Adaptive immunity provides the unique ability to respond to a nearly infinite range of antigenic determinants. Given the inherent plasticity of the adaptive immune system, a series of tolerance mechanisms exist to reduce reactivity toward self. While this reduces the probability of autoimmunity, it also creates an important gap in adaptive immunity: the ability to recognize microbes that look like self. As a variety of microbes decorate themselves in self‐like carbohydrate antigens and tolerance reduces the ability of adaptive immunity to (...) react with self‐like structures, protection against molecular mimicry likely resides within the innate arm of immunity. In this review, we will explore the potential consequences of microbial molecular mimicry, including factors within innate immunity that appear to specifically target microbes expressing self‐like antigens, and therefore provide protection against molecular mimicry. (shrink)

Methods in comparative work -- The sense of justice in Rawls -- The sense of justice in the analects -- Two senses of justice -- The contemporary relevance of a sense of justice.

Written by a diverse range of scholars, this accessible introductory volume asks: What is implicit bias? How does implicit bias compromise our knowledge of others and social reality? How does implicit bias affect us, as individuals and participants in larger social and political institutions, and what can we do to combat biases? An interdisciplinary enterprise, the volume brings together the philosophical perspective of the humanities with the perspective of the social sciences to develop rich lines of inquiry. Its 12 chapters (...) are written in a non-technical style, using relatable examples that help readers understand what implicit bias is, its significance, and the controversies surrounding it. Each chapter includes discussion questions and additional annotated reading suggestions. And a companion webpage contains teaching resources. The volume is invaluable resource for students―and researchers―seeking to understand criticisms surrounding implicit bias, as well as how one might answer them by adopting a more nuanced understanding of bias and its role in maintaining social injustice. (shrink)

Written by a diverse range of scholars, this accessible introductory volume asks: What is implicit bias? How does implicit bias compromise our knowledge of others and social reality? How does implicit bias affect us, as individuals and participants in larger social and political institutions, and what can we do to combat biases? An interdisciplinary enterprise, the volume brings together the philosophical perspective of the humanities with the perspective of the social sciences to develop rich lines of inquiry. It is written (...) in a non-technical style, using relatable examples that help readers understand what implicit bias is, its significance, and the controversies surrounding it. Each chapter includes discussion questions and additional reading suggestions. A companion webpage contains teaching resources. The volume will be an invaluable resource for students—and researchers—seeking to understand criticisms surrounding implicit bias, as well as how one might answer them by adopting a more nuanced understanding of bias and its role in maintaining social injustice. (shrink)

If you care about securing knowledge, what is wrong with being biased? Often it is said that we are less accurate and reliable knowers due to implicit biases. Likewise, many people think that biases reflect inaccurate claims about groups, are based on limited experience, and are insensitive to evidence. Chapter 3 investigates objections such as these with the help of two popular metaphors: bias as fog and bias as shortcut. Guiding readers through these metaphors, I argue that they clarify the (...) range of knowledge-related objections to implicit bias. They also suggest that there will be no unifying problem with bias from the perspective of knowledge. That is, they tell us that implicit biases can be wrong in different ways for different reasons. Finally, and perhaps most importantly, the metaphors reveal a deep—though perhaps not intractable—disagreement among theorists about whether implicit biases can be good in some cases when it comes to knowledge. (shrink)

Encourages Christian teenage girls to explore and discover Truth.

This collection brings together a diverse range of interpretivist perspectives to find fresh takes on the meanings of religion. Cutting across paradigms and traditions, experts from the UK, US, and India apply different approaches to engagement with beliefs and themes, including identity, ritual, and emotion.

Ulrich Meyer defends a novel theory about the nature of time, and argues against the consensus view that time and space are fundamentally alike. He presents the first comprehensive defense of a 'modal' account, which emphasizes the similarities between times and possible worlds in modal logic, and is easily reconciled with the theory of relativity.

A collection of essays examining the writings of William James. Provides a reinterpretation of pragmatism to devise philosophical resources for pragmatist feminism that challenge sexism and male privilege"--Provided by publisher.

