PHILOSOPHY OF CHANGE — CHANGE IN PHILOSOPHY. REMARKS ON NON-DUALIZING PHILOSOPHY OF JOSEF MITTERER The present paper is aimed at a short presentation of the nondualizing way of speaking formulated by Josef Mitterer, the Austrian philosopher. In the first part I focus on metaphilosophical conception of the non-dualism which is assumed as alternative for the dualizing way of speaking (dominating not only in the philosophical discourses but also in ordinary acts of speech). According to the from-object-cognition (which is understood as (...) the option for traditional epistemology directed towards the object), there is no distinction between object and description. Thus, in the non-dualizing way of speaking, one speaks from the object, not about the object. This is impossible to present the object without a rudimentary description. As a consequence, the discourses are directed towards the change, not toward the truth (which is understood as the aim of the dualizng discourses). In the second part of the paper there is a short critique of Mitterer’s analyses, especially the notion of contingency and the notion of description. Assuming that one can formulate any kind of description from the object, Mitterer reaches the idea of anything goes which is unacceptable also from constructivist point of view (S. Fish’s notions, especially institutional nesting, are used in order to provide more acceptable solution: our conceptions are always based on pre-understandings and conventions). The notion of description, the central point of Mitterer’s deliberations, is involved in dualizing and this seems not to be the best way to present the different way of speaking. (shrink)

This introduction to Epicureanism offers students and general readers a clear exposition of the central tenets of Epicurean philosophy, one of the dominant schools of the Hellenistic period. Founded by Epicurus of Samos (c. 341–270 BCE), it held that for a human being the greatest good was to attain tranquility, free from fear and bodily pain, by seeking to understand the workings of the world and the limits of our desires. Tim O’Keefe provides an extended exegesis of the arguments that (...) support Epicurean philosophical positions, analyzing both their strengths and their weaknesses while showing how the different areas of Epicurean inquiry come together to make a whole. (shrink)

In this book, Tim O'Keefe reconstructs the theory of freedom of the ancient Greek philosopher Epicurus (341-271/0 BCE). Epicurus' theory has attracted much interest, but our attempts to understand it have been hampered by reading it anachronistically as the discovery of the modern problem of free will and determinism. O'Keefe argues that the sort of freedom which Epicurus wanted to preserve is significantly different from the 'free will' which philosophers debate today, and that in its emphasis on rational action it (...) has much closer affinities with Aristotle's thought than with current preoccupations. His original and provocative book will be of interest to a wide range of readers in Hellenistic philosophy. (shrink)

Metaphors used to describe new technologies mediate public understanding of the innovations. Analyzing the linguistic, rhetorical, and affective aspects of these metaphors opens the range of issues available for bioethical scrutiny and increases public accountability. This article shows how such a multidisciplinary approach can be useful by looking at a set of texts about one issue, the use of a newly developed technique for genetic modification, CRISPRcas9.

Epicurus is strongly committed to psychological and ethical egoism and hedonism. However, these commitments do not square easily with many of the claims made by Epicureans about friendship: for instance, that the wise man will sometimes die for his friend, that the wise man will love his friend as much as himself, feel exactly the same toward his friend as toward himself, and exert himself as much for his friend's pleasure as for his own, and that every friendship is worth (...) choosing for its own sake. These claims have led some scholars to assert that Epicurus inconsistently affirms that friendship has an altruistic element. I argue that the Epicurean claims about friendship can be reconciled with egoism and hedonism in psychology and ethics. Friendship is valuable because having friends provides one with security more effectively than any other means, and having confidence that one will be secure in the future either is identical to ataraxia, or the grounds on which one has it. (shrink)

Focuses on the theories of the Epicureans and Cyrenaics in light of Plato's and Aristotle's criticisms of hedonism. Closes with a brief discussion of how the Pyrrhonian skeptical conception of the telos compares to the Epicureans'.

