Background: Maximum safe resection of infiltrative brain tumors in eloquent area is the primary objective in surgical neuro-oncology. This goal can be achieved with direct electrical stimulation to perform a functional mapping of the brain in patients awake intraoperatively. When awake surgery is not possible, we propose a pipeline procedure that combines advanced techniques aiming at performing a dissection that respects the anatomo-functional connectivity of the peritumoral region. This procedure can benefit from intraoperative monitoring with computerized tomography scan and brain (...) shift correction. Associated with this intraoperative monitoring, the additional value of preoperative investigation combining brain mapping by navigated transcranial magnetic stimulation with various neuroimaging modalities has not yet been reported.Case Report: A 42-year-old left-handed man had increased intracranial pressure, left hand muscle deficit, and dysarthria, related to an infiltrative tumor of the right frontal lobe with large mass effect and circumscribed contrast enhancement in motor and premotor cortical areas. Spectroscopy profile and intratumoral calcifications on CT-scan suggested an WHO grade III glioma, later confirmed by histology. The aforementioned surgical procedure was considered, since standard awake surgery was not appropriate for this patient. In preoperative time, nTMS mapping of motor function was performed, combined with magnetic resonance imaging -based tractography reconstruction of 6 neural tracts and resting-state functional MRI connectivity of sensorimotor and language networks. In intraoperative time, DES mapping was performed with motor evoked response recording and tumor resection was optimized using non-rigid image transformation of the preoperative data to iCT data. Image guidance was updated with correction for brain shift and tissue deformation using biomechanical modeling taking into account brain elastic properties. This correction was done at crucial surgical steps, i.e., when tumor bulged through the craniotomy after dura mater opening and when approaching the presumed eloquent brain regions. This procedure allowed a total resection of the tumor region with contrast enhancement as well as a complete regression of IICP and dysarthria. Hand paresis remained stable with no additional deficit. Postoperative nTMS mapping confirmed the good functional outcome.Conclusion: This case report and technical note highlights the value of preoperative functional evaluation by nTMS updated intraoperatively with correction of brain deformation by iCT. This multimodal approach may become the optimized technique of reference for patients with brain tumors in eloquent areas that are unsuitable for awake brain surgery. (shrink)

The history of the relations between Leibniz and Spinoza is a matter of philosophical and scholarly controversy. This chapter aims to refer to the first thesis as the Necessity of Actuality and to the second thesis as the Plenitude of Possibilities. It examines how Leibniz's stance with respect to these two theses, and more generally his views on modality, grew out as a response to Spinoza's views. Leibniz explicitly connects Spinoza's attributes with the concept of a world. As most commentators, (...) Leibniz reads Spinoza as a necessitarian, which is a natural interpretation. The difference between Leibniz's and Spinoza's views would reside in their conceptions of God and of the mechanism whereby the actual world comes to exist. Leibniz entertains the hypothesis of reality encompassing a plurality of actual worlds, which seems to achieve the Plenitude of Possibility. (shrink)

ABSTRACT:The purpose of this paper is to critically evaluate the instrumental perspective on Corporate Social Responsibility (CSR) in practice and theory by relying on sociological analyses of a well known organization: the Italian Mafia. Legal businesses might share features of the Mafia, such as the propensity to exploit a governance vacuum in society, a strong organizational identity that demarcates the inside from the outside, and an extreme profit motive. Instrumental CSR practices have the power to accelerate a firm's transition to (...) Mafia status through its own pathologies. The boundaries of such instrumentalism are explored and lessons for future CSR research derived, with specific emphasis on a firm's social and normative embeddedness, taking into account the inherent challenge of regulating corporate behaviour in the global economy. (shrink)

Age‐related and cancer‐related epigenomic modifications have been associated with enhanced cell‐to‐cell gene expression variability that characterizes increased cellular stochasticity. Since gene expression variability appears to be highly reduced by—and epigenetic and phenotypic stability acquired through—direct or long‐range cellular interactions during cell differentiation, we propose a common origin for aging and cancer in the failure to control cellular stochasticity by cell–cell interactions. Tissue‐disruption‐induced cellular stochasticity associated with epigenetic drift would be at the origin of organ dysfunction because of an increase in (...) phenotypic variation among cells, ultimately leading to cell death and organ failure through a loss of coordination in cellular functions, and eventually to cancerization. We propose mechanistic research perspectives to corroborate this hypothesis and explore its evolutionary consequences, highlighting a positive correlation between the median age of mass loss onset (a proxy for the onset of organ aging) and the median age at cancer diagnosis. (shrink)

