Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

We welcome Ballantyne & Schaefer’s discussion of the issues concerning consent and use of health data for research. In response to their acknowledgement of the need for public debate and discussion, we provide evidence from our own public consultation on this topic.

ABSTRACT Present-day fixations on “embodied minds,” and “enactive” assessments of life fail to recognize alive, moving bodies, precisely as James Joyce implicitly shows in his experience-anchored descriptions of the ineluctable modality of the visual and of the audible. Joyce's experience-anchored descriptions accord with Edmund Husserl's renditions of “the kinestheses” and their integral relationship to perception and to the development of agency. They furthermore accord with John Dewey's writing on aesthetics that describe the immediacy of motion into sense and sense (...) into motion in both nonhuman animal life and aesthetic experience. William James's connection of the stream of thinking with the stream of breathing is in further accord. Such accords show that animate forms of life are essentially mindful bodies sensuously and affectively attuned to their surrounding world. Cave art, both its creation and appreciation, is further testimony to mindful bodies as is internationally known musician Roger Sessions eloquent descriptions documenting the integrality of movement to all the arts. All such accords testify to the central and essential presence of the sense modality of movement—kinesthesia—and its bodily engaged dynamics in animate life and in art. (shrink)

Seventeen obituaries of recently deceased Fellows of the British Academy: Shackleton Bailey; James Barr; William Beasley; Lord Blake; Julian Budden; Lord Bullock; Robert Carson, Laurence Cohen; Charles Feinstein; Henry Gifford; Peter Holt; Emrys Jones; Robert Megarry; Edward Oates; Maurice Wiles; Brian Woledge; Austin Woolrych.

Authority in Morals: An Essay in Christian Ethics. By Gerard J. Hughes On Human Nature. By Edward O. Wilson Democracy and Ethical Life. By Claes G. Ryn The Foundations of Modern Political Thought. By Quentin Skinner. 2 vols. Phenomenology and the Social World: the Philosophy of Merleau‐Ponty and its Relation to the Social Conscience. By Laurie Spurting Philosophical Foundations of the Three Sociologies. By Ted Benton Christianity and the World Order. By Edward Norman. Oxford, Oxford University Press, 1979, £3.50. The (...) Stoics. Edited by John M. Rist Descartes. By Margaret D. Wilson Physicalism. By K.V. Wilkes Kierkegaard as Educator. By R.J. Manheimer Two Ages: The Age of Revolution and the Present Age. By Søren Kierkegaard, translated and edited by Howard and Edna Hong Parables of Kierkegaard. Edited by Thomas C. Oden Thomas Carlyle: ‘Cahinist without the Theology’. By Eloise M. Behnken The Praise of 'Sons of Bitches’. By James V. Schall The Inner Eye of Love. By William Johnston The River Within. By Christopher Bryant The Religious Imagination and the Sense of God. By John Bowker Old Testament Theology: A Fresh Approach. By Ronald E. Clements What is a Gospel? By Charles H. Talbert Urchristliche Prophetic. By Gerhard Dautzenberg Amphttochii Icontensis Opera. Edited by Cornells Datema Man and Nature in the Renaissance. By Allen G. Debus The Church in Late Victorian Scotland 1874–1900. By Andrew L. Drummond and James Bullock. Ppix, 342, Edinburgh, The St Andrew Press, 1978, £10.50. From Office to Profession: The New England Ministry 1750–1860. By Donald M. Scott Bemard‐Lazare: Anti‐Semitism and the Problem of Jewish Identity in Late Nineteenth Century France. By Nelly Wilson. (shrink)

