The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

Jean Vanier's life and teaching bore good fruit, but what is good was wrapped up from the very beginning with manipulative and abusive behaviors justified in theological language. For those of us who do not have access to the voices of the victims themselves, it is important to at least analyze the long-public writings of Fr. Thomas Philippe and Jean Vanier. Until now these were all that was available to those interested in the theology of L’Arche, and in them their (...) erotico-mystical theology was hidden in plain sight. A close reading of these texts points to a deformed eschatology as the fatal theological doctrine Vanier inherited from Philippe. More precisely, eschatological concepts were deployed in order to declare traditionally prohibited sexual activities as licit, in being concieved as taking place beyond the mundane domain of everyday morality. A nuptial union taking place outside the ethics of normal Christian life brought affectionate union with God down into the contingency of everyday ethics in a manner that circumvented well-known church teachings about sexual ethics. (shrink)

This paper elucidates Bonhoeffer's understanding of Christian ethics as a `way'. The concept is prominent in his unfinished exegesis of Psalm 119 and shapes his Ethics, written during the same time period. This reading of Bonhoeffer's ethics yields the claim that he gave a much more central role to biblical exegesis in his ethical framework than is typically granted. It concludes that much of the criticism of his concept of the mandates reveals not the weakness of the concept, but a (...) misunderstanding of both his conception of Christian ethics as a way, and the importance of theological exegesis in his thought. (shrink)

By examining the range of factors pressing on medical professionals faced with a decision in a case of late-term abortion, it becomes apparent that the theological resources ruled out of bounds by the standard account can be considered an essential part of a truly liberating and properly supple moral account of medical decision-making. Close attention to the social, political and legal context of contemporary medicine reveals that the standard account of medical ethics, Principles of Biomedical Ethics by Beauchamp and Childress, (...) despite its universalist aspirations, disempowers rather than empowers moral decision-making by medical professionals. (shrink)

This paper outlines Hans Ulrich's reworking of the Lutheran doctrine of the estates. He conceives the estates as descriptions of the new patterns of social life that God has promised to found and secure. This emphasis on the divine activity of generating social order is an expression of Ulrich's agreement with common and familiar criticisms of the doctrine, and why he nevertheless believes it indispensable for an evangelical ethic. A construal of the traditional doctrine of the estates that is unique (...) even in his native Lutheran context, it aims not at conservatism, but at a more thoroughly theological and therefore critical relationship to social order than rival theories much more inclined to revisionist rhetorical stances. In a contemporary context in which moral certainties and categories can be disputed at the most fundamental levels, Ulrich's theology seeks a form of theological reasoning that genuinely seeks the illumination of Christian beliefs about reality by taking other moral languages seriously. (shrink)

Alzheimer's disease is characterized by amyloid-beta peptide -loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 , which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and localization (...) of SP1, APP, and Abeta in various brain regions of rodent and primate models using immunohistochemistry. We observed that overall distribution and cellular localization of SP1, APP, and Abeta are similar and neuronal in origin. Their distribution is abundant in various layers of neocortex, but restricted to the Purkinje cell layer of the cerebellum, and the pyramidal cell layer of hippocampus. These findings suggest that overproduction of Abeta in vivo may be associated with transcriptional pathways involving SP1 and the APP gene. (shrink)

Introduction: Christian faith and technological artifacts -- Pt. I. The attempt to claim Christ's dominion. Martin Heidegger on technology as a form of life -- George Grant and the technological ideal -- Michel Foucault and the habits of technology -- Pt. II. Seeking Christ's concrete claim. Advent and the renewal of the senses -- Technology for good and evil -- Political reconciliation in the community of worship -- Worship, Sabbath, and work -- Being reconciled with creation's material form -- Conclusion: (...) An ethos of dwelling in the house of the Lord. (shrink)

This paper explores the role of divine speaking in Christian ethics, critically engaging with the tendency in modern evangelicalism to seek to derive moral principles from Scripture or a biblically-derived ontology, often via deployment of map-making metaphors. The paper sets out the rather different centrality of the divine claim found in biblical accounts of good or righteous human action. Drawing on the criticisms of the anthropologist Tim Ingold of what he calls the “map-making fallacy,” the paper concludes by suggesting the (...) methodological importance of understanding the orientation of the Christian life to be a fundamentally grounded in interpersonal responsivity. (shrink)

In 1 Cor. 9:25 Paul exhorts the Corinthian believers to strive like athletes for an eternal prize. This paper elucidates the communal horizon of the self-disciplining he enjoins, which overturns popular modern conceptions of individual fitness and performance training. Paul likewise defines the rewards of spiritual labour as aspects of participation in the communion of saints gathered by the gospel, disallowing a wholly post-temporal construal of the eternal reward which motivates Christian discipline. The paper concludes by raising questions about the (...) theological status of modern sport, of theologies of sport, and of competition as a form of social organisation. (shrink)

