Mammalian synthetic biology holds the promise of providing novel therapeutic strategies, and the first success stories are beginning to be reported. Here we focus on the latest generation of mammalian transgene control devices, highlight state‐of‐the‐art synthetic gene network design, and cover prototype therapeutic circuits. These will have an impact on future gene‐ and cell‐based therapies and help bring drug discovery into a new era. The inventory of biological parts that are essential for life on this planet is becoming increasingly complete. (...) The postgenomic era has provided encyclopedic information on gene‐function correlations and systems biology is now delivering comprehensive details on the dynamics of biochemical reaction networks in living organisms. The time has come to reassemble these catalogued items and design new biological devices and systems with novel and useful functionality in a rational and systematic manner. This is the premise of synthetic biology, a constructive systems biology discipline likely to become the life science revolution of the 21st century. (shrink)

A ‘lottery belief’ is a belief that a particular ticket has lost a large, fair lottery, based on nothing more than the odds against it winning. The lottery paradox brings out a tension between the idea that lottery beliefs are justified and the idea that that one can always justifiably believe the deductive consequences of things that one justifiably believes – what is sometimes called the principle of closure. Many philosophers have treated the lottery paradox as an argument against the (...) second idea – but I make a case here that it is the first idea that should be given up. As I shall show, there are a number of independent arguments for denying that lottery beliefs are justified. (shrink)

My concern in this paper is with the claim that knowledge is a mental state – a claim that Williamson places front and centre in Knowledge and Its Limits. While I am not by any means convinced that the claim is false, I do think it carries certain costs that have not been widely appreciated. One source of resistance to this claim derives from internalism about the mental – the view, roughly speaking, that one’s mental states are determined by one’s (...) internal physical state. In order to know that something is the case it is not, in general, enough for one’s internal physical state to be a certain way – the wider world must also be a certain way. If we accept that knowledge is a mental state, we must give up internalism. One might think that this is no cost, since much recent work in the philosophy of mind has, in any case, converged on the view that internalism is false. This thought, though, is too quick. As I will argue here, the claim that knowledge is a mental state would take us to a view much further from internalism than anything philosophers of mind have converged upon. (shrink)

In this paper, I offer reasons for thinking that two prominent sceptical arguments in the literature – the underdetermination-based sceptical argument and the closure-based sceptical argument – are less philosophically interesting than is commonly supposed. The underdetermination-based argument begs the question against a non-sceptic and can be dismissed with little fanfare. The closure-based argument, though perhaps not question-begging per se, does rest upon contentious assumptions that a non-sceptic is under no pressure to accept.

Martin Heidegger was engaged in a continual struggle to find words - new words, both descriptive and analytical - for his radical form of philosophy. This tendency can be traced from Being and Time, where he elaborated an entirely new vocabulary for his ontological enquiry; to Contributions to Philosophy, which saw him committed to a transformation of language; to later essays on poets such as Rilke and Trakl in On the Way to Language. The Writing of Aletheia is the (...) first study to appear in either English or German that provides a full account of Heidegger's language and writing style. Focusing not only on his major philosophical works but also on his lectures, public talks and poetry, this book explores the complex textuality of Heidegger's writing: the elaborate chains of wordplay and neologistic formations; the often oblique, circuitous and regressive exposition of his ideas; the infamous tautologies; the startling modification of grammatical rules and syntax; the idiosyncratic typography of his texts; the rhetorical devices, imagery and symbolism; and the tone and voice of his writing. All of these aspects betray not only his will to structure and his assertiveness but also his ongoing self-questioning and reflectiveness about the ultimate goal of his philosophical quest. (shrink)