Erin Plunkett draws from both analytic and continental sources to argue for the philosophical relevance of style, making the case that the essay form is uniquely suited to address the sceptical problem. The authors examined here-Montaigne, Hume, the early German Romantics, Kierkegaard and Stanley Cavell-bring into relief the relationship between scepticism and ordinary life and situate the will to know within a broader frame of meaningful human activity. The formal features of the essay call attention to time, subjectivity, and (...) language as the existential conditions of knowledge. -/- In contrast to foundationalist approaches, which expect philosophy to reach empirical or rational certainty, Plunkett demonstrates through these writings the philosophical advantages of a fragmentary, non-dogmatic style of writing. A Philosophy of the Essay shows how this medium can help us come to terms with the contingency and uncertainty of life. (shrink)

A philosopher and mother mines classic Daoist texts of Chinese philosophy for wisdom relevant to today's parents. The ancient Chinese philosopher Mencius compared children to tender sprouts, shaped by soil, sunlight, water, and, importantly, the efforts of patient farmers and gardeners. At times children require our protection, other times we need to take a step back and allow them to grow. Like sprouts, a child's character, tendencies, virtues, and vices are at once observable and ever-changing. A practical parenting manual, philosophical (...) reflection on the relationship between parent and child, and necessary response to modern stereotypes of Chinese parenting, Little Sprouts reconsiders cultural definitions of success and explores how we might support and nourish young people. Engaging deeply with foundational Daoist and Confucian thinkers, Georgetown philosopher Erin Cline offers accessible, provocative musings on key parenting issues-from family rituals to learning and vocation to challenges and disabilities-and helps us grow into better parents of joyful, fulfilled children. (shrink)

This book provides a unique, cogent, engaging account of environmental determinism that has long been much needed in the classroom and beyond." -- Andrew Sluyter, Associate Professor, Louisiana State University, USA This book pulls together major critiques of contemporary attempts to explain nature-society relations in an environmentally deterministic way. After defining key terms, it reviews the history of environmental determinism's rise and fall within geography in the early twentieth century. It discusses the key reasons for the doctrine's rejection and presents (...) alternative, non-deterministic frameworks developed within geography for analyzing the roles played by the environment in human affairs. The authors examine the rise in recent decades of neo-deterministic approaches to such issues as the demarcation of regions, the causes of civilizational collapse in prehistory, today's globally uneven patterns of human well-being, and the consequences of human-induced climate change. In each case, the authors draw on the insights and approaches of geography, the academic discipline most conversant with the interactions of society and environment, to challenge the widespread acceptance that such approaches have won. The book will appeal to those working on human-environmental research, international development and global policy initiatives. William B. Meyer is Associate Professor of Geography at Colgate University, USA. He is the author of several previous books, including Human Impact on the Earth, Americans and Their Weather: A History, and The Progressive Environmental Prometheans. His research interests include urban geography, environmental history, and the history of environmental thought. Dylan M.T. Guss works in the technology investment sector. (shrink)

This chapter examines the views of seventeenth-century British philosophers on the relation between virtue and hedonism, explaining that many philosophers believed that a defense of virtue required rejection of hedonism. It discusses the reformulation of moral philosophy proposed by Thomas Hobbes, and analyzes the reactions of Richard Cumberland and Cambridge Platonists Ralph Cudworth and Henry More. The chapter also considers the revival of Epicureanism and early modern natural law theory.

Gerechtigkeit findet nicht nur zwischen Zeitgenossen statt - auch das Handeln früher lebender Menschen kann Ansprüche und Pflichten gegenwärtig und zukünftig lebender Menschen begründen. Der Autor entwickelt die Theorie einer historischen Gerechtigkeit auf der Basis der Pflichten zwischen den Generationen. Pluspunkte: Darstellung eines zentralen Themas aktueller politischer, ethischer und gesellschaftlicher Debatten Diskussionsgrundlage für Philosophen, Politikwissenschftler sowie interessierte Laien zeigt praktizierbare Lösungsansätze auf.

Este ensayo busca trazar una genealogía defectuosa de varias escenas de lectura en la obra de Jacques Lezra. Se enfoca en la lectura como práctica metodológica salvaje que conjuga —de manera inesperada, contraintuitiva, e indisciplinada— objetos, discursos, y modalidades conceptuales. Se analiza una selección de escenas de lectura de Materialismo salvaje y República salvaje para identificar en ellas un pensamiento estético-político que imagina corrientes subterráneas y deconstruye conceptos como soberanía, institución, y normatividad, enfatizando su carácter defectuoso.

