DNA transfer directly from cell to cell (conjugation) is common among prokaryotes, particularly Gram‐negative bacteria like Escherichia coli. The phenomenon invariably requires a set of plasmid genes in the DNA donor cell. In addition, E. coli itself makes limited and specific contributions to the donor activity of strains carrying the conjugative plasmid F. These contributions have yet to be defined biochemically, but it is already clear that the cell envelope is an importan nexus between plasmid‐ and chromosome‐encoded proteins required for (...) the establishment and maintenance of DNA donor activity. (shrink)

Providing the most thorough coverage available in one volume, this comprehensive, broadly based collection offers a wide variety of selections in four major genres, and also includes a section on film. Each of the five sections contains a detailed critical introduction to each form, brief biographies of the authors, and a clear, concise editorial apparatus. Updated and revised throughout, the new Fourth Edition adds essays by Margaret Mead, Russell Baker, Joan Didion, Annie Dillard, and Alice Walker; fiction by Nathaniel Hawthorne, (...) Ursula K. LeGuin, Anton Chekov, James Joyce, Katherine Mansfield, F. Scott Fitzgerald, William Faulkner, Alice Walker, Louise Erdrich, Donald Barthelme, and James McPherson; poems by John Donne, Robert Browning, Walt Whitman, Edwin Arlington Robinson, e.e. cummings, Langston Hughes, W.H. Auden, Philip Levine, and Louise Gluck; and plays by August Wilson, Marsha Norman, Wendy Wasserstein, and Vaclav Havel. The chapter devoted to film examines the relation of film to literature and gives the complete screenplay for Citizen Kane plus close analysis of a scene from the film. With its innovative structure, comprehensive coverage, and insightful and stimulating presentation of all kinds of literature, this is an anthology readers will turn to again and again. (shrink)

Philip Pettit offers a new insight into moral psychology. He shows that attachments such as love, and certain virtues such as honesty, require their characteristic behaviours not only as things actually are, but also in cases where things are different from how they actually are. He explores the implications of this idea for key moral issues.

Presents general information about meteorology, weather, and climate and includes more than thirty activities to help study these topics, including making a ...

Since its publication in 1966, The Triumph of the Therapeutic has been hailed as a work of genuine brilliance, one of those books whose insights uncannily anticipate cultural developments and whose richness of argumentation reorients entire fields of inquiry. This special fortieth-anniversary edition of Philip Rieff’s masterpiece, the first volume in ISI Books’ new Background series, includes an introduction by Elisabeth Lasch-Quinn and essays on the text by historians Eugene McCarraher and Wilfred McClay and philosopher Stephen Gardner.

In this short, elegant book, Philip Kitcher distills the case for Darwinian evolutionary theory and its implications in a clear and forceful way. Kitcher shows how the alleged rivals to Darwinism, like Intelligent Design, are essentially scientifically bankrupt - and that scientific discoveries, including Darwin's, pose a genuine problem for religious faith, one that neither Darwin's opponents nor his militant defenders have satisfactorily resolved.

This is the first complete English translation of Gottlob Frege's Grundgesetze der Arithmetik, with introduction and annotation. The importance of Frege's ideas within contemporary philosophy would be hard to exaggerate. He was, to all intents and purposes, the inventor of mathematical logic, and the influence exerted on modern philosophy of language and logic, and indeed on general epistemology, by the philosophical framework.

This is a book about the aesthetics of wonder, about wonder as it figures in our relation to the visual world and to rare or new experiences.

What characteristics or attributes of a healthcare decision qualify it as acceptable to those who are empowered to judge it as adequate and hence suitable to either proceed (or not) with a recommen...

Philip Pettit; X*—Social Holism and Moral Theory: A Defence of Bradley's Thesis, Proceedings of the Aristotelian Society, Volume 86, Issue 1, 1 June 1986, Pages.

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

"My interest in [Max] Scheler's critique of Kant runs back nearly a decade.... The more I read of Scheler, the more I began to see the value of a project dealing with his critique of Kant in Der Formalismus in der Ethik und die Materiale Wetethik, which would possess the virtue of focusing in a single project three important strands of philosophical interest: phenomenology, Kantianism, and ethics.... "The study is divided into six chapters and two appendices. Each of the chapters (...) constituting the body of the work contains a brief analysis of the Kantian position or discussion of the basic questions at issue in it, an exposition of Scheler's critique of the Kantian position and its presuppositions, and a detailed appraisal of Scheler's critique." -- from the introduction by the author. (shrink)

Argues i) that part of what it is to understand what is being asked, when we ask whether something is good, is being able to distinguish stopping points in a series of "Why?" questions, and ii) that this ability explains how we can reason from observable facts to conclusions about value.

(2013). Cognitive shortcuts in causal inference. Argument & Computation: Vol. 4, Formal Models of Reasoning in Cognitive Psychology, pp. 64-88. doi: 10.1080/19462166.2012.682655.

Can it make sense for someone who appreciates the explanatory power of modern science to continue believing in a traditional religious account of the ultimate nature and purpose of our universe?

