Recent studies suggest that insects use pattern recognition molecules to distinguish prokaryotic pathogens and fungi from “self” structures. Less understood is how the innate immune system of insects recognizes endoparasitic Hymenoptera and other eukaryotic invaders as foreign. Here we discuss candidate recognition factors and the strategies used by parasitoids to overcome host defense responses. We suggest that host–parasitoid systems are important experimental models for studying how the innate immune system of insects recognizes foreign invaders that are phylogenetically more (...) closely related to their hosts. The strategies used by parasitoids suggest that insects may employ “hidden-self” recognition molecules for attacking foreign objects intruding the open circulatory system. BioEssays 23:344–351, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Antigen presentation to CD8+ T cells by MHC class I molecules is essential for host defense against viral infections. Various mechanisms have evolved in multiple viruses to escape immune surveillance and defense to support viral proliferation in host cells. Through in vitro SARS‐CoV‐2 infection studies and analysis of COVID‐19 patient samples, we found that SARS‐CoV‐2 suppresses the induction of the MHC class I pathway by inhibiting the expression and function of NLRC5, a major transcriptional regulator of MHC class I (...) genes. In this review, we discuss the molecular mechanisms for suppression of the MHC class I pathway and clinical implications for COVID‐19. (shrink)

Study of the multiplicity of interactions between invertebrate hosts and their parasites helps to define the aspects of the host immune systems that have ecological and evolutionary significance. Such study, however, reveals how much is yet unknown. For instance, the costs of mounting an immune response, the nature of the long-lasting protection sometimes attained, and the high degree of specificity observed in certain hosts are phenomena that still await full explanation. An additional puzzle is the high degree of (...) specificity achieved in light of the apparent low degree of specificity in the recognition and effector mechanisms of insect immune systems. Furthermore, while protective immunity is typically associated with vertebrate adaptive immune systems, invertebrates may have analogous capacities, whose nature is still largely unknown. This review will illustrate how the traditional host-centred view of immune defence can be usefully extended by taking account of parasite immune evasion strategies and the variation that such strategies create in the observed outcomes of infection. BioEssays 27:1026–1034, 2005. © 2005 Wiley Peiodicals, Inc. (shrink)

We highlight the various domains of the flavivirus virulence factor NS1 and speculate on potential implications of the NS1 3D structure in understanding its role in flavivirus pathogenesis. Flavivirus non‐structural protein 1 (NS1) is a virulence factor with dual functions in genome replication and immune evasion. Crystal structures of NS1, combined with reconstructions from electron microscopy (EM), provide insight into the architecture of dimeric NS1 on cell membranes and the assembly of a secreted hexameric NS1‐lipid complex found in (...) patient sera. Three structural domains of NS1 likely have distinct roles in membrane association, replication complex assembly, and immune system avoidance. A conserved hydrophobic inner face is sequestered either on the membrane or in the interior of the secreted hexamer and contains regions implicated in viral replication. The exposed variable outer face is presented to cellular and secreted components of the immune system in infected patients and contains candidate regions for immune system modulation. We anticipate that knowledge of the distinct NS1 domains and assembly will lead to advances in elucidating virus‐host interactions mediated through NS1 and in dissecting the role of NS1 in viral genome replication. (shrink)

An immunizing strategy is an argument brought forward in support of a belief system, though independent from that belief system, which makes it more or less invulnerable to rational argumentation and/or empirical evidence. By contrast, an epistemic defense mechanism is defined as a structural feature of a belief system which has the same effect of deflecting arguments and evidence. We discuss the remarkable recurrence of certain patterns of immunizing strategies and defense mechanisms in pseudoscience and other belief systems. Five different (...) types will be distinguished and analyzed, with examples drawn from widely different domains. The difference between immunizing strategies and defense mechanisms is analyzed, and their epistemological status is discussed. Our classification sheds new light on the various ways in which belief systems may achieve invulnerability against empirical evidence and rational criticism, and we propose our analysis as part of an explanation of these belief systems’ enduring appeal and tenacity. (shrink)

