The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor . Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1 , and the beta amyloid precursor (...) cleaving enzyme . In mice, AbetaPP and SP1 mRNA and their protein products were elevated late in life; Abeta levels declined in old age. In monkeys, SP1, AbetaPP, and BACE1 mRNA declined in old age, while protein products and Abeta levels rose. Proteolytic processing in both species did not match production of Abeta. In primates, AbetaPP and SP1 mRNA levels coordinate, but an inverse relationship exists with corresponding protein products as well as Abeta levels. Comparison of human DNA and mRNA sequences to monkey and mouse counterparts revealed structural features that may explain differences in transcriptional and translational processing. These findings are important for selecting appropriate models for AD and other age-related diseases. (shrink)

Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. (...) The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)

Objective: The objectives of this study are to understand the current functions, structure and operation of hospital ethics committees (HECs) in Shanghai and to facilitate their improvement. Methods: (1) A questionnaire survey, (2) interviews with secretaries and (3) on-site document reviews of HECs in Shanghai were used in the study, which surveyed 33 hospitals. Results: In Shanghai, 57.56% of the surveyed hospitals established HECs from 1998 to 2005. Most HECs used bioethical review of research involving human subjects as well as (...) bioethical review or consultation regarding medical care services and administrative decision- making. Of the surveyed HECs, 14.3% did not provide any formal bioethical training to the HECs’ members and many HECs had no standard operating procedures. Some HECs had no clear definition of what was “conflict of interest” that should be considered by the HECs, while 44.4% of the HECs did not perform continuing review. Discussion: After the issues of related national regulations, more and more hospitals established HECs in Shanghai, but the functions of HECs need to be further developed and formal training on bioethics should be provided to HEC members. To assure the independence and good performance of HECs, the conflict of interest procedure, the standard operating procedures and bioethical review should be improved. Conclusion: HECs in Shanghai had developed in the preceding 10 years and they played great roles in protecting the rights and welfare of human subjects and patients; some areas need improvement. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Books ReceivedThe Ambitions of Curiosity: Understanding the World in Ancient Greece and China. By G.E.R. Lloyd. Cambridge: Cambridge University Press, 2002. Pp. xvi + 175. Price not given.The Art of the Han Essay: Wang Fu's Ch'ien-Fu Lun. By Anne Behnke Kinney. Tempe: Center for Asian Studies, Arizona State University, 1990. Pp. xi + 154. Paper $10.00.The Autobiography of Jamgön Kongtrul: A Gem of Many Colors. By Jamgön Kongtrul Lodrön (...) Thayé and translated by Richard Barron (Chökyi Nyima). Ithaca, New York: Snow Lion Publications, 2003. Pp. xxii + 549. Price not given.Awesome Nightfall: The Life, Times, and Poetry of Saigyō. By William R. LaFleur. Boston: Wisdom Publications, 2003. Pp. xiii + 173. Paper $14.95.Becoming the Compassion Buddha: Tantric Mahamudra for Everyday Life. By Lama Thubten Yeshe, edited by Robina Courtin, and foreword by Geshe Lhundub Sopa. Boston: Wisdom Publications, 2003. Pp. xi + 194. Paper $14.95.Between Two Worlds East and West: An Autobiography. By J. N. Mohanty. New Delhi: Oxford University Press, 2002. Pp. ix + 134. Hardcover RS 525.00.The Chinese Face of Jesus Christ. Edited by Roman Malek, S.V.D. Sankt Augustin, Germany: Institut Monumenta Serica and China-Zentrum; and Nettetal, Germany: Steyler Verlag, 2002. Pp. 391. EUR 40.00.Chinese Medicine in Contemporary China: Plurality and Synthesis. By Volker Scheid. Durham and London: Duke University Press, 2002. Pp. xiv + 407. Hardcover $69.95. Paper $23.95.Confucian Feminist: Memoirs of Zeng Baosun (1893-1978). Translated and adapted by Thomas L. Kennedy. Philadelphia: American Philosophical Society, 2002. Pp. xxi + 170. Price not given.Consciousness Studies: Cross-Cultural Perspectives. By K. Ramakrishna Rao. Jefferson (North Carolina) and London: McFarland and Company, 2002. Pp. 367. Hardcover $65.00.Constituting Communities: Theravāda Buddhism and the Religious Cultures of South and Southeast Asia. Edited by John Clifford Holt, Jacob N. Kinnard, and Jonathan