By the end of the 1820s, an innovative product was introduced in the northern Italian editorial market: technical and popular periodicals offering “useful knowledge” to a larger audience composed of members of the provincial middle-class, clergymen, and modestly educated craftsmen. By examining their medical content, this paper shows that popularisation did not merely entail disseminating a set of stable, unanimous, and trustworthy medical doctrines; rather, it represented a crucial step in the making of science during a period in which medical (...) theories were still various and contradictory. Moreover, it demonstrates that the environmental and preventative approach to disease, which these medical contributors often employed, did reflect recent developments in chemical or physical knowledge and responded to pedagogical and informative goals; but it mostly served to affirm the social usefulness of medicine and the legitimacy of health professionals' participation in determining how to regulate more general epidemiologic, social, and political issues. (shrink)

The history of women has been defined by a world enmeshed in woes, frustration, oppression, maltreatment and inequalities. Feminism as a philosophy of change sought to fight, end and change this woeful scenario of women that denied their self respect, dignity and led to a loss of self confidence. Fundamentally, feminist philosophy sought for explanations and justifications why women were denied a voice and why they were historically not treated as coequals of men. The basis of inequality is historically rooted (...) in cultural and philosophical falsities that were not evidenced based but were used to justify oppression against women. The Universal Declaration of human rights gave women and the world the platform that empowered them with rights and led to fresh processes that sought to end oppression and their underdevelopment inspired by inequality, iniquities, denial of opportunities for growth and empowerment. The millennium development goal of ending inequality and oppression against women should achieve equality and women’s empowerment in Africa. Since the declaration of the MDGS, considerable gains had been made inAfricabut challenges and problems are still identified in the areas of cultural inequality complicated by the weakness of the major governance institutions and corruption. Other challenges centre on women’s lack of genuine empowerment, violence against women, trafficking in women, denial of human rights, lack of participation in policy and governance. Since empowerment is the key to achieving mainstreaming and gender equality, this paper seeks to redefine the concept of empowering women as the platform to ending inequality, social injustice and achieving equality in the context of the unique challenges of underdevelopment facingAfrica. It will identify the policy implications of establishing empowerment structures that address multiple challenges facing gender inequality and how these structures will assist in building the necessary feminine human resources that will make women as partners of sustainable growth and development after 2015. (shrink)

One can say that there is inadequate preparation, in Africa, to embrace the fourth industrial revolution. Two schools of thought argue as to the reason for this state of affair. While the Internalist school blames the situation on Africa’s culture and metaphysics, the Externalist school considers external factors as the ultimate explanation for Africa’s plight. We argue that both internal and external factors considered separately are not sufficient as the ultimate explanation for Africa’s lack of preparation, hence the need for (...) a multi-dimensional approach which offers more than the conventional wisdom but critically considers what constitutes a complex explanation and solution for Africa’s plight. Furthermore, we suggest that more attention should be paid to Africa’s existential situation if she must rise to take her place in the emerging revolution. The study initiates a conversation around the theme of Africa’s fate in the looming fourth industrial revolution using phenomenological methods of research. (shrink)

In this review, we discuss the application of mouse models to the identification and pre‐clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large‐scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross‐species comparative ‘omics‐based approaches to this problem. We highlight recent progress in modelling late‐stage disease using (...) mice, and discuss ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection. (shrink)

Whether due to simplicity or hypocrisy, the question of access to patient data for biomedical research is widely seen in the public discourse only from the angle of patient privacy. At the same time, the desire to live and to live without disability is of much higher value to the patients. This goal can only be achieved by extracting research insight from patient data in addition to working on model organisms, something that is well understood by many patients. Yet, most (...) biomedical researchers working outside of clinics and hospitals are denied access to patient records when, at the same time, clinicians who guard the patient data are not optimally prepared for the data’s analysis. Medical data collection is a time- and cost-intensive process that is most of all tedious, with few elements of intellectual and emotional satisfaction on its own. In this process, clinicians and bioinformaticians, each group with their own interests, have to join forces with the goal to generate medical data sets both from clinical trials and from routinely collected electronic health records that are, as much as possible, free from errors and obvious inconsistencies. The data cleansing effort as we have learned during curation of Singaporean clinical trial data is not a trivial task. The introduction of omics and sophisticated imaging modalities into clinical practice that are only partially interpreted in terms of diagnosis and therapy with today’s level of knowledge warrant the creation of clinical databases with full patient history. This opens up opportunities for re-analyses and cross-trial studies at future time points with more sophisticated analyses of the same data, the collection of which is very expensive. (shrink)

