Werner syndrome (WS) is an inherited disorder that produces somatic stunting, premature ageing and early onset of degenerative and neoplastic diseases. Cultured fibroblasts derived from subjects with WS are found to undergo premature replicative senescence and thus provide a cellular model system to study the disorder. Recently, several overexpressed gene sequences isolated from a WS fibroblast cDNA library have been shown to possess the capacity to inhibit DNA synthesis and disrupt many normal biochemical processes. Because a similar constellation of genes (...) is overexpressed in WS and senescent normal fibroblasts, these data suggest the existence of a common molecular genetic pathway for replicative senescence in both types of cell. We propose that the primary defect in WS is a mutation in a gene for a trans‐acting repressor protein that reduces its binding affinity for shared regulatory regions of several genes, including those that encode inhibitors of DNA synthesis (IDS). The mutant WS repressor triggers a sequence of premature expression of IDS and other genes, with resulting inhibition of DNA synthesis and early cellular senescence, events which occur much later in normal cells. (shrink)

How do we align the distinct neural patterns associated with the articulation and the acoustics of the same utterance in order to guide behaviors that demand sensorimotor interaction, such as vocal learning and the use of feedback during speech production? One hypothesis is that while the representations are distinct, their patterns of change over time (temporal modulation) are systematically related. This hypothesis is pursued in the exploratory study described here, using paired articulatory and acoustic data from the X-ray microbeam corpus. (...) The results show that modulation in both articulatory movement and in the changing acoustics has the form of a pulse-like structure related to syllable structure. The pulses are aligned with each other in time, and the modulation functions are robustly correlated. These results encourage further investigation and testing of the hypothesis. (shrink)

Laurence Goldstein gives a straightforward and lively account of some of the central themes of Wittgenstein's writings on meaning, mind, and mathematics.

Ray Billington explores the spirituality of Eastern thought and its differences from and relationships with the Western religious tradition by presenting the main principles of Hinduism, Buddhism, Taoism, Jainism and Confucianism. Billington discusses the central themes of religious philosophy, comparing Eastern and Western views of belief of God, the soul, moral decision-making, nature, faith and authority. He then challenges theism, particularly Christianity, with its belief in a personal God bestowing a certain version of "truth". He concludes that the universal mysticism (...) characteristic of Eastern thought provides a more realistic and rewarding path. (shrink)

Where much contemporary philosophy seeks to stave off the "threat" of nihilism by safeguarding the experience of meaning--characterized as the defining feature of human existence--from the Enlightenment logic of disenchantment, this book attempts to push nihilism to its ultimate conclusion by forging a link between revisionary naturalism in Anglo-American philosophy and anti-phenomenological realism in recent French philosophy. Contrary to an emerging "post-analytic" consensus which would bridge the analytic-continental divide by uniting Heidegger and Wittgenstein against the twin perils of scientism and (...) skepticism, this book short-circuits both traditions by plugging eliminative materialism directly into speculative realism. (shrink)

Credences are beliefs about evidential probabilities. We give the view an assessment-sensitive formulation, show how it evades the standard objections, and give several arguments in support.

A science of metaphysics adhering to Immanuel Kant's critical demands as set forth in his "Critique of Pure Reason", and "Prolegomena to Any Future Metaphysic...." The work includes an Appendix that quotes Kant's most relevant remarks in this regard, along with his criterion for objective validity that, given the technical jargon, can be next to impossible to interpret even for those most familiar with Kant. The Appendix allows Kant to interpret himself, the point being that many secondary works enter into (...) conflict with Kant. This can be seen most notably with respect to the somewhat understandable notion that Kant was opposed to speculative metaphysics; but Kant's criterion for objective validity undermines this closed-to-speculative-metaphysics interpretation. As a science in the Kantian sense this work (in this latest edition there is a 2/3 page abstract diagram of the science that makes it more conceptually clear) offers an opportunity for those inclinec to shy away from speculative metaphysics to reexamine their interpretations, for as yet there is just as Kant states, no such thing as metaphysics, aside from such a science (Hegel notwithstanding). The objectives are as Kant mentions in the introduction to his CPR: God, Freedom, and Immortality; and that these problems can be dealt with rationally can be seen in this work; and without fear of violating Kant's reasonable and justifiable strictures, the main one being that where anything offered in the name of pure reason is concerned, it must be such that it helps us to make sense of our phenomenal world. And as to Kant's prerequisite test: "How are synthetic cognitions, a priori possible?" I refer only to my essay "Beyond Kant and Hegel (In Answer to the Question ...)" ... in "The Review of Metaphysics", March 2013. The premise advanced in the essay may be seen to be fully apparent in this science of metaphysics. (shrink)