S. Walters. Albany: State University of New York Press, 2003. Pp. viii + 224. Hardcover $65.50. Paper $21.95.Developments in Indian Philosophy from Eighteenth Century Onwards: Classical and Western. By Daya Krishna. Volume X Part 1 of History of Science, Philosophy and Culture in Indian Civilization, edited by D. P. Chattopadhyaya. New [End Page 110] Delhi: Centre for Studies in Civilizations, 2001. Pp. xxiii + 417. Hardcover RS 1200.East and West: Identità e dialogo interculturale. By Giangiorgio Pasqualotto. Venezia: Marsilo Editori, 2003. Pp. 210. EUR 16.00.Effortless Action: Wu-wei as Conceptual Metaphor and Spiritual Ideal in Early China. By Edward Slingerland. New York: Oxford University Press, 2003. Pp. xii + 352. Price not given.Encountering Kā lī: In the Margins, at the Center, in the West. Edited by Rachel Fell McDermott and Jeffrey J. Kripal. Berkeley and Los Angeles: University of California Press, 2003. Pp. xviii + 321. Hardcover $55.00, £37.95. Paper $21.95, £15.95.Encyclopedia of Chinese Philosophy. Edited by Antonio S. Cua. New York and London: Routledge, 2003. Pp. xx + 1020. Hardcover $150.00.Essays on Indian Philosophy. By J. N. Mohanty and edited by Purushottama Bilimoria. New Delhi: Oxford University Press, 2002. Pp. xxxvii + 347. Paper RS 525.00.Faith, Humor, and Paradox. By Ignacio L. Götz. Westport, Connecticut: Praeger Publishers, 2002. Pp. 136. Hardcover $61.95.Four Illusions: Candrakīrti's Advice for Travelers on the Bodhisattva Path. Translated by Karen C. Lang. New York: Oxford University Press, 2003. Pp. xv + 240. Price not given.The Great Awakening: A Buddhist Social Theory. By David R. Loy. Boston: Wisdom Publications, 2003. Pp. 223. Paper $16.95.The Hidden History of The Tibetan Book of the Dead. By Bryan J. Cuevas. New York: Oxford University Press, 2003. Pp. xi + 328. Price not given.Huang Di nei jing su wen: Nature, Knowledge, Imagery in an Ancient Chinese Medical Text. By Paul U. Unschuld. Berkeley and Los Angeles: University of California Press, 2003. Pp. xii + 520. Hardcover $75.00, £52.00.In Dewey's Wake: Unfinished Work of Pragmatic Reconstruction. Edited by William J. Gavin. Albany: State University of New York Press, 2003. Pp. vi + 249. Hardcover $71.50. Paper $23.95.Knowledge and Freedom in Indian Philosophy. By Tara Chatterjea. Lanham, Maryland: Lexington Books, 2002. Pp. xvi + 159. Hardcover... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Interpreting the MengziPhilip J. IvanhoeMencius: Contexts and Interpretations. Edited by Alan K. L. Chan. Honolulu: University of Hawai'i Press, 2002. Pp. vii + 328. Hardcover $51.00.Mencius: Contexts and Interpretations, edited by Alan K. L. Chan, is an important collection of essays from a scholarly conference held at the National University of Singapore in 1999. It begins with a concise yet incisive introduction to Mengzi, his work, and the various (...) contributions to the volume. The essays engage the Mengzi from a wide range of perspectives and employ a variety of different approaches. One of its many virtues is the inclusion of articles that explore the relationship of the text to recently excavated Guodian material. The primary audience of these essays is other scholars. However, several contributions could be understood and appreciated by nonspecialists as well.In the lead essay, Ning Chen criticizes a wide range of current accounts concerning the background of Mengzi's theory of human nature and argues that because of these mistaken impressions about Mengzi's intellectual context contemporary scholars fail to appreciate important features of Mengzi's own theory. Chen argues that in order to understand Mengzi's theory it is necessary to appreciate that he was responding to a heretofore unnoticed Mohist theory of human nature and to views that we find in certain Guodian texts. Both of these sources describe "inegalitarian" theories of human nature, and such theories served as a central focus of not only Mengzi's but Xunzi's theory of human nature as well.Some may find Chen's claims about the Mohist theory of human nature in need of further support. His evidence is a single passage from the later, dialectical chapters and the reading of this passage remains highly controversial. Given the importance of this issue for Mengzi and the significant debates Mengzi has with Mohists in various places in the Mengzi, it is quite strange that we see no direct reference to this theory in the text, nor do we find evidence of it in the core chapters of the Mozi. Chen argues that his interpretation is superior to that of Wu Yujing, who argues that the Mohists