Beginning with an exemplary case study, this paper diagnoses and analyses some important strategies of evasion and factors of hindrance that are met in the teaching of medical ethics to undergraduate medical students. Some of these inhibitions are inherent to ethical theories; others are connected with the nature of medicine or cultural trends. It is argued that in order to avoid an attitude of evasion in medical ethics teaching, a philosophical theory of emotions is needed that is able (...) to clarify on a conceptual level the ethical importance of emotions. An approach is proposed with the help of the emotion theory Martha Nussbaum works out in her book Upheavals of thought. The paper ends with some practical recommendations. (shrink)

I argue that immunity to error through misidentification primarily characterizes thoughts that are 'implicitly' de se, as opposed to thoughts that involve an explicit self-identification. Thoughts that are implicitly de se involve no reference to the self at the level of content: what makes them de se is simply the fact that the content of the thought is evaluated with respect to the thinking subject. Or, to put it in familiar terms : the content of the thought is a property (...) which the thinking subject self-ascribes (as in the Loar/Lewis/Chisholm analysis). After answering an objection (to the effect that immunity can affect explicit de se thoughts), I extend the analysis to demonstrative thoughts, which also exhibit the property of immunity to error through misidentification. (shrink)

In Immunity, Alfred Tauber sets forth a new theory of immunology that rejects the common principle of self and non-self, and the immune system's role as a protector of the self from external threats. Rather than serving to defend an independent entity, he argues, immunity participates in a large, complex eco-system of porous and flexible boundaries. Tauber's new approach to immunology necessitates a new biology in which symbiosis is the rule, not the exception.

In their recent article, Brown et al analyse several ethical aspects around immunity passports and put forward some recommendations for implementing them. Although they offer a comprehensive perspective, they overlook two essential aspects. First, while the authors consider the possibility that immunological passports may appear to discriminate against those who do not possess them, the opposite viewpoint of immune people is underdeveloped. We argue that if a person has been tested positive for and recovered from COVID-19, becoming immune (...) to it, she cannot be considered a hazard to public health and, therefore, the curtailment of her fundamental rights is not legitimate. Second, they omit that vaccine distribution will create similar problems related to immunity-based licenses. Vaccine certificates will de facto generate a sort of immunity passport. In the next phases of the pandemic, different immunity statuses will be at stake, because the need to identify who can spread COVID-19 is unavoidable. If a person does not pose a threat to public health because she cannot spread the infection, then her right to freedom of movement should be respected, regardless of how she acquired that immunity. (shrink)

In this collection of newly commissioned essays, the contributors present a variety of approaches to it, engaging with historical and empirical aspects of the subject as well as contemporary philosophical work.

Intended both as an introduction to the thought of the Italian philosopher Roberto Esposito and as a mapping of current biopolitical practice, this essay traces the contributions and the limits of recent Italian contributions to the discussion of biopolitics. The essay offers a summary of Esposito's insight into the relation of community and immunity and compares his thinking to other philosophers who take immunity as their object of study . Campbell goes on to read Esposito's privileging of bios in the (...) light of Giorgio Agamben's emphasis on zōē, while making reference as well to Antonio Negri and Michael Hardt's understanding of biopower. He concludes by arguing that the stakes of Esposito's analysis for an affirmative biopolitics concern fundamentally the nature of community and its opening to all life forms as bios. (shrink)

In this paper I aim to illuminate the significance of thought insertion for debates about the first-person concept. My starting point is the often-voiced contention that thought insertion might challenge the thesis that introspection-based self-ascriptions of psychological properties are immune to error through misidentification relative to the first-person concept. In the first part of the paper I explain what a thought insertion-based counterexample to this immunity thesis should be like. I then argue that various thought insertion-involving scenarios do not (...) give rise to successful counterexamples to the immunity of the target class of self-ascriptions. In the second part of the paper I turn to defend a Metasemantic Explanation of why the immunity thesis holds. The Metasemantic Explanation rests on a reference-fixing story about the mental ‘I’ whose key contention is that introspective impressions play an essential role in fixing its reference. It is part of my argument in favour of the proposed reference-fixing story, as well as of the Metasemantic Explanation, that they respect the paradigmatic features of self-ascriptions of inserted thoughts. (shrink)