This paper presents a direction for narrative ethics based on ethical ideas found in the works of Michel Foucault. Narrative ethics is understood here at the meta-level of cultural discourse to see how the moral subject is constituted by the discursive practices that structure the contemporary debate on reproductive technologies. At this level it becomes meta-narrative-ethics. After a theoretical discussion, this paper uses two literary narratives representing the polarized views in the debate to show how the moral subject may be (...) compelled to relate to its self. Ethics is redefined as Foucauldian rapport à soi, and ethical analysis, at this meta-level, shows how the moral self is intimately connected to cultural discourse. (shrink)

The idea of 'holiness' is central to religion, but it is also one of the hardest concepts to define. Is 'holiness' a synonym for Godliness, one of God's attributes, or does it have independent existence? What does it mean to say that both God and man are holy? What is the proper understanding of 'Be holy, because I the Lord your God am holy'? A Theology of Holiness analyzes the meaning of the Hebrew root k-d-sh from ancient sources, throughout Tanakh, (...) the Talmud, Rashi, Maimonides, Nachmanides, Rabbi Samson Raphael Hirsch, and Rabbi Joseph B. Soloveitchik. Ultimately, it is a work of theology, and helps the reader achieve a deeper understanding of holiness"--Page 4 of cover. (shrink)

Chapter One The Karaite Community of Jerusalem in the Tenth and Eleventh Centuries: Background and Development A time of intellectual change The eighth and ninth centuries were a time of great political and intellectual change for Jews ...

"In the second half of his life, Bertrand Russell transformed himself from a major philosopher, whose work was intelligible to a small elite, into a political activist and popular writer, know to millions throughout the world. Yet his life is the tragic story of a man who believed in a modern, rational approach to life and who, though his ideas guided popular opinion throughout the twentieth century, lost everything." "Drawing on thousands of documents collected at the Russell archives in Canada, (...) Monk steers through the turbulence of Russell's public activities, scrutinizing his sometimes paradoxical and often outrageous pronouncements. Monk's focus, however, is on the tragedy of Russell's personal life, and in revealing this inner drama Monk has relied heavily on the cooperation of Russell's surviving relatives and access to previously unexamined legal and private correspondence."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved. (shrink)

The Great Divide in metaphysical debates about laws of nature is between Humeans, who think that laws merely describe the distribution of matter, and non-Humeans, who think that laws govern it. The metaphysics can place demands on the proper formulations of physical theories. It is sometimes assumed that the governing view requires a fundamental / intrinsic direction of time: to govern, laws must be dynamical, producing later states of the world from earlier ones, in accord with the fundamental direction of (...) time in the universe. In this paper, we propose a minimal primitivism about laws of nature (MinP) according to which there is no such requirement. On our view, laws govern by constraining the physical possibilities. Our view captures the essence of the governing view without taking on extraneous commitments about the direction of time or dynamic production. Moreover, as a version of primitivism, our view requires no reduction / analysis of laws in terms of universals, powers, or dispositions. Our view accommodates several potential candidates for fundamental laws, including the principle of least action, the Past Hypothesis, the Einstein equation of general relativity, and even controversial examples found in the Wheeler-Feynman theory of electrodynamics and retrocausal theories of quantum mechanics. By understanding governing as constraining, non-Humeans who accept MinP have the same freedom to contemplate a wide variety of candidate fundamental laws as Humeans do. (shrink)

The second volume of Ray Monk's biography of Bertrand Russell focuses on Russell's tragic and moving relationship with his first son John. It uses the relationship as a centerpoint to expound on Russell's public achievements, such as his political campaigning for peace.