David Furley's work on the cosmologies of classical antiquity is structured around what he calls "two pictures of the world." The first picture, defended by both Plato and Aristotle, portrays the universe, or all that there is (to pan), as identical with our particular ordered world-system. Thus, the adherents of this view claim that the universe is finite and unique. The second system, defended by Leucippus and Democritus, portrays an infinite universe within which our particular kosmos is only one of (...) countless kosmoi. Aristotle's argument in De caelo I.9 that the world is necessarily unique is an important contribution to this debate. This argument holds interest because it shows Aristotle wrestling with an apparent inconsistency in his own philosophy, as deeply-held convictions within his cosmology collide with an equally deeply-held conviction within his metaphysics. The following three principles, each of which Aristotle appears committed to, are inconsistent: -/- The cosmic uniqueness principle. The world is necessarily unique. The cosmic form principle. The world is an ordered, structured unity. As such, the world has a form. The possibility of multiple instantiation principle. For all F, if F is a form, it is possible that there exist multiple Fs. In De caelo I.9, Aristotle argues that we can establish the uniqueness of the universe, reject the multiple instantiation principle, yet still retain the distinction between 'this world' and 'world in general,' if the following is true (as it is): the world takes up all the matter that exists. Aristotle illustrates this argument with one of the stranger analogies in his corpus: imagine an aquiline nose that takes up all the flesh in the universe. If this were so, then there could not exist any other aquiline objects whatsoever. (For this reason, we dub the De caelo I.9 argument the 'Cosmic Nose argument.') This paper is an interpretation of how this argument is supposed to proceed and an assessment of its success. The first section states the problem Aristotle is confronted with, sorts through Aristotle's various statements of the Cosmic Nose argument, which exhibit some sloppiness, and reconstructs charitably a single argument. We also spend some time examining the significance of Aristotle's example of a gigantic aquiline nose. We argue that, even charitably reconstructed, the argument appears to commit a serious modal fallacy. The remainder of the paper explores whether this modal fallacy can be overcome. We conclude that, although not a cogent argument for the uniqueness of the world (as this would require a significant revision of our current astronomy), the Cosmic Nose argument does succeed on its own terms. However, it should not be regarded as a free-standing argument for the uniqueness of the world. Instead, it depends crucially on the earlier argument in De caelo I.8 for the universe's uniqueness; De caelo I.9 should be viewed as an attempt to extend the conclusion of De caelo I.8 and to show how this conclusion can be made consistent with Aristotle's metaphysical principles about the nature of form. (shrink)

Overview of Epicurean physics and epistemology, ending with a critical discussion of Cicero's report on Epicurean theology.

Titus Lucretius Carus was an ardent disciple of Epicurus and the author of the De Rerum Natura, one of the greatest poems in Latin. Other than his approximate dates of birth and death, we have next to no reliable information about him. Because of his family name and his apparent familiarity with Roman upper-class mores, it is thought that Lucretius was probably a member of the aristocratic clan of the Lucretii, but this is not certain. And so any insight we (...) wish to gain into the thought and personality of Lucretius must come from the De Rerum Natura itself. (shrink)

Brief article on this hedonist, follower of Socrates, and founder of the Cyrenaic school.

Overview of this minor Socratic school, including their skepticism and hedonistic ethics.

Overview of Epicurus' philosophy, including his metaphysics, theory of knowledge, and ethics.

Adorning the Country with Ruins -- The Western Baroque Landscape -- The Irish Tours -- Designing Picturesque Ireland -- Epilogue: Studies in a Point of View.

Major Conservative and Libertarian Thinkers provides comprehensive accounts of the works.

This essay offers a start on sorting out the relationships of argumentation and persuasion by identifying two systematic ways in which definitions of argumentation differ, namely, their descriptions of the ends and of the means involved in argumentative discourse. Against that backdrop, the traditional “conviction-persuasion” distinction is reassessed. The essay argues that the traditional distinction correctly recognizes the difference between the end of influencing attitudes and that of influencing behavior—but that it misanalyzes the means of achieving the latter (by focusing (...) on emotional arousal) and that it mistakenly contrasts “rational” and “emotional” means of influence. The larger conclusion is that understanding the relationships of the phenomena of argumentation and persuasion will require close attention to characterizations of communicative ends and means. (shrink)

