Is synaesthesia cognitively useful? Individuals with time–space synaesthesia experience time units as idiosyncratic spatial forms, and report that these forms aid them in mentally organising their time. In the present study, we hypothesised that time–space synaesthesia would facilitate performance on a time-related cognitive task. Synaesthetes were not specifically recruited for participation; instead, likelihood of time–space synaesthesia was assessed on a continuous scale based on participants’ responses during a semi-structured interview. Participants performed a month-manipulation task, which involved naming every second month (...) or every third month in reverse-chronological order, beginning and ending with a target month. Using hierarchical multiple regression, we found that time–space synaesthesia corresponded with faster performance on both versions of the task. We propose that time–space synaesthesia may expedite the cognitive manipulation of time-based information. Our results also indicate that synaesthesia is far less unusual than widely believed. (shrink)

Moving away from the strong body of critique of pervasive ‘bad data’ practices by both governments and private actors in the globalized digital economy, this book aims to paint an alternative, more optimistic but still pragmatic picture of the datafied future. The authors examine and propose ‘good data’ practices, values and principles from an interdisciplinary, international perspective. From ideas of data sovereignty and justice, to manifestos for change and calls for activism, this collection opens a multifaceted conversation on the kinds (...) of futures we want to see, and presents concrete steps on how we can start realizing good data in practice. (shrink)

Why hasn’t the Marx-inspired Left seized upon catastrophic climate change as the basis for reconceiving historical materialism and the contradictions fueling anticapitalist struggle in the twenty-first century? Defining core participants as energy users and abusers, anchored in the opposition to fossil-fueled profit and growth rather than in traditional class conflicts, the struggle to create a postcapitalist energy commons can become the leading edge of a more broadly conceived global struggle for a sustainable and just postcapitalist society. The new global movement (...) will be enabled by technologies of green energy microproduction, an energy internet for sharing energy on postcapitalist grids, and efforts to create more sustainable community relationships and practices. Catastrophic climate change can become the occasion for reigniting a Marx-inspired sense of transformative agency and solidarity that will enable us to confront transnational capitalism globally and locally in ways that are beyond the imaginative bounds of the current paper. (shrink)

How transcription factors achieve their in vivo specificities is a fundamental question in biology. For the Homeotic Complex (HOM/Hox) family of homeoproteins, specificity in vivo is likely to be in part determined by subtle differences in the DNA binding properties inherent in these proteins. Some of these differences in DNA binding are due to sequence differences in the N‐terminal arms of HOM/Hox homeodomains. Evidence also exists to suggest that cofactors can modify HOM/Hox function by cooperative DNA binding interactions. The Drosophila (...) homeoprotein extradenticle (exd) is likely to be one such cofactor. In HOM/Hox proteins, both the conserved ‘YPWM’ peptide motif and the homeodomain are important for interacting with exd. Although exd provides part of the answer as to how specificity is achieved, there may be additional cofactors and mechanisms that have yet to be identified. (shrink)

In this dissertation, I present Marx's conception of ideology as a counterpart of his critical analysis of society. I take exception to current Marxist notions of ideology, and I attempt to show that they correspond to Marxism's failure to develop an historical, material analysis of contemporary society, and its consequent reliance upon an idealist theory of social change. I am ultimately interested in utilizing Marx's theory of ideological critique as the basis for a return to a materially grounded social criticism. (...) ;The thesis begins with an analysis of Marx's early philosophical investigations, showing his concept of ideology emerge with his recognition of a pattern of philosophical abstractions from social movement. Marx's demonstration that nineteenth century economists reduced political economy to a static theory of social distribution and reproduction is contrasted with his theory of the dynamics of social production. ;Marx's anti-ideological methodology decrees, however, a continuing need to reassess the social organism, digging beneath prominent theoretical abstractions to reveal the processes of historical development immanent in present society. Modern Marxism shirks this responsibility, countering the abstractions of liberal theory with its own tired categories of class struggle and false consciousness, offering a moral critique rather than an alternative conception of capitalism. ;I present Althusser's theory of ideological practices as the basis for a renewed interest in the historically specific structures of present society. It grounds my critique of the ideological assumption, shared by Marxism and liberalism, that economic relations have priority in theories of social transformation. Applying Marx's materialist, historical methodology to the analysis of contemporary social relations, I conclude that a post-Marxist theory, emphasizing noneconomic contradictions as sources of instability and immanent social change, is now warranted. The traditional economic oppositions of class and consciousness have, I maintain, been superseded rather than merely conditioned by noneconomic social antagonisms. (shrink)

