Delicately and with a voluptuous spiral movement the leaf from the tall beech tree detached itself from its branch and landed on the flaming bed made by its companions.That autumn, that morning, while I was observing this unique event, I began to reflect on the emotion I felt in its probably universal connotation. Like aesthetic feeling, a great many concepts affect living beings in the deepest part of themselves, and come from the depths of the cognitive processes, those determinants that (...) are innate dispositions to feel and know. Those depths have a reality and a meta-historical, infra- and extra-verbal dimension. (shrink)

In this article I argue that if conscience, working properly, involves some form of ‘moral tug’, then this is incompatible with the state of ‘quiescence’ put forward as a central element of Eleonore Stump’s account of repentance. Quiescence is also a key notion for Stump’s theodicy in Wandering in the Darkness and Stump’s thesis in her book, Atonement. Quiescence is about an inactive, or neutral, or stationary, state of the will prior to turning to the good, or (...) God, through receiving God’s saving grace. But if God exerts a non–coercive pressure on people through their conscience to turn to him, and turn from evil, then this drawing towards the good, or tugging away from evil, can only be yielded to, or resisted. There is no neutral state. I give examples of language such as being ‘bound’ to obey one’s conscience, which seem to reflect such non–coercive pressure. I conclude by commenting on free will. (shrink)

Allen Carlson has argued that a science-based model of appreciation is most appropriate in the aesthetic appreciation of nature. While I find his model of appreciation coherent and valuable, I reject his argument that this model ought to be preferred to others, such as an emotion-based or a formalist model of appreciation. Carlson's rejection of these other models is exclusionary and runs counter to pragmatist ideals. I argue for an alternative model, one which accommodates both cognitive and noncognitive models of (...) appreciation, which I call the aesthetic-attention model of appreciation. (shrink)

Stump and Timpe have recently proposed Thomistic based solutions to the traditional problem in Christian theology of how to relate grace and free will. By taking a closer look at the notion of control, I subject Timpe’s account – itself an extension of Stump’s account – to extended critique. I argue that the centrepiece of Timpe’s solution, his reliance on Dowe’s notion of quasi-causation, is misguided and irrelevant to the problem. As a result, Timpe’s account fails to avoid Semi-Pelagianism. I (...) canvass two alternatives, each of which adheres to the broad theological assumptions made by Stump and Timpe, including the positing of only one “unique” grace. I conclude that each of these proposals fails, although I argue that one comes as close as it is possible to get to a solution given the assumptions made. -/- . (shrink)

I call the Particular Problem of Hell the problem of explaining why God allows a certain set of created persons to populate hell, as opposed to allowing some other set of created persons to do so. This paper proposes a solution to PPH on behalf of proponents of Divine Universal Causality — the view, roughly, that God causes everything distinct from himself to exist at any time it exists. Despite initial appearances, I argue, proponents of DUC can adopt a version (...) of the popular approach to the Problem of Hell sometimes called the Choice Model. My proposal is based upon Eleonore Stump's Thomistically-inspired notion that our wills can enter a state of "quiescence" with respect to a given option. While proponents of DUC will, I argue, most likely find Stump's own quiescence-based solution to PPH unacceptable, there is a way of modifying her approach that renders it compatible with God's causing everything distinct from himself, including the free choices of his creatures. (shrink)

Several recent incompatibilist accounts of divine grace and human free will have appealed to the notion of quiescence in an attempt to avoid semi-Pelagianism while retaining the fallen person’s control over coming to faith and thus the agent’s responsibility for failing to come to faith. In this essay I identify three distinct roles that quiescence has been employed to play in the recent literature. I outline how an account of divine grace and human free will may employ (...) class='Hi'>quiescence to play one role without playing either of the others. I also note that getting clear about these roles allows us to see that so-called sourcehood accounts of free will do not need to appeal to quiescence to avoid semi-Pelagianism. Far from being a benefit of sourcehood accounts, however, this highlights a serious defect in such accounts; I draw out this defect, developing it into a general argument against sourcehood accounts of free will. (shrink)