Trust is valuable when placed in trustworthy agents and activities, but damaging or costly when placed in untrustworthy agents and activities. So it is puzzling that much contemporary work on trust – such as that based on polling evidence – studies generic attitudes of trust in types of agent, institution or activity in complete abstraction from any account of trustworthiness. Information about others’ generic attitudes of trust or mistrust that take no account of evidence whether those attitudes are well or (...) ill placed can offer little or no help for those who aim to place or refuse trust well. Information about attitudes is evidently useful to those who aim to influence those who hold them, which explains why polls about attitudes are popular with political parties, advertisers and other campaigning organisations. But where we aim not to influence others, but to place and refuse trust intelligently we must link trust to trustworthiness, and must focus on evidence of honesty, competence and r... (shrink)

Contemporary societies are often “polarized”, in the sense that sub-groups within these societies hold stably opposing beliefs, even when there is a fact of the matter. Extant models of polarization do not capture the idea that some beliefs are true and others false. Here we present a model, based on the network epistemology framework of Bala and Goyal, 784–811 1998), in which polarization emerges even though agents gather evidence about their beliefs, and true belief yields a pay-off advantage. As we (...) discuss, these results are especially relevant to polarization in scientific communities, for these reasons. The key mechanism that generates polarization involves treating evidence generated by other agents as uncertain when their beliefs are relatively different from one’s own. (shrink)

For millennia, idleness and laziness have been regarded as vices. We're all expected to work to survive and get ahead, and devoting energy to anything but labor and self-improvement can seem like a luxury or a moral failure. Far from questioning this conventional wisdom, modern philosophers have worked hard to develop new reasons to denigrate idleness. In Idleness, the first book to challenge modern philosophy's portrayal of inactivity, Brian O'Connor argues that the case against an indifference to work and effort (...) is flawed--and that idle aimlessness may instead allow for the highest form of freedom. -/- Idleness explores how some of the most influential modern philosophers drew a direct connection between making the most of our humanity and avoiding laziness. Idleness was dismissed as contrary to the need people have to become autonomous and make whole, integrated beings of themselves (Kant); to be useful (Kant and Hegel); to accept communal norms (Hegel); to contribute to the social good by working (Marx); and to avoid boredom (Schopenhauer and de Beauvoir). -/- O'Connor throws doubt on all these arguments, presenting a sympathetic vision of the inactive and unserious that draws on more productive ideas about idleness, from ancient Greece through Robert Burton's Anatomy of Melancholy, Schiller and Marcuse's thoughts about the importance of play, and recent critiques of the cult of work. A thought-provoking reconsideration of productivity for the twenty-first century, Idleness shows that, from now on, no theory of what it means to have a free mind can exclude idleness from the conversation. (shrink)

Biomedical diagnostic science is a great deal less successful than we've been willing to acknowledge in bioethics, and this fact has far-reaching ethical implications. In this article I consider the surprising prevalence of medically unexplained symptoms, and the term's ambiguous meaning. Then I frame central questions that remain answered in this context with respect to informed consent, autonomy, and truth-telling. Finally, I show that while considerable attention in this area is given to making sure not to provide biological care to (...) patients without a need, comparatively little is given to the competing, ethically central task of making sure never to obstruct access to biological care for those with diagnostically confusing biological conditions. I suggest this problem arises from confusion about the philosophical value of vagueness when it comes to the line between biological and psychosocial needs. (shrink)

In this study, we propose and test a model of the effects of organizational ethical culture and organizational architecture on the perceived unethical behavior of employees towards customers. This study also examines the relationship between organizational ethical culture and moral acceptability judgment, hypothesizing that moral acceptability judgment is an important stage in the ethical decision-making process. Based on a field study in one of the largest financial institutions in Europe, we found that organizational ethical culture was significantly related to the (...) perceived frequency of unethical behavior towards customers and to the moral acceptability judgment of this type of unethical behavior. No support was found for the claim that features of organizational architecture are associated with the perceived frequency of unethical behavior towards customers. This is the first study to document the differential effects of organizational architecture and organizational ethical culture on perceived unethical behavior of employees towards customers, in wholesale banking. Implications for managers and future research are discussed. (shrink)

