No consensus yet exists on how to handle incidental fnd-ings in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are fndings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We conclude that researchers (...) have an obligation to address the possibility of discovering IFs in their protocol and communications with the IRB, and in their consent forms and communications with research participants. Researchers should establish a pathway for handling IFs and communicate that to the IRB and research participants. We recommend a pathway and categorize IFs into those that must be disclosed to research participants, those that may be disclosed, and those that should not be disclosed. (shrink)

This paper surveys the state-of-the-art in machine ethics, that is, considerations of how to implement ethical behaviour in robots, unmanned autonomous vehicles, or software systems. The emphasis is on covering the breadth of ethical theories being considered by implementors, as well as the implementation techniques being used. There is no consensus on which ethical theory is best suited for any particular domain, nor is there any agreement on which technique is best placed to implement a particular theory. Another unresolved problem (...) in these implementations of ethical theories is how to objectively validate the implementations. The paper discusses the dilemmas being used as validating ‘whetstones’ and whether any alternative validation mechanism exists. Finally, it speculates that an intermediate step of creating domain-specific ethics might be a possible stepping stone towards creating machines that exhibit ethical behaviour. (shrink)

ABSTRACT:Global multi-stakeholder initiatives are important instruments that have the potential to improve the social and environmental sustainability of global supply chains. However, they often fail to comprehensively address the needs and interests of various supply-chain participants. While voluntary in nature, MSIs have most often been implemented through coercive approaches, resulting in friction among their participants and in systemic problems with decoupling. Additionally, in those cases in which deliberation was constrained between and amongst participants, collaborative approaches have often failed to materialize. (...) Our framework focuses on two key aspects of these breakdowns: assumptions about the orientation of MSI participants, and the deliberation processes that participants use to engage with each other to create these initiatives and sustain them over time. Drawing from stakeholder and deliberation theories, we revisit the concept of MSIs and show how their deliberative capacity may be enhanced in order to encourage participants to collaborate voluntarily. (shrink)

Poor working conditions remain a serious problem in supplier facilities in developing countries. While previous research has explored this from the developed buyers’ side, we examine this phenomenon from the perspective of developing countries’ suppliers and subcontractors. Utilizing qualitative data from a major knitwear exporting cluster in India and a stakeholder management lens, we develop a framework that shows how the assumptions of conventional, buyer-driven voluntary governance break down in the dilution of buyer power and in the web of factors (...) rooted in suppliers’ traditions, beliefs, local demands and resource dependency. We reveal out how success in governing collaborative global supply chains often falls short within the subcontracting stage, where a stakeholder management mindset is elusive to most participants. We suggest that success in governing collaborative global supply chains is dependent on concepts of stakeholder utility and the presence of shared value that is often at odds with the realities of power, information asymmetry and compliance/reward systems inherent in the non-market coordination of global supply chains. Our findings offer important insights for delineating the concepts of value creation from CSR concepts and practices, and for modifying the basic assumptions of conventional supply chain governance. (shrink)

During the 1980s and 1990s, the debate on the Marxist theory of history centred largely around the work of Robert Brenner’s property-relations-centred construal of it, and G.A. Cohen’s attempt to revive the classical, determinist argument. This article examines two influential arguments by Erik Wright and his colleagues, and by Alan Carling, which acknowledge important weaknesses in Cohen’s work, but which also try to construct a more plausible version of his theory. I show that the attempts to rescue Cohen are largely (...) unsuccessful. And, to the extent that they render the argument plausible, they do so at the cost of turning it, willy-nilly, into a kind of class-struggle theory. I conclude that this spells the demise of the classical version of historical materialism, but also observe that this does not leave us with a voluntaristic understanding of history, as some of its defenders fear. (shrink)