Cellular mechanisms whereby quiescent stem cells sense tissue injury and transition to an activated state are largely unknown. Quiescent skeletal muscle stem cells (MuSCs, also called satellite cells) have elaborate, heterogeneous projections that rapidly retract in response to muscle injury. They may therefore act as direct sensors of their niche environment. Retraction is driven by a Rac‐to‐Rho GTPase activity switch that promotes downstream MuSC activation events. These and other observations lead to several hypotheses: (1) projections are morphologically dynamic at (...) class='Hi'>quiescence, providing a surveillance function for muscle damage; (2) quiescent projection dynamics are regulated by the relative balance of Rac and Rho activities promoted by niche‐derived cues; (3) projections, particularly their associated filopodia, sense tissue damage via changes to the biomechanical properties of the niche and/or detection of signaling cues released by damaged myofibers; and (4) the dynamic nature of projections results in a population of MuSCs with heterogeneous functional properties. These concepts may extend to other types of quiescent stem cells, as well as prove useful in translational research settings. (shrink)

spirit of Quiescence, the spirit of Unrest; the spirit of Immobility, the spirit of Change; the spirit of Hold-fast-to-that-which-you-have, the spirit of Let-go-and-fly-to-that-which-youhave-not; the spirit of the slow and steady builder, careful of its labors, loath to part with any of its achievements, wishful to keep, and unable to discriminate between what is worth keeping and what is better cast aside, and the spirit of the inspirational destroyer, fertile in creative fancies, volatile, careless in its luxuriance of effort, inclined (...) to cast away the good together with the bad. (shrink)

The somatic mutation theory (SMT) of cancer has been and remains the prevalent theory attempting to explain how neoplasms arise and progress. This theory proposes that cancer is a clonal, cell‐based disease, and implicitly assumes that quiescence is the default state of cells in multicellular organisms. The SMT has not been rigorously tested, and several lines of evidence raise questions that are not addressed by this theory. Herein, we propose experimental strategies that may validate the SMT. We also call (...) attention to an alternative theory of carcinogenesis, the tissue organization field theory (TOFT), which posits that cancer is a tissue‐based disease and that proliferation is the default state of all cells. Based on epistemological and experimental evidence, we argue that the TOFT compellingly explains carcinogenesis, while placing it within an evolutionarily relevant context.magnified imagemagnified imageAna Soto and Carlos Sonnenschein are at Tufts University School of Medicine, Boston, MA, USA. (shrink)

The somatic mutation theory has been the prevailing paradigm in cancer research for the last 50 years. Its premises are: (1) cancer is derived from a single somatic cell that has accumulated multiple DNA mutations, (2) the default state of cell proliferation in metazoa is quiescence, and (3) cancer is a disease of cell proliferation caused by mutations in genes that control proliferation and the cell cycle. From this compelling simplicity, an increasingly complicated picture has emerged as more than (...) 100 oncogenes and 30 tumor suppressor genes have been identified. To accommodate this complexity, additional ad hoc explanations have been postulated. After a critical review of the data gathered from this perspective, an alternative research program has been proposed. It is based on the tissue organization field theory, the premises of which are that carcinogenesis represents a problem of tissue organization, comparable to organogenesis, and that proliferation is the default state of all cells. The merits of these competing theories are evaluated herein. BioEssays 26:1097–1107, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Various captivity-related health problems have been described as arising in the farming of sea turtles at the Cayman Turtle Farm (CTF). Our study included a desktop review of turtle farming, direct onsite inspection at the CTF, assessment of visual materials and reports provided by investigators from the World Society for the Protection of Animals (WSPA), and a limited analysis of water quality for potential pathogens. In particular, we assessed physical and behavioural condition of animals for signs of stress, injury and (...) disease. During the onsite inspection we identified three distinct signs of physical injury and disease, six distinct signs of abnormal and problematic arousal- and discomfort-related behaviour; and three distinct signs of normal quiescence- and comfort-related behaviour. On evaluation of evidence provided by the WSPA we identified ten distinct signs of physical injury and disease, and management- or genetic-related conditions; six distinct signs of abnormal and problematic arousal- and discomfort-related behaviour; and three distinct signs of normal quiescence- and comfort-related behaviour. We conclude that sea turtles at the CTF manifested important physical and behavioural signs that are indicative of problematic management and captivity-related stress, and the limitations of sea turtle adaptive plasticity in captivity. The problematic physical and behavioural signs, in our view, related to the inherent nature of intensive turtle propagation which in particular involves overt- and crypto-overcrowding and understimulating environments, and an associated failure to meet all the physical, biological and innate behavioural needs of sea turtles. (shrink)

Several philosophers and theologians have attempted to formulate monergistic, soft libertarian accounts of salvation. These accounts hold that the sinner has the ability to either resist or to do nothing at all with God’s universally given saving grace, in which latter case God will save her. However, I wonder with Cyr and Flummer whether these accounts go far enough because the nonresistant sinner voluntarily remains quiescent and is therefore arguably praiseworthy. I aim to remedy this alleged weakness by formulating a (...) possible account on which it never crosses the nonresistant sinner’s mind to resist, making her quiescence an involuntary omission. For all sinners whose minds it crosses to resist, they, on the proposed account, freely choose to resist. Combining Molinism with the scriptural notion of blaspheming against the Holy Spirit, I proceed to explain why it may cross the mind of some sinners and not others to resist. (shrink)