Introduction -- The univocity of being -- The modern predicament -- The problem of univocity in ancient and medieval philosophy -- From Heidegger to Aristotle -- Medieval philosophy -- Scholasticism -- Heidegger, Scotus, and univocity -- The question of being -- Analogy, the medieval experience of life -- Univocity and phenomenology -- Destruction and tradition -- Metaphysics -- Phenomenological philosophy and aletheia -- Descartes, scholasticism, and time -- The presupposition of the tradition -- Scholasticism, analogy, and the interpretation of Heidegger (...) -- The phenomena of beingness and time -- Beyond being -- The analogical interpretation of Heidegger's text -- Univocity and phenomenological philosophy -- Being and some other key terms -- The phenomenology of being and the question of Dasein -- Transcendental philosophy -- Univocity from 1916 to 1927 -- Cartesian connections and the medieval ontology -- Dasein, univocity, and the question of analogy -- Univocity and fundamental ontology -- Husserl and Heidegger -- Phenomenology, being, and univocity -- Univocity and analogy -- Univocity and Heidegger's later thought -- Mysticism -- The present age -- The later Heidegger -- A-letheia, ereignis, and epochal immanence -- A history of being -- The tradition -- The history of metaphysics -- The medieval and the modern -- A history of the modern : subjectivity -- Univocity and the problem of history -- History and civilization -- Art and history -- Fractured history -- Language and poetry -- The fate of univocity -- The re-enchanted forest -- Being mortal. (shrink)

_Time_ offers a comprehensive history of the philosophy of time in western philosophy from the Greeks through to the twentieth century. In the first half of the book, Philip Turetzky explores theories in ancient and modern philosophy chronologically: from Aristotle to Nietzsche. In the latter half, Turetzky describes the philosophy of time in three twentieth-century philosophical traditions: * analytic philosophy including philosophers such as McTaggart and Mellor * phenomenology Husserl and Heidegger * a distaff tradition which Turetzky identifies as (...) including Bergson and Deleuze. (shrink)

Collected here for the first time, the writings in 'The Feeling Intellect' demonstrate the range and precision of Philip Rieff's sociology of culture.

The philosophies of Merleau-Ponty and the later Wittgenstein are shown to yield a common position opposing 'realist' attempts to reduce appearance, sense, and meaning to perception-independent objects and relations. Their 'Gestalt Philosophy' thus constitutes a new form of 'anti- realism'.

Over the last century, and especially since the publication of the Belmont Report in 1978, respect for persons, as exemplified by respect for autonomous decision-making, has become a central tenet in the practice of medicine. The authority of cognitively competent adults to make their own healthcare decisions is enshrined in both law and practice in most advanced industrialized nations. The right to consent to or to refuse medical interventions is virtually absolute, but is contingent on the provision of materially relevant (...) information about the benefits and burdens or risks of the proposed treatment as well as the freedom from coercion by others, especially healthcare personnel. This power also extends to the kinds, amounts and details of the proposed intervention, including the option to decline to hear anything, if one so chooses, assuming that this is a rational choice. This respect transfers to other competent individuals who are authorized as surrogates to decide for those who have temporarily or permanently lost the capacity to make their own healthcare decisions. (shrink)

A growing literature testifies to the persistence of place as an incorrigible aspect of human experience, identity, and morality. Place is a common ground for thought and action, a community of experienced particulars that avoids solipsism and universalism. It draws us into the philosophy of the ordinary, into familiarity as a form of knowledge, into the wisdom of proximity. Each of these essays offers a philosophy of place, and reminds us that such philosophies ultimately decide how we make, use, and (...) understand places, whether as accidents, instruments, or fields of care. (shrink)

Historical analysis and policy making often require counterfactual thought experiments that isolate hypothesized causes from a vast array of historical possibilities. However, a core precept of Jervis's “systems thinking” is that causes are so interconnected that the historian can only with great difficulty imagine causation by subtracting all variables but one. Prediction, according to Jervis, is even more problematic: The more sensitive an event is to initial conditions (e.g., butterfly effects), the harder it is to derive accurate forecasts. Nevertheless, if (...) awareness of system effects can help forecasters better calibrate their probability estimates of whether or not certain events will come to pass, systems thinkers who are pessimistic about prediction are diluting their confidence too much. The challenge is a meta-cognitive one: thinking systematically about when to engage in systems thinking; and weighing the costs and benefits of using simple or complex heuristics in policy environments that can shift suddenly from quiescence to turbulence. (shrink)

ABSTRACTThis article examines how Christians who had been deprived of the direct sponsorship of the state articulated their claims for political and religious freedom. I examine four cases from the fifth and sixth century in the Eastern Roman Empire and Sasanian Iran. Here I argue that Scriptural models provided an important reservoir of political ideas that could be used by clerics to undermine state authority, whether to underscore the conditional nature of Roman claims to authority or to deny an equality (...) of religious freedom to non-Christian co-citizens. (shrink)

Confucian Reflections: Ancient Wisdom for Modern Times is about the early Chinese Confucian classic the "Analects" Lunyu , attributed to the founder of the Confucian tradition, Kongzi and who is more commonly referred to as "Confucius" in the West. Philip J. Ivanhoe argues that the Analects is as relevant and important today as it has proven to be over the course of its more than 2000 year history, not only for the people who live in East Asian societies but (...) for all human beings. The fact that this text has inspired so many talented people for so long, across a range of complex, creative, rich, and fascinating cultures offers a strong prima facie reason for thinking that the insights the Analects contains are not bound by either the particular time or cultural context in which the text took shape. (shrink)