Micro RNAs (miRNAs) have been shown to control many cellular processes including developmental timing in different organisms. The prediction that miRNAs are involved in regulating hox genes of flies and mouse is quite a recent idea and is supported by the finding that mir‐196 represses Hoxb8 gene expression. The non‐coding regions that encode these miRNAs are also conserved across species in the same way as other mechanisms that regulate expression of hox genes. On the contrary, until now no homeotic phenotype, (...) a hallmark of any hox gene mutation, had been associated with any hox miRNA. Recent work on bithorax complex miRNA (miR–iab‐4–5p) shows, for the first time, that miRNAs can lead to homeotic transformation. This miRNA regulates Ultrabithorax (Ubx) and results in the transformation of haltere to wing.1 This study unveils a new complexity and finesse to the regulation of hox gene expression pattern that is needed for determining the anteroposterior body axis in all bilaterians. BioEssays 28: 445–448, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

The framing problematic of this dissertation is the political and epistemological relationship between metropolitan theory and post-colonial narrative. By providing multiple determinations to that problematic, I seek to situate the inventions of post-colonial identity. Using "detour" both as a privileged figure of contemporary theory and as the lived socio-historical experience of post-colonials, I examine the theoretical and political consequences using the former to translate the latter. Placing my own discourse at the limits of theory, I show that the predicament in (...) which contemporary theory finds itself is a result of the reduction of narrative to theory . ;I stage the negotiation between metropolitan theory and post-colonial narratives as an allegory of the post-colonial predicament. Finally, through a critique of certain post-colonial theorists , I plot the limits of the post-colonial space in the First World. I conclude that to invent the post-colonial space as a signifying space, we need to develop a poetics of retour which will be as complex and as ambiguous as the poetics of detour that the post-colonials have been living, narrating, and theorizing. ;Chapter I sets the theoretical context for posing the problem of post-colonial self-fashioning. In Chapter II, I sketch the trajectory of post-colonial detour through a close reading of V. S. Naipaul's The Mimic Men. In Chapter III, I interrogate Homi Bhabha's theory of cultural hybridity as a version of the poetics of detour. In Chapter IV, I offer a characterization of the predicament of theory. In the final chapter, I discuss the uses of theory by post-colonial intellectuals and offer a critique of their politics of cultural description and self-description. I argue that post-colonial theorists have evaded the question of inventing the post-colonial space as a signifying space by rewriting the narrative of their detour as a narrative of diplacement, as immigritude. (shrink)

Articles on Sikh ethos, history, and philosophy.

In their discussion paper of November 2020, Cooket alpresent a draft protocol for navigating circumstances in which emergency services are overwhelmed. Their paper suggests that COVID-related triage decisions should be based on clinical assessment, patient and family consultation, and a range of ethical considerations. In this response, we note that the protocol exhibits an ambiguity that is likely to result in irresolvable dilemmas when put into practice. This ambiguity is exemplified in the paper’s prime ethical imperative (to ‘save more lives (...) and more years of life’), which takes the form of an undefined conjunction whose practical implications are left unspecified. We see this ambiguity in the prime imperative as one manifestation of a broader set of tensions in the protocol. We show that the discipline of human rights provides an essential supplement to the ethical framework on which Cook and colleagues rely, providing a framework for understanding and working through triage dilemmas involving age, discrimination and equality. (shrink)

When learning a new math concept, should learners be first taught the concept and its associated procedures and then solve problems, or solve problems first even if it leads to failure and then be taught the concept and the procedures? Two randomized-controlled studies found that both methods lead to high levels of procedural knowledge. However, students who engaged in problem solving before being taught demonstrated significantly greater conceptual understanding and ability to transfer to novel problems than those who were taught (...) first. The second study further showed that when given an opportunity to learn from the failed problem-solving attempts of their peers, students outperformed those who were taught first, but not those who engaged in problem solving first. Process findings showed that the number of student-generated solutions significantly predicted learning outcomes. These results challenge the conventional practice of direct instruction to teach new math concepts and procedures, and propose the possibility of learning from one's own failed problem-solving attempts or those of others before receiving instruction as alternatives for better math learning. (shrink)