1. Kodae ch'ŏrhak sasang -- 2. Chungse ch'ŏrhak sasang 1 (Se nara sigi wa Parhae mit hugi Silla sigi) -- 3. Chungse ch'ŏrhak sasang 2 (Koryŏ sigi) -- 4. Chungse ch'ŏrhak sasang 3 (Yijo chŏnban'gi) -- 5. Chungse ch'ŏrhak sasang 4 (Yijo hugan'gi) -- 6. Chungse ch'ŏrhak sasang 5 (Yijo hugan'gi) -- 7. Kŭndae ch'ŏrhak sasang 1 -- 8. Kŭndae ch'ŏrhak sasang 2 -- 9. Puryo pulgul ŭi hyŏngmyŏng t'usa Kim Hyŏng-jik Sŏnsaengnim ŭi ch'ŏrhak sasang -- 10. Widaehan suryŏng Kim (...) Il-sŏng Tongji ŭi ch'ŏrhak sasang 1 -- 11. Widaehan suryŏng Kim Il-sŏng Tongji ŭi ch'ŏrhak sasang 2 -- 12. Widaehan suryŏng Kim Il-sŏng Tongji ŭi ch'ŏrhak sasang 3 -- 13. Widaehan yŏngdoja Kim Chŏng-il Tongji ŭi ch'ŏrhak sasang 1 -- 14. Widaehan yŏngdoja Kim Chŏng-il Tongji ŭi ch'ŏrhak sasang 2 -- 15. Widaehan yŏngdoja Kim Chŏng-il Tongji ŭi ch'ŏrhak sasang 3. (shrink)

Over the past several decades, a large number of publications have claimed that there are important similarities between mindfulness and phenomenology, with a particular emphasis on the epoché and phenomenological reduction. We argue that these comparisons trade on a rather superficial and often misleading presentation of phenomenology. The epoché-reduction is treated either as a matter of bracketing our 'theoretical baggage' so as to allow for a full disclosure and precise description of the objects of experience, or as a matter of (...) bracketing our preoccupation with and absorption in worldly affairs so as to allow for a close attention to subjective acts. Both interpretations mischaracterize the proper scope of phenomenology, namely the subject-object (mind-world) correlation. Furthermore, both miss the theoretical, systematic, and (most importantly) philosophical character of phenomenology. We suggest that, in the end, comparisons between phenomenology and Buddhism would be better off focusing on Buddhist philosophy, rather than Buddhist meditative practice. (shrink)

Intersectionality theory explores the special sorts of disadvantage that arise as the result of occupying multiple disadvantaged demographic categories. One significant methodological problem for the quantitative study of intersectionality is the difficulty of acquiring data sets large enough to produce significant results when one is looking for intersectional effects. For this reason, we argue, simulation methods may be particularly useful to this branch of theorizing because they can generate precise predictions and causal dependencies in a relatively cheap way, and can (...) thus guide future empirical work. We illustrate this point through models which show that intersectional oppression can arise under conditions where social groups are disadvantaged in the emergence of bargaining norms. As we show, intersectional disadvantage can arise even when actors from all social categories are completely identical in terms of preferences and abilities. The conditions necessary to derive such disadvantage are relatively minimal. And when actors behave in ways that reflect stronger intersectional identities, the potential for disadvantage increases. (shrink)

Philosophical theories of emotions, and to an extent some theories of scientific psychology, represent attempts to capture the essence of emotions basically as they are conceived in common sense psychology. Although there are problems, the success of explanations of our behavior in terms of believes, desires and emotions creates a presumption that, at some level of abstraction, they reflect important elements in our psychological nature. It is incumbent on a theory of emotions to provide an account of two salient facts (...) about emotions as conceived in common sense psychology. As intentional states, emotions have representational and rational properties: emotions represent states of affairs; and they are rationally related to other mental representations, figure in rational explanations of behavior, and are open to rational assessment. Emotions also have a close relationship to a range of non-intentional phenomena: in typical cases, emotions involve physiological changes, usually associated with the activation of the autonomic nervous system, which are proprioceptively experienced; and they often involve behavioral tendencies, as well. (shrink)

