Dopamine is critically important in the neural manifestation of motivated behavior, and alterations in the human dopaminergic system have been implicated in the etiology of motivation-related psychiatric disorders, most prominently addiction. Patients with chronic addiction exhibit reduced dopamine D2 receptor (DRD2) availability in the striatum, and the DRD2 TaqIA (rs1800497) and C957T (rs6277) genetic polymorphisms have previously been linked to individual differences in striatal dopamine metabolism and clinical risk for alcohol and nicotine dependence. Here, we investigated the hypothesis that the (...) variants of these polymorphisms would show increased reward-related memory formation, which has previously been shown to jointly engage the mesolimbic dopaminergic system and the hippocampus, as a potential intermediate phenotype for addiction memory. To this end, we performed functional magnetic resonance imaging (fMRI) in 62 young, healthy individuals genotyped for DRD2 TaqIA and C957T variants. Participants performed an incentive delay task, followed by a recognition memory task 24 h later. We observed effects of both genotypes on the overall recognition performance with carriers of low-expressing variants, namely TaqIA A1 carriers and C957T C homozygotes, showing better performance than the other genotype groups. In addition to the better memory performance, C957T C homozygotes also exhibited a response bias for cues predicting monetary reward. At the neural level, the C957T polymorphism was associated with a genotype-related modulation of right hippocampal and striatal fMRI responses predictive of subsequent recognition confidence for reward-predicting items. Our results indicate that genetic variations associated with DRD2 expression affect explicit memory, specifically for rewarded stimuli. We suggest that the relatively better memory for rewarded stimuli in carriers of low-expressing DRD2 variants may reflect an intermediate phenotype of addiction memory. (shrink)

Subjects and Simulations presents essays focused on suffering and sublimity, representation and subjectivity, and the relation of truth and appearance through engagement with the legacies of Jean Baudrillard and Philippe Lacoue-Labarthe.

In this essay, Robin May Schott criticizes leading proponents of just war theory and introduces the notion of justifiable but illegitimate violence. Instead of legitimating some wars as just, it is better to acknowledge that both the situation of war and moral judgments about war are ambiguous. Schott raises the questions: What are alternative narratives of war? And what are alternative narratives to war? Such narratives are necessary for addressing the concepts of evil and of witnessing in the (...) ethical discourse after Auschwitz. (shrink)

[I]f you could know a priori that you are in a given mental state, and your being in that state conceptually or logically implies the existence of external objects, then you could know a priori that the external world exists. Since you obviously _can.

This essay examines Claudia Card's notion of misplaced gratitude, which she explores in one of her last papers, “Gratitude to the Decent Rescuer.” Whereas typically philosophers have been interested in the problems of the failures to honor obligations of gratitude, Card is more interested in the opposite fault of misplaced gratitude. Her interest reflects her social indignation and her fundamental commitment to opposing oppression, exploitation, and injustice in all its forms. The phenomenon of misplaced gratitude becomes visible from this perspective, (...) where one catches sight of what oppression does to people. The essay looks at the question, What does Card's analysis of misplaced gratitude tell us about her own philosophical methods and contributions? It discusses her engagement with both care ethics and Beauvoir's phenomenology of oppression to clarify the centrality of misplaced gratitude for Card's work in developing an ethics of oppression. (shrink)

The phenomenon of misplaced gratitude becomes visible from this perspective, where one catches sight of what oppression does to people. Only then can one see that if, for example, a woman is grateful for not being battered by her husband, her gratitude is misplaced because it is based on socially normative beliefs and practices that in themselves undermine the possibility of justice and moral integrity. One finds the problem of misplaced gratitude on the edges of Claudia Card's scathing and brilliant (...) critique of feminist care ethics as a form of slave morality. One of Card's achievements was to sustain a passionate engagement with issues of oppression coupled with close philosophical scrutiny. Care ethics risks including too much—as in the risk of caring for abusers. Misplaced gratitude is also dangerous because of its tendency to bind one to the abuser, and thereby to make one become complicit in one's own abuse. (shrink)

In this article I discuss Claudia Card's treatment of war rape in relation to her discussion of the victim's moral power of forgiveness. I argue that her analysis of the victim's power to withhold forgiveness overlooks the paradoxical structure of witnessing, which implies that there is an ungraspable dimension of atrocity. In relation to this ungraspable element, the proposal that victims of atrocity have the power to either offer or withhold forgiveness may have little relevance.