How to reconcile monadic simplicity with the successive plurality of the monadic states ? The doctrine of continued creation seems to entail the existence of independent temporal parts and thus lead to the thesis that the world contains only transitory things. I try to show how Leibniz has the resources to get out of this quandary. The analysis of the concept of extension shows that a plurality of states does not constitute a divisible aggregate. Then I examine the Leibnizian interpretation (...) of continued creation, by com- paring it to the scholastic and Cartesian Background. From thence I conclude that Leibniz’s final thesis is that monads are wholly present at each moment of their duration. (shrink)

Social reporting has become an increasingly important dimension of the corporate social responsibility process. The growing necessity to include the social dimension in reporting practices raises important questions about the nature of social responsibility and its impact on corporate and individual behaviour and performance. The literature has yet to provide a reliable theoretical definition of corporate social responsibility and performance, however. Based on the approach proposed by Simons, we argue that organisational reporting about social responsibility can be viewed as a (...) learning tool in some instances. Under this view the design and implementation of corporate social reporting procedures may lead to individual and organisational dynamic changes that foster organisational performance. Research propositions are then derived from the analysis. (shrink)

Despite the extensive literature describing the somatic genetic alterations in cancer cells, the precise origins of cancer cells remain controversial. In this article, I suggest that the etiology of cancer and the generation of genetic instability in cancer cells should be considered in the light of recent findings on both the stochastic nature of gene expression and its regulation at tissue level. By postulating that gene expression is intrinsically probabilistic and that stabilization of gene expression arises by cellular interactions in (...) “morphogenetic fields”, development and cellular differentiation can be rethought in an evolutionary perspective. In particular, this article proposes that disruptions of cellular interactions are the initial source of abnormal gene expression in cancer cells. Consequently, cancer phenotypes such as genetic and epigenetic instabilities, and also the presence of cells with stem cell‐like properties, may result from inaccurate and aberrant patterns of gene expression generated by microenvironmental alterations. Finally, the therapeutic implications of this view are discussed. BioEssays 27:1277–1285, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

This study shows how institutional work contributes to institutional resilience in extreme operating environments. The authors draw from a longitudinal analysis of the operations of Desjardins International Development, a French Canadian nongovernmental organization that, both before and after the major earthquake of 2010, supported the implementation of cooperative banking in Haiti. Building on a unique access to DID’s internal documents as well as on 49 interviews with DID employees, the authors highlight the ways in which political, technical, and cultural forms (...) of institutional work triggered the emergence of social capital, which in turn supported the rise of new forms of institutional work that enabled institutional resilience. The results show how organizational activities focused on shaping institutions may have unintended effects that enable institutional resilience in EOEs, and demonstrate how the accumulation of institutional work by an organization contributes to the enhancement of its social capital. (shrink)

Building a coherent discourse on professionalism is a challenge for corporate social responsibility practitioners, as there is not yet an established knowledge basis for CSR, and CSR is a contested notion that covers a wide variety of issues and moral foundations. Relying on insights from the literature on micro-CSR, new professionalism, and Boltanski and Thévenot’s economies of worth framework, we examine the discourses of 56 CSR practitioners in South Korea on their claimed professionalism. Our analysis delineates four distinct discourses of (...) CSR professionalism—strategic corporate giving, social innovation, risk management, and sustainability transition—that are derived from a plurality of more or less compatible moral foundations whose partial overlaps and tensions we document in a systematic manner. Our results portray these practitioners as compromise makers who selectively combine morally distant justifications to build their own specific professionalism discourse, with the aim to advance CSR within and across organizations. By uncovering the moral relationality connecting these discourses, our findings show that moral pluralism is a double-edged sword that can not only bolster the justification of CSR professionalism but also threaten collective professionalism at the field level. Overall, our study suggests paying more attention to the moral relationality and tensions that underlie professional fields. (shrink)

The relation between extension and impenetrability is a major issue in the Descartes-More correspondence, which implies an analysis of the concept of extension. The mereological structure partes extra partes is a crucial element here. Both philosophers hold two opposed views of this mereological structure. I try to show that these two views can be traced back to scholastic discussions on quantity’s relation to extension. This background provides a vantage point, which enables to propose a new construal of the argumentative exchange (...) around impenetrability, and which casts some light too on our understanding of two properties – spissitude and indiscerpibility – which More attributes to spiritual extension in his later writings. (shrink)

Est-il possible de parler de ce qui n’est pas ou d’y penser sans présupposer une forme d’être pour cela même que nous pensons ne pas exister? La vieille énigme parménidienne, qui hante toujours la philosophie contemporaine, est au cœur non seulement de la philosophie médiévale mais aussi des études médiévales, comme en témoigne le récent ouvrage d’Alain de Libera sur la référence vide. L’objet de cette étude est en comparaison beaucoup plus...