William Burnside was one of the three most important algebraists who were involved in the transformation of group theory from its nineteenth-century origins to a deeper twentieth-century subject. Building on work of earlier mathematicians, they were able to develop sophisticated tools for solving difficult problems. His works are of enormous historical importance; they remain also a source of inspiration and information. The works of his contemporaries, such as Klein, Frobenius, Schur, have been published as also have the works of his (...) immediate successors such as Phillip Hall. All of Burnside's papers are reproduced here, organized chronologically and with a detailed bibliography. Walter Feit has contributed a foreword, and a collection of introductory essays are included to provide a commentary on Burnside's work and set it in perspective along with a modern biography that draws on archive material. This is the first reference volume of Burnside's collected papers, enhanced by a series of critical essays on his work, and is important for group theorists and historians and philosophers of mathematics and fills the gap in this area of literature. (shrink)

I examine the ways in which our cultural expectations with respect to death may be transformed by the legalization of assisted suicide. I suggest the inadequacy of the philosophical framework currently taken as the basis for discussing the advantages as well as the dangers of legalizing assisted suicide. I do not believe that individual autonomy is any sort of possibility for dying patients, regardless of the social policies that surround death in a society, insofar as our individual agency in this (...) situation is necessarily intertwined with that of various relevant others. By means of a theory of agency relations, I attempt to show the dynamic ways in which we may all adjust to the option of assisted suicide as a preferred end-of-life option. My theory of agency relations does not deny individual choice; rather it explains the qualitative complexity of individual choice, as well as its dynamic social process of evolving. (shrink)

The evolutionarily conserved genomic organization of the Hox genes has been a puzzle ever since it was discovered that their order along the chromosome is similar to the order of their functional domains along the antero‐posterior axis. Why has this colinearity been maintained throughout evolution? A close look at regulatory sequences from the mouse Hox clusters(1,2) suggests that enhancer sharing between adjacent Hox genes may be one reason. Moreover, characterizing the activity of one of these mouse enhancers in Drosophila(2) illustrates (...) that despite many similarities, not all Hox clusters are built in the same way. (shrink)

How size is controlled during animal development remains a fascinating problem despite decades of research. Here we review key concepts in size biology and develop our thesis that much can be learned by studying how different organ sizes are differentially scaled by homeotic selector genes. A common theme from initial studies using this approach is that morphogen pathways are modified in numerous ways by selector genes to effect size control. We integrate these results with other pathways known to regulate organ (...) size in developing a comprehensive model for organ size control. ©2007 Wiley Periodicals, Inc BioEssays 30:843–853, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

In The City of God , XI, 10, St Augustine claims that the divine nature is simple because ‘it is what it has’ . We may take this as a slogan for the Doctrine of Divine Simplicity , a doctrine which finds its way into orthodox medieval Christian theological speculation. Like the doctrine of God's timeless eternality, the DDS has seemed obvious and pious to many, and incoherent, misguided, and repugnant to others. Unlike the doctrine of God's timeless eternality, the (...) DDS has received very little critical attention. The DDS did not originate with Augustine, but I am not primarily concerned with its pedigree. Nor am I concerned to ask how the doctrine interacts with trinitarian speculation. I will have my hands full as it is. In Section I of this paper I shall provide a rough characterization of the DDS, indicate its complexity, and focus on a particular aspect of the doctrine which will exercise us in the remainder of the paper, namely, the thesis that the divine attributes are all identical with each other and with God. In section n I shall discuss Alvin Plantinga's recent objections to Aquinas' version of the DDS. I shall then offer a more detailed presentation of what I take to be Aquinas' version , and recast it in terms of a theory of attributes which is significantly different from Plantinga's . Although the recasting of the doctrine will enable me to rebut Plantinga's objections , it by no means solves all the problems of the DDS. In section vi I shall discuss the chief lingering problem facing a defender of the DDS. (shrink)