Eleonore Stump has recently articulated an account of grace which is neither deterministic nor Pelagian. Drawing on resources from Aquinas’s moral psychology, Stump’s account of grace affords the quiescence of the will a significant role in an individual’s coming to saving faith. In the present paper, I firstoutline Stump’s account and then raise a worry for that account. I conclude by suggesting a metaphysic that provides a way of resolving this worry. The resulting view allows one to maintain both (...) (i) that divine grace is the efficient cause of saving faith and (ii) that humans control whether or not they come to saving faith. (shrink)

The germ lineage has been studied for a long time because of its crucial role in the propagation and survival of a species. While this lineage, in contrast to the soma, is clearly unique in its totipotent ability to produce a new organism, it has now been found also to have specific features at the cellular level. One feature, a period of transcriptional quiescence in the early germ cell precursors, has been observed in both Drosophila and C. elegans, where (...) it is essential for the formation and the survival of the germline. In addition, there are numerous instances where these early germ cells are reliant on translational regulation, especially in Drosophila. The genes that are important for these two functions, the mechanisms of their action, and studies in vertebrate organisms that reveal similarities as well as some potential differences in early germ cell development are discussed. BioEssays 25:326–335, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

This article offers certain criticisms of some of the main arguments and suggestions put forward by G. A. Cohen in his 1980 Isaac Deutscher Memorial Lecture. As against Cohen I argue: (i) that it is strategically irrelevant for committed socialists or Marxists to argue that capitalism is unjust; (ii) that the political quiescence of the proletariat has less to do with its sense of justice or other ideological factors than with non?ideological factors such as its realization that the struggle (...) for Communism may not be worth it; (iii) that Communism is, anyway, impossible, and (iv) that the tension in Marx and Cohen between the view that capitalism is unjust and that capitalist exploitation is necessary for the productive progress required for the ?ultimate liberation of humanity? cannot be relieved. (shrink)

138 titles across a wide range of scholarly publications illustrate the conceptual affinities that connect the palaetiological sciences of biological systematics, historical linguistics, and stemmatics. These three fields all have as their central objective the reconstruction of evolutionary "trees of history" that depict phylogenetic patterns of descent with modification among species, languages, and manuscripts. All three fields flourished in the nineteenth century, underwent parallel periods of quiescence in the early twentieth century, and in recent decades have seen widespread parallel (...) revivals. "Tree thinking" (O'Hara, 1988) is now standard within evolutionary biology, and the unity of what William Whewell called palaetiology is being once again appreciated by scholars and scientists in many fields. (shrink)

Bone marrow is the main site for hematopoiesis in adults. It acts as a niche for hematopoietic stem cells (HSCs) and contains non‐hematopoietic cells that contribute to stem cell dormancy, quiescence, self‐renewal, and differentiation. HSC also exist in resting spleen of several species, although their contribution to hematopoiesis under steady‐state conditions is unknown. The spleen can however undergo extramedullary hematopoiesis (EMH) triggered by physiological stress or disease. With the loss of bone marrow niches in aging and disease, the spleen (...) as an alternative tissue site for hematopoiesis is an important consideration for future therapy, particularly during HSC transplantation. In terms of harnessing the spleen as a site for hematopoiesis, here the remarkable regenerative capacity of the spleen is considered with a view to forming additional or ectopic spleen tissue through cell engraftment. Studies in mice indicate the potential for such grafts to support the influx of hematopoietic cells leading to the development of normal spleen architecture. An important goal will be the formation of functional ectopic spleen tissue as an aid to hematopoietic recovery following clinical treatments that impact bone marrow. For example, expansion or replacement of niches could be considered where myeloablation ahead of HSC transplantation compromises treatment outcomes. (shrink)

Historical analysis and policy making often require counterfactual thought experiments that isolate hypothesized causes from a vast array of historical possibilities. However, a core precept of Jervis's “systems thinking” is that causes are so interconnected that the historian can only with great difficulty imagine causation by subtracting all variables but one. Prediction, according to Jervis, is even more problematic: The more sensitive an event is to initial conditions (e.g., butterfly effects), the harder it is to derive accurate forecasts. Nevertheless, if (...) awareness of system effects can help forecasters better calibrate their probability estimates of whether or not certain events will come to pass, systems thinkers who are pessimistic about prediction are diluting their confidence too much. The challenge is a meta-cognitive one: thinking systematically about when to engage in systems thinking; and weighing the costs and benefits of using simple or complex heuristics in policy environments that can shift suddenly from quiescence to turbulence. (shrink)

Review article on Eleonore Stump: Atonement, Oxford University Press, 2019.