While much attention has gone towards ethical, legal, and social implications of direct-to-consumer genetic testing over the past decades, the rise of new forms of consumer omics has largely escaped scrutiny. In this paper, we analyze the product descriptions, promotional messages, terms of service, and privacy policies of five epigenetic and seven microbiomic testing companies. The advent of such tests online represents a significant shift in consumer omics, from a focus on inherited molecules with genetic tests, to broader (...) interest for information about the lives of individuals, such as chronological and biological age, exposures, and lifestyle. Building on previous literature about direct-to-consumer genetic testing, and taking this shift into account, we identify limitations, gaps and inconsistencies in current practices and policies of the new companies. Best practice standards and regulations applicable across different omic sample and data types is a necessary first step in the promotion of responsible consumer omics. (shrink)

Dupras and Bunnik’s strong statement against the normative approach of genetic exceptionalism, which can no longer be justified in the midst of multi-omic research, is of great importance fo...

Funding organizations around the world are adopting open science policies, resulting in a pressing need for open science programs. In response to the 2011 decadal survey, NASA sought to expand and accelerate omics research, releasing its GeneLab Strategic Plan in 2014. GeneLab is an open science data repository and analysis portal for spaceflight and space-relevant omics data. GeneLab’s output has been outstanding, but its full potential as a way to transform space biology has not yet been achieved. NASA (...) should pursue the development of GeneLab as an open science platorm in earnest. (shrink)

The conference explored an extraordinary diversity of aging strategies in organisms ranging from short‐lived species to “immortal” animals and plants. Research on the biological processes of aging is at the brink of a revolution with respect to our understanding of its underlying mechanisms as well as our ability to prevent and cure a wide variety of age‐related pathologies.

While the accumulation and increased circulation of genomic data have captured much attention over the past decade, privacy risks raised by the diversification and integration of omics have been la...

The Diagnostic and Statistical Manual of Mental Disorders (DSM) is universally acknowledged as the prominent reference textbook for the diagnosis and assessment of psychiatric diseases. However, since the publication of its first version in 1952, controversies have been raised concerning its reliability and validity and the need for other novel clinical tools has emerged. Currently the DSM is in its fourth edition and a new fifth edition is expected for release in 2013, in an intense intellectual debate and in a (...) call for new proposals. (shrink)

[Without a theorising], a man might as well go into a gravel-pit and count the pebbles and describe the colours. How odd it is that anyone should not see that all observation must be for or against some view if it is to be of any service!Recent years have seen a steady shift of funding programs in biomedical research towards data collection, analysis, and management and its computational analysis. A sizable majority of new major funding opportunity announcements call for assembling (...) large sample banks and databases of molecular profiles of diseases or for computational tools for analysis, display, and distribution of the data. Large consortium projects, such as the Cancer Genome Atlas, the UK Biobank (Allen... (shrink)

In ‘Toward a Framework for Assessing Privacy Risks in Multi-Omic Research and Databases’ (Dupras and Bunnik 2021), we argued against the assessment of privacy risks and protection requirements base...