I take friendship to be a practical and emotional relationship marked by mutual and (more-or-less) equal goodwill, liking, and pleasure. Friendship can exist between siblings, lovers, parent and adult child, as well as between otherwise unrelated people. Some friendships are valued chiefly for their usefulness. Such friendships are instrumental or means friendships. Other friendships are valued chiefly for their own sakes. Such friendships are noninstrumental or end friendships. In this paper I am concerned only with end friendships, and the challenge (...) they pose to consequentialism. In an end friendship, one loves the friend as an essential part of one's system of ends, and not solely, or even primarily, as a means to an independent end - career advancement, amusement, philosophical illumination, or greater happiness in the universe. In such love, one loves the friend for the person she is, i.e., for her essential rather than incidental features. These include both her character traits - the fundamental intellectual, psychological, moral, and aesthetic qualities that constitute an individual's personality - and her unique perspective on herself and others: her view of the important and unimportant, her interest in herself and others. Thus in end friendship the friend cannot be replaced by another, for no other can have her essential features. Nor can she be replaced by a more efficient means to one's ends, or abandoned on their achievement, for it is not as a means that one 2 loves her. It is this necessary irreplaceability that most obviously marks off end friendship from means or instrumental friendship, in which the friend is replaceable.i Hence to love a friend as an end is to place a special value on her - to believe that her value is not outweighed, say, simply by the greater needs of others - or the needs of a greater number of others ("Sorry dear, there are more drowning on this end").ii End friendship (hereafter simply "friendship") is a cardinal human value.. (shrink)

This article discusses the importance of ‘public conscience’ in B. R. Ambedkar’s political thought. Ambedkar consistently defended public conscience as a democratic value in his writings and speeches. Public conscience referred to collective responsibility, social justice and the public deliberation of what constitutes the social good. Ambedkar consistently expressed the unequivocal belief that public conscience would bring about a moral transformation in Indian society through a collective ethical stance against all forms of social oppression. He conceptualized public conscience as a (...) method by which a democratic and ethical Indian society could come about and flourish. This article interrogates his ideas concerning public conscience through a detailed reading of his works, focusing particularly on his 1943 speech, Ranade, Gandhi and Jinnah. (shrink)

The term ‘communitarianism’ is often identified with ‘altruism’: an individual is taken to be communitarian-minded if he or she is concerned with the well-being of others, and not only with his or her own well-being. While communitarianism may embrace altruism, it is most appositely viewed as having a broader connotation. Consider, for example, the puzzle of voting behaviour, discussed by Amitai Etzioni and many others ). Casting one's vote entails a cost, albeit usually a small one: however, if there are (...) large numbers voting, then one's own vote has a negligible effect on the outcome. An altruist might therefore rationally refrain from voting, since he incurs a cost, and neither he nor anybody else receives a benefit. And yet, millions of people the world over regularly vote in elections. Other examples could also be given. ‘Group-oriented’ behaviour has been the focus of a number of recent studies. C. Clague, for example, examines the roles of guilt and shame in discouraging tax evasion, and informally discusses how social influences may affect the strength of these sentiments. R. Naylor and M. Cripps examine the influence of social custom on individuals' propensity to join trade unions, while P. Nelson argues that in choosing which party to vote for people assign some weight to the preferences of persons they associate with. (shrink)

In her recent work, Nancy Folbre undertakes an ambitious effort: constructing an intersectional political economy that aims to identify the common mechanisms and logic underpinning the many wrongs that characterise capitalism. In this paper, we focus on what we deem the three fundamental theoretical pillars of her approach. First, she challenges the oppression/exploitation distinction within Marxian political economy and proposes a broader definition of exploitation that can take manifold forms. Second, she questions the Marxian concept of class, and emphasises the (...) variety of forms of subordination and exploitation related to social identities that cannot be reduced to Marxian classes. Finally, she advocates a more comprehensive notion of the economy beyond a focus on capitalist relations of production. It is difficult to understate the theoretical relevance of these claims, which highlight the importance of various contemporary forms of injustice—of which the exploitation of workers by capitalists is only one. As a complement to the Marxian theory of exploitation and class, Folbre’s approach would broaden our understanding of oppressive social relations. Yet as an alternative to Marxian political economy, it is ultimately unconvincing: a shift of emphasis to ‘manifold exploitations’, social groups, and the economy does not yield a gain in analytical insight but rather an impoverishment of our conceptual toolbox. The struggle against capitalism is different from the struggle against patriarchy and racism, even if the ultimate aim should be the removal of all structures of oppression and domination. (shrink)