Adaptive immunity provides the unique ability to respond to a nearly infinite range of antigenic determinants. Given the inherent plasticity of the adaptive immune system, a series of tolerance mechanisms exist to reduce reactivity toward self. While this reduces the probability of autoimmunity, it also creates an important gap in adaptive immunity: the ability to recognize microbes that look like self. As a variety of microbes decorate themselves in self‐like carbohydrate antigens and tolerance reduces the ability of adaptive immunity (...) to react with self‐like structures, protection against molecular mimicry likely resides within the innate arm of immunity. In this review, we will explore the potential consequences of microbial molecular mimicry, including factors within innate immunity that appear to specifically target microbes expressing self‐like antigens, and therefore provide protection against molecular mimicry. (shrink)

Any plausible position in the ethics of war and political violence in general will include the requirement of protection of civilians (non-combatants, common citizens) against lethal violence. This requirement is particularly prominent, and particularly strong, in just war theory. Some adherents of the theory see civilian immunity as absolute, not to be overridden in any circumstances whatsoever. Others allow that it may be overridden, but only in extremis. The latter position has been advanced by Michael Walzer under the heading of (...) “supreme emergency.” In this paper, I look into some of the issues of interpretation and application of Walzer’s “supreme emergency” view and some of the criticisms that have been levelled against it. I argue that Walzer’s view is vague and unacceptable as it stands, but that the alternatives proposed by critics such as Brian Orend, C.A.J. Coady, and Stephen Nathanson are also unattractive. I go on to construct a position that is structurally similar to Walzer’s, but more specific and much less permissive, which I term the “moral disaster” view. According to this view, deliberate killing of civilians is almost absolutely wrong. (shrink)

This article is concerned with an exploration of a family of systems—called immune logics—that arise from certain dualizations of the well-known family of infectious logics. The distinctive feature of the semantic of infectious logics is the presence of a certain “infectious” semantic value, by which two different though equivalent things are meant. On the one hand, it is meant that these values are zero elements for all the operations in the underlying algebraic structure. On the other hand, it is (...) meant that these values behave in a value-in-value-out fashion for all the operations in the underlying algebraic structure. Thus, in a rather informal manner, we will refer to immune logics as those systems whose underlying semantics count with a certain “immune” semantic value behaving in a way that is somewhat dual to that of the infectious values. In a more formal manner, carrying out this dualization will prove to be not as straightforward as one could imagine, since the two characterizations of infectiousness discussed above lead to two different outcomes when one tries to conduct them. We explore these alternatives and provide technical results regarding them, and the various logical systems defined using such semantics. (shrink)

El taekwondo como arte marcial y disciplina siempre ha sido un medio para garantizar la construcción de personas seriales que toman en cuenta la práctica del respeto y los valores (más allá de la efectividad y el rendimiento deportivos), desde una lógica orientada a constituirlas como líderes en situaciones multidisciplinarias. Uno de los enclaves más comunes que se derivan de su aprendizaje es la perseverancia, que es de importancia para enfrentar las adversidades cotidianas y concretizar proyectos. De allí, es que (...) la paciencia y la contribución consuetudinarias por esa formación suscitan un aval de que se patentizarán esos intereses anhelados. Otro aditamento es la configuración de personas que procuran articular una ideología humanizadora, en la que se muestran igualdad y democracia en la metrópoli. Sin embargo, a la cultura latinoamericana dictatorial (recurro a esta calificación pertinente por apreciarse en estos países disconformidad política, fomento de la corrupción, abusos de poder, crímenes y violaciones a los derechos humanos), no le conviene que existan ciudadanos de esa índole, así como intelectuales que critican las irregularidades de su sistema, porque prevalece un requerimiento implícito por no educar y solo recompensar cuando se aprecian logros inmediatos y cualitativos sin considerar la procedencia. Ante ello, el propósito de esta investigación cuestiona la importancia real que el Estado latinoamericano otorga a los practicantes de taekwondo, siendo sus acciones y sus resultados los que integrarán una representación eficaz que la cultura pretenda imitar para que, de esa forma, se consiga una sociedad democrática, competitiva y transparente. (shrink)