As part of a (bio)colonial project, the biological information of Indigenous Peoples has historically been under scientific scrutiny, with very limited benefits for communities and donors. Negative past experiences have contributed to further exclude Indigenous communities from novel developments in the field of omics research. Over the past decade, new guidelines, reflections, and projects of genetic research with Indigenous Peoples have flourished in Australia, providing opportunities to move the field into a place of respect and ethical relationships. This review (...) explores the ethical and cultural implications of the use of biological samples from Indigenous communities in biomedical research. A structured framework outlining emerging topics of interest for the development of respectful omics research partnerships with Indigenous Australians is presented. This paper highlights aspects related to Indigenous governance, community and individual consent, respectful handling of biological samples, data management, and communication in order to protect Indigenous interests and rights and to promote communities’ autonomy. (shrink)

This paper argues that analyses of the ways in which Big Data has been enacted in other academic disciplines can provide us with concepts that will help understand the application of Big Data to social questions. We use examples drawn from our Science and Technology Studies analyses of -omic biology and high energy physics to demonstrate the utility of three theoretical concepts: primary and secondary inscriptions, crafted and found data, and the locus of legitimate interpretation. These help us to show (...) how the histories, organisational forms, and power dynamics of a field lead to different enactments of big data. The paper suggests that these concepts can be used to help us to understand the ways in which Big Data is being enacted in the domain of the social sciences, and to outline in general terms the ways in which this enactment might be different to that which we have observed in the ‘hard’ sciences. We contend that the locus of legitimate interpretation of Big Data biology and physics is tightly delineated, found within the disciplinary institutions and cultures of these disciplines. We suggest that when using Big Data to make knowledge claims about ‘the social’ the locus of legitimate interpretation is more diffuse, with knowledge claims that are treated as being credible made from other disciplines, or even by those outside academia entirely. (shrink)

The framework proposed by Dupras and Bunnik was developed in response to their recognition that standard regulations are increasingly inadequate to address the complex privacy issues created by the...

Several metabolites serve as substrates for histone modifications and communicate changes in the metabolic environment to the epigenome. Technologies such as metabolomics and proteomics have allowed us to reconstruct the interactions between metabolic pathways and histones. These technologies have shed light on how nutrient availability can have a dramatic effect on various histone modifications. This metabolism–epigenome cross talk plays a fundamental role in development, immune function, and diseases like cancer. Yet, major challenges remain in understanding the interactions between cellular metabolism (...) and the epigenome. How the levels and fluxes of various metabolites impact epigenetic marks is still unclear. Discussed herein are recent applications and the potential of systems biology methods such as flux tracing and metabolic modeling to address these challenges and to uncover new metabolic–epigenetic interactions. These systems approaches can ultimately help elucidate how nutrients shape the epigenome of microbes and mammalian cells. (shrink)

The first 1000 days of life, from conception to 2 years, are a critical window for the influence of environmental exposures on the assembly of the oral microbiome, which is the precursor to dental caries (decay), one of the most prevalent microbially induced disorders worldwide. While it is known that the human microbiome is susceptible to environmental exposures, there is limited understanding of the impact of prenatal and early childhood exposures on the oral microbiome trajectory and oral health. A barrier (...) has been the lack of technology to directly measure the foetal "exposome", which includes nutritional and toxic exposures crossing the placenta. Another barrier has been the lack of statistical methods to account for the high dimensional data generated by‐omic assays. Through identifying which early life exposures influence the oral microbiome and modify oral health, these findings can be translated into interventions to reduce dental decay prevalence. (shrink)

In the last decades, Systems Biology (including cancer research) has been driven by technology, statistical modelling and bioinformatics. In this paper we try to bring biological and philosophical thinking back. We thus aim at making diferent traditions of thought compatible: (a) causality in epidemiology and in philosophical theorizing—notably, the “sufcient-component-cause framework” and the “mark transmission” approach; (b) new acquisitions about disease pathogenesis, e.g. the “branched model” in cancer, and the role of biomarkers in this process; (c) the burgeoning of (...) class='Hi'>omics research, with a large number of “signals” and of associations that need to be interpreted. In the paper we summarize frst the current views on carcinogenesis, and then explore the relevance of current philosophical interpretations of “cancer causes”. We try to ofer a unifying framework to incorporate biomarkers and omic data into causal models, referring to a position called “evidential pluralism”. According to this view, causal reasoning is based on both “evidence of diference-making” (e.g. associations) and on “evidence of underlying biological mechanisms”. We conceptualize the way scientists detect and trace signals in terms of information transmission, which is a generalization of the mark transmission theory developed by philosopher Wesley Salmon. Our approach is capable of helping us conceptualize how heterogeneous factors such as micro and macro-biological and psycho-social—are causally linked. This is important not only to understand cancer etiology, but also to design public health policies that target the right causal factors at the macro-level. (shrink)