The nature and time course of sleep onset (hypnagogic) mentation was studied in the home environment using the Nightcap, a reliable, cost-effective, and relatively noninvasive sleep monitor. The Nightcap, linked to a personal computer, reliably identified sleep onset according to changes in perceived sleepiness and the appearance of hypnagogic dream features. Awakenings were performed by the computer after 15 s to 5 min of sleep as defined by eyelid quiescence. Awakenings from longer periods of sleep were associated with (1) (...) an increase in reported sleepiness, (2) a decrease in the length of mentation reports, (3) a decrease in the frequency of reports of normal, wake-like thoughts, (4) an increase in the frequency of ''unusual thoughts,'' and (5) increased frequencies of formal dream features, including visual hallucination, self-representation, fictive movement, narrative plot, and bizarreness. While sleep-onset reports can include all features of rapid eye movement (REM) dream reports, the number of such features is markedly reduced at sleep onset, suggesting that this mentation is a greatly diminished version of REM dreaming. (shrink)

I investigate the intrinsic/extrinsic nature of stemness in muscle stem cells (MSC) by relying on recent research on quiescence, with the aim of shedding light on the nature of dispositions and deriving some consequences about stem cells. First, I argue why the study of quiescence is the best available way to establish any claim about the intrinsicness/extrinsicness of stemness at least is some stem cells. Drawing on that, I argue that MSC’s stem capacities result from the combination of (...) intrinsic cues plus extrinsic factors from the stem cell niche, making stemness an extrinsic disposition in MSC. Importantly, it is shown that the niche allows the instantiation of stemness in MSC by acting as a masker of its manifestation. This shows that stemness is, at least in MSC, what I call an extrinsically structurally masked disposition (SMD); that is, a disposition whose instantiation requires, as a condition of possibility, the interaction between the bearer and a masker. Finally, I conclude by suggesting some potential consequences of this observation for the philosophical study of dispositions and for stem cell research. (shrink)

The nature and time course of sleep onset mentation was studied in the home environment using the Nightcap, a reliable, cost-effective, and relatively noninvasive sleep monitor. The Nightcap, linked to a personal computer, reliably identified sleep onset according to changes in perceived sleepiness and the appearance of hypnagogic dream features. Awakenings were performed by the computer after 15 s to 5 min of sleep as defined by eyelid quiescence. Awakenings from longer periods of sleep were associated with an increase (...) in reported sleepiness, a decrease in the length of mentation reports, a decrease in the frequency of reports of normal, wake-like thoughts, an increase in the frequency of “unusual thoughts,” and increased frequencies of formal dream features, including visual hallucination, self-representation, fictive movement, narrative plot, and bizarreness. While sleep-onset reports can include all features of rapid eye movement dream reports, the number of such features is markedly reduced at sleep onset, suggesting that this mentation is a greatly diminished version of REM dreaming. (shrink)

Given certain anti-Pelagian assumptions he endorses, Aquinas faces an “arbitrariness problem” explaining why God predestines and reprobates the particular individuals he does. One response to the problem that Aquinas offers—biting the bullet and conceding God’s arbitrariness—has a high theoretical cost. Eleonore Stump proposes a less costly alternative solution on Thomas’s behalf, drawing on his notion that our wills may rest in a state of “quiescence.” Her proposal additionally purports to answer the general question why God reprobates anyone at all. (...) I argue that Aquinas’s understanding of the relationship between divine causation and human freedom prevents him from accepting Stump’s proposal as she herself puts it forward; he couldn’t accept it as an answer to the general question. Nevertheless, I claim, granted one controversial but widely accepted assumption—that he isn’t a divine determinist—Aquinas could accept a slightly modified version of her quiescence solution to the arbitrariness problem. Indeed, there is evidence that he did accept some of its key components. (shrink)

The relationships between oncogenes, cell‐cycle control genes, and growth‐related genes are described. An important generalization from the data is that all the oncogenes and cell‐cycle control genes so far characterized appear to be genes for growth factors or for receptors to growth factors, or to be involved in the general metabolism and structure of the cell. It is suggested that the transition in cell growth from quiescence to the proliferative state, in early G1, may be less specific than previously (...) thought and involve a general priming of the cells for more specific later stimuli. (shrink)