Adequate reprogramming of cellular metabolism in response to stresses or suboptimal growth conditions involves a myriad of coordinated changes that serve to promote cell survival. As protein synthesis is an energetically expensive process, its regulation under stress is of critical importance. Reprogramming of messenger RNA (mRNA) translation involves well‐understood stress‐activated kinases that target components of translation initiation machinery, resulting in the robust inhibition of general translation and promotion of the translation of stress‐responsive proteins. Translational arrest of mRNAs also results in (...) the accumulation of transcripts in cytoplasmic foci called stress granules. Recent studies focus on the key roles of transfer RNA (tRNA) in stress‐induced translational reprogramming. These include stress‐specific regulation of tRNA pools, codon‐biased translation influenced by tRNA modifications, tRNA miscoding, and tRNA cleavage. In combination, signal transduction pathways and tRNA metabolism changes regulate translation during stress, resulting in adaptation and cell survival. This review examines molecular mechanisms that regulate protein synthesis in response to stress. (shrink)

The main objective of my dissertation is twofold: (i) to investigate how the problem of moral motivation occurs in Kant’s texts, and (ii) to examine how Kant’s account of moral feeling serves as an appropriate solution to it. First, I argue that the problem of moral motivation occurs in Kant’s texts as a skeptical problem concerning the motivational efficacy of practical reason. My view that this problem is integral to Kant’s main ethical project goes against a scholarly trend that dismisses (...) the philosophical significance of motivational skepticism in Kant’s moral theory. Second, I argue that Kant develops a peculiar notion of moral feeling in his Critique of Practical Reason primarily to resolve the problem of motivational skepticism about pure practical reason. In doing so, I regard the notion of moral feeling as an essential component of both Kant’s moral motivational structure and his justification of the moral law. This inclusion of moral feeling makes my interpretation a better alternative not only to standard transcendental interpretations of Kant’s account of moral motivation, but also to other kinds of interpretations proposed in the recent literature. (shrink)

How engineers know, and act on that knowledge, has a profound impact on society. Consequently, the analysis of engineering knowledge is one of the central challenges for the philosophy of engineering. In this article, we present a thematic multidisciplinary conceptual survey of engineering epistemology and identify key areas of research that are still to be comprehensively investigated. Themes are organized based on a survey of engineering epistemology including research from history, sociology, philosophy, design theory, and engineering itself. Five major interrelated (...) themes are identified: the relationship between scientific and engineering knowledge, engineering knowledge as a distinct field of study, the social epistemology of engineering, the relationship between engineering knowledge and its products, and the cognitive aspects of engineering knowledge. We discuss areas of potential future research that are underdeveloped or “undone.”. (shrink)

A challenge to Kant’s less known duty of self-knowledge comes from his own firm view that it is impossible to know oneself. This paper resolves this problem by considering the duty of self-knowledge as involving the pursuit of knowledge of oneself as one appears in the empirical world. First, I argue that, although Kant places severe restrictions on the possibility of knowing oneself as one is, he admits the possibility of knowing oneself as one appears using methods from empirical anthropology. (...) Second, I show that empirical knowledge of oneself is fairly reliable and is, in fact, considered as morally significant from Kant’s moral anthropological perspective. Taking these points together, I conclude that Kant’s duty of self-knowledge exclusively entails the pursuit of empirical self-knowledge. (shrink)

