, Descartes, Leibniz, Malebranche, Locke, and Berkeley), she challenges historians who view the abstract sciences as the sole catalyst of the Scientific Revolution as she stresses the importance of observational and experimental science to the modern intellect. (shrink)

Is contemporary continental philosophy making a break with Kant? The structures of knowledge, taken for granted since Kants Critique of Pure Reason, are now being called into question: the finitude of the subject, the phenomenal given, a priori synthesis. Relinquish the transcendental: such is the imperative of postcritical thinking in the 21st century. Questions that we no longer thought it possible to ask now reemerge with renewed vigor: can Kant really maintain the difference between a priori and innate? Can he (...) deduce, rather than impose, the categories, or justify the necessity of nature? Recent research into brain development aggravates these suspicions, which measure transcendental idealism against the thesis of a biological origin for cognitive processes. In her important new book Catherine Malabou lays out Kants response to his posterity. True to its subject, the book evolves as an epigenesis – the differentiated growth of the embryo – for, as those who know how to read critical philosophy affirm, this is the very life of the transcendental and contains the promise of its transformation. (shrink)

This book is one of the most important recent books on Hegel, a philosopher who has had a crucial impact on the shape of continental philosophy. Published here in English for the first time, it includes a substantial preface by Jacques Derrida in which he explores the themes and conclusions of Malabou's book. _The Future of Hegel: Plasticity, Temporality and Dialectic_ restores Hegel's rich and complex concepts of time and temporality to contemporary philosophy. It examines his concept of time, relating (...) it to perennial topics in philosophy such as substance, accident and the identity of the subject. Catherine Malabou's also contrasts her account of Hegelian temporality with the interpretation given by Heidegger in _Being and Time_, arguing that it is the concept of 'plasticity' that best describes Hegel's theory of temporality. The future is understood not simply as a moment in time, but as something malleable and constantly open to change through our interpretation. The book also develops Hegel's preoccupation with the history of Greek thought and Christianity and explores the role of theology in his thought. Essential reading for those interested in Hegel and contemporary continental philosophy, _The Future of Hegel _is also fascinating to those interested in the ideas of Heidegger and Derrida. (shrink)

Is it possible to apply a theoretical approach to ethics? The French philosopher Catherine Chalier addresses this question with an unusual combination of traditional ethics and continental philosophy. In a powerful argument for the necessity of moral reflection, Chalier counters the notion that morality can be derived from theoretical knowledge. Chalier analyzes the positions of two great moral philosophers, Kant and Levinas. While both are critical of an ethics founded on knowledge, their criticisms spring from distinctly different points of (...) view. Chalier reexamines their conclusions, pitting Levinas against (and with) Kant, to interrogate the very foundations of moral philosophy and moral imperatives. She provides a clear, systematic comparison of their positions on essential ideas such as free will, happiness, freedom, and evil. Although based on a close and elegant presentation of Kant and Levinas, Chalier's book serves as a context for the development of the author's own reflections on the question "What am I supposed to do?" and its continued importance for contemporary philosophy. (shrink)

A conspicuous feature of contemporary modelling practices is the use of the same mathematical forms and modelling methods across different scientific domains. This model transfer raises many philosophical questions concerning, for example, the exact object of transfer, the relationship between the model and the target domain, the specific challenges such transfer confronts, and the ways in which model transfer relates to scientific progress. While the interest in studying model transfer has increased among philosophers of science in recent years, the phenomenon (...) has not yet received its due attention. The literature is scattered and much of it has addressed questions around the factors that might explain model transfer, such as whether the different target phenomena to which a model is applied eventually prove to be structurally and dynamically similar, or whether they have to share more fundamental ontological features that explain the interdisciplinary success of distinct models. This chapter surveys the existing literature on model transfer with the main goal of highlighting the main findings of existing discussions and pointing out open issues whose discussion would improve our understanding of this highly relevant phenomenon in science. (shrink)