Much has been made of the importance of training ethical, socially conscious engineers, but does US engineering education actually encourage neophytes to take seriously their professional responsibility to public welfare? Counter to such ideals of engagement, I argue that students’ interest in public welfare concerns may actually decline over the course of their engineering education. Using unique longitudinal survey data of students at four colleges, this article examines (a) how students’ public welfare beliefs change during their engineering education, (b) whether (...) engineering programs emphasize engagement, and (c) whether these program emphases are related to students’ public welfare beliefs. I track four specific public welfare considerations: the importance to students of professional/ethical responsibilities, understanding the consequences of technology, understanding how people use machines, and social consciousness. Suggesting a culture of disengagement, I find that the cultural emphases of students’ engineering programs are directly related to their public welfare commitments and students’ public welfare concerns decline significantly over the course of their engineering education. However, these findings also suggest that if engineering programs can dismantle the ideological pillars of disengagement in their local climates, they may foster more engaged engineers. (shrink)

The computations involved in statistical learning have long been debated. Here, we build on work suggesting that a basic memory process, chunking, may account for the processing of statistical regularities into larger units. Drawing on methods from the memory literature, we developed a novel paradigm to test statistical learning by leveraging a robust phenomenon observed in serial recall tasks: that short‐term memory is fundamentally shaped by long‐term distributional learning. In the statistically induced chunking recall (SICR) task, participants are exposed to (...) an artificial language, using a standard statistical learning exposure phase. Afterward, they recall strings of syllables that either follow the statistics of the artificial language or comprise the same syllables presented in a random order. We hypothesized that if individuals had chunked the artificial language into word‐like units, then the statistically structured items would be more accurately recalled relative to the random controls. Our results demonstrate that SICR effectively captures learning in both the auditory and visual modalities, with participants displaying significantly improved recall of the statistically structured items, and even recall specific trigram chunks from the input. SICR also exhibits greater test–retest reliability in the auditory modality and sensitivity to individual differences in both modalities than the standard two‐alternative forced‐choice task. These results thereby provide key empirical support to the chunking account of statistical learning and contribute a valuable new tool to the literature. (shrink)

If someone says, “Asians are good at math” or “women are empathetic,” I might interject, “you're stereotyping” in order to convey my disapproval of their utterance. But why is stereotyping wrong? Before we can answer this question, we must better understand what stereotypes are and what stereotyping is. In this essay, I develop what I call the descriptive view of stereotypes and stereotyping. This view is assumed in much of the psychological and philosophical literature on implicit bias and stereotyping, yet (...) it has not been sufficiently defended. The main objection to the descriptive view is that it fails to include the common-sense idea that stereotyping is always objectionable. I argue that this is actually a benefit of the view. In the essay's final part, I put forward two hypotheses that would validate the claim that stereotyping is always morally or epistemically wrong. If these hypotheses are false—which is very likely—we have little reason to build moral or epistemic defect into the very idea of a stereotype. Moreover, we must abandon the seemingly attractive claim that judging individuals based on group membership is intrinsically wrong. (shrink)

In visually cataloging the endearing and enigmatic ways in which the built environment takes shape, 'Best Practices' proposes a new way of thinking about neighbourhoods, housing developments, streetscapes, and storefronts, not so much as places defined by building codes, dimensions, or geographic features, but as assemblages of ad hoc interventions and incidental ephemera. Drawing on the history of architecture, media theory, cultural anthropology, and urban studies, 'Best Practices' pairs photographic documentation with extensive captions and citations to define a territory within (...) the margins between the sanctioned and unsanctioned, the regulated and unregulated, the tasteful and tacky, the novel and the nonsense. While not necessarily in opposition of those mechanisms, Best Practices asserts that interest, knowledge, and meaning are more often generated on the lines that divide such categories. This book advocates for a more thorough consideration of the unauthorised remodels, slap-dash handiwork, haphazard paint jobs, half-hearted do-it-yourself projects, cracked facades, contradictions, compromises, and coincidences. (shrink)

