Person, reason, and value -- Moral value, intentionality, and community -- Suicide and the right to die -- Abortion, personhood, and community -- Euthanasia : a reinterpretation -- The death penalty and purposes of punishment -- Privacy, private property, and justice -- The personalist society, community, and justice -- The moral treatment of animals -- Affirmative action and justice -- Community and the environmental crisis.

Large-scale whole genome sequencing (WGS) studies promise to revolutionize cancer research by identifying targets for therapy and by discovering molecular biomarkers to aid early diagnosis, to better determine prognosis and to improve treatment response prediction. Such projects raise a number of ethical, legal, and social (ELS) issues that should be considered. In this study, we set out to discover how these issues are being handled across different jurisdictions.

Background Outbreaks of infectious disease cause serious and costly health and social problems. Two new technologies – pathogen whole genome sequencing and Big Data analytics – promise to improve our capacity to detect and control outbreaks earlier, saving lives and resources. However, routinely using these technologies to capture more detailed and specific personal information could be perceived as intrusive and a threat to privacy. Method Four community juries were convened in two demographically different Sydney municipalities and two regional cities in (...) New South Wales, Australia to elicit the views of well-informed community members on the acceptability and legitimacy of: making pathogen WGS and linked administrative data available for public health researchusing this information in concert with data linkage and machine learning to enhance communicable disease surveillance systems Fifty participants of diverse backgrounds, mixed genders and ages were recruited by random-digit-dialling and topic-blinded social-media advertising. Each jury was presented with balanced factual evidence supporting different expert perspectives on the potential benefits and costs of technologically enhanced public health research and communicable disease surveillance and given the opportunity to question experts. Results Almost all jurors supported data linkage and WGS on routinely collected patient isolates for the purposes of public health research, provided standard de-identification practices were applied. However, allowing this information to be operationalised as a syndromic surveillance system was highly contentious with three juries voting in favour, and one against by narrow margins. For those in favour, support depended on several conditions related to system oversight and security being met. Those against were concerned about loss of privacy and did not trust Australian governments to run secure and effective systems. Conclusions Participants across all four events strongly supported the introduction of data linkage and pathogenomics to public health research under current research governance structures. Combining pathogen WGS with event-based data surveillance systems, however, is likely to be controversial because of a lack of public trust, even when the potential public health benefits are clear. Any suggestion of private sector involvement or commercialisation of WGS or surveillance data was unanimously rejected. (shrink)

This study explores gratitude as a multidimensional and work-specific construct. Utilizing a sample of 625 employees from a variety of positions in a medium-sized school district in the United States, we developed and evaluated a new measure, namely the Work Gratitude Scale, which encompasses recognized conative, cognitive, affective, and social aspects of gratitude. A systematic, six-phased approach through structural equation modeling was used to explore and confirm the factorial structure, internal consistency, measurement invariance, concurrent, convergent, and discriminant validity of the (...) WGS. The results supported a 10-item measure with three dimensions: “grateful appraisals”, “gratitude toward others”, and “intentional attitude of gratitude”. Thereafter, first-order, second-order, and bifactor confirmatory models were estimated and compared. Work gratitude was found to be best described by a second-order construct with three underlying first-order dimensions. Measurement invariance was supported in relation to gender. Concurrent validity was supported in relation to two existing dispositional gratitude scales, namely the Gratitude Questionnaire and the Gratitude, Resentment, and Appreciation Scale. Convergent validity was supported in relation to the Core Self-Evaluations Scale and the Psychological Capital Questionnaire. Discriminant validity was supported in relation to various demographic factors such as age, gender, occupation, and tenure. The findings support the WGS as a multidimensional measure that can be used in practice to measure overall work-related gratitude and to track the effectiveness of gratitude-related workplace interventions. (shrink)

Whole genome and exome sequencing techniques raise hope for a new scale of diagnosis, prevention, and prediction of genetic conditions, and improved care for children. For these hopes to materialize, extensive genomic research with children will be needed. However, the use of WGS/WES in pediatric research settings raises considerable challenges for families, researchers, and policy development. In particular, the possibility that these techniques will generate genetic findings unrelated to the primary goal of sequencing has stirred intense debate about whether, which, (...) how, and when these secondary or incidental findings should be returned to parents and minors. The debate is even more pronounced when the subjects are adolescents, for whom decisions about return of SFs may have particular implications. In this paper, we consider the rise of “genomic citizenship” and the main challenges that arise for these stakeholders: adolescents' involvement in decisions relating to return of genomic SFs, the types of SFs that should be offered, privacy protections, and communication between researchers and adolescents about SFs. We argue that adolescents' involvement in genomic SF-related decisions acknowledges their status as valuable stakeholders without detracting from broader familial interests, and promotes more informed genomic citizens. (shrink)

