Adequate reprogramming of cellular metabolism in response to stresses or suboptimal growth conditions involves a myriad of coordinated changes that serve to promote cell survival. As protein synthesis is an energetically expensive process, its regulation under stress is of critical importance. Reprogramming of messenger RNA (mRNA) translation involves well‐understood stress‐activated kinases that target components of translation initiation machinery, resulting in the robust inhibition of general translation and promotion of the translation of stress‐responsive proteins. Translational arrest of mRNAs also results in (...) the accumulation of transcripts in cytoplasmic foci called stress granules. Recent studies focus on the key roles of transfer RNA (tRNA) in stress‐induced translational reprogramming. These include stress‐specific regulation of tRNA pools, codon‐biased translation influenced by tRNA modifications, tRNA miscoding, and tRNA cleavage. In combination, signal transduction pathways and tRNA metabolism changes regulate translation during stress, resulting in adaptation and cell survival. This review examines molecular mechanisms that regulate protein synthesis in response to stress. (shrink)

1. Aretè : idei i obrazi v sbornata dobrodetelnost -- 2. Aretè : ekzistent︠s︡ialno-t︠s︡ennostna sistema -- 3. Aretè : obuchenie i vŭzpitanie na lidera -- 4. Aretè : upravlenie na dŭrzhavnostta i sigurnostta -- 5. Aretè v muzei︠a︡ : razvitie v strukturata i upravlenieto na evropeĭskii︠a︡ istoricheski muzeĭ -- 6. Avtoreferat na Aretè-logii︠a︡ : knigi I-V.

Монография посвящена анализу и описанию феномена актуального членения предложения как текстовой и как языковой реальности. Подробно на примерах описывается комплекс языковых средств ремовыделения в португальском и русском языках.

It is shown that for every Turing degree d there is an ω-categorical group G such that the isomorphism type of G is of degree d. We also find an ω-categorical group G such that the isomorphism type of G has no degree.

Libertarian philosophy asserts that only the initiation of physical force against persons or property, or the threat thereof, is inherently illegitimate. A corollary to this assertion is that all forms of speech, including fraudulent advertising, are not invasive and therefore should be considered legitimate. On the other hand, fraudulent advertising can be viewed as implicit theft under the theory of contract: if a seller accepts money knowing that his product does not have some of its advertised characteristics, he acquires the (...) property title to the customer’s money without voluntary consent, which is theft. The balance between these two logical extensions of property rights—the right of free speech and the right of contract—lies somewhere in the area of communication philosophy, and can be explained through understanding the role of communication in human interactions. Advertising is a form of communication that may convey important information about the conditions of the proposed contract. These conditions are expressed in particular words that may have different meanings in different circumstances. Therefore to determine whether a particular example or “misinterpretation” is mere sophistry or a type of fraud, the judicial system has to approach each issue on a case-by-case basis. The border between legal and illegal should be determined by precedents and by expectations based on commonly accepted definitions of terms—what people commonly understand by the words and other forms of communication they use. (shrink)

I. The framework. 1, Aristotle's project and methods. 2, The perceptual capacity of the soul. 3, The sensory apparatus. 4, The common sense and the related capacities -- II. The terminology. 1, Overlooked occurrences of the phrase 'common sense'. 2, De anima III.1 425a27. 3, De partibus animalium IV.10 686a31. 4, De memoria et reminiscentia 1 450a10. 5, De anima III.7 431b5. 6, Conclusions on the terminology -- III. Functions of the common sense. 1, Simultaneous perception and cross-modal binding. 2, (...) Perceptual discrimination. 3, Waking, sleep, and control of the senses. 4, Perceiving that what we see and hear, and monitoring of the senses. 5, Other roles of the common sense -- Conclusion. (shrink)

Out of the broad variety of Cusanus' work, this book discusses six of his writings, careful not to isolate them from the whole of his work. It instead presents them against the maturation of Cusanus' thinking as it developed from his first sermons up to his shortest philosophical text De apice theoriae. The texts in question are De docta ignorantia, De coniecturis, Idiota de mente, De beryllo, Trialogus de possest and De apice theoriae. In the search for God, or rather (...) in Cusanus' lifetime eff orts to have his spirit touch the fi rst principle and the basis of all things, new perspectives on the world and man within would open up for Cusanus. Respecting this basic intention of Cusanus' thinking, the author primarily deals with Cusanus' ontotheological (metaphysical) claims and, in their context, turns his attention to the cosmological, or anthropologico-gnoseological opinions. (shrink)

In my comment on Katerina Ierodiakonou’s paper, I outline my understanding of the programme of De anima and how it bears on Aristotle’s discussion of the transparent in De anima 2.7, in contrast with his discussion of the transparent in De sensu 3. I then explore Aristotle’s notion of transparency and sketch an alternative to Ierodiakonou’s interpretation of Aristotle’s views as to how colours are generated in physical objects. At the end, I raise two objections to Alexander’s interpretation of the (...) transparent as discussed by Ierodiakonou. (shrink)