Building on Alfred Schütz’s work, this essay conceptually scrutinizes virtual worlds with an aim to clarify what is at stake with the virtualization of the late modern society. The diffusion of technological artifacts, devices of communication and the Internet in particular, have transformed the life-world of essentially everyone. In the past few years our everyday life, including its livelihoods, has seen a proliferation of activities within virtual worlds, such as games and virtual social networks. We can now live and experience (...) actively in different virtual realms, as compared to being mere passive receivers in the era of television and radio. This has direct implications for what is inherently relevant for people and, in consequence, we have to take such transformation into account also in conceptual terms. This article makes a major contribution to the conceptual understanding of phenomenological sociology that due to the virtualization, we can no more equate the paramount reality as the zone of primary relevance. The paramount reality as conceived as the sensorily perceivable, physical world of concrete objects is increasingly far from being equated to that part of the world within our reach which we can immediately observe and also at least partially dominate, that is, the zone of primary relevance. It is furthermore argued that the ongoing virtualization of societies urges us to conceive of virtual worlds as transforming the chief finite province of meaning, that of the world of working, instead of seeing virtual worlds merely as other sub-universes of reality. (shrink)

Why do minority groups tend to be discriminated against when it comes to situations of bargaining and resource division? In this paper, I explore an explanation for this disadvantage that appeals solely to the dynamics of social interaction between minority and majority groups---the cultural Red King effect. As I show, in agent-based models of bargaining between groups, the minority group will tend to get less as a direct result of the fact that they frequently interact with majority group members, while (...) majority group members meet them only rarely. This effect is strengthened by certain psychological phenomenon---risk aversion and in-group preference---is robust on network models, and is strengthened in cases where pre-existing norms are discriminatory. I will also discuss how this effect unifies previous results on the impacts of institutional memory on bargaining between groups. (shrink)

Beyond Vision brings together eight essays by Casey O'Callaghan which draw theoretical and philosophical lessons about perception, the nature of its objects, and sensory awareness. O'Callaghan focuses on auditory perception, perception of spoken language, and multisensory perception.

This introduction outlines the importance that Hans-Georg Backhaus’s transcript of Adorno’s 1962 seminar on ‘Marx and the Basic Concepts of Sociological Theory’ has for shedding light on the relationship between Adorno’s critical theory and the critique of political economy. PartIsignals the importance of the seminar by assaying the Anglophone scholarship on Adorno. PartIIcontextualises the seminar in the development of his thought. PartsIIIandIVfocus on what the transcript tells us about Adorno’s interpretation of Marx and the importance this interpretation held for Adorno’s (...) critical social theory. PartVpoints to the influence this interpretation of the critique of political economy had on the formation of the New German Reading of Marx. (shrink)