Behavioral immune system describes psychological mechanisms that detect cues to infectious pathogens in the immediate environment, trigger disease-relevant responses and facilitate behavioral avoidance/escape. BIS activation elicits a perceived vulnerability to disease which can result in conformity with social norms. However, a response to superficial cues can result in aversive responses to people that pose no actual threat, leading to an aversion to unfamiliar others, and likelihood of prejudice. Pathogen-neutralizing behaviors, therefore, have implications for social interaction as well as illness (...) behaviors and responses to health communications. In this study, we investigate how PVD influences conformity, attitudes to other people and to lockdown regulations through the lens of the Reinforcement Sensitivity Theory. RST describes personality in terms of biologically-driven approach and avoidance motivations which support personal goals. Participants from the United Kingdom public completed an RST personality questionnaire and then read either coronavirus morbidity-mortality statistics and current United Kingdom government lifestyle regulations, just the regulations, or no information at all. They all completed the Perceived Vulnerability to Disease scale to assess BIS-relevant Germ Aversion and Perceived Infectability, followed by questions measuring social conformity, warmth toward others and attitudes toward lockdown measures. Significantly lower PVD scores were observed in the no-information condition, with the other conditions showing no difference. In terms of RST, approach behaviors related to goal-drive persistence work alongside fear in explaining conformity to social norms. Reward related approach behaviors partially explained warmth toward others, indicating that social rewards gained through interaction continue to be strong drivers of behavior. We found no role for RST traits in attitudes toward lockdown. Overall, coronavirus-related behavior is not driven purely by fear, but also by social and/or protection goals regulated by approach motivation. This study presents new insights into public perceptions of coronavirus and government regulated lifestyle restrictions, helping to explain social behaviors in terms of biologically driven mechanisms. Such understanding is vital if we are to successfully motivate public behavior to constrain spread of the virus. (shrink)

Taking Emerson as his starting point, Cornel West’s basic task in this ambitious enterprise is to chart the emergence, development, decline, and recent resurgence of American pragmatism. John Dewey is the central figure in West’s pantheon of pragmatists, but he treats as well such varied mid-century representatives of the tradition as Sidney Hook, C. Wright Mills, W. E. B. Du Bois, Reinhold Niebuhr, and Lionel Trilling. West’s "genealogy" is, ultimately, a very personal work, for it is imbued throughout with the (...) author’s conviction that a thorough reexamination of American pragmatism may help inspire and instruct contemporary efforts to remake and reform American society and culture. "West... may well be the pre-eminent African American intellectual of our generation."—The Nation "_The American Evasion of Philosophy_ is a highly intelligent and provocative book. Cornel West gives us illuminating readings of the political thought of Emerson and James; provides a penetrating critical assessment of Dewey, his central figure; and offers a brilliant interpretation—appreciative yet far from uncritical—of the contemporary philosopher and neo-pragmatist Richard Rorty.... What shines through, throughout the work, is West's firm commitment to a radical vision of a philosophic discourse as inextricably linked to cultural criticism and political engagement."—Paul S. Boyer, professor emeritus of history, University of Wisconsin–Madison. Wisconsin Project on American Writers Frank Lentricchia, General Editor. (shrink)

Are bodily self-ascriptions immune to error through misidentification? According to the Inside mode view, one cannot be mistaken about whose body part it is when experiencing them from the inside. Here I shall consider two possible objections to bodily immunity. On the one hand, I shall briefly envisage two cases of misidentification: somatoparaphrenia and the Rubber Hand illusion. I shall show that none of them challenges the immunity principle. On the other hand, I shall highlight a more serious issue (...) for bodily immunity, namely, the multimodal nature of bodily self-knowledge. Very few bodily self-ascriptions are based on grounds that are purely or exclusively from the inside. I shall evaluate the consequences of multimodality for bodily immunity. (shrink)

Autobiographical memories typically give rise either to memory reports (“I remember going swimming”) or to first person past-tense judgements (“I went swimming”). This article focuses on first person past-tense judgements that are (epistemically) based on autobiographical memories. Some of these judgements have the IEM property of being immune to error through misidentification. This article offers an account of when and why first person past-tense judgements have the IEM property.

This is one of the first books in a new series that will publish the very best work in the philosophy of biology. The series will be non-sectarian in character, will extend across the broadest range of topics, and will be genuinely interdisciplinary. The Immune Self is a critical study of immunology from its origins at the end of the nineteenth century to its contemporary formulation. The book offers the first extended philosophical critique of immunology, in which the function (...) of the term 'self' that underlies the structure of current immune theory is analysed. However, this analysis is carefully integrated into a broad survey of the major scientific developments in immunology, a discussion of their historical context, and a review of the conceptual arguments that have moulded this sophisticated modern science. (shrink)