advocated the view that human nature was ethically neutral. However, Chen does not mention that others have produced quite impressive arguments in support of this same conclusion, for example David S. Nivison.Chen presents interesting and impressive textual work on Guodian texts and no one can deny that this material adds to our understanding of early Chinese philosophy. However, it is not yet clear how, if at all, these texts change our interpretation of Mengzi's theory itself. Even on the issue of what motivated thinkers like Mengzi [End Page 249] and Xunzi to argue for more "egalitarian" theories, it is not clear that Chen has identified anything strikingly new. While the Guodian texts do describe new and interesting theories concerning the character of human nature, these are not the first "inegalitarian" theories. Perhaps more important, one need not see thinkers like Mengzi as responding only or even primarily to explicit theories about human nature; there was ample motivation to argue for a fundamental moral equality among human beings in order to resist the inertia of hereditary rule. As Donald Munro argued in his classic work, The Concept of Man in Early China, this is a distinctive feature of early Chinese thought. It seems reasonable to believe that on some not-too-deep level, all these theories about human nature were responding to the political and social realities of the times.I have some concern about Chen's tendency, which is common among those working on Guodian material, to infer direct causal influence between these texts and later philosophical writings. As all philosophers know, inference is a tricky affair. If we find an earlier culture A, whose members wore trousers with two legs, and a later culture B, whose members also wore trousers with two legs, we might be led to infer that B picked up this practice from A. This would be rash. Both may have adopted the practice from a third culture C or each may have come upon the idea independently—after all, they... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Interpreting the MengziPhilip J. IvanhoeMencius: Contexts and Interpretations. Edited by Alan K. L. Chan. Honolulu: University of Hawai'i Press, 2002. Pp. vii + 328. Hardcover $51.00.Mencius: Contexts and Interpretations, edited by Alan K. L. Chan, is an important collection of essays from a scholarly conference held at the National University of Singapore in 1999. It begins with a concise yet incisive introduction to Mengzi, his work, and the various (...) contributions to the volume. The essays engage the Mengzi from a wide range of perspectives and employ a variety of different approaches. One of its many virtues is the inclusion of articles that explore the relationship of the text to recently excavated Guodian material. The primary audience of these essays is other scholars. However, several contributions could be understood and appreciated by nonspecialists as well.In the lead essay, Ning Chen criticizes a wide range of current accounts concerning the background of Mengzi's theory of human nature and argues that because of these mistaken impressions about Mengzi's intellectual context contemporary scholars fail to appreciate important features of Mengzi's own theory. Chen argues that in order to understand Mengzi's theory it is necessary to appreciate that he was responding to a heretofore unnoticed Mohist theory of human nature and to views that we find in certain Guodian texts. Both of these sources describe "inegalitarian" theories of human nature, and such theories served as a central focus of not only Mengzi's but Xunzi's theory of human nature as well.Some may find Chen's claims about the Mohist theory of human nature in need of further support. His evidence is a single passage from the later, dialectical chapters and the reading of this passage remains highly controversial. Given the importance of this issue for Mengzi and the significant debates Mengzi has with Mohists in various places in the Mengzi, it is quite strange that we see no direct reference to this theory in the text, nor do we find evidence of it in the core chapters of the Mozi. Chen argues that his interpretation is superior to that of Wu Yujing, who argues that the Mohists advocated the view that human nature was ethically neutral. However, Chen does not mention that others have produced quite impressive arguments in support of this same conclusion, for example David S. Nivison.Chen presents interesting and impressive textual work on Guodian texts and no one can deny that this material adds to our understanding of early Chinese philosophy. However, it