This book takes a fresh and interdisciplinary approach to the concept of subsidiarity. While subsidiarity is commonly understood as an organizational principle that assigns competences to the appropriate level within an organization, its application extends beyond politics. This innovative book offers a comprehensive analysis that includes religious and secular perspectives, exploring the relevance of subsidiarity to society, business, law and politics. By bridging the gap between theology, philosophy, political science, law, and history, this volume fills a significant gap in the (...) literature. It reexamines the ideological foundations of subsidiarity within the Catholic social tradition, investigates its practical implications, and questions how it can address the challenges faced by contemporary business environments, particularly issues of social inequity. With a normative and conceptual approach, the book critically reflects on the links between subsidiarity and themes such as responsible business practices, ecological concerns, individual autonomy, and the common good. By exploring the potential of subsidiarity to overcome dichotomies and promote a middle ground between government-based solutions and individual freedom, the volume offers valuable insights and practical solutions. This volume stands out as the first major study dedicated to subsidiarity in society, business, law and politics. Through its multidisciplinary lens, it sheds light on unexplored connections and highlights the role of subsidiarity in fostering ethical and socially responsible behavior. It is an essential resource for researchers, PhD and graduate students, as well as professionals in theology, philosophy, political sciences, law, and history who seek a comprehensive understanding of subsidiarity and its implications for contemporary issues. (shrink)

The Routledge International Handbook of Neuroaesthetics is an authoritative reference work that provides the reader with a wide-ranging introduction to this exciting new scientific discipline. The book brings together leading international academics to offer a well-balanced overview of this burgeoning field while addressing two questions central to the field; how the brain computes aesthetic appreciation for sensory objects, and how is art created and experienced.

A physician and spokesman for the French Ideologues, Pierre-JeanGeorges Cabanis (1757-1808) stands at the crossroads of several influential developments in modern culture--Enlightenment optimism about human perfectibility, the clinical method in medicine, and the formation and adaptation of liberal social ideals in the French Revolution. This first major study of Cabanis in English traces the influences of these developments on his thought and career. Originally published in 1980. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously (...) out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

The National Women's Hospital research scandal saw women being involved in medical research without their knowledge and without the opportunity to make a choice about their participation. The 1988 Cartwright Inquiry into this decades-long study established a template for ethics review in New Zealand. Ethics committees were subsequently established to independently assess the potential benefits as well as risks of research. This book describes the gradual undermining of the independence of New Zealand ethics review and the politicisation of ethics committees (...) between 1988 and 2014. The authors, involved continuously in ethics review matters over the period, have seen substantial change brought about by government in response to another medical research crisis - in Gisborne in the late 1990s - and then between 2008 and 2010 an economic crisis involving foreign pharmaceutical companies. Some New Zealand medical researchers claimed that the ethics review process for clinical trials was too slow and was losing the country its economic advantage. This book traces the changes and the implications for a robust ethics review process in all research environments in New Zealand, especially those affecting Maori. The book includes a set of suggestions and recommendations aimed at enhancing independent ethics review, best practice, and the provision of adequate protection for all citizens. (shrink)

The purpose of this article is to re-examine an ethic of care as the main ethical approach to nursing practice in light of past and present developments in nursing ethics, and to briefly speculate whether or not it will survive within nursing in the future. Overall, it is maintained throughout that the terms ?caring?, ?nursing? and an ?ethic of care? are inextricably linked. This is because, it is argued, professionally focused nursing practices are based predominantly on a well-recognised moral commitment (...) to deliver expert care, and that a care-based ethic is the major factor in the construction and maintenance of these practices. Subsequently, the influences and developments of a caring ethic in nursing are firstly re-examined, and the discussion is supported by evidence from more recent nursing research and theoretical developments. Consideration is given to the philosophical underpinnings of both care theory and caring ethics, and the fundamental importance of caring in nursing, as an interpersonal relationship and as an appropriate ethical response, is made transparent. Finally, an outline of the future possibilities that may affect an ethic of care in nursing is offered. (shrink)

I respond to a challenge raised by Jordan Pascoe: Kant’s conception of obtaining full citizenship through working oneself up necessarily condemns some people to passive citizenship. I argue that we should not focus on work to establish universal full citizenship. Rather, a Universal Basic Income, an income paid regularly to everyone and without conditions, can secure everyone’s full citizenship. Moreover, I argue that such a scheme is more Kantian in nature than hitherto assumed.