From the $700 billion bailout of the banking industry to president Barack Obama’s $787 billion stimulus package to the highly controversial passage of federal health-care reform, conservatives and concerned citizens alike have grown increasingly fearful of big government. Enter Nobel Prize–winning economist and political theorist F. A. Hayek, whose passionate warning against empowering states with greater economic control, The Road to Serfdom, became an overnight sensation last summer when it was endorsed by Glenn Beck. The book has since sold over (...) 150,000 copies. The latest entry in the University of Chicago Press’s series of newly edited editions of Hayek’s works, The Constitution of Liberty is, like Serfdom, just as relevant to our present moment. The book is considered Hayek’s classic statement on the ideals of freedom and liberty, ideals that he believes have guided—and must continue to guide—the growth of Western civilization. Here Hayek defends the principles of a free society, casting a skeptical eye on the growth of the welfare state and examining the challenges to freedom posed by an ever expanding government—as well as its corrosive effect on the creation, preservation, and utilization of knowledge. In opposition to those who call for the state to play a greater role in society, Hayek puts forward a nuanced argument for prudence. Guided by this quality, he elegantly demonstrates that a free market system in a democratic polity—under the rule of law and with strong constitutional protections of individual rights—represents the best chance for the continuing existence of liberty. Striking a balance between skepticism and hope, Hayek’s profound insights are timelier and more welcome than ever before. This definitive edition of The Constitution of Liberty will give a new generation the opportunity to learn from his enduring wisdom. (shrink)

This first volume contains discussions of the brain, methods for analyzing behavior, thought, consciousness, attention, association, time, and memory.

For this 1897 publication, the American philosopher William James brought together ten essays, some of which were originally talks given to Ivy League societies. Accessible to a broader audience, these non-technical essays illustrate the author's pragmatic approach to belief and morality, arguing for faith and action in spite of uncertainty. James thought his audiences suffered 'paralysis of their native capacity for faith' while awaiting scientific grounds for belief. His response consisted in an attitude of 'radical empiricism', which (...) deals practically rather than ideologically with real-world phenomena. When facing a 'momentous' decision about belief, he says, we both can and must choose the best hypothesis. The first four essays apply this principle to religious faith, and the rest explore the pragmatic approach to such topics as determinism, ethics and individual achievement. James developed his ideas further in The Varieties of Religious Experience and Pragmatism, both of which are reissued in this series. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

One of the great American pragmatic philosophers alongside Peirce and Dewey, William James (1842–1910) delivered these eight lectures in Boston and New York in the winter of 1906–7. Though he credits Peirce with coining the term 'pragmatism', James highlights in his subtitle that this 'new name' describes a philosophical temperament as old as Socrates. The pragmatic approach, he says, takes a middle way between rationalism's airy principles and empiricism's hard facts. James' pragmatism is both a method (...) of interpreting ideas by their practical consequences and an epistemology which identifies truths according to their useful outcomes. Furnished with many examples, the lectures illustrate pragmatism's response to classic problems such as the question of free will versus determinism. Published in 1907, this work further develops James's approach to religion and morality, introduced in The Will to Believe (1897) and The Varieties of Religious Experience (1902), both reissued in this series. (shrink)

The Gifford Lectures were established in 1885 at the universities of St Andrews, Glasgow, Aberdeen and Edinburgh to promote the discussion of 'Natural Theology in the widest sense of the term - in other words, the knowledge of God', and some of the world's most influential thinkers have delivered them. The 1901–2 lectures given in Edinburgh by American philosopher William James are considered by many to be the greatest in the series. The lectures were published in book form (...) in 1902 and have been reprinted many times. James, who was educated in the United States and Europe, and spent much of his career teaching philosophy at Harvard, was very influential in the development of modern psychology, and in these twenty lectures he explores the personal experience of religion. Some of the topics include religion and neurology, 'the sick soul', saintliness, and mysticism. (shrink)