is not yet clear how, if at all, these texts change our interpretation of Mengzi's theory itself. Even on the issue of what motivated thinkers like Mengzi [End Page 249] and Xunzi to argue for more "egalitarian" theories, it is not clear that Chen has identified anything strikingly new. While the Guodian texts do describe new and interesting theories concerning the character of human nature, these are not the first "inegalitarian" theories. Perhaps more important, one need not see thinkers like Mengzi as responding only or even primarily to explicit theories about human nature; there was ample motivation to argue for a fundamental moral equality among human beings in order to resist the inertia of hereditary rule. As Donald Munro argued in his classic work, The Concept of Man in Early China, this is a distinctive feature of early Chinese thought. It seems reasonable to believe that on some not-too-deep level, all these theories about human nature were responding to the political and social realities of the times.I have some concern about Chen's tendency, which is common among those working on Guodian material, to infer direct causal influence between these texts and later philosophical writings. As all philosophers know, inference is a tricky affair. If we find an earlier culture A, whose members wore trousers with two legs, and a later culture B, whose members also wore trousers with two legs, we might be led to infer that B picked up this practice from A. This would be rash. Both may have adopted the practice from a third culture C or each may have come upon the idea independently—after all, they... (shrink)

Two firm points in the chronology of Antiphon's speeches are VI περ το χορευτο in 419/81 and the Defence in 411/02. Speech V περ τσ 'Hρδου is now generally dated between these two; only the vaguest attempts have been made to date I κατ τσ μητρυασ; there is no general agreement on either the date or the authorship of the Tetralogies. The main purpose of this paper is to adduce linguistic as well as external evidence for the dating of V (...) in the neighbourhood of 414 and to show grounds for dating I between VI and V. Its secondary purpose is to apply some of the results gained in this inquiry to the fragments and the Tetralogies. (shrink)

The integrated information theory is a promising theory of consciousness. However, there are several problems with IIT's axioms and postulates. Moreover, IIT entails that some twodimensional grids of identical logic gates have more consciousness than humans. Many have found this prediction to be implausible, and as will be argued here, this prediction also exacerbates the so-called 'hard problem of consciousness'. Recently, it has been argued that if we treat the phenomenological aspects of consciousness as an illusion, we can avoid the (...) hard problem altogether by replacing it with the more tractable illusion problem: the problem of explaining how introspection systematically misrepresents experiences as having phenomenology. IIT is intended to be a theory of the phenomenological aspects of consciousness. However, it is possible to reformulate the axioms and postulates of IIT consistently with illusionism. Here it is argued that the resulting theory -- illusionist integrated information theory -- removes several problems for IIT including the hard problem and the logic gate problem, and also enables meaningful progress for illusionists on solving the illusion problem. (shrink)

ABSTRACT:Regulatory focus theory is proposed as offering an explanation for the influence of ethical leadership on organizational citizenship behaviors and employee commitments. The prevention focus mindset of an employee is argued to be the mechanism by which an ethical leader influences extra-role compliance behavior as well as normative commitment, whereas the promotion focus mindset of an employee is argued to be the mechanism by which an ethical leader influences extra-role voice behavior as well as affective commitment. Moreover, leader-member exchange is (...) proposed as a moderator of the relationship of ethical leadership to regulatory focus mindsets and employee behavior and commitments. Using the data collected in two waves from 250 working adults, we tested the proposed relationships with moderated mediation bootstrap procedures. The findings generally support the hypothesized relationships and point toward important implications for ethical leadership in work settings. (shrink)