Recent developments in Continental philosophy have included the emergence of a school of “speculative realism,” which rejects the human-centered orientation that has long dominated Continental thought. Proponents of speculative realism differ on several issues, but many agree on the need for an object-oriented ontology. Some speculative realists identify realism with materialism, while others accord equal reality to objects that are non-material, even fictional. Several thinkers retain a focus on difference, a well-established theme in Continental thought. This paper looks at speculative (...) realism from the perspective of systems theory. Many of the tenets of speculative realism have long been features of systems metaphysics and are expressed clearly in a systems framework. However, some views of some speculative realists differ substantially from systems theoretic ideas. (shrink)

Der umfassende Prozess der weltweiten Digitalisierung prägt alle gesellschaftlichen Systeme in unterschiedlicher Weise. Wie sehr verändert die Digitalisierung die uns bekannte Welt und die Vulnerabilität des Lebens? Sind die damit verbundenen Transformationen gar wünschenswert und/oder notwendig? In Hinblick auf eine Vergewisserung dessen, was als (unsere) Welt anzusehen ist, bietet sich der Begriff der Lebenswelt im Ausgang von Edmund Husserl an. Demnach ist es eine wirklich anschauliche, wirklich erfahrene und erfahrbare Welt, in der sich unser ganzes Leben praktisch abspielt. Technisierung bedeutet (...) eine Veränderung dieses menschlichen Weltverhältnisses. Husserl attestierte seinerzeit eine Lebensweltvergessenheit, die zu einer Krise Europas und des europäischen Menschentums beitragen würde. Daher setzte er sich für eine Rehabilitierung der Lebenswelt als Sinnesfundament ein. Diese berühmte Diagnose und jene Massnahme sind seit Husserls Tagen immer wieder aufgegriffen worden. Wird die Digitalisierung die Welt in eine komplett künstliche Welt transformieren, die den Zusammenhang von persönlicher Erfahrung, Leiblichkeit, gesellschaftlichen Institutionen und Erscheinungen der Natur aufgekündigt hat? Bevor eine solche Befürchtung geglaubt werden kann, gilt es, grundlegende Muster der Digitalisierung im Hinblick auf ihre lebensweltliche Konkretion zu befragen. Die vorliegende Studie untersucht Prozesse und deren Querverbindungen aus den Bereichen Politik, Wirtschaft, Verkehr, Wissen, Bildung, Literatur, Gesundheit und Erotik. (shrink)

Das Christentum sagt, dass Jesus Christus sowohl wahrer Mensch als auch wahrer Gott war. Doch wie kann das genauer gedacht werden? Das Buch rekonstruiert umfassend, wie Georg Wilhelm Friedrich Hegel und damit einer der einflussreichsten und interessantesten Denker der Moderne diese Frage beantwortet. Anschließend wird Hegels Lösungsansatz aus theologischer wie aus philosophischer Perspektive kritisiert und der Ansatz eines eigenen Vorschlags skizziert. Zuletzt wird der explizite und implizite Umgang mit Hegel in der gegenwärtigen Theologie untersucht.

Originally presented as author's doctoral thesis. Universitèat, Mèunchen, 2011.

This chapter examines the traditional understanding of Horkheimer and Adorno's dialectic of enlightenment (exemplified by Jürgen Habermas and others), arguing that the traditional reading – with its stress on instrumental rationalization and a regressive or self‐destructive history – misses Horkheimer and Adorno's deepest aspirations, which are to offer an argument against a particular conceptualization of human agency (as apperceptive). Stressing instead, that Kant is the central interlocutor, the chapter shows how understanding this Kantian inheritance allows us to bring into focus (...) the radical nature of Horkheimer and Adorno's argument: that it is meant to bring into focus the problematic nature of conceiving human agency as dependent on apperception. In presenting this problem, the chapter shows how the ontogenetic origin of self‐consciousness becomes a crucial issue, and the thought of Sigmund Freud is marshaled both to make this clear and to show how Horkheimer and Adorno's account can benefit from making explicit its potential debt to Freud. (shrink)

The author defends Conciliationism as a response to peer-disagreement in ethics against a prominent objection: if in cases of peer-disagreement we have to move our credences towards those of our dissenting peers, then we have to adopt scepticism in fields where disagreement between peers abounds. For this objection, the case of ethics is particularly worrisome. The author argues that the objection from scepticism is based on a highly idealised notion of an epistemic peer. In cases of disagreement about ethical issues, (...) it is often unknown to us what another person counts as her evidence, since one’s notions of what counts as evidence and what weight to attach to different forms of evidence are impacted by one’s global outlook. Being aware of what an agent considers as evidence requires familiarity with that agent’s global outlook. This introduces two constraints on epistemic peerhood in cases of disagreement about ethics: an epistemic constraint, and a factual constraint. (shrink)