In their article “Implementing Expanded Prenatal Genetic Testing: Should Parents Have Access to Any and All Fetal Genetic Information?” Bayefsky and Berkman briefly mention that: “[s]ome are...

Este artículo es el resultado de una investigación del programa de Maestría en Educación de la universidad la Gran Colombia; se propuso como objetivo general determinar cómo construyen la categoría “valor” estudiantes de grado once de dos colegios de la ciudad de Bogotá, con edades que oscilan entre quince y diecinueve años respectivamente. El enfoque metodológico fue de carácter cualitativo en el cual se utilizaron las técnicas de recolección de información: grupos focales y entrevistas a profundidad, que tuvieron el propósito (...) de recoger e interpretar la asignación de sentidos y representaciones expresadas en las narrativas de los actores participantes. Algunos de los hallazgos sugieren que las percepciones de la población objeto de estudio sobre la categoría “valor” están relacionadas con procesos de subjetivación que se construyen en la vida cotidiana en dinámicas complejas y no necesariamente lineales, como resultados de acuerdos sociales. De otra parte, existe una tendencia significativa a construir la categoría “valor” de acuerdo con las necesidades, intereses y motivaciones que se generan en el contexto escolar, lo que produce conflictos, contradicciones y valoraciones morales que muchas veces devienen en lucha de fuerza con las instituciones. Se destaca entre otras conclusiones, el juego en que se sumergen los estudiantes a partir de prácticas éticas asociadas a la categoría “valor” de carácter teleológico, porque las conductas intentan evitar un castigo o alcanzar un premio; y autotélicas porque los comportamientos producen felicidad en el hacer. (shrink)

Dupras and Bunnik take on the particular privacy risks of multi-omics, in particular via a contrast and comparison of genomics and epigenomics, followed by a consideration of the issues in r...

Pre-natal exposure to acute maternal trauma or chronic maternal distress can confer increased risk for psychiatric disorders in later life. Acute maternal trauma is the result of unforeseen environmental or personal catastrophes, while chronic maternal distress is associated with anxiety or depression. Animal studies investigating the effects of pre-natal stress have largely used brief stress exposures during pregnancy to identify critical periods of fetal vulnerability, a paradigm which holds face validity to acute maternal trauma in humans. While understanding these effects (...) is undoubtably important, the literature suggests maternal stress in humans is typically chronic and persistent from pre-conception through gestation. In this review, we provide evidence to this effect and suggest a realignment of current animal models to recapitulate this chronicity. We also consider candidate mediators, moderators and mechanisms of maternal distress, and suggest a wider breadth of research is needed, along with the incorporation of advanced -omics technologies, in order to understand the neurodevelopmental etiology of psychiatric risk. (shrink)