The proposal by Adam Smith that the market is a primal human reality has arguably been the most influential of the myths offered as a substitute for the authoritative story of Eden by the Enlightenment’s founding fathers. This essay examines how rival primal stories shape agents’ moral stances by directing attention, framing conceptual priorities and in situating stated and unstated analytical presuppositions in contemporary economic discourses. Contemporary scholars have recently emphasised that the root metaphor of Smith’s economic theory is original (...) barter. Tracing this scholarship, I will show how this picture of the human economic agent grounds the central tenets of the emerging global economic order. This vision will, however, then be shown to contrast with both the biblical vision of human economic activity, medieval and reformation theological appropriations of this vision, and the political and economic institutions that pre-modern Christendom developed to express their belief in a human responsibility to serve the divine sustenance of the human race. I will conclude by suggesting why the transition from Christendom to modern global capitalism demands a deeper than usual theological analysis of phenomena we usually refer to under the heading of globalisation, calling for reformulations of basic Christian and non-Christian presumptions about economic practice and ethics. (shrink)

Kenneth Burke and Contemporary European Thought reflects the present transitory nature of rhetoric and society. Its purpose is to relate the rhetorical theory and critical approaches of American critic Kenneth Burke to four major European philosophers - Jurgen Habermas, Ernesto Grassi, Michel Foucault, and Jacques Derrida - as they discuss the nature of language and its central role in society. Supporting transitory forces in society, all these thinkers reject traditional, scientific, objective, reductionist thought and point to language or symbols as (...) the basis for understanding experience and knowledge. Burke, Habermas, and Grassi approach language by establishing global theories. In contrast to these global approaches, Foucault and Derrida attack language and the human situation microscopically. Michel Foucault examines "discursive practices" to discover relationships among the concepts of rhetoric, knowledge, and power. Derrida focuses on the methods of difference and deconstruction because he believes human beings are trapped by their own language, which inherently carries multiple meanings that need to be unpacked or deconstructed. (shrink)

In his Confessions Augustine recasts the Greco-Roman dialogue as a conversation with God. This repositioning of the premier pedagogical form of the ancient world Augustine takes as an implication of the Christian confession of God as a speaking God. Introducing Jewish forms of prayer into the Greco-Roman dialogue form transforms it in a manner that has implications for the teaching of Christian ethics today, in offering a theologically elaborated model of the formative and investigative power of conversation. Conversational learning is (...) a practice in which finite creatures lovingly explore a creation that cannot be comprehended completely. Christians understand this formative and explorative conversation as a conversation with God, mediated by Scripture, which prepares its participants to model trust-building conversation in public. (shrink)

Introduction: the problem of estrangement from Scripture in Christian ethics -- Learning about reading the Bible for ethics -- Reading self-consciously : the hermeneutic solution -- Reading together : the communitarian solution -- Focusing reading : the biblical ethics solution -- Reading doctrinally : the biblical theology solution -- Reading as meditation : the exegetical theology solution -- Listening to the saints encountering the ethos of Scripture -- Augustine's ethos of salvific confession -- Luther's ethos of consoling doxology -- Singing (...) the ethos of God -- Ethical exegesis : what have we encountered -- Exploring the place of Christian ethics in Scripture. (shrink)

Insights into the problem of our relation to language Kenneth Burke and Contemporary European Thought: A Rhetoric in Transition reflects the present transitional nature of rhetoric and society. Its purpose is to relate the rhetorical theory of Burke to the theories of four major European philosophers--Jürgen Habermas, Ernesto Grassi, Foucault, and Jacques Derrida--as they discuss the nature of language and its central role in society. This book describes a rhetorical world in transition but not a world in chaos. It points (...) to the centrality of symbolism in theories of language and rhetoric and illustrates Burke's influence as a pivotal things and theorist in the communication arts and sciences, suggesting that the observations regarding shifting paradigms and perspectives made by other scholars are indeed emergent in the realm of rhetoric. It also regards the powerful impact of language and symbolic action in both the critique and construction of human knowledge and augurs a central role for rhetoric in the intellectual and social transformations of this and the next century. (shrink)

In this wide-ranging and engaging collection of interviews, Brian Brock discusses how Christian faith makes a difference for life in the modern world. Beginning with a discussion of teaching Christian ethics in the contemporary academy, Brock takes up environmental questions, political and medical ethics, the modern city and Christian responsibility to it, energy use, the information age, agriculture, political consensus and coercion, and many other issues. The reader is thus offered a broad and incisive discussion of many contemporary topics in (...) a brief, illuminating, but never superficial manner. The book's unusual conversational style allows strikingly clear, creative, and concrete theological connections to emerge in the spaces between moral questions rarely thought of as linked. As the titles suggests, the running theme of the interviews is being bound to Christ and placed into the contemporary world. Brock's theological readings of contemporary cultural trends are vigorous, unapologetic, and insightful, and they offer delightful surprises as well as fertile new ways through the sterile impasses of many issues currently being debated in the public square. This book provides an excellent starting point for those interested in fresh theological insights into contemporary ethical questions and an accessible introduction to Brock's previous works. (shrink)

What is the significance of the Protestant Reformation for Christian ethical thinking and action? Can core Protestant commitments and claims still provide for compelling and viable accounts of Christian living. This collection of essays by leading international scholars explores the relevance of the Protestant Reformation and its legacy for contemporary Christian ethics.