« La vie s’est transformée en une suite intemporelle de chocs », écrivait Adorno, dans ses Minima Moralia, pour décrire l’expérience du front lors de la Seconde Guerre mondiale. À partir de la notion de choc, qui ponctue l’ensemble de l’oeuvre d’Adorno, se dégage en fait une problématique plus générale d’une crise de l’expérience moderne. En mettant en évidence certains parallèles entre les thèmes de la philosophie d’Adorno et la théorie psychanalytique du choc traumatique, j’entends cerner avec plus de précision (...) la teneur de la crise dont il est question, ses conséquences, ainsi que les possibilités qu’entrevoit le philosophe pour y mettre un terme.Reflecting upon the experience of the battle line during the Second World War, Adorno claimed that “life has changed into a timeless succession of shocks”. From this concept of shock, which punctuates the whole of Adorno’s work, emerges the more general problem of the crisis of modern experience. By drawing parallels between aspects of Adorno’s philosophy and of the psychoanalytic theory of traumatic shock, I intend to define more precisely the content of this crisis, its consequences, and the possibilities for its resolution glimpsed by the philosopher. (shrink)

Ritualized behavior, intuitively recognizable by its stereotypy, rigidity, repetition, and apparent lack of rational motivation, is found in a variety of life conditions, customs, and everyday practices: in cultural rituals, whether religious or non-religious; in many children's complicated routines; in the pathology of obsessive-compulsive disorders (OCD); in normal adults around certain stages of the life-cycle, birthing in particular. Combining evidence from evolutionary anthropology, neuropsychology and neuroimaging, we propose an explanation of ritualized behavior in terms of an evolved Precaution System geared (...) to the detection of and reaction to inferred threats to fitness. This system, distinct from fear-systems geared to respond to manifest danger, includes a repertoire of clues for potential danger as well as a repertoire of species-typical precautions. In OCD pathology, this system does not supply a negative feedback to the appraisal of potential threats, resulting in doubts about the proper performance of precautions, and repetition of action. Also, anxiety levels focus the attention on low-level gestural units of behavior rather than on the goal-related higher-level units normally used in parsing the action-flow. Normally automatized actions are submitted to cognitive control. This “swamps” working memory, an effect of which is a temporary relief from intrusions but also their long-term strengthening. Normal activation of this Precaution System explains intrusions and ritual behaviors in normal adults. Gradual calibration of the system occurs through childhood rituals. Cultural mimicry of this system's normal input makes cultural rituals attention-grabbing and compelling. A number of empirical predictions follow from this synthetic model. (Published Online February 8 2007) Key Words: childhood ritual; compulsion; event boundaries; evolutionary psychology; obsessive-compulsive disorder; ritual; thought intrusion. (shrink)

In reply to commentary on our target article, we supply further evidence and hypotheses in the description of ritualized behaviors in humans. Reactions to indirect fitness threats probably activate specialized precaution systems rather than a unified form of danger-avoidance or causal reasoning. Impairment of precaution systems may be present in pathologies other than obsessive-compulsive disorder (OCD), autism in particular. Ritualized behavior is attention-grabbing enough to be culturally transmitted whether or not it is associated with group identity, cohesion, or with any (...) other social aspect of collective ceremonies. (Published Online February 8 2007). (shrink)

This article seeks to explain how and why groups and networks of undocumented migrants mobilizing in Berlin, Montréal, and Paris since the beginning of the 2000s construct different types of claims. The authors explore the relationship between undocumented migrants and state authorities at the local level through the concept of the citizenship regime and its specific application to undocumented migrants. Despite their common formal exclusion from citizenship, nonstatus migrants experience different degrees and forms of exclusion in their daily lives, in (...) terms of access to certain rights and services, recognition, and belonging within the state. As a result, they have an opportunity to create different, specific forms of leeway in the society in which they live. The concurrence of these different degrees of exclusion and different forms of leeway defines specific conditions of mobilization. The authors demonstrate how the content of their claims is influenced by these conditions of mobilization. (shrink)