DREAM complexes are transcriptional regulators that control the expression of hundreds to thousands of target genes involved in the cell cycle, quiescence, differentiation, and apoptosis. These complexes contain many subunits that can vary according to the considered target genes. Depending on their composition and the nature of the partners they recruit, DREAM complexes control gene expression through diverse mechanisms, including chromatin remodeling, transcription cofactor and factor recruitment at various genomic binding sites. This complexity is particularly high in mammals. Since (...) the discovery of the first dREAM complex (drosophila Rb, E2F, and Myb) in Drosophila melanogaster, model organisms such as Caenorhabditis elegans, and plants allowed a deeper understanding of the processes regulated by DREAM‐like complexes. Here, we review the conservation of these complexes. We discuss the contribution of model organisms to the study of DREAM‐mediated transcriptional regulatory mechanisms and their relevance in characterizing novel activities of DREAM complexes. (shrink)

Jizang (549−623 CE), the key philosophical exponent of the Sanlun tradition of Chinese Buddhism, based his philosophy considerably on his reading of the works of Nāgārjuna (c.150−250 CE), the founder of the Indian Madhyamaka school. However, although Jizang sought to follow Nāgārjuna closely, there are salient features in his thought on language that are notably absent from Nāgārjuna’s works. In this paper, I present a philosophical analysis of Jizang’s views of the relationship between speech and silence and compare them with (...) those of Nāgārjuna. I first elaborate on Nāgārjuna’s doctrine of twofold truth and discuss his thought concerning the relationship between language and ineffable quiescence. I then examine Jizang’s interpretation of the doctrine. Thereafter, I distinguish silence qua teaching from silence qua principle and examine Jizang’s views on the relationship between speech and these two kinds of silence. It is shown that while Nāgārjuna leans toward affirming a clear-cut distinction between speech and the ineffable quiescence, Jizang endorses the nonduality of conventional speech and sacred silence. (shrink)

While the demise of Enron has raised a number of interesting issues, such as proper governance of large corporations, and the effectiveness and efficiency of statutory direction and regulatory mechanisms, the lack of meaningful vocal stakeholder stewardship has not been one of them. While the relative “silence” of Enron’s stakeholders (watchdogs) could simply have been a communication glitch, or a temporary lapse in social morality, an understanding of hat was not said and why, could well be a significant requisite in (...) formulating meaningful measures to preclude future Enrons. Why weren’t the watchdogs barking? Why had the stakeholder alert system shut down? Further, what are the implications for then and now of this quiescence? Since Enron’s demise many questions have been asked and answered about what went wrong. But little has been said about why the stakeholders failed to speak out by exercising their fiduciary responsibilities. This paper takes a closer look at the behavior of some key Enron stakeholders. (shrink)

This essay focuses on the theme of intersubjectivity, which is central to the entire Indo-Tibetan Buddhist tradition. It addresses the following five themes pertaining to Buddhist concepts of intersubjectivity: the Buddhist practice of the cultivation of meditative quiescence challenges the hypothesis that individual human consciousness emerges solely from the dynamic interrelation of self and other; the central Buddhist insight practice of the four applications of mindfulness is a means for gaining insight into the nature of oneself, others and the (...) relation between oneself and the rest of the world, which provides a basis for cultivating a deep sense of empathy; the Buddhist cultivation of the four immeasurables is expressly designed to arouse a rich sense of empathy with others; the meditative practice of dream yoga, which illuminates the dream-like nature of waking reality is shown to have deep implications regarding the nature of intersubjectivity; the theory and practice of Dzogchen, the 'great perfection' system of meditation, challenges the assertion of the existence of an inherently real, localized, ego-centred mind, as well as the dichotomy of objective space as opposed to perceptual space. (shrink)

The problems with grace and free will have prompted long-standing theological conflicts, chiefly revolving around certain disagreements over the nature of divine causality in respect to the free will's of creatures and His foreknowledge of free acts. Eleonore Stump offers a new interpretation of divine action on the will that holds God only acts by way of formal causality and that human cooperation with grace is only by way of "quiescence." I argue that this account lacks coherence in certain (...) important respects, especially in how human beings freely decide upon conversion - a process impossible on this model. I also argue that any model of divine causality cannot escape the dichotomy of holding a Molinist or a Banezian model of efficacious grace. In response, I offer a new interpretation of classical Thomist models of grace that preserves human freedom and divine sovereignty in grace. (shrink)