The study provides an insight into the structural features of the famous VIII century Buddhist treatise Tattvasaṅgrāha by Śāntarakṣita with regard to the text’s main purpose ( prayojana ) as it is treated in Kamalaśīla’s commentary Pañjikā. Any text along with its referential (representational) function of conveying message - meaning to the addressee, or its expressive function, reflecting the author's attitude to what is communicated, also performs the ‘appellative’ function, encouraging the recipient of the message to act. This function which (...) could also be called praxiological was always significant in Indian text culture, since from the times of Veda-s it was embedded in its very core. This function is of paramount importance in the case of Indian religious and philosophical texts, whose main aim is to convince and transform the consciousness of their percipients. Along with linear models of message transfer, Sanskrit texts could demonstrate non-linear semantic structures, transmitting the main idea of the text indirectly. It is exactly how one should perceive the message of Śāntarakṣita’s Tattvasaṅgrāha according to the suggested by Śāntarakṣita’s prominent student Kamalaśīla in his Pañjikā -commentary to the treatise. He proposes to consider Tattvasaṅgrāha not as a thematically heterogeneous encyclopaedic or doxographic work, whose main objective is to refute different non-Buddhist views (as it is often treated by scholars now), but as a text, which by its very design exposes one of the most important Buddhist principles - the law of the dependent origination ( pratītyasamutpāda ). The themes, discussed in a number of the chapters of Tattvasaṅgrāha, indeed, appear to have direct correlation with the characteristics of pratītyasamutpāda given to it in Śālistamba-sūtra - an early Mahāyāna text, which explains this universal law. Kamalaśīla suggests looking at Tattvasaṅgrāha as at one big unit-sentence - mahāvākya, with the exposition of pratītyasamutpāda as its unitary purpose-meaning ( abhidheya ). In this context, the treatise functions as a praxiological tool for the ‘installing’ into the consciousness of the text’s addressee the knowledge of ‘true principles’ (tattva-s) of pratītyasamutpāda. This interpretation of the main message of the text raises also a question of the adequate translation of the name of the treatise into other languages, because, according to Kamalaśīla, ‘ Tattvasaṅgrāha’ means the ‘Assembly of Principles-(tattva’-s)’ which specify precisely pratītyasamutpāda (pratītyasamutpāda-viśeṣaṇāni tattvāni). (shrink)

Kniha obsahuje články, studie, úvahy a memoárové texty, publikované v různých časopisech a sbornících v letech 1971 až 2010.

In this paper we discuss the two-system framework, examine its strengths, point out a fundamental weakness concerning the unity of conscious experience, and then propose a new hypothesis that avoids that weakness and other related concerns. According to our strong emergence hypothesis, what emerges are not merely mental properties in specialized, distributed neural areas, but also a new, irreducibly singular entity that functions in a recurrent manner to integrate its mental properties and to rewire its brain. We argue that the (...) former function is suggested, in part, by the effects of anesthetics on sensory integration, and that the latter function is suggested by evidence garnered from the neuroscience of mindfulness, constraint-induced movement therapy for stroke, and neuroimaging data surrounding mental illness. We then discuss how our strong emergence hypothesis relates to the description and treatment of neuropsychiatric disorders. Finally, potential objections are addressed. (shrink)

Chapter One: Constructions. Entities, constructions, and functions When one travels from Los Angeles to New York, going, say, by way of St. Louis, Chicago, ...

The central focus of this book is the concept of higher education reform in the light of an international and global comparative perspective. After decades of far-reaching reform, higher education around the world has profoundly changed and now has to face the challenges of the present. This volume takes a close look at these changes, the drivers of change, their effects and possible future scenarios. In their contributions the authors discuss a variety of basic concepts: learning and teaching in higher (...) education; financing and quality assurance; governance change; massification vs. equity and equality; internationalization and mobility, the implementation of lifelong structures in higher education. (shrink)

Traxler, Pickering, and Clifton found that ambiguous sentences are read faster than their unambiguous counterparts. This so-called ambiguity advantage has presented a major challenge to classical theories of human sentence comprehension because its most prominent explanation, in the form of the unrestricted race model, assumes that parsing is non-deterministic. Recently, Swets, Desmet, Clifton, and Ferreira have challenged the URM. They argue that readers strategically underspecify the representation of ambiguous sentences to save time, unless disambiguation is required by task demands. When (...) disambiguation is required, however, readers assign sentences full structure—and Swets et al. provide experimental evidence to this end. On the basis of their findings, they argue against the URM and in favor of a model of task-dependent sentence comprehension. We show through simulations that the Swets et al. data do not constitute evidence for task-dependent parsing because they can be explained by the URM. However, we provide decisive evidence from a German self-paced reading study consistent with Swets et al.'s general claim about task-dependent parsing. Specifically, we show that under certain conditions, ambiguous sentences can be read more slowly than their unambiguous counterparts, suggesting that the parser may create several parses, when required. Finally, we present the first quantitative model of task-driven disambiguation that subsumes the URM, and we show that it can explain both Swets et al.'s results and our findings. (shrink)

In this article I explore Maimon’s role in the evolution of Kant’s understanding of the function of the history of philosophy in philosophical enquiry. Kant is often viewed as holding an ambivalent...

We give an example of a simple ω-categorical theory such that for any finite set of parameters the corresponding constant expansion does not satisfy the PAPA. We describe a wide class of homogeneous structures with generic automorphisms and show that some natural reducts of our example belong to this class.

2 Popper's Logical Definition of Verisimilitude. 3 Popper's Probabilistic Definition of Verisimilitude. 4 Conclusion.

Roman Catholic and Eastern Orthodox theologians claim that the unique event of Christ’s sacrifice on Calvary is present in Eucharistic liturgies. A popular explanatory strategy for this miraculous presence suggests that due to its supernatural character the Eucharist “conquers time,” transcends its boundaries, and allows for temporal coincidence of two chronologically distant events. I discuss the four main approaches within this strategy that can be discovered in contemporary theological writings. The first approach implies a time travel of the Calvary event. (...) The second suggests the time travel of Eucharistic participants. The third eliminates the chronological distance by relocating one of the events into a timeless reality. The fourth assumes multilocation of the event across time. I argue that each of these approaches is untenable on philosophical or theological grounds. (shrink)