History of aesthetics and philosophy of arts.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

--Prophet mit Marx- und Engelszungen, von M. Walser.--Philosophie zwischen Traum und Apokalypse, von I. Frenzel.--Messianismus und Marxismus, von J. Moltmann.--Ein marxistischer Schelling, von J. Habermas.--Ein Gespräch über ungelöste Aufgaben der sozialistischen Theorie, von E. Bloch und F. Vilmar.--Ein grosser Einzelgänger, von I. Fetscher.--Ernst Blochs Evolution des Marxismus, von W. Maihofer.--Ausgewählte Bibliographie der Schriften über Ernst Bloch, zusammengestellt von R. Kübler (p. 133-[149]).

Reorientation: Leo Strauss in the 1930s seeks to explain the 'change in orientation' that Strauss underwent during a decade of personal and political upheaval. Though he began to garner attention in the 1950s, it was in the 1930s that Strauss made a series of fundamental breakthroughs which enabled him to recover, for the first time since the Middle Ages, the genuine meaning of political philosophy. Despite this being a period of marked output and activity for Strauss, his research in this (...) era remains overlooked. This volume is the first to assemble in one place an examination of Strauss' various publications throughout the decade, providing a comprehensive analysis of his work during the period. It includes, for the first time in English, five newly translated writings of Strauss from 1929-37, brought to life with insight from leading scholars in the field. (shrink)

Pastor and author Martin Thielen has compiled a list of ten things people need to believe, and ten things they don't, in order to be a Christian. This lively and engaging book will be a help to seekers as well as a comfort to believers who may find themselves questioning some of the assumptions they grew up with. With an accessible, storytelling style that's grounded in solid biblical scholarship, Thielen shows how Christians don't need to believe that sinners will (...) be "left behind" to burn in hell or that it's heresy to believe in evolution. And while we must always take the Bible seriously, we don't always have to take it literally. At the same time, Christians do need to believe in Jesus--his life, his teachings, his death and resurrection, and his vision for the world. A great benefit of those beliefs is that they provide promising answers to life's most profound questions, including: Where is God? What matters most? What brings fulfillment? What about suffering? Is there hope? Thielen articulates centrist, mainline Christianity in a way that's fresh and easy to understand, and offers authentic Christian insights that speak to our deepest needs. This new edition includes a leader's guide, previously only available online, and a new introduction from the author that reflects on the book's reception. The leader's guide features unique and easily implemented aids for carrying out a seven-week, congregation-wide initiative that will help local churches reach out to their communities. More information is available at thielen.wjkbooks.com. (shrink)

"Hannah Arendt war der schwierigste Film, den ich je gemacht habe", sagt Margarethe von Trotta. Die grosse Denkerin Hannah Arendt fühlte sich.

In Making Wonderful, Martin M. Tweedale tells how an ideology arose in the West that energized the economic expansion that has led to ecological disaster. He takes us back to the rise of cities and autocratic rulers, and analyzes how respect for custom and tradition gave way to the dominance of top-down rational planning and organization. Then came a highly attractive myth of an eventual future in which all of humankind's material and spiritual ills would be banished and life (...) "made wonderful." Originating in Zoroastrianism and, through Jewish apocalyptic works, flowing into early Christianity, this belief produced utopian ideologies that set the West apart from the other civilizations of the old world. Tweedale shows how this thinking became popular among Western elites in the early modern period and eventually resulted in the distinctively Western doctrine of progress, an idea that once coupled with a virtually religious faith in the capacity of science and technology to improve human life, released economic expansion from traditional constraints. Exploring sources from philosophy, religion, and the history of ideas, Making Wonderful is for all readers who are intellectually curious about the roots of our eco-catastrophe. (shrink)

Das Studienbuch fuhrt in die nordamerikanisch gepragte kognitive Semantik unter Bezugnahme auf kognitiv-anthropologische Aspekte ein. Die vielschichtige Interaktion von Sprache und Kognition wird anhand der Raumlinguistik und Raumkognition exemplarisch dargestellt. Einbezogen werden daneben aktuelle Ergebnisse der Forschung zur Frage nach dem Einfluss von Sprache auf Kognition und damit verkorperungstheoretische wie wahrnehmungsbasierte Ansatze. ".