This historical survey of Greek literature from 700 BC to 550 AD concentrates on the principal authors and quotes many passages from their work in translation, to allow the reader to form his own impression of its quality, including Homer, Plato, Aristophanes, and Euripides. Attention is drawn both to the elements in Greek literature and attitudes to life which are unfamiliar to us, and to the elements which appeal most powerfully to succeeding generations. Although it is recognized that this appeal (...) lies above all in the most creative and inventive period, an account is given of the eight hundred years which followed, which saw the impact of earlier inspirations. Poetry, tragedy, comedy, history, science, philosophy, and oratory are all examined through the available literature. This new edition has been revised to take account of recent scholarship, such as the influence of oriental traditions of Greek literature, and includes several new translations and a thoroughly updated bibliography. (shrink)

On the analogy of the colloquial register in some modern languages, where narrative and argument may be punctuated by oaths and exclamations in order to maintain a high affective level and compel the hearer's attention, it is reasonable to postulate that Attic conversation also was punctuated by oaths, that this ingredient in comic language was drawn from life, and that the comparative frequency of ║ M M Δ in comedy is sufficiently explained thereby. There are obvious affinities between some passages (...) of comedy, relaxed conversation in Plato and Xenophon, and the forceful, man-to-man tone which Demosthenes sometimes adopts to such good effect . Compare, for instance, Ar. V. 133 f. στιν δ' νομα ⋮ τ μν γέροντι ⋮ Φιλοκλέων / να μ Δία, τ δ' υε κτλ., where the oath is a response to imagined incredulity, and X. Smp. 4.27 ατν δ σέ, η, γ εδον να μ τν πόλλω, τε κτλ. . It is also important that the commonest oaths fit, in most of their forms, the end of an iambic trimeter: μ τν Δία, ν Δία,ν τούς θεούς, μ τος θεούς. Add that in Aristophanic dialogue over half the iambic trimeters end with major pause, and half the remainder with minor pause, and we can see why Δ / established itself early as a distinctive comic pattern. Out of 105 examples of M M Δ cited from comedy in Section II above, 59 have the oath at verse-end. In the case of πάνυ, which was almost exclusively Attic and — to judge from its great rarity in tragedy — felt by Athenian poets to be prosaic, we lack evidence on its functions in the colloquial register; it may or may not have served as affective punctuation. In prose, we have to reckon with the fact that π Mπ and Mπ π constituted a genuine stylistic choice as far back as the evidence will take us, since the two earliest instances in prose are [X.] Ath. 2.3 πάνυ δι χρείαν and ibid. 3.5 πολλ τι πάνυ. The oath, as treated by the comic poets on the basis of colloquial usage, is bound to have served as a model for πάνυ, exerting an influence which pulled πάνυ to the end of the verse, but there was also a powerful metrical constraint. As a dibrach ending in a vowel which could not be elided or enter into crasis, πάνυ was especially appropriate for verse-end. That in itself was enough both to establish Mπ π as the dominant pattern in comedy and to promote Mπ … π. Out of the total of 104 examples of Mπ π in comedy, 93 have πάνυ at verse-end, which makes Mπ π / one of the hallmarks of comic style. Mπ … π does not occur in prose in association with any other feature identified as colloquial, but it should be noted that Aiskhines and Demosthenes are much fonder of Mπ π than other prose authors. In some cases one can see that the order Mπ π avoids a succession of short syllables or hiatus or both , but there are other cases in which it has the opposite effect . The possibility of comic influence on oratorical language cannot be dismissed out of hand. It is also possible that someone will find positive determinants which will explain all the cases of Mπ π in prose. σόδρα, which, like πάνυ, is peculiarly Attic, is metrically more tractable than πάνυ, since it can be elided; even so, out of the 80 comic examples of Mσ σ no less than 58 have σόδρα at verse-end, and of those 58 there are 22 at major pause, 8 at presumed major pause and 9 at minor pause. The comic treatment of σόδρα is thus comparable with the treatment of πάνυ, and Timokles 222.4 τηρεν…σόδρα is in fact the closest analogy we have to Ar. Pl. 234 f. χθομαι…πάνυ. δέ and γάρ are a different matter, and in some significant respects different from each other. Postponement of δέ is especially prominent in Aeschylus and then abundant in fourth-century comedy. It is much less common in Euripides , rare in