ABSTRACT As a classical philologist, Nietzsche was extremely familiar with the work of many ancient Greek writers. It is well known that Nietzsche made a practice of identifying with and praising ancient thinkers with whom he felt a kinship. It is worth investigating, then, whether Nietzsche's mention of Hippocrates in D signals a sustained interest in the so-called father of medicine. I argue that there is no evidence that Nietzsche paid special attention to Hippocrates or the Hippocratic corpus. Instead, Nietzsche's (...) curious allusion to Hippocrates is likely influenced in part by his reading of the Comtean positivist Émile Littré. Finally, I argue that if Nietzsche is consciously “Hippocratic” at all, he is so in virtue of the “medical posture” he adopts in D, where Nietzsche's remarks suggest his mission is to relieve humankind of the psychological suffering caused by morality. (shrink)

Over the last fifteen years, an ambitious explanatory framework has been proposed to unify explanations across biology and cognitive science. Active inference, whose most famous tenet is the free energy principle, has inspired excitement and confusion in equal measure. Here, we lay the ground for proper critical analysis of active inference, in three ways. First, we give simplified versions of its core mathematical models. Second, we outline the historical development of active inference and its relationship to other theoretical approaches. Third, (...) we describe three different kinds of claim -- labelled mathematical, empirical and general -- routinely made by proponents of the framework, and suggest dialectical links between them. Overall, we aim to increase philosophical understanding of active inference so that it may be more readily evaluated. -/- This the final submitted version of the Introduction to the Topical Collection "The Free Energy Principle: From Biology to Cognition", forthcoming in Biology & Philosophy. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:World Alienation in Feminist ThoughtThe Sublime Epistemology of Emphatic Anti-EssentialismBonnie Mann (bio)The earth is the very quintessence of the human condition.Hannah ArendtWe are tied to place undetachably and without reprieve.Edward CaseyThe alliance between feminism and postmodernism1 in the American academy has brought about a revolution in feminist epistemology. The early feminist epistemology of unmasking, of sorting through appearances to get to the real underneath, has been discredited as "essentialist."2 (...) Feminist standpoint epistemology was an attempt to respond to this accusation by using social location as a "standpoint" from which at least local and situated knowledge could be articulated.3 More recently, many feminists have taken on the epistemology of the simulacrum. Here "the real" plays a part only as that which dissolves into the appearances themselves. Behind the appearances, if there were such a place, would be only an abyss of absence.With this revolution in feminist epistemology comes a wholesale displacement [End Page 45] of the feminist project. Others have argued that the feminist political project is displaced in the alliance with postmodernism.4 On my view, the epistemological and political displacements accompany and instantiate an even deeper level of dispossession. The ultimate price we pay for the feminist alliance with postmodernism may well be a material displacement, in which we are dispossessed of our ability to inquire into and articulate our relationship to the earth itself. We find this planet we inhabit, this physical place that sustains us moment by moment, to be effectively shut out of what now passes as "good" feminist inquiry.In 1958, Hannah Arendt wrote already of "the advent of a new and yet unknown age," marked by world-alienation, a "twofold flight from the earth into the universe and from the world into the self" (1958, 6). The "unknown age" has now been named. Postmodernity takes this flight one step further than Arendt foresaw, however, and even folds the universe and the self into discourse. World-alienation has taken the form of the self-enclosed universe of the text. Our sojourn in the world of signs is so paradigmatic of "the postmodern condition," that asking the question of our relationship to the physical planet we inhabit seems naive and nostalgic. Anything we might say about the earth, after all, is already in language, already bound up in discourse. To speak of an "earth" or "nature" that exceeds discourse is to find oneself locked, even so, within discourse. Having lost our belief in the referentiality of language, in the relation between words and things, we are stuck with signs that refer only to other signs.A capitulation to our very real physical and phenomenological experience of world-alienation finds here its theoretical form. We give in to placelessness. As Edward S. Casey writes, "To say 'I have no place to go' is to admit to a desperate circumstance. Yet we witness daily the disturbing spectacle of people with no place to go: refugees from natural catastrophes or strife-torn countries, the homeless on the streets of modern cities, not to mention 'stray' animals. In fearing that 'the earth is becoming uninhabitable'—a virtual universal lament—we are fearing that the earth will no longer provide adequate places in which to live. The incessant motion of postmodern life in late-capitalist societies at once echoes and exacerbates this fear" (Casey 1993, xiii). Intellectually, we find ourselves in equally desperate circumstances, trapped as we are inside a language that can refer only to itself. This self-enclosure becomes a kind [End Page 46] of no place, a world-alienated space without place,5 and feminist thinking is set adrift from the physical places that give feminist thinkers our moment by moment sustenance. In its alliance with postmodernism, feminism has capitulated to the placelessness that so marks our phenomenological experience at the turn of the millennium.6Yet we inhabit this planet. Faced with its destruction we are compelled to make sense of our relationship to it and to act to save it. A feminist philosophy that turns its back on the earth embraces, rather than contests, the world-alienation of which Arendt spoke. Yet our alienation... (shrink)

The lies about the reasons for the U.S. war against Iraq provoked no mass public outcry in the United States against the war. What is the process of justification for this war, a process that seems to need no reasons? Mann argues that the process of justification is not a process of rational deliberation but one of aesthetic self-constitution, of rebuilding a masculine national identity. Included is a feminist reading of the National Defense University document Shock and Awe.