Heidegger in America explores the surprising legacy of his life and thought in the United States of America. As a critic of modern life, Heidegger often lamented the growing global influence of all things American. However, it was precisely in America where his thought inspired the work of generations of thinkers – not only philosophers but also theologians, architects, novelists, and even pundits. As a result, the reception and dissemination of Heidegger's philosophical writings transformed the intellectual and cultural history of (...) the United States at a time when American influence was itself transforming the world. A case study in the complex and sometimes contradictory process of transnational exchange, Heidegger in America recasts the scope and methods of contemporary intellectual and cultural history in the age of globalization, challenging what we think we know about Heidegger and American ideas simultaneously. (shrink)

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The discussion of collective agency involves the reduction problem of the concept of a collective. Individualism and Cartesian internalism have long restricted orthodox theories and made them face the tension between an irreducible concept of a collective and ontological reductionism. Heterodox theories as functionalism and interpretationism reinterpret the concept of agency and accept it as realized on the level of a collective. In order to adequately explain social phenomena that have relations as their essence, in this paper we propose a (...) relational, holistic account of collective agency and argue that functionalism and interpretationism can be integrated into such an account. (shrink)

The reliability of clinical practice guidelines has been disputed because guideline panel members are often burdened with financial conflicts of interest. Current recommendations for COI regulation advise not only detailed declaration but also active management of conflicts. To continuously assess COI declaration and management in German guidelines we established the public database LeitlinienWatch. We analyzed all German guidelines at the highest methodological level that included recommendations for pharmacological therapy according to five criteria: declaration and assessment of COI, composition of the (...) guideline development group, independence of the coordinators and lead authors, imposed abstentions because of COI and public external review. Each criterion was assessed using predefined outcome categories. Most guidelines contained a detailed declaration of COI. However, none of the guidelines provided full transparency of COI assessment results. The guideline group was composed of a majority of participants with COI in 55% of the guidelines, no guideline was free of participants with COI. Only 9% of guidelines had coordinators and lead authors without any financial COI. Most guidelines did not provide a rule for abstentions for participants with COI. In 21% of guidelines there was a rule, but abstentions were either not practiced or not documented, whereas in 7% partial abstentions and in 2% complete abstentions were documented. Two thirds of the guideline drafts were not externally reviewed via a public website. COI are usually documented in detail in German guidelines of the highest methodological level. However, considerable improvement is needed regarding active management of COI, including recruitment of independent experts for guideline projects, abstention from voting for participants with COI and external review of the guideline draft. We assume that the publicly available ratings on GuidelineWatch will improve the handling of conflicts of interest in guideline development. (shrink)

In the wake of the Supreme Court Decision, Dobbs v. Jackson Women’s Health Organization, Minkoff, Vullikanti, and Marshall (2024) argue that the unraveling of the constitutional right to abortion t...

Waking hallucinations suggest mechanisms of dream initiation and maintenance. Visual association cortex activation, yielding poorly attended-to, visually ambiguous dream environments, suggests conditions favoring hallucinosis. Attentional and visual systems, coactivated during sleep, may generate imagery that is inserted into virtual environments. Internally consistent dreaming may evolve from successive, contextually evoked images. Fluctuating arousal and context-evoked imagery may help explain dream features.

Nielsen's concept of “covert REM sleep” accounts for more of the complexity in sleep psychophysiology than its conceptual predecessors such as the tonic-phasic model. With new neuroimaging findings, such concepts lead to more precise sleep psychophysiology including both traditional polysomnographic signs and neuronal activity in greater proximity to the actual point sources and distributed networks which generate dreaming. [Hobson et al.; Nielsen].

Sleep researchers in different disciplines disagree about how fully dreaming can be explained in terms of brain physiology. Debate has focused on whether REM sleep dreaming is qualitatively different from nonREM (NREM) sleep and waking. A review of psychophysiological studies shows clear quantitative differences between REM and NREM mentation and between REM and waking mentation. Recent neuroimaging and neurophysiological studies also differentiate REM, NREM, and waking in features with phenomenological implications. Both evidence and theory suggest that there are isomorphisms between (...) the phenomenology and the physiology of dreams. We present a three-dimensional model with specific examples from normally and abnormally changing conscious states. Key Words: consciousness; dreaming; neuroimaging; neuromodulation; NREM; phenomenology; qualia; REM; sleep. (shrink)

Sleep researchers in different disciplines disagree about how fully dreaming can be explained in terms of brain physiology. Debate has focused on whether REM sleep dreaming is qualitatively different from nonREM (NREM) sleep and waking. A review of psychophysiological studies shows clear quantitative differences between REM and NREM mentation and between REM and waking mentation. Recent neuroimaging and neurophysiological studies also differentiate REM, NREM, and waking in features with phenomenological implications. Both evidence and theory suggest that there are isomorphisms between (...) the phenomenology and the physiology of dreams. We present a three-dimensional model with specific examples from normally and abnormally changing conscious states. Key Words: consciousness; dreaming; neuroimaging; neuromodulation; NREM; phenomenology; qualia; REM; sleep. (shrink)