This is one of the first books in a new series that will publish the very best work in the philosophy of biology. The series will be non-sectarian in character, will extend across the broadest range of topics, and will be genuinely interdisciplinary. The Immune Self is a critical study of immunology from its origins at the end of the nineteenth century to its contemporary formulation. The book offers the first extended philosophical critique of immunology, in which the function (...) of the term 'self' that underlies the structure of current immune theory is analysed. However, this analysis is carefully integrated into a broad survey of the major scientific developments in immunology, a discussion of their historical context, and a review of the conceptual arguments that have moulded this sophisticated modern science. (shrink)

Artificial Immune Systems (AIS) are intelligent algorithms derived on the principles inspired by human immune system. In this research work, electroencephalography (EEG) signals for four distinct motor movement of human limbs are detected and classified using Negative Selection Classification Algorithm (NSCA). For this study, a widely studied open source EEG signal database (BCI IV - Graz dataset 2a, comprising 9 subjects) has been used. Mel Frequency Cepstral Coefficients (MFCCs) are extracted as selected feature from recorded EEG signals. Dimensionality (...) reduction of data is carried out by applying two hidden layered stacked auto-encoder. Genetic Algorithm (GA) optimized detectors (Artificial Lymphocytes) are trained using Negative Selection Algorithm (NSA) for detection and classification of four motor movements. The trained detectors consist of four sets of detectors, each set is trained for detection and classification of one of the four movements from the other three movements. The optimized radius of detector is small enough not to mis-detect the sample. Euclidean distance of each detector with every training dataset sample is taken and compared with optimized radius of detector as a non-self detector. Our proposed approach achieved a mean classification accuracy of 86.39% for limb movements over 9 subjects with a maximum individual subject classification accuracy of 97.5 % for subject number eight. (shrink)

In the following excerpt from Bios, Esposito sketches the template of immunity as a response to what he calls a "hermeneutic block" in Foucault's notion of biopolitics. After singling out those moments of greatest tension in Foucault's reading of biopolitics especially as it relates to Nazi thanatopolitics, Esposito sets out in detail the most important features of what he calls the immunization paradigm. Consisting of three dispositifs, namely sovereignty, property, and liberty, the immunitary paradigm has for Esposito a decisively modern (...) inflection. Indeed modern biopolitics cannot be thought apart from the mode by which communities immunize or protect themselves. (shrink)

Da Ré and Szmuc argue that while there is a symmetry between ‘infectious’ and ‘immune’ logics, this symmetry fails w.r.t. extending an algebra with an immune or an infectious element. In this paper, I show that the symmetry also fails w.r.t. defining a new logical operation from a given set of primitive (Boolean) operations. I use the case of the material conditional to illustrate this point.

Using an economic bargaining game, we tested for the existence of two phenomena related to social norms, namely norm manipulation – the selection of an interpretation of the norm that best suits an individual – and norm evasion – the deliberate, private violation of a social norm. We found that the manipulation of a norm of fairness was characterized by a self-serving bias in beliefs about what constituted normatively acceptable behaviour, so that an individual who made an uneven bargaining (...) offer not only genuinely believed it was fair, but also believed that recipients found it fair, even though recipients of the offer considered it to be unfair. In contrast, norm evasion operated as a highly explicit process. When they could do so without the recipient's knowledge, individuals made uneven offers despite knowing that their behaviour was unfair. (shrink)

A self-ascription is a thought or sentence in which a predicate is self-consciously ascribed to oneself. Self-ascriptions are best expressed using the first-person pronoun. Mental self-ascriptions are ascriptions to oneself of mental predicates (predicates that designate mental properties), non-mental self-ascriptions are ascriptions to oneself of non-mental predicates (predicates that designate non-mental properties). It is often claimed that there is a range of self-ascriptions that are immune to error through misidentification relative to the first-person pronoun (IEM for short). What this (...) means, and exactly which self-ascriptions are properly classed as IEM, is a topic hotly disputed. Some claim that only mental self-ascriptions are IEM, others claim that some non-mental self-ascriptions are IEM. Before this question can be decided, it needs to be judged exactly what it means to say that a self-ascription is IEM. And here we stumble across the fact that there are, at least, two non-equivalent ways of defining the phenomenon1. I will be claiming that one of these definitions should be rejected. (shrink)