In his introduction to this collection, John representative. McDermott presents James's thinking in all its manifestations, stressing the importance of radical empiricism and placing into perspective the doctrines of pragmatism and the will to believe. The critical periods of James's life are highlighted to illuminate the development of his philosophical and psychological thought. The anthology features representive selections from The Principles of Psychology, The Will to Believe , and The Variety of Religious Experience in addition to the complete (...) Essays in Radical Empiricism and A Pluralistic Universe . The original 1907 edition of Pragmatism is included, as well as classic selections from all of James's other major works. Of particular significance for James scholarship is the supplemented version of Ralph Barton Perry's Annotated Bibliography of the Writings of William James , with additions bringing it up to 1976. (shrink)

v. 1. William and Henry, 1861-1884 -- v. 2. William and Henry, 1885-1896 -- v. 3. William and Henry, 1897-1910 -- v. 4. 1856-1877 -- v. 5. 1878-1884 -- v. 6. 1885-1889 -- v. 7. 1890-1894 -- v. 8. 1895-June 1899 -- v. 9. July 1899-1901 -- v. 10. 1902-March 1905 -- v. 11. April 1905-March 1908 -- v. 12. April 1908-August 1910.

A perfectly matched layer (PML) absorbing material composed of a uniaxial anisotropic material is presented for the truncation of finite-difference time-domain (FDTD) lattices. It is shown that the uniaxial PML material formulation is mathematically equivalent to the perfectly matched layer method published by Berenger (see J. Computat. Phys., Oct. 1994). However, unlike Berenger's technique, the uniaxial PML absorbing medium presented in this paper is based on a Maxwellian formulation. Numerical examples demonstrate that the FDTD implementation of the uniaxial PML medium (...) is stable, equal in effectiveness as compared to Berenger's PML medium, while being more computationally efficient. (shrink)

Noted psychologist and philosopher develops his own brand of pragmatism, based on theories of C. S. Peirce. Emphasis on "radical empiricism," versus the transcendental and rationalist tradition. One of the most important books in American philosophy. Note.

The first systematic study of the aesthetic evaluations that scientists pass on their theories.

Two books bound together, from the religious period of one of the most renowned and representative thinkers. Written for laymen, thus easy to understand, it is penetrating and brilliant as well. Illuminations of age-old religious questions from a pragmatic perspective, written in a luminous style.

One of the most influential men of his time, philosopher, psychologist, educator, and author William James (1842-1910) helped lead the transition from a predominantly European-centered nineteenth-century philosophy to a new "pragmatic" American philosophy. Helping to pave the way was his seminal book Pragmatism (1907), in which he included a chapter on "Truth," an essay which provoked severe criticism. In response, he wrote the present work, an attempt to bring together all he had ever written on the theory of (...) knowledge, including an article on the function of cognition, later polemic and expository contributions, and some replies to previous criticism. The result was a full and definitive expression of the pragmatist "epistemology" from James' point of view. In the book, he urges the reader to "turn away from abstractions, verbal solutions, fixed principles, and pretended absolutes and look for concreteness and facts, action and power," arguing that "the ultimate test for us of what a truth means is the conduct it dictates or inspires." For students, scholars--anyone interested in William James or the history of American philosophical thought--this book offers an in-depth exposition of the influential ideas of one of the greatest American thinkers. Unabridged republication of the edition originally published by Longmans, Green and Co., New York and London, 1909. (shrink)

This new critical edition is an examination of William James's Essays in Radical Empiricism in light of the scientific naturalism prominent in James's Principles of Psychology (1890) and the subsequent development of Darwinian, functional psychology and functionalism in psychology, the philosophy psychology and the philosophy of mind.

Please visit www.ArcManor.com for works by this and other authors.

By an “organism” I mean a living thing, in the most ordinary sense. There is an “organic theory of nature” in which the term “organism” is extended so as to include atoms, molecules, crystals, colloidal micelles, etc.; such constellations of parts have been called “inorganic organisms” by Driesch. I shall regard them as the “results of organization.” As we know them they are “models” , and they exist in the minds of physicists just as differential equations are in the minds (...) of mathematicians. They express arrangements just as a trade union is an arrangement, and just as artifacts, such as the nest of a chaffinch or the sleeping-bag of an Arctic explorer, are expressions of arrangements. (shrink)