How does our conception of possibility contribute to our understanding of self and world? In what sense does the possible differ from the merely probable, and what would it mean to treat possibility as part of the real? This book is an opportunity to see Kierkegaard as contributing to a distinctive phenomenology, ontology, and psychology of possibility that addresses the question of our existential relationship to the possible. The term 'possibility' (Mulighed) and its variants occur with curious frequency across Kierkegaard's (...) writings. Key to Kierkegaard's understanding of the self, possibility is linked to a number of core concepts in his works: from imagination, anxiety, despair, and 'the moment' to the idea in The Sickness Unto Death that “God is that all things are possible”. Responding to what he sees as a Hegelian and Aristotelian misunderstanding of possibility, Kierkegaard offers a novel reading of the possible that, in turn, directly influences 20th-century philosophers such as Heidegger, Deleuze, and Derrida. Kierkegaard gives a rich account of how anxiety and despair, as lived experiences of possibility, not only show us the contingency and fragility of the systems and identities we presently inhabit but also reveal a more fundamental contingency that demands a new way of relating to the possible. For Kierkegaard, hope, faith, and love are attitudes in which meaning is forged by embracing contingency. In a time of political, social, and environmental uncertainty Kierkegaard's work on radical possibility seems more relevant than ever. (shrink)

If someone says, “You’ve stereotyped me,” we hear the statement as an accusation. One way to interpret the accusation is as follows: you haven’t seen or treated me as an individual. In this essay, I interpret and evaluate a theory of wrongful stereotyping inspired by this thought, which I call the failure-to-individualize theory of wrongful stereotyping. According to this theory, stereotyping is wrong if and only if it involves failing to treat persons as individuals. I argue that the theory—however one (...) interprets it—is inadequate. Either the theory will not reliably identify all cases of wrongful stereotyping or it will fail to adequately explain why they are wrong. I conclude that it does not follow that we must entirely jettison the objection that stereotyping fails to treat persons as individuals. What follows is only that the objection must play a more circumscribed role in a theory of when and why stereotyping is wrong. (shrink)

Cognitive Science, Volume 46, Issue 9, September 2022.

Empirical science, such as psychology and neuroscience, employ diverse methods to develop data driven models and explanations for complex phenomena. In research on the self, differences in these methods produce different depictions of persons. Research in developmental psychology highlights the role of intuitive beliefs, such as psychological essentialism and intuitive dualism, in individuals’ singular, cohesive, and stable sense of self. On the other hand, research in neuroscience highlights the de-centralized, distributed, multitudes of neural networks in competition making selves, with arguments (...) around whether the interpretation of these data imply that the self is somehow fundamental and special to human functioning. In this paper, I explore these discrepant pictures of the self to advance understanding about personhood. Specifically, I suggest that these divergent pictures of self from psychology and neuroscience have the potential to inform philosophical and theological discussions around personhood by anchoring models of persons in empirical views of persons. Likewise, I explore the opportunity for philosophy and theology to inform and enhance scientific research on the self by critiquing scientific bias and construct development as well as highlighting potential limits in understanding selves with empirical models. (shrink)

Local food systems can have economic and social benefits by providing income for producers and improving community connections. Ongoing global climate change and the acute COVID-19 pandemic crisis have shown the importance of building equity and resilience in local food systems. We interviewed ten stakeholders from organizations and institutions in a U.S. midwestern city exploring views on past, current, and future conditions to address the following two objectives: 1) Assess how local food system equity and resilience were impacted by the (...) COVID-19 pandemic, and 2) Examine how policy and behavior changes could support greater equity and resilience within urban local food systems. We used the Community Capitals Framework to organize interviewees’ responses for qualitative analyses of equity and resilience. Four types of community capital were emphasized by stakeholders: cultural and social, natural, and political capital. Participants stated that the local food system in this city is small; more weaknesses in food access, land access, and governance were described than were strengths in both pre- and post-pandemic conditions. Stakeholder responses also reflected lack of equity and resilience in the local food system, which was most pronounced for cultural and social, natural and political capitals. However, local producers’ resilience during the pandemic, which we categorized as human capital, was a notable strength. An improved future food system could incorporate changes in infrastructure (e.g., food processing), markets (e.g., values-based markets) and cultural values (e.g., valuing local food through connections between local producers and consumers). These insights could inform policy and enhance community initiatives and behavior changes to build more equitable and resilient local food systems in urban areas throughout the U.S. Midwest. (shrink)

