The human genome project's lasting legacies are the emerging insights into human physiology and disease, and the ascendance of biology as the dominant science of the 21st century. Sequencing revealed that >90% of the human genome is not coding for proteins, as originally thought, but rather is overwhelmingly transcribed into non‐protein coding, or non‐coding, RNAs (ncRNAs). This discovery initially led to the hypothesis that most genomic DNA is “junk”, a term still championed by some geneticists and evolutionary biologists. In contrast, (...) molecular biologists and biochemists studying the vast number of transcripts produced from most of this genome “junk” often surmise that these ncRNAs have biological significance. What gives? This essay contrasts the two opposing, extant viewpoints, aiming to explain their bases, which arise from distinct reference frames of the underlying scientific disciplines. Finally, it aims to reconcile these divergent mindsets in hopes of stimulating synergy between scientific fields. (shrink)

Views from one of the most original cultural critics of the twentieth century, Walter Benjamin.

Benenson et al. provide a compelling case for treating greater investment into self-protection among females as an adaptive strategy. Here, we wish to expand their proposed adaptive explanation by placing it squarely in modern state-based and behavioural life-history theory, drawing on Veit'spathological complexityframework. This allows us to make sense of alternative “lifestyle” strategies, rather than pathologizing them.

"Local History/Global Designs" is one of the most important books in the historical humanities to have emerged since the end of the Cold War University. This is vintage Mignolo: packed with insights, breadth, and intellectual zeal.

Argument for the role of the human conscience in determining right and wrong, good and evil.

Walter applies the methodology of neurophilosophy to one of philosophy's centralchallenges, the notion of free will. Neurophilosophical conclusions are based on, and consistentwith, scientific knowledge about the brain and its functioning.

A translation of the main text for only published version J. G. Fichte's later WL. (Hitzig: Berlin 1810). It excludes Fichte's Preface.

Starting from the study of the physical world, we develop the concept of a dual pair, Comparing dual pairs is known as duality. We show that duality is a basic mechanism for our intellectual curiosity.

Renaissance logician, philosopher, humanist, and teacher, Peter Ramus (1515-72) is best known for his attack on Aristotelian logic, his radical pedagogical theories, and his new interpretation for the canon of rhetoric. His work, published in Latin and translated into many languages, has influenced the study of Renaissance literature, rhetoric, education, logic, and--more recently--media studies. Considered the most important work of Walter Ong's career, Ramus, Method, and the Decay of Dialogue is an elegant review of the history of Ramist scholarship (...) and Ramus's quarrels with Aristotle. A key influence on Marshall McLuhan, with whom Ong enjoys the status of honorary guru among technophiles, this challenging study remains the most detailed account of Ramus's method ever published. Out of print for more than a decade, this book--with a new foreword by Adrian Johns--is a canonical text for enthusiasts of media, Renaissance literature, and intellectual history. (shrink)

This book examines John Locke's claims about the nature and workings of language. Walter Ott proposes an interpretation of Locke's thesis in which words signify ideas in the mind of the speaker, and argues that rather than employing such notions as sense or reference, Locke relies on an ancient tradition that understands signification as reliable indication. He then uses this interpretation to explain crucial areas of Locke's metaphysics and epistemology, including essence, abstraction, knowledge and mental representation. His discussion challenges (...) many of the orthodox readings of Locke, and will be of interest to historians of philosophy and philosophers of language alike. (shrink)

Mental causation, our mind's ability to causally affect the course of the world, is part and parcel of our ‘manifest image’ of the world. That there is mental causation is denied by virtually no one. How there can be such a thing as mental causation, however, is far from obvious. In recent years, discussions about the problem of mental causation have focused on Jaegwon Kim's so-called Causal Exclusion Argument, according to which mental events are ‘screened off’ or ‘preempted’ by physical (...) events unless mental causation is a genuine case of overdetermination or mental properties are straightforwardly reducible to physical properties. (shrink)

It is frequently alleged that a round plate viewed from an oblique angle looks elliptical, and that when one tree is in front of another that is the same intrinsic size, the front one looks larger than the rear one. And yet there is also a clear sense in which the plate viewed from an angle looks round, and a clear sense in which the two trees look to be the same size. According to the Dual Content Theory (DCT), what (...) explains these and other similar phenomena is that perceptual experiences present us with two different sorts of spatial properties: intrinsic and perspectival spatial properties. I will argue that the Dual Content Theory is false because it rests on flawed phenomenological descriptions of the experience of spatial properties. The only conditions under which a plate tilted away and an ellipse look alike, or two objects which are different in size look the same size, is when at least one of the objects being compared is misperceived. I will consider several responses to the arguments I present, and conclude by suggesting that abandoning DCT would constitute an improvement upon Noë’s enactive theory of perception. (shrink)