Expressiveness and decidability are two core aspects of programming languages that should be thoroughly known by those who use them; this includes knowledge of their metalanguages a.k.a. formal grammars. The van Wijngaarden grammars (WGs) are capable of generating all the languages in the Chomsky hierarchy and beyond; this makes them a relevant tool in the design of (more) expressive programming languages. But this expressiveness comes at a very high cost: The syntax of WGs is extremely complex and the decision problem (...) for the generated languages is generally unsolvable. With this in mind, I provide here a short primer of the syntax of WGs, which includes syntactic restrictions that guarantee decidability for the corresponding generated languages. (shrink)

Whether, and to what degree, do patents granted on human genes cast a shadow of uncertainty over genomics and its applications? Will owners of patents on individual genes or clusters of genes sue those performing whole-genome analyses on human samples for patent infringement? These are related questions that have haunted molecular diagnostics companies and services, coloring scientific, clinical, and business decisions. Can the profusion of whole-genome analysis methods proceed without fear of patent infringement liability?Whole-genome sequencing is proceeding apace. Academic centers (...) have been performing whole-genome and -exome sequencing in research for at least five years, and academic clinical laboratories with national reach have been doing sequencing for clinical applications for almost as long. Companies have also been offering WGS and WES as a clinical service for a few years now. So far as we know, no one has been sued for infringement of “gene patents” for performing WGS. (shrink)

The objective of Working Group 4 of the COST Action NET4Age-Friendly is to examine existing policies, advocacy, and funding opportunities and to build up relations with policy makers and funding organisations. Also, to synthesize and improve existing knowledge and models to develop from effective business and evaluation models, as well as to guarantee quality and education, proper dissemination and ensure the future of the Action. The Working Group further aims to enable capacity building to improve interdisciplinary participation, to promote knowledge (...) exchange and to foster a cross-European interdisciplinary research capacity, to improve cooperation and co-creation with cross-sectors stakeholders and to introduce and educate students SHAFE implementation and sustainability. To enable the achievement of the objectives of Working Group 4, the Leader of the Working Group, the Chair and Vice-Chair, in close cooperation with the Science Communication Coordinator, developed a template to map the current state of SHAFE policies, funding opportunities and networking in the COST member countries of the Action. On invitation, the Working Group lead received contributions from 37 countries, in a total of 85 Action members. The contributions provide an overview of the diversity of SHAFE policies and opportunities in Europe and beyond. These were not edited or revised and are a result of the main areas of expertise and knowledge of the contributors; thus, gaps in areas or content are possible and these shall be further explored in the following works and reports of this WG. But this preliminary mapping is of huge importance to proceed with the WG activities. In the following chapters, an introduction on the need of SHAFE policies is presented, followed by a summary of the main approaches to be pursued for the next period of work. The deliverable finishes with the opportunities of capacity building, networking and funding that will be relevant to undertake within the frame of Working Group 4 and the total COST Action. The total of country contributions is presented in the annex of this deliverable. (shrink)

"Nietzsche is infuriatingly difficult to comprehend as he sets to tearing down every scaffold left from the old world. Beyond Good and Evil represents Nietzsche in his maturity, being written later in life. It is also some of his clearest writing since it is intentionally polemical. None of his writing is known particularly for its moderation, but Beyond Good and Evil is written as an assault on half-hearted philosophers who are still playing about with the old world. But he is (...) a particularly infuriating read for those who see the world as made and ruled by God. He is difficult to understand since he seeks to remove everything that makes such a world comprehensible. But to say this is simply to describe our age, and for this reason Nietzsche is valuable. But be warned, he will not be trifled with. Sit with him and listen as he seeks to remove every vestige of God from the world." The Worldview Guides from the Canon Classics Literature Series provide an aesthetic and thematic Christian perspective on the most definitive and daunting works of Western Literature. Each Worldview Guide presents the big picture (both the good and the bad) without neglecting the details. Each Worldview Guide is a friendly literary coach--and a treasure map, and a compass, and a key--to help teachers, parents, and students appreciate, critique, and begin to master the classics. The bite-size WGs are divided into these ten sections (with some variation due to genre): Introduction, The World Around, About the Author, What Other Notables Said, Structure and Audience, Worldview Analysis, Quotables, 21 Significant Questions & Answers, and Further Discussion & Review. (shrink)