Sophocles and Aristophanes , and virtually limited in prose to the categories which I labelled –. There is as yet no evidence to associate postponement of δέ with colloquial language; on the contrary, it seems to have begun as a feature of poetic language and to have been taken up and exploited by fourth-century comedy. If, in addition to being Aeschylean, it was colloquial in the fourth century, what happened to it afterwards? Except for such an isolated and inexplicable case as Diod. xx85.1 — in a military narrative — it is not a feature of the Koine at literary, documentary or subliterate level. Postponement of γάρ was no doubt encouraged by postponement of δέ, but it is not itself notably poetic ). One can see how it could possibly have developed in the spoken language of the fourth century, extending the function of γάρ as an explanatory particle in a way which makes it comparable with the English ‘you see’ in ‘He didn't dare pick it up. He hurt his back last year, you see’. For an extension of this kind we may compare the current extension of the English genitive affix in ‘Then the girl whose place she was taking's mother turned up’ and ‘The man that Christopher liked's Introduction is much better’. Moreover, postponed γάρ appears in a segment of conversation constructed in indirect speech by Theophrastus in Char. 8.9 τ πργμα βοσθαι γάρ . Again we must ask: what happened to it afterwards? A couple of cases in Theophrastus' botanical works could be a reflex of the influence of comedy on literary language at Athens. The influence was plainly short-lived, since it did not affect the Koine. It is not hard to see why serious poetry in the fifth century and earlier should have experimented occasionally with the postponement of δέ and γάρ: treatment of M M q as a valid alternative to M q M is metrically very convenient. No poet, however, could afford to use common words in a bizarre, un-Greek way merely to save himself time and trouble in constructing a verse. Linguistic innovation is normally analogical, proceeding by extension from a starting-point already there, and the most obvious starting-point for postponement of δέ and γάρ is constituted by my class . This consideration provides comic postponement with a pedigree, but does not deny it individuality. The remarkable scale and frequency with which comedy exploited a phenomenon which tragedy used with restraint and prose hardly at all gives comic postponement the right to be regarded as a quite distinctive artificial feature of comedy. (shrink)

On the analogy of the colloquial register in some modern languages, where narrative and argument may be punctuated by oaths and exclamations (sometimes obscene or blasphemous) in order to maintain a high affective level and compel the hearer's attention, it is reasonable to postulate that Attic conversation also was punctuated by oaths, that this ingredient in comic language was drawn from life, and that the comparative frequency of ║ (|)M M(M) Δ in comedy is sufficiently explained thereby. There are obvious (...) affinities between some passages of comedy, relaxed conversation in Plato and Xenophon, and the forceful, man-to-man tone which Demosthenes sometimes adopts to such good effect (e.g. xxi 209). Compare, for instance, Ar.V.133 f.ἔστιν δ' ⋯νομα ⋮ τῷ μ⋯ν γέροντι ⋮ Φιλοκλέων / να⋯ μ⋯ Δία, τῷ δ' υἱεῖ κτλ., where the oath is a response to imagined incredulity, and X.Smp.4.27αὐτ⋯ν δ⋯ σέ, ἔɸη, ⋯γὼ εἶδον να⋯ μ⋯ τ⋯ν Ἀπόλλω, ὅτε κτλ. (‘Oh, yes, I did!’).It is also important that the commonest oaths fit, in most of their forms, the end of an iambic trimeter:(να⋯) μ⋯ τ⋯ν Δία, ν⋯ (τ⋯ν) Δία,ν⋯ τούς θεούς, μ⋯ τοὺς θεούς. Add that in Aristophanic dialogue (by contrast with Menander) over half the iambic trimeters end with major pause, and half the remainder with minor pause, and we can see why Δ / established itself early as a distinctive comic pattern. Out of 105 examples ofM M(M) Δ cited from comedy in Section II above, 59 have the oath at verse-end.In the case ofπάνυ, which was almost exclusively Attic and — to judge from its great rarity in tragedy — felt by Athenian poets to be prosaic, we lack evidence on its functions in the colloquial register; it may or may not have served as affective punctuation. In prose, we have to reckon with the fact thatπ MπandMππconstituted a genuine stylistic choice (cf. n. 32) as far back as the evidence will take us, since the two earliest instances in prose are [X.]Ath.2.3πάνυ δι⋯ χρείανand ibid. 3.5πολλ⋯ ἔτι πάνυ. The oath, as treated by the comic poets on the basis of colloquial usage, is bound to have served as a model