Biobanks and biospecimen collections are becoming a primary means of delivering personalized diagnostics and tailoring individualized therapeutics. This shift towards precision medicine requires interactions among a variety of stakeholders, including the public, patients, healthcare providers, government, and donors. Very few studies have investigated the role of healthcare students in biobanking and biospecimen donations. The main aims of this study were to evaluate the knowledge of senior healthcare students about biobanks and to assess the students’ willingness to donate biospecimens and the (...) factors influencing their attitudes. A cross-sectional study was conducted among senior healthcare students at King Abdulaziz University, Saudi Arabia. The data were obtained using a self-administered questionnaire in English. In addition to the respondents’ biographical data section, the questionnaire assessed the respondents’ general knowledge about biobanking, the factors influencing their willingness to donate biospecimens to biobanks and their general attitudes towards biomedical research. A total of 597 senior healthcare students were included in the study. The general knowledge score was 3.2 out of 7. Only approximately 44% and 27% of students were aware of the terms “Human Genome Project” and “biobank,” respectively. The majority of the students were willing to donate biospecimens to biobanks. Multiple factors were significantly associated with their willingness to donate, including their perceived general health, past experience with both tissue testing and tissue donation, biobanking knowledge score and biomedical research attitude score. The main reasons for students’ willingness to donate were advancement of medical research and societal benefits, whereas misuse of biospecimens and confidentiality breaches were the main reasons for a reluctance to donate. Despite their strong willingness to donate biospecimens, students exhibited a notable lack of knowledge about biobanking and the HGP. To expedite the transition towards PM, it is highly recommended to enhance healthcare curricula by including more educational and awareness programmes to familiarize students with OMICs technologies in addition to the scope of research and clinical applications. (shrink)

Co-learning of multiple agents has been studied in co-learning settings, and how do they help, or many different disciplines under various guises. For hamper, learning and cooperation? example, the issue has been tackled by distributed • How do we characterize the process and the artificial intelligence, parallel and distributed com- dynamics of co-learning, conceptually, mathe- puting, cognitive psychology, social psychology, matically, or computationally? game theory (and other areas of mathematical econ- • how do social structures and relations interact omics), (...) sociology, anthropology, and many other with co-learning of multiple agents? related disciplines. (shrink)

Social scientists have shown that scientific characterizations of the egg and the sperm are shaped by gender stereotypes and cultural values. How have such characterizations been transformed by a recent embrace of -omics, when studies of reproduction increasingly go beyond genomics to incorporate proteomics, transcriptomics, exposomics, and other -omics perspectives? Scientists studying reproduction and analyzing eggs, sperm, and embryos are in some ways reimagining the roles, identities, and functions of gametes as fundamentally shaped by other molecular entities and (...) environments. Such relational understandings of substances and processes, however, continue to operate through a teleology that often conscripts more nuanced -omics reflection into familiar genomic visions of sex and reproduction. While ideas of the gene as an alienable object may be unraveling, -omics efforts to go beyond the egg and the sperm are frequently constricted by an understanding of reproduction that remains tied to individualized bodies and by a genomically infused interpretation of the gamete as life itself. (shrink)

This article explores the overlap between systems biology and predictive neuroscience, placing them in their larger context, the contemporary trend of bioinformatic convergence across the sciences. These two domains overlap with respect to their interest in data accumulation and data integration; their reliance on computational statistical correlation; and their translational goals, that is, producing practical fruits and applications from the interscientific cross-pollination that contemporary data-integrative approaches make possible. The interventions that such translational conversations generate are medical and social in nature, (...) and are aimed at both prevention and treatment. It will be argued that such approaches, socially and medically applied, contain potential for conveying both agency-enhancing and agency-diminishing social messages. The article concludes with a call to balance the overwhelmingly quantitative focus characteristic of predictive neuroscience with more qualitative empirical methodologies. This would represent a double helical approach. (shrink)