Lawrence Haworth's book, Autonomy, discusses “Autonomy as a Psychological Idea”, and “Autonomy as a Normative Idea”. Part 1 discusses autonomy in relation to rationality, agency, and responsibility, defends it against Skinnerian sceptics, and outlines a theory of autonomous decision-making and the autonomous task environment. Haworth's conception of autonomy integrates and builds on the concepts of S. I. Benn, G. Dworkin, H. Frankfurt, and R. W. White. Part 2 centres on social/political theory, and not, despite the book's subtitle, on ethics as (...) such. Haworth argues that only autonomy, and not liberty or happiness, is an intrinsic value, and fundamental right. His “autonomist” theory of liberty rights, a form of revisionary liberalism derived from the later idealists, is opposed to the classical liberal/libertarian theory. The arguments prompt a re-examination of the role of autonomy in the arguments for liberty, but do not, in my view, make a persuasive case for “autonomism” against classical liberalism. The book is chiefly noteworthy for its success in covering many important topics connected with autonomy, in an impressively short space, and in an always clear and often very insightful way. (shrink)

This essay explores the ways in which the definition of Indian culture has become a site of contest, and how this contest played out in the controversy that erupted over the release and screening of Deepa Mehta's diasporic film, Fire, in India. I locate this controversy within the broader controversies that are taking place over culture, particularly when issues of sex and sexuality are involved. The continuous targeting of representations of sex and sexuality, betrays an underlying fear that sex is (...) something that is threatening to Indian cultural values, to the Indian way of life, to the very existence of the Indian nation. I discuss the responses to the release of the film by the forces of the Hindu Right as well as feminist and lesbian groups and critique the uncomplicated understandings of culture that informed these positions. Contingent upon these responses rests the story in Fire and the way in which the lesbian subject, a sexual subaltern, is constructed in the cultural space represented in the film. I challenge the positions that suggest that the women are represented as victims in the film, and draw attention to the cultural, sexual and familial ruptures brought about by the main protagonists through their desire for one another. I explore the complicated understandings of agency and desire that are represented through the assertion of this relationship. (shrink)

In this paper, I aim to resolve the Frierson-Grenberg debate on the nature of Kant’s account of moral motivation that took place in the third issue of Con-textos Kantianos. In their respective interpretations, Frierson and Grenberg fail to accommodate the a priori status of moral feeling when incorporating it into Kant’s moral motivational structure. In response, I provide a novel transcendental interpretation – one that takes the a priori moral feeling both as an incentive of morality and as that which (...) conditions the possibility of morality in human agents. I argue that Kant developed the notion of moral feeling solely in order to resolve the problem of motivational skepticism concerning the moral law. Since this problem occurs as a part of Kant’s search for the supreme principle of morality, the notion of moral feeling becomes a part of both Kant’s moral motivational structure and his argument to justify the moral law. (shrink)

This article is a step towards a rethinking of the emergence of the modern state in Europe. Traditionally, war has been viewed as the central mechanism of state formation. This approach claims that war caused the emergence of the modern state in two significant ways: 1) by consolidating the politically fragmented world of the middle ages through conquest; and 2) through the pressure of competition in a Darwinian international system, which forced the polities of Europe to create the bureaucratic structures (...) fundamental to the authority of the modern state. This article seeks to undermine the first of these mechanisms by showing that the territorial consolidation of Europe was a logical result of dynastic lordship. I seek to show that the consolidation of territory and authority into fewer and fewer hands was a direct consequence of dynastic successional practices and therefore that the emphasis on coercion in European political development has been overplayed. (shrink)

Although there is such a thing as Indian thought, it seems to play no role in the way social sciences and philosophy are practiced in India or elsewhere. The problem is not only that we no longer employ terms such as atman, avidya, dharma to reflect on our experience; the terms that we do indeed use—sovereignty, secularism, rights, civil society and political society, corruption—seem to insulate our experience from our reflection. This paper will outline Gandhi’s framing of our predicament in (...) Hind Swaraj. It will then discuss three very different examples taken from our peculiar life with concepts that will also serve to clarify and illustrate the framework I am outlining. It will then very briefly discuss how Gandhi saw the Gita as showing him a way out of the predicament. (shrink)

This is an excellent book but it lacks a detailed presentation and formulation of images of memory. Positron emission tomography (PET) findings sometimes raise more enigmatic questions than they answer, with differences between studies and differences with established lesion evidence. Perhaps the book could have been more critical in its analysis of these enigmas, covering more of the basic issues and assumptions underlying PET research.