This chapter explores the question of Confucius as a sage of “profound greatness” who embodies the fullness of Dao in his being (xuansheng 玄聖). It also discusses briefly the development of Lunyu learning in early medieval China. Xuanxue is often translated as “neo‐Daoism”. The merit of this translation is that it points to a new hermeneutical engagement with tradition, with a sharp focus on the concept of Dao. The idea of Confucius as a sage of profound greatness, wonders, and mystery (...) opens up a rich space for intellectual development. Whereas suwang may be of particular value to understanding the Confucius of history, xuansheng brings the sage into the present, into the thick of philosophical debate about the source, direction, and end of human existence. Different views on whether the sage experiences emotions can be found already in the Zhuangzi. The Zhuangzi argues that all phenomena ultimately rest on stillness and quiescence. (shrink)

Section I argues, against Peter Mew, that, since people create nothing ex nihilo, everything now privately owned incorporates something that once was not, and that this has important consequences for distributive justice. Section II defends the ?diachronic? approach to distributive justice against Mew's charge that it is ?otiose?, and section III claims that beliefs about distributive justice have a big effect on political conflict in the real world. Section IV enters a few disagreements with Mew's account of the political ? (...) class='Hi'>quiescence? of the Western proletariat. Section V relieves the tension between the Marxist commitment to the advancement of productive power and the Marxist commitment to those at whose expense that advancement occurs. (shrink)

The authors regard opiates as the primary neural substrate for social attachment, and peptide hormones as subsidiary. One may instead conclude from their evidence that oxytocin, vasopressin, and opiates play complementary roles in attachment. Oxytocin and vasopressin relate to different aspects of emotional experience, and opiates to quiescence from long-term attachment. This is related to intimacy versus affiliation.

Why does lust demand beauty? How does it differ from functional beauty and from the beauty of what is purposive without definable purpose? Does eroticism really aim at visions of immortality ? How does erotic craving differ from the cognitive or practical intentions that aim at objects or objectives ? What is the difference between sexual satisfaction and the erotic transport ? Is erotic passion really a craving for the quiescence of the inert? What is erotic glamour in women (...) and in men ? What kind of animality does eroticism see and crave in human bodies? Why is it youth that inflames the extreme emotions of eroticism ? (shrink)

The legal treatment of physician-assisted suicide is in flux. Reform has been impelled by several forces, including the recent success of novel constitutional arguments in the Ninth and Second Circuit Courts of Appeals. I will review and discuss Compassion in Dying v. State of Washington and Quill v. Vacco, addressing the constitutional arguments, and then briefly considering the attractions and difficulties of these new constitutional theories.Before 1990, state criminal laws dealing with assisted suicide had reached a remarkably stable consensus: suicide (...) was not illegal, but assisting suicide was a criminal action with no distinction typically made between physicians and others who assisted. The details of the relevant criminal law varied from state to state. Some states had criminal statutes specifically addressing assisted suicide, while others treated the practice under more general homicide statutes. But in no state was it clearly legal for a physician to prescribe a lethal medication at the request of a dying patient. While remarkable legal developments took place during the 1970s and 1980s regarding other aspects of the rights of dying patients, there was relative quiescence regarding the law of PAS. (shrink)

The legal treatment of physician-assisted suicide is in flux. Reform has been impelled by several forces, including the recent success of novel constitutional arguments in the Ninth and Second Circuit Courts of Appeals. I will review and discuss Compassion in Dying v. State of Washington and Quill v. Vacco, addressing the constitutional arguments, and then briefly considering the attractions and difficulties of these new constitutional theories.Before 1990, state criminal laws dealing with assisted suicide had reached a remarkably stable consensus: suicide (...) was not illegal, but assisting suicide was a criminal action with no distinction typically made between physicians and others who assisted. The details of the relevant criminal law varied from state to state. Some states had criminal statutes specifically addressing assisted suicide, while others treated the practice under more general homicide statutes. But in no state was it clearly legal for a physician to prescribe a lethal medication at the request of a dying patient. While remarkable legal developments took place during the 1970s and 1980s regarding other aspects of the rights of dying patients, there was relative quiescence regarding the law of PAS. (shrink)