La compossibilité chez Leibniz est la relation qui répartit les possibles en mondes distincts. Un problème central consiste à comprendre pour quelle raison tous les possibles ne sont pas compossibles, ou ce qui fonde la pluralité des mondes possibles. On examine ici ce problème en confrontant les thèses de Leibniz au réalisme modal de Lewis. Chez ce dernier, l’appartenance à un même monde est définie par l’existence de relations spatiotemporelles, ce qui exclut la possibilité d’univers-îles, ou mondes sans connexion spatiotemporelle (...) et permet de conclure à l’impossibilité qu’un monde contienne la totalité des possibles. L’interprétation cosmologique de la compossibilité attribue une position semblable à Leibniz. Mais cette interprétation exige de tenir l’harmonie expressive pour une caractéristique nécessaire de tous les mondes, ce qui est incompatible avec un certain nombre d’affirmations de Leibniz. (shrink)

This paper examines the problem of the basis of time’s asymmetry. I hold the view that there is an objective temporal asymmetry in Leibniz’s philosophy of time. I closely examine various asymmetrical phenomena, which can be candidates as an explanation of time’s asymmetry: (1) causation; (2) the flow of time; (3) the modal difference between past and present; (4) counterfactual dependence; and, finally (5) the asymmetry of the world’s progress and its direction and (6) of the progress of rational creatures. (...) I conclude that time’s asymmetry involves an irreducibly pragmatic aspect: the asymmetry of agency itself on which all other asymmetrical phenomena rely. (shrink)

Graphical AbstractCurrent differentiation therapies for cancer may not be effective because it might not be enough to only use molecules targeting chromatin remodelers. It may also be necessary to stabilize the re-expressed genes to convert malignant cells into benign ones.

During the seventeenth century, disputes over middle knowledge centered on the following question: does God know contingent states of affairs before He decrees to bring them about (the Jesuit view); or, conversely, does He know them after He has decreed which states of affairs He will bring about (the Dominican view)? This article intends to cast some light on Leibniz’s view of this question. Of central importance here is the notion of a possible decree (designed both to ground contingency and (...) to explain God’s knowledge). Despite his apparent proximity to the Dominican view, Leibniz maintained the prevolitional nature of God’s knowledge of contingent states of affairs. In order to establish this point, Leibniz’s view is compared to some little known developments in the theory of middle knowledge. (shrink)

In this paper, I examine a neglected debate between Francisco Suárez and Pedro Hurtado de Mendoza about the unity of composite substances. There was a consensus among the Jesuits on the fact that the per se unity of composite substances requires something in addition to matter and form. Like most Jesuits, Suárez and Hurtado further agree on the fact that this additional ingredient is not a full-blown thing, but a “mode of union.” However, while Suárez claims that the union is (...) achieved through a single mode, Hurtado maintains that it is necessary to postulate two distinct modes of union, one modifying form and another modifying matter. I argue that this disagreement actually reflects an important ontological debate about the nature of the items that serve as the cement of things and that it eventually leads later Jesuits like Rodrigo de Arriaga to conceive of union as a polyadic or “straddling” mode. (shrink)

Un enjeu central de la correspondance entre Descartes et More concerne le rapport entre étendue et impénétrabilité et implique ainsi l’analyse du concept d’étendue. Dans celle-ci, la discussion de la structure méréologique partes extra partes est essentielle. Ces deux philosophes comprennent de deux manières différentes la nature de ce rapport méréologique et on essaie de montrer que cette double compréhension trouve son origine dans les discussions scolastiques sur les rapports entre quantité et étendue. C’est à partir de l’éclairage apporté par (...) ce contexte scolastique que l’on relit l’échange d’arguments entre Descartes et More autour de l’impénétrabilité et que l’on analyse deux propriétés – spissitude et indiscerpibilité – que More attribue dans ses textes tardifs à l’étendue spirituelle. (shrink)