In this paper I want to propose that we see solipsism as arising from certain problems we have about identifying ourselves as subjects in an objective world. The discussion will centre on Wittgenstein’s treatment of solipsism in his Tractatus Logico- Philosophicus. In that work Wittgenstein can be seen to express an unusually profound understanding of the problems faced in trying to give an account of how we, who are subjects, identify ourselves as objects in the world. We have in his (...) compressed remarks, the kernels of a number of arguments which all come together to form what can be called the problem of self-identification. I want to argue that the solipsism of the Tractatus arises at least in part as a solution to, or – to put it less optimistically – as a symptom or articulation of this problem. In approaching Wittgenstein’s early discussion of solipsism in this way I will obviously be in disagreement with some other interpretations of the work. For example, there are those who think that there is no ‘solipsism of the Tractatus’.1 In fact, the Tractarian arguments presented below as motivating solipsism have been seen as fulfilling the quite opposite function of refuting it. I do not intend in this piece to engage with alternative interpretations. Let me say a little bit about why I have granted myself the licence not to do so. First, the focus of my concern with solipsism is on how it connects with what I have called the problem of self-identification. While it is a concern that emerged in an attempt to make sense of Wittgenstein’s remarks in. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Adoro Te Devote of St. Thomas AquinasSr. Lucia Marie of the Visitation Langford O.P.The Adoro te devote is perhaps the most well-beloved Eucharistic hymn of our time, popularly attributed to St. Thomas Aquinas, the medieval Dominican friar known for his theological treatises as well as his Eucharistic hymnography. Unlike most of Aquinas's work, the poem reveals the intensely personal side of his faith. Rich in theological content and (...) inspiring deep Eucharistic devotion, this poem amply repays a closer investigation. We will look first at the questions of authorship, background, and structure before moving on to a discussion of the text itself.The "Disputed Question" of AuthorshipWhile the Adoro te has traditionally been attributed to St. Thomas Aquinas, the Thomistic authorship of the text was contested in the twentieth century, with two main objections being raised. The first claims that the content of the poem contradicts Thomas's own teachings and cannot have flowed from the same pen. The second objection is historical, claiming that a lack of evidence makes Thomistic authorship improbable.The first objection, claiming that the content of the poem is irreconcilable with Thomistic authorship, takes objection to a line in the poem which seems to claim that sense perception is unreliable and inaccurate, at least with regard to the Eucharist. The text of the Adoro te uses the word fallitur (deceived) with reference to the senses: "Visus, tactus, gustus in te fallitur"—"Sight, touch, taste in you are deceived." Some scholars have claimed that this line contradicts the teaching of Aquinas that the senses are [End Page 365] infallible in regard to their proper sensibles.1 Robert Wielockx addresses this charge in his study of the Adoro te, arguing that "the text does not contradict the continuous teaching of Thomas according to which the senses are not wrong when they judge their proper object, which as far as the Eucharist is concerned, is only the sacramental species."2 The substantial presence of Christ in the Eucharist is a mystery which is not knowable by the senses, and as Paul Murray, O.P., observes: "That's surely the point St. Thomas is making."3 However, the Thomistic insistence that all knowledge comes through our senses is not missing even here. While sight, touch, and taste fall short of comprehending the truth before them, the Adoro te itself proclaims that it is another sense—hearing—which reveals the mystery: "sed auditu solo tute creditur"—"but by hearing alone it is safely believed."4Thus there is no solid objection to Thomistic authorship based on the poem's content. But what about the historical evidence? Dom André Wilmart published a comprehensive study of the manuscript tradition in 1929. Noting that there were no extant copies of the text dating to Aquinas's lifetime and that the biography of Aquinas written by his own Dominican confrere and contemporary, William of Tocco, made no mention of the Adoro te, he considered it most probable that the poem was authored at a later date and ascribed to Aquinas.5However, Dom Wilmart did not know that he was not working with William of Tocco's final version of his work. The publication of a critical edition of William of Tocco's Ystoria Sancti Thome de Aquino in 1996 demonstrated that Tocco published his work in four successive redactions. The fourth and final version of his text (unknown to Dom Wilmart) was finished just before his death in 1323, and in this final version, Tocco includes the text of the Adoro te, attributing its authorship to St. Thomas.6 [End Page 366] Furthermore, Wielockx published a study of the Adoro te in 1998; his investigation of the manuscript tradition found that, of fifty-one sources, forty-four explicitly cite St. Thomas as their author. The remaining sources simply lacked any attribution. We may thus conclude with Wielockx: "External evidence, which must be given priority in sound criticism, wholly favors Thomas Aquinas's authorship of the poem."7BackgroundWith the attribution of the poem to St. Thomas Aquinas on secure footing, we now move to the background of the poem. Unlike Aquinas's Eucharistic hymns such as... (shrink)

It is common to regard love, friendship, and other associational ties to others as an important part of a happy or flourishing life. This would be easy enough to understand if we focused on friendships based on pleasure, or associations, such as business partnerships, predicated on mutual advantage. For then we could understand in a straightforward way how these interpersonal relationships would be valuable for someone involved in such relationships just insofar as they caused her pleasure or causally promoted her (...) own independent interests. But many who regard love, friendship, and other associational ties as an important part of a happy or flourishing life suppose that in many sorts of associations—especially intimate associations—the proper attitude among associates is concern for the other for the other's own sake, not just for the pleasure or benefits one can extract from one's associates. It is fairly clear how having friends of this sort is beneficial. What is less clear is how being a friend of this sort might contribute to one's own happiness or well-being. Even if we can explain this, it looks as if the contribution that friendship makes to one's happiness could not be the reason one has to care for friends, for that would seem to make one's concern for others instrumental, not a concern for the other for her own sake. (shrink)