To study the interaction of forces that produce chest wall motion, we propose a model based on the lever system of Hillman and Finucane (J Appl Physiol 63(3):951–961, 1987 ) and introduce some dynamic properties of the respiratory system. The passive elements (rib cage and abdomen) are considered as elastic compartments linked to the open air via a resistive tube, an image of airways. The respiratory muscles (active) force is applied to both compartments. Parameters of the model are identified in (...) using experimental data of airflow signal measured by pneumotachography and rib cage and abdomen signals measured by respiratory inductive plethysmography on eleven healthy volunteers in five conditions: at rest and with four level of added loads. A breath by breath analysis showed, whatever the individual and the condition are, that there are several breaths on which the airflow simulated by our model is well fitted to the airflow measured by pneumotachography as estimated by a determination coefficient R 2 ≥ 0.70. This very simple model may well represent the behaviour of the chest wall and thus may be useful to interpret the relative motion of rib cage and abdomen during quiet breathing. (shrink)

New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Eight papers followed by a discussion and an epilogue.

Background: Maximum safe resection of infiltrative brain tumors in eloquent area is the primary objective in surgical neuro-oncology. This goal can be achieved with direct electrical stimulation to perform a functional mapping of the brain in patients awake intraoperatively. When awake surgery is not possible, we propose a pipeline procedure that combines advanced techniques aiming at performing a dissection that respects the anatomo-functional connectivity of the peritumoral region. This procedure can benefit from intraoperative monitoring with computerized tomography scan and brain (...) shift correction. Associated with this intraoperative monitoring, the additional value of preoperative investigation combining brain mapping by navigated transcranial magnetic stimulation with various neuroimaging modalities has not yet been reported.Case Report: A 42-year-old left-handed man had increased intracranial pressure, left hand muscle deficit, and dysarthria, related to an infiltrative tumor of the right frontal lobe with large mass effect and circumscribed contrast enhancement in motor and premotor cortical areas. Spectroscopy profile and intratumoral calcifications on CT-scan suggested an WHO grade III glioma, later confirmed by histology. The aforementioned surgical procedure was considered, since standard awake surgery was not appropriate for this patient. In preoperative time, nTMS mapping of motor function was performed, combined with magnetic resonance imaging -based tractography reconstruction of 6 neural tracts and resting-state functional MRI connectivity of sensorimotor and language networks. In intraoperative time, DES mapping was performed with motor evoked response recording and tumor resection was optimized using non-rigid image transformation of the preoperative data to iCT data. Image guidance was updated with correction for brain shift and tissue deformation using biomechanical modeling taking into account brain elastic properties. This correction was done at crucial surgical steps, i.e., when tumor bulged through the craniotomy after dura mater opening and when approaching the presumed eloquent brain regions. This procedure allowed a total resection of the tumor region with contrast enhancement as well as a complete regression of IICP and dysarthria. Hand paresis remained stable with no additional deficit. Postoperative nTMS mapping confirmed the good functional outcome.Conclusion: This case report and technical note highlights the value of preoperative functional evaluation by nTMS updated intraoperatively with correction of brain deformation by iCT. This multimodal approach may become the optimized technique of reference for patients with brain tumors in eloquent areas that are unsuitable for awake brain surgery. (shrink)

In medical research, the ethical principle of respect for persons is operationalized into the process of informed consent. The consent tools should be contextualized and adapted to the different socio-cultural environment, especially when research crosses the traditional boundaries and reaches poor communities. We look at the challenges experienced in the malaria Quinact trial, conducted in the Democratic Republic of Congo, and describe some lessons learned, related to the definition of acceptable representative, the role of independent witness and the impact of (...) socio-economic vulnerability. To ensure children's protection, consent is required by the parents or, in their absence, by a legally mandated representative. In our setting, children's responsibility is often entrusted permanently or temporarily to relatives or friends without a tribunal mandate. Hence, a notion of ‘culturally acceptable representative’ under supervision of the local Ethics Committee may be more suitable. To ensure protection of illiterate subjects, an independent witness is required to confirm that the consent was freely given. However, in low-literacy contexts, potential witnesses often don't have any previous relationship with patient and there may be power-unbalance in their relationship, rather than genuine dialogue. In poor communities, trial participation may be seen as an opportunity to secure access to healthcare. Poverty may also lead to ‘competition’ to access the research-related benefits, with a risk of disturbance at societal or household level. Adjusting consent procedures to sociocultural and socioeconomic realities is essential for fulfilling the underlying ethical principles. This requires a collaborative dialogue between researchers, regulators and ethics committees. (shrink)

Cet article associe trois approches issues de l’institutionnalisme historique : l’école historique allemande, l’institutionnalisme américain originel et la théorie de la régulation. Il en dégage les principes méthodologiques partagés et analyse leur application au processus d’élaboration théorique. Codes JEL : B15, B25, B40, B52, E02, Z13.