Bohmian mechanics and the Ghirardi-Rimini-Weber theory provide opposite resolutions of the quantum measurement problem: the former postulates additional variables (the particle positions) besides the wave function, whereas the latter implements spontaneous collapses of the wave function by a nonlinear and stochastic modification of Schrödinger's equation. Still, both theories, when understood appropriately, share the following structure: They are ultimately not about wave functions but about 'matter' moving in space, represented by either particle trajectories, fields on space-time, or a discrete set of (...) space-time points. The role of the wave function then is to govern the motion of the matter. (shrink)

Book Information Nature's Purposes: Analyses of Function and Design in Biology. Edited by Allen Colin, Bekoff Mark and Lauder George. MIT Press. Cambridge. 1998. Pp. vi + 597. Paperback, US$31.50.

In pediatric emergency rooms (ERs), social workers must navigate diverse responsibilities including acting as advocates and liaisons between families and multidisciplinary treatment teams, providing compassionate support to families in crisis, and assessing for and reporting any suspicions of child abuse or neglect. These potentially contrasting roles can place social workers at the center of dealing with ethical dilemmas and advocating against ethical violations, such as bias and discrimination toward families. This qualitative study seeks to gain insight into ethical issues commonly (...) encountered in pediatric ERs by exploring the perspectives of 23 social workers at Level 1 trauma centers in the United States. Thematic analysis was used to develop major themes and subthemes related to ethical violations, dilemmas, and best practices in pediatric ERs. Major themes emerged related to unfair treatment of families (with subthemes of bias, discrimination, and compassion fatigue), ethical dilemmas (with subthemes of cultural issues, safety and system issues), and promoting ethical practices (with subthemes of self-awareness, advocacy, and efforts to change the system). This study provides important insights into ethical issues in pediatric ERs as experienced by social workers and can inform efforts to improve the quality and equity of care for all families in pediatric ERs. (shrink)

Ludwig Wittgenstein is perhaps the greatest philosopher of the twentieth century, and certainly one of the most original in the entire Western tradition. Given the inaccessibility of his work, it is remarkable that he has inspired poems, paintings, films, musical compositions, titles of books -- and even novels. In his splendid biography, Ray Monk has made this very compelling human being come alive in a way that perfectly explains the fascination he has evoked. Wittgenstein's life was one of great moral (...) and spiritual depth. Although his work addresses problems of logic, language, mind, and knowledge, he often described it as having an ethical point, and once said that he "could not help seeing every problem from a religious point of view." In successfully bridging the gap assumed by many to exist between Wittgenstein's life and his work, Monk's biography helps to explain the interest in Wittgenstein's later philosophy on the part of Buddhist scholars. (shrink)

The purpose of this article is to discuss an external whistleblowing event that occurred after all internal whistleblowing through the hierarchy of the organization had failed. It is argued that an organization that does not support those that whistle blow because of violation of professional standards is indicative of a failure of organizational ethics. Several ways to build an ethics infrastructure that could reduce the need to resort to external whistleblowing are discussed. A relational ethics approach is presented as a (...) way to eliminate the negative consequences of whistleblowing by fostering an interdependent moral community to address ethical concerns. (shrink)

Examining one of the fundamental issues in cognitive psychology: How does our conscious experience come to be the way it is?

