Using this case, Lavazza and Reichlin (2018) explored the ethical dilemmas associated with decision making in people with Alzheimer’s disease (AD), specifically when their new preferences conflict...

This article investigates the potential of fMRI to test assumptions about different components in models of complex cognitive tasks. If the components of a model can be associated with specific brain regions, one can make predictions for the temporal course of the BOLD response in these regions. An event‐locked procedure is described for dealing with temporal variability and bringing model runs and individual data trials into alignment. Statistical methods for testing the model are described that deal with the scan‐to‐scan correlations (...) in the errors of measurement of the BOLD signal. This approach is illustrated using a “sacrificial” ACT‐R model that involves mapping 6 modules onto 6 brain regions in an experiment from Ravizza, Anderson, and Carter (in press) concerned with equation solving. The model's visual encoding predicted the BOLD response in the fusiform gyrus, its controlled retrieval predicted the BOLD response in the lateral inferior prefrontal cortex, and its subgoal setting predicted the BOLD response in the anterior cingulate cortex. On the other hand, its motor programming failed to predict anticipatory activation in the motor cortex, its representational changes failed to predicted the pattern of activity in the posterior parietal cortex, and its procedural component failed to predict an initial spike in caudate. The results illustrate the power of such data to direct the development of a theory of complex problem solving, both at the level of a specific task model as well as at the level of the cognitive architecture. (shrink)

The phenomenological effects of deep brain stimulation (DBS) on the self of the patient remains poorly understood and under described in the literature, despite growing evidence that a significant number of patients experience postoperative neuropsychiatric changes. To address this lack of phenomenological evidence, we conducted in-depth, semistructured interviews with 17 patients with Parkinson's disease who had undergone DBS. Exploring the subjective character specific to patients' experience of being implanted gives empirical and conceptual understanding of the potential phenomenon of DBS-induced self-estrangement. (...) Our study concluded that (1) the more patients preoperatively felt alienated by their illness, the more they experienced postoperative self-estrangement, and (2) the notion of self-estrangement seems to exist in association with certain common qualitative characters, namely, loss of control, which reflects a deteriorative estrangement, and distorted perception of capacities, which reveals a restorative estrangement. These findings indicate that subjective self-reports help us to understand some aspects of the potential phenomenon of DBS-induced self-estrangement. (shrink)

Should there be a female age limit on public funding for assisted reproductive technology (ART)? The question bears significant economic and sociopolitical implications and has been contentious in many countries. We conceptualise the question as one of justice in resource allocation, using three much-debated substantive principles of justice—the capacity to benefit, personal responsibility, and need—to structure and then explore a complex of arguments. Capacity-to-benefit arguments are not decisive: There are no clear cost-effectiveness grounds to restrict funding to those older women (...) who still bear some capacity to benefit from ART. Personal responsibility arguments are challenged by structural determinants of delayed motherhood. Nor are need arguments decisive: They can speak either for or against a female age limit, depending on the conception of need used. We demonstrate how these principles can differ not only in content but also in the relative importance they are accorded by governments. Wide variation in ART public funding policy might be better understood in this light. We conclude with some inter-country comparison. New Zealand and Swedish policies are uncommonly transparent and thus demonstrate particularly well how the arguments we explore have been put into practice. (shrink)

Bioethical decision‐making in pediatrics diverges from similar decisions in other medical domains because the young child is not an autonomous decision‐maker, while the teen is developing—and should be encouraged to develop—autonomy and decisional capacity. Thus the balance between autonomy and beneficence is fundamentally different in pediatrics than in adult medicine. While ethical dilemmas that reflect these fundamental issues are common, many pediatric physician and nursing training programs do not delve into the issues or offer specific training about how to deal (...) with borderline cases.To meet this need, the Children's Mercy Bioethics Center in Kansas City, Missouri, created a program specifically dedicated to serving practicing, experienced pediatric health professionals. Our students come from various professional disciplines: they are doctors, nurses, social workers, chaplains, lawyers, psychologists, counselors, and hospital administrators practicing in pediatrics. (shrink)