In this article, Roberto Esposito lays out the genealogical pathways linking the three major concepts around which his most recent work has wound its way: community, immunity, and biopolitics. Although immunity is necessary to the preservation of our life, when driven beyond a certain threshold it forces life into a sort of cage where not only our freedom gets lost but also the very meaning of our existence – that opening of existence outside itself that takes the name of communitas. (...) A hermeneutics informed by immunity can allow the category of community to regain a new political significance, without ending up in a substantialist metaphysics. This task is dictated by the urgent need for an affirmative biopolitics – a horizon of meaning – in which life would no longer be the object but somehow the subject of politics. But what sort of shape would this take? Where would we trace its symptoms? And with what objectives? A preliminary answer focuses on breaking the vise grip between public and private that threatens to crush the common, by seeking instead to expand the space of the common, in the fight, for example, against the planned privatization of water and the battle over energy sources. (shrink)

Immune cells are highly dynamic in their response to the tissue environment. Most immune cells rapidly change their metabolic profile to obtain sufficient energy to engage in defensive or homeostatic processes. Such “immunometabolism” is governed through intermediate metabolites, and has a vital role in regulating immune‐cell function. The underlying metabolic reactions are shaped by the abundance and accessibility of specific nutrients, as well as the overall metabolic status of the host. Here, we discuss how different immune‐cell (...) types gain a sufficient energy supply. We then explain how immune cells perform various functions under challenged conditions and expend energy to sustain homeostasis. Finally, we speculate on how the immune‐cell metabolic profile might be modulated in health and disease, by manipulating nutrient availability. By such intervention, the recovery of patient with dysregulated immune system responses might be sped up and the fitness of an individual efficiently restored. (shrink)

In recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive immune system. Particularly the discovery of CRISPR-Cas9-based systems has triggered a discussion about how to classify adaptive immune systems. One question that has not been addressed yet is the transgenerational aspect of the CRISPR-Cas9-based response. If immunity is acquired and inherited, how to distinguish evolutionary from immunological adaptation? (...) To shed light on this issue and obtain conceptual clarity, I will investigate the inheritance of small RNA responses to pathogens in the nematode C. elegans as a further potential instantiation of a transgenerational adaptive immune system. I will explore how to make sense of systems that lie at the crossroads between genetic, immunological, and evolutionary spheres and explore the consequences of a transgenerational perspective on immune systems for immunology and its philosophy. (shrink)

In the fight against racism, philosophy has to interrogate caste in its own histories and current decolonial consensus. Caste has been evading its interrogation as the oldest race theory and racist practice, which continue to oppress the lower-caste peoples who constitute the majority population of the Indian subcontinent. Caste and race are species of the hypophysics of man, which consecrates scaled intrinsic value in human nature through the notion of “being born as” by “being born to.” They are analogues in (...) having the same denigrate-dominate function of exploiting by including as born inferior. However, caste and race are also homologues since the hypophysics of caste has been at the origins of the hypophysics of race from at least the eighteenth century, culminating in the “Aryan doctrine” of the Nazis, now being revived. Caste was the empirical, conceptual, and textual resource for Europeans as it showed that large groups could be dominated as well as excluded through the self-designated superiority, supplied by the Brahminical texts, of the oppressing group. Rather than a colonial construct, caste is the oldest racism, which in colonial times devised new calypsologies—ways to mask itself against rising anticaste thought and politics. Postcolonial and subaltern theories disguise caste’s racism as “religion,” “culture,” and subaltern subjectivity, while some sociologists have denigrated Dalit scholarship as unacademic and emotional. The homologies of caste are still dangerously regnant today. (shrink)

Say that a function π:n<ω→n (henceforth called a predictor) k-constantly predicts a real xnω if for almost all intervals I of length k, there is iI such that x(i)=π(x↾i). We study the k-constant prediction number vnconst(k), that is, the size of the least family of predictors needed to k-constantly predict all reals, for different values of n and k, and investigate their relationship.