I defend a new reading of Spinoza's account of causation that reconciles the strengths of the mechanist and formal cause interpretations by locating instances of nature's fixed and unchanging laws inside individual natures; natures are efficacious because that's where the laws are. God's necessity, for instance, follows from certain logical principles contained within God's nature. Causes between finite particulars likewise stem entirely from finite natures. They do so, I argue, because finite instances of nature's fixed and unchanging laws are inscribed (...) within those natures. In each of these instances, effects follow from natures on account of laws contained within them. (shrink)

Moral luck is a puzzling aspect of our psychology: Why do we punish outcomes that were not intended (i.e. accidents)? Prevailing psychological accounts of moral luck characterize it as an accident or error, stemming either from a re‐evaluation of the agent's mental state or from negative affect aroused by the bad outcome itself. While these models have strong evidence in their favor, neither can account for the unique influence of accidental outcomes on punishment judgments, compared with other categories of moral (...) judgment. Why might punishment be particularly sensitive to moral luck? We suggest that such sensitivity is easily understood from the broader perspective of punishment's ultimate adaptive goal: Changing others’ behavior by exploiting their capacity to learn. This pedagogical perspective accounts for the exceptional influence of outcomes on punitive sentiments and makes predictions for additional moderators of punishment. We review evidence supporting the pedagogical hypothesis of punishment and discuss fruitful directions for future research. (shrink)

Bergson was a pre-eminent European philosopher of the early twentieth century and his work covers all major branches of philosophy. This volume of essays is the first collection in twenty years in English to address the whole of Bergson's philosophy, including his metaphysics, epistemology, philosophy of science, philosophy of life, aesthetics, ethics, social and political thought, and religion. The essays explore Bergson's influence on a number of different fields, and also extend his thought to pressing issues of our time, including (...) philosophy as a way of life, inclusion and exclusion in politics, ecology, the philosophy of race and discrimination, and religion and its enduring appeal. The volume will be valuable for all who are interested in this important thinker and his continuing relevance. (shrink)

Definitions of dreaming are not required to map formal features of mental activity onto brain measures. While dreaming occurs during all stages of sleep, intense dreaming is largely confined to REM. Forebrain structures and many neurotransmitters can contribute to sleep and dreaming without negating brainstem and aminergic-cholinergic control mechanisms. Reductionism is essential to science and AIM has considerable heuristic value. Recent findings support sleep's role in learning and memory. Emerging technologies may address long-standing issues in sleep and dream research.

In this lively collection ten philosophers tackle the notoriously elusive issues raised by religious discourse in a series of linked debates. The debates focus on reason and faith; the logic of mysticism; the meaning of the word 'God'; language, biblical interpretation and worship; and religion and ethics. Through contemporary philosophical analysis it is possible to shed new light on teh status and language of religion, and in many ways the contributors to Religion and Philosophy break new ground in this perennially (...) controversial field. The collection is addressed to philosophers, theologians and anyone with a general intellectual interest in religion. Certainly it will be a valuable addition to the reading list of all teachers or students of the philosophy of religion. (shrink)

Activity in the prefrontal cortex may distinguish the meta-awareness experienced during lucid dreams from its absence in normal dreams. To examine a possible relationship between dream lucidity and prefrontal task performance, we carried out a prospective study in 28 high school students. Participants performed the Wisconsin Card Sort and Iowa Gambling tasks, then for 1 week kept dream journals and reported sleep quality and lucidity-related dream characteristics. Participants who exhibited a greater degree of lucidity performed significantly better on the task (...) that engages the ventromedial prefrontal cortex, but degree of lucidity achieved did not distinguish performance on the task that engages the dorsolateral prefrontal cortex, nor did it distinguish self-reported sleep quality or baseline characteristics. The association between performance on the Iowa Gambling Task and lucidity suggests a connection between lucid dreaming and ventromedial prefrontal function. (shrink)

Based on a comparison of various sources, such as different editions, correspondence, reviews, and lecture transcripts, it is shown that Ludwig Heinrich Jakob’s Outline of the General Logic and Critical Elements of Metaphysics in General uses one or more transcripts of Kant’s Logic Lectures as a source. In addition to the thus far known texts by Kiesewetter and Hippel, Jakob’s textbook should therefore also be added to the list of secondary transmissions of Kant’s Logic Lectures.