In this chapter, it is described and assessed how political scientists use rational choice theories to offer causal explanations. We observe that the ways in which rational choice theories are considered to be successful in political science differs, depending on the explanandum in question. Political scientists use empirical variants of rational choice theories to explain the political behavior of individual agents and analytical variants to explain the behavior of collective actors. Both variants are used for distinct explananda, which ask for (...) different modes of explanation that raise in turn different explanatory demands toward rational choice theories. We argue that when political scientists discuss the explanatory usefulness of rational choice theories, they should assess them in light of the demands they are supposed to meet. This would enable a more nuanced and problem-oriented appraisal of rational choice theories in political science. (shrink)

In the last decade, the organization of pharmaceutical research on neglected tropical diseases has undergone transformative change. In a context of perceived “market failure,” the development of new medicines is increasingly handled by public-private partnerships. This shift toward hybrid organizational models depends on a particular form of exchange: the sharing of proprietary assets in general and of intellectual property rights in particular. This article explores the paradoxical role of private property in this new configuration of global health research and development. (...) Rather than a tool to block potential competitors, proprietary assets function as a lever to attract others into risky collaborative ventures; instead of demarcating public and private domains, the sharing of property rights is used to increase the porosity of that boundary. This reimagination of the value of property is connected to the peculiar timescape of global health drug development, a promissory orientation to the future that takes its clearest form in the centrality of “virtual” business models and the proliferation of strategies of deferral. Drawing on the anthropological literature on inalienable possessions, we reconsider property’s traditional exclusionary role and discuss the possibility that the new pharmaceutical “commons” proclaimed by contemporary global health partnerships might be the precursor of future enclosures. (shrink)

This article traces a normative turn between the middle of the 1940s and the early 1950s reflected in the reformulation, interpretation, and use of rational choice theories at the Cowles Commission for Research in Economics. This turn is paralleled by a transition from Jacob Marschak’s to Tjalling Koopmans’s research program. While rational choice theories initially raised high hopes that they would serve as empirical accounts to inform testable hypotheses about economic regularities, they became increasingly modified and interpreted as normative approaches (...) offering behavioral recommendations for individual agents, organizations, government, and teams. The predefined elements constitutive of these accounts, inspired by simple rules of logic, were now meant to represent the basic demands of rationality and theories of rational decision making specified rules of conduct that were meant to shape rather than explain behavior. (shrink)

Epicureanism is commonly associated with a carefree view of life and the pursuit of pleasures, particularly the pleasures of the table. However it was a complex and distinctive system of philosophy that emphasized simplicity and moderation, and considered nature to consist of atoms and the void. Epicureanism is a school of thought whose legacy continues to reverberate today.In this Very Short Introduction, Catherine Wilson explains the key ideas of the School, comparing them with those of the rival Stoics and (...) with Kantian ethics, and tracing their influence on the development of scientific and political thought from Locke, Newton, and Galileo to Rousseau, Marx, Bentham, and Mill. She discusses the adoption and adaptation of Epicurean motifs in science, morality, and politics from the 17th Century onwards and contextualises the significance of Epicureanism in modern life. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable. (shrink)

Issues of balancing data accessibility with ethical considerations and governance of a genomics research biobank, Generation Scotland, are explored within the evolving policy landscape of the past ten years. During this time data sharing and open data access have become increasingly important topics in biomedical research. Decisions around data access are influenced by local arrangements for governance and practices such as linkage to health records, and the global through policies for biobanking and the sharing of data with large-scale biomedical research (...) data resources and consortia. We use a literature review of policy relevant documents which apply to the conduct of biobanks in two areas: support for open access and the protection of data subjects and researchers managing a bioresource. We present examples of decision making within a biobank based upon observations of the Generation Scotland Access Committee. We reflect upon how the drive towards open access raises ethical dilemmas for established biorepositories containing data and samples from human subjects. Despite much discussion in science policy literature about standardisation, the contextual aspects of biobanking are often overlooked. Using our engagement with GS we demonstrate the importance of local arrangements in the creation of a responsive ethical approach to biorepository governance. We argue that governance decisions regarding access to the biobank are intertwined with considerations about maintenance and viability at the local level. We show that in addition to the focus upon ever more universal and standardised practices, the local expertise gained in the management of such repositories must be supported. A commitment to open access in genomics research has found almost universal backing in science and health policy circles, but repositories of data and samples from human subjects may have to operate under managed access, to protect privacy, align with participant consent and ensure that the resource can be managed in a sustainable way. Data access committees need to be reflexive and flexible, to cope with changing technology and opportunities and threats from the wider data sharing environment. To understand these interactions also involves nurturing what is particular about the biobank in its local context. (shrink)