Aristotle's Categories can easily seem to be a statement of a naïve, pre-philosophical ontology, centered around ordinary items. Wolfgang-Rainer Mann argues that the treatise, in fact, presents a revolutionary metaphysical picture, one Aristotle arrives at by (implicitly) criticizing Plato and Plato's strange counterparts, the "Late-Learners" of the Sophist. As Mann shows, the Categories reflects Aristotle's discovery that ordinary items are things (objects with properties). Put most starkly, Mann contends that there were no things before Aristotle. The author's argument consists of (...) two main elements. First, a careful investigation of Plato which aims to make sense of the odd-sounding suggestion that things do not show up as things in his ontology. Secondly, an exposition of the theoretical apparatus Aristotle introduces in the Categories--an exposition which shows how Plato's and the Late-Learners' metaphysical pictures cannot help but seem inadequate in light of that apparatus. In doing so, Mann reveals that Aristotle's conception of things--now so engrained in Western thought as to seem a natural expression of common sense--was really a hard-won philosophical achievement. Clear, subtle, and rigorously argued, The Discovery of Things will reshape our understanding of some of Aristotle's--and Plato's--most basic ideas. (shrink)

: The lies about the reasons for the U.S. war against Iraq provoked no mass public outcry in the United States against the war. What is the process of justification for this war, a process that seems to need no reasons? Mann argues that the process of justification is not a process of rational deliberation but one of aesthetic self-constitution, of rebuilding a masculine national identity. Included is a feminist reading of the National Defense University document Shock and Awe.

In lieu of an abstract, here is a brief excerpt of the content:World Alienation in Feminist ThoughtThe Sublime Epistemology of Emphatic Anti-EssentialismBonnie Mann (bio)The earth is the very quintessence of the human condition.Hannah ArendtWe are tied to place undetachably and without reprieve.Edward CaseyThe alliance between feminism and postmodernism1 in the American academy has brought about a revolution in feminist epistemology. The early feminist epistemology of unmasking, of sorting through appearances to get to the real underneath, has been discredited as "essentialist."2 (...) Feminist standpoint epistemology was an attempt to respond to this accusation by using social location as a "standpoint" from which at least local and situated knowledge could be articulated.3 More recently, many feminists have taken on the epistemology of the simulacrum. Here "the real" plays a part only as that which dissolves into the appearances themselves. Behind the appearances, if there were such a place, would be only an abyss of absence.With this revolution in feminist epistemology comes a wholesale displacement [End Page 45] of the feminist project. Others have argued that the feminist political project is displaced in the alliance with postmodernism.4 On my view, the epistemological and political displacements accompany and instantiate an even deeper level of dispossession. The ultimate price we pay for the feminist alliance with postmodernism may well be a material displacement, in which we are dispossessed of our ability to inquire into and articulate our relationship to the earth itself. We find this planet we inhabit, this physical place that sustains us moment by moment, to be effectively shut out of what now passes as "good" feminist inquiry.In 1958, Hannah Arendt wrote already of "the advent of a new and yet unknown age," marked by world-alienation, a "twofold flight from the earth into the universe and from the world into the self" (1958, 6). The "unknown age" has now been named. Postmodernity takes this flight one step further than Arendt foresaw, however, and even folds the universe and the self into discourse. World-alienation has taken the form of the self-enclosed universe of the text. Our sojourn in the world of signs is so paradigmatic of "the postmodern condition," that asking the question of our relationship to the physical planet we inhabit seems naive and nostalgic. Anything we might say about the earth, after all, is already in language, already bound up in discourse. To speak of an "earth" or "nature" that exceeds discourse is to find oneself locked, even so, within discourse. Having lost our belief in the referentiality of language, in the relation between words and things, we are stuck with signs that refer only to other signs.A capitulation to our very real physical and phenomenological experience of world-alienation finds here its theoretical form. We give in to placelessness. As Edward S. Casey writes, "To say 'I have no place to go' is to admit to a desperate circumstance. Yet we witness daily the disturbing spectacle of people with no place to go: refugees from natural catastrophes or strife-torn countries, the homeless on the streets of modern cities, not to mention 'stray' animals. In fearing that 'the earth is becoming uninhabitable'—a virtual universal lament—we are fearing that the earth will no longer provide adequate places in which to live. The incessant motion of postmodern life in late-capitalist societies at once echoes and exacerbates this fear" (Casey 1993, xiii). Intellectually, we find ourselves in equally desperate circumstances, trapped as we are inside a language that can refer only to itself. This self-enclosure becomes a kind [End Page 46] of no place, a world-alienated space without place,5 and feminist thinking is set adrift from the physical places that give feminist thinkers our moment by moment sustenance. In its alliance with postmodernism, feminism has capitulated to the placelessness that so marks our phenomenological experience at the turn of the millennium.6Yet we inhabit this planet. Faced with its destruction we are compelled to make sense of our relationship to it and to act to save it. A feminist philosophy that turns its back on the earth embraces, rather than contests, the world-alienation of which Arendt spoke. Yet our alienation... (shrink)