W artykule autor analizuje teorię autorytetu przedstawioną przez Trinkaus Zagzebski. Teoria ta podkreśla rolę zaufania w uzasadnianiu zdań, m.in. wskazując na ograniczenia stanowiska egoizmu poznawczego, dla którego ideałem jest sytuacja, w której podmiot, uzasadniając swe przekonania, polega tylko na własnych zdolnościach poznawczych. Trinkaus Zagzebski broni uniwersalizmu poznawczego, wg którego już sam fakt, że osoba x, głosi że p, jest prima facie racją za p. W tekście autor wskazuje na słabe punkty uniwersalizmu i konkluduje, że albo uznamy to stanowisko z jego (...) konsekwentnym odrzuceniem tezy o równości podmiotów poznających, albo też mimo wszystko opowiemy się za egoizmem poznawczym. Autor uznaje przy tym, że amerykańska filozofka daje nam wskazówki, jak ulepszyć owo stanowisko, by nie prowadziło ono do twierdzeń sprzecznych z intuicją. (shrink)

Currently, there are no computerized tools enabling objective interpretation of observational gait assessment based on Wisconsin Gait Scale, which is a reliable and well-tested tool. The solution envisaged by us may provide a practical tool for assessing gait deviations in patients with hemiparesis after stroke. The present study assessed agreement between a new application software for computerized WGS and 3-dimensional gait analysis, and reliability of the application. The study involved 33 individuals with hemiparesis after stroke. The software was developed based (...) on a model designed taking into account components of the WGS and incorporating auxiliary lines passing through the relevant anthropometric points on the patient’s body, as well as measurements of angular values, distances and duration of the specific gait phases, which make it possible to substantiate assessment based on this scale. Series of videos were made to record gait of the qualified patients. After the gait evaluation was carried out using the app, the data were retrieved from the software. The gait assessment was performed separately by three independent examiners who reviewed the video recording using the new app twice. Additionally, 3DGA was carried out for all the subjects, and the results of the app-aided assessment were compared to those acquired using 3DGA. The findings show statistically significant correlations between majority of the WGS items measured using the new app, and the relevant spatiotemporal and kinematic parameters identified by 3DGA. Agreement between the scores reported by the three examiners was high in both measurements, as reflected by Cronbach’s alpha exceeding 0.8. The findings reflect very good intra-observer reliability and inter-observer reliability of the new application software for computerized WGS. The opportunities offered by the observational gait scale objectified through our new software for computerized WGS result from the fact that the tool provides a useful low-cost and time-effective feedback to monitor ongoing treatments or formulate hypotheses. (shrink)

Identification of Pygopus in Drosophila as a dedicated component of the Wg (fly homolog of mammalian Wnt) signaling cascade initiated many inquiries into the mechanism of its function. Surprisingly, the nearly exclusive role for Pygopus in Wg signal transduction in flies is not seen in mice, where Pygopus appears to have both Wnt‐related and Wnt‐independent functions. This review addresses the initial findings of Pygopus as a Wg/Wnt co‐activator in light of recent data from both fly and mammalian studies. We compare (...) and contrast the developmental phenotypes of pygopus mutants to those characterized for known Wg/Wnt transducers and explore the data regarding a role for mammalian Pygopus 2 in tumorigenesis. We further analyze the roles of the two conserved domains of Pygopus proteins in transcription, and propose a model for the molecular mechanism of Pygopus function in both Wg/Wnt signaling and Wnt‐independent transcriptional regulation. BioEssays 30:448–456, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

From Dr. Littlejohn's guide: "You'd never know Athens was locked in a life-or-death struggle from the tranquil and leisurely philosophical discussion that unfolds through the pages of the Republic...Plato's masterpiece continues to inform our questions and our thinking when it comes to being, truth, beauty, goodness, justice, community, the soul, and more." The Worldview Guides from the Canon Classics Literature Series provide an aesthetic and thematic Christian perspective on the most definitive and daunting works of Western Literature. Each Worldview Guide (...) presents the big picture (both the good and the bad) without neglecting the details. Each Worldview Guide is a friendly literary coach -- and a treasure map, and a compass, and a key -- to help teachers, parents, and students appreciate, critique, and begin to master the classics. The bite-size WGs are divided into these ten sections (with some variation due to genre): Introduction, The World Around, About the Author, What Other Notables Said, Setting, Characters, & Argument, Worldview Analysis, Quotables, 21 Significant Questions & Answers, Further Discussion & Review, and instructions for how to take the Classics Quiz. (shrink)