In this contribution, we address the issues concerning the semantic value of Wittgenstein’s subject “I”, as in “I have a toothache”, resulting from the use of predicates that involve first-person knowledge of the mental states to which they refer. As is well-known, these contexts give rise to the phenomenon of ‘immunity to error through misidentification’ : the utterer of cannot be mistaken as to whether he is the person having a toothache. We provide a series of arguments in favor of (...) a principled distinction between a de facto IEM, grounded in perceptual and proprioceptive judgments, and a de iure IEM, grounded in experience reports whereby the experience wears the experiencer on its sleeve. From this perspective, the no-referent account of subject “I” advocated by Wittgenstein/Anscombe is correct. In fact, we show how this analysis can be made compatible with a Kaplanian account of first-person indexicals, by identifying the speaker in the context of utterance with the person who has access to the reported private experience. (shrink)

Host‐pathogen arms race is a universal, central aspect of the evolution of life. Most organisms evolved several distinct yet interacting strategies of anti‐pathogen defense including resistance to parasite invasion, innate and adaptive immunity, and programmed cell death (PCD). The PCD is the means of last resort, a suicidal response to infection that is activated when resistance and immunity fail. An infected cell faces a decision between active defense and altruistic suicide or dormancy induction, depending on whether immunity is “deemed” capable (...) of preventing parasite reproduction and consequent infection of other cells. In bacteria and archaea, immunity genes typically colocalize with PCD modules, such as toxins‐antitoxins, suggestive of immunity‐PCD coupling, likely mediated by shared proteins that sense damage and “predict” the outcome of infections. In type VI CRISPR‐Cas systems, the same enzyme that inactivates the target RNA might execute cell suicide, in a case of ultimate integration of immunity and PCD. (shrink)

" Le besoin d'évasion écrit Emmanuel Lévinas, nous conduit au cœur de la philosophie. Il nous permet de renouveler l'antique problème de l'être en tant qu'être... " C'est dore que, dans ce texte, il choisit - à la faveur d'un thème fortement heideggerien - d'aller à la rencontre des questions qui, toujours, ont guidé sa quête : le besoin d'évasion n'est-il pas le propre d'un être fini? N'aspire-t-il pas à franchir les limites de l'être plutôt qu'à le fuir? Et pourquoi (...) l'être aurait-il besoin de sortir de soi? Sur tous ces points, la méditation d'Emmanuel Lévinas s'affirme ici souveraine et féconde. A s'y engager, tout lecteur se rapprochera de la vérité de son destin au cœur d'une modernité tragique et opaque. (shrink)

Cancer cells seem to exploit mechanisms that evolve as part of physiological tolerance, which is a complementary and often beneficial form of defense. The study of physiological systems of tolerance can therefore provide insights into the development of a state of host tolerance of cancer, and how to break it. Analysis of these models has the potential to improve our understanding of existing immunological therapeutic targets, and help to identify future targets and rational therapeutic combinations. The treatment of cancer with (...) immune checkpoint inhibitors aims to reverse the progression to tolerance of cancer, and achieve an immunogenic, rather than tolerogenic, homeostasis. Broadening the efficacy and durability of checkpoint inhibitors focuses on reversing tolerance and stimulating immunogenicity in the cancer, host, and environment. Two examples of important physiological states of tolerance that may inform tolerance of cancer are microbial infection and placental reproduction. These states of tolerance result from bilateral shaping of host and non‐self, akin to immunoediting in cancer, and offer reliable models to study the immune tolerance paradigm. (shrink)

We define and study a new notion called k-immunity that lies between immunity and hyperimmunity in strength. Our interest in k-immunity is justified by the result that θ does not k-tt reduce to a k-immune set, which improves a previous result by Kobzev [7]. We apply the result to show that Φ′ does not btt-reduce to MIN, the set of minimal programs. Other applications include the set of Kolmogorov random strings, and retraceable and regressive sets. We also give a (...) new characterization of effectively simple sets and show that simple sets are not btt-cuppable. (shrink)

It has long been taken for granted that the immune system’s capacity to protect an individual from infection and disease depends on the power of the system to distinguish between self and nonself. However, accumulating data have undermined this fundamental concept. Evidence against the self/nonself discrimination model left researchers in need of a new overarching framework able to capture the immune system’s reactivity. Here, I highlight that along with the self/nonself model, another powerful representation of the immune (...) system’s reactivity has been developed in the twentieth century immunology. According to this alternative view, the immune system is not a killer of nonself strangers but a peace-maker helping to establish harmony with the environment. The balance view of the system has never become part of the dominant paradigm. However, it is gaining more and more currency as new research develops. Advances in mucosal immunology confirm that instead of distinguishing between self and foreign the immune system reacts to microbial, chemical and self-induced alterations to produce responses that counterbalance effects of these changes. (shrink)