Preterm birth is defined as delivery occurring before 37 weeks gestation.1 Infants born prematurely have increased risks of morbidity and mortality throughout life, especially during the first year. These risks increase as the gestational age at birth decreases.2 Additionally, there are significant racial and ethnic differences in preterm birth rates. In 2022, the rate of preterm birth among non-Hispanic black women was approximately 50% higher than that observed in non-Hispanic white women.1 The outcomes for these infants are also disparate–preterm birth (...) and low birth weight are the second-leading causes of infant mortality (deaths before 1 year of age). Notably, among preterm neonates, infants born to non-Hispanic black women have a mortality rate more than double that of infants born to non-Hispanic white mothers.3 Importantly, there is a small but significant group of neonates that can be classified as severely premature (those born <28 weeks). Infants born before 28 weeks have varied and uncertain outcomes. While this group accounts for only 0.4% of preterm births, it also accounts for 40% of deaths among preterm neonates.4 As noted by Romanis and Adkins, the advent of artificial amnion and placenta technology (AAPT) holds promise for its potential to address the physiologic complications and mortality risks of extreme prematurity by introducing amniotic substitutes that mimic in vivo placental oxygenation and substrate delivery. In contrast …. (shrink)

The chapter presents Bergson’s conception of philosophy as a way of life, as a thinking that seeks to make contact with the creativity of life as a whole. This endeavor to alter our vision of the world, and ultimately, our action and sense of being in the world, seeks to operate a “conversion of attention.” For Bergson, such a conversion is tied in with what he calls the “true empiricism” that allows us to experience and think change as that which (...) makes up living reality as a whole. Bergson conceptualizes this move beyond the human in terms of sympathy, a term employed both descriptively, to develop the notion of a sympathetic whole of life in which philosophy as a way of life resituates the self, and prescriptively, as urging us to overcome our estrangement from “the ocean of life” to which we owe our existence. This effort of sympathy takes the form of a spiritual exercise. Not limited to mere contemplation of the world, it transforms the manner in which we perceive the reality of duration and thus opens the path for a different way of living. (shrink)

In the dissertation I examine the split between cognition and eros in Kant's notion of objectivity, which has become paradigmatic for modern theories about knowledge. I argue that the split between cognition, on the one hand, and feelings and desires, on the other, does not capture the necessary conditions of knowledge, as Kant claims, but involves a suppression of erotic factors of existence. ;The split between pure knowledge and sensual existence in Kant's thought reflects an ascetic tradition inherited from both (...) Greek and Christian sources, which views the body, sexuality, and in particular women's sexuality as a source of pollution. According to this tradition, since thought must be divested of the pollution of sensuous existence, women's sexuality precludes them from rational activity. Consequently, the philosophical commitment to purity has justified the exclusion of women from the practice of knowledge. ;The particular form of asceticism which is evident in Kant's treatment of sensibility of objective knowledge, of morality, and of aesthetic judgement, reflects the reified nature of relations in an emerging capitalist economy. The suppression of the immediate, sensual qualities in both the subject and object of knowledge, in Kant's system, corresponds to the suppression of the immediate, qualitative features of the subject and object in the process of commodity production. Both persons and things become reduced to a formal abstract equivalence. Kant's notion of objectivity makes normative this objectification of relations between persons and things. ;Thus, the paradigm of objective knowledge is not only damaging to the thinker, who must detach himself from the emotional and sensual facets of existence. It serves as an ideology which has justified the exclusion of women from the pursuit of knowledge, and which more generally legitimates the distorted human relations generated by the world of commodity production. ;By considering Kant's commitment to pure knowledge in the context of the genealogy of the concept of purity, the themes of asceticism and fetishism emerged as mutually illuminating. Implicit in the ascetic denial of sensuality is a dialectic which leads to an objectification of persons and things. Moreover, the fetishism of commodities involves a detachment of erotic interests from persons which results in an obsessive interest in objects. (shrink)

How do people excluded from political life achieve political agency? Through a series of historical events that have been mostly overlooked by political theorists, Martin Breaugh identifies fleeting yet decisive instances of emancipation in which people took it upon themselves to become political subjects. Emerging during the Roman plebs's first secession in 494 BCE, the _plebeian experience_ consists of an underground or unexplored configuration of political strategies to obtain political freedom. The people reject domination through political praxis and concerted (...) action, therefore establishing an alternative form of power. Breaugh's study concludes in the nineteenth century and integrates ideas from sociology, philosophy, history, and political science. Organized around diverse case studies, his work undertakes exercises in political theory to show how concepts provide a different understanding of the meaning of historical events and our political present. _The Plebeian Experience_ describes a recurring phenomenon that clarifies struggles for emancipation throughout history, expanding research into the political agency of the many and shedding light on the richness of radical democratic struggles from ancient Rome to Occupy Wall Street and beyond. (shrink)