Although interest in the subject of human-resource marketing is growing among researchers and practitioners, there have been remarkably few studies on the effects on employees of how benevolent their organization is. This article looks at the link between the presumption of organizational benevolence and the well-being of employees at work. The results of an empirical study of 595 employees show that the presumption of organizational benevolence is positively linked to employee well-being. The effect is indirect, as it is mediated by (...) the perceived level of organizational support. The existence of a link between employee well-being and intention to quit the company is also confirmed. (shrink)

Philosophical investigation in synthetic biology has focused on the knowledge-seeking questions pursued, the kind of engineering techniques used, and on the ethical impact of the products produced. However, little work has been done to investigate the processes by which these epistemological, metaphysical, and ethical forms of inquiry arise in the course of synthetic biology research. An attempt at this work relying on a particular area of synthetic biology will be the aim of this chapter. I focus on the reengineering of (...) metabolic pathways through the manipulation and construction of small DNA-based devices and systems synthetic biology. Rather than focusing on the engineered products or ethical principles that result, I will investigate the processes by which these arise. As such, the attention will be directed to the activities of practitioners, their manipulation of tools, and the use they make of techniques to construct new metabolic devices. Using a science-in-practice approach, I investigate problems at the intersection of science, philosophy of science, and sociology of science. I consider how practitioners within this area of synthetic biology reconfigure biological understanding and ethical categories through active modelling and manipulation of known functional parts, biological pathways for use in the design of microbial machines to solve problems in medicine, technology, and the environment. We might describe this kind of problem-solving as relying on what Helen Longino referred to as “social cognition” or the type of scientific work done within what Hasok Chang calls “systems of practice”. My aim in this chapter will be to investigate the relationship that holds between systems of practice within metabolic engineering research and social cognition. I will attempt to show how knowledge and normative valuation are generated from this particular network of practitioners. In doing so, I suggest that the social nature of scientific inquiry is ineliminable to both knowledge acquisition and ethical evaluations. (shrink)

Counterpath is a collaborative work by Catherine Malabou and Jacques Derrida that answers to the gamble inherent in the idea of “travelling with” the philosopher of deconstruction. Malabou's readerly text of quotations and commentary demonstrates how Derrida's work, while appearing to be anything but a travelogue, is nevertheless replete with references to geographical and topographical locations, and functions as a kind of counter-Odyssey through meaning, theorizing, and thematizing notions of arrival, drifting, derivation, and catastrophe. In fact, by going straight (...) to the heart of the Derridean idea of “spacing,” she finally makes it seem as though Derrida has never written about anything but travel. Malabou's text is punctuated by a series of postcards received by Derrida from destinations such as Istanbul and Porto, Laguna Beach and Athens, which are inspired by his reading of her evolving discussion. Writing in a familiar and unguarded manner, as if he were “on vacation” from his own writing, Derrida still remains totally faithful to that work and invites the reader to reflect on much of what haunts his texts as well as his daily life, questions of distance and death, the relation to the other, and exile. (shrink)

Uses arguments from Dharmakirti to construct an attack on Sellars' idea of an ideal scientific image.