In this chapter I suggest how Casey’s work opens some radical implications for phenomenology. Casey does this by showing that place is what first of all grants room for the appearance of things—but only in virtue of a non givenness. That is, place undergirds determinate things only in being something “less” than fully delimited or determinate, something less than space would be as an already given dimension. Place thus echoes Bergson’s durée as openly generative becoming, in contrast to time as (...) already fixed dimension. In showing us how determinate phenomena are conditioned by place as less than given, and in complementary work on “periphenomena” (see, e.g., WG 438-448), such as glances and edges, Casey reveals what I call a subliminal dimension of phenomena: a way in which periphenomena and thence phenomena appear as delimited only by edging out into what is less than delimitable. This subliminal dimension is phenomenologically paradoxical. It cannot appear as such, precisely because it is less than delimitable, vagrant with respect to classical conditions of appearance. Yet this vagrant “less than” precisely appears as subliminal within and to delimited appearances, versus being something ideal or behind appearances. (shrink)

This article extends Lemieux’s concern for the interdisciplinary tension between philosophy and sociology to the intradisciplinary tension within psychology between approaches to the study of children focusing on universal principles and approaches adopting a contextual lens. This tension arises both in how development is defined and in the methods chosen for its study. This tension is exemplified in terms of the recent American preoccupation with the Word Gap (WG), a supposed difference of 30 million words heard by socioeconomically diverse children (...) by the age of 4 that is blamed for educational disparities throughout the school years. The article discusses the political implications of WG discourse as it gives rise to the erasure of language practices of diverse Americans and obscures the role that the educational system plays in fostering a ‘one-size-fits-all’ instructional model. The article concludes with a discussion of attempts to combat the deficit model that the WG discourse reproduces. (shrink)

Since military planners must know the size and shape of the earth if they hope to track earth-orbiting satellites and to target missiles on distant lands, geodesy was an important concern of the two superpowers during the Cold War. The most important geodetic product in the United States was a series of increasingly powerful World Geodetic Systems, the first of which was published for the Department of Defense in 1960. Although WGS 60 was created because of intense international rivalries, it (...) reflected the intense rivalries between America's Army and its Air Force, and it introduced the notion of 'political geodesy'. My attention to American events does not indicate a lack of interest in the Soviet story; rather, I hope that historians with better language skills and better access to Soviet documents will examine geodetic research on the other side of the former Iron Curtain. (shrink)

Pojęcie narzędzia językowego wydaje się być obecne w analizach języka. Jednak ani w koncepcji języka formalnego, czy aktów mowy, ani w pragmatyce pojęcie to właściwie nie występuje literalnie. W najlepszym wypadku stanowi pewien punkt odniesienia, jak w koncepcji gier językowych L. Wittgensteina. W tekście stawia się tezę, że analiza języka jako narzędzia nie jest możliwa, gdy narzędzie jest rozumiane zdroworozsądkowo, pozwala na to natomiast zmiana rozumienia narzędzia, a dokładniej jego radykalizacja. Radykalizacja ta polega na pominięciu zdroworozsądkowej intuicji, że narzędzie to (...) obiekt posiadający zewnętrznego wobec niego użytkownika. Pokazuje się, że tak właśnie rozumiane narzędzie występuje w koncepcji narzędzi do myślenia Dennetta, proponuje się także zarys interpretacji koncepcji języka wg Bickertona oraz obrazkowej teorii języka L. Wittgensteina w terminach narzędzia radykalizowanego. (shrink)

Emerging genomic technologies promise more efficient infectious disease control. Whole genome sequencing is increasingly being used in tuberculosis diagnosis, surveillance, and epidemiology. However, while the use of WGS by public health agencies may raise ethical, legal, and socio-political concerns, these challenges are poorly understood. Between November 2017 and April 2018, we conducted semi-structured interviews with 22 key stakeholders across the fields of governance and policy, public health, and laboratory sciences representing the major jurisdictions currently using WGS in national TB programs. (...) Thematic analysis of the interviews was conducted using NVivo 11. Respondents identified several ethical and practical challenges associated with WGS in TB care and surveillance, all related to issues of trust, including: 1) the power of public health; 2) data sharing and profits derived from surveillance efforts; and 3) concerns regarding who has access to, and can benefit from, the technology. Additional challenges included: the potential utility that WGS adds to a public health program, the risks associated with linking necessary epidemiological metadata to the genomic data, and challenges associated with jurisdictional capacity to implement the technology. Successful implementation of WGS is dependent on fostering relationships of trust between those working with genomics technology and those directly impacted by it, including clinicians. Building trust between the public and the public health agencies and within public health agencies themselves is critical due to the inherent complexity of WGS and its implementation for communicable disease control purposes. (shrink)