A small, insignificant-looking intellectual with absurdly long legs, Søren Kierkegaard (1813-1855) was a veritable Hans Christian Andersen caricature of a man. A strange combination of witty cosmopolite and melancholy introvert, he spent years writing under a series of fantastical pseudonyms, lavishing all the splendor of his magnificent mind on a seldom-appreciative world. He had a tragic love affair with a young girl, was dominated by an unforgettable Old Testament father, fought a sensational literary duel with a popular satiric magazine, and (...) died in the midst of a violent quarrel with the state church for which he had once studied theology. Yet this iconoclast produced a number of brilliant books that have profoundly influenced modern thought. In this classic biography, the celebrated Kierkegaard translator Walter Lowrie presents a charming and warmly appreciative introduction to the life and work of the great Danish writer. Lowrie tells the story of Kierkegaard's emotionally turbulent life with a keen sense of drama and an acute understanding of how his life shaped his thought. The result is a wonderfully informative and entertaining portrait of one of the most important thinkers of the past two centuries. This edition also includes Lowrie's wry essay "How Kierkegaard Got into English," which tells the improbable story of how Lowrie became one of Kierkegaard's principal English translators despite not learning Danish until he was in his 60s, as well as a new introduction by Kierkegaard scholar Alastair Hannay. (shrink)

L'etude menee par Walter Biemel ne pretend nullement isoler et epuiser un concept de la philosophie de Heidegger, mais s'attache tout au contraire a suggerer une interpretation originales d'une pensee a partir de l'un de ses concepts fondamentaux. Pour saisir le probleme du monde, il apparait en effet necessaire de comprendre la structure fondamentale du Dasein. Que la problematique du monde soit intimement liee a celle de l'Etre, c'est ce qui se manifeste clairement dans la definition que donne Heidegger (...) du Dasein, au troisieme chapitre de Sein und Zeit, comme etre-dans-le-monde. De la comprehension de cette modalite d'etre ve dependre la saisie adequate des elements structurels du Dasein. Walter Biemel releve l'importance de cette nouvelle facon de concevoir le Dasein et le changement qu'elle apporte par rapport a la conception traditionnelle partant de l'ego pur. L'expression etre-dans-le-monde, loin de se resumer a une constatation de fait, possede pour Heidegger la signification d'une these ontologique. Bien plus qu'une simple determination spatiale s'epuisant dans l'extensio cartesienne, il s'agit la d'une attitude de familiarite, qui se decline selon divers types de reference du Dasein au monde. Etre-dans-le-monde signifie au fond: etre ouvert a l'Etre, se trouver placer dans l'eclaircie de l'Etre. (shrink)

Neuroscientific evidence has educated us in the ways in which the brain mediates our thought and behavior and, therefore, forced us to critically examine how we conceive of free will. This volume, featuring contributions from an international and interdisciplinary group of distinguished researchers and scholars, explores how our increasing knowledge of the brain can elucidate the concept of the will and whether or to what extent it is free. It also examines how brain science can inform our normative judgments of (...) moral and criminal responsibility for our actions. Some chapters point out the different respects in which mental disorders can compromise the will and others show how different forms of neuromodulation can reveal the neural underpinning of the mental capacities associated with the will and can restore or enhance them when they are impaired. (shrink)

Advances in genetic technology in general and medical genetics in particular will enable us to intervene in the process of human biological development which extends from zygotes and embryos to people. This will allow us to control to a great extent the identities and the length and quality of the lives of people who already exist, as well as those we bring into existence in the near and distant future. Genes and Future People explores two general philosophical questions, one metaphysical, (...) the other moral: (1) How do genes, and different forms of genetic intervention (gene therapy, genetic enhancement, presymptomatic genetic testing of adults, genetic testing of preimplantation embryos), affect the identities of the people who already exist and those we bring into existence? and (2) How do these interventions benefit or harm the people we cause to exist in the near future and those who will exist in the distant future by satisfying or defeating their interest in having reasonably long and disease-free lives? Genes and Future People begins by explaining the connection between genes and disease, placing genetic within a framework of evolutionary biology. It then discusses such topics as how genes and genetic intervention influence personal identity, what genetic testing of individuals and the knowledge resulting from it entails about responsibility to others who may be at risk, as well as how gene therapy and genetic enhancement can affect the identities of people and benefit or harm them. Furthermore, it discusses various moral aspects of cloning human beings and body parts. Finally, it explores the metaphysical and moral implications of genetic manipulation of the mechanisms of aging to extend the human life span.The aim Genes and Future People is to move philosophers, bioethicists, and readers in general to reflect on the extent to which genes determine whether we are healthy or diseased, our identities as persons, the quality of our lives, and our moral obligations to future generations of people. (shrink)