How linguistic structures evolve so as to become easier to process is addressed by Isbilen and Christiansen for the Now‐or‐Never bottleneck. The authors suggest that this fundamental challenge in language processing is coped with by rapid compression of the transient linguistic input into chunks then to be passed on. As linguistic structures that can be chunked more easily tend to stabilize and proliferate, language evolves to fit learners’ cognitive capabilities.

Y a-t-il une seule et unique morale dont on puisse se prévaloir aujourd'hui? Les réflexions philosophiques sur la morale se sont toujours combattues, remplacées, démenties au fil du temps, tout en étant chacune valable. Le stoïcisme, la morale de la vertu, le recours à la loi morale, l'utilitarisme sont autant de courants qui irriguent encore notre façon de penser. Mais laquelle de ces "visions" choisir? Et pourquoi choisir celle-là plutôt qu'une autre? Michel Meyer opère ici un retournement de la (...) pensée traditionnelle sur l'éthique. C'est parce que l'homme est un problème pour l'homme qu'il y a des réponses qu'on appelle la morale. Michel Meyer ne part plus des sujets éthiques (Moi, l'Autre) comme référents moraux, mais de la distance, plus ou moins grande, entre les individus. C'est la variation de cette distance qui influence nos choix quant au bien et au mal, à ce que l'on recherche ou à ce que l'on veut fuir ou éviter, et qui fera qu'on sera tantôt stoïcien, tantôt utilitariste ou kantien. Le positionnement des sujets les uns par rapport aux autres conduit à agir de telle ou telle manière, donc à adopter tel ou tel type de conduite morale et à juger ce qui est bien ou mal de façon différente. Le problème moral, c'est l'Autre comme problème, auquel il convient de répondre selon la distance qui nous sépare, nous divise ou nous rapproche, et auquel on répond toujours d'ailleurs, parce qu'il constitue une menace, un appel à l'aide, ou encore la nécessité de coopérer. Sans chercher à édicter de nouvelles règles ou de nouveaux préceptes, Michel Meyer replace les grandes théories morales, comme celles d'Aristote, de Kant, de Mill ou encore de Hume, dans un espace philosophique virtuel qui est leur espace de validité. Avec le concept de distance entre les êtres, il nous offre ainsi une approche nouvelle et synthétique de la morale. (shrink)

This article offers a straightforward reading of Hume's ‘narrow circle’ – the boundary employed to define those with whom we sympathize in assessing an agent's moral character – that follows from a more careful look at his account of virtue. Hume employs a principle that can be understood as a virtue ethical equivalent of associative obligation, which thereby delimits the boundaries of this circle. This reading avoids concerns about unjustified partiality, moral blind spots, and demandingness, and shows a clear path (...) for reaching uniform moral judgments; it also offers a new perspective on virtue of interest for contemporary virtue ethics. (shrink)

Can one coherently integrate Darwin's view of evolution with an affirmation of the value of existence? In this fresh, lean, and substantive volume, William Meyer addresses this important question. By carefully analyzing Darwin's own writings and by drawing on the philosophical perspectives of William James, Alfred North Whitehead, and others, Meyer persuasively redirects the cultural conversation about Darwin away from the retrospective question of origins toward the prospective question concerning the ultimate significance of evolutionary life. As James recognized, (...) the question about the reality of God is more critical for the forward-looking question of value than it is for the backward-looking question of origins. Darwin was a theist in search of a better theism, and because theology had not yet caught up to him, he became increasingly agnostic and caught between his mechanistic understanding of nature, on the one hand, and his affirmation of the value and beauty of the world, on the other. Whitehead's philosophy of organism offers a way to integrate Darwin's evolutionary insights with his affirmation of the grandeur of nature. Meyer's clearly written and richly argued book enables us to integrate our evolutionary understanding of the world with our experience of value within it. (shrink)