La necessite, bien qu'elle soit centrale en philosophie, est une notion particulierement difficile a elucider. Cet ouvrage tente d'en clarifier le contenu, en la distinguant notamment des notions voisines d'a priori et de l'analytique. Il presente egalement differentes approches reductionnistes de la necessite: le reductionnisme ontique (les theories des mondes possibles), le conventionnalisme ou encore le non-cognitivisme (la necessite provient des bornes de nos capacites cognitives). Le commentaire du texte de Descartes montre d'ailleurs que ces theses contemporaines apportent un eclairage (...) nouveau a l'interpretation de sa doctrine de la creation des verites eternelles. Enfin, l'un des enjeux de cet ouvrage est de defendre la legitimite de la notion de necessite contre l'idee selon laquelle elle serait scientifiquement inutile et metaphysiquement suspecte. Au contraire, recentree sur l'idee de necessite a posteriori analysee par Kripke et en connexion avec la notion d'essence, la necessite s'avere etre une notion philosophiquement feconde. (shrink)

This article bears on the topic of the temporal persistence of particulars in Leibniz's philosophy. It is focused on an analysis of some passages from definitional notes from the early 1680's where Leibniz sets out his main metaphysical theses. The paper contends that Leibniz analysed the identity of substances within a broadly Aristotelian framework, i. e. in terms of enduring metaphysical items (which are identical and wholly present at each moment of the particular's existence). It thus opposes an explanation in (...) terms of an atemporal substantial form, or law, causally unifying instantaneous states. Moreover it will be shown that (i) while Leibniz had some important insights into the possibility of what recent philosophers labelled a "perdurantist" account of persistence, (ii) he nevertheless had strong reasons given other theses of his system to reject an ontology of aggregates made of temporal parts in favour of a traditional, "endurantist" conception. (shrink)

À partir de l’analyse d’un argument présenté dans la correspondance avec More, cette étude examine la conception cartésienne du rapport de l’étendue à l’impénétrabilité à travers le prisme de l’imagination. Je montre que l’argument en question est une expérience de pensée qui s’appuie sur le caractère inimaginable d’une étendue pénétrable. Je défends l’idée selon laquelle la conception proprement cartésienne de l’imagination implique que le contenu et les limites de nos actes d’imagination dépendent des propriétés des images cérébrales. J’en déduis que (...) cette conception particulière de l’imagination explique pourquoi l’argument des lettres à More est concluant du point de vue de Descartes. (shrink)

This paper explores the scholastic context of the discussion about the unity of the composite or corporeal substance and the nature of the vinculum substantiale or substantial bond in Leibniz’s correspondence with Des Bosses. Three prominent scholastic views are examined: Duns Scotus’s antireductionist account of the composite substance as an entity irreducible to its essential parts ; Ockham’s parts-whole identity thesis, which entails a reductionist view of the composite substance; and Suárez’s explanation of the unity of composite substance through the (...) presence of a substantial mode of union. It is then shown that Leibniz initially combines a reductionist account of the composite substance, with the vinculum playing the role of bond among the component monads. In his last letters, he moves away from this to an antireductionist account of the composite substance, with which he now identifies the vinculum. (shrink)

Despite their central role in the construction and development of the market for virtues as well as in the design, implementation, and evaluation of corporate sustainability strategies and governmental sustainability policies, sustainability consultants remain at best “hidden” corporate change agents. In this paper, we bring sustainability consultants back to the fore to account for how these actors discreetly regulate and shape contemporary sustainability transformations from the outside-in. We do so first by unpacking various roles of consultants as engineers, market builders, (...) power vehicles, boundary workers, issue translators, and soft regulators; then we conceptualize how, through these roles, they contribute to empowering, legitimizing but also potentially supplanting and undermining the activities of corporate change agents operating inside corporations. We finally propose some research orientations for studying further the role of sustainability consultants in corporate transformations toward sustainability. (shrink)

Stochastic gene expression plays a leading developmental role through its contribution to cell differentiation. It is also proposed to promote phenotypic diversification in malignant cells. However, it remains unclear if these two forms of cellular bet‐hedging are identical or rather display distinct features. Here we argue that bet‐hedging phenomena in cancer cells are more similar to those occurring in unicellular organisms than to those of normal metazoan cells. We further propose that the atavistic bet‐hedging strategies in cancer originate from a (...) hijacking of the normal developmental bet‐hedging of metazoans. Finally, we discuss the constraints that may shape the atavistic bet‐hedging strategies of cancer cells. (shrink)