NEITHER in the scholarly nor in the philosophical literature on Aristotle does his account of friendship occupy a very prominent place. I suppose this is partly, though certainly not wholly, to be explained by the fact that the modern ethical theories with which Aristotle’s might demand comparison hardly make room for the discussion of any parallel phenomenon. Whatever else friendship is, it is, at least typically, a personal relationship freely, even spontaneously, entered into, and ethics, as modern theorists tend to (...) conceive it, deals rather with the ways in which people are required to regard, and behave toward, one another, than with the organization of their private affairs. To the extent, then, that one shares this modern outlook one will tend to neglect, or treat merely as an historical curiosity, Aristotle’s efforts to define friendship and to place it within the framework of human eudaimonia, the theory of which is central to moral philosophy as he understands it. Yet in the Nicomachean Ethics the two books on φιλία make up nearly a fifth of the whole, and this seems to me a fair measure of the importance of this subject to the complete understanding both of Aristotle’s overall moral theory and even of many of the more circumscribed topics to which so much scholarly and philosophical attention has been devoted. If, as I suggest, the failure of commentators to appreciate its importance is partly the effect of distortions produced by the moral outlook that has predominated in modern moral philosophy, the careful study of these books may help to free us from constricting prejudices and perhaps even make it possible to discover in Aristotle a plausible and suggestive alternative to the theories constructed on the narrower base characteristic of recent times. (shrink)

This book brings together twenty-three distinctive and influential essays on ancient moral philosophy--including several published here for the first time--by the distinguished philosopher and classical scholar John Cooper.

I discuss the division of the soul in plato's "republic". i concentrate on the arguments and illustrative examples given in book iv, but i treat the descriptions of different types of person in viii-ix and elsewhere as further constituents of a single, coherent theory. on my interpretation plato distinguishes three basic kinds of motivation which he claims all human beings regularly experience in some degree. reason is itself the immediate source of certain desires. in addition, there are appetitive and also--quite (...) distinct from either of the other two--competitive motivations. (shrink)

Knowledge, Nature, and the Good brings together some of John Cooper's most important works on ancient philosophy. In thirteen chapters that represent an ideal companion to the author's influential Reason and Emotion, Cooper addresses a wide range of topics and periods--from Hippocratic medical theory and Plato's epistemology and moral philosophy, to Aristotle's physics and metaphysics, academic scepticism, and the cosmology, moral psychology, and ethical theory of the ancient Stoics.Almost half of the pieces appear here for the first time or (...) are presented in newly expanded, extensively revised versions. Many stand at the cutting edge of research into ancient ethics and moral psychology. Other chapters, dating from as far back as 1970, are classics of philosophical scholarship on antiquity that continue to play a prominent role in current teaching and scholarship in the field. All of the chapters are distinctive for the way that, whatever the particular topic being pursued, they attempt to understand the ancient philosophers' views in philosophical terms drawn from the ancient philosophical tradition itself.Through engaging creatively and philosophically with the ancient texts, these essays aim to make ancient philosophical perspectives freshly available to contemporary philosophers and philosophy students, in all their fascinating inventiveness, originality, and deep philosophical merit. This book will be treasured by philosophers, classicists, students of philosophy and classics, those in other disciplines with an interest in ancient philosophy, and anyone who seeks to understand philosophy in philosophical terms. (shrink)

Stephen Law developed a challenge to theism, known as the evil-god challenge (Law (2010) ). The evil-god challenge to theism is to explain why the theist’s responses to the problem of evil are any better than the diabolist’s – who believes in a supremely evil god – rejoinders to the problem of good, when all the theist’s ploys (theodicy, sceptical theism, etc.) can be parodied by the diabolist. In the first part of this article, I extend the evil-god challenge by (...) showing that additional theist replies to the problem of evil (more theodicies, the privation view of evil, and others) also may be appropriated, with just as much plausibility, in support of the diabolist position. In the second part of the article, I defend the evil-god challenge against several objections. (shrink)

Michael Bergmann has argued that internalist accounts of justification face an insoluble dilemma. This paper begins with an explanation of Bergmann’s dilemma. Next, I review some recent attempts to answer the dilemma, which I argue are insufficient to overcome it. The solution I propose presents an internalist account of justification through direct acquaintance. My thesis is that direct acquaintance can provide subjective epistemic assurance without falling prey to the quagmire of difficulties that Bergmann alleges all internalist accounts of justification cannot (...) surmount. (shrink)