Rawls's signature is the thought experiment he introduced to sort out the requirements of justice. Rawls argues that “justice as fairness” will be a form of political liberalism. Rawls claims that under free institutions we should expect “profound and irreconcilable differences” in people's religious and philosophical worldviews, and in people's basic notions of what makes life worth living. In his vision of democracy, the solidarity required to support common political values and egalitarian norms of distributive justice must be built through (...) productive and fair social cooperation. Social solidarity is needed to support democratic equality, and this solidarity must be built through the mutual production and reciprocal sharing of the fruits of social cooperation. Constraining socioeconomic inequality is an essential aspect of a just scheme of social cooperation and a necessary basis for securing a mutual commitment to the rights, liberties, and opportunities that give democracy its substance and meaning. (shrink)

While there has been extensive research on deception, extant literature has not examined how deception is processed solely from the customer's perspective. Extensive qualitative interviews were conducted and analyzed to inform the proposed framework. Cognitive dissonance theory and attribution theory are used to frame the process consumers go through when deception is perceived. When consumers perceive deceit, they will consider attribution before determining intentionality. Internal attributions relieve the company of wrongdoing to some extent, whereas external attributions lead consumers to examine (...) several elements of deception including intent. Unintentional deceit will trigger assessments of magnitude, stability, and switching costs; while less is considered when deceit is intentional. The findings of this research are important for advancing theory in relation to deceit and for helping practitioners understand the importance of changing consumer cognitions before consumers decide to change their behavior by discontinuing the relationship. (shrink)

While people’s lives continue to be put at risk by the dearth of organs available for transplantation, we must give urgent consideration to any option that may make up the shortfall. A market in organs from living donors is one such option. The market should be ethically supportable, and have built into it, for example, safeguards against wrongful exploitation. This can be accomplished by establishing a single purchaser system within a confined marketplace.Statistics can be dehumanising. The following numbers, however, have (...) more impact than most: as of 24th November, during 2002 in the United Kingdom, 667 people have donated organs, 2055 people have received transplants, and 5615 people are still awaiting transplants.1 It is difficult to estimate how many people die prematurely for want of donor organs. “In the world as a whole there are an estimated 700 000 patients on dialysis . . . . In India alone 100 000 new patients present with kidney failure each year”2 . Almost “three million Americans suffer from congestive heart failure . . . deaths related to this condition are estimated at 250 000 each year . . . …. (shrink)

In this wide-ranging and probing book Erin Manning extends her previous inquiries into the politics of movement to the concept of the minor gesture. The minor gesture, although it may pass almost unperceived, transforms the field of relations. More than a chance variation, less than a volition, it requires rethinking common assumptions about human agency and political action. To embrace the minor gesture's power to fashion relations, its capacity to open new modes of experience and manners of expression, is (...) to challenge the ways in which the neurotypical image of the human devalues alternative ways of being moved by and moving through the world—in particular what Manning terms "autistic perception." Drawing on Deleuze and Guattari's schizoanalysis and Whitehead's speculative pragmatism, Manning's far-reaching analyses range from fashion to depression to the writings of autistics, in each case affirming the neurodiversity of the minor and the alternative politics it gestures toward. (shrink)

What role does traditional ecological knowledge play in the lives of smallholder farmers in post-conflict communities as they cope with the destructive impacts of war? In many cases, military weapons, such as unexploded bombs, are left behind in the surrounding landscape, forcing farmers to adapt their livelihood practices to the increased risk of death and injury. We analyze trends in the local production of knowledge in Ratanak Kiri province, Cambodia, an area heavily bombarded by the US Air Force during the (...) Vietnam War. We argue that the system of traditional ecological knowledge has adapted to include basic information on bomb identification, location, and management strategies. This factual approach gives individuals the flexibility to generate their own views on whether they perceive unexploded ordnance as a violent hazard and/or an economic commodity. In a relatively short 50-year time period, the body of knowledge has been quickly accumulated and culturally transmitted to family and neighbors. Our findings suggest that traditional ecological knowledge should not be reduced to a static and ancient form of collective memory. We call for the expansion of the concept of traditional ecological knowledge to include short-term and dynamic processes of knowledge generation. (shrink)