The purpose of this paper is to provoke a debate on the management of social issues building on the analysis of a well known illegal organization, namely theSicilian Mafia. According to the analytical framework provided by Gambetta (1993), the Sicilian Mafia could be considered as a business on its own dealing a specific commodity: the ‘protection of people’. That approach of ‘Mafia as a corporation’ allows investigating the social responsibility of that organization and the way the Mafia managed its key (...) stakeholders. As we will argue, the recent spate of corporate scandals reveals the risk of normal corporations turning into a Mafia type of organization. One of the key drivers of those scandals is the overstretched instrumental interpretation of a corporation's societal responsibilities. By caricaturing and perverting some established practices of the mainstream approach to CSR perspective, we will demonstrate the potential pathologies of a CSR approach that is mainly based on the neoliberal foundation of individual and organizational self-interest. (shrink)

The purpose of this paper is to provide a theoretical framework to investigate ‘CSP-FP relationship’ as a social construction on financial markets. The construction of such a relationship has become a crucial business problem since the legitimacy-building process of actors implied in markets related to corporate social responsibility evaluation and management is closely associated to the belief that ‘ethics and/or social responsibility pay’ – at least in the long run. Consequently, actors’ behaviours and beliefs on these markets can no longer (...) be considered as external to the CSP-FP debate, but should be integrated as an endogenous variable. Moreover, the diffusion of these behaviours and beliefs could also contribute to the effective realization of such a relationship on financial markets and, to some extent, in the business arena. These facts offer the opportunity to reframe theoretically the classical and over-studied debate around ‘the CSP-FP link’ and to propose a new framework describing the various processes of performativity through which actors enact and construct the positive relationship between CSP and FP. (shrink)

This paper provides a summary of the symposium on the institutional and social construction of Responsible Investment (RI), held at the 22nd IABS conference. In the context of the symposium, we propose to move beyond the dominant focus on the financial impact of RI to consider the potential of emergent institutional and sociological perspectives to explain the practices and concepts related to RI. In doing so, our aim is to explore in greater detail the current changes in the RI infrastructure (...) and the impact of these changes on wider issues of corporate sustainability and social responsibility. (shrink)

The purpose of this paper is to provoke a debate on the management of social issues building on the analysis of a well known illegal organization, namely theSicilian Mafia. According to the analytical framework provided by Gambetta (1993), the Sicilian Mafia could be considered as a business on its own dealing a specific commodity: the ‘protection of people’. That approach of ‘Mafia as a corporation’ allows investigating the social responsibility of that organization and the way the Mafia managed its key (...) stakeholders. As we will argue, the recent spate of corporate scandals reveals the risk of normal corporations turning into a Mafia type of organization. One of the key drivers of those scandals is the overstretched instrumental interpretation of a corporation's societal responsibilities. By caricaturing and perverting some established practices of the mainstream approach to CSR perspective, we will demonstrate the potential pathologies of a CSR approach that is mainly based on the neoliberal foundation of individual and organizational self-interest. (shrink)

The purpose of this article is to investigate how Human Resources (HR) contributes to responsible leadership. Although Corporate Social Responsibility (CSR) practices have been embraced by many corporations in recent years, the specific contributions of HR professionals, HR management practices and employees to responsible leadership have been overlooked. Relying on the analysis of interviews with 30 CSR and HR corporate executives from 22 corporations operating in France, we specify the HR contributions to responsible leadership at the functional, practical, and relational (...) levels of analysis. We analyze whether and how HR support employees’ involvement in CSR, and highlight areas of collaboration and tension between HR and CSR functions around emerging practices of responsible leadership. Our findings uncover the multiple yet often implicit roles of HR in responsible leadership as well as the interrelation between functional, practical and relational dimensions of these roles. Finally, this study suggests that the organization of the HR–CSR interface can enable or undermine the HR contributions to responsible leadership and points to underlying cognitive factors that shape the HR–CSR interface. (shrink)

Réduction du temps de travail, 35 heures, flexibilité accrue, vieillissement de la population, développement des loisirs, usage croissant des nouvelles technologies de l'information, autant de facteurs souvent évoqués comme responsables de ce qui serait une fluidification progressive de nos rythmes de vie. Certains vont même jusqu'à anticiper une ville 24 h sur 24, perpétuellement en mouvement... Pourtant l'analyse par Jean-Pascal Lavielle d'une série d'Enquêtes Ménages Déplacements étalées - Urbanisme – Nouvel article.