The ancient Stoics notoriously argued, with thoroughness and force, that all ordinary “emotions” (passions, mental affections: in Greek, pãyh) are thoroughly bad states of mind, not to be indulged in by anyone, under any circumstances: anger, resentment, gloating; pity, sympathy, grief; delight, glee, pleasure; impassioned love (i.e. ¶rvw), agitated desires of any kind, fear; disappointment, regret, all sorts of sorrow; hatred, contempt, schadenfreude. Early on in the history of Stoicism, however, apparently in order to avoid the objection that human nature (...) itself demands and indeed justifies—under certain circumstances at any rate—emotional attachments to or aversions from, and reactions to, some persons, things, and happenings, they introduced a theory of what came to be called eÈpãyeiai, good and acceptable ways of feeling or being affected. For short I will render these in English by “good feelings.”1 They divided these into three generic kinds, which they dubbed “joy” (xarã), “wish” (boÊlhsiw) and “caution” (eÈlãbeia). They ranged these alongside, and set them in sharp contrast to, three of the four highest genera into which they divided the normal human emotions: “pleasure” (≤donÆ), i.e., being pleased about something,2 “appetitive desire” (§piyuµ€a), and “fear” (fÒbow), respectively. The Stoics maintained that, though ordinary, familiar human emotions such as these last-named ones were always bad, the three sorts of “good feeling,” and their more specific variations (since these three are only the basic genera into which lots of other good ways of feeling will fall), were not merely free from the grounds of criticism on which ordinary emotions were rejected, and so were perfectly acceptable. The fully perfected human being (the “wise person”) would indeed regularly be subject to them.3 Their theory of the perfect human life did not, then, they could claim, require any outrageously unnatural demand, presumably unrealizable in any case, for a life completely without all feelings of involvement in the sweep and flow of life.. (shrink)

John Rist surveys the history of ethics from Plato to the present and offers a vigorous defence of an ethical theory based on a revised version of Platonic realism. In a wide-ranging discussion he examines well-known alternatives to Platonism, in particular Epicurus, Hobbes, Hume and Kant as well as contemporary 'practical reasoners', and argues that most post-Enlightenment theories of morality (as well as Nietzschean subversions of such theories) depend on an abandoned Christian metaphysic and are unintelligible without such grounding. (...) He also argues that contemporary choice-based theories, whether they take a strictly ethical or more obviously political form, are ultimately arbitrary in nature. His lively and accessible 2001 study is informed by a powerful sense of philosophical history, and will be of interest to both students and scholars of ethics. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Papirius and the Chickens, or Machiavelli on the Necessity of Interpreting ReligionJohn M. Najemy*No aspect of Machiavelli’s thought elicits a wider range of interpretations than religion, and one may wonder why his utterances on this subject appear to move in so many different directions and cause his readers to see such different things. One reason is of course his famous challenge to conventional piety in the advice to princes (...) (in chapter 18 of The Prince) that, while it is important to appear to be “all compassion, faith, integrity, humanity, and religione, and there is nothing more necessary for a prince than to appear to have the last of these,” these “qualities” can actually be “damaging” if a prince insists on observing them at all times. For it is sometimes necessary to act “against faith, against charity, against humanity, and against religione.” 1 Machiavelli probably never wrote more famous or infamous words than these, even though they express an obvious, and hardly original, truth about all politics. But the world of the later sixteenth- and seventeenth-century reformations and religious absolutisms could not tolerate such honesty, and Machiavelli’s reputation was quickly tarred with accusations of devilish immorality by the very societies that thought it was godly to burn heretics. On the issue of religion Machiavelli became, and to some extent remains, a convenient scapegoat often blamed for the decline of religion in the modern world, all of which has no doubt intensified the polemical and ideological nature of the debates surrounding his views of religion in general and Christianity in particular. [End Page 659]The polar positions in the interpretation of Machiavelli’s ideas about religion are represented by Leo Strauss and Sebastian de Grazia. For Strauss, Machiavelli was a “teacher of evil,” a “blasphemer,” and a purveyor of lessons of a “diabolical” and “soulless character” whose purpose was to sabotage the heritage of thought and morality inherited from both Christianity and Greek philosophy. 2 De Grazia, by contrast, has recently given us a Machiavelli who “discourses about God always in the conventional reverent attitude,” who “never questions that there is good and evil,” and who, “by associating virtuous political action with grace and glory... argues that through this kind of active and political virtue men conform to God’s desire.” “Behind Niccolò’s insistence on political action,” says de Grazia, “stands God. He grants His grace when it is earned—in political coin.” 3 Part of the fascination of Machiavelli scholarship is the mystery of how this most outspoken and direct of political thinkers—a writer who pulled no punches and minced no words—could be the common referent of such wildly different readings. But it is equally curious to observe how uncannily these extreme positions mirror each other. Both give us true believers, one in the Word, the other in the subversion of the Word; and in both cases a believer who is always of a piece, true to himself, and possessed of an unshakeable commitment—whether positive or negative—toward the transcendent truth of Christianity. In short, for all the obvious differences, the similarities between Strauss’s “diabolical” Machiavelli and de Grazia’s reverent “friend of God” remind one of the old myth that devils are after all only fallen angels.The papers in this forum should certainly remove any doubt about the importance of religion in Machiavelli’s thought. They remind us of the prominence of religious language and examples in Machiavelli’s texts: his call for the “redemption” of Italy in the last chapter of The Prince; the esteem in which he holds the heads and founders of religions, whom he declares, in Discourses 1.10, to be the most praised of all famous men; the crucial appeal to the figure of Moses as the prototype of both founders of states and liberators of enslaved peoples; the central role that Machiavelli attributes to religion among the factors responsible for Rome’s power, unity, and political success; and his provocative critique of Christianity, which leads him, in a number of places, to blame the Christian faith for the relative weakness of both modern states and the modern ethic of citizenship. 4 The authors... (shrink)