In Three Essays on the Theory of Sexuality, Freud rejects the notion of a biologically determined connection of instinct to object, a position which helps him avoid the designation of all variations from heterosexuality as either “degenerate” or “pathological.” However, the gender roles and relations commonly attributed to heterosexuality are already implicit in his understanding of sexual instinct and aim. Consequently, even variations from the normal sexual object and aim exemplify, on his interpretation, the clichéd hierarchical opposition of femininity and (...) masculinity. Freud’s theory of sexuality thus implies that the erotic bond is inevitably one of domination, and that the only possible human relation is one of subject to object, activity to passivity, whole to part, and owner to property. My primary intention in this paper is to explore, in Freud’s analysis of fetishism, traces of an alternate possibility to oppositional hierarchical gender roles and the negative forms of social relation that rely upon them. While Freud---in keeping with common opinion---characterizes sexual fetishism as a distinctly masculine phenomenon, the text also supports a more interesting interpretation: that the non-pathological fetishist evades the construction of gender in terms of sexual roles and that, consequently, fetishism can serve as a critique of Freud’s masculine model of sexual instinct and relation. (shrink)

It is widely apparent in our hyper-globalized world that the epistemologies, institutions, and practices underwriting it have reached a state of profound crisis. In the globalized world, everything is inevitably brought into proximity and correlation. Wars, natural disasters, climatic upheaval, nor political and economic turmoil, none of these can be effectively isolated, insulated, instituted, even immunized, as something apart, something that might be considered proper only to itself. This collected edition considers this crisis of the proper with a focus on (...) Italian political theorist Roberto Esposito’s work on community, immunity, and biopolitics. This collection introduces Esposito’s work to a wider English-speaking audience and provides many important contributions to the burgeoning scholarship on his political theory. Important international scholars working in this area examine and analyze his theory from a variety of perspectives, including those of biopolitics, feminism, political theory, the history of philosophy , property, community, and gift economies. The collection also includes previously untranslated essays by Esposito and Jean-Luc Nancy. This collection will be of interest to those just discovering Esposito and for those who are already familiar with his work. This book was originally published as a Special Issue of Angelaki: Journal of the Theoretical Humanities. (shrink)

The thesis addresses the issues of error through misidentification and immunity to error through misidentification in relation to the problem of the first person. First, it provides an explanation of error through misidentification. Secondly, it shows that there are two possible ways of understanding immunity to error through misidentification. It is then argued that the first understanding of immunity to error through misidentification leads to what is labelled "the trilemma about the self". That is to say, either we provide an (...) explanation of immunity to error through misidentification, but we subscribe to two contentious metaphysical views about the self-the Cartesian and the Idealist; or else we hold the view that the self is identical with a human being, but we have no explanation of immunity to error through misidentification. It is then shown that in order to solve the trilemma, a different understanding of immunity to error through misidentification must be offered. After discussing various possible understandings of immunity to error through misidentification, a sound account of it is finally provided. Moreover, it is shown how non-inferential, introspection-based mental self-ascriptions can comply with it, in such a way that they turn out to be logically immune to error through misidentification. Finally, by drawing on Evans' and Peacocke's accounts of the possession conditions of the first person concept-in which IEM I-judgements play a central role-, it is shown that it is a concept of a human being who thinks of herself as such. Hence, our first person concept is firmly anti-Cartesian and anti-Idealist. As a consequence, it is maintained that not only is there no need to hold the Cartesian and the Idealist metaphysics of the self in order to explain why some I-judgements can be immune to error through misidentification, but it is also argued that one can no longer be either Cartesian or Idealist. For that would expose one to conceptual incoherence. (shrink)

In his contribution to Cheryl Misak's New Pragmatists volume, David Bakhurst considers the "prospect of a fruitful alliance between [ethical] particularism and pragmatism." 1 In an attempt to show that members of the two camps can "profit from critical engagement with each other's works" (124), he considers how pragmatists might help resolve three outstanding problems for ethical particularists. Unfortunately, his generosity outpaces his imagination, and he does not really find a great deal that pragmatists can contribute. So Bakhurst's potential alliance (...) ends up being a case of convergent evolution. He finds that he and his fellow particularists now occupy positions—positions against, among other .. (shrink)