The ability to distinguish between our own actions and those of an external agent is a fundamental component of normal human social interaction. Both low- and high-level mechanisms are thought to contribute to the sense of movement agency, but the contribution of each is yet to be fully understood. By applying small and incremental perturbations to realistic visual feedback of the limb, the influence of high-level action intentions and low-level motor predictive mechanisms were dissociated in two experiments. In the first, (...) participants were induced to claim agency over movements that were subject to large perturbations and to deny agency over self-produced unperturbed movements despite the application of motor corrections by low-level mechanisms. A control experiment confirmed that if reaches met with their intended goal then they were more likely to be attributed to the agent, regardless of the discrepancy between the actual and seen positions of the limb. (shrink)

Quelle est l'intention de Platon lorsqu'il fait de Socrate un virtuose de l'étymologie dans le Cratyle? Préciser les rapports entre la " science des lettres " qui se constitue en son siècle et la nouvelle théorie des Idées qu'il élabore. Socrate s'entretient avec le jeune Hermogène puis avec l'énigmatique Cratyle des rapports entre les mots et les choses. La rectitude des noms est-elle affaire de convention, ainsi que le soutient Hermogène? Ou s'agit-il d'un accord " naturel ", comme le prétend (...) Cratyle? Découvre-t-on cet accord par science ou par inspiration? Au terme du débat, après avoir mis à l'épreuve toutes les ressources de la " science des lettres ", Socrate propose une nouvelle théorie du nom, instrument faillible construit pour faire voir la réalité en la minant. Il dessine aussi un ordre des priorités : il faut d'abord connaître les êtres, puis les noms. " Savoir comment il faut apprendre ou découvrir les êtres, peut-être est-ce là trop lourde tâche pour toi et moi! C'est déjà beau de reconnaître qu'il ne faut pas partir des noms. ". (shrink)

This study draws on interviews with forty-nine members of a biomedical research community in the UK that is involved in negotiating data sharing and access. During an interview, an interviewee used the words “ethical moment” to describe a confrontation between collaborators in relation to data sharing. In this article, I use this as a lens for thinking about relations between “the conceptual and the empirical” in a way that allows both analyst and actor to challenge the status quo and consider (...) other ethical possibilities. Drawing on actor network theory, I approach “the empirical” using the concepts of controversy and ontological uncertainty as methodological tools to tackle the problem of ethics. I suggest that these concepts also provide a bridge for understanding the ontological structure of the virtual and the actual, as described in Deleuze’s Difference and Repetition. While other science and technology studies scholars have sought to draw on Deleuze, this article addresses the integration of ethics and empirical research. It arises as a critical reaction to existing treatments of this problem as found in empirical ethics, especially in the sociology of bioethics, and indirectly in ANT texts. (shrink)

The 'no-supervenience' theorem (Reason, 2019; Reason and Shah, 2021) is a proof that no fully self-aware system can entirely supervene on any objectively observable system. I here present a simple, non-technical summary of the proof and demonstrate its implications for four separate theories of consciousness: the 'property dualism' theory of David Chalmers; the 'reflexive monism' of Max Velmans; Galen Strawson's 'realistic monism'; and the 'illusionism' of Keith Frankish. It is shown that all are ruled out in their current form by (...) the no-supervenience theorem, except for Chalmers' theory, which I show requires humans to behave irrationally. (shrink)

In this introduction to a classic philosophical text, Catherine Wilson examines the arguments of Descartes' famous Meditations, the book which launched modern philosophy. Drawing on the reinterpretations of Descartes' thought of the past twenty-five years, she shows how Descartes constructs a theory of the mind, the body, nature, and God from a premise of radical uncertainty. She discusses in detail the historical context of Descartes' writings and their relationship to early modern science, and at the same time she introduces (...) concepts and problems that define the philosophical enterprise as it is understood today. Following closely the text of the Meditations and meant to be read alongside them, this survey is accessible to readers with no previous background in philosophy. It is well-suited to university-level courses on Descartes, but can also be read with profit by students in other disciplines. (shrink)

Judith Butler and Catherine Malabou’s recent exchange, ‘You Be My Body for Me: Body, Shape and Plasticity in Hegel’s Phenomenology of Spirit’, is remarkable because in their rereading of Hegel’s famous lord and bondsman parable, rather than focusing on recognition, work, or even desire, Butler and Malabou each wonder about how Hegel contributes to a new way of thinking about ‘having’ a body and how coming to ‘be’ a body necessarily involves a kind of dispossession. Butler and Malabou’s reading (...) of Hegel is congruent with a current shift on the left away from a liberal politics of recognition to a Marxist analytic of dispossession: a move, in other words, away from liberal ‘solutions’ of redistribution – of either goods or recognition – towards thinking through issues of settler colonialism, forced migration and empire. Butler and Malabou’s piece points towards the insight that Hegel’s parable must be thought in terms of the political history of possessive individualism, and so in terms of the history of juridically defined property relations; the history of regarding both the body and the land as property. The ‘two valences’ of dispossession, in other words, refers in fact to a logic of property relations, one between those who ‘have’ property and those who are juridically defined as propertyless. (shrink)