Background: A growing literature has raised—skeptically—the question of whether cutting-edge scientific research can identify and address broader ethical and policy considerations in real time. In genomics, the question is: Can ELSI contribute to genomics in real time, or will it be relegated to its historical role of after-the-fact outsider critique? We address this question against the background of a genomic screening project where we participated as embedded, real-time ELSI researchers and observers, from its initial design through its conclusion.Methods: As part (...) of the ELSI study design, the project included an ongoing reflexive ethnography in which the authors studied the process of its design and implementation. The authors were true participant observers, serving as members of various task-oriented groups while recording meetings and other events for ongoing qualitative analysis. We also conducted and analyzed interviews of multiple participants at the conclusion of the project.Results: Our real-time ELSI initiative had a mixed record of successes and challenges. If we define success as ELSI researchers having had an opportunity to participate fully in the project and to make the ELSI perspective heard, then our assessment is largely positive. If, however, we define successes as instances where real-time ELSI contributions changed the direction of the genomic or public health aspects of the GeneScreen project or, after careful deliberation, confirmed the appropriateness of the status quo, then we can identify only a few examples. While we had a seat at the table, we were, for the most part, tolerated guests.Conclusions: We conclude that there are significant barriers to real-time ELSI influence. The difficulty does not reside in any intended exclusion of an ELSI perspective, but in factors endemic to genomic research, including knowledge disparities, epistemological biases, and the pressures of time and money. (shrink)

Jerry Fodor argues that the massive modularity thesis – the claim that (human) cognition is wholly served by domain specific, autonomous computational devices, i.e., modules – is a priori incoherent, self-defeating. The thesis suffers from what Fodor dubs the input problem: the function of a given module (proprietarily understood) in a wholly modular system presupposes non-modular processes. It will be argued that massive modularity suffers from no such a priori problem. Fodor, however, also offers what he describes as a really (...) real input problem (i.e., an empirical one). It will be suggested that this problem is real enough, but it does not selectively strike down massive modularity – it is a problem for everyone. (shrink)

These and other examples of faculty misconduct -- and how to avoid them -- are the subject of this book.

Feldman and Turner defend the making of so-called ‘NIMBY’ claims as ethically justifiable. They do so while confronting a case—Robert F. Kennedy Jr.'s opposition to the Cape Wind Project in Nantuck...

