We propose protein localization dependent signal activation (PLDSA) as a model to describe pre‐existing protein partitioning between the cytosol, and membrane surface, as a means to modulate signal activation, specificity, and robustness. We apply PLDSA to explain possible molecular links between type II diabetes mellitus (T2DM) and Alzheimer's disease (AD) by describing Ca+2‐mediated interactions between the Src non‐receptor tyrosine kinase and p52Shc adaptor protein. We suggest that these interactions may serve as a contributing factor to disease development and progression. In (...) particular, we propose that signaling response is regulated, in part, by Ca+2‐mediated partitioning of lipid‐bound and soluble forms of Src and p52shc. Thus, protein‐protein interactions that drive signaling in response to extracellular ligand binding are also mediated by partitioning of signaling proteins between membrane‐bound and soluble populations. We propose that PLDSA effects may explain, in part, the evolutionary basis of promiscuous protein interaction domains and their importance in cellular function. (shrink)

This paper explores the psychological motivations behind collectivist behavior in Japan and the U.S. Using data from a large-scale questionnaire survey, we examine the causes of collectivist behavior (i.e., group conformity) at workplaces and at home. Our key findings are as follows: (i) in Japan, people conform to their groups, both at work and at home, because they consider that cooperation with others will result in greater achievement; (ii) in both Japan and the U.S., people conform to their groups, both (...) at work and at home, because behaving similarly to others makes them feel comfortable; and (iii) in both Japan and the U.S., people conform to their family’s opinion at home because they value cooperation with family members. Our findings suggest that institutional differences between Japan and the U.S. give rise to the differences in psychological motivations for collectivist behavior. (shrink)

From an institutional perspective we contribute to corporate governance of firms by (1) proposing a procedurally fair mechanism that is ethically desirable, and (2) experimentally testing whether procedural fairness crowds-in ethical behavior of managers (on behalf of shareholders) and workers. The experiment sees one ‘manager’ and three ‘workers’ (possibly representing three sections of the firm) co-determining an efficiency-enhancing investment which could harm some workers. Firstly, the manager claims a share of the investment surplus, then workers ‘bid’ for the investment to (...) express their willingness to satisfy the manager’s claim in case the investment is implemented. If the sum of workers’ bids is less than the manager’s claim, the investment is not implementable, which means its surplus will be lost. Workers’ behavior is ‘ethical’ when they veto unfair managerial claims, because the workers have to sacrifice own earnings. Hence, a manager’s fair claim is the ethical response to the threat of workers’ veto. If the manager claims fairly, workers’ ethical behavior is to ‘truthfully’ bid their investment evaluations; by all doing so, they equally share whatever surplus the manager has left for them. The experimental results show ethical behavior of managers in the form of fair claims. Despite these fair claims, workers behave less ethically by strategically underbidding. So the procedurally fair mechanism only partially crowds-in ethical behavior. This study should interest theorists of stakeholder management, especially those engaged in designing the rules of corporate governance. (shrink)

We clarify the significance of quasiprobability in quantum mechanics that is relevant in describing physical quantities associated with a transition process. Our basic quantity is Aharonov’s weak value, from which the QP can be defined up to a certain ambiguity parameterized by a complex number. Unlike the conventional probability, the QP allows us to treat two noncommuting observables consistently, and this is utilized to embed the QP in Bohmian mechanics such that its equivalence to quantum mechanics becomes more transparent. We (...) also show that, with the help of the QP, Bohmian mechanics can be recognized as an ontological model with a certain type of contextuality. (shrink)

In this paper, we propose the c AS, a new ACO algorithm, and evaluate the performance using TSP instances available at TSPLIB. The results show that c AS works well on the test instances and has performance that may be one of the most promising ACO algorithms. We also evaluate c AS when it is combined with LK local search heuristic using larger sized TSP instances. The results also show promising performance. c AS introduced two important schemes. One is to (...) use the colony model divided into units, which has a stronger exploitation feature while maintaining a certain degree of diversity among units. The other is to use a scheme, we call cunning, when constructing new solutions, which can prevent premature stagnation by reducing strong positive feedback to the trail density. (shrink)

This study investigates the individual outcomes of irrational thinking, including belief in the paranormal and non-scientific thinking. These modes of thinking are identified through factor analysis of eleven questions asked in a large-scale survey conducted in Japan in 2008. Income and happiness are used as measures of individual performance. We propose two hypotheses. Previous studies in finance lead us to consider Hypothesis 1 that both higher belief in the paranormal and non-scientific thinking are associated with lower income. Literature on the (...) association between religion, the paranormal, and happiness suggest Hypothesis 2 that higher belief in the paranormal is associated with greater happiness, while higher non-scientific thinking is associated with greater unhappiness. To examine these hypotheses, we regress income and happiness on belief in the paranormal and non-scientific thinking with appropriate control variables. We employ the Mincer-type wage function as the income equation. Income, sex, and age are controlled in the happiness equation. Analysis supports both hypotheses, which highlights the complex features of irrationality. Although irrationality results in diminishing financial profitability, the component of belief in the paranormal improves the psychological state. (shrink)