This article challenges the individualism and neutrality of modern moral conscience. It looks to the history of the concept to excavate an older tradition that takes conscience to be social and morally responsive, while arguing that dominant contemporary justifications of conscience in terms of integrity are inadequate without reintroducing these social and moral traits. This prompts a rethinking of the nature and value of conscience: first, by demonstrating that a morally-responsive conscience is neither a contradiction in terms nor a political (...) absurdity; second, by suggesting how a morally-responsive conscience can be informed by the social world without being a mere proxy for social power or moribund tradition. (shrink)

Consequentialism is often criticized for failing to accommodate impersonal constraints and personal options. A common consequentialist response is to acknowledge the anticonsequentialist intuitions but to argue either that the consequentialist can, after all, accommodate the allegedly recalcitrant intuitions or that, where accommodation is impossible, the recalcitrant intuition can be dismissed for want of an adequate philosophical rationale. Whereas these consequentialist responses have some plausibility, associational duties represent a somewhat different challenge to consequentialism, inasmuch as they embody neither impersonal constraints nor (...) personal options, but rather personal constraints. Our intuitions about associational duties resist capture within the intellectual net of consequentialism, and such duties do admit of a philosophical rationale at least as plausible as anything the consequentialist has to offer. (shrink)

. Early microbiome research found numerous associations between microbial community patterns and host physiological states. These findings hinted at community-level explanations. “Top-down” experiments, working with whole communities, strengthened these explanatory expectations. Now, “bottom-up” mechanism-seeking approaches are dissecting communities to focus on specific microbes carrying out particular biochemical activities. To understand the interplay between methodological and explanatory scales, we examine claims of “dysbiosis,” when host illness is proposed as the consequence of a community state. Our analysis concludes with general observations about (...) how methodologies relate to explanations, and the implications for microbiome research. (shrink)

Appeals to nature are ubiquitous in Epicurean ethics and politics. The foundation of Epicurean ethics is its claim that pleasure is the sole intrinsic good and pain the sole intrinsic evil, and this is supposedly shown by the behavior of infants who have not yet been corrupted, "when nature's judgement is pure and whole." Central to their recommendations about how to attain pleasure is their division between types of desires: the natural and necessary ones, the natural but non-necessary ones, and (...) the vain and empty ones. Elsewhere, the Epicureans talk about the "natural goods" of political power and fame, and they contrast "natural wealth" with wealth as "defined by empty opinion." Finally, in their politics, Epicurus claims that the "the justice of nature is a pledge of reciprocal usefulness, [i.e.,] neither to harm one another nor to be harmed." This paper explores two questions regarding these various appeals to nature. The first is: what is it for these things to be natural, i.e., what notion of "natural" or "nature" is at play here? (Furthermore, is there a single notion being used across these appeals, and if not, how are they related?) The second is: what normative work does a thing's being natural do? That is, what reason, if any, does a desire's being natural give me for pursuing the object of that desire and trying to fulfill that desire, as opposed to not doing so and trying to eliminate it, and similarly for the other appeals to nature? (shrink)

Obesity is the focus of multiple lines of inquiry that have -- together and separately -- produced many deep insights into the physiology of weight gain and maintenance. We examine three such streams of research and show how they are oriented to obesity intervention through multilevel integrated approaches. The first research programme is concerned with the genetics and biochemistry of fat production, and it links metabolism, physiology, endocrinology and neurochemistry. The second account of obesity is developmental and draws together epigenetic (...) and environmental explanations that can be embedded in an evolutionary framework. The third line of research focuses on the role of gut microbes in the production of obesity, and how microbial activities interact with host genetics, development and metabolism. These interwoven explanatory strategies are driven by an orientation to intervention, both for experimental and therapeutic outcomes. We connect the integrative and intervention-oriented aspects of obesity research through a discussion of translation, broadening the concept to capture the dynamic, iterative processes of scientific practice and therapy development. This system-oriented analysis of obesity research expands the philosophical scrutiny of contemporary developments in the biosciences and biomedicine, and has the potential to enrich philosophy of science and medicine. (shrink)