There are three lines of argument in defence of coercive treatment of patients with mental disorders: arguments regarding (1) societal interests to protect others, (2) the patients' own health interests, and (3) patient autonomy. In this paper, we analyse these arguments in relation to an idealized case, where a person with a mental disorder claims not to want medical treatment for religious reasons. We also discuss who should decide what in situations where patients with mental disorders deny treatment on seemingly (...) rational grounds.We conclude that, in principle, coercive treatment cannot be defended for the sake of protecting others. While coercive actions can be acceptable in order to protect close family and others, medical treatment is not justified for such reasons but should be given only in the interest of patients. Coercive treatment may be required in order to promote the patient's health interests, but health interests have to waive if they go against the autonomous interests of the patient. We argue that non-autonomous patients can have reasons, rooted in their deeply-set values, to renounce compulsory institutional treatment, and that such reasons should be respected unless it can be assumed that their new predicaments have caused them to change their views. (shrink)

The lies about the reasons for the U.S. war against Iraq provoked no mass public outcry in the United States against the war. What is the process of justification for this war, a process that seems to need no reasons? Mann argues that the process of justification is not a process of rational deliberation but one of aesthetic self-constitution, of rebuilding a masculine national identity. Included is a feminist reading of the National Defense University document Shock and Awe.

When making substituted judgments for incapacitated patients, surrogates often struggle to guess what the patient would want if they had capacity. Surrogates may also agonize over having the (sole) responsibility of making such a determination. To address such concerns, a Patient Preference Predictor (PPP) has been proposed that would use an algorithm to infer the treatment preferences of individual patients from population-level data about the known preferences of people with similar demographic characteristics. However, critics have suggested that even if such (...) a PPP were more accurate, on average, than human surrogates in identifying patient preferences, the proposed algorithm would nevertheless fail to respect the patient’s (former) autonomy since it draws on the ‘wrong’ kind of data: namely, data that are not specific to the individual patient and which therefore may not reflect their actual values, or their reasons for having the preferences they do. Taking such criticisms on board, we here propose a new approach: the Personalized Patient Preference Predictor (P4). The P4 is based on recent advances in machine learning, which allow technologies including large language models to be more cheaply and efficiently ‘fine-tuned’ on person-specific data. The P4, unlike the PPP, would be able to infer an individual patient’s preferences from material (e.g., prior treatment decisions) that is in fact specific to them. Thus, we argue, in addition to being potentially more accurate at the individual level than the previously proposed PPP, the predictions of a P4 would also more directly reflect each patient’s own reasons and values. In this article, we review recent discoveries in artificial intelligence research that suggest a P4 is technically feasible, and argue that, if it is developed and appropriately deployed, it should assuage some of the main autonomy-based concerns of critics of the original PPP. We then consider various objections to our proposal and offer some tentative replies. (shrink)

Down Girl is a broad, original, and far ranging analysis of what misogyny really is, how it works, its purpose, and how to fight it. The philosopher Kate Manne argues that modern society's failure to recognize women's full humanity and autonomy is not actually the problem. She argues instead that it is women's manifestations of human capacities -- autonomy, agency, political engagement -- is what engenders misogynist hostility.