It is estimated that 300,000 children 0–14 years of age are diagnosed with cancer worldwide each year. While the absolute risk of cancer in children is low, it is the leading cause of death due to disease in children in high‐income countries. In spite of this, the etiologies of pediatric cancer are largely unknown. Environmental exposures have long been thought to play an etiologic role. However, to date, there are few well‐established environmental risk factors for pediatric malignancies, likely due to (...) technical barriers in collecting biological samples prospectively in pediatric populations for direct measurements. In this review, we propose the use of novel or underutilized biospecimens (dried blood spots and teeth) and molecular approaches for exposure assessment (epigenetics, metabolomics, and somatic mutational profiles). Future epidemiologic studies of pediatric cancer should incorporate novel exposure assessment methodologies, data on molecular features of tumors, and a more complete assessment of gene‐environment interactions. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Martin Steinmann INTRINSIC MERIT AND MULTICULTURALISM O OME proponents of multiculturalism argue as follows: There is no such thing as intrinsic merit. Therefore, the hegemony ofwestern culture in America is not due to its intrinsic merit. Therefore, it is due only to the political and economic power of white Americans of European ancestry, especially males. Therefore, it might yield to a new order in which all cultures represented in (...) America, whatever dieir origin, have equal authority, influence, and status in schools, colleges, and universities, in theaters and concert halls, in museums and galleries, and in libraries. Is this a good argument for multiculturalism? I propose to examine not only its validitybutits assumptions and what impels diese multiculturalists to make it. Is there such a thing as intrinsic merit? A famous and influential argument that there is—W K. Wimsatt and Monroe C. Beardsley's "The Affective Fallacy" (1949)—argues that the merit (or lack of merit) of literature, and by extension the other arts, is intrinsic. Actually—what comes to much the same thing—this essay attacks die belief that merit is extrinsic, in particular that it inheres in effects upon readers. The Affective Fallacy, they claim, "is a confusion between the poem [where poem is synecdoche for work of literature] and its results (what it is and Philosophy and Literature, © 1994, 18: 253-264 254Philosophy and Literature what it does).... It begins by trying to derive die standards of criticism from the psychological effects of the poem and ends in impressionism and relativism." The standards ofcriticism ought to be derived, Wimsatt and Beardsley say, from "cognitive analysis ofparadox, ambiguity, irony, and symbol"—that is, intrinsic features of the poem itself. Are Wimsatt and Beardsley right? I think not. For one tiling, the weight of opinion, of both critics and writers, is against diem. For Aristode, the point of a tragedy was to arouse pity and fear in the audience. For Horace, die point of poetry was to please and instruct readers (dulce et utile). For Dickens, die point of his novels was to make readers laugh and cry. For Henry James, every choice he made as a novelist—of characters, incidents, setting, point ofview—he made widi effects upon readers in mind. Even for Romantic poets, diough die merit of a poem did not lie in its effects upon readers, it did not lie in its intrinsic features either, but in its effects upon the poet himself (for Wordswordi, occasioning "die spontaneous overflow of powerful feelings "). Indeed, not until the advent, in the late thirties, of the school of which Wimsatt and Beardsley were die chief theoreticians—die New Criticism—did critics locate merit in intrinsic features. Critics and writers, of course, often speak of intrinsic features but only, as James does, to relate them to somediing extrinsic. Aristode, for instance, says diat a tragedy can arouse pity and fear only if its hero is a person of middling virtue who undeservedly goes from good fortune to bad in die course of the play. Books of literature are created by humans for humans, and whatever merit (or lack of merit) they may have humans confer upon them. Far from being an intrinsic merit, paradox or ambiguity or irony or symbol or any intrinsic feature of a work is no merit at all unless readers count it as a merit; readers may disagree about whether it is a merit (the relativism thatWimsatt and Beardsley deplore) ; every standard to which diey may appeal to settle disputes is a standard created by humans; and they may have various reasons for counting it as a merit (or a defect). The most common reason, of course, commits the Affective Fallacy: the feature affects readers in a way they find desirable. (As I shall note later, in section III, diere can be other reasons less direcdy related to the effect of the work.) It is not easy for readers (or theorists of literary value) to sayjust what die effect is ofan intrinsic feature or why readers count this effect as desirable or even what feature of the work causes this effect. But, though Wimsatt and Beardsley, in arguing dieir case for the Affective Fallacy, make... (shrink)

In developing a framework for assessing privacy risks, Dupras and Bunnik’s “Toward a framework for assessing privacy risks in multi-omic research and databases” considers the question of whe...