“William James is a towering figure in the history of American thought--without doubt the foremost psychologist this country has produced. His depiction of mental life is faithful, vital, and subtle. In verve, he has no equal.... “There is a sharp contrast between the expanding horizon of James and the constricting horizon of much contemporary psychology. The one opens doors to discovery, the other closes them. Much psychology today is written in terms of reaction, little in terms of (...) becoming. James would say that a balance is needed, but that only by assuming that man has the capacity for growth are we likely to discover the scope of this same capacity.” —from the introduction by Gordon W. Allport. (shrink)

Several of William James' finest essays are brought together in this collection, including his spiritual masterwork The Will to Believe, and his famous lecture concerning immortality. The Will to Believe was first delivered as a lengthy lecture by William James in 1896. Following a strong reception, it was later published as a distinct book in its own right. Setting out to defend the right of individuals to be religious irrespective of pure logic and reason, the lecture (...) highlights many of the proven advantages conferred by the belief in a guiding divine force. The benefits of belief to the believer are thus noted. James deftly cites many real life examples to prove his points - noting that many tasks or duties require confidence, he notes how individuals can perform and surmount difficulties if they believe in the divine. For such persons to abandon faith would therefore be irrational, as their religious beliefs have helped them in life. This argument is closely aligned with James' personal philosophical alignment with pragmatism. The Will to Believe also contains arguments in favor of persons having their own free will. James contested simply that as he believed in his own free will, he had it. As well as this, we hear several philosophical arguments in which James discusses the merits of empiricism versus absolutism. Other essays in this compendium include 'Is Life Worth Living?' and 'The Dilemma of Determinism'. In these and other writings, James demonstrates a superb command of philosophical principles and theoretical daring, at various times explaining and refuting established discussions on the subjects. The final essay in this edition, Human Immortality, sees James object to the notion that humans cannot be immortal if their bodies and minds are separated due to death. He objects to the assertion that human thought is concluded if the brain ceases to function, noting that human consciousness exists with the world and may philosophically have a life of its own. Notable for both his psychological and philosophical ideas, William James would author numerous lectures and books surrounding both subjects. The importance of spiritualism to the human being, the permanence of the spirit, and its effects on the thought processes, is but one area in which James distinguished himself. (shrink)

Liberty-restricting measures have been implemented for centuries to limit the spread of infectious diseases. This article considers if and when it may be ethically acceptable to impose selective liberty-restricting measures in order to reduce the negative impacts of a pandemic by preventing particularly vulnerable groups of the community from contracting the disease. We argue that the commonly accepted explanation—that liberty restrictions may be justified to prevent harm to others when this is the least restrictive option—fails to adequately accommodate the complexity (...) of the issue or the difficult choices that must be made, as illustrated by the COVID-19 pandemic. We introduce a dualist consequentialist approach, weighing utility at both a population and individual level, which may provide a better framework for considering the justification for liberty restrictions. While liberty-restricting measures may be justified on the basis of significant benefits to the population and small costs for overall utility to individuals, the question of whether it is acceptable to discriminate should be considered separately. This is because the consequentialist approach does not adequately account for the value of equality. This value may be protected through the application of an additional proportionality test. An algorithm for making decisions is proposed. Ultimately whether selective liberty-restricting measures are imposed will depend on a range of factors, including how widespread infection is in the community, the level of risk and harm a society is willing to accept, and the efficacy and cost of other mitigation options. (shrink)

The original 1907 text is accompanied with a series of critical essays from scholars including Moore and Russell. In the introduction Olin evaluates the strength of the criticisms made against James.

The sentiment of rationality.--The dilemma of determinism.--The moral philosopher and the moral life.--The will to believe.--Conclusions on varieties of religious experience.--What pragmatism means.--Pragmatism's conception of truth.

Presents the American philosopher and experimental psychologist's study of such spiritual phenomena as conversion, repentance, mysticism, saintliness, the hope for reward, and the fear of punishment.