forπάνυ, exerting an influence which pulledπάνυto the end of the verse, but there was also a powerful metrical constraint. As a dibrach ending in a vowel which could not be elided or enter into crasis,πάνυwas especially appropriate for verse-end. That in itself was enough both to establishMππas the dominant pattern in comedy and to promoteMπ…π. Out of the total of 104 examples ofMπ(…)πin comedy, 93 haveπάνυat verse-end, which makesMπ(…)π/ one of the hallmarks of comic style.Mπ…πdoes not occur in prose in association with any other feature identified as colloquial, but it should be noted that Aiskhines and Demosthenes are much fonder ofMππthan other prose authors. In some cases one can see that the orderMππavoids a succession of short syllables (e.g. D. xviii 130, liv 1) or hiatus (e.g. D. xxx 36) or both (e.g. D. xliii 10), but there are other cases in which it has the opposite effect (e.g. D. xxiv 140, xliii 53). The possibility of comic influence on oratorical language cannot be dismissed out of hand. It is also possible that someone will find positive determinants which will explain all the cases ofMππin prose.σɸόδρα, which, likeπάνυ, is peculiarly Attic, is metrically more tractable thanπάνυ, since it can be elided; even so, out of the 80 comic examples ofMσ(…) σ no less than 58 haveσɸόδραat verse-end, and of those 58 there are 22 at major pause, 8 at presumed major pause and 9 at minor pause. The comic treatment ofσɸόδραis thus comparable with the treatment ofπάνυ, and Timokles (CGFP) 222(b).4τηρεῖν…σɸόδραis in fact the closest analogy we have to Ar.Pl.234 f.ἄχθομαι…πάνυ.δέandγάρare a different matter, and in some significant respects different from each other. Postponement ofδέis especially prominent in Aeschylus (45 examples, including a few in which the text is suspect) and then abundant in fourth-century comedy. It is much less common in Euripides (18 examples), rare in Sophocles (6) and Aristophanes (6), and virtually limited in prose to the categories which I labelled (l)–(3). There is as yet no evidence to associate postponement ofδέwith colloquial language; on the contrary, it seems to have begun as a feature of poetic language and to have been taken up and exploited by fourth-century comedy. If, in addition to being Aeschylean, it was colloquial in the fourth century, what happened to it afterwards? Except for such an isolated and inexplicable case as Diod. xx85.1 (v.l.!) — in a military narrative — it is not a feature of the Koine at literary, documentary or subliterate level.Postponement ofγάρwas no doubt encouraged by postponement ofδέ, but it is not itself notably poetic (20 examples in tragedy, of which only three come in my class (5)). One can see how it could possibly have developed in the spoken language of the fourth century, extending the function ofγάρas an explanatory particle (rather on the lines ofγε) in a way which makes it comparable with the English ‘you see’ in (e.g.) ‘He didn't dare pick it up. He hurt his back last year, you see’. For an extension of this kind we may compare the current extension of the English genitive affix in (I heard both examples a year or two ago) ‘Then the girl whose place she was taking's mother turned up’ and ‘The man that Christopher liked's Introduction is much better’. Moreover, postponedγάρappears in a segment of conversation constructed in indirect speech by Theophrastus inChar.8.9τ⋯ πρ⋯γμα βο⋯σθαι γάρ(p C N γάρ). Again we must ask: what happened to it afterwards? A couple of cases in Theophrastus' botanical works (CPiii 11.3 andHPiv 6.1) could be a reflex of the influence of comedy on literary language at Athens. The influence was plainly short-lived, since it did not affect the Koine.It is not hard to see why serious poetry in the fifth century and earlier should have experimented occasionally with the postponement ofδέandγάρ: treatment ofM M qas a valid alternative toM q Mis metrically very convenient. No poet, however, could afford to use common words in a bizarre, un-Greek way merely to save himself time and trouble in constructing a verse. Linguistic innovation is normally analogical, proceeding by extension from a starting-point already there, and the most obvious starting-point for postponement ofδέandγάρis constituted by my class (3). This consideration provides comic postponement with a pedigree, but does not deny it individuality. The remarkable scale and frequency with which comedy exploited a phenomenon which tragedy used with restraint and prose hardly at all gives comic postponement the right to be regarded as a quite distinctive artificial feature of comedy. (shrink)