La mente non è sempre esistita ma è stata inventata: inventata nel senso che, a un certo punto, qualcuno ha introdotto il concetto di mente. Chi lo abbia introdotto per primo è una questione controversa. Per esempio, Putnam a f f er ma c he , a nc he s e «i n que s t os e c ol os i pa r l a c ome s e l a me nt e f os s e qua s (...) i un’ i de a autoevidente», nondimeno la nozione attuale di mente «non è molto antica, o almeno la sua Ce r t o, «l e pa r ol e ‘ me nt e ’ e ‘ a ni ma ’ , o a l me no i l or o a nt e na t i egemonia non è molto antica».1.. (shrink)

The article compares Pope Francis's encyclical “LAUDATO SI” (2015) and the report by the Club of Rome, “”ome On!: Capitalism, Short-termism, Population and the Destruction of the Planet” (2018), in how they harness the narrative potential of the concept of home. Both with overtly religious and entirely secular arguments, the narrative of our common home is presented as a possible alternative to the prevailing narrative of growth today. The metaphor of home possesses not only conceptual but also generative power to (...) offer concrete solutions to two of humanity's most pressing issues today: the problem of waste and the problem of climate change. The narrative of home activates the power of local places while simultaneously seeking global balance on a worldwide scale. The study focuses on how the narrative of home transforms the relationship with places and the balance between the local and the global. (shrink)

Lucid dreams are dreams in which a person becomes aware that they are dreaming. They are different from ordinary dreams, not just because of the dreamer's awareness that they are dreaming, but because lucid dreams are often strikingly realistic and may be emotionally charged to the point of elation. Celia Green and Charles McCreery have written a unique introduction to lucid dreams that will appeal to the specialist and general reader alike. The authors explore the experience of lucid dreaming, relate (...) it to other experiences such as out-of-the-body experiences and apparitions, and look at how lucid dreams can be induced and controlled. They explore their use for therapeutic purposes such as counteracting nightmares. Their study is illustrated throughout with many case histories. (shrink)

Following the rediscovery of Mendelian genetics, food supply pressures and the rapid expansion of crop varieties with defined performance characteristics, international systems were set up throughout the 20 C to regulate the trade of seed, the protection of intellectual property and the sale of productive varieties of key agricultural crops. These systems are a highly connected but largely linear set of processes. System changes are slow to be adopted due to the cascade of effects that structural alteration would have globally. (...) Multi-omic technologies and the subsequent proliferation of data types used within modern breeding, offer the possibility to gain deeper insights into the performance characteristics of varieties. Current integration of data, standards and ownership structures limit their applications for wider purposes, both private and public. We explore how data within and between breeding programmes and the varietal approval and monitoring processes could be made FAIR. We examine what role expanded or aligned programmes of data collection and expanded trait evaluation at the point of varietal registration and evaluation, as well as on farm could have in ensuring the best linkage of public and private data to address some of the challenges society faces over the next 30 years with the required, rapid transition to sustainable agricultural systems. (shrink)

In this article I argue that the dominant discourse of our day is econ omic universalism. This has translated comfortably from modernity to postmodernity. Within this discourse real differences and inequalities are homogenized by narratives such as those of choice and diversity. I shall question this in two ways: first, by borrowing from French post- structuralism to rename the discourse a 'masculine economy', and thus to invoke a 'feminine economy' both as a philosophical structure of difference and as a deliberate (...) introduction of the body; second, by analysing economic narratives concerning women's work which tend to flatten out difference altogether or recast it as (well-advised) choice. Within this economic language game, I shall try to emphasize material differences and inequalities, in other words, I shall borrow from the language of opposition. I claim that only the asymmetrical oscillation between difference and opposition can attempt to prevent either one falling back into some kind of more or less comfortable universalism. (shrink)

Personalized Medicine is an evolving and often missinterpreted concept and no agreement of personalization exist. We examined the PM discourse towards foucauldian archeological and genealogical analysis to understand the meaning of “personalization” in medicine. In the archaeological analysis, the historical evolution is characterized by the coexistence of two epistemologies: the holistic vision and the omic sciences. The genealogical analysis shows how these epistemologies may affect the meaning of “person” and, consequently, the ontology of patients. Additionally, substitutions/confusions of the term PM (...) are related to continuously evolving medical knowledge and new technologies; different etymological roots of “personalization” and “person”; and cultural differences. In conclusion, if the definition of “personalization” in medicine is not clear, patients might get wrong expectations about what is achievable for their health. Therefore, epistemological trends should not be separated as they drive same goals: providing accurate diagnosis and treatments based on large data to predict disease progression. (shrink)