While society debates whether and how to use public funds to support work on human embryonic stem cells (hESCs), many scientific groups and businesses debate a different question — the extent to which patents that cover such stem cells should be permitted to limit or to tax their research. The Wisconsin Alumni Research Foundation (WARF), a non-profit foundation that manages intellectual property generated by researchers at the University of Wisconsin at Madison, owns three patents that have been at the heart (...) of the latter controversy The story of WARF's patents and the controversy they have fostered highlights not only continuing tensions between proprietary and nonproprietary approaches to developing science and technology, but also an at least partly reassuring capacity of public and private sectors to deal with those tensions in a way that can render them substantially manageable, and frequently more manageable as a technology matures. More particularly, the cumulative story of WARF's patents features three leitmotifs that suggest how an attentive and engaged public sector might commonly succeed in working with public and private sector actors to achieve workable balances between proprietary rights and more general social interests: (1) right holders' decisions to pursue less than full rights assertion or enforcement; (2) the ability of government and other public sector actors to help bring about such decisions through co-option or pressure; and (3) the frequent availability or development of technological alternatives that limit research bottlenecks. (shrink)

In Faculty Misconduct in Collegiate Teaching, higher education researchers John Braxton and Alan Bayer address issues of impropriety and misconduct in the teaching role at the postsecondary level. Braxton and Bayer define and examine norms of teaching behavior: what they are, how they come to exist, and how transgressions are detected and addressed. Do faculty members across various collegiate settings, for example, share views about appropriate and inappropriate teaching behaviors, as they share expectations regarding actions related to research? And (...) what mechanisms are utilized to correct inappropriate behavior on the part of college and university teachers? The authors' work is based on survey results obtained from faculty members at research universities, liberal arts colleges, and two-year community, junior, and technical colleges. Braxton and Bayer's focus is on undergraduate teaching in four disciplines: biology, history, mathematics, and psychology. In their analyses, the authors examine how individual, disciplinary, and institutional differences influence professorial behavior. In contrast to the more explicitly understood and enforced rules of conduct in research, the authors find that teaching norms are informally defined and observed. They argue that a formal code of ethics for undergraduate teaching would serve the dual purpose of improving undergraduate education and elevating the status of college teaching. A groundbreaking study of contemporary academe, Faculty Misconduct in Collegiate Teaching is required reading for all university and college instructors and administrators. (shrink)

The neurological experiments conducted by Benjamin Libet (1985) and Grey Walter (1993, in Dennett) provide evidence that our actions are caused by non-conscious brain events beyond our conscious awareness. Normally, we assume that our conscious choices lead us to do things. If these researchers have interpreted their evidence correctly, it may be that we lack free-will, for we could not control a non-conscious brain state. Libet however provides evidence that agents can “change their minds” just before performing some action. He (...) felt that this was the elbow-room for free-will. But it may be inconsistent for him to suggest this, since his evidence indicates that there is no room for conscious choice. In this paper we discuss these results and various objections to the interpretation of the work. South African Journal of Philosophy Vol. 26 (3) 2007: pp. 271-288. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:275 DAVID HUME AND THE CONCEPT OF VOLITION Introduction The following two papers, though separately authored, belong together, not only because we, the authors, shared our views during the writing, but also because they are excerpts from a single story we are interested in telling. This is the story of a particular insight into the conceptual structure of human volition — the will. The insight is that volition — (...) or, more precisely, intention — is (or presupposes) a kind of knowledge, practical knowledge. Our larger goal is to show how this insight was developed from the time of Aristotle into the Middle Ages, and then fell into obscurity in modern philosophy until quite recently. This insight became especially clear in the writings of Thomas Aquinas. The epistemological development which obscured it was most powerfully furthered by David Hume. The recovery of the insight was initially the work of the later Wittgenstein. The first paper deals with Aquinas; the second with Wittgenstein; and both with Hume.... (shrink)

Recent analysis of the contribution of replication slippage to genome evolution shows that it has played a significant role in all species from eubacteria to humans. The overall level of repetition in genomes is related to genome size and to the degree of repetition that can be measured within individual ribosomai RNA genes, suggesting that the entire genome accepts simple sequences in a concerted manner when its size increases. Although coding sequences accept simple sequences much less readily than non‐coding sequences, (...) they accept some repeats, particularly (CAG)n, preferentially. This may have consequences for the evolution of the genes involved in trinucleotide expansion diseases and the transcriptional networks of which they may form a part. (shrink)