Cet article associe trois approches issues de l’institutionnalisme historique : l’école historique allemande, l’institutionnalisme américain originel et la théorie de la régulation. Il en dégage les principes méthodologiques partagés et analyse leur application au processus d’élaboration théorique. Codes JEL : B15, B25, B40, B52, E02, Z13.

The field programmable gate array implementation of the nonlinear resistor-capacitor-inductor shunted Josephson junction model and its application to sEMG signal encryption through image encrypted technique are reported in this study. Thanks to the numerical simulations and FPGA implementation of the NRCISJJ model, different shapes of chaotic attractors are revealed by varying the parameters. The chaotic behaviour found in the NRCISJJ model is used to encrypt the sEMG signal through image encryption technique. The results obtained are interesting and open up many (...) perspectives. (shrink)

Philosophe, moraliste, inventeur de machines et de formes, mathématicien, physicien, théologien, polémiste... Blaise Pascal semble avoir eu mille visages. Mais de lui, finalement, que sait-on vraiment? En suivant l'écrivain pas à pas, de sa naissance à Clermont à sa mort à Paris, Pierre Lyraud nous dévoile les lignes de force d'une vie prématurément écourtée, mais passionnée par la recherche constante d'une vérité blessée par les troubles de son temps. C'est alors un nouveau visage de Pascal qui nous (...) apparaît, celui d'un penseur de la joie et de la grandeur de l'âme humaine; d'un honnête homme soucieux de vulgarisation; d'un ardent chrétien inquiet de l'avenir des autres; d'un plein vivant se rendant peu à peu compte que la vie véritable n'est pas celle du monde. Un parcours inédit dans l'œuvre de l'un des plus grands auteurs français"--Page 4 of cover. (shrink)

Although complex hallucinations are extremely vivid, painful symptoms in schizophrenia, little is known about the underlying mechanisms of multisensory integration in such a phenomenon. We investigated the neural basis of these altered states of consciousness in a patient with schizophrenia, by combining state of the art neuroscientific exploratory methods like functional MRI, diffusion tensor imaging, cortical thickness analysis, electrical source reconstruction and trans-cranial magnetic stimulation. The results shed light on the functional architecture of the hallucinatory processes, in which unimodal information (...) from different modalities is strongly functionally connected to higher-order integrative areas. (shrink)

Au paragraphe 15 du De emendatione intellectus, Spinoza mentionne une doctrina de puerorum educatione au titre d’un élément intégré à part entière à son projet philosophique. Mais, cette « doctrine », il ne l’a jamais écrite en tant que telle, et elle constitue dans son œuvre une sorte de pièce manquante : en tout cas, la question de l’enfant et de sa formation n’y figure que de façon marginale, sous forme de traces que Pascal Sévérac exploite comme des « (...) indices » en vue de mener une « enquê... (shrink)

Découvert en 1981 près de l'angle Nord-Est du palais de Malia, un triton en chlorite porte une décoration et une représentation sculptées en relief. On y voit deux génies léonins à carapace dressés face à face sur un piédestal : l'un tient une cruche à double bec et semble en présenter le contenu à l'autre qui porte ses antérieurs à sa gueule. L'analyse de l'objet, des éléments du décor et de la représentation conduisent à reconnaître dans ce triton une réalisation (...) égéenne datant du MR I A. Il paraît plus vraisemblable de l'interpréter comme rhyton que comme une trompette. Une annexe présente les autres coquillages en pierre, en terre cuite et en faïence trouvés dans le monde égéen. (shrink)

III. INTERPRÉTATION ET CONTRARIÉTÉS 1. Contrariétés et apologétique Le Père Garasse justifie l'existence de contradictions dans la Bible en comparant les Ecritures au corpus des textes législatifs, que les juristes ont souvent du mal à ...