Where much contemporary philosophy seeks to stave off the "threat" of nihilism by safeguarding the experience of meaning--characterized as the defining feature of human existence--from the Enlightenment logic of disenchantment, this book attempts to push nihilism to its ultimate conclusion by forging a link between revisionary naturalism in Anglo-American philosophy and anti-phenomenological realism in recent French philosophy. Contrary to an emerging "post-analytic" consensus which would bridge the analytic-continental divide by uniting Heidegger and Wittgenstein against the twin perils of scientism and (...) skepticism, this book short-circuits both traditions by plugging eliminative materialism directly into speculative realism. (shrink)

“What is it that agitates you, my dear Victor? What is it you fear?” -/- “The monster now becomes more vengeful. He murders Victor’s friend Henry Clerval and his wife Elizabeth on the night of her wedding to Victor, and Victor sets out in pursuit of the friend across the icy Artic regions. The monster is always ahead of him, leaving tell tale marks behind and tantalizing his creator. Victor meets with his death in the pursuit of the monster he (...) had created with a noble objective.” [ http://philpapers.org/profile/112741] . (shrink)

Evolutionary scepticism holds that the evolutionary account of the origins of the human cognitive apparatus has sceptical implications for at least some of our beliefs. A common target of evolutionary scepticism is moral realism. Scientific realism, on the other hand, is much less frequently targeted, though the idea that evolutionary theory should make us distrustful of science is by no means absent from the literature. This line of thought has received unduly little attention. I propose to remedy this by advancing (...) what I will call an evolutionary sceptical challenge to scientific realism. I argue that, given standard evolutionary theory, our possession of sound innate metaphysical intuitions would have taken an epistemically problematic ‘lucky accident’. This, as I will show, entails that scientific realism is a self-undermining position. I discuss objections to my argument’s two premises, including ones that appeal to the success of the sciences and to the possibility that sound innate metaphysical intuitions evolved as an evolutionary ‘by-product’. I then draw out an advantage of my argument over a similar one recently put forward by Graber and Golemon. I finish by submitting that scientific realism, given the soundness of my argument, is faced with a new ‘Darwinian Dilemma’, and briefly address the significance of this for the debate between realists and anti-realists in the philosophy of science. (shrink)

Religion, science, and naturalism -- Perception and religious experience -- Panexperientialism, freedom, and the mind-body relation -- Naturalistic, dipolar theism -- Natural theology based on naturalistic theism -- Evolution, evil, and eschatology -- The two ultimates and the religions -- Religion, morality, and civilization -- Religious language and truth -- Religious knowledge and common sense.

Schrödinger’s first proposal for the interpretation of quantum mechanics was based on a postulate relating the wave function on configuration space to charge density in physical space. Schrödinger apparently later thought that his proposal was empirically wrong. We argue here that this is not the case, at least for a very similar proposal with charge density replaced by mass density. We argue that when analyzed carefully, this theory is seen to be an empirically adequate many-worlds theory and not an empirically (...) inadequate theory describing a single world. Moreover, this formulation—Schrödinger’s first quantum theory—can be regarded as a formulation of the many-worlds view of quantum mechanics that is ontologically clearer than Everett’s. (shrink)

Formal models of appearance and reality have proved fruitful for investigating structural properties of perceptual knowledge. This paper applies the same approach to epistemic justification. Our central goal is to give a simple account of The Preface, in which justified belief fails to agglomerate. Following recent work by a number of authors, we understand knowledge in terms of normality. An agent knows p iff p is true throughout all relevant normal worlds. To model The Preface, we appeal to the normality (...) of error. Sometimes, it is more normal for reality and appearance to diverge than to match. We show that this simple idea has dramatic consequences for the theory of knowledge and justification. Among other things, we argue that a proper treatment of The Preface requires a departure from the internalist idea that epistemic justification supervenes on the appearances and the widespread idea that one knows most when free from error. (shrink)

This paper focuses on the issue of what to do if a couple who generates embryos chooses to lawfully, and in their (and my) view, ethnically discard those embryos. Specifically, is it appropriate to use the cells that come from “excess” embryos in medical research instead of discarding them when a couple has ceased trying to have any additional children?