Integration of knowledge concerning circadian rhythms, metabolic networks, and sleep‐wake cycles is imperative for unraveling the mysteries of biological cycles and their underlying mechanisms. During the last decade, enormous progress in circadian biology research has provided a plethora of new insights into the molecular architecture of circadian clocks. However, the recent identification of autonomous redox oscillations in cells has expanded our view of the clockwork beyond conventional transcription/translation feedback loop models, which have been dominant since the first circadian period mutants (...) were identified in fruit fly. Consequently, non‐transcriptional timekeeping mechanisms have been proposed, and the antioxidant peroxiredoxin proteins have been identified as conserved markers for 24‐hour rhythms. Here, we review recent advances in our understanding of interdependencies amongst circadian rhythms, sleep homeostasis, redox cycles, and other cellular metabolic networks. We speculate that systems‐level investigations implementing integrated multi‐omics approaches could provide novel mechanistic insights into the connectivity between daily cycles and metabolic systems. -/- . (shrink)

This grounded study investigated the negotiation of authorship by faculty members, graduate student mentors, and their undergraduate protégés in undergraduate research experiences at a private research university in the northeastern United States. Semi-structured interviews using complementary scripts were conducted separately with 42 participants over a 3 year period to probe their knowledge and understanding of responsible authorship and publication practices and learn how faculty and students entered into authorship decision-making intended to lead to the publication of peer-reviewed technical papers. Herein (...) the theoretical model for the negotiation of authorship developed through the analysis of these interviews is reported. The model identifies critical causal and intervening conditions responsible for the coping strategies faculty and students employ, which, in our study, appear to often produce unfortunate consequences for all involved. The undergraduate student researchers and their graduate student mentors interviewed in this study exhibited a limited understanding of authorship and the requirements for authorship in their research groups. The power differential between faculty and students, the students’ limited epistemic development, the busy-ness of the faculty, and the faculty’s failure to prioritize authorship have been identified as key factors inhibiting both undergraduate and graduate students from developing a deeper understanding of responsible authorship and publication practices. Implications for graduate education and undergraduate research are discussed, and strategies for helping all students to develop a deeper understanding of authorship are identified. (shrink)

Abstract:Artificial intelligence is profoundly transforming the world in various spheres and already finding its way into educational institutions. This essay aims to examine whether the Deweyan ideal of education can be achieved through such digital means. By analyzing how both the aims and means of education, as defined by Dewey, can be understood in the context of learning with artificial intelligence, the inherent differences of both educational approaches are brought out. It becomes apparent that important concepts that characterize successful education (...) for Dewey, such as intrinsic inquiry, experience-based schooling, and thinking as the method for learning, do not go hand in hand with intelligent teaching systems. (shrink)

Trust is a topic of longstanding philosophical interest. It is indispensable to every kind of coordinated human activity, from sport to scientific research. Even more, trust is necessary for the successful dissemination of knowledge, and by extension, for nearly any form of practical deliberation and planning. Without trust, we could achieve few of our goals and would know very little. Despite trust’s fundamental importance in human life, there is substantial philosophical disagreement about what trust is, and further, how trusting is (...) normatively constrained and best theorized about in relation to other things we value. This entry is divided into three sections, which explore key (and sometimes interconnected) ethical and epistemological themes in the philosophy of trust: (1) The Nature of Trust; (2) The Normativity of Trust, and (3) The Value of Trust. (shrink)

Dynamic Epistemic Logic This article tells the story of the rise of dynamic epistemic logic, which began with epistemic logic, the logic of knowledge, in the 1960s. Then, in the late 1980s, came dynamic epistemic logic, the logic of change of knowledge. Much of it was motivated by puzzles and paradoxes. The number … Continue reading Dynamic Epistemic Logic →.