In this paper, we perform theoretical analysis and experiments on the Simplex Crossover (SPX), which we have proposed. Real-coded GAs are expected to be a powerful function optimization technique for real-world applications where it is often hard to formulate the objective function. However, we believe there are two problems which will make such applications difficult; 1) performance of real-coded GAs depends on the coordinate system used to express the objective function, and 2) it costs much labor to adjust parameters so (...) that the GAs always find an optimum point efficiently. The result of our theoretical analysis and experiments shows that a performance of SPX is independent of linear coordinate transformation and that SPX always optimizes various test function efficiently when theoretical value for expansion rate, which is a parameter of SPX, is applied. We also show that BLX-α is equivalent to degenerate form of SPX. Experiments show that we have something misunderstood effect of epistasis on performance degradation of real-coded GAs. (shrink)

In print for the first time in over ten years, Act and Crime provides a unified account of the theory of action presupposed by both Anglo-American criminal law and the morality that underlies it. The book defends the view that human actions are always volitionally caused bodily movements and nothing else. The theory is used to illuminate three major problems in the drafting and the interpretation of criminal codes: 1) what the voluntary act requirement both does and should require; 2) (...) what complex descriptions of actions prohibited by criminal codes both do and should require ; and 3) when two actions are 'the same' for purposes of assessing whether multiple prosecutions and multiple punishments are warranted. The book both contributes to the development of a coherent theory of action in philosophy, and it provides both legislators and judges a grounding in three of the most basic elements of criminal liability. (shrink)

In this short, dense essay, Jean Cavaillès evaluates philosophical efforts to determine the origin - logical or ontological - of scientific thought, arguing that, rather than seeking to found science in original intentional acts, a priori meanings, or foundational logical relations, any adequate theory must involve a history of the concept. Cavaillès insists on a historical epistemology that is conceptual rather than phenomenological, and a logic that is dialectical rather than transcendental. His famous call (cited by Foucault) to abandon "a (...) philosophy of consciousness" for "a philosophy of the concept" was crucial in displacing the focus of philosophical enquiry from aprioristic foundations toward structural historical shifts in the conceptual fabric. This new translation of Cavaillès's final work, written in 1942 during his imprisonment for Resistance activities, presents an opportunity to reencounter an original and lucid thinker. Cavaillès's subtle adjudication between positivistic claims that science has no need of philosophy, and philosophers' obstinate disregard for actual scientific events, speaks to a dilemma that remains pertinent for us today. His affirmation of the authority of scientific thinking combined with his commitment to conceptual creation yields a radical defense of the freedom of thought and the possibility of the new. (shrink)

Tri filosofskikh "opravdanii︠a︡" (teodit︠s︡ei︠a︡, antropodit︠s︡ei︠a︡, kosmodit︠s︡ei︠a︡ Serebri︠a︡nogo veka) -- Russkai︠a︡ sofiologii︠a︡ i kabbala -- S. Bulgakov : nauka sofiologii︠a︡ (ili konet︠s︡ religii) -- Tretiĭ Zavet o. Sergii︠a︡ Bulgakova -- Tretʹezavetnai︠a︡ misterii︠a︡ ("malai︠a︡" trilogii︠a︡ Bulgakova).

v. 1. pt. 1. Babaji's glimpses of the Tamil 18 Siddhas. pt. 2. [non-Roman data].

In Alfonso de Cartagena's 'Memoriale virtutum' (1422) María Morrás and Jeremy Lawrance offer a new edition from the manuscripts of a compilation of Aristotle's Nicomachean Ethics addressed by the major Castilian intellectual of the day, bishop Alfonso de Cartagena, to the heir to the throne of Portugal, crown prince Duarte. The work was a speculum principis, an education for the future king in the virtues suitable to a statesman; Cartagena's choice of Aristotle was thus a significant index of the advent (...) of new Renaissance ideas. This edition shows how the "memorial" throws light on the ideological transformation of society those ideas would bring, setting new ethical guidelines for the ruling class at the crossroads between medieval feudalism and Renaissance absolutism. (shrink)

Contributors to this volume consider the implications of 'the Age of Breath': a spiritual shift in human awareness to the needs of the other figured through breathing.

Verse treatises on Advaita Jaina, and Nyaya philosophy.

Biography of Jayatīrtha, fl. 1365-1388, Indian philosopher.