In the United States, the decision of whether to withdraw or continue to provide artificial nutrition and hydration (ANH) for patients in a permanent vegetative state (PVS) is placed largely in the hands of surrogate decision-makers, such as spouses and immediate family members. This practice would seem to be consistent with a strong national emphasis on autonomy and patient-centered healthcare. When there is ambiguity as to the patient's advanced wishes, the presumption has been that decisions should weigh in favor of (...) maintaining life, and therefore, that it is the withdrawal rather than the continuation of ANH that requires particular justification. I will argue that this default position should be reversed. Instead, I will argue that the burden of justification lies with those who would continue artificial nutrition and hydration (ANH), and in the absence of knowledge as to the patient's advanced wishes, it is better to discontinue ANH. In particular, I will argue that among patients in PVS, there is not a compelling interest in being kept alive; that in general, we commit a worse violation of autonomy by continuing ANH when the patient's wishes are unknown; and that more likely than not, the maintenance of ANH as a bridge to a theoretical future time of recovery goes against the best interests of the patient. (shrink)

The human animal feels fear: the ancient tranquil hordes, inhabitants of infinite plains where time stood still, have dissolved into a swarming, formless mass rushing into the future as if into the void: without a plan, without a leader, without roots; perhaps the only thing that guides it is the vague feeling of being a body whose limbs can not survive if separated.

Thomas More’s Utopia is made up of two books. Book One, quickly skimmed over by those who dream of the future and are bored by history, tells us about Europe in 1515 at the dawn of a revolution in every field of knowledge dominated by a political power that uses religion, fear and ignorance to satisfy an insatiable appetite for hegemony, infinitely corrupt but in public promoting moral, family values. Book Two gives us a glimpse of a future on a (...) human scale using new techniques, reason and good management of its resources to reconcile the common good with the pleasure of the individual. That book is the founding text for our modernity. It is the pagan bible adopted by the Enlightenment, which we have inscribed in the charter of our epoch’s institutions. Five hundred years later the books are being rewritten in reverse: the great human dream set in train by Book Two in 1516 is bogged down in the reality of 2005. The new promises of free-choice economism in 2005 are just a nightmare journey back in time to the postulates of Book One. (shrink)

The practice of terminating a pregnancy following the diagnosis of a fetal abnormality raises questions about notions of bodily normality and the ways these shape ethical decision-making. This is particularly the case with terminations done on the basis of ostensibly minor morphological anomalies, such as cleft lip and isolated malformations of the limbs or digits. In this paper, I examine a recent case of selective termination after a morphology ultrasound scan revealed the fetus to be missing a hand . Using (...) the work of Georges Canguilhem, I show that a person with acheiria could be considered normal. Further, I show that this case reveals a kind of “undecidability” in the significance of fetal sex/gender and disability in termination. From this, I consider the conceptual interaction of disability with sex/gender, to argue that the ethics of disability termination are not as distinct from those of sex/gender selection as is commonly supposed. (shrink)

The Irrational Augustine takes the notion of St Augustine as rigid and dogmatic Father of the Church and turns it on its head. Catherine Conybeare reads Augustine's earliest works to discover the anti-dogmatic Augustine, who values changeability and human interconnectedness and deplores social exclusion. The novelty of her book lies in taking seriously the nature of these early works as performances, through which multiple questions can be raised and multiple options explored, both in words and through their dramatic framework. (...) The theological consequences are considerable. A very human Augustine emerges, talking and playing with friends and family, including his mother - and a very sympathetic set of ideas is the result. (shrink)