A major disagreement between different views about the foundations of quantum mechanics concerns whether for a theory to be intelligible as a fundamental physical theory it must involve a ‘primitive ontology’ (PO), i.e. variables describing the distribution of matter in four-dimensional space–time. In this article, we illustrate the value of having a PO. We do so by focusing on the role that the PO plays for extracting predictions from a given theory and discuss valid and invalid derivations of predictions. To (...) this end, we investigate a number of examples based on toy models built from the elements of familiar interpretations of quantum theory. (shrink)

This paper develops a question-sensitive theory of intention. We show that this theory explains some puzzling closure properties of intention. In particular, it can be used to explain why one is rationally required to intend the means to one’s ends, even though one is not rationally required to intend all the foreseen consequences of one’s intended actions. It also explains why rational intention is not always closed under logical implication, and why one can only intend outcomes that one believes to (...) be under one’s control. (shrink)

Already hailed as a masterpiece, Foundations of Language offers a brilliant overhaul of the last thirty-five years of research in generative linguistics and related fields. "Few books really deserve the cliché 'this should be read by every researcher in the field'," writes Steven Pinker, author of The Language Instinct, "but Ray Jackendoff's Foundations of Language does." Foundations of Language offers a radically new understanding of how language, the brain, and perception intermesh. The book renews the promise of early generative linguistics: (...) that language can be a valuable entrée into understanding the human mind and brain. The approach is remarkably interdisciplinary. Behind its innovations is Jackendoff's fundamental proposal that the creativity of language derives from multiple parallel generative systems linked by interface components. This shift in basic architecture makes possible a radical reconception of mental grammar and how it is learned. As a consequence, Jackendoff is able to reintegrate linguistics with philosophy of mind, cognitive and developmental psychology, evolutionary biology, neuroscience, and computational linguistics. Among the major topics treated are language processing, the relation of language to perception, the innateness of language, and the evolution of the language capacity, as well as more standard issues in linguistic theory such as the roles of syntax and the lexicon. In addition, Jackendoff offers a sophisticated theory of semantics that incorporates insights from philosophy of language, logic and formal semantics, lexical semantics of various stripes, cognitive grammar, psycholinguistic and neurolinguistic approaches, and the author's own conceptual semantics. (shrink)

(2013). Conversational implicature, communicative intentions, and content. Canadian Journal of Philosophy: Vol. 43, Essays on the Nature of Propositions, pp. 720-740.

The answer given to 'the problem of evil' in the Bible that apologists, theologians, and philosophers have not recognized or understood, having sought for answers to the problem outside the sacred texts wherein alone the unequivoval answer can be found, if only one puts together the relevant texts, as for instance, the book of Job, the book of Isaiah concerning prophecies related to the return of Christ, the book of Ezekiel, the 24th chapter of Matthew, certain passages from the letters (...) of Paul, and the book of Reveation. The central theme in this work is that evil exists now not by reason of God's presence, but by reason of God's absence. We have been left to our own devices. The reason for this is very clear in these texts, and the work spells this out in no uncertain terms, and once this reason is made fully apparent, and undeniable, it will leave no viable excuse for anyone to reject the return of the King of kings, and His eternal rule over all as the Prince of peace. (shrink)

First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

For the Intentionalist, utterance content is wholly determined by a speaker’s meaning-intentions; the sentence uttered serves merely to facilitate the audience’s recovering these intentions. We argue that Intentionalists ought to be Particularists, holding that the only “principles” of meaning recovery needed are those governing inferences to the best explanation; “principles” that are both defeasible and, in a sense to be elaborated, variable. We discuss some ways in which some theorists have erred in trying to tame the “wild west” of pragmatics (...) and context-sensitivity -- including recent work that makes essential appeal to the information structure of a discourse -- and in so doing, offer a general recipe for defending the Particularist picture of utterance content and its recovery that we favor. (shrink)

According to proponents of the face-value account, a beliefreport of the form ‘S believes that p’ is true just in case the agentbelieves a proposition referred to by the that-clause. As againstthis familiar view, I argue that there are cases of true beliefreports of the relevant form in which there is no proposition that thethat-clause, or the speaker using the that-clause, can plausibly betaken as referring to. Moreover, I argue that given the distinctiveway in which the face-value theory of belief-reports (...) fails, there ispressure to give up the metaphysical thesis that belief is apropositional attitude. I conclude by suggesting that we allownon-propositional entities to be amongst the relata of thebelief-relation, and make some speculative remarks concerning whatsuch entities might be like. (shrink)