During the 1980's and the early 1990's South Africa experienced disturbing political violence of an unprecedented scope, intensity and nature. It was disturbing because it entailed acts of horrifying brutality, notably the ‘necklace' and the massacre, all of this against the background of ‘civilized' and measured com promise and negotiation. It stubbornly continued despite the unbanning of the liberation political organisations, and the holding of ‘free and fair' elections in April 1994. And it was unprecedented in a whole range of (...) ways, but mainly because of the fact that it was intracommunal, or black- on- black, violence. It was the first time that Black political organisations had turned on each other rather than their white oppressors. For our purposes, what is interesting is the range of responses emanating from South African social scientists in explaining this new phenomenon. Historically, explaining Black political violence in South Africa has had a difficult time of it. Starting with Pierre van den Berghe in 1962, predictions of imminent revolution against the apartheid regime have been so regularly and frequently proved wrong, that a whole industry has arisen in explaining quiescence rather than violence. The first cluster of theories spawned by the 1976 schools uprising, as Frank Molteno noted in his 1979 review, were analytically disappointing, if not crudely racist. Subsequent overviews by Manganyi & du Toit in 1990, and Beinart in 1992 have born evidence of considerably greater sophistication.; Manganyi, N & A du Toit, ; Beinart, W ). Nevertheless, as I shall show, most have remained within quite conventional theoretical and structuralist parameters. Many have their roots in the earlier dominant Marxism of the 1970's. In this sense they tend towards structural and class determinism, towards absolutist notions of power, and absolutist moral judgement of both apartheid and the individuals associated, however indirectly, with it. In consequence, Black incumbents of apartheid structures were inevitably depicted as willess and powerless puppets dancing to the tune of omnipotent White masters. In this context, it was wrong to talk of black- on- black violence, since one side of this equation, in reality, represented white interests. Much of this analysis also started from quite easy notions of the origins of violence. In this view it was sufficient to show conflicts of interest, or contra diction, in order to conclude that violence had been adequately explained. Against this background the more hermeneutic contribution by André du Toit to the debate stands out as theoretically innovative, nuanced and bold. This is not to say that it is with out problems. But I do wish to present a picture of a social theorist of considerable imagination and subtletly. Looking back over these theories, it would be tempting to say that the first category of structuralist accounts, should be supplemented with the second category of hermeneutic, accounts. But simply adding theoretically discrepant accounts together is too easy. It is only when the whole notion of structure, employed in the first category, is rethought in post-structuralist form, that an integration of the two elements becomes feasible. This paper follows a Giddensian line in pursuing this reconceptualization. (shrink)

During the 1980's and the early 1990's South Africa experienced disturbing political violence of an unprecedented scope, intensity and nature. It was disturbing because it entailed acts of horrifying brutality, notably the ‘necklace' and the massacre, all of this against the background of ‘civilized' and measured com promise and negotiation. It stubbornly continued despite the unbanning of the liberation political organisations, and the holding of ‘free and fair' elections in April 1994. And it was unprecedented in a whole range of (...) ways, but mainly because of the fact that it was intracommunal, or black- on- black, violence. It was the first time that Black political organisations had turned on each other rather than their white oppressors. For our purposes, what is interesting is the range of responses emanating from South African social scientists in explaining this new phenomenon. Historically, explaining Black political violence in South Africa has had a difficult time of it. Starting with Pierre van den Berghe in 1962, predictions of imminent revolution against the apartheid regime have been so regularly and frequently proved wrong, that a whole industry has arisen in explaining quiescence rather than violence (P. van den Berghe, 1965). The first cluster of theories spawned by the 1976 schools uprising, as Frank Molteno noted in his 1979 review, were analytically disappointing, if not crudely racist. Subsequent overviews by Manganyi & du Toit in 1990, and Beinart in 1992 have born evidence of considerably greater sophistication (Molteno, F (1979).; Manganyi, N & A du Toit, (1990); Beinart, W (1992)). Nevertheless, as I shall show, most have remained within quite conventional theoretical and structuralist parameters. Many have their roots in the earlier dominant Marxism of the 1970's. In this sense they tend towards structural and class determinism, towards absolutist notions of power, and absolutist moral judgement of both apartheid and the individuals associated, however indirectly, with it. In consequence, Black incumbents of apartheid structures were inevitably depicted as willess and powerless puppets dancing to the tune of omnipotent White masters. In this context, it was wrong to talk of black- on- black violence, since one side of this equation, in reality, represented white interests. Much of this analysis also started from quite easy notions of the origins of violence. In this view it was sufficient to show (objective) conflicts of interest, or contra diction, in order to conclude that violence had been adequately explained. Against this background the more hermeneutic contribution by André du Toit to the debate stands out as theoretically innovative, nuanced and bold. This is not to say that it is with out problems. But I do wish to present a picture of a social theorist of considerable imagination and subtletly. Looking back over these theories, it would be tempting to say that the first category of structuralist accounts, should be supplemented with the second category of hermeneutic, accounts. But simply adding theoretically discrepant accounts together is too easy. It is only when the whole notion of structure, employed in the first category, is rethought in post-structuralist form, that an integration of the two elements becomes feasible. This paper follows a Giddensian line in pursuing this reconceptualization. S. Afr. J. Philos. Vol.20(1) 2001: 102-123. (shrink)