Philosophy and Phenomenological Research is currently published by International Phenomenological Society.

This Article examines how the legal subjectivity of the migrant subject is intimately connected to the construction of the citizenship subject and how both have been products of the colonial encounter. Deploying the lens of postcolonialism, I argue that the migrant is addressed through a spectrum of legal rules based on normative criteria reminiscent of the colonial encounter. These criteria reinscribe citizenship within dominant racial, sexual, and cultural norms as well as claims of civilizational superiority. That which does not fall (...) within the boundaries of citizenship is regarded as outcast, an "Other," and subject to restraint, persecution, censorship, social stigma, incarceration, and even annihilation. The discussion draws examples from recent judicial decisions in the context of postcolonial India, dealing with migrant bar dancers and migrant Muslims, highlighting the deep and lasting impact of the colonial encounter and the imperial imagination on understandings and constructions of citizenship in the contemporary period. The cases further illustrate how notions of "global" or "world" citizen, unbound by territory or the nation-state, are unable to account for the complex and contradictory understandings of citizenship that have emerged from within a postcolonial context. The arguments force us to inquire into the role of citizenship, its relevance or meaninglessness in the lives of the migrant once its exclusionary potential has been exposed. (shrink)

Kant’s theory of moral action faces a serious difficulty concerning motivation: how do commands of pure practical reason solely move human agents to perform moral actions? In his response, Kant claims that human agents perform moral actions out of a feeling of respect for the moral law. However, attempts to accommodate a feeling of respect into Kant’s rigorously rationalist ethical theory have led to two diverging strands of interpretation in the secondary literature: intellectualism and affectivism. Against this context, this paper (...) proposes an interpretation of Kantian moral motivation with an appropriate place for the notion of respect within it to resolve the motivational problem concerning moral actions. According to the model of Kantian moral motivation that this paper develops, motivation to act morally takes place in two sequential stages, each involving the positive role of respect as a motive. By arguing for a positive role of the feeling of respect in the process of moral motivation, this model aligns with the affectivist school of interpretation. (shrink)

Between 1983 and 2006 there were two distinct sorts of historical writings on Southeast Asian medical history, with quite different emphases. Some historians focused on the history of medicine in national contexts—a practice that resulted in the neglect of larger socioeconomic factors such as migration—that affected the trajectory of pandemics. At the same time, pursuing a different line of thinking, another group of historians focused on the history of specific diseases from a demographic perspective. These two approaches led to very (...) different conclusions about the nature of epidemic disease and pandemics that have beset the region since the nineteenth century. Nevertheless, regional histories of health are neglected in Southeast Asian medical history in favor of either local, national, or global histories. In this essay, I argue that if historians of global health have forsaken the region in favor of the wider world, Southeast Asian historians have neglected the region in favor of the nation. What is missing in Southeast Asian medical history is a regional perspective that would help understand the ways in which pandemic responses are shaped by colonial, Cold War, or national concerns. Beginning 2019, some historians and political analysts trying to understand global pandemics have adopted a regional approach by treating, as a monolithic group, the ASEAN—the Association of Southeast Asian Nations, which is a regional grouping of Southeast Asian member states, established in 1967. By contrast, others explore specific geographic, political, or economic issues that have contributed to either the spread or containment of disease. In this regard, the COVID-19 crisis in Southeast Asia merits historical attention to comprehend the strengths and weaknesses of a regional approach. (shrink)

Introduction: The Nature and Signif1cance of Friendship Neera Kapur Badhwar Philosophers have long recognized that friendship plays a central role in a ...