Quietists aim to bring something to rest, to move it from activity to quiescence. This essay depicts and advocates a quietism of political interest, which is to say a divorce of political action from interest in the outcome of such action. Its principal interlocutor is Pascal, whose 1657 letter to Périer argues, on theological and epistemological grounds, for exactly such a separation. The essay argues that a quietism of political interest has several advantages over ordinary consequentialist political advocacy and (...) action, the most important among which is that the former can acknowledge that in a complex political system we are ordinarily unable to predict the results of enacting what we advocate, while the latter must occlude that fact. Quietists of political interest must replace concern with outcome by something else as a motive or cause for political advocacy and action; and while there are many possibilities here, in the West the only lively form of such quietism has been Christian-theological, in which political advocacy and action are, ideal-typically and sometimes actually, undertaken under the threefold assumption that: (1) advocacy of a political proposal assumes that justice in the political sphere is not attainable but must nonetheless be sought; (2) advocacy of a political proposal assumes that while Christian advocates can act unjustly, they cannot suffer injustice; and (3) advocacy of a political proposal proceeds always without concern for the outcome. (shrink)

The Buddhist and Daoist influences on the origins of the Taijitu and their influences on T’oegye’s philosophy are discussed. The notion of ji (tranquillity) is taken as an example on which the Neo-Confucianism debate and the limits of verbal representations are shown. T'oegye adherence to Zhu Xi in relying to the doctrine of mindfulness is taken into consideration as one of the central ones in the Ten diagrams, in contrast to Zhou Dunyi's emphasis on tranquillity. He followed the Zhu Xi's (...) line in a direction of commenting the commentaries or a form. He strongly relayed on words, although as a supplement to the diagrams. By this hediminished the force of the cartography of spirit so central in Chinese Song Neo-Confucianism. In T’oegye is not calm and tranquillity per se, but a conscious and wakeful state of absolute mental quiescence - one of the polar conditions of consciousness. (shrink)

Newborn neurons are generated in the adult hippocampus from a pool of self‐renewing stem cells located in the subgranular zone (SGZ) of the dentate gyrus. Their activation, proliferation, and maturation depend on a host of environmental and cellular factors but, until recently, the contribution of local neuronal circuitry to this process was relatively unknown. In their recent publication, Song and colleagues have uncovered a novel circuit‐based mechanism by which release of the neurotransmitter, γ‐aminobutyric acid (GABA), from parvalbumin‐expressing (PV) interneurons, can (...) hold radial glia‐like (RGL) stem cells of the adult SGZ in a quiescent state. This tonic GABAergic signal, dependent upon the activation of γ2 subunit‐containing GABAA receptors of RGL stem cells, can thus prevent their proliferation and subsequent maturation or return them to quiescence if previously activated. PV interneurons are thus capable of suppressing neurogenesis during periods of high network activity and facilitating neurogenesis when network activity is low. (shrink)

This essay focuses on the theme of intersubjectivity, which is central to the entire Indo-Tibetan Buddhist tradition. It addresses the following five themes pertaining to Buddhist concepts of intersubjectivity: the Buddhist practice of the cultivation of meditative quiescence challenges the hypothesis that individual human consciousness emerges solely from the dynamic interrelation of self and other; the central Buddhist insight practice of the four applications of mindfulness is a means for gaining insight into the nature of oneself, others and the (...) relation between oneself and the rest of the world, which provides a basis for cultivating a deep sense of empathy; the Buddhist cultivation of the four immeasurables is expressly designed to arouse a rich sense of empathy with others; the meditative practice of dream yoga, which illuminates the dream-like nature of waking reality is shown to have deep implications regarding the nature of intersubjectivity; the theory and practice of Dzogchen, the 'great perfection' system of meditation, challenges the assertion of the existence of an inherently real, localized, ego-centred mind, as well as the dichotomy of objective space as opposed to perceptual space. (shrink)

It is widely accepted that there exists a “resting” or “quiescent” state where a growing cell leaves the cell cycle to enter what is often called the “G0‐phase.” I propose that there is no biological reality to the “G0‐phase.” The experimental basis for proposing a G0‐phase is re‐examined and re‐analyzed here showing that the G0‐phase is an anthropomorphic construct with no biological reality.